Scores & Fixtures 2022 USL Championship
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-03-12 | 18:00 | Loudoun Utd | 1–0 | Indy Eleven | 1,031 | Segra Field | John Matto | Match Report | |
| Sun | 2022-03-13 | 16:00 | B'ham Legion | 1–1 | TB Rowdies | 9,277 | Protective Stadium | Matthew Thompson | Match Report | |
| Sun | 2022-03-13 | 17:00 | New Mexico Utd | 2–0 | LV Lights FC | 11,247 | Isotopes Park | Gerald Flores | Match Report | |
| Sat | 2022-03-12 | 18:00 | Memphis | 0–3 | Pittsburgh | 2,431 | AutoZone Park | Kevin Broadley | Match Report | |
| Sat | 2022-03-12 | 18:00 | CS Switchbacks | 2–1 | Orange County | 5,036 | Weidner Field | Malik Badawi | Match Report | |
| Sat | 2022-03-12 | 19:00 | Charleston | 1–0 | FC Tulsa | 2,523 | Patriots Point Soccer Complex | Joshua Encarnacion | Match Report | |
| Sat | 2022-03-12 | 19:00 | Loyal | 2–1 | Galaxy II | 5,014 | Torero Stadium | Elijio Arreguin | Match Report | |
| Sat | 2022-03-12 | 19:00 | Miami FC | 2–0 | NY Red Bulls II | 1,244 | Riccardo Silva Stadium | Gabriele Giusti | Match Report | |
| Sat | 2022-03-12 | 19:00 | Sac Republic | 3–1 | El Paso | 11,569 | Heart Health Park | Elton Garcia | Match Report | |
| Sat | 2022-03-12 | 19:30 | Phx Rising | 4–2 | Monterey Bay | 8,409 | Wild Horse Pass Stadium | Calin Radosav | Match Report | |
| Sat | 2022-03-12 | 19:30 | San Antonio | 1–0 | Detroit City | 6,033 | Toyota Field | Elvis Osmanovic | Match Report | |
| Sat | 2022-03-12 | 19:30 | Louisville City | 1–0 | Atlanta 2 | 8,318 | Lynn Family Stadium | Melvin Rivas | Match Report | |
| Sat | 2022-03-12 | 19:30 | RGV Toros | 1–0 | Roots | 5,132 | H-E-B Park | Brandon Stevis | Match Report | |
| Wed | 2022-03-16 | 19:30 | Atlanta 2 | 0–1 | NY Red Bulls II | 435 | Fifth Third Bank Stadium | Sergii Demianchuk | Match Report | |
| Sat | 2022-03-19 | 13:00 | NY Red Bulls II | 0–3 | Loudoun Utd | 460 | MSU Soccer Park at Pittser Field | Jervis Atagana | Match Report | |
| Sat | 2022-03-19 | 16:00 | Detroit City | 1–0 | Charleston | 5,344 | Keyworth Stadium | Elton Garcia | Match Report | |
| Sat | 2022-03-19 | 16:00 | Galaxy II | 1–2 | San Antonio | 500 | Dignity Health Sports Park | DeShun Beard | Match Report | |
| Sat | 2022-03-19 | 18:00 | Memphis | 2–1 | Roots | 3,023 | AutoZone Park | Ben Meyer | Match Report | |
| Sat | 2022-03-19 | 19:00 | Pittsburgh | 2–1 | Hartford | 2,776 | Highmark Stadium | John Matto | Match Report | |
| Sat | 2022-03-19 | 19:30 | Louisville City | 2–0 | Miami FC | 8,846 | Lynn Family Stadium | Gerald Flores | Match Report | |
| Sat | 2022-03-19 | 19:30 | TB Rowdies | 2–0 | Indy Eleven | 5,192 | Al Lang Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-03-19 | 18:00 | CS Switchbacks | 1–0 | Monterey Bay | 5,292 | Weidner Field | Brad Jensen | Match Report | |
| Sat | 2022-03-19 | 19:00 | LV Lights FC | 2–1 | Phx Rising | Cashman Field | Joseph Salinas | Match Report | ||
| Sat | 2022-03-19 | 19:00 | Orange County | 2–1 | RGV Toros | 5,061 | Orange Country Great Park Championship S... | Elijio Arreguin | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-03-19 | 19:00 | El Paso | 1–2 | New Mexico Utd | 8,124 | Southwest University Park | Malik Badawi | Match Report | |
| Sat | 2022-03-19 | 19:00 | Loyal | 2–0 | Sac Republic | 3,900 | Torero Stadium | Greg Dopka | Match Report | |
| Sat | 2022-03-19 | 19:30 | FC Tulsa | 3–1 | B'ham Legion | 4,531 | ONEOK Field | Gabriele Giusti | Match Report | |
| Wed | 2022-03-23 | 19:00 | NY Red Bulls II | 0–2 | Louisville City | 182 | MSU Soccer Park at Pittser Field | Adam Kilpatrick | Match Report | |
| Wed | 2022-03-23 | 19:30 | Atlanta 2 | 0–3 | TB Rowdies | 663 | Fifth Third Bank Stadium | Chris Ruska | Match Report | |
| Wed | 2022-03-23 | 19:30 | Galaxy II | 1–0 | RGV Toros | Dignity Health Sports Park | Ricardo Fierro | Match Report | ||
| Wed | 2022-03-23 | 19:30 | FC Tulsa | 1–0 | Loyal | 3,203 | ONEOK Field | Kevin Broadley | Match Report | |
| Wed | 2022-03-23 | 20:00 | El Paso | 4–5 | LV Lights FC | 5,077 | Southwest University Park | Brandon Stevis | Match Report | |
| Sat | 2022-03-26 | 16:00 | Detroit City | 1–1 | Pittsburgh | 4,733 | Keyworth Stadium | Adam Kilpatrick | Match Report | |
| Sat | 2022-03-26 | 16:00 | New Mexico Utd | 1–1 | Orange County | 10,676 | Isotopes Park | Calin Radosav | Match Report | |
| Sat | 2022-03-26 | 18:30 | B'ham Legion | 0–2 | CS Switchbacks | 5,122 | Protective Stadium | Izlen Peksenar | Match Report | |
| Sat | 2022-03-26 | 19:00 | Miami FC | 0–0 | Loudoun Utd | 1,174 | Riccardo Silva Stadium | Jalen Gray | Match Report | |
| Sat | 2022-03-26 | 19:30 | Louisville City | 1–1 | Indy Eleven | 8,551 | Lynn Family Stadium | Eric Tattersall | Match Report | |
| Sat | 2022-03-26 | 19:30 | TB Rowdies | 1–1 | Hartford | 60,061 | Al Lang Stadium | Elvis Osmanovic | Match Report | |
| Sun | 2022-03-27 | 14:00 | Sac Republic | 2–1 | FC Tulsa | 8,706 | Heart Health Park | Joseph Salinas | Match Report | |
| Sun | 2022-03-27 | 18:30 | RGV Toros | 1–2 | San Antonio | 3,759 | H-E-B Park | Jeremy Scheer | Match Report | |
| Sat | 2022-03-26 | 19:00 | Roots | 2–3 | Monterey Bay | 5,508 | Laney College Field | DeShun Beard | Match Report | |
| Sat | 2022-03-26 | 19:00 | LV Lights FC | 0–1 | Memphis | 5,391 | Cashman Field | Kevin Fikar | Match Report | |
| Sat | 2022-03-26 | 19:30 | Phx Rising | 2–3 | Loyal | 7,321 | Wild Horse Pass Stadium | Elton Garcia | Match Report | |
| Sun | 2022-03-27 | 19:30 | Atlanta 2 | 4–1 | Charleston | 624 | Fifth Third Bank Stadium | Kyle Johnston | Match Report | |
| Wed | 2022-03-30 | 19:00 | New Mexico Utd | 2–2 | Roots | 7,731 | Isotopes Park | Ricardo Fierro | Match Report | |
| Fri | 2022-04-01 | 19:00 | Charleston | 1–2 | LV Lights FC | 2,934 | Patriots Point Soccer Complex | Sergii Demianchuk | Match Report | |
| Sat | 2022-04-02 | 16:00 | Detroit City | 1–1 | Memphis | 4,157 | Keyworth Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-04-02 | 18:30 | B'ham Legion | 0–0 | Louisville City | 5,075 | Protective Stadium | Elton Garcia | Match Report | |
| Sat | 2022-04-02 | 19:00 | Hartford | 1–2 | Atlanta 2 | 5,022 | Dillon Stadium | Christian Centeno | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-02 | 19:00 | Pittsburgh | 2–0 | Loudoun Utd | 2,456 | Highmark Stadium | Austin Saini | Match Report | |
| Sat | 2022-04-02 | 19:00 | Indy Eleven | 1–1 | Galaxy II | 8,037 | Michael A. Carroll Stadium | Nabil Bensalah | Match Report | |
| Sat | 2022-04-02 | 19:00 | Miami FC | 1–2 | CS Switchbacks | 1,083 | Riccardo Silva Stadium | Elvis Osmanovic | Match Report | |
| Sun | 2022-04-03 | 14:00 | Loyal | 3–2 | El Paso | 3,800 | Torero Stadium | Matthew Thompson | Match Report | |
| Sat | 2022-04-02 | 19:00 | Roots | 0–0 | TB Rowdies | 4,124 | Laney College Field | Luis Guardia | Match Report | |
| Sat | 2022-04-02 | 19:00 | Sac Republic | 2–1 | Monterey Bay | 10,241 | Heart Health Park | Malik Badawi | Match Report | |
| Sat | 2022-04-02 | 19:30 | San Antonio | 0–2 | Phx Rising | 5,511 | Toyota Field | Eric Tattersall | Match Report | |
| Sat | 2022-04-02 | 19:30 | FC Tulsa | 3–2 | NY Red Bulls II | 4,082 | ONEOK Field | John Matto | Match Report | |
