Scores & Fixtures 2021 USL Championship
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2021-04-24 | 19:30 | Louisville City | 2–0 | Atlanta 2 | 7,652 | Lynn Family Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-04-24 | 19:30 | OKC Energy | 1–3 | FC Tulsa | 3,380 | Taft Stadium | Ismir Pekmic | Match Report | |
| Fri | 2021-04-30 | 19:00 | NY Red Bulls II | 2–3 | Hartford | Red Bull Arena | Joshua Encarnacion | Match Report | ||
| Sat | 2021-05-01 | 18:30 | B'ham Legion | 0–1 | Indy Eleven | BBVA Compass Field | Greg Dopka | Match Report | ||
| Fri | 2021-04-30 | 19:00 | Phx Rising | 4–1 | Loyal | Casino Arizona Field | Jon Freemon | Match Report | ||
| Sat | 2021-05-01 | 19:30 | TB Rowdies | 3–0 | Charlotte Ind'ence | 1,870 | Al Lang Stadium | Tori Penso | Match Report | |
| Fri | 2021-04-30 | 19:30 | Galaxy II | 0–1 | Sac Republic | Dignity Health Sports Park | Michael Radchuk | Match Report | ||
| Sat | 2021-05-01 | 19:00 | FC Tulsa | 2–0 | Sporting KC II | 4,241 | ONEOK Field | Elijio Arreguin | Match Report | |
| Sun | 2021-05-02 | 19:30 | Miami FC | 2–1 | Loudoun Utd | Riccardo Silva Stadium | Natalie Simon | Match Report | ||
| Sat | 2021-05-01 | 19:30 | San Antonio | 3–0 | CS Switchbacks | 3,768 | Toyota Field | Matthew Thompson | Match Report | |
| Sat | 2021-05-01 | 19:30 | RGV Toros | 1–0 | New Mexico Utd | 2,567 | H-E-B Park | Elton Garcia | Match Report | |
| Sat | 2021-05-01 | 19:30 | OKC Energy | 0–1 | Atlanta 2 | 2,299 | Taft Stadium | Brandon Stevis | Match Report | |
| Wed | 2021-05-05 | 19:30 | Galaxy II | 5–0 | LV Lights FC | Dignity Health Sports Park | Mark Allatin | Match Report | ||
| Fri | 2021-05-07 | 19:00 | NY Red Bulls II | 1–1 | Charleston | MSU Soccer Park at Pittser Field | Jeremy Scheer | Match Report | ||
| Thu | 2021-05-06 | 19:00 | RGV Toros | 1–0 | Loyal | 2,195 | H-E-B Park | Mathew Corrigan | Match Report | |
| Sat | 2021-05-08 | 19:00 | Indy Eleven | 0–2 | FC Tulsa | Michael A. Carroll Stadium | Lukasz Szpala | Match Report | ||
| Fri | 2021-05-07 | 19:00 | Sporting KC II | 1–1 | OKC Energy | Children's Mercy Park | Jon Freemon | Match Report | ||
| Sat | 2021-05-08 | 19:30 | Miami FC | 0–1 | Hartford | Riccardo Silva Stadium | Matthew Thompson | Match Report | ||
| Sat | 2021-05-08 | 19:30 | TB Rowdies | 3–0 | Pittsburgh | 1,978 | Al Lang Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2021-05-08 | 19:30 | Louisville City | 1–1 | B'ham Legion | 7,652 | Lynn Family Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2021-05-08 | 19:30 | San Antonio | 2–2 | Monarchs | 3,735 | Toyota Field | Michael Radchuk | Match Report | |
| Sat | 2021-05-08 | 19:30 | Phx Rising | 3–0 | Roots | Casino Arizona Field | Elton Garcia | Match Report | ||
| Sat | 2021-05-08 | 20:30 | El Paso | 1–1 | New Mexico Utd | 5,740 | Southwest University Park | Ismir Pekmic | Match Report | |
| Sun | 2021-05-09 | 17:00 | Galaxy II | 1–1 | Tacoma | Dignity Health Sports Park | Ricardo Fierro | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-05-12 | 19:30 | Sac Republic | 3–1 | LV Lights FC | Papa Murphy’s Park | Mathew Corrigan | Match Report | ||
| Thu | 2021-05-13 | 19:00 | Tacoma | 3–1 | Loyal | 1,222 | Cheney Stadium | Chris Ruska | Match Report | |
| Fri | 2021-05-14 | 19:00 | Charleston | 0–3 | Charlotte Ind'ence | 1,681 | Patriots Point Soccer Complex | Izlen Peksenar | Match Report | |
| Fri | 2021-05-14 | 19:00 | NY Red Bulls II | 0–1 | Miami FC | 510 | MSU Soccer Park at Pittser Field | Sergii Demianchuk | Match Report | |
| Sat | 2021-05-15 | 15:30 | B'ham Legion | 1–0 | Memphis | 10,177 | BBVA Compass Field | Kyle Johnston | Match Report | |
| Fri | 2021-05-14 | 19:00 | Monarchs | 0–2 | Galaxy II | 1,715 | Zions Bank Stadium | Elijio Arreguin | Match Report | |
| Fri | 2021-05-14 | 19:00 | Sporting KC II | 0–4 | CS Switchbacks | Children's Mercy Park | Greg Dopka | Match Report | ||
| Sat | 2021-05-15 | 19:00 | Hartford | 1–1 | Pittsburgh | 2,750 | Dillon Stadium | Lukasz Szpala | Match Report | |
| Sun | 2021-05-16 | 12:00 | Tacoma | 1–0 | Orange County | 1,214 | Cheney Stadium | Mark Allatin | Match Report | |
| Sun | 2021-05-16 | 17:00 | OKC Energy | 2–2 | Atlanta 2 | 1,732 | Taft Stadium | John Griggs | Match Report | |
| Sat | 2021-05-15 | 19:30 | New Mexico Utd | 3–1 | Bold | 8,647 | Isotopes Park | Michael Radchuk | Match Report | |
| Sat | 2021-05-15 | 20:00 | TB Rowdies | 2–1 | Phx Rising | 2,355 | Al Lang Stadium | Ismir Pekmic | Match Report | |
| Sun | 2021-05-16 | 19:30 | RGV Toros | 2–1 | San Antonio | 2,610 | H-E-B Park | Melvin Rivas | Match Report | |
| Tue | 2021-05-18 | 19:00 | Loudoun Utd | 1–2 | NY Red Bulls II | 710 | Segra Field | Danielle Chesky | Match Report | |
| Wed | 2021-05-19 | 19:30 | Atlanta 2 | 5–0 | FC Tulsa | 650 | Fifth Third Bank Stadium | Alyssa Nichols | Match Report | |
| Wed | 2021-05-19 | 19:30 | Galaxy II | 1–1 | Sporting KC II | Dignity Health Sports Park | Brad Jensen | Match Report | ||
| Sat | 2021-05-22 | 19:00 | Indy Eleven | 2–0 | Sporting KC II | 3,999 | Michael A. Carroll Stadium | Mathew Corrigan | Match Report | |
| Fri | 2021-05-21 | 19:00 | CS Switchbacks | 1–3 | New Mexico Utd | 5,600 | Weidner Field | Elijio Arreguin | Match Report | |
| Fri | 2021-05-21 | 19:00 | Monarchs | 1–1 | Bold | 1,409 | Zions Bank Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2021-05-22 | 19:00 | Pittsburgh | 0–1 | Charlotte Ind'ence | Highmark Stadium | Thomas Snyder | Match Report | ||
| Sat | 2021-05-22 | 19:30 | TB Rowdies | 2–1 | Miami FC | 2,518 | Al Lang Stadium | Gabriele Giusti | Match Report | |
| Sat | 2021-05-22 | 19:30 | Louisville City | 2–1 | Loyal | 7,652 | Lynn Family Stadium | Ismir Pekmic | Match Report | |
| Sun | 2021-05-23 | 14:00 | Charleston | 2–2 | NY Red Bulls II | 1,550 | Patriots Point Soccer Complex | Jonathan Bilinski | Match Report | |
| Sun | 2021-05-23 | 15:30 | Atlanta 2 | 2–2 | Memphis | 643 | Fifth Third Bank Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2021-05-22 | 19:00 | Orange County | 1–0 | Sac Republic | 5,740 | Orange Country Great Park Championship S... | Jon Freemon | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-05-22 | 19:30 | Phx Rising | 5–1 | LV Lights FC | Casino Arizona Field | Michael Radchuk | Match Report | ||
| Sat | 2021-05-22 | 19:30 | San Antonio | 2–1 | B'ham Legion | 3,845 | Toyota Field | Sergii Demianchuk | Match Report | |
| Sat | 2021-05-22 | 20:30 | El Paso | 1–0 | RGV Toros | 6,325 | Southwest University Park | Lukasz Szpala | Match Report | |
| Sun | 2021-05-23 | 17:00 | Galaxy II | 2–3 | Roots | Dignity Health Sports Park | Brandon Stevis | Match Report | ||
| Wed | 2021-05-26 | 19:00 | B'ham Legion | 1–0 | OKC Energy | BBVA Compass Field | Matthew Thompson | Match Report | ||
| Wed | 2021-05-26 | 20:00 | Bold | 2–0 | Monarchs | 1,347 | Bold Stadium | Melvin Rivas | Match Report | |
| Fri | 2021-05-28 | 19:00 | NY Red Bulls II | 0–3 | Pittsburgh | 369 | MSU Soccer Park at Pittser Field | Joshua Encarnacion | Match Report | |
| Sat | 2021-05-29 | 19:30 | Louisville City | 1–2 | Indy Eleven | 10,731 | Lynn Family Stadium | Elijio Arreguin | Match Report | |
| Sat | 2021-05-29 | 19:30 | Miami FC | 2–1 | Charlotte Ind'ence | Riccardo Silva Stadium | Jonathan Bilinski | Match Report | ||
| Sun | 2021-05-30 | 15:30 | Atlanta 2 | 0–1 | B'ham Legion | Fifth Third Bank Stadium | Thomas Snyder | Match Report | ||
| Sun | 2021-05-30 | 16:00 | Sporting KC II | 0–0 | El Paso | Children's Mercy Park | Elvis Osmanovic | Match Report | ||
| Sat | 2021-05-29 | 19:00 | Orange County | 3–4 | Galaxy II | Orange Country Great Park Championship S... | Joseph Salinas | Match Report | ||
| Sat | 2021-05-29 | 19:30 | New Mexico Utd | 0–1 | Loudoun Utd | 8,801 | Isotopes Park | Chris Ruska | Match Report | |
| Sat | 2021-05-29 | 19:30 | OKC Energy | 0–0 | Memphis | 2,102 | Taft Stadium | Mathew Corrigan | Match Report | |
| Sat | 2021-05-29 | 19:30 | Loyal | 2–1 | LV Lights FC | 2,000 | Torero Stadium | Elton Garcia | Match Report | |
