Scores & Fixtures 2021-2022 Ligue 2
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular season | 1 | Sat | 2021-07-24 | 15:00 | Bastia | 0.9 | 1–1 | 0.6 | Nîmes | 8,165 | Stade Armand Césari | Jérôme Miguelgorry | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Dunkerque | 0.8 | 1–1 | 1.1 | Quevilly-Rouen | 1,500 | Stade Marcel-Tribut | Olivier Thual | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Grenoble | 0.3 | 0–4 | 1.7 | Paris FC | 536 | Stade Jean Laville | Pierre Gaillouste | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Pau FC | 1.8 | 2–1 | 0.9 | Nancy | 1,803 | Stade Nouste Camp | Marc Bollengier | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Amiens | 1.2 | 1–2 | 1.4 | Auxerre | 5,562 | Stade Crédit Agricole la Licorne | Mathieu Vernice | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Valenciennes | 0.8 | 0–0 | 0.7 | Niort | 3,561 | Stade du Hainaut | Arnaud Baert | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Le Havre | 1.6 | 0–0 | 1.2 | Guingamp | 3,661 | Stade Océane | Remi Landry | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Toulouse | 1.1 | 2–2 | 0.4 | Ajaccio | 4,925 | Stadium Municipal | Franck Schneider | Match Report | |
| Regular season | 1 | Sat | 2021-07-24 | 19:00 | Caen | 2.1 | 4–0 | 1.5 | Rodez Aveyron | 7,292 | Stade Michel d'Ornano | Guillaume Paradis | Match Report | |
| Regular season | 1 | Mon | 2021-07-26 | 20:45 | Dijon | 0.7 | 1–3 | 2.2 | Sochaux | 7,641 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 15:00 | Nîmes | 2.6 | 2–1 | 0.8 | Dijon | 2,375 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Sochaux | 1.2 | 0–2 | 1.4 | Le Havre | 4,204 | Stade Gaston Gérard | Gaël Angoula | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Guingamp | 1.2 | 1–1 | 0.8 | Valenciennes | 6,291 | Stade du Roudourou | Mathieu Vernice | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Ajaccio | 0.9 | 3–1 | 1.5 | Amiens | 2,491 | Stade François Coty | Nicolas Rainville | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Rodez Aveyron | 0.4 | 1–0 | 0.3 | Pau FC | 1,346 | Stade Paul Lignon | Remi Landry | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Nancy | 0.7 | 0–4 | 2.3 | Toulouse | 5,678 | Stade Marcel Picot | Alexandre Perreau Niel | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Paris FC | 1.3 | 2–1 | 0.5 | Dunkerque | 2,148 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| Regular season | 2 | Sat | 2021-07-31 | 19:00 | Niort | 0.3 | 0–1 | 0.6 | Caen | 1,523 | Stade René Gaillard | Abdelatif Kherradji | Match Report | |
| Regular season | 2 | Mon | 2021-08-02 | 20:45 | Auxerre | 2.1 | 3–0 | 0.6 | Grenoble | 4,660 | Stade de l'Abbé Deschamps | Romain Lissorgue | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 15:00 | Caen | 0.7 | 1–2 | 1.7 | Sochaux | 9,177 | Stade Michel d'Ornano | Franck Schneider | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Auxerre | 0.8 | 0–0 | 0.5 | Ajaccio | 4,942 | Stade de l'Abbé Deschamps | Olivier Thual | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Grenoble | 0.6 | 0–0 | 0.8 | Guingamp | 309 | Stade Jean Laville | Jérôme Miguelgorry | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Pau FC | 0.9 | 0–1 | 0.4 | Toulouse | 3,342 | Stade Nouste Camp | Aurélien Petit | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Le Havre | 1.3 | 1–2 | 1.0 | Paris FC | 4,662 | Stade Océane | Arnaud Baert | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Dijon | 0.4 | 1–1 | 0.8 | Rodez Aveyron | 6,004 | Stade Gaston Gérard | Ruddy Buquet | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Amiens | 0.8 | 1–3 | 2.1 | Quevilly-Rouen | 5,584 | Stade Crédit Agricole la Licorne | Marc Bollengier | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Dunkerque | 0.6 | 1–2 | 0.6 | Niort | 1,584 | Stade Marcel-Tribut | Benjamin Lepaysant | Match Report | |
| Regular season | 3 | Sat | 2021-08-07 | 19:00 | Valenciennes | 0.8 | 0–3 | 0.7 | Nîmes | 4,074 | Stade du Hainaut | Bartolomeu Varela | Match Report | |
| Regular season | 3 | Wed | 2021-08-11 | 19:00 | Bastia | 0.7 | 1–1 | 1.4 | Nancy | 10,025 | Stade Armand Césari | Pierre Gaillouste | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 15:00 | Toulouse | 1.5 | 1–0 | 0.3 | Bastia | 6,249 | Stadium Municipal | Antony Gautier | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Quevilly-Rouen | 2.6 | 2–1 | 1.1 | Dijon | 816 | Stade Michel d'Ornano | Gaël Angoula | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Guingamp | 0.9 | 0–2 | 1.2 | Amiens | 6,518 | Stade du Roudourou | Alexandre Perreau Niel | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Niort | 0.6 | 1–0 | 2.2 | Grenoble | 1,329 | Stade René Gaillard | Guillaume Paradis | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Nîmes | 1.5 | 0–0 | 1.3 | Pau FC | 1,849 | Stade des Costières | Mathieu Vernice | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Sochaux | 1.9 | 1–0 | 1.3 | Dunkerque | 6,388 | Stade Auguste-Bonal | Bartolomeu Varela | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Rodez Aveyron | 0.8 | 0–0 | 1.0 | Le Havre | 1,496 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| Regular season | 4 | Sat | 2021-08-14 | 19:00 | Nancy | 0.6 | 0–1 | 2.3 | Valenciennes | 5,725 | Stade Marcel Picot | Pierre Legat | Match Report | |
| Regular season | 4 | Mon | 2021-08-16 | 20:45 | Paris FC | 1.2 | 1–1 | 1.5 | Auxerre | 3,253 | Stade Sébastien Charléty | Nicolas Rainville | Match Report | |
| Regular season | 2 | Wed | 2021-08-18 | 19:00 | Quevilly-Rouen | 1.4 | 1–2 | 1.3 | Bastia | 895 | Stade Michel d'Ornano | Pierre Legat | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 15:00 | Dijon | 1.6 | 2–4 | 2.3 | Toulouse | 6,756 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Amiens | 0.3 | 0–0 | 1.5 | Sochaux | 5,982 | Stade Moulonguet | Jérôme Miguelgorry | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Le Havre | 1.6 | 2–1 | 1.3 | Niort | 4,394 | Stade Municipal Jules Deschaseaux | Marc Bollengier | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Pau FC | 1.5 | 2–0 | 1.3 | Bastia | 2,600 | Stade Nouste Camp | Arnaud Baert | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Valenciennes | 1.3 | 1–4 | 0.8 | Rodez Aveyron | 4,366 | Stade Nungesser | Benjamin Lepaysant | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Dunkerque | 0.6 | 0–2 | 1.0 | Nîmes | 1,498 | Stade Marcel-Tribut | Alexandre Perreau Niel | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Caen | 1.2 | 1–0 | 0.7 | Nancy | 8,855 | Stade Michel d'Ornano | Olivier Thual | Match Report | |
| Regular season | 5 | Sat | 2021-08-21 | 19:00 | Grenoble | 2.3 | 2–0 | 0.5 | Quevilly-Rouen | 3,630 | Stade Lesdiguières | Franck Schneider | Match Report | |
| Regular season | 5 | Mon | 2021-08-23 | 20:45 | Auxerre | 1.2 | 1–2 | 1.5 | Guingamp | 6,516 | Stade de l'Abbé Deschamps | Aurélien Petit | Match Report | |
| Regular season | 4 | Wed | 2021-08-25 | 19:00 | Ajaccio | 2.2 | 2–0 | 0.5 | Caen | 2,830 | Stade François Coty | Remi Landry | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 15:00 | Nîmes | 0.7 | 0–0 | 0.8 | Caen | 3,296 | Stade des Costières | Florent Batta | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 15:00 | Toulouse | 1.1 | 1–0 | 0.6 | Valenciennes | 7,614 | Stadium Municipal | Mathieu Vernice | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Sochaux | 0.8 | 1–0 | 0.3 | Grenoble | 7,367 | Stade Auguste-Bonal | Olivier Thual | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Rodez Aveyron | 1.1 | 2–2 | 0.8 | Dunkerque | 1,393 | Stade Paul Lignon | Pierre Legat | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Niort | 1.6 | 0–0 | 0.3 | Amiens | 1,598 | Stade René Gaillard | Bartolomeu Varela | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Quevilly-Rouen | 0.4 | 0–1 | 2.5 | Paris FC | 2,789 | Stade Robert Diochon | Remi Landry | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Nancy | 2.5 | 1–4 | 2.7 | Auxerre | 5,977 | Stade Marcel Picot | Gaël Angoula | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Bastia | 1.6 | 0–0 | 0.3 | Le Havre | 8,742 | Stade Armand Césari | Aurélien Petit | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Guingamp | 0.6 | 1–1 | 1.4 | Ajaccio | 6,200 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| Regular season | 6 | Sat | 2021-08-28 | 19:00 | Pau FC | 1.6 | 2–0 | 0.8 | Dijon | 2,263 | Stade Nouste Camp | Abdelatif Kherradji | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 15:00 | Paris FC | 1.8 | 0–1 | 1.0 | Guingamp | 3,298 | Stade Sébastien Charléty | Marc Bollengier | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Dunkerque | 1.1 | 0–0 | 1.1 | Nancy | 1,950 | Stade Marcel-Tribut | Benjamin Lepaysant | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Valenciennes | 0.8 | 1–2 | 1.6 | Quevilly-Rouen | 5,666 | Stade du Hainaut | Arnaud Baert | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Caen | 1.7 | 1–2 | 1.2 | Pau FC | 8,867 | Stade Michel d'Ornano | Alexandre Perreau Niel | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Auxerre | 1.7 | 4–0 | 0.8 | Niort | 7,802 | Stade de l'Abbé Deschamps | Abdelatif Kherradji | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Grenoble | 1.5 | 2–1 | 0.8 | Nîmes | 5,274 | Stade des Alpes | Bastien Dechepy | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Ajaccio | 0.7 | 1–0 | 0.7 | Sochaux | 2,474 | Stade François Coty | Franck Schneider | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Dijon | 0.6 | 2–1 | 2.1 | Bastia | 7,249 | Stade Gaston Gérard | Bartolomeu Varela | Match Report | |
| Regular season | 7 | Sat | 2021-09-11 | 19:00 | Amiens | 1.0 | 0–1 | 1.1 | Rodez Aveyron | 5,853 | Stade Crédit Agricole la Licorne | Nicolas Rainville | Match Report | |
| Regular season | 7 | Mon | 2021-09-13 | 20:45 | Le Havre | 0.9 | 1–1 | 1.0 | Toulouse | 5,998 | Stade Océane | Gaël Angoula | Match Report | |
| Regular season | 5 | Tue | 2021-09-14 | 19:00 | Ajaccio | 0.9 | 1–0 | 1.3 | Paris FC | 2,573 | Stade François Coty | Jeremy Stinat | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 15:00 | Sochaux | 1.2 | 2–0 | 0.6 | Paris FC | 7,948 | Stade Auguste-Bonal | Jérémie Pignard | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 15:00 | Toulouse | 3.3 | 4–1 | 0.3 | Grenoble | 8,969 | Stadium Municipal | Alexandre Perreau Niel | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Quevilly-Rouen | 0.8 | 0–0 | 1.0 | Auxerre | 3,549 | Stade Robert Diochon | Olivier Thual | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Nancy | 1.9 | 1–1 | 0.5 | Le Havre | 6,649 | Stade Marcel Picot | Franck Schneider | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Pau FC | 1.5 | 1–1 | 1.6 | Valenciennes | 2,735 | Stade Nouste Camp | Pierre Legat | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Nîmes | 1.4 | 3–3 | 2.8 | Amiens | 2,497 | Stade des Costières | Remi Landry | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Dijon | 1.8 | 2–0 | 0.7 | Dunkerque | 7,000 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Rodez Aveyron | 0.6 | 0–2 | 0.8 | Ajaccio | 1,576 | Stade Paul Lignon | Gaël Angoula | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Bastia | 1.1 | 1–1 | 1.2 | Caen | 7,682 | Stade Armand Césari | Guillaume Paradis | Match Report | |
| Regular season | 8 | Sat | 2021-09-18 | 19:00 | Niort | 1.0 | 2–0 | 0.7 | Guingamp | 1,846 | Stade René Gaillard | Mathieu Vernice | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Valenciennes | 1.7 | 2–1 | 1.0 | Bastia | 4,638 | Stade du Hainaut | Alexandre Perreau Niel | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Le Havre | 1.9 | 1–0 | 0.6 | Quevilly-Rouen | 7,650 | Stade Océane | Mathieu Vernice | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Guingamp | 1.4 | 1–2 | 1.1 | Sochaux | 7,088 | Stade du Roudourou | Nicolas Rainville | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Ajaccio | 1.1 | 0–0 | 0.6 | Niort | 2,622 | Stade François Coty | Benjamin Lepaysant | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Auxerre | 1.0 | 1–0 | 0.5 | Rodez Aveyron | 7,445 | Stade de l'Abbé Deschamps | Bartolomeu Varela | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Amiens | 0.5 | 2–2 | 2.5 | Pau FC | 5,715 | Stade Crédit Agricole la Licorne | Marc Bollengier | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Grenoble | 2.2 | 4–1 | 1.5 | Nancy | 3,845 | Stade des Alpes | Pierre Legat | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Caen | 1.6 | 0–1 | 0.6 | Dijon | 8,391 | Stade Michel d'Ornano | Gaël Angoula | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Paris FC | 1.9 | 2–0 | 0.8 | Nîmes | 2,726 | Stade Sébastien Charléty | Pierre Gaillouste | Match Report | |
| Regular season | 9 | Tue | 2021-09-21 | 20:00 | Dunkerque | 0.6 | 0–2 | 1.8 | Toulouse | 1,752 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Quevilly-Rouen | 1.4 | 2–2 | 1.2 | Guingamp | 3,513 | Stade Robert Diochon | Guillaume Paradis | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Rodez Aveyron | 1.3 | 1–1 | 0.8 | Grenoble | 1,285 | Stade Paul Lignon | Jérôme Miguelgorry | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Sochaux | 0.8 | 0–0 | 0.3 | Auxerre | 9,185 | Stade Auguste-Bonal | Remi Landry | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Pau FC | 3.0 | 1–2 | 0.6 | Dunkerque | 2,092 | Stade Nouste Camp | Mathieu Vernice | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Dijon | 2.3 | 0–1 | 0.3 | Valenciennes | 7,118 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Nîmes | 0.6 | 0–1 | 0.8 | Le Havre | 2,540 | Stade des Costières | Aurélien Petit | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Niort | 0.7 | 4–1 | 3.0 | Paris FC | 1,802 | Stade René Gaillard | Nicolas Rainville | Match Report | |