| Sat | 2022-04-09 | 13:00 | FC Tulsa | 3–4 | Pittsburgh | 2,851 | ONEOK Field | Jalen Gray | Match Report | |
| Sat | 2022-04-09 | 14:00 | LV Lights FC | 2–3 | CS Switchbacks | 4,922 | Cashman Field | Matt Conger | Match Report | |
| Sat | 2022-04-09 | 19:30 | TB Rowdies | 0–1 | Miami FC | 4,947 | Al Lang Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-04-09 | 19:30 | Atlanta 2 | 0–4 | Detroit City | 574 | Fifth Third Bank Stadium | Jordan Gray | Match Report | |
| Sun | 2022-04-10 | 16:00 | B'ham Legion | 2–1 | Hartford | 4,207 | Protective Stadium | Sergii Demianchuk | Match Report | |
| Sun | 2022-04-10 | 16:00 | Loudoun Utd | 0–2 | Louisville City | 1,444 | Segra Field | Luis Arroyo | Match Report | |
| Sat | 2022-04-09 | 19:00 | Loyal | 4–1 | Charleston | 3,400 | Torero Stadium | Brandon Stevis | Match Report | |
| Sat | 2022-04-09 | 19:00 | Orange County | 0–1 | San Antonio | 4,167 | Orange Country Great Park Championship S... | Ricardo Fierro | Match Report | |
| Sat | 2022-04-09 | 19:30 | Phx Rising | 3–1 | Galaxy II | 8,019 | Wild Horse Pass Stadium | Luis Guardia | Match Report | |
| Sat | 2022-04-09 | 19:30 | RGV Toros | 1–2 | Indy Eleven | 3,357 | H-E-B Park | Gerald Flores | Match Report | |
| Sat | 2022-04-09 | 20:30 | El Paso | 5–0 | Monterey Bay | 7,148 | Southwest University Park | Jervis Atagana | Match Report | |
| Wed | 2022-04-13 | 19:00 | Roots | 2–2 | Loyal | 4,017 | Laney College Field | Malik Badawi | Match Report | |
| Fri | 2022-04-15 | 19:00 | NY Red Bulls II | 0–1 | RGV Toros | 259 | MSU Soccer Park at Pittser Field | Thomas Snyder | Match Report | |
| Fri | 2022-04-15 | 19:00 | Detroit City | 1–0 | B'ham Legion | 4,505 | Keyworth Stadium | Matthew Franz | Match Report | |
| Sat | 2022-04-16 | 16:00 | LV Lights FC | 1–0 | Pittsburgh | 4,420 | Cashman Field | Jervis Atagana | Match Report | |
| Sat | 2022-04-16 | 19:00 | Indy Eleven | 2–1 | Atlanta 2 | 5,906 | Michael A. Carroll Stadium | Calin Radosav | Match Report | |
| Sat | 2022-04-16 | 19:00 | Miami FC | 2–0 | Hartford | 1,102 | Riccardo Silva Stadium | Joshua Encarnacion | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-16 | 19:30 | TB Rowdies | 3–1 | FC Tulsa | 5,067 | Al Lang Stadium | Elijio Arreguin | Match Report | |
| Sat | 2022-04-16 | 18:00 | CS Switchbacks | 1–2 | Memphis | 7,334 | Weidner Field | Elton Garcia | Match Report | |
| Sat | 2022-04-16 | 19:00 | Orange County | 1–1 | Sac Republic | 3,692 | Orange Country Great Park Championship S... | Melvin Rivas | Match Report | |
| Sat | 2022-04-16 | 19:00 | Roots | 4–1 | Loudoun Utd | 3,807 | Laney College Field | Lorenzo Hernandez | Match Report | |
| Sat | 2022-04-16 | 19:00 | Loyal | 2–5 | Louisville City | 3,482 | Torero Stadium | Michael Radchuk | Match Report | |
| Sat | 2022-04-16 | 19:30 | San Antonio | 1–0 | El Paso | 5,167 | Toyota Field | Luis Guardia | Match Report | |
| Sat | 2022-04-16 | 19:30 | Galaxy II | 3–1 | Monterey Bay | Dignity Health Sports Park | Ben Meyer | Match Report | ||
| Sat | 2022-04-16 | 19:30 | Phx Rising | 1–0 | New Mexico Utd | 7,011 | Wild Horse Pass Stadium | Gerald Flores | Match Report | |
| Sat | 2022-04-23 | 13:00 | NY Red Bulls II | 1–1 | TB Rowdies | 314 | MSU Soccer Park at Pittser Field | Matthew Thompson | Match Report | |
| Sat | 2022-04-23 | 17:00 | Charleston | 1–1 | Louisville City | 3,044 | Patriots Point Soccer Complex | Gabriele Giusti | Match Report | |
| Sat | 2022-04-23 | 19:00 | Hartford | 1–2 | Detroit City | 4,939 | Dillon Stadium | Luis Arroyo | Match Report | |
| Sat | 2022-04-23 | 19:00 | Pittsburgh | 4–0 | Atlanta 2 | 5,202 | Highmark Stadium | Kevin Fikar | Match Report | |
| Sun | 2022-04-24 | 16:00 | Loudoun Utd | 1–2 | B'ham Legion | 1,523 | Segra Field | Elvis Osmanovic | Match Report | |
| Sun | 2022-04-24 | 17:30 | Indy Eleven | 3–1 | Orange County | 5,736 | Michael A. Carroll Stadium | Elijio Arreguin | Match Report | |
| Sat | 2022-04-23 | 19:00 | LV Lights FC | 1–1 | Galaxy II | 8,052 | Cashman Field | Calin Radosav | Match Report | |
| Sat | 2022-04-23 | 19:00 | New Mexico Utd | 0–1 | San Antonio | 11,420 | Isotopes Park | Michael Radchuk | Match Report | |
| Sat | 2022-04-23 | 19:30 | RGV Toros | 2–1 | Sac Republic | 3,635 | H-E-B Park | Elton Garcia | Match Report | |
| Sat | 2022-04-23 | 19:30 | FC Tulsa | 0–2 | CS Switchbacks | 3,222 | ONEOK Field | Mathew Corrigan | Match Report | |
| Sat | 2022-04-23 | 19:30 | Phx Rising | 2–1 | Miami FC | 6,785 | Wild Horse Pass Stadium | Melvin Rivas | Match Report | |
| Sat | 2022-04-23 | 20:30 | El Paso | 1–1 | Roots | 5,727 | Southwest University Park | Mark Allatin | Match Report | |
| Wed | 2022-04-27 | 19:00 | B'ham Legion | 2–1 | Charleston | Protective Stadium | Jeremy Scheer | Match Report | ||
| Wed | 2022-04-27 | 19:00 | Memphis | 3–1 | TB Rowdies | AutoZone Park | Jervis Atagana | Match Report | ||
| Sat | 2022-04-30 | 16:00 | Detroit City | 2–0 | NY Red Bulls II | Keyworth Stadium | Eric Tattersall | Match Report | ||
| Sat | 2022-04-30 | 18:00 | Loudoun Utd | 1–3 | El Paso | 1,282 | Segra Field | Matthew Franz | Match Report | |
| Sat | 2022-04-30 | 19:00 | Indy Eleven | 1–0 | Hartford | 4,695 | Michael A. Carroll Stadium | Greg Dopka | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-30 | 19:30 | TB Rowdies | 2–3 | Loyal | 5,039 | Al Lang Stadium | Sergii Demianchuk | Match Report | |
| Sat | 2022-04-30 | 19:30 | Louisville City | 2–0 | Pittsburgh | 11,093 | Lynn Family Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2022-04-30 | 19:00 | Memphis | 1–2 | Miami FC | 3,706 | AutoZone Park | John Griggs | Match Report | |
| Sat | 2022-04-30 | 19:00 | Roots | 0–3 | CS Switchbacks | 5,382 | Laney College Field | Michael Radchuk | Match Report | |
| Sat | 2022-04-30 | 19:00 | Sac Republic | 1–1 | LV Lights FC | 10,078 | Heart Health Park | Brad Jensen | Match Report | |
| Sat | 2022-04-30 | 19:30 | San Antonio | 6–0 | Monterey Bay | 6,638 | Toyota Field | Katja Koroleva | Match Report | |
| Sat | 2022-04-30 | 19:30 | RGV Toros | 1–2 | Orange County | 3,316 | H-E-B Park | Mathew Corrigan | Match Report | |
| Sun | 2022-05-01 | 17:00 | Galaxy II | 3–0 | Phx Rising | Dignity Health Sports Park | Mark Allatin | Match Report | ||
| Wed | 2022-05-04 | 19:30 | Atlanta 2 | 0–4 | Louisville City | 640 | Fifth Third Bank Stadium | Kyle Johnston | Match Report | |
| Wed | 2022-05-04 | 19:00 | Sac Republic | 0–0 | New Mexico Utd | 7,835 | Heart Health Park | Ricardo Fierro | Match Report | |
| Wed | 2022-05-04 | 19:00 | B'ham Legion | 0–0 | Miami FC | Protective Stadium | Adam Kilpatrick | Match Report | ||
| Wed | 2022-05-04 | 20:00 | El Paso | 3–1 | FC Tulsa | 5,381 | Southwest University Park | Elton Garcia | Match Report | |
| Thu | 2022-05-05 | 19:00 | CS Switchbacks | 3–2 | RGV Toros | 7,128 | Weidner Field | Malik Badawi | Match Report | |
| Fri | 2022-05-06 | 19:00 | Charleston | 0–2 | Memphis | 3,026 | Patriots Point Soccer Complex | Kevin Broadley | Match Report | |
| Sat | 2022-05-07 | 17:00 | New Mexico Utd | 1–1 | Loyal | 12,079 | Isotopes Park | Mark Allatin | Match Report | |