| Sat | 2021-05-29 | 19:30 | Sac Republic | 0–1 | Phx Rising | 2,513 | Papa Murphy’s Park | Brandon Stevis | Match Report | |
| Sat | 2021-05-29 | 19:30 | San Antonio | 1–1 | RGV Toros | 3,852 | Toyota Field | Jon Freemon | Match Report | |
| Wed | 2021-06-02 | 19:00 | NY Red Bulls II | 0–1 | TB Rowdies | 543 | MSU Soccer Park at Pittser Field | Luis Arroyo | Match Report | |
| Wed | 2021-06-02 | 19:00 | Loudoun Utd | 2–3 | Pittsburgh | 817 | Segra Field | John Griggs | Match Report | |
| Wed | 2021-06-02 | 19:00 | Indy Eleven | 1–1 | OKC Energy | 3,999 | Michael A. Carroll Stadium | Calin Radosav | Match Report | |
| Wed | 2021-06-02 | 19:00 | Sporting KC II | 4–1 | FC Tulsa | Children's Mercy Park | Matthew Thompson | Match Report | ||
| Wed | 2021-06-02 | 20:00 | Sac Republic | 3–3 | Roots | 2,513 | Papa Murphy’s Park | Nicholas Marin | Match Report | |
| Thu | 2021-06-03 | 20:00 | Bold | 0–1 | El Paso | 791 | Bold Stadium | Mark Allatin | Match Report | |
| Sat | 2021-06-05 | 19:00 | Indy Eleven | 1–2 | Memphis | 4,999 | Michael A. Carroll Stadium | Matthew Thompson | Match Report | |
| Sat | 2021-06-05 | 19:00 | Hartford | 7–0 | NY Red Bulls II | 5,023 | Dillon Stadium | Thomas Snyder | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-06-05 | 19:00 | Charlotte Ind'ence | 1–0 | TB Rowdies | 2,380 | American Legion Memorial Stadium | Greg Dopka | Match Report | |
| Fri | 2021-06-04 | 20:00 | Monarchs | 0–1 | New Mexico Utd | 1,088 | Zions Bank Stadium | Lukasz Szpala | Match Report | |
| Sun | 2021-06-06 | 16:00 | B'ham Legion | 2–1 | FC Tulsa | BBVA Compass Field | Elvis Osmanovic | Match Report | ||
| Sun | 2021-06-06 | 18:00 | Pittsburgh | 0–1 | Bold | 2,568 | Highmark Stadium | Elton Garcia | Match Report | |
| Sat | 2021-06-05 | 18:00 | CS Switchbacks | 1–1 | San Antonio | 5,531 | Weidner Field | Brandon Stevis | Match Report | |
| Sun | 2021-06-06 | 18:30 | Miami FC | 2–4 | RGV Toros | Riccardo Silva Stadium | Jeremy Scheer | Match Report | ||
| Sun | 2021-06-06 | 19:30 | Atlanta 2 | 1–0 | Louisville City | 835 | Fifth Third Bank Stadium | Natalie Simon | Match Report | |
| Sat | 2021-06-05 | 19:30 | Phx Rising | 2–2 | Loyal | 2,513 | Casino Arizona Field | Elijio Arreguin | Match Report | |
| Sat | 2021-06-05 | 19:30 | LV Lights FC | 2–0 | Tacoma | Cashman Field | Joseph Salinas | Match Report | ||
| Sat | 2021-06-05 | 20:00 | Sac Republic | 1–3 | Orange County | 2,513 | Papa Murphy’s Park | Ismir Pekmic | Match Report | |
| Tue | 2021-06-08 | 19:00 | Loudoun Utd | 0–1 | Charleston | 1,126 | Segra Field | Nabil Bensalah | Match Report | |
| Wed | 2021-06-09 | 19:30 | Atlanta 2 | 2–2 | Sporting KC II | 1,421 | Fifth Third Bank Stadium | Natalie Simon | Match Report | |
| Wed | 2021-06-09 | 19:00 | Orange County | 1–1 | Loyal | 2,042 | Orange Country Great Park Championship S... | Michael Radchuk | Match Report | |
| Wed | 2021-06-09 | 20:00 | El Paso | 2–0 | Indy Eleven | 5,189 | Southwest University Park | Jon Freemon | Match Report | |
| Wed | 2021-06-09 | 20:00 | Monarchs | 2–0 | Sac Republic | 1,019 | Zions Bank Stadium | Brad Jensen | Match Report | |
| Fri | 2021-06-11 | 19:30 | TB Rowdies | 2–1 | Loudoun Utd | 4,332 | Al Lang Stadium | Jonathan Bilinski | Match Report | |
| Sat | 2021-06-12 | 19:00 | Pittsburgh | 1–1 | Miami FC | 3,115 | Highmark Stadium | Brad Jensen | Match Report | |
| Fri | 2021-06-11 | 19:30 | LV Lights FC | 1–1 | San Antonio | Cashman Field | Lukasz Szpala | Match Report | ||
| Sat | 2021-06-12 | 19:30 | Louisville City | 3–0 | Memphis | 12,115 | Lynn Family Stadium | Greg Dopka | Match Report | |
| Sat | 2021-06-12 | 19:00 | Orange County | 1–0 | Roots | 2,082 | Orange Country Great Park Championship S... | Mathew Corrigan | Match Report | |
| Sun | 2021-06-13 | 19:00 | Charlotte Ind'ence | 3–2 | Hartford | 533 | American Legion Memorial Stadium | Jon Freemon | Match Report | |
| Sat | 2021-06-12 | 19:00 | RGV Toros | 1–0 | Monarchs | 2,583 | H-E-B Park | Matthew Thompson | Match Report | |
| Sat | 2021-06-12 | 19:30 | Loyal | 2–1 | Galaxy II | 2,033 | Torero Stadium | Ricardo Fierro | Match Report | |
| Sat | 2021-06-12 | 19:30 | OKC Energy | 1–2 | B'ham Legion | 2,049 | Taft Stadium | Mark Allatin | Match Report | |
| Sat | 2021-06-12 | 19:30 | Phx Rising | 3–0 | Tacoma | 7,316 | Casino Arizona Field | Malik Badawi | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-06-12 | 19:30 | New Mexico Utd | 0–0 | Bold | 9,288 | Isotopes Park | Sergii Demianchuk | Match Report | |
| Sat | 2021-06-12 | 20:30 | El Paso | 1–1 | CS Switchbacks | 6,589 | Southwest University Park | Elijio Arreguin | Match Report | |
| Wed | 2021-06-16 | 19:30 | Louisville City | 2–0 | B'ham Legion | 9,576 | Lynn Family Stadium | Lukasz Szpala | Match Report | |
| Tue | 2021-06-15 | 20:00 | Indy Eleven | 0–1 | Pittsburgh | 4,999 | Michael A. Carroll Stadium | Chris Ruska | Match Report | |
| Wed | 2021-06-16 | 19:00 | RGV Toros | 1–2 | Bold | 2,572 | H-E-B Park | Ismir Pekmic | Match Report | |
| Wed | 2021-06-16 | 19:00 | CS Switchbacks | 4–2 | Tacoma | 5,164 | Weidner Field | John Griggs | Match Report | |
| Wed | 2021-06-16 | 19:00 | FC Tulsa | 4–3 | Sporting KC II | 3,690 | ONEOK Field | Matthew Franz | Match Report | |
| Wed | 2021-06-16 | 19:30 | Memphis | 1–0 | Atlanta 2 | 5,083 | AutoZone Park | Jeremy Scheer | Match Report | |
| Wed | 2021-06-16 | 19:30 | New Mexico Utd | 2–0 | San Antonio | 6,260 | Isotopes Park | Elton Garcia | Match Report | |
| Wed | 2021-06-16 | 19:30 | Galaxy II | 3–4 | LV Lights FC | Dignity Health Sports Park | William Hoffman | Match Report | ||
| Wed | 2021-06-16 | 20:00 | NY Red Bulls II | 3–1 | Charlotte Ind'ence | 489 | MSU Soccer Park at Pittser Field | Natalie Simon | Match Report | |
| Fri | 2021-06-18 | 19:00 | Charleston | 2–1 | Miami FC | 2,085 | Patriots Point Soccer Complex | William Steffen | Match Report | |
| Sat | 2021-06-19 | 19:00 | Hartford | 2–1 | Loudoun Utd | 4,019 | Dillon Stadium | Christian Centeno | Match Report | |
| Sat | 2021-06-19 | 19:30 | TB Rowdies | 1–2 | Pittsburgh | 4,627 | Al Lang Stadium | Sergii Demianchuk | Match Report | |
| Fri | 2021-06-18 | 20:00 | Monarchs | 1–2 | El Paso | 800 | Zions Bank Stadium | Mathew Corrigan | Match Report | |
| Sun | 2021-06-20 | 16:00 | Sporting KC II | 1–2 | Indy Eleven | Children's Mercy Park | Adam Kilpatrick | Match Report | ||
| Sat | 2021-06-19 | 19:00 | FC Tulsa | 2–3 | Louisville City | 3,976 | ONEOK Field | Brandon Stevis | Match Report | |
| Sat | 2021-06-19 | 19:30 | LV Lights FC | 1–3 | Orange County | Cashman Field | Luis Guardia | Match Report | ||
| Sat | 2021-06-19 | 19:30 | San Antonio | 1–1 | RGV Toros | 3,920 | Toyota Field | Elijio Arreguin | Match Report | |
| Sat | 2021-06-19 | 19:30 | Loyal | 2–1 | Phx Rising | Torero Stadium | Mark Allatin | Match Report | ||
| Sat | 2021-06-19 | 19:30 | Memphis | 0–1 | OKC Energy | 5,265 | AutoZone Park | Elvis Osmanovic | Match Report | |
| Wed | 2021-06-23 | 19:00 | Charlotte Ind'ence | 3–0 | Charleston | 1,250 | American Legion Memorial Stadium | Matthew Franz | Match Report | |
| Tue | 2021-06-22 | 20:00 | Bold | 2–3 | CS Switchbacks | 1,248 | Bold Stadium | Joshua Encarnacion | Match Report | |
| Wed | 2021-06-23 | 19:00 | Tacoma | 1–1 | Monarchs | 857 | Cheney Stadium | Ricardo Fierro | Match Report | |
| Wed | 2021-06-23 | 19:30 | Galaxy II | 1–1 | Orange County | Dignity Health Sports Park | Melvin Rivas | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-06-23 | 19:30 | OKC Energy | 1–0 | Sporting KC II | 1,721 | Taft Stadium | Greg Dopka | Match Report | |
| Wed | 2021-06-23 | 20:00 | Miami FC | 0–1 | B'ham Legion | Riccardo Silva Stadium | John Griggs | Match Report | ||
| Fri | 2021-06-25 | 19:00 | Pittsburgh | 2–1 | NY Red Bulls II | 3,237 | Highmark Stadium | Kevin Fikar | Match Report | |
| Sat | 2021-06-26 | 19:00 | Hartford | 0–1 | TB Rowdies | 4,966 | Dillon Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2021-06-26 | 19:00 | Charleston | 3–0 | Loudoun Utd | 2,694 | Patriots Point Soccer Complex | Adam Kilpatrick | Match Report | |