| Regular season | 10 | Fri | 2021-09-24 | 21:00 | Nancy | 1.1 | 1–1 | 0.4 | Amiens | 6,010 | Stade Marcel Picot | Olivier Thual | Match Report | |
| Regular season | 10 | Sat | 2021-09-25 | 15:00 | Bastia | 1.1 | 2–0 | 0.4 | Ajaccio | 11,686 | Stade Armand Césari | Florent Batta | Match Report | |
| Regular season | 10 | Mon | 2021-09-27 | 20:45 | Toulouse | 2.1 | 2–3 | 1.6 | Caen | 9,856 | Stadium Municipal | Bartolomeu Varela | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 15:00 | Auxerre | 0.9 | 2–2 | 1.6 | Nîmes | 9,479 | Stade de l'Abbé Deschamps | Romain Lissorgue | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 15:00 | Amiens | 0.4 | 0–0 | 1.1 | Toulouse | 11,733 | Stade Crédit Agricole la Licorne | Mathieu Vernice | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Caen | 1.5 | 1–2 | 2.2 | Valenciennes | 8,490 | Stade Michel d'Ornano | Abdelatif Kherradji | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Dunkerque | 0.8 | 2–0 | 0.9 | Bastia | 2,150 | Stade Marcel-Tribut | Remi Landry | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Guingamp | 1.1 | 2–1 | 1.1 | Rodez Aveyron | 6,756 | Stade du Roudourou | Pierre Legat | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Sochaux | 1.4 | 1–0 | 0.4 | Niort | 10,678 | Stade Auguste-Bonal | Aurélien Petit | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Le Havre | 1.5 | 2–0 | 1.5 | Dijon | 5,096 | Stade Océane | Marc Bollengier | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Ajaccio | 0.7 | 0–1 | 0.4 | Quevilly-Rouen | 2,497 | Stade François Coty | Alexandre Perreau Niel | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Paris FC | 1.1 | 1–1 | 1.3 | Nancy | 2,710 | Stade Sébastien Charléty | Gaël Angoula | Match Report | |
| Regular season | 11 | Sat | 2021-10-02 | 19:00 | Grenoble | 1.2 | 2–0 | 0.7 | Pau FC | 4,427 | Stade des Alpes | Benjamin Lepaysant | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 15:00 | Toulouse | 1.9 | 6–0 | 0.3 | Auxerre | 10,302 | Stadium Municipal | Franck Schneider | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Pau FC | 1.6 | 1–0 | 0.8 | Paris FC | 2,854 | Stade Nouste Camp | Arnaud Baert | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Rodez Aveyron | 0.5 | 0–1 | 0.4 | Sochaux | 1,541 | Stade Paul Lignon | Olivier Thual | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Valenciennes | 2.5 | 1–3 | 1.7 | Dunkerque | 10,429 | Stade du Hainaut | Benjamin Lepaysant | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Caen | 1.1 | 2–2 | 1.0 | Le Havre | 16,729 | Stade Michel d'Ornano | Hakim Ben El Hadj Salem | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Bastia | 1.1 | 0–0 | 0.8 | Grenoble | 8,303 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Nancy | 1.6 | 2–1 | 1.0 | Guingamp | 5,000 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Quevilly-Rouen | 0.2 | 0–3 | 1.8 | Niort | 3,300 | Stade Robert Diochon | Bartolomeu Varela | Match Report | |
| Regular season | 12 | Sat | 2021-10-16 | 19:00 | Dijon | 0.5 | 1–0 | 1.1 | Amiens | 7,445 | Stade Gaston Gérard | Jérôme Miguelgorry | Match Report | |
| Regular season | 12 | Mon | 2021-10-18 | 20:45 | Nîmes | 0.7 | 0–2 | 1.9 | Ajaccio | 2,329 | Stade des Costières | Guillaume Paradis | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 15:00 | Paris FC | 1.1 | 2–2 | 2.0 | Toulouse | 4,068 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Guingamp | 2.0 | 3–1 | 1.3 | Nîmes | 9,983 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Le Havre | 0.9 | 1–0 | 0.7 | Pau FC | 5,439 | Stade Municipal Jules Deschaseaux | Abdelatif Kherradji | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Amiens | 1.0 | 3–0 | 1.6 | Valenciennes | 8,781 | Stade Moulonguet | Bartolomeu Varela | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Grenoble | 0.2 | 1–2 | 2.3 | Dijon | 5,714 | Stade Lesdiguières | Gaël Angoula | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Sochaux | 1.5 | 1–1 | 0.6 | Quevilly-Rouen | 9,081 | Stade Auguste-Bonal | Jeremy Stinat | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Niort | 0.9 | 0–2 | 1.0 | Rodez Aveyron | 2,439 | Stade René Gaillard | Alexandre Perreau Niel | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Ajaccio | 1.9 | 2–0 | 0.5 | Nancy | 2,713 | Stade François Coty | Mathieu Vernice | Match Report | |
| Regular season | 13 | Sat | 2021-10-23 | 19:00 | Dunkerque | 1.2 | 1–1 | 1.1 | Caen | 2,500 | Stade Marcel-Tribut | Aurélien Petit | Match Report | |
| Regular season | 13 | Mon | 2021-10-25 | 20:45 | Auxerre | 0.3 | 1–0 | 0.7 | Bastia | 8,559 | Stade de l'Abbé Deschamps | Pierre Legat | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 15:00 | Toulouse | 1.1 | 2–2 | 1.5 | Guingamp | 10,491 | Stadium Municipal | Nicolas Rainville | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Caen | 0.6 | 0–1 | 1.9 | Grenoble | 8,651 | Stade Michel d'Ornano | Arnaud Baert | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Pau FC | 0.7 | 1–0 | 0.6 | Ajaccio | 2,691 | Stade Nouste Camp | Marc Bollengier | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Bastia | 1.2 | 0–0 | 1.1 | Amiens | 8,018 | Stade Armand Césari | Thomas Léonard | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Nîmes | 0.8 | 1–2 | 1.8 | Niort | 1,174 | Stade des Costières | Olivier Thual | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Rodez Aveyron | 1.1 | 3–0 | 0.8 | Quevilly-Rouen | 1,521 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Dunkerque | 1.2 | 1–0 | 0.6 | Le Havre | 2,200 | Stade Marcel-Tribut | Pierre Legat | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Nancy | 1.1 | 0–0 | 0.8 | Sochaux | 8,114 | Stade Marcel Picot | Benjamin Lepaysant | Match Report | |
| Regular season | 14 | Sat | 2021-10-30 | 19:00 | Dijon | 2.4 | 0–1 | 0.8 | Paris FC | 7,660 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| Regular season | 14 | Mon | 2021-11-01 | 20:45 | Valenciennes | 0.7 | 1–2 | 1.7 | Auxerre | 6,574 | Stade Nungesser | Aurélien Petit | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 15:00 | Sochaux | 1.6 | 0–1 | 1.3 | Nîmes | 9,780 | Stade Auguste-Bonal | Bastien Dechepy | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 15:00 | Auxerre | 2.0 | 4–1 | 1.0 | Pau FC | 10,308 | Stade de l'Abbé Deschamps | Guillaume Paradis | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Niort | 1.9 | 1–3 | 2.0 | Nancy | 2,050 | Stade René Gaillard | Jérôme Miguelgorry | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Ajaccio | 2.0 | 1–0 | 0.2 | Dijon | 2,532 | Stade François Coty | Bartolomeu Varela | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Paris FC | 1.2 | 1–0 | 0.6 | Rodez Aveyron | 2,477 | Stade Sébastien Charléty | Mathieu Vernice | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Le Havre | 0.7 | 0–0 | 0.2 | Valenciennes | 5,504 | Stade Océane | Arnaud Baert | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Grenoble | 1.5 | 1–0 | 0.1 | Dunkerque | 4,171 | Stade des Alpes | Franck Schneider | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Amiens | 0.3 | 0–0 | 0.5 | Caen | 8,790 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Quevilly-Rouen | 0.4 | 0–0 | 1.7 | Toulouse | 4,079 | Stade Robert Diochon | Gaël Angoula | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 19:00 | Guingamp | 1.1 | 2–3 | 1.2 | Bastia | 8,769 | Stade du Roudourou | Benjamin Lepaysant | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 15:00 | Toulouse | 1.5 | 4–1 | 1.1 | Sochaux | 15,069 | Stadium Municipal | Olivier Thual | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Caen | 1.1 | 0–1 | 1.4 | Paris FC | 11,635 | Stade Michel d'Ornano | Marc Bollengier | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Valenciennes | 1.8 | 1–0 | 0.3 | Grenoble | 4,927 | Stade Nungesser | Gaël Angoula | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Nîmes | 1.3 | 2–1 | 1.8 | Quevilly-Rouen | 1,203 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Dunkerque | 0.8 | 0–1 | 0.7 | Ajaccio | 2,084 | Stade Marcel-Tribut | Arnaud Baert | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Nancy | 1.3 | 0–2 | 1.8 | Rodez Aveyron | 8,680 | Stade Marcel Picot | Pierre Legat | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Bastia | 1.6 | 2–0 | 1.4 | Niort | 7,728 | Stade Armand Césari | Johan Hamel | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Pau FC | 2.2 | 2–0 | 1.8 | Guingamp | 2,443 | Stade Nouste Camp | Franck Schneider | Match Report | |
| Regular season | 16 | Sat | 2021-11-20 | 19:00 | Le Havre | 1.1 | 1–1 | 2.2 | Amiens | 5,120 | Stade Municipal Jules Deschaseaux | Jérôme Miguelgorry | Match Report | |
| Regular season | 16 | Mon | 2021-11-22 | 20:45 | Dijon | 2.5 | 3–1 | 1.2 | Auxerre | 11,301 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Paris FC | 2.0 | 1–0 | 0.4 | Bastia | 2,764 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Ajaccio | 1.4 | 0–0 | 0.1 | Valenciennes | 3,197 | Stade François Coty | Pierre Legat | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Grenoble | 0.8 | 1–2 | 1.5 | Le Havre | 4,085 | Stade Lesdiguières | Marc Bollengier | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Quevilly-Rouen | 1.0 | 2–1 | 1.3 | Nancy | 2,912 | Stade Robert Diochon | Bartolomeu Varela | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Rodez Aveyron | 1.5 | 1–0 | 0.7 | Nîmes | 1,567 | Stade Paul Lignon | Guillaume Paradis | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Amiens | 3.5 | 3–0 | 0.4 | Dunkerque | 7,626 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Sochaux | 1.4 | 2–1 | 0.4 | Pau FC | 7,049 | Stade Auguste-Bonal | Nicolas Rainville | Match Report | |
| Regular season | 17 | Fri | 2021-12-03 | 21:00 | Guingamp | 1.3 | 3–2 | 1.0 | Dijon | 7,388 | Stade du Roudourou | Aurélien Petit | Match Report | |
| Regular season | 17 | Sat | 2021-12-04 | 15:00 | Auxerre | 1.2 | 2–2 | 1.2 | Caen | 6,366 | Stade de l'Abbé Deschamps | Jérôme Miguelgorry | Match Report | |
| Regular season | 17 | Mon | 2021-12-06 | 20:45 | Niort | 1.2 | 2–1 | 2.3 | Toulouse | 2,370 | Stade René Gaillard | Eric Wattellier | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 15:00 | Le Havre | 1.2 | 0–1 | 0.6 | Ajaccio | 7,400 | Stade Municipal Jules Deschaseaux | Jérôme Brisard | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Nîmes | 2.2 | 2–1 | 1.7 | Nancy | 1,210 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Amiens | 2.0 | 4–1 | 0.6 | Grenoble | 7,853 | Stade Moulonguet | Franck Schneider | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Dijon | 0.9 | 2–2 | 1.2 | Niort | 6,820 | Stade Gaston Gérard | Abdelatif Kherradji | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Valenciennes | 1.1 | 1–4 | 3.1 | Paris FC | 7,572 | Stade Nungesser | Arnaud Baert | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Pau FC | 1.5 | 1–2 | 1.0 | Quevilly-Rouen | 2,171 | Stade Nouste Camp | Gaël Angoula | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Bastia | 1.5 | 2–2 | 1.9 | Sochaux | 7,611 | Stade Armand Césari | Aurélien Petit | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Dunkerque | 0.1 | 0–2 | 1.9 | Auxerre | 1,925 | Stade Marcel-Tribut | Guillaume Paradis | Match Report | |
| Regular season | 18 | Sat | 2021-12-11 | 19:00 | Caen | 2.4 | 2–0 | 0.8 | Guingamp | 9,834 | Stade Michel d'Ornano | Mathieu Vernice | Match Report | |
| Regular season | 18 | Mon | 2021-12-13 | 20:45 | Toulouse | 1.2 | 1–1 | 0.3 | Rodez Aveyron | 11,577 | Stadium Municipal | Nicolas Rainville | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Quevilly-Rouen | 1.5 | 2–2 | 1.0 | Caen | 5,058 | Stade Michel d'Ornano | Alexandre Perreau Niel | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Niort | 1.6 | 3–0 | 0.4 | Pau FC | 2,173 | Stade René Gaillard | Aurélien Petit | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Nancy | 1.0 | 0–3 | 1.6 | Dijon | 138 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Nîmes | 1.2 | 1–2 | 1.3 | Toulouse | 2,064 | Stade des Costières | Willy Delajod | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Guingamp | 1.9 | 2–1 | 0.5 | Dunkerque | 7,277 | Stade du Roudourou | Olivier Thual | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Ajaccio | 0.8 | 1–0 | 0.3 | Grenoble | 3,472 | Stade François Coty | Arnaud Baert | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Sochaux | 1.1 | 1–1 | 1.0 | Valenciennes | 7,221 | Stade Auguste-Bonal | Abdelatif Kherradji | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Auxerre | 1.7 | 2–3 | 1.2 | Le Havre | 6,985 | Stade de l'Abbé Deschamps | Pierre Legat | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Paris FC | 0.3 | 1–0 | 1.0 | Amiens | 2,596 | Stade Sébastien Charléty | Gaël Angoula | Match Report | |
