Scores & Fixtures 2021-2022 Belgian First Division A
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-07-23 | 20:45 | Standard Liège | 0.8 | 1–1 | 2.2 | Genk | 9,200 | Stade Maurice Dufrasne | Lawrence Visser | Match Report | |
| 1 | Sat | 2021-07-24 | 16:15 | OH Leuven | 2.5 | 1–1 | 1.1 | Zulte Waregem | 3,300 | King Power at Den Dreef Stadion | Bert Put | Match Report | |
| 1 | Sat | 2021-07-24 | 18:30 | Kortrijk | 1.4 | 2–0 | 0.7 | R.F.C. Seraing | 2,744 | Guldensporenstadion | Christof Dierick | Match Report | |
| 1 | Sat | 2021-07-24 | 20:45 | Oostende | 0.7 | 0–3 | 1.5 | Charleroi | 2,800 | Diaz Arena | Erik Lambrechts | Match Report | |
| 1 | Sun | 2021-07-25 | 13:30 | Mechelen | 1.7 | 3–2 | 0.6 | Antwerp | 4,800 | AFAS-stadion Achter de Kazerne | Nicolas Laforge | Match Report | |
| 1 | Sun | 2021-07-25 | 16:00 | Club Brugge | 3.0 | 2–2 | 1.7 | Eupen | 10,000 | Jan Breydelstadion | Bram Van Driessche | Match Report | |
| 1 | Sun | 2021-07-25 | 18:30 | Anderlecht | 1.5 | 1–3 | 1.4 | Union SG | 6,000 | Lotto Park | Kevin Van Damme | Match Report | |
| 1 | Sun | 2021-07-25 | 21:00 | Sint-Truiden | 0.8 | 2–1 | 1.1 | Gent | 2,000 | Stayen | Jan Boterberg | Match Report | |
| 1 | Tue | 2021-07-27 | 20:00 | Beerschot | 0.8 | 0–1 | 0.4 | Cercle Brugge | 3,800 | Olympisch Stadion | Alexandre Boucaut | Match Report | |
| 2 | Fri | 2021-07-30 | 20:45 | Genk | 2.6 | 3–4 | 1.9 | Oostende | 5,069 | Luminus Arena | Nathan Verboomen | Match Report | |
| 2 | Sat | 2021-07-31 | 16:15 | Charleroi | 0.8 | 0–0 | 0.3 | Sint-Truiden | 4,648 | Stade du Pays de Charleroi | Lawrence Visser | Match Report | |
| 2 | Sat | 2021-07-31 | 18:30 | Cercle Brugge | 1.7 | 1–1 | 1.5 | OH Leuven | 2,500 | Jan Breydelstadion | Lothar D'Hondt | Match Report | |
| 2 | Sat | 2021-07-31 | 18:30 | R.F.C. Seraing | 1.7 | 1–0 | 1.0 | Mechelen | 1,684 | Stade du Pairay | Wesli De Cremer | Match Report | |
| 2 | Sat | 2021-07-31 | 20:45 | Eupen | 2.2 | 1–1 | 1.7 | Anderlecht | 1,442 | Stadion am Kehrweg | Jonathan Lardot | Match Report | |
| 2 | Sun | 2021-08-01 | 13:30 | Union SG | 1.3 | 0–1 | 0.9 | Club Brugge | 3,200 | Stade Joseph Mariën | Wim Smet | Match Report | |
| 2 | Sun | 2021-08-01 | 16:00 | Zulte Waregem | 1.8 | 1–2 | 2.3 | Standard Liège | 4,124 | Elindus Arena | Nicolas Laforge | Match Report | |
| 2 | Sun | 2021-08-01 | 18:30 | Gent | 2.0 | 2–2 | 1.2 | Beerschot | 5,250 | GHELAMCO-arena | Jasper Vergoote | Match Report | |
| 2 | Sun | 2021-08-01 | 21:00 | Antwerp | 1.0 | 0–1 | 1.3 | Kortrijk | 5,000 | Bosuilstadion | Erik Lambrechts | Match Report | |
| 3 | Fri | 2021-08-06 | 20:45 | Club Brugge | 1.9 | 1–1 | 0.4 | Cercle Brugge | 10,000 | Jan Breydelstadion | Kevin Van Damme | Match Report | |