| Sat | 2022-05-07 | 19:00 | Hartford | 1–0 | Loudoun Utd | 4,631 | Dillon Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-05-07 | 19:00 | Pittsburgh | 1–0 | B'ham Legion | 3,479 | Highmark Stadium | Joshua Encarnacion | Match Report | |
| Sun | 2022-05-08 | 13:00 | NY Red Bulls II | 0–1 | Sac Republic | 201 | MSU Soccer Park at Pittser Field | Matthew Franz | Match Report | |
| Sat | 2022-05-07 | 19:00 | Monterey Bay | 1–0 | LV Lights FC | 4,687 | Cardinale Stadium | Elijio Arreguin | Match Report | |
| Sat | 2022-05-07 | 19:00 | Orange County | 2–2 | Roots | 4,084 | Orange Country Great Park Championship S... | Elton Garcia | Match Report | |
| Sat | 2022-05-07 | 19:30 | Phx Rising | 3–0 | San Antonio | 6,486 | Wild Horse Pass Stadium | Calin Radosav | Match Report | |
| Sat | 2022-05-07 | 19:30 | FC Tulsa | 3–1 | Detroit City | 4,311 | ONEOK Field | Brandon Stevis | Match Report | |
| Sat | 2022-05-07 | 20:30 | El Paso | 4–0 | Galaxy II | 6,378 | Southwest University Park | Matthew Thompson | Match Report | |
| Sat | 2022-05-14 | 19:00 | Charleston | 0–2 | New Mexico Utd | 2,744 | Patriots Point Soccer Complex | Adam Kilpatrick | Match Report | |
| Sat | 2022-05-14 | 19:00 | Pittsburgh | 1–0 | El Paso | 3,749 | Highmark Stadium | Kevin Fikar | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-05-14 | 19:00 | Miami FC | 0–2 | San Antonio | 1,307 | Riccardo Silva Stadium | Gerald Flores | Match Report | |
| Sat | 2022-05-14 | 19:00 | Hartford | 3–2 | NY Red Bulls II | 5,500 | Dillon Stadium | José Carlos Rivero | Match Report | |
| Fri | 2022-05-13 | 19:00 | Orange County | 5–1 | FC Tulsa | 4,020 | Orange Country Great Park Championship S... | Greg Dopka | Match Report | |
| Sat | 2022-05-14 | 19:30 | Detroit City | 4–2 | Loudoun Utd | 5,256 | Keyworth Stadium | Austin Saini | Match Report | |
| Fri | 2022-05-13 | 19:30 | Galaxy II | 4–3 | Louisville City | Dignity Health Sports Park | Brandon Stevis | Match Report | ||
| Sat | 2022-05-14 | 19:00 | Memphis | 2–1 | Indy Eleven | 3,515 | AutoZone Park | Matthew Thompson | Match Report | |
| Sat | 2022-05-14 | 19:00 | LV Lights FC | 1–1 | Roots | Cashman Field | Malik Badawi | Match Report | ||
| Sat | 2022-05-14 | 19:00 | Monterey Bay | 1–2 | RGV Toros | 3,078 | Cardinale Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-05-15 | 19:00 | Phx Rising | 1–5 | TB Rowdies | Wild Horse Pass Stadium | Matthew Franz | Match Report | ||
| Wed | 2022-05-18 | 19:00 | Miami FC | 1–1 | Detroit City | 853 | Riccardo Silva Stadium | Alejo Calume | Match Report | |
| Wed | 2022-05-18 | 19:00 | Memphis | 5–0 | Galaxy II | 2,768 | AutoZone Park | Jervis Atagana | Match Report | |
| Wed | 2022-05-18 | 19:00 | B'ham Legion | 0–0 | LV Lights FC | Protective Stadium | Ben Meyer | Match Report | ||
| Wed | 2022-05-18 | 20:00 | El Paso | 1–0 | Sac Republic | 5,521 | Southwest University Park | Mathew Corrigan | Match Report | |
| Sat | 2022-05-21 | 19:00 | Indy Eleven | 2–0 | NY Red Bulls II | 6,217 | Michael A. Carroll Stadium | Kevin Fikar | Match Report | |
| Sat | 2022-05-21 | 19:00 | Charleston | 0–4 | Miami FC | 3,380 | Patriots Point Soccer Complex | Izlen Peksenar | Match Report | |
| Sat | 2022-05-21 | 19:30 | Detroit City | 3–1 | Atlanta 2 | 5,483 | Keyworth Stadium | Alex Billeter | Match Report | |
| Sat | 2022-05-21 | 19:30 | TB Rowdies | 3–1 | Pittsburgh | 5,102 | Al Lang Stadium | Eric Tattersall | Match Report | |
| Sat | 2022-05-21 | 19:30 | Louisville City | 0–2 | Monterey Bay | 10,617 | Lynn Family Stadium | Nabil Bensalah | Match Report | |
| Sun | 2022-05-22 | 17:30 | Loudoun Utd | 0–3 | Memphis | 1,106 | Segra Field | Jeremy Scheer | Match Report | |
| Sat | 2022-05-21 | 19:00 | Roots | 1–0 | Galaxy II | 4,421 | Laney College Field | John Griggs | Match Report | |
| Sat | 2022-05-21 | 19:00 | Orange County | 2–2 | El Paso | 4,477 | Orange Country Great Park Championship S... | Natalie Simon | Match Report | |
| Sat | 2022-05-21 | 19:30 | RGV Toros | 2–1 | Loyal | 3,500 | H-E-B Park | Matthew Franz | Match Report | |
| Tue | 2022-05-24 | 19:00 | New Mexico Utd | 7–0 | Phx Rising | Isotopes Park | Brad Jensen | Match Report | ||
| Fri | 2022-05-27 | 19:00 | NY Red Bulls II | 1–2 | B'ham Legion | 246 | MSU Soccer Park at Pittser Field | José Carlos Rivero | Match Report | |
| Fri | 2022-05-27 | 19:30 | Atlanta 2 | 0–0 | Orange County | 749 | Fifth Third Bank Stadium | Alyssa Nichols | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-05-28 | 14:00 | Louisville City | 4–1 | FC Tulsa | 9,326 | Lynn Family Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-05-28 | 16:00 | Indy Eleven | 1–2 | New Mexico Utd | 6,915 | Michael A. Carroll Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2022-05-28 | 19:00 | Hartford | 1–2 | Phx Rising | Dillon Stadium | Luis Arroyo | Match Report | ||
| Fri | 2022-05-27 | 19:00 | LV Lights FC | 0–1 | El Paso | Cashman Field | Mark Allatin | Match Report | ||
| Sat | 2022-05-28 | 19:00 | Miami FC | 2–2 | Pittsburgh | 937 | Riccardo Silva Stadium | Alejo Calume | Match Report | |
| Sat | 2022-05-28 | 19:00 | Loudoun Utd | 1–1 | Charleston | 1,253 | Segra Field | John Griggs | Match Report | |
| Sat | 2022-05-28 | 19:00 | Monterey Bay | 4–2 | CS Switchbacks | Cardinale Stadium | Corbyn May | Match Report | ||
| Sat | 2022-05-28 | 19:00 | Roots | 1–1 | Sac Republic | 4,268 | Laney College Field | Greg Dopka | Match Report | |
| Sat | 2022-05-28 | 19:30 | Galaxy II | 2–2 | Loyal | Dignity Health Sports Park | Matt Conger | Match Report | ||
| Sat | 2022-05-28 | 19:30 | RGV Toros | 2–3 | San Antonio | 3,053 | H-E-B Park | Melvin Rivas | Match Report | |
| Wed | 2022-06-01 | 19:30 | Atlanta 2 | 3–4 | RGV Toros | 584 | Fifth Third Bank Stadium | Izlen Peksenar | Match Report | |
| Thu | 2022-06-02 | 17:00 | NY Red Bulls II | 2–2 | Loyal | 112 | MSU Soccer Park at Pittser Field | Jeremy Scheer | Match Report | |
| Wed | 2022-06-01 | 19:00 | Roots | 3–2 | Orange County | 3,092 | Laney College Field | Ricardo Fierro | Match Report | |
| Wed | 2022-06-01 | 19:30 | FC Tulsa | 1–1 | TB Rowdies | 2,549 | ONEOK Field | Mathew Corrigan | Match Report | |
| Fri | 2022-06-03 | 19:00 | CS Switchbacks | 3–0 | LV Lights FC | 7,650 | Weidner Field | Brad Jensen | Match Report | |
| Sat | 2022-06-04 | 19:00 | Charleston | 3–4 | Indy Eleven | 1,849 | Patriots Point Soccer Complex | Chris Ruska | Match Report | |
| Sat | 2022-06-04 | 19:00 | Pittsburgh | 1–1 | Detroit City | 4,273 | Highmark Stadium | Luis Arroyo | Match Report | |
| Sat | 2022-06-04 | 18:00 | Orange County | 1–2 | New Mexico Utd | 5,135 | Orange Country Great Park Championship S... | Mark Allatin | Match Report | |
| Sat | 2022-06-04 | 19:00 | Monterey Bay | 0–2 | Roots | 3,517 | Cardinale Stadium | Brandon Stevis | Match Report | |
| Sat | 2022-06-04 | 19:30 | FC Tulsa | 0–0 | Miami FC | 3,506 | ONEOK Field | DeShun Beard | Match Report | |
| Sat | 2022-06-04 | 19:30 | Phx Rising | 0–1 | B'ham Legion | Wild Horse Pass Stadium | Gerald Flores | Match Report | ||
| Sat | 2022-06-04 | 19:30 | Memphis | 5–2 | Atlanta 2 | 6,073 | AutoZone Park | Thomas Snyder | Match Report | |
| Sat | 2022-06-04 | 19:30 | RGV Toros | 0–1 | Galaxy II | 3,335 | H-E-B Park | Calin Radosav | Match Report | |