| Fri | 2021-06-25 | 19:00 | CS Switchbacks | 3–1 | New Mexico Utd | 6,481 | Weidner Field | Mathew Corrigan | Match Report | |
| Sat | 2021-06-26 | 19:30 | Louisville City | 3–3 | Indy Eleven | 10,927 | Lynn Family Stadium | Gabriele Giusti | Match Report | |
| Sat | 2021-06-26 | 19:30 | Miami FC | 2–1 | Charlotte Ind'ence | Riccardo Silva Stadium | Sergii Demianchuk | Match Report | ||
| Fri | 2021-06-25 | 19:30 | RGV Toros | 1–2 | FC Tulsa | 2,955 | H-E-B Park | Mark Allatin | Match Report | |
| Fri | 2021-06-25 | 19:30 | LV Lights FC | 1–2 | Loyal | Cashman Field | Brad Jensen | Match Report | ||
| Sun | 2021-06-27 | 13:30 | Tacoma | 2–0 | Galaxy II | 924 | Cheney Stadium | Luis Guardia | Match Report | |
| Sat | 2021-06-26 | 19:30 | Roots | 0–0 | Bold | Las Positas College Turf Field | Joseph Salinas | Match Report | ||
| Sat | 2021-06-26 | 19:30 | Memphis | 2–3 | Sporting KC II | 4,875 | AutoZone Park | Jonathan Bilinski | Match Report | |
| Sun | 2021-06-27 | 19:30 | Atlanta 2 | 1–2 | OKC Energy | 755 | Fifth Third Bank Stadium | Jervis Atagana | Match Report | |
| Sat | 2021-06-26 | 20:00 | Monarchs | 1–1 | San Antonio | 1,158 | Zions Bank Stadium | Katja Koroleva | Match Report | |
| Sat | 2021-06-26 | 20:00 | Sac Republic | 1–2 | Phx Rising | 7,112 | Papa Murphy’s Park | Matthew Thompson | Match Report | |
| Wed | 2021-06-30 | 19:00 | Loudoun Utd | 2–1 | Pittsburgh | 984 | Segra Field | Matthew Franz | Match Report | |
| Tue | 2021-06-29 | 19:30 | Loyal | 1–0 | Roots | 3,152 | Torero Stadium | Elvis Osmanovic | Match Report | |
| Wed | 2021-06-30 | 19:00 | RGV Toros | 3–2 | El Paso | 2,445 | H-E-B Park | Brandon Stevis | Match Report | |
| Wed | 2021-06-30 | 20:00 | Monarchs | 3–2 | New Mexico Utd | 965 | Zions Bank Stadium | Calin Radosav | Match Report | |
| Thu | 2021-07-01 | 19:00 | CS Switchbacks | 0–2 | Orange County | 5,298 | Weidner Field | Brad Jensen | Match Report | |
| Fri | 2021-07-02 | 19:00 | NY Red Bulls II | 1–1 | Miami FC | 518 | MSU Soccer Park at Pittser Field | Adam Kilpatrick | Match Report | |
| Fri | 2021-07-02 | 19:30 | TB Rowdies | 1–0 | Charleston | 4,326 | Al Lang Stadium | Kyle Johnston | Match Report | |
| Sat | 2021-07-03 | 16:00 | Loyal | 1–1 | Sac Republic | 4,272 | Torero Stadium | Brandon Stevis | Match Report | |
| Fri | 2021-07-02 | 19:00 | Sporting KC II | 2–4 | Louisville City | Children's Mercy Park | Kevin Fikar | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-07-03 | 19:00 | Pittsburgh | 1–0 | Charlotte Ind'ence | 3,221 | Highmark Stadium | Jonathan Bilinski | Match Report | |
| Sat | 2021-07-03 | 19:00 | Indy Eleven | 0–1 | B'ham Legion | 6,999 | Michael A. Carroll Stadium | Jervis Atagana | Match Report | |
| Fri | 2021-07-02 | 19:30 | OKC Energy | 0–0 | FC Tulsa | 2,673 | Taft Stadium | Matthew Thompson | Match Report | |
| Sat | 2021-07-03 | 19:30 | Atlanta 2 | 2–2 | Memphis | 706 | Fifth Third Bank Stadium | Joshua Belk | Match Report | |
| Sun | 2021-07-04 | 17:00 | Loudoun Utd | 0–2 | Hartford | 693 | Segra Field | Jeremy Scheer | Match Report | |
| Sat | 2021-07-03 | 19:30 | LV Lights FC | 1–0 | Tacoma | Cashman Field | Gerald Flores | Match Report | ||
| Sat | 2021-07-03 | 19:30 | San Antonio | 0–1 | Bold | 6,243 | Toyota Field | Matthew Franz | Match Report | |
| Sat | 2021-07-03 | 19:30 | Phx Rising | 3–0 | Galaxy II | 8,815 | Casino Arizona Field | Joshua Encarnacion | Match Report | |
| Sat | 2021-07-03 | 20:30 | El Paso | 2–1 | New Mexico Utd | 8,138 | Southwest University Park | Elvis Osmanovic | Match Report | |
| Sun | 2021-07-04 | 18:30 | CS Switchbacks | 3–1 | Monarchs | 8,023 | Weidner Field | Héctor Hernández | Match Report | |
| Wed | 2021-07-07 | 16:00 | Charleston | 1–1 | Pittsburgh | Patriots Point Soccer Complex | Greg Dopka | Match Report | ||
| Wed | 2021-07-07 | 19:00 | Charlotte Ind'ence | 2–3 | NY Red Bulls II | 4,231 | American Legion Memorial Stadium | John Griggs | Match Report | |
| Tue | 2021-07-06 | 19:00 | Orange County | 0–0 | Tacoma | 2,454 | Orange Country Great Park Championship S... | Chris Ruska | Match Report | |
| Wed | 2021-07-07 | 19:30 | Miami FC | 2–1 | TB Rowdies | FIU Soccer Stadium | Thomas Snyder | Match Report | ||
| Wed | 2021-07-07 | 19:30 | Atlanta 2 | 1–1 | Indy Eleven | 638 | Fifth Third Bank Stadium | Sergii Demianchuk | Match Report | |
| Wed | 2021-07-07 | 20:00 | Sac Republic | 0–0 | Roots | 8,118 | Papa Murphy’s Park | Mark Allatin | Match Report | |
| Wed | 2021-07-07 | 20:00 | Bold | 1–1 | RGV Toros | 686 | Bold Stadium | Elijio Arreguin | Match Report | |
| Sat | 2021-07-10 | 18:30 | B'ham Legion | 0–1 | Memphis | BBVA Compass Field | Joshua Encarnacion | Match Report | ||
| Sat | 2021-07-10 | 19:00 | Hartford | 2–2 | NY Red Bulls II | 5,002 | Dillon Stadium | Kyle Johnston | Match Report | |
| Sat | 2021-07-10 | 19:00 | Charlotte Ind'ence | 1–1 | Phx Rising | 2,283 | American Legion Memorial Stadium | Elvis Osmanovic | Match Report | |
| Fri | 2021-07-09 | 19:30 | New Mexico Utd | 3–1 | CS Switchbacks | 9,728 | Isotopes Park | Matthew Thompson | Match Report | |
| Sat | 2021-07-10 | 19:30 | Atlanta 2 | 0–1 | Sporting KC II | 728 | Fifth Third Bank Stadium | Izlen Peksenar | Match Report | |
| Fri | 2021-07-09 | 20:00 | Monarchs | 1–3 | El Paso | 763 | Zions Bank Stadium | Adam Kilpatrick | Match Report | |
| Sun | 2021-07-11 | 17:00 | Loudoun Utd | 1–4 | Miami FC | 402 | Segra Field | John Matto | Match Report | |
| Sat | 2021-07-10 | 19:00 | Roots | 1–2 | LV Lights FC | 813 | Las Positas College Turf Field | Ismir Pekmic | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-07-10 | 19:00 | FC Tulsa | 3–2 | Louisville City | 3,006 | ONEOK Field | Mathew Corrigan | Match Report | |
| Sat | 2021-07-10 | 20:00 | Sac Republic | 0–2 | Orange County | 9,316 | Papa Murphy’s Park | Joseph Salinas | Match Report | |
| Sun | 2021-07-11 | 17:00 | Galaxy II | 1–1 | Tacoma | Dignity Health Sports Park | Mark Allatin | Match Report | ||
| Tue | 2021-07-13 | 19:30 | TB Rowdies | 0–1 | Hartford | 2,943 | Al Lang Stadium | Kevin Broadley | Match Report | |
| Mon | 2021-07-12 | 19:30 | New Mexico Utd | 2–1 | Charleston | 7,576 | Isotopes Park | Jon Freemon | Match Report | |
| Wed | 2021-07-14 | 19:30 | Louisville City | 3–1 | OKC Energy | 10,032 | Lynn Family Stadium | Thomas Snyder | Match Report | |
| Wed | 2021-07-14 | 19:30 | Loyal | 2–1 | Orange County | 5,462 | Torero Stadium | Malik Badawi | Match Report | |
| Wed | 2021-07-14 | 19:30 | LV Lights FC | 1–2 | Sac Republic | Cashman Field | Ricardo Fierro | Match Report | ||
| Sat | 2021-07-17 | 12:00 | CS Switchbacks | 2–3 | San Antonio | 4,875 | Weidner Field | Mark Allatin | Match Report | |
| Sat | 2021-07-17 | 19:00 | Indy Eleven | 1–1 | Memphis | 6,999 | Michael A. Carroll Stadium | Luis Arroyo | Match Report | |
| Sat | 2021-07-17 | 19:00 | Pittsburgh | 1–0 | Loudoun Utd | 3,483 | Highmark Stadium | Kyle Johnston | Match Report | |
| Sat | 2021-07-17 | 19:30 | Charleston | 3–1 | Hartford | 3,515 | Patriots Point Soccer Complex | Sergii Demianchuk | Match Report | |
| Sat | 2021-07-17 | 19:30 | Louisville City | 2–0 | Atlanta 2 | Lynn Family Stadium | Gerald Flores | Match Report | ||
| Sat | 2021-07-17 | 19:30 | Miami FC | 2–1 | TB Rowdies | 723 | FIU Soccer Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2021-07-17 | 17:00 | Orange County | 0–2 | RGV Toros | 2,517 | Orange Country Great Park Championship S... | Ricardo Fierro | Match Report | |
| Sat | 2021-07-17 | 19:00 | FC Tulsa | 1–2 | OKC Energy | 5,009 | ONEOK Field | Brad Jensen | Match Report | |
| Sat | 2021-07-17 | 19:30 | Phx Rising | 5–0 | Galaxy II | 827 | Casino Arizona Field | Mathew Corrigan | Match Report | |
| Sat | 2021-07-17 | 20:30 | El Paso | 1–0 | LV Lights FC | 7,019 | Southwest University Park | Jeremy Scheer | Match Report | |
| Sun | 2021-07-18 | 20:00 | Bold | 1–0 | Monarchs | 954 | Bold Stadium | Greg Dopka | Match Report | |
| Wed | 2021-07-21 | 20:30 | San Antonio | 3–0 | New Mexico Utd | 5,601 | Toyota Field | Natalie Simon | Match Report | |