| 3 | Sat | 2021-08-07 | 16:15 | Beerschot | 0.8 | 0–3 | 2.0 | Union SG | 3,000 | Olympisch Stadion | Jan Boterberg | Match Report | |
| 3 | Sat | 2021-08-07 | 18:30 | Sint-Truiden | 0.8 | 1–3 | 1.0 | Zulte Waregem | 2,700 | Stayen | Lothar D'Hondt | Match Report | |
| 3 | Sat | 2021-08-07 | 18:30 | Mechelen | 1.3 | 1–3 | 2.0 | Eupen | 4,800 | AFAS-stadion Achter de Kazerne | Christof Dierick | Match Report | |
| 3 | Sat | 2021-08-07 | 20:45 | Kortrijk | 0.8 | 1–2 | 2.1 | Genk | 2,800 | Guldensporenstadion | Nicolas Laforge | Match Report | |
| 3 | Sun | 2021-08-08 | 13:30 | Standard Liège | 1.9 | 2–5 | 2.9 | Antwerp | 8,038 | Stade Maurice Dufrasne | Bram Van Driessche | Match Report | |
| 3 | Sun | 2021-08-08 | 16:00 | OH Leuven | 1.3 | 1–1 | 1.5 | Charleroi | 3,300 | King Power at Den Dreef Stadion | Nathan Verboomen | Match Report | |
| 3 | Sun | 2021-08-08 | 18:30 | Anderlecht | 2.4 | 3–0 | 0.2 | R.F.C. Seraing | 6,000 | Lotto Park | Wim Smet | Match Report | |
| 3 | Sun | 2021-08-08 | 21:00 | Oostende | 0.9 | 1–0 | 1.6 | Gent | 2,443 | Diaz Arena | Alexandre Boucaut | Match Report | |
| 4 | Fri | 2021-08-13 | 20:45 | Charleroi | 1.7 | 1–1 | 0.9 | Antwerp | 6,921 | Stade du Pays de Charleroi | Jonathan Lardot | Match Report | |
| 4 | Sat | 2021-08-14 | 16:15 | Union SG | 2.2 | 2–0 | 0.1 | Kortrijk | 4,500 | Stade Joseph Mariën | Wesli De Cremer | Match Report | |
| 4 | Sat | 2021-08-14 | 18:30 | R.F.C. Seraing | 1.0 | 2–3 | 1.4 | Oostende | 1,000 | Stade du Pairay | Bert Put | Match Report | |
| 4 | Sat | 2021-08-14 | 18:30 | Eupen | 0.6 | 2–1 | 1.2 | Sint-Truiden | 1,335 | Stadion am Kehrweg | Bram Van Driessche | Match Report | |
| 4 | Sat | 2021-08-14 | 20:45 | Genk | 3.3 | 4–0 | 1.2 | OH Leuven | 10,147 | Luminus Arena | Kevin Van Damme | Match Report | |
| 4 | Sun | 2021-08-15 | 13:30 | Beerschot | 1.8 | 0–1 | 0.5 | Standard Liège | 4,000 | Olympisch Stadion | Alexandre Boucaut | Match Report | |
| 4 | Sun | 2021-08-15 | 16:00 | Gent | 3.0 | 2–0 | 0.2 | Mechelen | 14,604 | GHELAMCO-arena | Nathan Verboomen | Match Report | |
| 4 | Sun | 2021-08-15 | 18:30 | Cercle Brugge | 0.6 | 1–2 | 2.2 | Anderlecht | 3,000 | Jan Breydelstadion | Jasper Vergoote | Match Report | |
| 4 | Sun | 2021-08-15 | 21:00 | Zulte Waregem | 0.5 | 0–4 | 3.6 | Club Brugge | 4,580 | Elindus Arena | Lawrence Visser | Match Report | |
| 5 | Fri | 2021-08-20 | 20:45 | Standard Liège | 1.7 | 1–0 | 0.6 | Oostende | 16,261 | Stade Maurice Dufrasne | Lawrence Visser | Match Report | |
| 5 | Sat | 2021-08-21 | 16:15 | R.F.C. Seraing | 1.5 | 2–1 | 1.9 | Cercle Brugge | 1,200 | Stade du Pairay | Christof Dierick | Match Report | |
| 5 | Sat | 2021-08-21 | 18:30 | OH Leuven | 1.1 | 1–4 | 2.5 | Eupen | 5,000 | King Power at Den Dreef Stadion | Wim Smet | Match Report | |