| Sun | 2022-06-05 | 19:30 | TB Rowdies | 1–0 | Louisville City | 4,119 | Al Lang Stadium | Matt Conger | Match Report | |
| Sat | 2022-06-04 | 20:00 | Sac Republic | 1–0 | San Antonio | 9,641 | Heart Health Park | Michael Radchuk | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-04 | 20:30 | El Paso | 1–1 | Hartford | 6,715 | Southwest University Park | Joshua Encarnacion | Match Report | |
| Wed | 2022-06-08 | 19:00 | Miami FC | 1–1 | Indy Eleven | Riccardo Silva Stadium | John Matto | Match Report | ||
| Wed | 2022-06-08 | 19:30 | Loudoun Utd | 1–0 | NY Red Bulls II | 1,037 | Segra Field | Jalen Gray | Match Report | |
| Wed | 2022-06-08 | 19:00 | B'ham Legion | 1–0 | Memphis | Protective Stadium | Abdou Ndiaye | Match Report | ||
| Sat | 2022-06-11 | 15:00 | Monterey Bay | 2–3 | San Antonio | 3,110 | Cardinale Stadium | Ricardo Fierro | Match Report | |
| Sat | 2022-06-11 | 19:00 | Charleston | 3–0 | Pittsburgh | 2,272 | Patriots Point Soccer Complex | Natalie Simon | Match Report | |
| Sat | 2022-06-11 | 19:00 | Miami FC | 1–2 | TB Rowdies | 1,382 | Riccardo Silva Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2022-06-11 | 19:30 | Atlanta 2 | 2–0 | Loudoun Utd | 339 | Fifth Third Bank Stadium | Adorae Monroy | Match Report | |
| Sat | 2022-06-11 | 19:30 | Detroit City | 0–2 | Sac Republic | 7,011 | Keyworth Stadium | Austin Saini | Match Report | |
| Sat | 2022-06-11 | 19:00 | Loyal | 3–0 | Hartford | 4,112 | Torero Stadium | Malik Badawi | Match Report | |
| Sat | 2022-06-11 | 19:00 | Roots | 2–2 | RGV Toros | 4,215 | Laney College Field | Joseph Salinas | Match Report | |
| Sat | 2022-06-11 | 19:30 | Galaxy II | 1–3 | CS Switchbacks | Dignity Health Sports Park | Mathew Corrigan | Match Report | ||
| Sat | 2022-06-11 | 19:30 | Phx Rising | 0–1 | El Paso | Wild Horse Pass Stadium | Elijio Arreguin | Match Report | ||
| Sat | 2022-06-11 | 19:30 | LV Lights FC | 3–0 | Orange County | Cashman Field | Benjamin Meyer | Match Report | ||
| Wed | 2022-06-15 | 19:00 | Hartford | 1–1 | Memphis | 5,472 | Dillon Stadium | Austin Saini | Match Report | |
| Wed | 2022-06-15 | 19:00 | NY Red Bulls II | 0–0 | FC Tulsa | 442 | MSU Soccer Park at Pittser Field | Alejo Calume | Match Report | |
| Wed | 2022-06-15 | 19:00 | Roots | 1–2 | New Mexico Utd | 3,752 | Laney College Field | Gerald Flores | Match Report | |
| Wed | 2022-06-15 | 19:30 | Galaxy II | 3–2 | Monterey Bay | 150 | Dignity Health Sports Park | Adam Kilpatrick | Match Report | |
| Sat | 2022-06-18 | 12:00 | Detroit City | 1–1 | El Paso | 7,267 | Keyworth Stadium | Matt Conger | Match Report | |
| Sat | 2022-06-18 | 19:30 | Atlanta 2 | 0–3 | Hartford | 532 | Fifth Third Bank Stadium | Natalie Simon | Match Report | |
| Sat | 2022-06-18 | 19:30 | TB Rowdies | 1–1 | Charleston | 4,569 | Al Lang Stadium | Alejo Calume | Match Report | |
| Sat | 2022-06-18 | 19:30 | Loudoun Utd | 4–3 | Phx Rising | 1,588 | Segra Field | Joshua Encarnacion | Match Report | |
| Sun | 2022-06-19 | 15:00 | Loyal | 1–2 | LV Lights FC | 5,124 | Torero Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2022-06-18 | 19:00 | CS Switchbacks | 4–3 | Indy Eleven | 8,023 | Weidner Field | Elijio Arreguin | Match Report | |
| Sat | 2022-06-18 | 19:30 | RGV Toros | 1–0 | Pittsburgh | 4,083 | H-E-B Park | Brandon Stevis | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-18 | 20:00 | San Antonio | 1–1 | Roots | 5,563 | Toyota Field | Brad Jensen | Match Report | |
| Sat | 2022-06-18 | 20:00 | Sac Republic | 2–0 | Galaxy II | 10,691 | Heart Health Park | Mark Allatin | Match Report | |
| Sat | 2022-06-18 | 20:00 | Louisville City | 3–1 | Orange County | 10,848 | Lynn Family Stadium | Kevin Broadley | Match Report | |
| Wed | 2022-06-22 | 19:00 | Memphis | 2–0 | FC Tulsa | 2,710 | AutoZone Park | Greg Dopka | Match Report | |
| Sat | 2022-06-25 | 13:00 | Hartford | 0–2 | Louisville City | Dillon Stadium | Calin Radosav | Match Report | ||
| Sat | 2022-06-25 | 19:00 | Pittsburgh | 2–5 | TB Rowdies | 3,888 | Highmark Stadium | Adam Kilpatrick | Match Report | |
| Sat | 2022-06-25 | 19:00 | Miami FC | 1–3 | Galaxy II | 1,254 | Riccardo Silva Stadium | Eric Tattersall | Match Report | |
| Fri | 2022-06-24 | 19:00 | CS Switchbacks | 0–1 | San Antonio | 6,733 | Weidner Field | Matt Conger | Match Report | |
| Fri | 2022-06-24 | 19:30 | LV Lights FC | 3–2 | Phx Rising | Cashman Field | Malik Badawi | Match Report | ||
| Sat | 2022-06-25 | 17:00 | Orange County | 3–1 | Loudoun Utd | 4,119 | Orange Country Great Park Championship S... | Joseph Salinas | Match Report | |
| Sat | 2022-06-25 | 19:00 | Monterey Bay | 1–2 | Sac Republic | 3,604 | Cardinale Stadium | Elijio Arreguin | Match Report | |
| Sat | 2022-06-25 | 19:00 | Loyal | 5–0 | Indy Eleven | 5,078 | Torero Stadium | Mathew Corrigan | Match Report | |
| Sat | 2022-06-25 | 19:00 | New Mexico Utd | 0–2 | B'ham Legion | 12,527 | Isotopes Park | Melvin Rivas | Match Report | |
| Sat | 2022-06-25 | 19:00 | Roots | 3–1 | Atlanta 2 | 3,622 | Laney College Field | Corbyn May | Match Report | |
| Sat | 2022-06-25 | 19:30 | FC Tulsa | 2–1 | Charleston | 4,966 | ONEOK Field | Abdou Ndiaye | Match Report | |
| Sat | 2022-06-25 | 19:30 | Memphis | 2–0 | Detroit City | 3,883 | AutoZone Park | Joshua Encarnacion | Match Report | |
| Sat | 2022-06-25 | 20:30 | El Paso | 5–0 | NY Red Bulls II | 6,754 | Southwest University Park | Luis Guardia | Match Report | |
| Tue | 2022-06-28 | 19:00 | Hartford | 2–0 | CS Switchbacks | 5,241 | Dillon Stadium | John Griggs | Match Report | |
| Wed | 2022-06-29 | 19:30 | Charleston | 3–4 | Atlanta 2 | 2,649 | Patriots Point Soccer Complex | John Matto | Match Report | |
| Tue | 2022-06-28 | 20:00 | San Antonio | 2–1 | FC Tulsa | 5,015 | Toyota Field | Matthew Thompson | Match Report | |
| Wed | 2022-06-29 | 19:00 | Loyal | 2–1 | Orange County | 5,146 | Torero Stadium | Ricardo Fierro | Match Report | |
| Wed | 2022-06-29 | 19:30 | RGV Toros | 0–0 | El Paso | 2,519 | H-E-B Park | Gerald Flores | Match Report | |
| Fri | 2022-07-01 | 19:00 | NY Red Bulls II | 0–3 | Pittsburgh | 422 | MSU Soccer Park at Pittser Field | Malik Badawi | Match Report | |
| Fri | 2022-07-01 | 19:00 | CS Switchbacks | 3–0 | Sac Republic | 6,580 | Weidner Field | Joshua Encarnacion | Match Report | |
| Sat | 2022-07-02 | 19:30 | Atlanta 2 | 2–2 | El Paso | 534 | Fifth Third Bank Stadium | José Carlos Rivero | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Fri | 2022-07-01 | 19:30 | Galaxy II | 3–1 | Roots | Dignity Health Sports Park | Jervis Atagana | Match Report | ||
| Sat | 2022-07-02 | 19:30 | Indy Eleven | 0–1 | Miami FC | 8,008 | Michael A. Carroll Stadium | Nabil Bensalah | Match Report | |
| Sat | 2022-07-02 | 19:30 | TB Rowdies | 2–0 | Memphis | 6,175 | Al Lang Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-07-02 | 19:00 | Monterey Bay | 1–1 | New Mexico Utd | 3,114 | Cardinale Stadium | Dejan Susak | Match Report | |
| Sat | 2022-07-02 | 19:30 | Phx Rising | 2–2 | Orange County | Wild Horse Pass Stadium | Michael Radchuk | Match Report | ||
| Sun | 2022-07-03 | 19:30 | Loudoun Utd | 2–2 | FC Tulsa | 1,405 | Segra Field | Wes Caouette | Match Report | |