| Fri | 2021-07-23 | 19:00 | NY Red Bulls II | 1–3 | Pittsburgh | 577 | MSU Soccer Park at Pittser Field | Ben Meyer | Match Report | |
| Fri | 2021-07-23 | 19:30 | Charleston | 2–0 | Charlotte Ind'ence | 2,977 | Patriots Point Soccer Complex | Joshua Encarnacion | Match Report | |
| Sat | 2021-07-24 | 19:00 | Indy Eleven | 1–2 | B'ham Legion | 5,999 | Michael A. Carroll Stadium | Kevin Fikar | Match Report | |
| Fri | 2021-07-23 | 19:00 | CS Switchbacks | 1–1 | Louisville City | 6,488 | Weidner Field | Jeremy Scheer | Match Report | |
| Sat | 2021-07-24 | 19:00 | Hartford | 2–0 | Miami FC | 4,983 | Dillon Stadium | Mathew Corrigan | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-07-24 | 19:30 | TB Rowdies | 3–1 | Loudoun Utd | 4,920 | Al Lang Stadium | Sergii Demianchuk | Match Report | |
| Fri | 2021-07-23 | 20:00 | Monarchs | 3–2 | LV Lights FC | 885 | Zions Bank Stadium | Brandon Stevis | Match Report | |
| Sat | 2021-07-24 | 19:00 | Orange County | 2–2 | Sac Republic | 3,121 | Orange Country Great Park Championship S... | Adorae Monroy | Match Report | |
| Sat | 2021-07-24 | 19:30 | Memphis | 1–0 | FC Tulsa | 5,425 | AutoZone Park | Adam Kilpatrick | Match Report | |
| Sat | 2021-07-24 | 19:30 | OKC Energy | 0–0 | Sporting KC II | 2,171 | Taft Stadium | Matthew Franz | Match Report | |
| Sat | 2021-07-24 | 19:30 | Loyal | 0–1 | Phx Rising | Torero Stadium | Lukasz Szpala | Match Report | ||
| Sat | 2021-07-24 | 19:30 | New Mexico Utd | 0–0 | El Paso | 10,303 | Isotopes Park | Greg Dopka | Match Report | |
| Sat | 2021-07-24 | 20:00 | RGV Toros | 1–1 | Bold | H-E-B Park | Brad Jensen | Match Report | ||
| Sun | 2021-07-25 | 17:00 | Galaxy II | 3–0 | Roots | Dignity Health Sports Park | Matthew Thompson | Match Report | ||
| Tue | 2021-07-27 | 19:00 | Loudoun Utd | 3–5 | Charleston | 556 | Segra Field | John Griggs | Match Report | |
| Tue | 2021-07-27 | 19:30 | LV Lights FC | 3–1 | Orange County | Cashman Field | Elijio Arreguin | Match Report | ||
| Wed | 2021-07-28 | 19:30 | Atlanta 2 | 2–1 | FC Tulsa | 769 | Fifth Third Bank Stadium | Jonathan Bilinski | Match Report | |
| Wed | 2021-07-28 | 19:00 | Sporting KC II | 1–2 | Louisville City | Children's Mercy Park | Kevin Broadley | Match Report | ||
| Wed | 2021-07-28 | 19:30 | San Antonio | 1–2 | El Paso | Toyota Field | Malik Badawi | Match Report | ||
| Thu | 2021-07-29 | 19:00 | Tacoma | 2–1 | Loyal | 970 | Cheney Stadium | Elton Garcia | Match Report | |
| Sat | 2021-07-31 | 18:30 | B'ham Legion | 2–2 | Atlanta 2 | BBVA Compass Field | John Matto | Match Report | ||
| Sat | 2021-07-31 | 19:00 | Charlotte Ind'ence | 2–0 | TB Rowdies | 2,371 | American Legion Memorial Stadium | Jeremy Scheer | Match Report | |
| Sat | 2021-07-31 | 19:00 | Loudoun Utd | 1–3 | CS Switchbacks | 905 | Segra Field | Izlen Peksenar | Match Report | |
| Sat | 2021-07-31 | 19:00 | Pittsburgh | 3–1 | Hartford | 3,879 | Highmark Stadium | Matthew Thompson | Match Report | |
| Sat | 2021-07-31 | 19:30 | Louisville City | 2–1 | OKC Energy | 10,602 | Lynn Family Stadium | Adam Kilpatrick | Match Report | |
| Sun | 2021-08-01 | 13:30 | Tacoma | 0–0 | New Mexico Utd | Cheney Stadium | Matthew Franz | Match Report | ||
| Sun | 2021-08-01 | 16:00 | Sporting KC II | 1–2 | Memphis | Children's Mercy Park | Mathew Corrigan | Match Report | ||
| Sat | 2021-07-31 | 17:30 | Roots | 0–3 | Orange County | Las Positas College Turf Field | Jonathan Bilinski | Match Report | ||
| Sun | 2021-08-01 | 19:30 | Miami FC | 3–2 | Charleston | FIU Soccer Stadium | Brandon Stevis | Match Report | ||
| Sat | 2021-07-31 | 19:30 | Phx Rising | 3–1 | RGV Toros | 6,740 | Casino Arizona Field | Sergii Demianchuk | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-07-31 | 20:00 | Sac Republic | 3–1 | NY Red Bulls II | 9,283 | Papa Murphy’s Park | Elijio Arreguin | Match Report | |
| Sat | 2021-07-31 | 20:00 | Bold | 0–3 | San Antonio | 1,577 | Bold Stadium | Jervis Atagana | Match Report | |
| Sat | 2021-07-31 | 20:30 | El Paso | 3–1 | Monarchs | 6,459 | Southwest University Park | Luis Guardia | Match Report | |
| Sun | 2021-08-01 | 17:00 | Galaxy II | 0–2 | Loyal | Dignity Health Sports Park | Katja Koroleva | Match Report | ||
| Wed | 2021-08-04 | 19:00 | Hartford | 1–1 | Miami FC | 5,065 | Dillon Stadium | Danielle Chesky | Match Report | |
| Wed | 2021-08-04 | 19:00 | FC Tulsa | 0–2 | Indy Eleven | 3,099 | ONEOK Field | Elvis Osmanovic | Match Report | |
| Wed | 2021-08-04 | 19:00 | Roots | 0–1 | Phx Rising | 3,218 | Laney College Field | Ricardo Fierro | Match Report | |
| Wed | 2021-08-04 | 19:00 | B'ham Legion | 3–1 | Atlanta 2 | BBVA Compass Field | Ben Meyer | Match Report | ||
| Wed | 2021-08-04 | 20:00 | El Paso | 2–0 | San Antonio | 4,688 | Southwest University Park | Brad Jensen | Match Report | |
| Wed | 2021-08-04 | 20:00 | Bold | 2–1 | CS Switchbacks | 547 | Bold Stadium | Gerald Flores | Match Report | |
| Wed | 2021-08-04 | 20:00 | Monarchs | 0–3 | RGV Toros | 1,790 | Zions Bank Stadium | William Hoffman | Match Report | |
| Fri | 2021-08-06 | 19:00 | NY Red Bulls II | 1–2 | TB Rowdies | 587 | MSU Soccer Park at Pittser Field | Calin Radosav | Match Report | |
| Thu | 2021-08-05 | 19:00 | Tacoma | 1–1 | Sac Republic | Cheney Stadium | Joshua Encarnacion | Match Report | ||
| Fri | 2021-08-06 | 19:00 | Loudoun Utd | 0–0 | Charlotte Ind'ence | 519 | Segra Field | Gabriele Giusti | Match Report | |
| Fri | 2021-08-06 | 19:30 | Charleston | 2–3 | Pittsburgh | 2,565 | Patriots Point Soccer Complex | Mathew Corrigan | Match Report | |
| Sat | 2021-08-07 | 19:30 | Louisville City | 4–1 | Sporting KC II | 10,470 | Lynn Family Stadium | Elton Garcia | Match Report | |
| Sun | 2021-08-08 | 13:30 | Tacoma | 3–1 | Roots | 1,007 | Cheney Stadium | Adorae Monroy | Match Report | |
| Sat | 2021-08-07 | 19:00 | FC Tulsa | 3–1 | B'ham Legion | 3,389 | ONEOK Field | Jeremy Scheer | Match Report | |
| Sat | 2021-08-07 | 19:00 | Orange County | 2–3 | Galaxy II | 3,991 | Orange Country Great Park Championship S... | Greg Dopka | Match Report | |
| Sat | 2021-08-07 | 19:00 | CS Switchbacks | 4–2 | Hartford | 6,570 | Weidner Field | Malik Badawi | Match Report | |
| Sat | 2021-08-07 | 19:30 | Loyal | 0–1 | Monarchs | 3,518 | Torero Stadium | Mark Allatin | Match Report | |
| Sat | 2021-08-07 | 19:30 | LV Lights FC | 2–2 | Phx Rising | Cashman Field | Melvin Rivas | Match Report | ||
| Sat | 2021-08-07 | 19:30 | OKC Energy | 4–1 | Memphis | 2,183 | Taft Stadium | Kevin Broadley | Match Report | |
| Sun | 2021-08-08 | 19:30 | Atlanta 2 | 6–2 | Indy Eleven | 677 | Fifth Third Bank Stadium | William Steffen | Match Report | |
| Sat | 2021-08-07 | 20:30 | El Paso | 3–0 | Bold | 5,348 | Southwest University Park | Michael Radchuk | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-08-08 | 19:30 | RGV Toros | 1–2 | San Antonio | 3,495 | H-E-B Park | Elvis Osmanovic | Match Report | |
| Tue | 2021-08-10 | 19:00 | NY Red Bulls II | 2–3 | Charlotte Ind'ence | 496 | MSU Soccer Park at Pittser Field | Luis Arroyo | Match Report | |
| Wed | 2021-08-11 | 18:00 | Pittsburgh | 2–3 | Miami FC | 2,821 | Highmark Stadium | Ismir Pekmic | Match Report | |
| Tue | 2021-08-10 | 19:00 | Memphis | 1–1 | CS Switchbacks | 3,512 | AutoZone Park | John Matto | Match Report | |
| Wed | 2021-08-11 | 19:30 | Atlanta 2 | 2–2 | OKC Energy | Fifth Third Bank Stadium | Kyle Johnston | Match Report | ||
| Wed | 2021-08-11 | 19:00 | Roots | 0–0 | Sac Republic | Laney College Field | William Hoffman | Match Report | ||
| Wed | 2021-08-11 | 19:00 | B'ham Legion | 4–2 | Sporting KC II | BBVA Compass Field | John Griggs | Match Report | ||
| Fri | 2021-08-13 | 19:30 | TB Rowdies | 1–0 | Hartford | 3,682 | Al Lang Stadium | Elton Garcia | Match Report | |
| Fri | 2021-08-13 | 19:30 | Charleston | 1–0 | Loudoun Utd | 3,059 | Patriots Point Soccer Complex | Elvis Osmanovic | Match Report | |
| Sat | 2021-08-14 | 14:00 | Roots | 2–1 | Galaxy II | 3,451 | Laney College Field | Sergii Demianchuk | Match Report | |