| 5 | Sat | 2021-08-21 | 20:45 | Sint-Truiden | 1.4 | 0–2 | 1.1 | Kortrijk | 2,243 | Stayen | Kevin Van Damme | Match Report | |
| 5 | Sun | 2021-08-22 | 16:00 | Zulte Waregem | 1.2 | 2–2 | 2.2 | Charleroi | 6,043 | Elindus Arena | Erik Lambrechts | Match Report | |
| 5 | Sun | 2021-08-22 | 18:30 | Club Brugge | 2.4 | 3–2 | 0.5 | Beerschot | 26,000 | Jan Breydelstadion | Lothar D'Hondt | Match Report | |
| 5 | Sun | 2021-08-22 | 21:00 | Mechelen | 1.8 | 3–1 | 2.0 | Union SG | 12,652 | AFAS-stadion Achter de Kazerne | Bert Put | Match Report | |
| 6 | Fri | 2021-08-27 | 20:45 | Kortrijk | 0.5 | 2–2 | 1.3 | Mechelen | 3,493 | Guldensporenstadion | Alexandre Boucaut | Match Report | |
| 6 | Sat | 2021-08-28 | 16:15 | Charleroi | 1.1 | 5–2 | 0.3 | Beerschot | 5,022 | Stade du Pays de Charleroi | Christof Dierick | Match Report | |
| 6 | Sat | 2021-08-28 | 18:30 | Eupen | 0.9 | 1–2 | 0.9 | R.F.C. Seraing | 2,700 | Stadion am Kehrweg | Jasper Vergoote | Match Report | |
| 6 | Sat | 2021-08-28 | 18:30 | Cercle Brugge | 1.5 | 0–1 | 1.2 | Sint-Truiden | 2,200 | Jan Breydelstadion | Jan Boterberg | Match Report | |
| 6 | Sat | 2021-08-28 | 20:45 | Union SG | 1.9 | 4–0 | 0.4 | Standard Liège | 6,255 | Stade Joseph Mariën | Jonathan Lardot | Match Report | |
| 6 | Sun | 2021-08-29 | 13:30 | Gent | 1.0 | 6–1 | 0.7 | Club Brugge | 16,000 | GHELAMCO-arena | Erik Lambrechts | Match Report | |
| 6 | Sun | 2021-08-29 | 16:00 | Antwerp | 1.7 | 2–2 | 2.8 | OH Leuven | 10,223 | Bosuilstadion | Wesli De Cremer | Match Report | |
| 6 | Sun | 2021-08-29 | 18:30 | Genk | 1.4 | 1–0 | 1.4 | Anderlecht | 17,000 | Luminus Arena | Nicolas Laforge | Match Report | |
| 6 | Sun | 2021-08-29 | 21:00 | Oostende | 1.3 | 0–2 | 1.8 | Zulte Waregem | 3,300 | Diaz Arena | Bram Van Driessche | Match Report | |
| 7 | Fri | 2021-09-10 | 20:45 | Club Brugge | 4.6 | 3–0 | 0.6 | Oostende | 26,000 | Jan Breydelstadion | Nathan Verboomen | Match Report | |
| 7 | Sat | 2021-09-11 | 16:15 | Eupen | 1.6 | 0–1 | 1.9 | Antwerp | 2,016 | Stadion am Kehrweg | Kevin Van Damme | Match Report | |
| 7 | Sat | 2021-09-11 | 18:30 | Zulte Waregem | 0.3 | 2–4 | 2.5 | Cercle Brugge | 6,200 | Elindus Arena | Alexandre Boucaut | Match Report | |
| 7 | Sun | 2021-09-12 | 13:30 | Anderlecht | 4.2 | 7–2 | 0.7 | Mechelen | 19,500 | Lotto Park | Jonathan Lardot | Match Report | |
| 7 | Sun | 2021-09-12 | 16:00 | Gent | 2.5 | 2–3 | 1.5 | Charleroi | 16,379 | GHELAMCO-arena | Lothar D'Hondt | Match Report | |
| 7 | Sun | 2021-09-12 | 18:30 | R.F.C. Seraing | 1.6 | 0–1 | 1.0 | Standard Liège | 7,000 | Stade du Pairay | Bram Van Driessche | Match Report | |
| 7 | Sun | 2021-09-12 | 21:00 | OH Leuven | 1.4 | 2–1 | 1.5 | Kortrijk | 3,200 | King Power at Den Dreef Stadion | Wim Smet | Match Report | |