| Regular season | 19 | Tue | 2021-12-21 | 20:45 | Rodez Aveyron | 0.5 | 0–0 | 0.5 | Bastia | 1,567 | Stade Paul Lignon | Franck Schneider | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 15:00 | Le Havre | 0.7 | 0–1 | 0.8 | Sochaux | 4,998 | Stade Océane | Marc Bollengier | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 19:00 | Pau FC | 2.4 | 4–0 | 0.7 | Rodez Aveyron | 2,162 | Stade Nouste Camp | Bartolomeu Varela | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 19:00 | Grenoble | 0.6 | 0–1 | 0.9 | Auxerre | 3,881 | Stade Lesdiguières | Benjamin Lepaysant | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 19:00 | Dijon | 1.6 | 1–2 | 1.4 | Nîmes | 5,400 | Stade Gaston Gérard | Mathieu Vernice | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 19:00 | Bastia | 2.1 | 3–0 | 0.4 | Quevilly-Rouen | 5,000 | Stade Armand Césari | Ruddy Buquet | Match Report | |
| Regular season | 20 | Sat | 2022-01-08 | 19:00 | Valenciennes | 0.5 | 1–1 | 1.6 | Guingamp | 4,146 | Stade Nungesser | Gaël Angoula | Match Report | |
| Regular season | 21 | Sat | 2022-01-15 | 19:00 | Rodez Aveyron | 1.5 | 0–2 | 1.5 | Dijon | 1,165 | Stade Paul Lignon | Nicolas Rainville | Match Report | |
| Regular season | 21 | Sat | 2022-01-15 | 19:00 | Nancy | 1.3 | 2–1 | 1.1 | Bastia | 4,983 | Stade Marcel Picot | Jérôme Miguelgorry | Match Report | |
| Regular season | 21 | Sat | 2022-01-15 | 19:00 | Toulouse | 2.1 | 1–1 | 0.5 | Pau FC | 5,281 | Stadium Municipal | Franck Schneider | Match Report | |
| Regular season | 21 | Sat | 2022-01-15 | 19:00 | Guingamp | 1.0 | 0–0 | 0.5 | Grenoble | 2,699 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| Regular season | 21 | Sat | 2022-01-15 | 20:00 | Sochaux | 2.3 | 3–2 | 1.2 | Caen | 5,000 | Stade Auguste-Bonal | Aurélien Petit | Match Report | |
| Regular season | 21 | Mon | 2022-01-17 | 20:45 | Paris FC | 1.3 | 2–2 | 1.3 | Le Havre | 910 | Stade Sébastien Charléty | Bartolomeu Varela | Match Report | |
| Regular season | 20 | Wed | 2022-01-19 | 19:00 | Amiens | 1.3 | 0–1 | 0.7 | Ajaccio | 2,500 | Stade Moulonguet | Guillaume Paradis | Match Report | |
| Regular season | 20 | Wed | 2022-01-19 | 19:00 | Toulouse | 1.9 | 4–0 | 0.4 | Nancy | 5,482 | Stadium Municipal | Olivier Thual | Match Report | |
| Regular season | 22 | Sat | 2022-01-22 | 19:00 | Amiens | 1.0 | 3–0 | 2.1 | Guingamp | 4,000 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| Regular season | 22 | Sat | 2022-01-22 | 19:00 | Le Havre | 0.9 | 0–0 | 0.2 | Rodez Aveyron | 4,045 | Stade Océane | Abdelatif Kherradji | Match Report | |
| Regular season | 22 | Sat | 2022-01-22 | 19:00 | Bastia | 0.3 | 0–0 | 1.0 | Toulouse | 5,000 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| Regular season | 22 | Sat | 2022-01-22 | 19:00 | Dunkerque | 0.2 | 0–0 | 1.4 | Sochaux | 2,300 | Stade Marcel-Tribut | Arnaud Baert | Match Report | |
| Regular season | 22 | Sat | 2022-01-22 | 19:00 | Dijon | 2.1 | 1–0 | 0.5 | Quevilly-Rouen | 3,093 | Stade Gaston Gérard | Bartolomeu Varela | Match Report | |
| Regular season | 22 | Mon | 2022-01-24 | 20:45 | Caen | 1.3 | 2–0 | 0.3 | Ajaccio | 5,000 | Stade Michel d'Ornano | Jeremy Stinat | Match Report | |
| Regular season | 21 | Wed | 2022-01-26 | 19:00 | Quevilly-Rouen | 0.8 | 1–1 | 1.0 | Amiens | 2,200 | Stade Robert Diochon | Abdelatif Kherradji | Match Report | |
| Regular season | 20 | Fri | 2022-01-28 | 19:00 | Caen | 1.5 | 0–2 | 0.9 | Niort | 3,000 | Stade Michel d'Ornano | Arnaud Baert | Match Report | |
| Regular season | 20 | Fri | 2022-01-28 | 19:00 | Dunkerque | 1.2 | 1–1 | 1.9 | Paris FC | 2,300 | Stade Marcel-Tribut | Nicolas Rainville | Match Report | |
| Regular season | 21 | Fri | 2022-01-28 | 19:00 | Ajaccio | 1.7 | 0–0 | 0.5 | Auxerre | 3,300 | Stade François Coty | Mathieu Vernice | Match Report | |
| Regular season | 21 | Fri | 2022-01-28 | 19:00 | Nîmes | 2.5 | 2–1 | 1.6 | Valenciennes | 1,378 | Stade des Costières | Romain Lissorgue | Match Report | |
| Regular season | 21 | Tue | 2022-02-01 | 19:00 | Niort | 1.1 | 2–0 | 0.6 | Dunkerque | 1,614 | Stade René Gaillard | Jérôme Miguelgorry | Match Report | |
| Regular season | 22 | Tue | 2022-02-01 | 19:00 | Auxerre | 2.7 | 1–2 | 2.2 | Paris FC | 4,331 | Stade de l'Abbé Deschamps | Gaël Angoula | Match Report | |
| Regular season | 22 | Tue | 2022-02-01 | 19:00 | Valenciennes | 3.9 | 6–1 | 1.1 | Nancy | 3,830 | Stade Nungesser | Mathieu Vernice | Match Report | |
| Regular season | 22 | Tue | 2022-02-01 | 19:00 | Pau FC | 1.3 | 0–3 | 2.4 | Nîmes | 2,224 | Stade Nouste Camp | Remi Landry | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 15:00 | Toulouse | 2.5 | 4–1 | 1.1 | Dijon | 11,000 | Stadium Municipal | Marc Bollengier | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Nîmes | 0.5 | 0–1 | 1.1 | Dunkerque | 1,500 | Stade des Costières | Pierre Legat | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Niort | 0.4 | 0–0 | 0.7 | Le Havre | 2,021 | Stade René Gaillard | Aurélien Petit | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Nancy | 1.7 | 1–1 | 1.3 | Caen | 4,000 | Stade Marcel Picot | Remi Landry | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Sochaux | 1.6 | 1–1 | 0.5 | Amiens | 6,623 | Stade Auguste-Bonal | Franck Schneider | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Guingamp | 1.1 | 1–1 | 1.0 | Auxerre | 7,422 | Stade du Roudourou | Abdelatif Kherradji | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Rodez Aveyron | 0.8 | 0–0 | 0.6 | Valenciennes | 1,198 | Stade Paul Lignon | Olivier Thual | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Quevilly-Rouen | 0.7 | 1–0 | 0.5 | Grenoble | 2,400 | Stade Robert Diochon | Arnaud Baert | Match Report | |
| Regular season | 23 | Sat | 2022-02-05 | 19:00 | Bastia | 1.8 | 1–1 | 0.7 | Pau FC | 7,500 | Stade Armand Césari | Guillaume Paradis | Match Report | |
| Regular season | 23 | Mon | 2022-02-07 | 20:45 | Paris FC | 1.5 | 2–0 | 0.8 | Ajaccio | 900 | Stade Sébastien Charléty | Hakim Ben El Hadj Salem | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 15:00 | Valenciennes | 0.3 | 1–3 | 2.6 | Toulouse | 5,303 | Stade du Hainaut | Bartolomeu Varela | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Paris FC | 2.5 | 3–0 | 0.4 | Quevilly-Rouen | Stade Sébastien Charléty | Benjamin Lepaysant | Match Report | ||
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Grenoble | 1.4 | 1–3 | 1.9 | Sochaux | 4,001 | Stade des Alpes | Abdelatif Kherradji | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Auxerre | 1.4 | 1–1 | 1.5 | Nancy | 5,003 | Stade de l'Abbé Deschamps | Marc Bollengier | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Amiens | 1.3 | 3–1 | 1.7 | Niort | 7,182 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Ajaccio | 0.1 | 0–1 | 0.5 | Guingamp | 3,200 | Stade François Coty | Pierre Legat | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Dijon | 1.1 | 0–1 | 0.8 | Pau FC | 6,465 | Stade Gaston Gérard | Gaël Angoula | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Caen | 4.4 | 4–0 | 0.5 | Nîmes | 8,075 | Stade Michel d'Ornano | Olivier Thual | Match Report | |
| Regular season | 24 | Sat | 2022-02-12 | 19:00 | Dunkerque | 0.8 | 2–0 | 0.6 | Rodez Aveyron | 2,200 | Stade Marcel-Tribut | Hakim Ben El Hadj Salem | Match Report | |
| Regular season | 24 | Mon | 2022-02-14 | 20:45 | Le Havre | 2.6 | 2–4 | 1.1 | Bastia | 4,464 | Stade Océane | Jérôme Miguelgorry | Match Report | |
| Regular season | 22 | Tue | 2022-02-15 | 19:00 | Grenoble | 0.6 | 1–0 | 1.3 | Niort | 3,025 | Stade Lesdiguières | Mikael Lesage | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 15:00 | Sochaux | 1.3 | 0–1 | 1.1 | Ajaccio | 12,067 | Stade Auguste-Bonal | Thomas Léonard | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Rodez Aveyron | 0.9 | 1–1 | 1.0 | Amiens | 1,068 | Stade Paul Lignon | Arnaud Baert | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Nîmes | 3.7 | 3–1 | 0.7 | Grenoble | 1,492 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Quevilly-Rouen | 0.4 | 1–1 | 1.3 | Valenciennes | 2,777 | Stade Robert Diochon | Guillaume Paradis | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Niort | 1.1 | 0–1 | 0.9 | Auxerre | 2,128 | Stade René Gaillard | Franck Schneider | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Nancy | 1.5 | 2–0 | 0.9 | Dunkerque | 3,412 | Stade Marcel Picot | Aurélien Petit | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Guingamp | 0.6 | 1–1 | 1.6 | Paris FC | 8,284 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Pau FC | 0.5 | 1–0 | 1.5 | Caen | 3,106 | Stade Nouste Camp | Nicolas Rainville | Match Report | |
| Regular season | 25 | Sat | 2022-02-19 | 19:00 | Bastia | 0.9 | 0–0 | 0.6 | Dijon | 8,500 | Stade Armand Césari | Remi Landry | Match Report | |
| Regular season | 25 | Mon | 2022-02-21 | 20:45 | Toulouse | 2.3 | 4–0 | 0.3 | Le Havre | 11,130 | Stadium Municipal | Mathieu Vernice | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 15:00 | Paris FC | 0.7 | 3–1 | 1.0 | Sochaux | 2,766 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Auxerre | 1.3 | 1–0 | 0.6 | Quevilly-Rouen | 5,214 | Stade de l'Abbé Deschamps | Remi Landry | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Valenciennes | 1.4 | 1–0 | 0.5 | Pau FC | 6,445 | Stade Nungesser | Benjamin Lepaysant | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Guingamp | 1.3 | 1–0 | 0.3 | Niort | 7,368 | Stade du Roudourou | Gaël Angoula | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Dunkerque | 0.8 | 2–1 | 1.5 | Dijon | 2,200 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Caen | 1.6 | 2–1 | 0.6 | Bastia | 8,980 | Stade Michel d'Ornano | Johan Hamel | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Le Havre | 1.6 | 1–0 | 0.4 | Nancy | 4,383 | Stade Municipal Jules Deschaseaux | Bartolomeu Varela | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Ajaccio | 1.0 | 2–1 | 0.9 | Rodez Aveyron | 2,500 | Stade François Coty | Mathieu Vernice | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 19:00 | Amiens | 1.3 | 3–0 | 1.0 | Nîmes | 7,354 | Stade Moulonguet | Marc Bollengier | Match Report | |
| Regular season | 26 | Mon | 2022-02-28 | 20:45 | Grenoble | 1.0 | 0–2 | 1.8 | Toulouse | 4,501 | Stade Lesdiguières | Olivier Thual | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 15:00 | Nîmes | 1.3 | 1–1 | 1.2 | Paris FC | 2,008 | Stade des Costières | Mathieu Vernice | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Dijon | 0.5 | 1–0 | 1.0 | Caen | 4,500 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Bastia | 0.7 | 1–1 | 0.9 | Valenciennes | 8,000 | Stade Armand Césari | Jérôme Brisard | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Sochaux | 2.1 | 1–0 | 1.4 | Guingamp | 7,099 | Stade Auguste-Bonal | Alexandre Perreau Niel | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Pau FC | 1.4 | 2–1 | 1.4 | Amiens | 2,356 | Stade Nouste Camp | Pierre Legat | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Rodez Aveyron | 0.6 | 1–3 | 1.2 | Auxerre | 1,393 | Stade Paul Lignon | Jérôme Miguelgorry | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Nancy | 2.0 | 0–1 | 0.3 | Grenoble | 7,000 | Stade Marcel Picot | Nicolas Rainville | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Quevilly-Rouen | 0.9 | 0–2 | 0.8 | Le Havre | 5,200 | Stade Robert Diochon | Marc Bollengier | Match Report | |
| Regular season | 27 | Sat | 2022-03-05 | 19:00 | Niort | 0.1 | 0–1 | 1.2 | Ajaccio | 1,973 | Stade René Gaillard | Aurélien Petit | Match Report | |
| Regular season | 27 | Mon | 2022-03-07 | 20:45 | Toulouse | 1.6 | 2–0 | 0.5 | Dunkerque | 8,955 | Stadium Municipal | Arnaud Baert | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 15:00 | Ajaccio | 0.6 | 0–1 | 0.2 | Bastia | 5,000 | Stade François Coty | Hakim Ben El Hadj Salem | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 15:00 | Auxerre | 1.9 | 3–2 | 1.9 | Sochaux | 10,091 | Stade de l'Abbé Deschamps | Benjamin Lepaysant | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Caen | 1.6 | 4–1 | 0.9 | Toulouse | 11,429 | Stade Michel d'Ornano | Guillaume Paradis | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Paris FC | 2.0 | 2–0 | 0.6 | Niort | 2,636 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Grenoble | 0.3 | 0–0 | 0.4 | Rodez Aveyron | 3,889 | Stade des Alpes | Franck Schneider | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Amiens | 1.6 | 1–0 | 0.9 | Nancy | 7,500 | Stade Crédit Agricole la Licorne | Gaël Angoula | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Valenciennes | 0.7 | 0–0 | 0.2 | Dijon | 5,119 | Stade du Hainaut | Mathieu Vernice | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Le Havre | 1.1 | 0–1 | 0.9 | Nîmes | 4,407 | Stade Océane | Pierre Legat | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Guingamp | 0.5 | 1–1 | 0.8 | Quevilly-Rouen | 7,794 | Stade du Roudourou | Abdelatif Kherradji | Match Report | |
| Regular season | 28 | Sat | 2022-03-12 | 19:00 | Dunkerque | 1.4 | 1–0 | 0.4 | Pau FC | 2,200 | Stade Marcel-Tribut | Bartolomeu Varela | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Niort | 1.4 | 1–1 | 1.0 | Sochaux | 1,802 | Stade René Gaillard | Nicolas Rainville | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Rodez Aveyron | 2.6 | 1–1 | 0.6 | Guingamp | 1,045 | Stade Paul Lignon | Arnaud Baert | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Quevilly-Rouen | 0.6 | 0–0 | 0.4 | Ajaccio | 2,689 | Stade Robert Diochon | Gaël Angoula | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Pau FC | 1.7 | 0–1 | 1.0 | Grenoble | 2,581 | Stade Nouste Camp | Mathieu Vernice | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Nîmes | 0.3 | 1–2 | 2.4 | Auxerre | 1,838 | Stade des Costières | Pierre Gaillouste | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Dijon | 1.0 | 2–0 | 0.5 | Le Havre | 4,500 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Toulouse | 4.7 | 6–0 | 0.7 | Amiens | 7,119 | Stadium Municipal | Remi Landry | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Valenciennes | 1.4 | 1–1 | 1.6 | Caen | 6,457 | Stade du Hainaut | Abdelatif Kherradji | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Nancy | 1.8 | 3–0 | 0.8 | Paris FC | 4,000 | Stade Marcel Picot | Jeremy Stinat | Match Report | |