| Sat | 2022-07-02 | 19:30 | LV Lights FC | 0–1 | Detroit City | Cashman Field | Melvin Rivas | Match Report | ||
| Sat | 2022-07-02 | 20:00 | Louisville City | 2–1 | B'ham Legion | 9,627 | Lynn Family Stadium | John Griggs | Match Report | |
| Sat | 2022-07-02 | 20:00 | San Antonio | 2–0 | Charleston | 7,044 | Toyota Field | Gerald Flores | Match Report | |
| Mon | 2022-07-04 | 19:00 | CS Switchbacks | 2–3 | Loyal | 8,023 | Weidner Field | Calin Radosav | Match Report | |
| Wed | 2022-07-06 | 19:00 | Pittsburgh | 1–0 | Indy Eleven | 2,155 | Highmark Stadium | Matt Conger | Match Report | |
| Wed | 2022-07-06 | 19:30 | Detroit City | 1–1 | Hartford | 5,517 | Keyworth Stadium | Matthew Thompson | Match Report | |
| Wed | 2022-07-06 | 19:30 | Atlanta 2 | 3–3 | B'ham Legion | 551 | Fifth Third Bank Stadium | DeShun Beard | Match Report | |
| Wed | 2022-07-06 | 19:00 | New Mexico Utd | 1–0 | RGV Toros | Isotopes Park | Kevin Stott | Match Report | ||
| Sat | 2022-07-09 | 19:00 | Hartford | 2–3 | TB Rowdies | 5,090 | Dillon Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2022-07-09 | 19:00 | Pittsburgh | 4–1 | Miami FC | 4,703 | Highmark Stadium | Gerald Flores | Match Report | |
| Sat | 2022-07-09 | 19:00 | Indy Eleven | 0–1 | Detroit City | 9,462 | Michael A. Carroll Stadium | Benjamin Meyer | Match Report | |
| Sat | 2022-07-09 | 19:00 | Orange County | 0–2 | Monterey Bay | 4,008 | Orange Country Great Park Championship S... | Elvis Osmanovic | Match Report | |
| Sat | 2022-07-09 | 19:00 | Loyal | 0–5 | Galaxy II | 5,425 | Torero Stadium | Dejan Susak | Match Report | |
| Sat | 2022-07-09 | 19:00 | New Mexico Utd | 1–1 | RGV Toros | 10,781 | Isotopes Park | Elijio Arreguin | Match Report | |
| Sat | 2022-07-09 | 19:30 | FC Tulsa | 2–1 | Atlanta 2 | 4,053 | ONEOK Field | Lorenzo Hernandez | Match Report | |
| Sat | 2022-07-09 | 19:30 | Memphis | 3–1 | Phx Rising | 3,703 | AutoZone Park | Matt Conger | Match Report | |
| Sat | 2022-07-09 | 20:00 | Louisville City | 6–0 | NY Red Bulls II | 10,462 | Lynn Family Stadium | Nabil Bensalah | Match Report | |
| Sat | 2022-07-09 | 20:00 | Charleston | 0–3 | B'ham Legion | 2,214 | Patriots Point Soccer Complex | Alex Billeter | Match Report | |
| Sat | 2022-07-09 | 20:00 | Sac Republic | 3–3 | Roots | 10,169 | Heart Health Park | Elton Garcia | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-09 | 20:30 | El Paso | 1–0 | CS Switchbacks | 7,009 | Southwest University Park | Adam Kilpatrick | Match Report | |
| Wed | 2022-07-13 | 19:00 | Miami FC | 1–0 | Charleston | 752 | Riccardo Silva Stadium | Natalie Simon | Match Report | |
| Wed | 2022-07-13 | 19:30 | FC Tulsa | 1–2 | New Mexico Utd | 4,607 | ONEOK Field | Jervis Atagana | Match Report | |
| Fri | 2022-07-15 | 19:00 | NY Red Bulls II | 1–0 | Indy Eleven | 424 | MSU Soccer Park at Pittser Field | Melvin Rivas | Match Report | |
| Fri | 2022-07-15 | 19:00 | CS Switchbacks | 4–2 | Galaxy II | 8,023 | Weidner Field | Matthew Thompson | Match Report | |
| Sat | 2022-07-16 | 19:30 | Loudoun Utd | 1–4 | TB Rowdies | 1,613 | Segra Field | Esad Omanovic | Match Report | |
| Sat | 2022-07-16 | 17:00 | Orange County | 0–0 | Miami FC | 3,869 | Orange Country Great Park Championship S... | Brandon Stevis | Match Report | |
| Sun | 2022-07-17 | 18:30 | RGV Toros | 0–1 | LV Lights FC | 5,069 | H-E-B Park | Gabriele Giusti | Match Report | |
| Sat | 2022-07-16 | 19:00 | Roots | 4–0 | El Paso | 4,221 | Laney College Field | Lorenzo Hernandez | Match Report | |
| Sat | 2022-07-16 | 19:00 | New Mexico Utd | 1–1 | Pittsburgh | 12,069 | Isotopes Park | Greg Dopka | Match Report | |
| Sat | 2022-07-16 | 19:00 | Monterey Bay | 0–0 | Detroit City | 3,357 | Cardinale Stadium | Mark Allatin | Match Report | |
| Sat | 2022-07-16 | 19:30 | Memphis | 1–2 | Louisville City | 4,834 | AutoZone Park | Michael Radchuk | Match Report | |
| Sat | 2022-07-16 | 20:00 | San Antonio | 5–0 | Atlanta 2 | 5,716 | Toyota Field | Abdou Ndiaye | Match Report | |
| Sat | 2022-07-16 | 20:00 | Charleston | 3–1 | Hartford | 1,998 | Patriots Point Soccer Complex | Sergii Demianchuk | Match Report | |
| Sat | 2022-07-16 | 20:00 | Sac Republic | 0–1 | B'ham Legion | 9,161 | Heart Health Park | Corbyn May | Match Report | |
| Mon | 2022-07-18 | 19:00 | Loyal | 3–0 | CS Switchbacks | 4,299 | Torero Stadium | Malik Badawi | Match Report | |
| Wed | 2022-07-20 | 19:00 | Louisville City | 0–0 | Phx Rising | 10,494 | Lynn Family Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-07-23 | 18:30 | B'ham Legion | 0–2 | FC Tulsa | Protective Stadium | Benjamin Meyer | Match Report | ||
| Fri | 2022-07-22 | 19:00 | CS Switchbacks | 3–3 | Charleston | 6,979 | Weidner Field | Mathew Corrigan | Match Report | |
| Sat | 2022-07-23 | 19:00 | Hartford | 1–2 | Pittsburgh | 4,628 | Dillon Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-07-23 | 19:00 | Indy Eleven | 1–1 | Memphis | 9,020 | Michael A. Carroll Stadium | Natalie Simon | Match Report | |
| Sat | 2022-07-23 | 19:30 | TB Rowdies | 3–1 | Atlanta 2 | 4,890 | Al Lang Stadium | Adam Kilpatrick | Match Report | |
| Sat | 2022-07-23 | 19:30 | Detroit City | 2–2 | New Mexico Utd | 7,470 | Keyworth Stadium | Malik Badawi | Match Report | |
| Sat | 2022-07-23 | 19:00 | Monterey Bay | 2–0 | NY Red Bulls II | 3,116 | Cardinale Stadium | Katja Koroleva | Match Report | |
| Sat | 2022-07-23 | 19:00 | Roots | 0–2 | LV Lights FC | 3,941 | Laney College Field | Thomas Snyder | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-23 | 19:00 | Loyal | 2–1 | RGV Toros | 4 | Torero Stadium | Michael Radchuk | Match Report | |
| Sat | 2022-07-23 | 19:30 | Phx Rising | 0–0 | Sac Republic | Wild Horse Pass Stadium | Brandon Stevis | Match Report | ||
| Sat | 2022-07-23 | 19:30 | Galaxy II | 2–5 | Orange County | Dignity Health Sports Park | Calin Radosav | Match Report | ||
| Sat | 2022-07-23 | 20:30 | El Paso | 0–1 | San Antonio | 6,333 | Southwest University Park | Ricardo Fierro | Match Report | |
| Sat | 2022-07-23 | 20:30 | Loudoun Utd | 1–2 | Miami FC | 1,289 | Segra Field | Austin Saini | Match Report | |
| Wed | 2022-07-27 | 19:00 | B'ham Legion | 6–1 | Loudoun Utd | Protective Stadium | Sergii Demianchuk | Match Report | ||
| Wed | 2022-07-27 | 19:00 | Roots | 0–0 | Phx Rising | 3,336 | Laney College Field | Mathew Corrigan | Match Report | |
| Wed | 2022-07-27 | 19:30 | RGV Toros | 0–0 | Hartford | 3,657 | H-E-B Park | Luis Guardia | Match Report | |
| Wed | 2022-07-27 | 19:30 | LV Lights FC | 0–2 | San Antonio | Cashman Field | Jervis Atagana | Match Report | ||
| Sat | 2022-07-30 | 19:00 | Pittsburgh | 1–0 | FC Tulsa | 5,073 | Highmark Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-07-30 | 19:00 | Indy Eleven | 1–3 | TB Rowdies | 10,074 | Michael A. Carroll Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2022-07-30 | 19:00 | Hartford | 0–1 | B'ham Legion | 4,676 | Dillon Stadium | Christian Centeno | Match Report | |
| Sat | 2022-07-30 | 19:30 | Charleston | 2–4 | Sac Republic | 2,929 | Patriots Point Soccer Complex | Abdou Ndiaye | Match Report | |