| 7 | Sun | 2021-09-12 | 21:00 | Genk | 2.8 | 1–1 | 2.5 | Union SG | 14,000 | Luminus Arena | Erik Lambrechts | Match Report | |
| 7 | Mon | 2021-09-13 | 20:00 | Beerschot | 1.2 | 0–1 | 0.4 | Sint-Truiden | 8,500 | Olympisch Stadion | Bert Put | Match Report | |
| 8 | Fri | 2021-09-17 | 20:45 | Cercle Brugge | 0.9 | 1–2 | 1.1 | Eupen | 3,551 | Jan Breydelstadion | Bert Put | Match Report | |
| 8 | Sat | 2021-09-18 | 16:15 | Oostende | 3.3 | 3–1 | 1.3 | Beerschot | 3,010 | Diaz Arena | Wesli De Cremer | Match Report | |
| 8 | Sat | 2021-09-18 | 18:30 | Union SG | 1.9 | 2–1 | 0.8 | Zulte Waregem | 6,000 | Stade Joseph Mariën | Christof Dierick | Match Report | |
| 8 | Sat | 2021-09-18 | 18:30 | Mechelen | 0.4 | 2–0 | 1.1 | OH Leuven | 13,547 | AFAS-stadion Achter de Kazerne | Lawrence Visser | Match Report | |
| 8 | Sat | 2021-09-18 | 20:45 | Charleroi | 1.8 | 0–1 | 1.4 | Club Brugge | 8,554 | Stade du Pays de Charleroi | Jonathan Lardot | Match Report | |
| 8 | Sun | 2021-09-19 | 13:30 | Sint-Truiden | 1.6 | 1–2 | 1.4 | Genk | 6,000 | Stayen | Lothar D'Hondt | Match Report | |
| 8 | Sun | 2021-09-19 | 16:00 | Antwerp | 1.6 | 2–1 | 1.4 | R.F.C. Seraing | 10,177 | Bosuilstadion | Jan Boterberg | Match Report | |
| 8 | Sun | 2021-09-19 | 18:30 | Standard Liège | 0.5 | 0–1 | 1.2 | Anderlecht | 24,000 | Stade Maurice Dufrasne | Nicolas Laforge | Match Report | |
| 8 | Sun | 2021-09-19 | 21:00 | Kortrijk | 1.2 | 1–0 | 1.9 | Gent | 5,053 | Guldensporenstadion | Jasper Vergoote | Match Report | |
| 5 | Wed | 2021-09-22 | 20:45 | Antwerp | 2.2 | 4–2 | 2.3 | Genk | 15,600 | Bosuilstadion | Bram Van Driessche | Match Report | |
| 5 | Thu | 2021-09-23 | 20:45 | Anderlecht | 1.6 | 1–1 | 0.8 | Gent | 19,000 | Lotto Park | Erik Lambrechts | Match Report | |
| 9 | Fri | 2021-09-24 | 20:45 | Club Brugge | 3.4 | 1–1 | 0.3 | OH Leuven | 26,000 | Jan Breydelstadion | Jasper Vergoote | Match Report | |
| 9 | Sat | 2021-09-25 | 16:15 | Beerschot | 0.4 | 0–3 | 1.8 | Eupen | 7,500 | Olympisch Stadion | Nathan Verboomen | Match Report | |
| 9 | Sat | 2021-09-25 | 18:30 | Zulte Waregem | 1.4 | 2–2 | 1.3 | Kortrijk | 8,231 | Elindus Arena | Jan Boterberg | Match Report | |
| 9 | Sat | 2021-09-25 | 20:45 | Standard Liège | 0.5 | 1–2 | 1.0 | Sint-Truiden | 20,456 | Stade Maurice Dufrasne | Wim Smet | Match Report | |
| 9 | Sun | 2021-09-26 | 13:30 | Union SG | 1.7 | 1–2 | 0.9 | Antwerp | 6,800 | Stade Joseph Mariën | Nicolas Laforge | Match Report | |
| 9 | Sun | 2021-09-26 | 16:00 | Gent | 1.6 | 2–1 | 1.8 | Cercle Brugge | 16,391 | GHELAMCO-arena | Christof Dierick | Match Report | |
| 9 | Sun | 2021-09-26 | 18:30 | Oostende | 1.8 | 2–2 | 3.3 | Anderlecht | 5,008 | Diaz Arena | Lothar D'Hondt | Match Report | |