| Regular season | 29 | Tue | 2022-03-15 | 19:00 | Bastia | 1.2 | 1–0 | 0.4 | Dunkerque | 5,000 | Stade Armand Césari | Alexandre Perreau Niel | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 15:00 | Le Havre | 1.6 | 2–4 | 3.5 | Caen | 18,693 | Stade Océane | Mathieu Vernice | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 15:00 | Auxerre | 0.4 | 1–2 | 2.6 | Toulouse | 14,360 | Stade de l'Abbé Deschamps | Stéphanie Frappart | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Niort | 1.2 | 2–0 | 0.7 | Quevilly-Rouen | 1,800 | Stade René Gaillard | Benjamin Lepaysant | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Ajaccio | 2.5 | 1–0 | 0.8 | Nîmes | 2,300 | Stade François Coty | Olivier Thual | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Dunkerque | 1.3 | 1–2 | 0.8 | Valenciennes | 4,000 | Stade Marcel-Tribut | Franck Schneider | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Sochaux | 2.4 | 2–0 | 0.3 | Rodez Aveyron | 6,497 | Stade Auguste-Bonal | Bartolomeu Varela | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Paris FC | 1.7 | 1–1 | 1.6 | Pau FC | 3,275 | Stade Sébastien Charléty | Remi Landry | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Amiens | 2.1 | 1–1 | 0.6 | Dijon | 6,032 | Stade Crédit Agricole la Licorne | Guillaume Paradis | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Guingamp | 2.2 | 3–1 | 2.1 | Nancy | 8,666 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| Regular season | 30 | Sat | 2022-03-19 | 19:00 | Grenoble | 0.9 | 1–1 | 1.4 | Bastia | 4,231 | Stade des Alpes | Pierre Legat | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 15:00 | Toulouse | 2.1 | 2–1 | 1.1 | Paris FC | 28,032 | Stadium Municipal | Aurélien Petit | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Dijon | 1.3 | 1–0 | 0.0 | Grenoble | 4,500 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Bastia | 0.5 | 1–1 | 1.0 | Auxerre | 3,000 | Stade Armand Césari | Franck Schneider | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Valenciennes | 1.4 | 0–2 | 0.8 | Amiens | 5,450 | Stade Nungesser | Arnaud Baert | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Quevilly-Rouen | 0.7 | 0–2 | 1.5 | Sochaux | 2,000 | Stade Robert Diochon | Pierre Legat | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Caen | 1.1 | 2–1 | 0.9 | Dunkerque | 10,720 | Stade Michel d'Ornano | Willy Delajod | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Rodez Aveyron | 0.5 | 1–1 | 0.5 | Niort | 1,004 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Nîmes | 0.7 | 0–2 | 1.9 | Guingamp | 1,345 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| Regular season | 31 | Sat | 2022-04-02 | 19:00 | Pau FC | 1.2 | 2–1 | 0.9 | Le Havre | 2,713 | Stade Nouste Camp | Gaël Angoula | Match Report | |
| Regular season | 31 | Mon | 2022-04-04 | 20:45 | Nancy | 1.0 | 0–2 | 2.3 | Ajaccio | 3,000 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 15:00 | Guingamp | 1.1 | 2–4 | 1.7 | Toulouse | 11,640 | Stade du Roudourou | Remi Landry | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Le Havre | 1.1 | 2–1 | 2.3 | Dunkerque | 4,332 | Stade Municipal Jules Deschaseaux | Bartolomeu Varela | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Ajaccio | 3.6 | 2–1 | 0.5 | Pau FC | 4,200 | Stade François Coty | Alexandre Perreau Niel | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Auxerre | 1.2 | 1–0 | 0.3 | Valenciennes | 11,447 | Stade de l'Abbé Deschamps | Gaël Angoula | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Sochaux | 1.3 | 1–0 | 0.9 | Nancy | 9,102 | Stade Auguste-Bonal | Guillaume Paradis | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Quevilly-Rouen | 1.1 | 2–0 | 1.8 | Rodez Aveyron | 4,568 | Stade Robert Diochon | Benoît Millot | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Niort | 1.4 | 0–0 | 0.4 | Nîmes | 2,000 | Stade René Gaillard | Marc Bollengier | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Amiens | 0.9 | 0–0 | 0.2 | Bastia | 2,697 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| Regular season | 32 | Sat | 2022-04-09 | 19:00 | Grenoble | 0.8 | 0–2 | 0.8 | Caen | 3,937 | Stade Lesdiguières | Jérôme Miguelgorry | Match Report | |
| Regular season | 32 | Mon | 2022-04-11 | 20:45 | Paris FC | 1.3 | 2–2 | 1.4 | Dijon | 3,034 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 15:00 | Pau FC | 0.6 | 1–4 | 3.0 | Auxerre | 3,406 | Stade Nouste Camp | Aurélien Petit | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 15:00 | Toulouse | 3.0 | 2–0 | 1.2 | Quevilly-Rouen | 12,348 | Stadium Municipal | Romain Lissorgue | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Valenciennes | 0.8 | 0–1 | 1.5 | Le Havre | 10,000 | Stade du Hainaut | Pierre Legat | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Nancy | 1.1 | 0–2 | 1.4 | Niort | 3,000 | Stade Marcel Picot | Arnaud Baert | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Dunkerque | 0.6 | 0–3 | 1.9 | Grenoble | 2,300 | Stade Marcel-Tribut | Mathieu Vernice | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Nîmes | 1.9 | 1–3 | 2.2 | Sochaux | 1,694 | Stade des Costières | Mikael Lesage | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Dijon | 0.6 | 0–3 | 1.2 | Ajaccio | 7,466 | Stade Gaston Gérard | Abdelatif Kherradji | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Bastia | 0.6 | 1–2 | 1.6 | Guingamp | 6,000 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Caen | 1.5 | 1–1 | 0.8 | Amiens | 11,263 | Stade Michel d'Ornano | Bartolomeu Varela | Match Report | |
| Regular season | 33 | Sat | 2022-04-16 | 19:00 | Rodez Aveyron | 0.8 | 0–1 | 0.4 | Paris FC | 1,442 | Stade Paul Lignon | Franck Schneider | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Auxerre | 1.7 | 2–1 | 0.6 | Dijon | 13,614 | Stade de l'Abbé Deschamps | Marc Bollengier | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Niort | 1.2 | 1–1 | 1.5 | Bastia | 2,045 | Stade René Gaillard | Thomas Léonard | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Rodez Aveyron | 1.7 | 1–1 | 1.7 | Nancy | 1,607 | Stade Paul Lignon | Gaël Angoula | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Quevilly-Rouen | 1.2 | 0–1 | 0.7 | Nîmes | 3,334 | Stade Robert Diochon | Aurélien Petit | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Paris FC | 0.6 | 1–0 | 0.9 | Caen | 3,423 | Stade Sébastien Charléty | Remi Landry | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Ajaccio | 1.4 | 2–1 | 1.3 | Dunkerque | 4,300 | Stade François Coty | Nicolas Rainville | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Guingamp | 1.9 | 3–0 | 1.3 | Pau FC | 8,291 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Grenoble | 1.9 | 3–0 | 0.4 | Valenciennes | 4,312 | Stade des Alpes | Olivier Thual | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Amiens | 1.0 | 0–2 | 1.8 | Le Havre | 6,574 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| Regular season | 34 | Tue | 2022-04-19 | 20:00 | Sochaux | 0.7 | 1–1 | 2.7 | Toulouse | 15,188 | Stade Auguste-Bonal | Benjamin Lepaysant | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Nîmes | 1.0 | 3–2 | 2.0 | Rodez Aveyron | 1,560 | Stade des Costières | Mathieu Vernice | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Le Havre | 0.8 | 0–1 | 0.7 | Grenoble | 4,830 | Stade Océane | Arnaud Baert | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Dunkerque | 0.7 | 0–0 | 1.5 | Amiens | 3,400 | Stade Marcel-Tribut | Olivier Thual | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Dijon | 2.4 | 3–3 | 4.3 | Guingamp | 5,000 | Stade Gaston Gérard | Eric Wattellier | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Bastia | 1.3 | 2–1 | 1.9 | Paris FC | 6,000 | Stade Armand Césari | Abdelatif Kherradji | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Nancy | 0–3 | Quevilly-Rouen | Stade Marcel Picot | Remi Landry | Match Report | Match awarded to Quevilly-Rouen | |||
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Valenciennes | 0.2 | 0–0 | 1.0 | Ajaccio | 15,451 | Stade du Hainaut | Franck Schneider | Match Report | |
| Regular season | 35 | Fri | 2022-04-22 | 21:00 | Pau FC | 1.5 | 0–1 | 0.8 | Sochaux | 3,363 | Stade Nouste Camp | Bartolomeu Varela | Match Report | |
| Regular season | 35 | Sat | 2022-04-23 | 15:00 | Caen | 1.1 | 1–1 | 1.0 | Auxerre | 14,935 | Stade Michel d'Ornano | Pierre Legat | Match Report | |
| Regular season | 35 | Mon | 2022-04-25 | 20:45 | Toulouse | 2.3 | 2–0 | 0.2 | Niort | 24,209 | Stadium Municipal | Alexandre Perreau Niel | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 15:00 | Auxerre | 1.5 | 1–0 | 0.9 | Dunkerque | 10,714 | Stade de l'Abbé Deschamps | Benjamin Lepaysant | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Grenoble | 1.7 | 1–1 | 1.1 | Amiens | 4,710 | Stade des Alpes | Gaël Angoula | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Guingamp | 2.6 | 2–1 | 1.0 | Caen | 10,950 | Stade du Roudourou | Arnaud Baert | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Ajaccio | 1.1 | 2–1 | 0.4 | Le Havre | 4,900 | Stade François Coty | Aurélien Petit | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Sochaux | 0.4 | 2–1 | 0.2 | Bastia | 14,005 | Stade Auguste-Bonal | Marc Bollengier | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Niort | 1.8 | 1–3 | 3.7 | Dijon | 2,000 | Stade René Gaillard | Pierre Legat | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Nancy | 2.9 | 1–3 | 1.5 | Nîmes | Stade Marcel Picot | Bartolomeu Varela | Match Report | ||
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Paris FC | 0.8 | 1–1 | 2.3 | Valenciennes | 4,017 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| Regular season | 36 | Sat | 2022-04-30 | 19:00 | Quevilly-Rouen | 0.7 | 1–2 | 1.2 | Pau FC | 3,708 | Stade Robert Diochon | Nicolas Rainville | Match Report | |
| Regular season | 36 | Mon | 2022-05-02 | 20:45 | Rodez Aveyron | 1.4 | 1–0 | 1.8 | Toulouse | 5,955 | Stade Paul Lignon | Florent Batta | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Valenciennes | 1.2 | 1–0 | 0.8 | Sochaux | 22,250 | Stade du Hainaut | Jeremy Stinat | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Pau FC | 2.3 | 2–2 | 1.4 | Niort | 3,518 | Stade Nouste Camp | Remi Landry | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Toulouse | 2.6 | 2–1 | 0.5 | Nîmes | 27,868 | Stadium Municipal | Jérôme Miguelgorry | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Le Havre | 1.9 | 1–2 | 2.3 | Auxerre | 8,058 | Stade Océane | Nicolas Rainville | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Caen | 0.9 | 2–0 | 1.2 | Quevilly-Rouen | 18,003 | Stade Michel d'Ornano | Franck Schneider | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Bastia | 0.7 | 0–1 | 1.4 | Rodez Aveyron | 8,000 | Stade Armand Césari | Pierre Legat | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Grenoble | 0.3 | 1–1 | 1.1 | Ajaccio | 5,673 | Stade des Alpes | Mathieu Vernice | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Amiens | 1.6 | 1–2 | 1.1 | Paris FC | 12,999 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Dunkerque | 2.6 | 1–3 | 1.1 | Guingamp | 3,500 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| Regular season | 37 | Sat | 2022-05-07 | 19:00 | Dijon | 1.4 | 2–3 | 1.1 | Nancy | 7,500 | Stade Gaston Gérard | Olivier Thual | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Auxerre | 1.7 | 2–1 | 0.6 | Amiens | 17,051 | Stade de l'Abbé Deschamps | Aurélien Petit | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Paris FC | 1.6 | 2–0 | 0.5 | Grenoble | 6,592 | Stade Sébastien Charléty | Marc Bollengier | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Quevilly-Rouen | 2.5 | 3–1 | 0.9 | Dunkerque | 4,078 | Stade Robert Diochon | Olivier Thual | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Rodez Aveyron | 1.1 | 2–0 | 1.1 | Caen | 1,667 | Stade Paul Lignon | Pierre Gaillouste | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Sochaux | 1.4 | 2–2 | 1.2 | Dijon | 19,019 | Stade Auguste-Bonal | Franck Schneider | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Nancy | 1.2 | 2–3 | 2.6 | Pau FC | 1,500 | Stade Marcel Picot | Arnaud Baert | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Nîmes | 0.4 | 0–2 | 1.2 | Bastia | 2,194 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Ajaccio | 2.1 | 1–0 | 0.6 | Toulouse | 8,516 | Stade François Coty | Bastien Dechepy | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Guingamp | 2.2 | 2–1 | 1.3 | Le Havre | 12,834 | Stade du Roudourou | Amaury Delerue | Match Report | |
| Regular season | 38 | Sat | 2022-05-14 | 19:00 | Niort | 1.3 | 1–2 | 2.0 | Valenciennes | 3,326 | Stade René Gaillard | Abdelatif Kherradji | Match Report | |