| Sat | 2022-07-30 | 19:30 | Atlanta 2 | 1–1 | LV Lights FC | 530 | Fifth Third Bank Stadium | Alejo Calume | Match Report | |
| Sat | 2022-07-30 | 19:30 | Loudoun Utd | 0–1 | Monterey Bay | 1,737 | Segra Field | Matthew Thompson | Match Report | |
| Sun | 2022-07-31 | 18:00 | NY Red Bulls II | 1–2 | New Mexico Utd | 470 | MSU Soccer Park at Pittser Field | Austin Saini | Match Report | |
| Sat | 2022-07-30 | 19:00 | Orange County | 2–3 | Loyal | 5,177 | Orange Country Great Park Championship S... | Elton Garcia | Match Report | |
| Sat | 2022-07-30 | 19:30 | Phx Rising | 4–0 | CS Switchbacks | Wild Horse Pass Stadium | Kevin Broadley | Match Report | ||
| Sat | 2022-07-30 | 20:00 | San Antonio | 1–1 | Galaxy II | 6,281 | Toyota Field | Jeremy Scheer | Match Report | |
| Sat | 2022-07-30 | 20:30 | El Paso | 0–1 | Louisville City | 6,461 | Southwest University Park | Elijio Arreguin | Match Report | |
| Wed | 2022-08-03 | 19:00 | NY Red Bulls II | 1–2 | Memphis | 382 | MSU Soccer Park at Pittser Field | Sergii Demianchuk | Match Report | |
| Wed | 2022-08-03 | 19:00 | New Mexico Utd | 1–2 | Sac Republic | 9,318 | Isotopes Park | Mathew Corrigan | Match Report | |
| Sat | 2022-08-06 | 19:00 | Indy Eleven | 0–2 | Pittsburgh | 9,839 | Michael A. Carroll Stadium | Eric Tattersall | Match Report | |
| Sat | 2022-08-06 | 19:30 | TB Rowdies | 1–0 | Detroit City | 5,104 | Al Lang Stadium | Alyssa Nichols | Match Report | |
| Sat | 2022-08-06 | 19:30 | Loudoun Utd | 2–0 | Galaxy II | 2,076 | Segra Field | Alex Beehler | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-06 | 19:00 | Loyal | 3–0 | San Antonio | 4,756 | Torero Stadium | Brandon Stevis | Match Report | |
| Sat | 2022-08-06 | 19:00 | Monterey Bay | 1–0 | El Paso | 3,328 | Cardinale Stadium | Elton Garcia | Match Report | |
| Sat | 2022-08-06 | 19:00 | New Mexico Utd | 0–3 | Miami FC | 11,024 | Isotopes Park | Brad Jensen | Match Report | |
| Sat | 2022-08-06 | 19:00 | B'ham Legion | 6–0 | Atlanta 2 | Protective Stadium | Jervis Atagana | Match Report | ||
| Sat | 2022-08-06 | 19:00 | Orange County | 3–3 | CS Switchbacks | 4,068 | Orange Country Great Park Championship S... | Ricardo Fierro | Match Report | |
| Sat | 2022-08-06 | 19:30 | Phx Rising | 0–0 | LV Lights FC | Wild Horse Pass Stadium | Greg Dopka | Match Report | ||
| Sat | 2022-08-06 | 19:30 | Memphis | 3–1 | Hartford | 3,876 | AutoZone Park | John Griggs | Match Report | |
| Sat | 2022-08-06 | 20:00 | Louisville City | 4–1 | Charleston | 11,981 | Lynn Family Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2022-08-06 | 20:00 | Sac Republic | 1–1 | RGV Toros | 8,196 | Heart Health Park | Malik Badawi | Match Report | |
| Tue | 2022-08-09 | 19:00 | NY Red Bulls II | 2–1 | Atlanta 2 | MSU Soccer Park at Pittser Field | DeShun Beard | Match Report | ||
| Wed | 2022-08-10 | 19:00 | Miami FC | 1–2 | FC Tulsa | 1,464 | Riccardo Silva Stadium | Adam Kilpatrick | Match Report | |
| Wed | 2022-08-10 | 19:00 | Loyal | 1–0 | Monterey Bay | 4,114 | Torero Stadium | Mark Allatin | Match Report | |
| Wed | 2022-08-10 | 20:00 | San Antonio | 2–1 | Loudoun Utd | 4,297 | Toyota Field | Melvin Rivas | Match Report | |
| Fri | 2022-08-12 | 19:00 | NY Red Bulls II | 1–3 | Charleston | 597 | MSU Soccer Park at Pittser Field | Elijio Arreguin | Match Report | |
| Sat | 2022-08-13 | 19:00 | Hartford | 2–1 | Indy Eleven | 4,924 | Dillon Stadium | Ben Meyer | Match Report | |
| Sat | 2022-08-13 | 19:00 | Pittsburgh | 0–2 | Memphis | 4,746 | Highmark Stadium | Brad Jensen | Match Report | |
| Fri | 2022-08-12 | 19:00 | Orange County | 2–1 | Phx Rising | 4,105 | Orange Country Great Park Championship S... | Sergii Demianchuk | Match Report | |
| Fri | 2022-08-12 | 19:00 | CS Switchbacks | 4–4 | El Paso | 7,445 | Weidner Field | Brandon Stevis | Match Report | |
| Sat | 2022-08-13 | 19:30 | Detroit City | 1–1 | Roots | 7,283 | Keyworth Stadium | John Griggs | Match Report | |
| Sat | 2022-08-13 | 19:30 | Louisville City | 1–0 | TB Rowdies | 14,673 | Lynn Family Stadium | Natalie Simon | Match Report | |
| Sat | 2022-08-13 | 19:30 | Atlanta 2 | 0–2 | Miami FC | 547 | Fifth Third Bank Stadium | Gabriele Giusti | Match Report | |
| Sat | 2022-08-13 | 19:00 | B'ham Legion | 1–0 | Loyal | Protective Stadium | Gerald Flores | Match Report | ||
| Sat | 2022-08-13 | 19:00 | Monterey Bay | 1–0 | Sac Republic | 3,618 | Cardinale Stadium | Ricardo Fierro | Match Report | |
| Sat | 2022-08-13 | 20:00 | San Antonio | 2–0 | LV Lights FC | 5,521 | Toyota Field | Adam Kilpatrick | Match Report | |
| Sun | 2022-08-14 | 17:00 | Galaxy II | 2–2 | New Mexico Utd | Dignity Health Sports Park | Kevin Broadley | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2022-08-17 | 19:00 | Orange County | 1–1 | LV Lights FC | 3,679 | Orange Country Great Park Championship S... | Melvin Rivas | Match Report | |
| Wed | 2022-08-17 | 19:00 | B'ham Legion | 1–2 | Detroit City | Protective Stadium | Elvis Osmanovic | Match Report | ||
| Wed | 2022-08-17 | 19:00 | New Mexico Utd | 0–2 | Memphis | 7,414 | Isotopes Park | José Carlos Rivero | Match Report | |
| Wed | 2022-08-17 | 20:00 | Sac Republic | 3–0 | CS Switchbacks | 8,169 | Heart Health Park | Luis Guardia | Match Report | |
| Sat | 2022-08-20 | 19:00 | Pittsburgh | 2–2 | NY Red Bulls II | 5,072 | Highmark Stadium | Gabriele Giusti | Match Report | |
| Sat | 2022-08-20 | 19:00 | Hartford | 0–2 | Miami FC | 5,500 | Dillon Stadium | Calin Radosav | Match Report | |
| Sat | 2022-08-20 | 19:30 | Loudoun Utd | 3–1 | Atlanta 2 | 1,932 | Segra Field | Alex Billeter | Match Report | |
| Sat | 2022-08-20 | 19:30 | Detroit City | 0–1 | Louisville City | 6,011 | Keyworth Stadium | Matthew Thompson | Match Report | |
| Sat | 2022-08-20 | 19:00 | CS Switchbacks | 1–0 | TB Rowdies | 6,887 | Weidner Field | Mark Allatin | Match Report | |
| Sat | 2022-08-20 | 19:00 | New Mexico Utd | 2–0 | Monterey Bay | 7,414 | Isotopes Park | Eric Tattersall | Match Report | |
| Sat | 2022-08-20 | 19:30 | Galaxy II | 1–1 | Charleston | Dignity Health Sports Park | Brandon Stevis | Match Report | ||
| Sat | 2022-08-20 | 19:30 | Memphis | 2–4 | B'ham Legion | 3,759 | AutoZone Park | Matthew Franz | Match Report | |
| Sat | 2022-08-20 | 19:30 | LV Lights FC | 2–1 | Sac Republic | Cashman Field | Elijio Arreguin | Match Report | ||
| Sat | 2022-08-20 | 19:30 | FC Tulsa | 1–0 | Indy Eleven | 5,082 | ONEOK Field | Elton Garcia | Match Report | |
| Sat | 2022-08-20 | 20:00 | San Antonio | 2–2 | RGV Toros | 6,511 | Toyota Field | Greg Dopka | Match Report | |
| Sat | 2022-08-20 | 20:30 | El Paso | 1–3 | Loyal | 6,673 | Southwest University Park | Sergii Demianchuk | Match Report | |
| Wed | 2022-08-24 | 19:00 | Loyal | 1–3 | Roots | Torero Stadium | José Carlos Rivero | Match Report | ||
| Wed | 2022-08-24 | 19:30 | FC Tulsa | 1–2 | Hartford | 3,680 | ONEOK Field | Cristian Campo | Match Report | |
| Sat | 2022-08-27 | 19:00 | Miami FC | 1–0 | Louisville City | 1,263 | Riccardo Silva Stadium | Elton Garcia | Match Report | |
| Sat | 2022-08-27 | 19:00 | Indy Eleven | 1–0 | San Antonio | 10,081 | Michael A. Carroll Stadium | Calin Radosav | Match Report | |