| Sat | 2021-08-14 | 16:00 | Sporting KC II | 1–4 | Atlanta 2 | Children's Mercy Park | Jon Freemon | Match Report | ||
| Sat | 2021-08-14 | 19:00 | Indy Eleven | 2–1 | OKC Energy | 5,999 | Michael A. Carroll Stadium | Joshua Encarnacion | Match Report | |
| Sat | 2021-08-14 | 19:00 | Charlotte Ind'ence | 1–0 | Pittsburgh | American Legion Memorial Stadium | Brandon Stevis | Match Report | ||
| Sat | 2021-08-14 | 19:30 | Louisville City | 2–1 | FC Tulsa | 10,675 | Lynn Family Stadium | Malik Badawi | Match Report | |
| Sat | 2021-08-14 | 19:00 | RGV Toros | 2–5 | CS Switchbacks | 3,018 | H-E-B Park | Michael Radchuk | Match Report | |
| Sat | 2021-08-14 | 19:30 | Loyal | 1–2 | Tacoma | 3,310 | Torero Stadium | Mathew Corrigan | Match Report | |
| Sat | 2021-08-14 | 19:30 | Phx Rising | 1–1 | Orange County | Casino Arizona Field | Gerald Flores | Match Report | ||
| Sat | 2021-08-14 | 19:30 | Memphis | 1–1 | B'ham Legion | 4,864 | AutoZone Park | Gabriele Giusti | Match Report | |
| Sat | 2021-08-14 | 19:30 | New Mexico Utd | 1–1 | El Paso | 10,418 | Isotopes Park | Lukasz Szpala | Match Report | |
| Sat | 2021-08-14 | 20:00 | Bold | 0–0 | Miami FC | Bold Stadium | Jeremy Scheer | Match Report | ||
| Sat | 2021-08-14 | 20:00 | Sac Republic | 2–1 | LV Lights FC | 9,329 | Papa Murphy’s Park | Calin Radosav | Match Report | |
| Tue | 2021-08-17 | 19:00 | Hartford | 2–1 | Charleston | 4,424 | Dillon Stadium | Mark Allatin | Match Report | |
| Wed | 2021-08-18 | 18:00 | Pittsburgh | 0–0 | TB Rowdies | Highmark Stadium | Jon Freemon | Match Report | ||
| Wed | 2021-08-18 | 19:00 | Loudoun Utd | 4–1 | Indy Eleven | 310 | Segra Field | Matthew Franz | Match Report | |
| Tue | 2021-08-17 | 20:00 | Bold | 1–1 | RGV Toros | 531 | Bold Stadium | Tori Penso | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-08-18 | 19:00 | Orange County | 0–3 | Tacoma | 2,111 | Orange Country Great Park Championship S... | Kevin Broadley | Match Report | |
| Wed | 2021-08-18 | 19:30 | Loyal | 5–1 | LV Lights FC | 2,654 | Torero Stadium | Matthew Thompson | Match Report | |
| Wed | 2021-08-18 | 19:30 | New Mexico Utd | 1–1 | Roots | 6,047 | Isotopes Park | Elton Garcia | Match Report | |
| Fri | 2021-08-20 | 19:00 | NY Red Bulls II | 2–3 | Charleston | 463 | MSU Soccer Park at Pittser Field | Jeremy Scheer | Match Report | |
| Sat | 2021-08-21 | 19:00 | Charlotte Ind'ence | 3–3 | CS Switchbacks | 1,902 | American Legion Memorial Stadium | Ben Meyer | Match Report | |
| Sun | 2021-08-22 | 16:00 | B'ham Legion | 1–2 | FC Tulsa | BBVA Compass Field | Sergii Demianchuk | Match Report | ||
| Sun | 2021-08-22 | 16:00 | Sporting KC II | 1–1 | Indy Eleven | Children's Mercy Park | Greg Dopka | Match Report | ||
| Sun | 2021-08-22 | 17:00 | OKC Energy | 0–0 | Louisville City | 1,993 | Taft Stadium | Calin Radosav | Match Report | |
| Sun | 2021-08-22 | 18:30 | Miami FC | 2–0 | Hartford | 574 | Riccardo Silva Stadium | Elton Garcia | Match Report | |
| Sun | 2021-08-22 | 19:00 | Pittsburgh | 4–1 | Atlanta 2 | 3,177 | Highmark Stadium | Luis Guardia | Match Report | |
| Sat | 2021-08-21 | 19:30 | Loyal | 1–2 | Orange County | 3,872 | Torero Stadium | Brad Jensen | Match Report | |
| Sat | 2021-08-21 | 19:30 | LV Lights FC | 1–3 | Roots | Cashman Field | Mathew Corrigan | Match Report | ||
| Sat | 2021-08-21 | 19:30 | Phx Rising | 0–0 | Sac Republic | Casino Arizona Field | Malik Badawi | Match Report | ||
| Sat | 2021-08-21 | 20:30 | El Paso | 3–1 | RGV Toros | 7,017 | Southwest University Park | Matthew Thompson | Match Report | |
| Mon | 2021-08-23 | 19:00 | Loudoun Utd | 0–2 | TB Rowdies | 360 | Segra Field | Luis Arroyo | Match Report | |
| Mon | 2021-08-23 | 20:00 | Bold | 1–1 | New Mexico Utd | 608 | Bold Stadium | Brandon Stevis | Match Report | |
| Wed | 2021-08-25 | 19:00 | Roots | 3–1 | Phx Rising | Las Positas College Turf Field | William Hoffman | Match Report | ||
| Wed | 2021-08-25 | 19:00 | FC Tulsa | 2–1 | Memphis | 2,302 | ONEOK Field | Jervis Atagana | Match Report | |
| Sat | 2021-08-28 | 18:30 | B'ham Legion | 2–1 | Louisville City | BBVA Compass Field | Brad Jensen | Match Report | ||
| Sat | 2021-08-28 | 19:00 | Indy Eleven | 2–0 | Monarchs | 5,999 | Michael A. Carroll Stadium | DeShun Beard | Match Report | |
| Sat | 2021-08-28 | 19:00 | Hartford | 2–3 | Pittsburgh | 5,500 | Dillon Stadium | Jonathan Bilinski | Match Report | |
| Fri | 2021-08-27 | 19:30 | LV Lights FC | 2–3 | Galaxy II | Cashman Field | Héctor Hernández | Match Report | ||
| Sat | 2021-08-28 | 19:30 | Charleston | 0–0 | Orange County | 3,046 | Patriots Point Soccer Complex | Luis Arroyo | Match Report | |
| Sat | 2021-08-28 | 19:30 | TB Rowdies | 2–0 | Charlotte Ind'ence | 4,461 | Al Lang Stadium | Katja Koroleva | Match Report | |
| Sun | 2021-08-29 | 16:00 | Sporting KC II | 0–0 | Memphis | Children's Mercy Park | Jeremy Scheer | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-08-29 | 17:00 | OKC Energy | 2–1 | RGV Toros | 1,645 | Taft Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2021-08-28 | 17:30 | Roots | 3–1 | Tacoma | 4,118 | Laney College Field | Elijio Arreguin | Match Report | |
| Sun | 2021-08-29 | 18:30 | Miami FC | 3–0 | NY Red Bulls II | Riccardo Silva Stadium | Matthew Thompson | Match Report | ||
| Sat | 2021-08-28 | 19:00 | FC Tulsa | 3–1 | Atlanta 2 | 3,221 | ONEOK Field | Laura Rodriguez | Match Report | |
| Sat | 2021-08-28 | 19:00 | CS Switchbacks | 4–1 | Bold | 8,023 | Weidner Field | Sergii Demianchuk | Match Report | |
| Sat | 2021-08-28 | 19:30 | Phx Rising | 3–2 | New Mexico Utd | Casino Arizona Field | Ismir Pekmic | Match Report | ||
| Sat | 2021-08-28 | 19:30 | San Antonio | 2–1 | El Paso | 4,883 | Toyota Field | Ricardo Fierro | Match Report | |
| Sat | 2021-08-28 | 20:00 | Sac Republic | 1–3 | Loyal | 8,010 | Papa Murphy’s Park | Gerald Flores | Match Report | |
| Wed | 2021-09-01 | 18:00 | Pittsburgh | 1–0 | NY Red Bulls II | 2,003 | Highmark Stadium | Adam Kilpatrick | Match Report | |
| Wed | 2021-09-01 | 19:00 | Sporting KC II | 0–1 | B'ham Legion | Children's Mercy Park | Brandon Stevis | Match Report | ||
| Wed | 2021-09-01 | 19:00 | Memphis | 0–1 | OKC Energy | 3,816 | AutoZone Park | Gabriele Giusti | Match Report | |
| Wed | 2021-09-01 | 19:30 | Galaxy II | 3–3 | Sac Republic | Dignity Health Sports Park | William Hoffman | Match Report | ||
| Wed | 2021-09-01 | 19:30 | San Antonio | 3–2 | Monarchs | 3,836 | Toyota Field | Joshua Encarnacion | Match Report | |
| Thu | 2021-09-02 | 19:00 | Tacoma | 2–1 | LV Lights FC | 844 | Cheney Stadium | Lorenzo Hernandez | Match Report | |
| Fri | 2021-09-03 | 19:30 | Louisville City | 0–1 | FC Tulsa | 10,206 | Lynn Family Stadium | John Matto | Match Report | |
| Fri | 2021-09-03 | 19:30 | TB Rowdies | 3–0 | Roots | 3,514 | Al Lang Stadium | Gerald Flores | Match Report | |
| Sat | 2021-09-04 | 16:00 | Sporting KC II | 3–0 | OKC Energy | Children's Mercy Park | Malik Badawi | Match Report | ||
| Sat | 2021-09-04 | 19:00 | Indy Eleven | 0–1 | Atlanta 2 | 4,999 | Michael A. Carroll Stadium | Calin Radosav | Match Report | |
| Fri | 2021-09-03 | 19:00 | Orange County | 2–2 | El Paso | 3,215 | Orange Country Great Park Championship S... | Mark Allatin | Match Report | |
| Sat | 2021-09-04 | 19:00 | NY Red Bulls II | 2–0 | Hartford | 803 | MSU Soccer Park at Pittser Field | Kenneth Rojas | Match Report | |
| Sat | 2021-09-04 | 19:00 | Charlotte Ind'ence | 2–2 | Miami FC | 1,672 | American Legion Memorial Stadium | Adam Kilpatrick | Match Report | |
| Sun | 2021-09-05 | 13:30 | Tacoma | 1–3 | Phx Rising | 1,185 | Cheney Stadium | Michael Radchuk | Match Report | |
| Sun | 2021-09-05 | 15:00 | Loyal | 4–2 | Galaxy II | 3,600 | Torero Stadium | Jonathan Bilinski | Match Report | |
| Sat | 2021-09-04 | 19:00 | Memphis | 3–2 | B'ham Legion | 3,162 | AutoZone Park | Luis Guardia | Match Report | |