| French 2/3 Relegation/Promotion Playoff | Tue | 2022-05-24 | 20:30 | Villefranche | 1–3 | Quevilly-Rouen | 3,200 | Stade Armand Chouffet | Match Report | Leg 1 of 2 | ||||
| French 1/2 Relegation/Promotion Play-off | Thu | 2022-05-26 | 19:00 | Auxerre | 1–1 | Saint-Étienne | 17,479 | Stade de l'Abbé Deschamps | Match Report | Leg 1 of 2 | ||||
| French 2/3 Relegation/Promotion Playoff | Sun | 2022-05-29 | 16:00 | Quevilly-Rouen | 2–0 | Villefranche | 4,500 | Stade Robert Diochon | Match Report | Leg 2 of 2; Quevilly-Rouen won | ||||
| French 1/2 Relegation/Promotion Play-off | Sun | 2022-05-29 | 19:00 | Saint-Étienne | (4) 1–1 (5) | Auxerre | 24,489 | Stade Geoffroy-Guichard | Match Report | Leg 2 of 2; Auxerre won; Auxerre won on penalty kicks following extra time |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sat | 2021-07-24 | 15:00 | Bastia | 0.9 | 1–1 | 0.6 | Nîmes | 8,165 | Stade Armand Césari | Jérôme Miguelgorry | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Dunkerque | 0.8 | 1–1 | 1.1 | Quevilly-Rouen | 1,500 | Stade Marcel-Tribut | Olivier Thual | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Grenoble | 0.3 | 0–4 | 1.7 | Paris FC | 536 | Stade Jean Laville | Pierre Gaillouste | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Pau FC | 1.8 | 2–1 | 0.9 | Nancy | 1,803 | Stade Nouste Camp | Marc Bollengier | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Amiens | 1.2 | 1–2 | 1.4 | Auxerre | 5,562 | Stade Crédit Agricole la Licorne | Mathieu Vernice | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Valenciennes | 0.8 | 0–0 | 0.7 | Niort | 3,561 | Stade du Hainaut | Arnaud Baert | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Le Havre | 1.6 | 0–0 | 1.2 | Guingamp | 3,661 | Stade Océane | Remi Landry | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Toulouse | 1.1 | 2–2 | 0.4 | Ajaccio | 4,925 | Stadium Municipal | Franck Schneider | Match Report | |
| 1 | Sat | 2021-07-24 | 19:00 | Caen | 2.1 | 4–0 | 1.5 | Rodez Aveyron | 7,292 | Stade Michel d'Ornano | Guillaume Paradis | Match Report | |
| 1 | Mon | 2021-07-26 | 20:45 | Dijon | 0.7 | 1–3 | 2.2 | Sochaux | 7,641 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| 2 | Sat | 2021-07-31 | 15:00 | Nîmes | 2.6 | 2–1 | 0.8 | Dijon | 2,375 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Sochaux | 1.2 | 0–2 | 1.4 | Le Havre | 4,204 | Stade Gaston Gérard | Gaël Angoula | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Guingamp | 1.2 | 1–1 | 0.8 | Valenciennes | 6,291 | Stade du Roudourou | Mathieu Vernice | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Ajaccio | 0.9 | 3–1 | 1.5 | Amiens | 2,491 | Stade François Coty | Nicolas Rainville | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Rodez Aveyron | 0.4 | 1–0 | 0.3 | Pau FC | 1,346 | Stade Paul Lignon | Remi Landry | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Nancy | 0.7 | 0–4 | 2.3 | Toulouse | 5,678 | Stade Marcel Picot | Alexandre Perreau Niel | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Paris FC | 1.3 | 2–1 | 0.5 | Dunkerque | 2,148 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| 2 | Sat | 2021-07-31 | 19:00 | Niort | 0.3 | 0–1 | 0.6 | Caen | 1,523 | Stade René Gaillard | Abdelatif Kherradji | Match Report | |
| 2 | Mon | 2021-08-02 | 20:45 | Auxerre | 2.1 | 3–0 | 0.6 | Grenoble | 4,660 | Stade de l'Abbé Deschamps | Romain Lissorgue | Match Report | |
| 3 | Sat | 2021-08-07 | 15:00 | Caen | 0.7 | 1–2 | 1.7 | Sochaux | 9,177 | Stade Michel d'Ornano | Franck Schneider | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Auxerre | 0.8 | 0–0 | 0.5 | Ajaccio | 4,942 | Stade de l'Abbé Deschamps | Olivier Thual | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Grenoble | 0.6 | 0–0 | 0.8 | Guingamp | 309 | Stade Jean Laville | Jérôme Miguelgorry | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Pau FC | 0.9 | 0–1 | 0.4 | Toulouse | 3,342 | Stade Nouste Camp | Aurélien Petit | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Le Havre | 1.3 | 1–2 | 1.0 | Paris FC | 4,662 | Stade Océane | Arnaud Baert | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Dijon | 0.4 | 1–1 | 0.8 | Rodez Aveyron | 6,004 | Stade Gaston Gérard | Ruddy Buquet | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Amiens | 0.8 | 1–3 | 2.1 | Quevilly-Rouen | 5,584 | Stade Crédit Agricole la Licorne | Marc Bollengier | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Dunkerque | 0.6 | 1–2 | 0.6 | Niort | 1,584 | Stade Marcel-Tribut | Benjamin Lepaysant | Match Report | |
| 3 | Sat | 2021-08-07 | 19:00 | Valenciennes | 0.8 | 0–3 | 0.7 | Nîmes | 4,074 | Stade du Hainaut | Bartolomeu Varela | Match Report | |
| 3 | Wed | 2021-08-11 | 19:00 | Bastia | 0.7 | 1–1 | 1.4 | Nancy | 10,025 | Stade Armand Césari | Pierre Gaillouste | Match Report | |
| 4 | Sat | 2021-08-14 | 15:00 | Toulouse | 1.5 | 1–0 | 0.3 | Bastia | 6,249 | Stadium Municipal | Antony Gautier | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Quevilly-Rouen | 2.6 | 2–1 | 1.1 | Dijon | 816 | Stade Michel d'Ornano | Gaël Angoula | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Guingamp | 0.9 | 0–2 | 1.2 | Amiens | 6,518 | Stade du Roudourou | Alexandre Perreau Niel | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Niort | 0.6 | 1–0 | 2.2 | Grenoble | 1,329 | Stade René Gaillard | Guillaume Paradis | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Nîmes | 1.5 | 0–0 | 1.3 | Pau FC | 1,849 | Stade des Costières | Mathieu Vernice | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Sochaux | 1.9 | 1–0 | 1.3 | Dunkerque | 6,388 | Stade Auguste-Bonal | Bartolomeu Varela | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Rodez Aveyron | 0.8 | 0–0 | 1.0 | Le Havre | 1,496 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| 4 | Sat | 2021-08-14 | 19:00 | Nancy | 0.6 | 0–1 | 2.3 | Valenciennes | 5,725 | Stade Marcel Picot | Pierre Legat | Match Report | |
| 4 | Mon | 2021-08-16 | 20:45 | Paris FC | 1.2 | 1–1 | 1.5 | Auxerre | 3,253 | Stade Sébastien Charléty | Nicolas Rainville | Match Report | |
| 2 | Wed | 2021-08-18 | 19:00 | Quevilly-Rouen | 1.4 | 1–2 | 1.3 | Bastia | 895 | Stade Michel d'Ornano | Pierre Legat | Match Report | |
| 5 | Sat | 2021-08-21 | 15:00 | Dijon | 1.6 | 2–4 | 2.3 | Toulouse | 6,756 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Amiens | 0.3 | 0–0 | 1.5 | Sochaux | 5,982 | Stade Moulonguet | Jérôme Miguelgorry | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Le Havre | 1.6 | 2–1 | 1.3 | Niort | 4,394 | Stade Municipal Jules Deschaseaux | Marc Bollengier | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Pau FC | 1.5 | 2–0 | 1.3 | Bastia | 2,600 | Stade Nouste Camp | Arnaud Baert | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Valenciennes | 1.3 | 1–4 | 0.8 | Rodez Aveyron | 4,366 | Stade Nungesser | Benjamin Lepaysant | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Dunkerque | 0.6 | 0–2 | 1.0 | Nîmes | 1,498 | Stade Marcel-Tribut | Alexandre Perreau Niel | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Caen | 1.2 | 1–0 | 0.7 | Nancy | 8,855 | Stade Michel d'Ornano | Olivier Thual | Match Report | |
| 5 | Sat | 2021-08-21 | 19:00 | Grenoble | 2.3 | 2–0 | 0.5 | Quevilly-Rouen | 3,630 | Stade Lesdiguières | Franck Schneider | Match Report | |
| 5 | Mon | 2021-08-23 | 20:45 | Auxerre | 1.2 | 1–2 | 1.5 | Guingamp | 6,516 | Stade de l'Abbé Deschamps | Aurélien Petit | Match Report | |
| 4 | Wed | 2021-08-25 | 19:00 | Ajaccio | 2.2 | 2–0 | 0.5 | Caen | 2,830 | Stade François Coty | Remi Landry | Match Report | |
| 6 | Sat | 2021-08-28 | 15:00 | Nîmes | 0.7 | 0–0 | 0.8 | Caen | 3,296 | Stade des Costières | Florent Batta | Match Report | |
| 6 | Sat | 2021-08-28 | 15:00 | Toulouse | 1.1 | 1–0 | 0.6 | Valenciennes | 7,614 | Stadium Municipal | Mathieu Vernice | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Sochaux | 0.8 | 1–0 | 0.3 | Grenoble | 7,367 | Stade Auguste-Bonal | Olivier Thual | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Rodez Aveyron | 1.1 | 2–2 | 0.8 | Dunkerque | 1,393 | Stade Paul Lignon | Pierre Legat | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Niort | 1.6 | 0–0 | 0.3 | Amiens | 1,598 | Stade René Gaillard | Bartolomeu Varela | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Quevilly-Rouen | 0.4 | 0–1 | 2.5 | Paris FC | 2,789 | Stade Robert Diochon | Remi Landry | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Nancy | 2.5 | 1–4 | 2.7 | Auxerre | 5,977 | Stade Marcel Picot | Gaël Angoula | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Bastia | 1.6 | 0–0 | 0.3 | Le Havre | 8,742 | Stade Armand Césari | Aurélien Petit | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Guingamp | 0.6 | 1–1 | 1.4 | Ajaccio | 6,200 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| 6 | Sat | 2021-08-28 | 19:00 | Pau FC | 1.6 | 2–0 | 0.8 | Dijon | 2,263 | Stade Nouste Camp | Abdelatif Kherradji | Match Report | |
| 7 | Sat | 2021-09-11 | 15:00 | Paris FC | 1.8 | 0–1 | 1.0 | Guingamp | 3,298 | Stade Sébastien Charléty | Marc Bollengier | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Dunkerque | 1.1 | 0–0 | 1.1 | Nancy | 1,950 | Stade Marcel-Tribut | Benjamin Lepaysant | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Valenciennes | 0.8 | 1–2 | 1.6 | Quevilly-Rouen | 5,666 | Stade du Hainaut | Arnaud Baert | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Caen | 1.7 | 1–2 | 1.2 | Pau FC | 8,867 | Stade Michel d'Ornano | Alexandre Perreau Niel | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Auxerre | 1.7 | 4–0 | 0.8 | Niort | 7,802 | Stade de l'Abbé Deschamps | Abdelatif Kherradji | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Grenoble | 1.5 | 2–1 | 0.8 | Nîmes | 5,274 | Stade des Alpes | Bastien Dechepy | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Ajaccio | 0.7 | 1–0 | 0.7 | Sochaux | 2,474 | Stade François Coty | Franck Schneider | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Dijon | 0.6 | 2–1 | 2.1 | Bastia | 7,249 | Stade Gaston Gérard | Bartolomeu Varela | Match Report | |
| 7 | Sat | 2021-09-11 | 19:00 | Amiens | 1.0 | 0–1 | 1.1 | Rodez Aveyron | 5,853 | Stade Crédit Agricole la Licorne | Nicolas Rainville | Match Report | |
| 7 | Mon | 2021-09-13 | 20:45 | Le Havre | 0.9 | 1–1 | 1.0 | Toulouse | 5,998 | Stade Océane | Gaël Angoula | Match Report | |
| 5 | Tue | 2021-09-14 | 19:00 | Ajaccio | 0.9 | 1–0 | 1.3 | Paris FC | 2,573 | Stade François Coty | Jeremy Stinat | Match Report | |
| 8 | Sat | 2021-09-18 | 15:00 | Sochaux | 1.2 | 2–0 | 0.6 | Paris FC | 7,948 | Stade Auguste-Bonal | Jérémie Pignard | Match Report | |
| 8 | Sat | 2021-09-18 | 15:00 | Toulouse | 3.3 | 4–1 | 0.3 | Grenoble | 8,969 | Stadium Municipal | Alexandre Perreau Niel | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Quevilly-Rouen | 0.8 | 0–0 | 1.0 | Auxerre | 3,549 | Stade Robert Diochon | Olivier Thual | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Nancy | 1.9 | 1–1 | 0.5 | Le Havre | 6,649 | Stade Marcel Picot | Franck Schneider | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Pau FC | 1.5 | 1–1 | 1.6 | Valenciennes | 2,735 | Stade Nouste Camp | Pierre Legat | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Nîmes | 1.4 | 3–3 | 2.8 | Amiens | 2,497 | Stade des Costières | Remi Landry | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Dijon | 1.8 | 2–0 | 0.7 | Dunkerque | 7,000 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Rodez Aveyron | 0.6 | 0–2 | 0.8 | Ajaccio | 1,576 | Stade Paul Lignon | Gaël Angoula | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Bastia | 1.1 | 1–1 | 1.2 | Caen | 7,682 | Stade Armand Césari | Guillaume Paradis | Match Report | |
| 8 | Sat | 2021-09-18 | 19:00 | Niort | 1.0 | 2–0 | 0.7 | Guingamp | 1,846 | Stade René Gaillard | Mathieu Vernice | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Valenciennes | 1.7 | 2–1 | 1.0 | Bastia | 4,638 | Stade du Hainaut | Alexandre Perreau Niel | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Le Havre | 1.9 | 1–0 | 0.6 | Quevilly-Rouen | 7,650 | Stade Océane | Mathieu Vernice | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Guingamp | 1.4 | 1–2 | 1.1 | Sochaux | 7,088 | Stade du Roudourou | Nicolas Rainville | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Ajaccio | 1.1 | 0–0 | 0.6 | Niort | 2,622 | Stade François Coty | Benjamin Lepaysant | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Auxerre | 1.0 | 1–0 | 0.5 | Rodez Aveyron | 7,445 | Stade de l'Abbé Deschamps | Bartolomeu Varela | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Amiens | 0.5 | 2–2 | 2.5 | Pau FC | 5,715 | Stade Crédit Agricole la Licorne | Marc Bollengier | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Grenoble | 2.2 | 4–1 | 1.5 | Nancy | 3,845 | Stade des Alpes | Pierre Legat | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Caen | 1.6 | 0–1 | 0.6 | Dijon | 8,391 | Stade Michel d'Ornano | Gaël Angoula | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Paris FC | 1.9 | 2–0 | 0.8 | Nîmes | 2,726 | Stade Sébastien Charléty | Pierre Gaillouste | Match Report | |