| Sat | 2022-08-27 | 19:30 | Atlanta 2 | 1–2 | Pittsburgh | 531 | Fifth Third Bank Stadium | Katja Koroleva | Match Report | |
| Sat | 2022-08-27 | 19:30 | TB Rowdies | 3–1 | Orange County | 6,714 | Al Lang Stadium | Matthew Thompson | Match Report | |
| Sun | 2022-08-28 | 16:00 | B'ham Legion | 3–1 | NY Red Bulls II | Protective Stadium | John Matto | Match Report | ||
| Sat | 2022-08-27 | 19:00 | CS Switchbacks | 1–0 | New Mexico Utd | 8,023 | Weidner Field | Greg Dopka | Match Report | |
| Sat | 2022-08-27 | 19:00 | Monterey Bay | 0–2 | Galaxy II | 5,077 | Cardinale Stadium | Corbyn May | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-27 | 19:30 | FC Tulsa | 2–1 | Loudoun Utd | 4,359 | ONEOK Field | Melvin Rivas | Match Report | |
| Sat | 2022-08-27 | 19:30 | LV Lights FC | 0–5 | RGV Toros | Cashman Field | Ben Meyer | Match Report | ||
| Sat | 2022-08-27 | 20:00 | Charleston | 0–3 | Detroit City | 3,168 | Patriots Point Soccer Complex | Gerald Flores | Match Report | |
| Sat | 2022-08-27 | 20:00 | Sac Republic | 1–0 | Roots | 10,916 | Heart Health Park | Matt Conger | Match Report | |
| Sat | 2022-08-27 | 20:30 | El Paso | 3–1 | Phx Rising | 6,870 | Southwest University Park | John Griggs | Match Report | |
| Wed | 2022-08-31 | 19:00 | Indy Eleven | 2–1 | Louisville City | 8,275 | Michael A. Carroll Stadium | Elvis Osmanovic | Match Report | |
| Wed | 2022-08-31 | 19:00 | Pittsburgh | 0–0 | Charleston | 2,203 | Highmark Stadium | Austin Saini | Match Report | |
| Wed | 2022-08-31 | 19:00 | NY Red Bulls II | 3–3 | Hartford | MSU Soccer Park at Pittser Field | Thomas Snyder | Match Report | ||
| Wed | 2022-08-31 | 19:00 | Memphis | 0–1 | Loudoun Utd | 3,001 | AutoZone Park | DeShun Beard | Match Report | |
| Wed | 2022-08-31 | 19:30 | Phx Rising | 2–1 | RGV Toros | Wild Horse Pass Stadium | José Carlos Rivero | Match Report | ||
| Sat | 2022-09-03 | 19:00 | Miami FC | 1–1 | B'ham Legion | 953 | Riccardo Silva Stadium | Elijio Arreguin | Match Report | |
| Fri | 2022-09-02 | 19:00 | New Mexico Utd | 1–2 | El Paso | 10,721 | Isotopes Park | Ricardo Fierro | Match Report | |
| Sat | 2022-09-03 | 19:00 | Charleston | 3–0 | NY Red Bulls II | 2,370 | Patriots Point Soccer Complex | Adorae Monroy | Match Report | |
| Sat | 2022-09-03 | 19:30 | Louisville City | 3–1 | Sac Republic | 9,292 | Lynn Family Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-09-03 | 19:30 | TB Rowdies | 6–1 | LV Lights FC | 4,485 | Al Lang Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-09-03 | 19:30 | Detroit City | 0–0 | Indy Eleven | 6,078 | Keyworth Stadium | Brandon Stevis | Match Report | |
| Sat | 2022-09-03 | 19:30 | Atlanta 2 | 2–1 | FC Tulsa | 504 | Fifth Third Bank Stadium | Alejo Calume | Match Report | |
| Sat | 2022-09-03 | 19:00 | Monterey Bay | 3–1 | Loyal | 3,208 | Cardinale Stadium | Matthew Thompson | Match Report | |
| Sat | 2022-09-03 | 19:00 | Roots | 0–2 | San Antonio | 5,093 | Laney College Field | Elvis Osmanovic | Match Report | |
| Sat | 2022-09-03 | 19:00 | Orange County | 1–1 | Memphis | 3,784 | Orange Country Great Park Championship S... | Adam Kilpatrick | Match Report | |
| Sat | 2022-09-03 | 19:00 | CS Switchbacks | 1–0 | Phx Rising | 7,623 | Weidner Field | Eric Tattersall | Match Report | |
| Sun | 2022-09-04 | 19:30 | Loudoun Utd | 1–2 | Pittsburgh | 2,020 | Segra Field | Abdou Ndiaye | Match Report | |
| Mon | 2022-09-05 | 19:30 | Galaxy II | 1–3 | Hartford | Dignity Health Sports Park | Greg Dopka | Match Report | ||
| Wed | 2022-09-07 | 19:30 | Atlanta 2 | 0–4 | Memphis | 449 | Fifth Third Bank Stadium | Ricardo Fierro | Match Report | |
| Wed | 2022-09-07 | 19:30 | Monterey Bay | 1–0 | Orange County | 2,723 | Cardinale Stadium | Brad Jensen | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2022-09-07 | 19:30 | FC Tulsa | 2–2 | Louisville City | 3,013 | ONEOK Field | Sergii Demianchuk | Match Report | |
| Wed | 2022-09-07 | 20:00 | El Paso | 0–2 | RGV Toros | 7,589 | Southwest University Park | Mark Allatin | Match Report | |
| Fri | 2022-09-09 | 19:00 | NY Red Bulls II | 1–7 | Miami FC | 794 | MSU Soccer Park at Pittser Field | Mathew Corrigan | Match Report | |
| Sat | 2022-09-10 | 19:00 | Indy Eleven | 4–3 | B'ham Legion | 10,104 | Michael A. Carroll Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-09-10 | 19:00 | Hartford | 3–2 | FC Tulsa | 5,500 | Dillon Stadium | Chris Ruska | Match Report | |
| Sat | 2022-09-10 | 19:00 | Pittsburgh | 0–0 | Louisville City | 4,233 | Highmark Stadium | Eric Tattersall | Match Report | |
| Sat | 2022-09-10 | 19:00 | Charleston | 2–1 | TB Rowdies | 2,973 | Patriots Point Soccer Complex | Luis Arroyo | Match Report | |
| Sat | 2022-09-10 | 19:00 | CS Switchbacks | 1–2 | Detroit City | 7,587 | Weidner Field | Calin Radosav | Match Report | |
| Sat | 2022-09-10 | 19:00 | Sac Republic | 4–0 | Loudoun Utd | 9,874 | Heart Health Park | Alyssa Nichols | Match Report | |
| Sat | 2022-09-10 | 19:00 | Orange County | 1–0 | Galaxy II | 5 | Orange Country Great Park Championship S... | Ben Meyer | Match Report | |
| Sat | 2022-09-10 | 19:30 | RGV Toros | 3–1 | New Mexico Utd | 4,668 | H-E-B Park | Elton Garcia | Match Report | |
| Sat | 2022-09-10 | 19:30 | Phx Rising | 0–2 | Roots | Wild Horse Pass Stadium | Brandon Stevis | Match Report | ||
| Sat | 2022-09-10 | 19:30 | San Antonio | 1–0 | Loyal | 7,019 | Toyota Field | Elijio Arreguin | Match Report | |
| Wed | 2022-09-14 | 19:00 | B'ham Legion | 2–1 | Pittsburgh | Protective Stadium | Greg Dopka | Match Report | ||
| Sat | 2022-09-17 | 19:00 | Miami FC | 2–2 | Atlanta 2 | 1,317 | Riccardo Silva Stadium | Austin Saini | Match Report | |
| Sat | 2022-09-17 | 19:00 | Hartford | 3–0 | LV Lights FC | 5,500 | Dillon Stadium | Mark Allatin | Match Report | |
| Fri | 2022-09-16 | 19:00 | Memphis | 5–0 | Charleston | 4,161 | AutoZone Park | Jervis Atagana | Match Report | |
| Sat | 2022-09-17 | 19:30 | Detroit City | 1–0 | TB Rowdies | 6,856 | Keyworth Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-09-17 | 19:30 | Louisville City | 4–2 | Loudoun Utd | 11,345 | Lynn Family Stadium | Nabil Bensalah | Match Report | |
| Sun | 2022-09-18 | 14:00 | Sac Republic | 4–0 | Orange County | 10,396 | Heart Health Park | Sergii Demianchuk | Match Report | |
| Sat | 2022-09-17 | 19:00 | Roots | 1–0 | NY Red Bulls II | 5,472 | Laney College Field | Melvin Rivas | Match Report | |
| Sat | 2022-09-17 | 19:00 | Monterey Bay | 5–0 | Indy Eleven | 3,804 | Cardinale Stadium | Gerald Flores | Match Report | |
| Sat | 2022-09-17 | 19:00 | Loyal | 3–0 | Phx Rising | Torero Stadium | Mathew Corrigan | Match Report | ||
| Sat | 2022-09-17 | 19:30 | San Antonio | 1–1 | New Mexico Utd | 6,019 | Toyota Field | Brad Jensen | Match Report | |
| Sat | 2022-09-17 | 19:30 | RGV Toros | 1–0 | CS Switchbacks | 4,534 | H-E-B Park | Luis Guardia | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-09-18 | 17:00 | Galaxy II | 2–3 | El Paso | Dignity Health Sports Park | Malik Badawi | Match Report | ||
| Wed | 2022-09-21 | 19:00 | Loudoun Utd | 3–0 | Hartford | 2,073 | Segra Field | Danielle Chesky | Match Report | |
| Wed | 2022-09-21 | 19:00 | NY Red Bulls II | 0–0 | Detroit City | 437 | MSU Soccer Park at Pittser Field | Luis Arroyo | Match Report | |