| Sat | 2021-09-04 | 19:30 | San Antonio | 1–1 | Pittsburgh | 5,009 | Toyota Field | Elijio Arreguin | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-04 | 19:30 | New Mexico Utd | 3–2 | CS Switchbacks | 7,077 | Isotopes Park | Joshua Encarnacion | Match Report | |
| Sat | 2021-09-04 | 19:30 | RGV Toros | 1–1 | Loudoun Utd | 3,052 | H-E-B Park | Elton Garcia | Match Report | |
| Sun | 2021-09-05 | 19:00 | LV Lights FC | 1–3 | Sac Republic | Cashman Field | Brandon Stevis | Match Report | ||
| Tue | 2021-09-07 | 19:00 | Charleston | 0–1 | TB Rowdies | 2,024 | Patriots Point Soccer Complex | Matthew Thompson | Match Report | |
| Tue | 2021-09-07 | 19:00 | Hartford | 2–4 | Louisville City | 4,159 | Dillon Stadium | Sergii Demianchuk | Match Report | |
| Wed | 2021-09-08 | 19:00 | Loudoun Utd | 0–5 | Charlotte Ind'ence | Segra Field | Alyssa Nichols | Match Report | ||
| Tue | 2021-09-07 | 20:00 | Bold | 2–1 | San Antonio | 650 | Bold Stadium | Mathew Corrigan | Match Report | |
| Wed | 2021-09-08 | 19:00 | FC Tulsa | 2–1 | Indy Eleven | 2,312 | ONEOK Field | John Griggs | Match Report | |
| Wed | 2021-09-08 | 19:00 | LV Lights FC | 0–1 | Roots | Cashman Field | Mark Allatin | Match Report | ||
| Wed | 2021-09-08 | 19:00 | CS Switchbacks | 2–0 | Monarchs | 4,792 | Weidner Field | Ricardo Fierro | Match Report | |
| Sat | 2021-09-11 | 19:00 | Charlotte Ind'ence | 2–0 | Hartford | 1,663 | American Legion Memorial Stadium | John Griggs | Match Report | |
| Sat | 2021-09-11 | 19:00 | Pittsburgh | 5–0 | Loudoun Utd | 3,502 | Highmark Stadium | Calin Radosav | Match Report | |
| Sat | 2021-09-11 | 19:00 | Indy Eleven | 1–0 | Sporting KC II | 5,999 | Michael A. Carroll Stadium | Jonathan Bilinski | Match Report | |
| Sat | 2021-09-11 | 19:30 | TB Rowdies | 6–0 | NY Red Bulls II | 4,413 | Al Lang Stadium | Brandon Stevis | Match Report | |
| Fri | 2021-09-10 | 20:00 | Bold | 1–0 | New Mexico Utd | 926 | Bold Stadium | Kevin Broadley | Match Report | |
| Sun | 2021-09-12 | 17:00 | OKC Energy | 1–1 | Louisville City | 1,579 | Taft Stadium | Matthew Thompson | Match Report | |
| Sat | 2021-09-11 | 19:00 | Roots | 0–0 | Loyal | 4,367 | Laney College Field | Jeremy Scheer | Match Report | |
| Sat | 2021-09-11 | 19:00 | Memphis | 0–2 | Miami FC | 3,865 | AutoZone Park | Ben Meyer | Match Report | |
| Sat | 2021-09-11 | 19:00 | FC Tulsa | 1–1 | B'ham Legion | 3,439 | ONEOK Field | Natalie Simon | Match Report | |
| Sat | 2021-09-11 | 19:00 | Monarchs | 0–1 | San Antonio | 1,649 | Zions Bank Stadium | Gerald Flores | Match Report | |
| Sat | 2021-09-11 | 19:00 | Orange County | 3–0 | LV Lights FC | 4,223 | Orange Country Great Park Championship S... | Malik Badawi | Match Report | |
| Sat | 2021-09-11 | 19:00 | CS Switchbacks | 1–1 | RGV Toros | 6,474 | Weidner Field | Elijio Arreguin | Match Report | |
| Sat | 2021-09-11 | 19:30 | Galaxy II | 3–4 | Phx Rising | Dignity Health Sports Park | Ricardo Fierro | Match Report | ||
| Sat | 2021-09-11 | 20:30 | El Paso | 2–0 | Sac Republic | 7,320 | Southwest University Park | Joshua Encarnacion | Match Report | |
| Wed | 2021-09-15 | 19:00 | Hartford | 2–0 | Monarchs | 4,705 | Dillon Stadium | Kevin Broadley | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Wed | 2021-09-15 | 19:00 | NY Red Bulls II | 1–2 | San Antonio | 468 | MSU Soccer Park at Pittser Field | Jonathan Bilinski | Match Report | |
| Wed | 2021-09-15 | 19:30 | Atlanta 2 | 1–1 | Charleston | 620 | Fifth Third Bank Stadium | Sergii Demianchuk | Match Report | |
| Wed | 2021-09-15 | 19:00 | Roots | 3–1 | Tacoma | Las Positas College Turf Field | Corbyn May | Match Report | ||
| Wed | 2021-09-15 | 19:00 | CS Switchbacks | 0–0 | El Paso | 5,370 | Weidner Field | William Hoffman | Match Report | |
| Wed | 2021-09-15 | 19:30 | Phx Rising | 4–1 | LV Lights FC | Casino Arizona Field | Luis Guardia | Match Report | ||
| Sat | 2021-09-18 | 18:30 | B'ham Legion | 1–1 | OKC Energy | BBVA Compass Field | Matthew Franz | Match Report | ||
| Sat | 2021-09-18 | 19:00 | Indy Eleven | 0–2 | Louisville City | 6,499 | Michael A. Carroll Stadium | Jeremy Scheer | Match Report | |
| Sat | 2021-09-18 | 19:00 | Charlotte Ind'ence | 1–0 | Pittsburgh | 4,094 | American Legion Memorial Stadium | Gabriele Giusti | Match Report | |
| Sat | 2021-09-18 | 19:30 | Atlanta 2 | 0–2 | TB Rowdies | 699 | Fifth Third Bank Stadium | Melvin Rivas | Match Report | |
| Sat | 2021-09-18 | 19:30 | Miami FC | 1–1 | Charleston | 829 | Riccardo Silva Stadium | Calin Radosav | Match Report | |
| Sun | 2021-09-19 | 13:00 | NY Red Bulls II | 0–3 | Memphis | 506 | MSU Soccer Park at Pittser Field | Sergii Demianchuk | Match Report | |
| Sun | 2021-09-19 | 15:00 | Loyal | 1–0 | Tacoma | 3,800 | Torero Stadium | Brandon Stevis | Match Report | |
| Sat | 2021-09-18 | 19:00 | Roots | 0–1 | Galaxy II | 4,802 | Laney College Field | Elvis Osmanovic | Match Report | |
| Sat | 2021-09-18 | 19:00 | FC Tulsa | 0–1 | Bold | 3,588 | ONEOK Field | Gerald Flores | Match Report | |
| Sat | 2021-09-18 | 19:30 | New Mexico Utd | 2–1 | Monarchs | 7,564 | Isotopes Park | Mathew Corrigan | Match Report | |
| Sat | 2021-09-18 | 19:30 | RGV Toros | 1–2 | CS Switchbacks | 2,905 | H-E-B Park | Lukasz Szpala | Match Report | |
| Sat | 2021-09-18 | 19:30 | Sac Republic | 0–1 | San Antonio | 9,483 | Papa Murphy’s Park | Ismir Pekmic | Match Report | |
| Sat | 2021-09-18 | 19:30 | Phx Rising | 2–1 | Orange County | Casino Arizona Field | Elton Garcia | Match Report | ||
| Wed | 2021-09-22 | 19:00 | Charleston | 2–3 | NY Red Bulls II | 2,055 | Patriots Point Soccer Complex | John Matto | Match Report | |
| Wed | 2021-09-22 | 19:00 | Charlotte Ind'ence | 2–0 | Miami FC | 1,113 | American Legion Memorial Stadium | Elijio Arreguin | Match Report | |
| Wed | 2021-09-22 | 19:30 | Atlanta 2 | 0–4 | B'ham Legion | 717 | Fifth Third Bank Stadium | Luis Arroyo | Match Report | |
| Wed | 2021-09-22 | 19:00 | Tacoma | 0–1 | Sac Republic | 1,993 | Cheney Stadium | Mark Allatin | Match Report | |
| Wed | 2021-09-22 | 19:00 | Roots | 2–1 | Loyal | Laney College Field | Joshua Encarnacion | Match Report | ||
| Wed | 2021-09-22 | 19:00 | Memphis | 1–0 | Indy Eleven | 3,716 | AutoZone Park | Adam Kilpatrick | Match Report | |
| Wed | 2021-09-22 | 20:00 | Bold | 2–2 | El Paso | 1,022 | Bold Stadium | Natalie Simon | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-09-25 | 19:00 | Pittsburgh | 3–3 | Charleston | 3,529 | Highmark Stadium | Melvin Rivas | Match Report | |
| Fri | 2021-09-24 | 19:00 | Sporting KC II | 1–1 | FC Tulsa | Children's Mercy Park | Kevin Fikar | Match Report | ||
| Sat | 2021-09-25 | 19:00 | Hartford | 1–2 | TB Rowdies | 5,138 | Dillon Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-09-25 | 19:30 | Miami FC | 6–1 | Loudoun Utd | 418 | Riccardo Silva Stadium | Brandon Stevis | Match Report | |
| Sun | 2021-09-26 | 14:00 | Sac Republic | 0–2 | Galaxy II | 9,265 | Papa Murphy’s Park | Mathew Corrigan | Match Report | |
| Sun | 2021-09-26 | 16:00 | B'ham Legion | 2–1 | Charlotte Ind'ence | BBVA Compass Field | Gerald Flores | Match Report | ||
| Sun | 2021-09-26 | 17:00 | OKC Energy | 2–0 | Indy Eleven | 1,960 | Taft Stadium | Kevin Broadley | Match Report | |
| Sat | 2021-09-25 | 18:00 | CS Switchbacks | 3–1 | Bold | 6,355 | Weidner Field | Jonathan Bilinski | Match Report | |
| Sat | 2021-09-25 | 19:00 | LV Lights FC | 2–4 | Loyal | Cashman Field | Elijio Arreguin | Match Report | ||
| Sat | 2021-09-25 | 19:00 | Memphis | 1–1 | Louisville City | 3,616 | AutoZone Park | Calin Radosav | Match Report | |
| Sat | 2021-09-25 | 19:00 | Tacoma | 1–2 | Phx Rising | 1,370 | Cheney Stadium | Brad Jensen | Match Report | |
| Sat | 2021-09-25 | 19:00 | Orange County | 2–1 | Roots | 4,014 | Orange Country Great Park Championship S... | William Hoffman | Match Report | |
| Sat | 2021-09-25 | 19:30 | San Antonio | 0–1 | New Mexico Utd | 5,503 | Toyota Field | Elton Garcia | Match Report | |
| Sat | 2021-09-25 | 19:30 | RGV Toros | 3–2 | Atlanta 2 | 3,017 | H-E-B Park | Ricardo Fierro | Match Report | |
| Sun | 2021-09-26 | 19:00 | Monarchs | 0–0 | NY Red Bulls II | Zions Bank Stadium | Joseph Salinas | Match Report | ||