| 9 | Tue | 2021-09-21 | 20:00 | Dunkerque | 0.6 | 0–2 | 1.8 | Toulouse | 1,752 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Quevilly-Rouen | 1.4 | 2–2 | 1.2 | Guingamp | 3,513 | Stade Robert Diochon | Guillaume Paradis | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Rodez Aveyron | 1.3 | 1–1 | 0.8 | Grenoble | 1,285 | Stade Paul Lignon | Jérôme Miguelgorry | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Sochaux | 0.8 | 0–0 | 0.3 | Auxerre | 9,185 | Stade Auguste-Bonal | Remi Landry | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Pau FC | 3.0 | 1–2 | 0.6 | Dunkerque | 2,092 | Stade Nouste Camp | Mathieu Vernice | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Dijon | 2.3 | 0–1 | 0.3 | Valenciennes | 7,118 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Nîmes | 0.6 | 0–1 | 0.8 | Le Havre | 2,540 | Stade des Costières | Aurélien Petit | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Niort | 0.7 | 4–1 | 3.0 | Paris FC | 1,802 | Stade René Gaillard | Nicolas Rainville | Match Report | |
| 10 | Fri | 2021-09-24 | 21:00 | Nancy | 1.1 | 1–1 | 0.4 | Amiens | 6,010 | Stade Marcel Picot | Olivier Thual | Match Report | |
| 10 | Sat | 2021-09-25 | 15:00 | Bastia | 1.1 | 2–0 | 0.4 | Ajaccio | 11,686 | Stade Armand Césari | Florent Batta | Match Report | |
| 10 | Mon | 2021-09-27 | 20:45 | Toulouse | 2.1 | 2–3 | 1.6 | Caen | 9,856 | Stadium Municipal | Bartolomeu Varela | Match Report | |
| 11 | Sat | 2021-10-02 | 15:00 | Auxerre | 0.9 | 2–2 | 1.6 | Nîmes | 9,479 | Stade de l'Abbé Deschamps | Romain Lissorgue | Match Report | |
| 11 | Sat | 2021-10-02 | 15:00 | Amiens | 0.4 | 0–0 | 1.1 | Toulouse | 11,733 | Stade Crédit Agricole la Licorne | Mathieu Vernice | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Caen | 1.5 | 1–2 | 2.2 | Valenciennes | 8,490 | Stade Michel d'Ornano | Abdelatif Kherradji | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Dunkerque | 0.8 | 2–0 | 0.9 | Bastia | 2,150 | Stade Marcel-Tribut | Remi Landry | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Guingamp | 1.1 | 2–1 | 1.1 | Rodez Aveyron | 6,756 | Stade du Roudourou | Pierre Legat | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Sochaux | 1.4 | 1–0 | 0.4 | Niort | 10,678 | Stade Auguste-Bonal | Aurélien Petit | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Le Havre | 1.5 | 2–0 | 1.5 | Dijon | 5,096 | Stade Océane | Marc Bollengier | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Ajaccio | 0.7 | 0–1 | 0.4 | Quevilly-Rouen | 2,497 | Stade François Coty | Alexandre Perreau Niel | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Paris FC | 1.1 | 1–1 | 1.3 | Nancy | 2,710 | Stade Sébastien Charléty | Gaël Angoula | Match Report | |
| 11 | Sat | 2021-10-02 | 19:00 | Grenoble | 1.2 | 2–0 | 0.7 | Pau FC | 4,427 | Stade des Alpes | Benjamin Lepaysant | Match Report | |
| 12 | Sat | 2021-10-16 | 15:00 | Toulouse | 1.9 | 6–0 | 0.3 | Auxerre | 10,302 | Stadium Municipal | Franck Schneider | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Pau FC | 1.6 | 1–0 | 0.8 | Paris FC | 2,854 | Stade Nouste Camp | Arnaud Baert | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Rodez Aveyron | 0.5 | 0–1 | 0.4 | Sochaux | 1,541 | Stade Paul Lignon | Olivier Thual | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Valenciennes | 2.5 | 1–3 | 1.7 | Dunkerque | 10,429 | Stade du Hainaut | Benjamin Lepaysant | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Caen | 1.1 | 2–2 | 1.0 | Le Havre | 16,729 | Stade Michel d'Ornano | Hakim Ben El Hadj Salem | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Bastia | 1.1 | 0–0 | 0.8 | Grenoble | 8,303 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Nancy | 1.6 | 2–1 | 1.0 | Guingamp | 5,000 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Quevilly-Rouen | 0.2 | 0–3 | 1.8 | Niort | 3,300 | Stade Robert Diochon | Bartolomeu Varela | Match Report | |
| 12 | Sat | 2021-10-16 | 19:00 | Dijon | 0.5 | 1–0 | 1.1 | Amiens | 7,445 | Stade Gaston Gérard | Jérôme Miguelgorry | Match Report | |
| 12 | Mon | 2021-10-18 | 20:45 | Nîmes | 0.7 | 0–2 | 1.9 | Ajaccio | 2,329 | Stade des Costières | Guillaume Paradis | Match Report | |
| 13 | Sat | 2021-10-23 | 15:00 | Paris FC | 1.1 | 2–2 | 2.0 | Toulouse | 4,068 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Guingamp | 2.0 | 3–1 | 1.3 | Nîmes | 9,983 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Le Havre | 0.9 | 1–0 | 0.7 | Pau FC | 5,439 | Stade Municipal Jules Deschaseaux | Abdelatif Kherradji | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Amiens | 1.0 | 3–0 | 1.6 | Valenciennes | 8,781 | Stade Moulonguet | Bartolomeu Varela | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Grenoble | 0.2 | 1–2 | 2.3 | Dijon | 5,714 | Stade Lesdiguières | Gaël Angoula | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Sochaux | 1.5 | 1–1 | 0.6 | Quevilly-Rouen | 9,081 | Stade Auguste-Bonal | Jeremy Stinat | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Niort | 0.9 | 0–2 | 1.0 | Rodez Aveyron | 2,439 | Stade René Gaillard | Alexandre Perreau Niel | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Ajaccio | 1.9 | 2–0 | 0.5 | Nancy | 2,713 | Stade François Coty | Mathieu Vernice | Match Report | |
| 13 | Sat | 2021-10-23 | 19:00 | Dunkerque | 1.2 | 1–1 | 1.1 | Caen | 2,500 | Stade Marcel-Tribut | Aurélien Petit | Match Report | |
| 13 | Mon | 2021-10-25 | 20:45 | Auxerre | 0.3 | 1–0 | 0.7 | Bastia | 8,559 | Stade de l'Abbé Deschamps | Pierre Legat | Match Report | |
| 14 | Sat | 2021-10-30 | 15:00 | Toulouse | 1.1 | 2–2 | 1.5 | Guingamp | 10,491 | Stadium Municipal | Nicolas Rainville | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Caen | 0.6 | 0–1 | 1.9 | Grenoble | 8,651 | Stade Michel d'Ornano | Arnaud Baert | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Pau FC | 0.7 | 1–0 | 0.6 | Ajaccio | 2,691 | Stade Nouste Camp | Marc Bollengier | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Bastia | 1.2 | 0–0 | 1.1 | Amiens | 8,018 | Stade Armand Césari | Thomas Léonard | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Nîmes | 0.8 | 1–2 | 1.8 | Niort | 1,174 | Stade des Costières | Olivier Thual | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Rodez Aveyron | 1.1 | 3–0 | 0.8 | Quevilly-Rouen | 1,521 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Dunkerque | 1.2 | 1–0 | 0.6 | Le Havre | 2,200 | Stade Marcel-Tribut | Pierre Legat | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Nancy | 1.1 | 0–0 | 0.8 | Sochaux | 8,114 | Stade Marcel Picot | Benjamin Lepaysant | Match Report | |
| 14 | Sat | 2021-10-30 | 19:00 | Dijon | 2.4 | 0–1 | 0.8 | Paris FC | 7,660 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| 14 | Mon | 2021-11-01 | 20:45 | Valenciennes | 0.7 | 1–2 | 1.7 | Auxerre | 6,574 | Stade Nungesser | Aurélien Petit | Match Report | |
| 15 | Sat | 2021-11-06 | 15:00 | Sochaux | 1.6 | 0–1 | 1.3 | Nîmes | 9,780 | Stade Auguste-Bonal | Bastien Dechepy | Match Report | |
| 15 | Sat | 2021-11-06 | 15:00 | Auxerre | 2.0 | 4–1 | 1.0 | Pau FC | 10,308 | Stade de l'Abbé Deschamps | Guillaume Paradis | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Niort | 1.9 | 1–3 | 2.0 | Nancy | 2,050 | Stade René Gaillard | Jérôme Miguelgorry | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Ajaccio | 2.0 | 1–0 | 0.2 | Dijon | 2,532 | Stade François Coty | Bartolomeu Varela | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Paris FC | 1.2 | 1–0 | 0.6 | Rodez Aveyron | 2,477 | Stade Sébastien Charléty | Mathieu Vernice | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Le Havre | 0.7 | 0–0 | 0.2 | Valenciennes | 5,504 | Stade Océane | Arnaud Baert | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Grenoble | 1.5 | 1–0 | 0.1 | Dunkerque | 4,171 | Stade des Alpes | Franck Schneider | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Amiens | 0.3 | 0–0 | 0.5 | Caen | 8,790 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Quevilly-Rouen | 0.4 | 0–0 | 1.7 | Toulouse | 4,079 | Stade Robert Diochon | Gaël Angoula | Match Report | |
| 15 | Sat | 2021-11-06 | 19:00 | Guingamp | 1.1 | 2–3 | 1.2 | Bastia | 8,769 | Stade du Roudourou | Benjamin Lepaysant | Match Report | |
| 16 | Sat | 2021-11-20 | 15:00 | Toulouse | 1.5 | 4–1 | 1.1 | Sochaux | 15,069 | Stadium Municipal | Olivier Thual | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Caen | 1.1 | 0–1 | 1.4 | Paris FC | 11,635 | Stade Michel d'Ornano | Marc Bollengier | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Valenciennes | 1.8 | 1–0 | 0.3 | Grenoble | 4,927 | Stade Nungesser | Gaël Angoula | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Nîmes | 1.3 | 2–1 | 1.8 | Quevilly-Rouen | 1,203 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Dunkerque | 0.8 | 0–1 | 0.7 | Ajaccio | 2,084 | Stade Marcel-Tribut | Arnaud Baert | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Nancy | 1.3 | 0–2 | 1.8 | Rodez Aveyron | 8,680 | Stade Marcel Picot | Pierre Legat | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Bastia | 1.6 | 2–0 | 1.4 | Niort | 7,728 | Stade Armand Césari | Johan Hamel | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Pau FC | 2.2 | 2–0 | 1.8 | Guingamp | 2,443 | Stade Nouste Camp | Franck Schneider | Match Report | |
| 16 | Sat | 2021-11-20 | 19:00 | Le Havre | 1.1 | 1–1 | 2.2 | Amiens | 5,120 | Stade Municipal Jules Deschaseaux | Jérôme Miguelgorry | Match Report | |
| 16 | Mon | 2021-11-22 | 20:45 | Dijon | 2.5 | 3–1 | 1.2 | Auxerre | 11,301 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Paris FC | 2.0 | 1–0 | 0.4 | Bastia | 2,764 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Ajaccio | 1.4 | 0–0 | 0.1 | Valenciennes | 3,197 | Stade François Coty | Pierre Legat | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Grenoble | 0.8 | 1–2 | 1.5 | Le Havre | 4,085 | Stade Lesdiguières | Marc Bollengier | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Quevilly-Rouen | 1.0 | 2–1 | 1.3 | Nancy | 2,912 | Stade Robert Diochon | Bartolomeu Varela | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Rodez Aveyron | 1.5 | 1–0 | 0.7 | Nîmes | 1,567 | Stade Paul Lignon | Guillaume Paradis | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Amiens | 3.5 | 3–0 | 0.4 | Dunkerque | 7,626 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Sochaux | 1.4 | 2–1 | 0.4 | Pau FC | 7,049 | Stade Auguste-Bonal | Nicolas Rainville | Match Report | |
| 17 | Fri | 2021-12-03 | 21:00 | Guingamp | 1.3 | 3–2 | 1.0 | Dijon | 7,388 | Stade du Roudourou | Aurélien Petit | Match Report | |
| 17 | Sat | 2021-12-04 | 15:00 | Auxerre | 1.2 | 2–2 | 1.2 | Caen | 6,366 | Stade de l'Abbé Deschamps | Jérôme Miguelgorry | Match Report | |
| 17 | Mon | 2021-12-06 | 20:45 | Niort | 1.2 | 2–1 | 2.3 | Toulouse | 2,370 | Stade René Gaillard | Eric Wattellier | Match Report | |
| 18 | Sat | 2021-12-11 | 15:00 | Le Havre | 1.2 | 0–1 | 0.6 | Ajaccio | 7,400 | Stade Municipal Jules Deschaseaux | Jérôme Brisard | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Nîmes | 2.2 | 2–1 | 1.7 | Nancy | 1,210 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Amiens | 2.0 | 4–1 | 0.6 | Grenoble | 7,853 | Stade Moulonguet | Franck Schneider | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Dijon | 0.9 | 2–2 | 1.2 | Niort | 6,820 | Stade Gaston Gérard | Abdelatif Kherradji | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Valenciennes | 1.1 | 1–4 | 3.1 | Paris FC | 7,572 | Stade Nungesser | Arnaud Baert | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Pau FC | 1.5 | 1–2 | 1.0 | Quevilly-Rouen | 2,171 | Stade Nouste Camp | Gaël Angoula | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Bastia | 1.5 | 2–2 | 1.9 | Sochaux | 7,611 | Stade Armand Césari | Aurélien Petit | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Dunkerque | 0.1 | 0–2 | 1.9 | Auxerre | 1,925 | Stade Marcel-Tribut | Guillaume Paradis | Match Report | |
| 18 | Sat | 2021-12-11 | 19:00 | Caen | 2.4 | 2–0 | 0.8 | Guingamp | 9,834 | Stade Michel d'Ornano | Mathieu Vernice | Match Report | |
| 18 | Mon | 2021-12-13 | 20:45 | Toulouse | 1.2 | 1–1 | 0.3 | Rodez Aveyron | 11,577 | Stadium Municipal | Nicolas Rainville | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Quevilly-Rouen | 1.5 | 2–2 | 1.0 | Caen | 5,058 | Stade Michel d'Ornano | Alexandre Perreau Niel | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Niort | 1.6 | 3–0 | 0.4 | Pau FC | 2,173 | Stade René Gaillard | Aurélien Petit | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Nancy | 1.0 | 0–3 | 1.6 | Dijon | 138 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Nîmes | 1.2 | 1–2 | 1.3 | Toulouse | 2,064 | Stade des Costières | Willy Delajod | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Guingamp | 1.9 | 2–1 | 0.5 | Dunkerque | 7,277 | Stade du Roudourou | Olivier Thual | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Ajaccio | 0.8 | 1–0 | 0.3 | Grenoble | 3,472 | Stade François Coty | Arnaud Baert | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Sochaux | 1.1 | 1–1 | 1.0 | Valenciennes | 7,221 | Stade Auguste-Bonal | Abdelatif Kherradji | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Auxerre | 1.7 | 2–3 | 1.2 | Le Havre | 6,985 | Stade de l'Abbé Deschamps | Pierre Legat | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Paris FC | 0.3 | 1–0 | 1.0 | Amiens | 2,596 | Stade Sébastien Charléty | Gaël Angoula | Match Report | |
| 19 | Tue | 2021-12-21 | 20:45 | Rodez Aveyron | 0.5 | 0–0 | 0.5 | Bastia | 1,567 | Stade Paul Lignon | Franck Schneider | Match Report | |
| 20 | Sat | 2022-01-08 | 15:00 | Le Havre | 0.7 | 0–1 | 0.8 | Sochaux | 4,998 | Stade Océane | Marc Bollengier | Match Report | |