| Tue | 2022-09-20 | 19:30 | San Antonio | 1–0 | CS Switchbacks | 5,113 | Toyota Field | Elvis Osmanovic | Match Report | |
| Wed | 2022-09-21 | 19:30 | Monterey Bay | 3–3 | Phx Rising | 3,529 | Cardinale Stadium | Malik Badawi | Match Report | |
| Fri | 2022-09-23 | 19:00 | Charleston | 0–3 | RGV Toros | 3,159 | Patriots Point Soccer Complex | Alejo Calume | Match Report | |
| Fri | 2022-09-23 | 19:30 | TB Rowdies | 1–1 | B'ham Legion | 5,150 | Al Lang Stadium | Adam Kilpatrick | Match Report | |
| Sat | 2022-09-24 | 19:00 | Miami FC | 0–0 | Monterey Bay | 1,019 | Riccardo Silva Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-09-24 | 19:00 | Pittsburgh | 1–1 | Orange County | 4,639 | Highmark Stadium | Elton Garcia | Match Report | |
| Sat | 2022-09-24 | 19:30 | Detroit City | 2–2 | FC Tulsa | 6,531 | Keyworth Stadium | Greg Dopka | Match Report | |
| Fri | 2022-09-23 | 20:00 | Louisville City | 1–2 | Memphis | 10,808 | Lynn Family Stadium | Gabriele Giusti | Match Report | |
| Sun | 2022-09-25 | 17:00 | Indy Eleven | 1–0 | Loudoun Utd | 8,575 | Michael A. Carroll Stadium | Austin Saini | Match Report | |
| Sat | 2022-09-24 | 18:00 | CS Switchbacks | 1–1 | Roots | 8,023 | Weidner Field | John Griggs | Match Report | |
| Sat | 2022-09-24 | 19:00 | LV Lights FC | 1–2 | Loyal | Cashman Field | Elvis Osmanovic | Match Report | ||
| Sat | 2022-09-24 | 19:30 | San Antonio | 1–0 | Sac Republic | 6,205 | Toyota Field | Mathew Corrigan | Match Report | |
| Tue | 2022-09-27 | 19:00 | LV Lights FC | 4–0 | Monterey Bay | Cashman Field | John Griggs | Match Report | ||
| Wed | 2022-09-28 | 19:30 | Atlanta 2 | 0–1 | Indy Eleven | 693 | Fifth Third Bank Stadium | Alyssa Nichols | Match Report | |
| Wed | 2022-09-28 | 19:00 | Sac Republic | 0–1 | Phx Rising | 9,110 | Heart Health Park | Matt Conger | Match Report | |
| Sat | 2022-10-01 | 18:30 | Loudoun Utd | 0–4 | Detroit City | 2,496 | Segra Field | Alyssa Nichols | Match Report | |
| Sat | 2022-10-01 | 19:00 | Hartford | 6–3 | Charleston | 5,500 | Dillon Stadium | Alex Billeter | Match Report | |
| Sat | 2022-10-01 | 19:00 | Indy Eleven | 2–4 | FC Tulsa | 9,633 | Michael A. Carroll Stadium | Danielle Chesky | Match Report | |
| Sat | 2022-10-01 | 19:00 | Miami FC | 1–0 | Memphis | 1,492 | Riccardo Silva Stadium | Elvis Osmanovic | Match Report | |
| Fri | 2022-09-30 | 19:00 | LV Lights FC | 0–0 | New Mexico Utd | Cashman Field | Malik Badawi | Match Report | ||
| Sat | 2022-10-01 | 19:00 | Pittsburgh | 0–1 | San Antonio | 3,045 | Highmark Stadium | Thomas Snyder | Match Report | |
| Sat | 2022-10-01 | 19:00 | Orange County | 2–2 | Loyal | 5,425 | Orange Country Great Park Championship S... | Matthew Thompson | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-10-01 | 19:00 | Roots | 2–1 | B'ham Legion | 5,509 | Laney College Field | Mathew Corrigan | Match Report | |
| Sat | 2022-10-01 | 19:30 | Phx Rising | 5–1 | NY Red Bulls II | 5,425 | Wild Horse Pass Stadium | Greg Dopka | Match Report | |
| Sat | 2022-10-01 | 19:30 | RGV Toros | 0–1 | Louisville City | 4,748 | H-E-B Park | Ricardo Fierro | Match Report | |
| Sun | 2022-10-02 | 17:00 | Galaxy II | 2–0 | Sac Republic | Dignity Health Sports Park | Brad Jensen | Match Report | ||
| Sun | 2022-10-02 | 19:00 | Monterey Bay | 1–2 | TB Rowdies | 5,705 | Cardinale Stadium | Melvin Rivas | Match Report | |
| Wed | 2022-10-05 | 19:30 | Louisville City | 2–1 | Detroit City | 9,524 | Lynn Family Stadium | John Griggs | Match Report | |
| Wed | 2022-10-05 | 19:00 | Memphis | 2–2 | RGV Toros | 3,072 | AutoZone Park | Gabriele Giusti | Match Report | |
| Wed | 2022-10-05 | 20:00 | El Paso | 1–4 | CS Switchbacks | Southwest University Park | Gerald Flores | Match Report | ||
| Sat | 2022-10-08 | 19:00 | Indy Eleven | 4–1 | Charleston | 10,272 | Michael A. Carroll Stadium | Cristian Campo | Match Report | |
| Sat | 2022-10-08 | 19:00 | Hartford | 1–3 | Roots | 5,500 | Dillon Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2022-10-08 | 19:30 | TB Rowdies | 8–0 | Loudoun Utd | 5,147 | Al Lang Stadium | Eric Tattersall | Match Report | |
| Sun | 2022-10-09 | 14:00 | Sac Republic | 1–1 | Pittsburgh | 11,569 | Heart Health Park | Mark Allatin | Match Report | |
| Sun | 2022-10-09 | 15:00 | Memphis | 2–1 | NY Red Bulls II | 4,408 | AutoZone Park | Thomas Snyder | Match Report | |
| Sun | 2022-10-09 | 15:00 | Loyal | 3–3 | New Mexico Utd | 5,621 | Torero Stadium | Kevin Broadley | Match Report | |
| Sun | 2022-10-09 | 16:00 | B'ham Legion | 1–2 | San Antonio | Protective Stadium | Sergii Demianchuk | Match Report | ||
| Sat | 2022-10-08 | 19:00 | LV Lights FC | 3–2 | Miami FC | Cashman Field | Elton Garcia | Match Report | ||
| Sat | 2022-10-08 | 19:30 | RGV Toros | 2–1 | Phx Rising | 5,333 | H-E-B Park | Elijio Arreguin | Match Report | |
| Sat | 2022-10-08 | 19:30 | Galaxy II | 1–3 | Atlanta 2 | Dignity Health Sports Park | Adam Kilpatrick | Match Report | ||
| Sat | 2022-10-08 | 20:30 | El Paso | 2–1 | Orange County | Southwest University Park | Calin Radosav | Match Report | ||
| Wed | 2022-10-12 | 19:30 | TB Rowdies | 3–1 | El Paso | 3,454 | Al Lang Stadium | Sergii Demianchuk | Match Report | |
| Wed | 2022-10-12 | 19:00 | New Mexico Utd | 3–2 | Galaxy II | 10,426 | Isotopes Park | Ricardo Fierro | Match Report | |
| Wed | 2022-10-12 | 19:00 | B'ham Legion | 3–1 | Indy Eleven | Protective Stadium | John Griggs | Match Report | ||
| Wed | 2022-10-12 | 19:30 | FC Tulsa | 2–0 | Monterey Bay | 5,135 | ONEOK Field | Natalie Simon | Match Report | |
| Sat | 2022-10-15 | 16:00 | Detroit City | 0–1 | Miami FC | 7,537 | Keyworth Stadium | Luis Guardia | Match Report | |
| Sat | 2022-10-15 | 17:00 | Charleston | 1–1 | Loudoun Utd | 4,325 | Patriots Point Soccer Complex | Matthew Franz | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-10-15 | 19:00 | Pittsburgh | 3–1 | Roots | 5,182 | Highmark Stadium | Matthew Thompson | Match Report | |
| Sat | 2022-10-15 | 19:30 | Louisville City | 2–1 | Hartford | 12,096 | Lynn Family Stadium | Calin Radosav | Match Report | |
| Sat | 2022-10-15 | 19:30 | TB Rowdies | 1–0 | NY Red Bulls II | 6,293 | Al Lang Stadium | Jeremy Scheer | Match Report | |
| Sat | 2022-10-15 | 19:00 | New Mexico Utd | 2–0 | CS Switchbacks | 14,519 | Isotopes Park | Natalie Simon | Match Report | |
| Sat | 2022-10-15 | 19:00 | Sac Republic | 4–0 | Loyal | 11,569 | Heart Health Park | John Griggs | Match Report | |
| Sat | 2022-10-15 | 19:30 | Phx Rising | 3–1 | Atlanta 2 | Wild Horse Pass Stadium | Nabil Bensalah | Match Report | ||
| Sat | 2022-10-15 | 19:30 | RGV Toros | 4–1 | Monterey Bay | 5,139 | H-E-B Park | Brad Jensen | Match Report | |
| Sat | 2022-10-15 | 19:30 | San Antonio | 2–2 | Orange County | 8,015 | Toyota Field | Danielle Chesky | Match Report | |
| Sat | 2022-10-15 | 19:30 | FC Tulsa | 0–3 | Memphis | 5,392 | ONEOK Field | Malik Badawi | Match Report | |
| Sat | 2022-10-15 | 19:30 | Galaxy II | 1–1 | LV Lights FC | Dignity Health Sports Park | Greg Dopka | Match Report |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
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