| Wed | 2021-09-29 | 19:30 | Atlanta 2 | 1–1 | Louisville City | 680 | Fifth Third Bank Stadium | John Griggs | Match Report | |
| Thu | 2021-09-30 | 19:00 | NY Red Bulls II | 3–3 | Loudoun Utd | 485 | MSU Soccer Park at Pittser Field | William Steffen | Match Report | |
| Wed | 2021-09-29 | 19:00 | New Mexico Utd | 2–0 | RGV Toros | 5,377 | Isotopes Park | Adam Kilpatrick | Match Report | |
| Wed | 2021-09-29 | 19:30 | OKC Energy | 1–1 | Indy Eleven | 3,677 | Taft Stadium | John Matto | Match Report | |
| Wed | 2021-09-29 | 19:30 | Galaxy II | 3–0 | Phx Rising | Dignity Health Sports Park | Ben Meyer | Match Report | ||
| Wed | 2021-09-29 | 20:00 | El Paso | 1–0 | Monarchs | 6,275 | Southwest University Park | Elton Garcia | Match Report | |
| Thu | 2021-09-30 | 20:00 | Hartford | 1–2 | Charlotte Ind'ence | 4,080 | Dillon Stadium | Elvis Osmanovic | Match Report | |
| Sat | 2021-10-02 | 19:00 | Charleston | 1–2 | TB Rowdies | 2,848 | Patriots Point Soccer Complex | Luis Guardia | Match Report | |
| Sat | 2021-10-02 | 19:00 | Indy Eleven | 1–1 | Atlanta 2 | 7,999 | Michael A. Carroll Stadium | Greg Dopka | Match Report | |
| Fri | 2021-10-01 | 19:00 | Sporting KC II | 0–1 | B'ham Legion | Children's Mercy Park | DeShun Beard | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-10-02 | 19:30 | Miami FC | 3–2 | Pittsburgh | 748 | Riccardo Silva Stadium | Katja Koroleva | Match Report | |
| Sun | 2021-10-03 | 15:00 | Louisville City | 3–1 | New Mexico Utd | 10,349 | Lynn Family Stadium | Mark Allatin | Match Report | |
| Sun | 2021-10-03 | 17:00 | OKC Energy | 0–1 | San Antonio | 1,828 | Taft Stadium | Lukasz Szpala | Match Report | |
| Sat | 2021-10-02 | 18:00 | CS Switchbacks | 1–1 | El Paso | 7,268 | Weidner Field | Gerald Flores | Match Report | |
| Sat | 2021-10-02 | 19:00 | Roots | 2–2 | LV Lights FC | 5,044 | Laney College Field | Michael Radchuk | Match Report | |
| Sun | 2021-10-03 | 19:00 | Charlotte Ind'ence | 5–1 | Loudoun Utd | 1,207 | American Legion Memorial Stadium | Jeremy Scheer | Match Report | |
| Sat | 2021-10-02 | 19:00 | Orange County | 0–1 | Phx Rising | 5,130 | Orange Country Great Park Championship S... | Matthew Thompson | Match Report | |
| Sat | 2021-10-02 | 19:00 | FC Tulsa | 0–3 | Memphis | 3,405 | ONEOK Field | Mathew Corrigan | Match Report | |
| Sat | 2021-10-02 | 19:30 | RGV Toros | 3–0 | Monarchs | 2,781 | H-E-B Park | Jonathan Bilinski | Match Report | |
| Sat | 2021-10-02 | 19:30 | Galaxy II | 0–3 | Loyal | Dignity Health Sports Park | Kevin Broadley | Match Report | ||
| Sat | 2021-10-02 | 19:30 | Sac Republic | 3–1 | Tacoma | 9,168 | Papa Murphy’s Park | Ricardo Fierro | Match Report | |
| Wed | 2021-10-06 | 19:00 | New Mexico Utd | 2–2 | Hartford | 6,444 | Isotopes Park | Brad Jensen | Match Report | |
| Wed | 2021-10-06 | 19:00 | Roots | 2–1 | Sac Republic | 3,548 | Laney College Field | Joseph Salinas | Match Report | |
| Wed | 2021-10-06 | 19:00 | Memphis | 3–1 | Sporting KC II | 3,029 | AutoZone Park | Danielle Chesky | Match Report | |
| Wed | 2021-10-06 | 20:00 | Bold | 1–0 | Tacoma | 1,144 | Bold Stadium | Luis Guardia | Match Report | |
| Wed | 2021-10-06 | 20:00 | El Paso | 3–3 | San Antonio | 5,250 | Southwest University Park | Sergii Demianchuk | Match Report | |
| Thu | 2021-10-07 | 20:00 | TB Rowdies | 4–2 | Charleston | 3,210 | Al Lang Stadium | Adam Kilpatrick | Match Report | |
| Sat | 2021-10-09 | 17:00 | New Mexico Utd | 1–1 | RGV Toros | 6,934 | Isotopes Park | Malik Badawi | Match Report | |
| Fri | 2021-10-08 | 19:00 | LV Lights FC | 0–1 | Galaxy II | Cashman Field | Thomas Snyder | Match Report | ||
| Fri | 2021-10-08 | 19:00 | Monarchs | 0–0 | CS Switchbacks | 1,497 | Zions Bank Stadium | Matthew Thompson | Match Report | |
| Sat | 2021-10-09 | 19:00 | Charlotte Ind'ence | 2–1 | NY Red Bulls II | 1,307 | American Legion Memorial Stadium | John Matto | Match Report | |
| Sat | 2021-10-09 | 19:30 | Louisville City | 4–3 | Sporting KC II | 10,762 | Lynn Family Stadium | Nabil Bensalah | Match Report | |
| Sun | 2021-10-10 | 13:00 | Loudoun Utd | 3–2 | Miami FC | Segra Field | Matthew Franz | Match Report | ||
| Sun | 2021-10-10 | 14:00 | Charleston | 4–3 | Hartford | 3,738 | Patriots Point Soccer Complex | Joshua Encarnacion | Match Report | |
| Sun | 2021-10-10 | 16:00 | B'ham Legion | 3–1 | Indy Eleven | BBVA Compass Field | Sergii Demianchuk | Match Report | ||
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2021-10-10 | 18:00 | Pittsburgh | 2–0 | TB Rowdies | 2,727 | Highmark Stadium | Ismir Pekmic | Match Report | |
| Sat | 2021-10-09 | 19:00 | FC Tulsa | 1–2 | El Paso | 4,156 | ONEOK Field | Brandon Stevis | Match Report | |
| Sat | 2021-10-09 | 19:00 | Tacoma | 4–1 | Orange County | 942 | Cheney Stadium | John Matto | Match Report | |
| Sat | 2021-10-09 | 19:30 | Phx Rising | 1–0 | Roots | 8,095 | Casino Arizona Field | Mathew Corrigan | Match Report | |
| Sat | 2021-10-09 | 19:30 | Loyal | 2–1 | Sac Republic | 6,000 | Torero Stadium | Elvis Osmanovic | Match Report | |
| Sun | 2021-10-10 | 19:30 | San Antonio | 4–2 | Memphis | 5,005 | Toyota Field | Kevin Broadley | Match Report | |
| Sun | 2021-10-10 | 20:00 | Bold | 1–1 | OKC Energy | 1,028 | Bold Stadium | Ricardo Fierro | Match Report | |
| Wed | 2021-10-13 | 19:00 | Loudoun Utd | 2–3 | Hartford | 368 | Segra Field | DeShun Beard | Match Report | |
| Wed | 2021-10-13 | 19:00 | Sporting KC II | 0–3 | Atlanta 2 | Children's Mercy Park | Thomas Snyder | Match Report | Match awarded to Atlanta 2 | |
| Wed | 2021-10-13 | 19:00 | Orange County | 1–0 | Phx Rising | 3,922 | Orange Country Great Park Championship S... | Mark Allatin | Match Report | |
| Wed | 2021-10-13 | 19:00 | Tacoma | 0–1 | LV Lights FC | 811 | Cheney Stadium | Matthew Thompson | Match Report | |
| Wed | 2021-10-13 | 19:00 | B'ham Legion | 3–1 | Bold | BBVA Compass Field | John Griggs | Match Report | ||
| Wed | 2021-10-13 | 19:00 | Memphis | 2–1 | Louisville City | 3,034 | AutoZone Park | Jonathan Bilinski | Match Report | |
| Wed | 2021-10-13 | 19:30 | Sac Republic | 1–1 | Galaxy II | 8,636 | Papa Murphy’s Park | Michael Radchuk | Match Report | |
| Wed | 2021-10-13 | 20:00 | El Paso | 4–2 | CS Switchbacks | 5,055 | Southwest University Park | Jeremy Scheer | Match Report | |
| Fri | 2021-10-15 | 19:30 | TB Rowdies | 1–1 | NY Red Bulls II | 6,882 | Al Lang Stadium | Alyssa Nichols | Match Report | |
| Sat | 2021-10-16 | 13:00 | Monarchs | 4–3 | Bold | 968 | Zions Bank Stadium | William Hoffman | Match Report | |
| Sat | 2021-10-16 | 14:00 | LV Lights FC | 3–6 | Phx Rising | Cashman Field | Calin Radosav | Match Report | ||
| Sat | 2021-10-16 | 18:00 | Memphis | 4–2 | Atlanta 2 | 4,482 | AutoZone Park | Gerald Flores | Match Report | |
| Sat | 2021-10-16 | 19:00 | Hartford | 1–0 | Loudoun Utd | 4,908 | Dillon Stadium | Ben Meyer | Match Report | |
| Sat | 2021-10-16 | 19:00 | Indy Eleven | 1–0 | Louisville City | 6,499 | Michael A. Carroll Stadium | Ricardo Fierro | Match Report | |
| Sat | 2021-10-16 | 19:00 | Charlotte Ind'ence | 5–1 | Charleston | 3,048 | American Legion Memorial Stadium | Kyle Johnston | Match Report | |
| Sun | 2021-10-17 | 14:00 | Sac Republic | 0–0 | Tacoma | 9,983 | Papa Murphy’s Park | Brandon Stevis | Match Report | |
| Sun | 2021-10-17 | 15:00 | Loyal | 1–1 | New Mexico Utd | 4,700 | Torero Stadium | Sergii Demianchuk | Match Report | |
| Sun | 2021-10-17 | 17:00 | OKC Energy | 0–0 | B'ham Legion | 3,246 | Taft Stadium | Jeremy Scheer | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-10-16 | 18:00 | CS Switchbacks | 1–0 | RGV Toros | 8,023 | Weidner Field | Joshua Encarnacion | Match Report | |
| Sat | 2021-10-16 | 19:00 | Roots | 0–1 | Orange County | 5,039 | Laney College Field | Elijio Arreguin | Match Report | |
| Sat | 2021-10-16 | 19:30 | San Antonio | 1–1 | FC Tulsa | 5,090 | Toyota Field | Elvis Osmanovic | Match Report | |
| Sun | 2021-10-17 | 17:00 | Galaxy II | 5–0 | El Paso | Dignity Health Sports Park | Brad Jensen | Match Report | ||