| 20 | Sat | 2022-01-08 | 19:00 | Pau FC | 2.4 | 4–0 | 0.7 | Rodez Aveyron | 2,162 | Stade Nouste Camp | Bartolomeu Varela | Match Report | |
| 20 | Sat | 2022-01-08 | 19:00 | Grenoble | 0.6 | 0–1 | 0.9 | Auxerre | 3,881 | Stade Lesdiguières | Benjamin Lepaysant | Match Report | |
| 20 | Sat | 2022-01-08 | 19:00 | Dijon | 1.6 | 1–2 | 1.4 | Nîmes | 5,400 | Stade Gaston Gérard | Mathieu Vernice | Match Report | |
| 20 | Sat | 2022-01-08 | 19:00 | Bastia | 2.1 | 3–0 | 0.4 | Quevilly-Rouen | 5,000 | Stade Armand Césari | Ruddy Buquet | Match Report | |
| 20 | Sat | 2022-01-08 | 19:00 | Valenciennes | 0.5 | 1–1 | 1.6 | Guingamp | 4,146 | Stade Nungesser | Gaël Angoula | Match Report | |
| 21 | Sat | 2022-01-15 | 19:00 | Rodez Aveyron | 1.5 | 0–2 | 1.5 | Dijon | 1,165 | Stade Paul Lignon | Nicolas Rainville | Match Report | |
| 21 | Sat | 2022-01-15 | 19:00 | Nancy | 1.3 | 2–1 | 1.1 | Bastia | 4,983 | Stade Marcel Picot | Jérôme Miguelgorry | Match Report | |
| 21 | Sat | 2022-01-15 | 19:00 | Toulouse | 2.1 | 1–1 | 0.5 | Pau FC | 5,281 | Stadium Municipal | Franck Schneider | Match Report | |
| 21 | Sat | 2022-01-15 | 19:00 | Guingamp | 1.0 | 0–0 | 0.5 | Grenoble | 2,699 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| 21 | Sat | 2022-01-15 | 20:00 | Sochaux | 2.3 | 3–2 | 1.2 | Caen | 5,000 | Stade Auguste-Bonal | Aurélien Petit | Match Report | |
| 21 | Mon | 2022-01-17 | 20:45 | Paris FC | 1.3 | 2–2 | 1.3 | Le Havre | 910 | Stade Sébastien Charléty | Bartolomeu Varela | Match Report | |
| 20 | Wed | 2022-01-19 | 19:00 | Amiens | 1.3 | 0–1 | 0.7 | Ajaccio | 2,500 | Stade Moulonguet | Guillaume Paradis | Match Report | |
| 20 | Wed | 2022-01-19 | 19:00 | Toulouse | 1.9 | 4–0 | 0.4 | Nancy | 5,482 | Stadium Municipal | Olivier Thual | Match Report | |
| 22 | Sat | 2022-01-22 | 19:00 | Amiens | 1.0 | 3–0 | 2.1 | Guingamp | 4,000 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| 22 | Sat | 2022-01-22 | 19:00 | Le Havre | 0.9 | 0–0 | 0.2 | Rodez Aveyron | 4,045 | Stade Océane | Abdelatif Kherradji | Match Report | |
| 22 | Sat | 2022-01-22 | 19:00 | Bastia | 0.3 | 0–0 | 1.0 | Toulouse | 5,000 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| 22 | Sat | 2022-01-22 | 19:00 | Dunkerque | 0.2 | 0–0 | 1.4 | Sochaux | 2,300 | Stade Marcel-Tribut | Arnaud Baert | Match Report | |
| 22 | Sat | 2022-01-22 | 19:00 | Dijon | 2.1 | 1–0 | 0.5 | Quevilly-Rouen | 3,093 | Stade Gaston Gérard | Bartolomeu Varela | Match Report | |
| 22 | Mon | 2022-01-24 | 20:45 | Caen | 1.3 | 2–0 | 0.3 | Ajaccio | 5,000 | Stade Michel d'Ornano | Jeremy Stinat | Match Report | |
| 21 | Wed | 2022-01-26 | 19:00 | Quevilly-Rouen | 0.8 | 1–1 | 1.0 | Amiens | 2,200 | Stade Robert Diochon | Abdelatif Kherradji | Match Report | |
| 20 | Fri | 2022-01-28 | 19:00 | Caen | 1.5 | 0–2 | 0.9 | Niort | 3,000 | Stade Michel d'Ornano | Arnaud Baert | Match Report | |
| 20 | Fri | 2022-01-28 | 19:00 | Dunkerque | 1.2 | 1–1 | 1.9 | Paris FC | 2,300 | Stade Marcel-Tribut | Nicolas Rainville | Match Report | |
| 21 | Fri | 2022-01-28 | 19:00 | Ajaccio | 1.7 | 0–0 | 0.5 | Auxerre | 3,300 | Stade François Coty | Mathieu Vernice | Match Report | |
| 21 | Fri | 2022-01-28 | 19:00 | Nîmes | 2.5 | 2–1 | 1.6 | Valenciennes | 1,378 | Stade des Costières | Romain Lissorgue | Match Report | |
| 21 | Tue | 2022-02-01 | 19:00 | Niort | 1.1 | 2–0 | 0.6 | Dunkerque | 1,614 | Stade René Gaillard | Jérôme Miguelgorry | Match Report | |
| 22 | Tue | 2022-02-01 | 19:00 | Auxerre | 2.7 | 1–2 | 2.2 | Paris FC | 4,331 | Stade de l'Abbé Deschamps | Gaël Angoula | Match Report | |
| 22 | Tue | 2022-02-01 | 19:00 | Valenciennes | 3.9 | 6–1 | 1.1 | Nancy | 3,830 | Stade Nungesser | Mathieu Vernice | Match Report | |
| 22 | Tue | 2022-02-01 | 19:00 | Pau FC | 1.3 | 0–3 | 2.4 | Nîmes | 2,224 | Stade Nouste Camp | Remi Landry | Match Report | |
| 23 | Sat | 2022-02-05 | 15:00 | Toulouse | 2.5 | 4–1 | 1.1 | Dijon | 11,000 | Stadium Municipal | Marc Bollengier | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Nîmes | 0.5 | 0–1 | 1.1 | Dunkerque | 1,500 | Stade des Costières | Pierre Legat | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Niort | 0.4 | 0–0 | 0.7 | Le Havre | 2,021 | Stade René Gaillard | Aurélien Petit | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Nancy | 1.7 | 1–1 | 1.3 | Caen | 4,000 | Stade Marcel Picot | Remi Landry | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Sochaux | 1.6 | 1–1 | 0.5 | Amiens | 6,623 | Stade Auguste-Bonal | Franck Schneider | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Guingamp | 1.1 | 1–1 | 1.0 | Auxerre | 7,422 | Stade du Roudourou | Abdelatif Kherradji | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Rodez Aveyron | 0.8 | 0–0 | 0.6 | Valenciennes | 1,198 | Stade Paul Lignon | Olivier Thual | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Quevilly-Rouen | 0.7 | 1–0 | 0.5 | Grenoble | 2,400 | Stade Robert Diochon | Arnaud Baert | Match Report | |
| 23 | Sat | 2022-02-05 | 19:00 | Bastia | 1.8 | 1–1 | 0.7 | Pau FC | 7,500 | Stade Armand Césari | Guillaume Paradis | Match Report | |
| 23 | Mon | 2022-02-07 | 20:45 | Paris FC | 1.5 | 2–0 | 0.8 | Ajaccio | 900 | Stade Sébastien Charléty | Hakim Ben El Hadj Salem | Match Report | |
| 24 | Sat | 2022-02-12 | 15:00 | Valenciennes | 0.3 | 1–3 | 2.6 | Toulouse | 5,303 | Stade du Hainaut | Bartolomeu Varela | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Paris FC | 2.5 | 3–0 | 0.4 | Quevilly-Rouen | Stade Sébastien Charléty | Benjamin Lepaysant | Match Report | ||
| 24 | Sat | 2022-02-12 | 19:00 | Grenoble | 1.4 | 1–3 | 1.9 | Sochaux | 4,001 | Stade des Alpes | Abdelatif Kherradji | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Auxerre | 1.4 | 1–1 | 1.5 | Nancy | 5,003 | Stade de l'Abbé Deschamps | Marc Bollengier | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Amiens | 1.3 | 3–1 | 1.7 | Niort | 7,182 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Ajaccio | 0.1 | 0–1 | 0.5 | Guingamp | 3,200 | Stade François Coty | Pierre Legat | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Dijon | 1.1 | 0–1 | 0.8 | Pau FC | 6,465 | Stade Gaston Gérard | Gaël Angoula | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Caen | 4.4 | 4–0 | 0.5 | Nîmes | 8,075 | Stade Michel d'Ornano | Olivier Thual | Match Report | |
| 24 | Sat | 2022-02-12 | 19:00 | Dunkerque | 0.8 | 2–0 | 0.6 | Rodez Aveyron | 2,200 | Stade Marcel-Tribut | Hakim Ben El Hadj Salem | Match Report | |
| 24 | Mon | 2022-02-14 | 20:45 | Le Havre | 2.6 | 2–4 | 1.1 | Bastia | 4,464 | Stade Océane | Jérôme Miguelgorry | Match Report | |
| 22 | Tue | 2022-02-15 | 19:00 | Grenoble | 0.6 | 1–0 | 1.3 | Niort | 3,025 | Stade Lesdiguières | Mikael Lesage | Match Report | |
| 25 | Sat | 2022-02-19 | 15:00 | Sochaux | 1.3 | 0–1 | 1.1 | Ajaccio | 12,067 | Stade Auguste-Bonal | Thomas Léonard | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Rodez Aveyron | 0.9 | 1–1 | 1.0 | Amiens | 1,068 | Stade Paul Lignon | Arnaud Baert | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Nîmes | 3.7 | 3–1 | 0.7 | Grenoble | 1,492 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Quevilly-Rouen | 0.4 | 1–1 | 1.3 | Valenciennes | 2,777 | Stade Robert Diochon | Guillaume Paradis | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Niort | 1.1 | 0–1 | 0.9 | Auxerre | 2,128 | Stade René Gaillard | Franck Schneider | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Nancy | 1.5 | 2–0 | 0.9 | Dunkerque | 3,412 | Stade Marcel Picot | Aurélien Petit | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Guingamp | 0.6 | 1–1 | 1.6 | Paris FC | 8,284 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Pau FC | 0.5 | 1–0 | 1.5 | Caen | 3,106 | Stade Nouste Camp | Nicolas Rainville | Match Report | |
| 25 | Sat | 2022-02-19 | 19:00 | Bastia | 0.9 | 0–0 | 0.6 | Dijon | 8,500 | Stade Armand Césari | Remi Landry | Match Report | |
| 25 | Mon | 2022-02-21 | 20:45 | Toulouse | 2.3 | 4–0 | 0.3 | Le Havre | 11,130 | Stadium Municipal | Mathieu Vernice | Match Report | |
| 26 | Sat | 2022-02-26 | 15:00 | Paris FC | 0.7 | 3–1 | 1.0 | Sochaux | 2,766 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Auxerre | 1.3 | 1–0 | 0.6 | Quevilly-Rouen | 5,214 | Stade de l'Abbé Deschamps | Remi Landry | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Valenciennes | 1.4 | 1–0 | 0.5 | Pau FC | 6,445 | Stade Nungesser | Benjamin Lepaysant | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Guingamp | 1.3 | 1–0 | 0.3 | Niort | 7,368 | Stade du Roudourou | Gaël Angoula | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Dunkerque | 0.8 | 2–1 | 1.5 | Dijon | 2,200 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Caen | 1.6 | 2–1 | 0.6 | Bastia | 8,980 | Stade Michel d'Ornano | Johan Hamel | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Le Havre | 1.6 | 1–0 | 0.4 | Nancy | 4,383 | Stade Municipal Jules Deschaseaux | Bartolomeu Varela | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Ajaccio | 1.0 | 2–1 | 0.9 | Rodez Aveyron | 2,500 | Stade François Coty | Mathieu Vernice | Match Report | |
| 26 | Sat | 2022-02-26 | 19:00 | Amiens | 1.3 | 3–0 | 1.0 | Nîmes | 7,354 | Stade Moulonguet | Marc Bollengier | Match Report | |
| 26 | Mon | 2022-02-28 | 20:45 | Grenoble | 1.0 | 0–2 | 1.8 | Toulouse | 4,501 | Stade Lesdiguières | Olivier Thual | Match Report | |
| 27 | Sat | 2022-03-05 | 15:00 | Nîmes | 1.3 | 1–1 | 1.2 | Paris FC | 2,008 | Stade des Costières | Mathieu Vernice | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Dijon | 0.5 | 1–0 | 1.0 | Caen | 4,500 | Stade Gaston Gérard | Franck Schneider | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Bastia | 0.7 | 1–1 | 0.9 | Valenciennes | 8,000 | Stade Armand Césari | Jérôme Brisard | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Sochaux | 2.1 | 1–0 | 1.4 | Guingamp | 7,099 | Stade Auguste-Bonal | Alexandre Perreau Niel | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Pau FC | 1.4 | 2–1 | 1.4 | Amiens | 2,356 | Stade Nouste Camp | Pierre Legat | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Rodez Aveyron | 0.6 | 1–3 | 1.2 | Auxerre | 1,393 | Stade Paul Lignon | Jérôme Miguelgorry | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Nancy | 2.0 | 0–1 | 0.3 | Grenoble | 7,000 | Stade Marcel Picot | Nicolas Rainville | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Quevilly-Rouen | 0.9 | 0–2 | 0.8 | Le Havre | 5,200 | Stade Robert Diochon | Marc Bollengier | Match Report | |
| 27 | Sat | 2022-03-05 | 19:00 | Niort | 0.1 | 0–1 | 1.2 | Ajaccio | 1,973 | Stade René Gaillard | Aurélien Petit | Match Report | |
| 27 | Mon | 2022-03-07 | 20:45 | Toulouse | 1.6 | 2–0 | 0.5 | Dunkerque | 8,955 | Stadium Municipal | Arnaud Baert | Match Report | |
| 28 | Sat | 2022-03-12 | 15:00 | Ajaccio | 0.6 | 0–1 | 0.2 | Bastia | 5,000 | Stade François Coty | Hakim Ben El Hadj Salem | Match Report | |
| 28 | Sat | 2022-03-12 | 15:00 | Auxerre | 1.9 | 3–2 | 1.9 | Sochaux | 10,091 | Stade de l'Abbé Deschamps | Benjamin Lepaysant | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Caen | 1.6 | 4–1 | 0.9 | Toulouse | 11,429 | Stade Michel d'Ornano | Guillaume Paradis | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Paris FC | 2.0 | 2–0 | 0.6 | Niort | 2,636 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Grenoble | 0.3 | 0–0 | 0.4 | Rodez Aveyron | 3,889 | Stade des Alpes | Franck Schneider | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Amiens | 1.6 | 1–0 | 0.9 | Nancy | 7,500 | Stade Crédit Agricole la Licorne | Gaël Angoula | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Valenciennes | 0.7 | 0–0 | 0.2 | Dijon | 5,119 | Stade du Hainaut | Mathieu Vernice | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Le Havre | 1.1 | 0–1 | 0.9 | Nîmes | 4,407 | Stade Océane | Pierre Legat | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Guingamp | 0.5 | 1–1 | 0.8 | Quevilly-Rouen | 7,794 | Stade du Roudourou | Abdelatif Kherradji | Match Report | |
| 28 | Sat | 2022-03-12 | 19:00 | Dunkerque | 1.4 | 1–0 | 0.4 | Pau FC | 2,200 | Stade Marcel-Tribut | Bartolomeu Varela | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Niort | 1.4 | 1–1 | 1.0 | Sochaux | 1,802 | Stade René Gaillard | Nicolas Rainville | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Rodez Aveyron | 2.6 | 1–1 | 0.6 | Guingamp | 1,045 | Stade Paul Lignon | Arnaud Baert | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Quevilly-Rouen | 0.6 | 0–0 | 0.4 | Ajaccio | 2,689 | Stade Robert Diochon | Gaël Angoula | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Pau FC | 1.7 | 0–1 | 1.0 | Grenoble | 2,581 | Stade Nouste Camp | Mathieu Vernice | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Nîmes | 0.3 | 1–2 | 2.4 | Auxerre | 1,838 | Stade des Costières | Pierre Gaillouste | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Dijon | 1.0 | 2–0 | 0.5 | Le Havre | 4,500 | Stade Gaston Gérard | Aurélien Petit | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Toulouse | 4.7 | 6–0 | 0.7 | Amiens | 7,119 | Stadium Municipal | Remi Landry | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Valenciennes | 1.4 | 1–1 | 1.6 | Caen | 6,457 | Stade du Hainaut | Abdelatif Kherradji | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Nancy | 1.8 | 3–0 | 0.8 | Paris FC | 4,000 | Stade Marcel Picot | Jeremy Stinat | Match Report | |
| 29 | Tue | 2022-03-15 | 19:00 | Bastia | 1.2 | 1–0 | 0.4 | Dunkerque | 5,000 | Stade Armand Césari | Alexandre Perreau Niel | Match Report | |
| 30 | Sat | 2022-03-19 | 15:00 | Le Havre | 1.6 | 2–4 | 3.5 | Caen | 18,693 | Stade Océane | Mathieu Vernice | Match Report | |
| 30 | Sat | 2022-03-19 | 15:00 | Auxerre | 0.4 | 1–2 | 2.6 | Toulouse | 14,360 | Stade de l'Abbé Deschamps | Stéphanie Frappart | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Niort | 1.2 | 2–0 | 0.7 | Quevilly-Rouen | 1,800 | Stade René Gaillard | Benjamin Lepaysant | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Ajaccio | 2.5 | 1–0 | 0.8 | Nîmes | 2,300 | Stade François Coty | Olivier Thual | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Dunkerque | 1.3 | 1–2 | 0.8 | Valenciennes | 4,000 | Stade Marcel-Tribut | Franck Schneider | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Sochaux | 2.4 | 2–0 | 0.3 | Rodez Aveyron | 6,497 | Stade Auguste-Bonal | Bartolomeu Varela | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Paris FC | 1.7 | 1–1 | 1.6 | Pau FC | 3,275 | Stade Sébastien Charléty | Remi Landry | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Amiens | 2.1 | 1–1 | 0.6 | Dijon | 6,032 | Stade Crédit Agricole la Licorne | Guillaume Paradis | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Guingamp | 2.2 | 3–1 | 2.1 | Nancy | 8,666 | Stade du Roudourou | Jérôme Miguelgorry | Match Report | |
| 30 | Sat | 2022-03-19 | 19:00 | Grenoble | 0.9 | 1–1 | 1.4 | Bastia | 4,231 | Stade des Alpes | Pierre Legat | Match Report | |
| 31 | Sat | 2022-04-02 | 15:00 | Toulouse | 2.1 | 2–1 | 1.1 | Paris FC | 28,032 | Stadium Municipal | Aurélien Petit | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Dijon | 1.3 | 1–0 | 0.0 | Grenoble | 4,500 | Stade Gaston Gérard | Nicolas Rainville | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Bastia | 0.5 | 1–1 | 1.0 | Auxerre | 3,000 | Stade Armand Césari | Franck Schneider | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Valenciennes | 1.4 | 0–2 | 0.8 | Amiens | 5,450 | Stade Nungesser | Arnaud Baert | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Quevilly-Rouen | 0.7 | 0–2 | 1.5 | Sochaux | 2,000 | Stade Robert Diochon | Pierre Legat | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Caen | 1.1 | 2–1 | 0.9 | Dunkerque | 10,720 | Stade Michel d'Ornano | Willy Delajod | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Rodez Aveyron | 0.5 | 1–1 | 0.5 | Niort | 1,004 | Stade Paul Lignon | Abdelatif Kherradji | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Nîmes | 0.7 | 0–2 | 1.9 | Guingamp | 1,345 | Stade des Costières | Alexandre Perreau Niel | Match Report | |
| 31 | Sat | 2022-04-02 | 19:00 | Pau FC | 1.2 | 2–1 | 0.9 | Le Havre | 2,713 | Stade Nouste Camp | Gaël Angoula | Match Report | |
| 31 | Mon | 2022-04-04 | 20:45 | Nancy | 1.0 | 0–2 | 2.3 | Ajaccio | 3,000 | Stade Marcel Picot | Marc Bollengier | Match Report | |
| 32 | Sat | 2022-04-09 | 15:00 | Guingamp | 1.1 | 2–4 | 1.7 | Toulouse | 11,640 | Stade du Roudourou | Remi Landry | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Le Havre | 1.1 | 2–1 | 2.3 | Dunkerque | 4,332 | Stade Municipal Jules Deschaseaux | Bartolomeu Varela | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Ajaccio | 3.6 | 2–1 | 0.5 | Pau FC | 4,200 | Stade François Coty | Alexandre Perreau Niel | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Auxerre | 1.2 | 1–0 | 0.3 | Valenciennes | 11,447 | Stade de l'Abbé Deschamps | Gaël Angoula | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Sochaux | 1.3 | 1–0 | 0.9 | Nancy | 9,102 | Stade Auguste-Bonal | Guillaume Paradis | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Quevilly-Rouen | 1.1 | 2–0 | 1.8 | Rodez Aveyron | 4,568 | Stade Robert Diochon | Benoît Millot | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Niort | 1.4 | 0–0 | 0.4 | Nîmes | 2,000 | Stade René Gaillard | Marc Bollengier | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Amiens | 0.9 | 0–0 | 0.2 | Bastia | 2,697 | Stade Moulonguet | Benjamin Lepaysant | Match Report | |
| 32 | Sat | 2022-04-09 | 19:00 | Grenoble | 0.8 | 0–2 | 0.8 | Caen | 3,937 | Stade Lesdiguières | Jérôme Miguelgorry | Match Report | |
| 32 | Mon | 2022-04-11 | 20:45 | Paris FC | 1.3 | 2–2 | 1.4 | Dijon | 3,034 | Stade Sébastien Charléty | Olivier Thual | Match Report | |
| 33 | Sat | 2022-04-16 | 15:00 | Pau FC | 0.6 | 1–4 | 3.0 | Auxerre | 3,406 | Stade Nouste Camp | Aurélien Petit | Match Report | |
| 33 | Sat | 2022-04-16 | 15:00 | Toulouse | 3.0 | 2–0 | 1.2 | Quevilly-Rouen | 12,348 | Stadium Municipal | Romain Lissorgue | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Valenciennes | 0.8 | 0–1 | 1.5 | Le Havre | 10,000 | Stade du Hainaut | Pierre Legat | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Nancy | 1.1 | 0–2 | 1.4 | Niort | 3,000 | Stade Marcel Picot | Arnaud Baert | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Dunkerque | 0.6 | 0–3 | 1.9 | Grenoble | 2,300 | Stade Marcel-Tribut | Mathieu Vernice | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Nîmes | 1.9 | 1–3 | 2.2 | Sochaux | 1,694 | Stade des Costières | Mikael Lesage | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Dijon | 0.6 | 0–3 | 1.2 | Ajaccio | 7,466 | Stade Gaston Gérard | Abdelatif Kherradji | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Bastia | 0.6 | 1–2 | 1.6 | Guingamp | 6,000 | Stade Armand Césari | Nicolas Rainville | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Caen | 1.5 | 1–1 | 0.8 | Amiens | 11,263 | Stade Michel d'Ornano | Bartolomeu Varela | Match Report | |
| 33 | Sat | 2022-04-16 | 19:00 | Rodez Aveyron | 0.8 | 0–1 | 0.4 | Paris FC | 1,442 | Stade Paul Lignon | Franck Schneider | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Auxerre | 1.7 | 2–1 | 0.6 | Dijon | 13,614 | Stade de l'Abbé Deschamps | Marc Bollengier | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Niort | 1.2 | 1–1 | 1.5 | Bastia | 2,045 | Stade René Gaillard | Thomas Léonard | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Rodez Aveyron | 1.7 | 1–1 | 1.7 | Nancy | 1,607 | Stade Paul Lignon | Gaël Angoula | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Quevilly-Rouen | 1.2 | 0–1 | 0.7 | Nîmes | 3,334 | Stade Robert Diochon | Aurélien Petit | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Paris FC | 0.6 | 1–0 | 0.9 | Caen | 3,423 | Stade Sébastien Charléty | Remi Landry | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Ajaccio | 1.4 | 2–1 | 1.3 | Dunkerque | 4,300 | Stade François Coty | Nicolas Rainville | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Guingamp | 1.9 | 3–0 | 1.3 | Pau FC | 8,291 | Stade du Roudourou | Guillaume Paradis | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Grenoble | 1.9 | 3–0 | 0.4 | Valenciennes | 4,312 | Stade des Alpes | Olivier Thual | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Amiens | 1.0 | 0–2 | 1.8 | Le Havre | 6,574 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| 34 | Tue | 2022-04-19 | 20:00 | Sochaux | 0.7 | 1–1 | 2.7 | Toulouse | 15,188 | Stade Auguste-Bonal | Benjamin Lepaysant | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Nîmes | 1.0 | 3–2 | 2.0 | Rodez Aveyron | 1,560 | Stade des Costières | Mathieu Vernice | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Le Havre | 0.8 | 0–1 | 0.7 | Grenoble | 4,830 | Stade Océane | Arnaud Baert | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Dunkerque | 0.7 | 0–0 | 1.5 | Amiens | 3,400 | Stade Marcel-Tribut | Olivier Thual | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Dijon | 2.4 | 3–3 | 4.3 | Guingamp | 5,000 | Stade Gaston Gérard | Eric Wattellier | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Bastia | 1.3 | 2–1 | 1.9 | Paris FC | 6,000 | Stade Armand Césari | Abdelatif Kherradji | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Nancy | 0–3 | Quevilly-Rouen | Stade Marcel Picot | Remi Landry | Match Report | Match awarded to Quevilly-Rouen | |||
| 35 | Fri | 2022-04-22 | 21:00 | Valenciennes | 0.2 | 0–0 | 1.0 | Ajaccio | 15,451 | Stade du Hainaut | Franck Schneider | Match Report | |
| 35 | Fri | 2022-04-22 | 21:00 | Pau FC | 1.5 | 0–1 | 0.8 | Sochaux | 3,363 | Stade Nouste Camp | Bartolomeu Varela | Match Report | |
| 35 | Sat | 2022-04-23 | 15:00 | Caen | 1.1 | 1–1 | 1.0 | Auxerre | 14,935 | Stade Michel d'Ornano | Pierre Legat | Match Report | |
| 35 | Mon | 2022-04-25 | 20:45 | Toulouse | 2.3 | 2–0 | 0.2 | Niort | 24,209 | Stadium Municipal | Alexandre Perreau Niel | Match Report | |
| 36 | Sat | 2022-04-30 | 15:00 | Auxerre | 1.5 | 1–0 | 0.9 | Dunkerque | 10,714 | Stade de l'Abbé Deschamps | Benjamin Lepaysant | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Grenoble | 1.7 | 1–1 | 1.1 | Amiens | 4,710 | Stade des Alpes | Gaël Angoula | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Guingamp | 2.6 | 2–1 | 1.0 | Caen | 10,950 | Stade du Roudourou | Arnaud Baert | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Ajaccio | 1.1 | 2–1 | 0.4 | Le Havre | 4,900 | Stade François Coty | Aurélien Petit | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Sochaux | 0.4 | 2–1 | 0.2 | Bastia | 14,005 | Stade Auguste-Bonal | Marc Bollengier | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Niort | 1.8 | 1–3 | 3.7 | Dijon | 2,000 | Stade René Gaillard | Pierre Legat | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Nancy | 2.9 | 1–3 | 1.5 | Nîmes | Stade Marcel Picot | Bartolomeu Varela | Match Report | ||
| 36 | Sat | 2022-04-30 | 19:00 | Paris FC | 0.8 | 1–1 | 2.3 | Valenciennes | 4,017 | Stade Sébastien Charléty | Guillaume Paradis | Match Report | |
| 36 | Sat | 2022-04-30 | 19:00 | Quevilly-Rouen | 0.7 | 1–2 | 1.2 | Pau FC | 3,708 | Stade Robert Diochon | Nicolas Rainville | Match Report | |
| 36 | Mon | 2022-05-02 | 20:45 | Rodez Aveyron | 1.4 | 1–0 | 1.8 | Toulouse | 5,955 | Stade Paul Lignon | Florent Batta | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Valenciennes | 1.2 | 1–0 | 0.8 | Sochaux | 22,250 | Stade du Hainaut | Jeremy Stinat | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Pau FC | 2.3 | 2–2 | 1.4 | Niort | 3,518 | Stade Nouste Camp | Remi Landry | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Toulouse | 2.6 | 2–1 | 0.5 | Nîmes | 27,868 | Stadium Municipal | Jérôme Miguelgorry | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Le Havre | 1.9 | 1–2 | 2.3 | Auxerre | 8,058 | Stade Océane | Nicolas Rainville | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Caen | 0.9 | 2–0 | 1.2 | Quevilly-Rouen | 18,003 | Stade Michel d'Ornano | Franck Schneider | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Bastia | 0.7 | 0–1 | 1.4 | Rodez Aveyron | 8,000 | Stade Armand Césari | Pierre Legat | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Grenoble | 0.3 | 1–1 | 1.1 | Ajaccio | 5,673 | Stade des Alpes | Mathieu Vernice | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Amiens | 1.6 | 1–2 | 1.1 | Paris FC | 12,999 | Stade Crédit Agricole la Licorne | Alexandre Perreau Niel | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Dunkerque | 2.6 | 1–3 | 1.1 | Guingamp | 3,500 | Stade Marcel-Tribut | Abdelatif Kherradji | Match Report | |
| 37 | Sat | 2022-05-07 | 19:00 | Dijon | 1.4 | 2–3 | 1.1 | Nancy | 7,500 | Stade Gaston Gérard | Olivier Thual | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Auxerre | 1.7 | 2–1 | 0.6 | Amiens | 17,051 | Stade de l'Abbé Deschamps | Aurélien Petit | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Paris FC | 1.6 | 2–0 | 0.5 | Grenoble | 6,592 | Stade Sébastien Charléty | Marc Bollengier | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Quevilly-Rouen | 2.5 | 3–1 | 0.9 | Dunkerque | 4,078 | Stade Robert Diochon | Olivier Thual | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Rodez Aveyron | 1.1 | 2–0 | 1.1 | Caen | 1,667 | Stade Paul Lignon | Pierre Gaillouste | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Sochaux | 1.4 | 2–2 | 1.2 | Dijon | 19,019 | Stade Auguste-Bonal | Franck Schneider | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Nancy | 1.2 | 2–3 | 2.6 | Pau FC | 1,500 | Stade Marcel Picot | Arnaud Baert | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Nîmes | 0.4 | 0–2 | 1.2 | Bastia | 2,194 | Stade des Costières | Benjamin Lepaysant | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Ajaccio | 2.1 | 1–0 | 0.6 | Toulouse | 8,516 | Stade François Coty | Bastien Dechepy | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Guingamp | 2.2 | 2–1 | 1.3 | Le Havre | 12,834 | Stade du Roudourou | Amaury Delerue | Match Report | |
| 38 | Sat | 2022-05-14 | 19:00 | Niort | 1.3 | 1–2 | 2.0 | Valenciennes | 3,326 | Stade René Gaillard | Abdelatif Kherradji | Match Report |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tue | 2022-05-24 | 20:30 | Villefranche | 1–3 | Quevilly-Rouen | 3,200 | Stade Armand Chouffet | Match Report | Leg 1 of 2 | |||
| Sun | 2022-05-29 | 16:00 | Quevilly-Rouen | 2–0 | Villefranche | 4,500 | Stade Robert Diochon | Match Report | Leg 2 of 2; Quevilly-Rouen won |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thu | 2022-05-26 | 19:00 | Auxerre | 1–1 | Saint-Étienne | 17,479 | Stade de l'Abbé Deschamps | Match Report | Leg 1 of 2 | |||
| Sun | 2022-05-29 | 19:00 | Saint-Étienne | (4) 1–1 (5) | Auxerre | 24,489 | Stade Geoffroy-Guichard | Match Report | Leg 2 of 2; Auxerre won; Auxerre won on penalty kicks following extra time |
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