| Wed | 2021-10-20 | 19:00 | NY Red Bulls II | 3–0 | Loudoun Utd | 520 | MSU Soccer Park at Pittser Field | Corbyn May | Match Report | |
| Wed | 2021-10-20 | 19:00 | Charleston | 3–1 | Galaxy II | 2,858 | Patriots Point Soccer Complex | Elton Garcia | Match Report | |
| Wed | 2021-10-20 | 19:30 | TB Rowdies | 3–0 | Miami FC | 3,976 | Al Lang Stadium | Matthew Thompson | Match Report | |
| Wed | 2021-10-20 | 19:00 | Orange County | 1–0 | Loyal | 4,910 | Orange Country Great Park Championship S... | Calin Radosav | Match Report | |
| Wed | 2021-10-20 | 19:00 | New Mexico Utd | 4–2 | San Antonio | 5,593 | Isotopes Park | Michael Radchuk | Match Report | |
| Wed | 2021-10-20 | 19:00 | FC Tulsa | 4–0 | Atlanta 2 | 2,730 | ONEOK Field | Mark Allatin | Match Report | |
| Wed | 2021-10-20 | 19:00 | Tacoma | 0–0 | Roots | 833 | Cheney Stadium | Malik Badawi | Match Report | |
| Wed | 2021-10-20 | 20:00 | El Paso | 3–0 | Bold | 5,007 | Southwest University Park | Kevin Broadley | Match Report | |
| Fri | 2021-10-22 | 19:00 | Hartford | 1–2 | Charlotte Ind'ence | 5,500 | Dillon Stadium | Thomas Snyder | Match Report | |
| Sat | 2021-10-23 | 19:00 | Pittsburgh | 2–1 | Charleston | 4,097 | Highmark Stadium | Sergii Demianchuk | Match Report | |
| Sat | 2021-10-23 | 19:00 | Loudoun Utd | 0–1 | TB Rowdies | 917 | Segra Field | Abdou Ndiaye | Match Report | |
| Fri | 2021-10-22 | 19:00 | Monarchs | 1–1 | CS Switchbacks | 1,818 | Zions Bank Stadium | John Matto | Match Report | |
| Sat | 2021-10-23 | 19:00 | Indy Eleven | 1–1 | FC Tulsa | 6,499 | Michael A. Carroll Stadium | Melvin Rivas | Match Report | |
| Sat | 2021-10-23 | 19:30 | Louisville City | 3–1 | Memphis | 10,900 | Lynn Family Stadium | Joshua Encarnacion | Match Report | |
| Sun | 2021-10-24 | 13:30 | Tacoma | 3–2 | Galaxy II | 1,475 | Cheney Stadium | Mathew Corrigan | Match Report | |
| Sun | 2021-10-24 | 15:00 | Loyal | 3–4 | Roots | Torero Stadium | Lukasz Szpala | Match Report | ||
| Sun | 2021-10-24 | 16:00 | B'ham Legion | 6–0 | Sporting KC II | BBVA Compass Field | Greg Dopka | Match Report | ||
| Sat | 2021-10-23 | 19:00 | Orange County | 2–1 | LV Lights FC | 4,996 | Orange Country Great Park Championship S... | Gerald Flores | Match Report | |
| Sat | 2021-10-23 | 19:30 | RGV Toros | 2–0 | New Mexico Utd | 4,118 | H-E-B Park | Brandon Stevis | Match Report | |
| Sun | 2021-10-24 | 19:30 | Miami FC | 2–0 | NY Red Bulls II | 715 | Riccardo Silva Stadium | Gabriele Giusti | Match Report | |
| Sat | 2021-10-23 | 19:30 | Phx Rising | 1–1 | Sac Republic | 9,236 | Casino Arizona Field | Elijio Arreguin | Match Report | |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2021-10-23 | 19:30 | San Antonio | 0–0 | Bold | 6,516 | Toyota Field | Ismir Pekmic | Match Report | |
| Sun | 2021-10-24 | 19:00 | El Paso | 4–0 | OKC Energy | 8,011 | Southwest University Park | Ben Meyer | Match Report | |
| Tue | 2021-10-26 | 19:00 | Hartford | 2–0 | Charleston | 3,480 | Dillon Stadium | Natalie Simon | Match Report | |
| Wed | 2021-10-27 | 17:30 | Charlotte Ind'ence | 1–0 | Loudoun Utd | 1,782 | American Legion Memorial Stadium | Kevin Broadley | Match Report | |
| Wed | 2021-10-27 | 19:00 | Miami FC | 0–1 | Pittsburgh | 1,083 | Riccardo Silva Stadium | Jonathan Bilinski | Match Report | |
| Wed | 2021-10-27 | 19:00 | Monarchs | 1–3 | RGV Toros | 1,688 | Zions Bank Stadium | Brad Jensen | Match Report | |
| Wed | 2021-10-27 | 19:00 | Memphis | 3–2 | FC Tulsa | 3,443 | AutoZone Park | Elton Garcia | Match Report | |
| Sat | 2021-10-30 | 13:00 | Loudoun Utd | 1–4 | NY Red Bulls II | Segra Field | Jalen Gray | Match Report | ||
| Sat | 2021-10-30 | 17:00 | New Mexico Utd | 3–1 | Monarchs | 9,570 | Isotopes Park | Elijio Arreguin | Match Report | |
| Sat | 2021-10-30 | 18:00 | Memphis | 3–0 | Indy Eleven | 4,015 | AutoZone Park | Matthew Franz | Match Report | |
| Sat | 2021-10-30 | 18:30 | B'ham Legion | 0–1 | Louisville City | BBVA Compass Field | Matthew Thompson | Match Report | ||
| Sat | 2021-10-30 | 19:00 | Pittsburgh | 0–0 | Hartford | 3,532 | Highmark Stadium | Kevin Broadley | Match Report | |
| Sat | 2021-10-30 | 19:00 | Charleston | 0–4 | Miami FC | 2,771 | Patriots Point Soccer Complex | Chris Ruska | Match Report | |
| Sat | 2021-10-30 | 19:00 | LV Lights FC | 1–2 | TB Rowdies | Cashman Field | Mark Allatin | Match Report | ||
| Sat | 2021-10-30 | 19:00 | Roots | 1–0 | Sporting KC II | 5,508 | Laney College Field | William Hoffman | Match Report | |
| Sat | 2021-10-30 | 19:30 | Sac Republic | 1–1 | Loyal | 9,931 | Papa Murphy’s Park | Thomas Snyder | Match Report | |
| Sat | 2021-10-30 | 19:30 | Galaxy II | 0–1 | Orange County | Dignity Health Sports Park | Ricardo Fierro | Match Report | ||
| Sat | 2021-10-30 | 19:30 | Phx Rising | 1–1 | Tacoma | 7,436 | Casino Arizona Field | Luis Arroyo | Match Report | |
| Sat | 2021-10-30 | 20:00 | Bold | 1–1 | Charlotte Ind'ence | 751 | Bold Stadium | Brandon Stevis | Match Report | |
| Sat | 2021-10-30 | 20:00 | FC Tulsa | 2–0 | OKC Energy | 4,053 | ONEOK Field | Michael Radchuk | Match Report | |
| Sat | 2021-10-30 | 20:30 | RGV Toros | 4–1 | El Paso | 4,440 | H-E-B Park | John Griggs | Match Report | |
| Sat | 2021-10-30 | 20:30 | San Antonio | 3–0 | CS Switchbacks | 5,232 | Toyota Field | Mathew Corrigan | Match Report |
| Round | Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Conference Quarterfinals | Sat | 2021-11-06 | 19:00 | Charlotte Ind'ence | 3–1 | Memphis | 2,723 | American Legion Memorial Stadium | Mark Allatin | Match Report | |
| Conference Quarterfinals | Sat | 2021-11-06 | 19:30 | TB Rowdies | 6–2 | FC Tulsa | 6,262 | Al Lang Stadium | Sergii Demianchuk | Match Report | |
| Conference Quarterfinals | Fri | 2021-11-05 | 20:00 | San Antonio | 2–0 | Loyal | 7,003 | Toyota Field | Matthew Thompson | Match Report | |
| Conference Quarterfinals | Fri | 2021-11-05 | 20:30 | El Paso | 0–1 | Roots | 7,201 | Southwest University Park | Ismir Pekmic | Match Report | |
| Conference Quarterfinals | Sun | 2021-11-07 | 16:00 | B'ham Legion | 3–0 | Pittsburgh | BBVA Compass Field | Match Report | Match awarded to B'ham Legion | ||
| Conference Quarterfinals | Sat | 2021-11-06 | 19:00 | Orange County | 1–0 | CS Switchbacks | 4,194 | Orange Country Great Park Championship S... | Lukasz Szpala | Match Report | |
| Conference Quarterfinals | Sat | 2021-11-06 | 19:30 | Phx Rising | (3) 3–3 (4) | RGV Toros | 8,234 | Casino Arizona Field | Brandon Stevis | Match Report | RGV Toros won on penalty kicks following extra time |
| Conference Quarterfinals | Sat | 2021-11-06 | 20:00 | Louisville City | 1–0 | Miami FC | 9,097 | Lynn Family Stadium | Elton Garcia | Match Report | |
| Conference Semifinals | Sat | 2021-11-13 | 19:00 | TB Rowdies | 1–0 | B'ham Legion | 5,949 | Al Lang Stadium | Elton Garcia | Match Report | |
| Conference Semifinals | Sat | 2021-11-13 | 19:00 | Orange County | (6) 0–0 (5) | Roots | 5,218 | Orange Country Great Park Championship S... | Matthew Thompson | Match Report | Orange County won on penalty kicks following extra time |
| Conference Semifinals | Sat | 2021-11-13 | 19:30 | Louisville City | 1–0 | Charlotte Ind'ence | 9,155 | Lynn Family Stadium | Elijio Arreguin | Match Report | |
| Conference Semifinals | Sat | 2021-11-13 | 20:00 | San Antonio | 3–1 | RGV Toros | 7,966 | Toyota Field | Mark Allatin | Match Report | |
| Conference Finals | Sat | 2021-11-20 | 19:00 | Orange County | (5) 1–1 (3) | San Antonio | 5,386 | Orange Country Great Park Championship S... | Elton Garcia | Match Report | Orange County won on penalty kicks following extra time |
| Conference Finals | Sat | 2021-11-20 | 19:30 | TB Rowdies | 3–2 | Louisville City | 7,120 | Al Lang Stadium | Lukasz Szpala | Match Report | Required Extra Time |
| Final | Sun | 2021-11-28 | 20:30 | TB Rowdies | 1–3 | Orange County | 7,521 | Al Lang Stadium | Rubiel Vazquez | Match Report |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
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