| 9 | Sun | 2021-09-26 | 21:00 | Genk | 3.3 | 3–0 | 0.2 | R.F.C. Seraing | 13,932 | Luminus Arena | Jonathan Lardot | Match Report | |
| 9 | Sun | 2021-09-26 | 21:00 | Charleroi | 1.4 | 0–2 | 1.6 | Mechelen | 6,307 | Stade du Pays de Charleroi | Kevin Van Damme | Match Report | |
| 10 | Fri | 2021-10-01 | 20:45 | Mechelen | 2.4 | 3–1 | 1.3 | Standard Liège | 15,067 | AFAS-stadion Achter de Kazerne | Nathan Verboomen | Match Report | |
| 10 | Sat | 2021-10-02 | 16:15 | Kortrijk | 2.4 | 2–2 | 3.1 | Charleroi | 4,494 | Guldensporenstadion | Bram Van Driessche | Match Report | |
| 10 | Sat | 2021-10-02 | 18:30 | Sint-Truiden | 1.7 | 1–1 | 0.6 | Oostende | 2,500 | Stayen | Jan Boterberg | Match Report | |
| 10 | Sat | 2021-10-02 | 18:30 | Cercle Brugge | 0.5 | 0–3 | 1.2 | Union SG | 2,850 | Jan Breydelstadion | Wesli De Cremer | Match Report | |
| 10 | Sat | 2021-10-02 | 20:45 | OH Leuven | 1.5 | 0–0 | 0.6 | Beerschot | 5,200 | King Power at Den Dreef Stadion | Erik Lambrechts | Match Report | |
| 10 | Sun | 2021-10-03 | 13:30 | Anderlecht | 1.6 | 1–1 | 0.8 | Club Brugge | 19,500 | Lotto Park | Lawrence Visser | Match Report | |
| 10 | Sun | 2021-10-03 | 16:00 | R.F.C. Seraing | 4.8 | 5–1 | 0.7 | Zulte Waregem | 2,500 | Stade du Pairay | Wim Smet | Match Report | |
| 10 | Sun | 2021-10-03 | 18:30 | Antwerp | 1.2 | 1–0 | 1.4 | Gent | 14,706 | Bosuilstadion | Alexandre Boucaut | Match Report | |
| 10 | Sun | 2021-10-03 | 21:00 | Eupen | 1.6 | 3–2 | 1.2 | Genk | 2,500 | Stadion am Kehrweg | Bert Put | Match Report | |
| 11 | Fri | 2021-10-15 | 20:45 | Club Brugge | 1.1 | 2–0 | 1.4 | Kortrijk | 26,352 | Jan Breydelstadion | Bert Put | Match Report | |
| 11 | Sat | 2021-10-16 | 16:15 | Union SG | 2.5 | 4–2 | 1.2 | R.F.C. Seraing | 7,000 | Stade Joseph Mariën | Nathan Verboomen | Match Report | |
| 11 | Sat | 2021-10-16 | 18:30 | Oostende | 1.3 | 2–1 | 1.1 | Cercle Brugge | 4,132 | Diaz Arena | Wim Smet | Match Report | |
| 11 | Sat | 2021-10-16 | 18:30 | Zulte Waregem | 1.1 | 2–1 | 1.1 | Antwerp | 7,182 | Elindus Arena | Jonathan Lardot | Match Report | |
| 11 | Sat | 2021-10-16 | 20:45 | Standard Liège | 2.0 | 2–2 | 1.9 | OH Leuven | 18,645 | Stade Maurice Dufrasne | Kevin Van Damme | Match Report | |
| 11 | Sun | 2021-10-17 | 13:30 | Sint-Truiden | 2.5 | 2–2 | 2.6 | Anderlecht | 6,500 | Stayen | Alexandre Boucaut | Match Report | |
| 11 | Sun | 2021-10-17 | 16:00 | Beerschot | 1.4 | 0–1 | 1.6 | Mechelen | 7,500 | Olympisch Stadion | Lothar D'Hondt | Match Report | |
| 11 | Sun | 2021-10-17 | 18:30 | Charleroi | 1.5 | 2–0 | 1.9 | Genk | 9,926 | Stade du Pays de Charleroi | Lawrence Visser | Match Report | |
| 11 | Sun | 2021-10-17 | 21:00 | Gent | 4.3 | 2–0 | 0.4 | Eupen | 16,125 | GHELAMCO-arena | Nicolas Laforge | Match Report | |
| 12 | Fri | 2021-10-22 | 20:45 | R.F.C. Seraing | 0.9 | 1–3 | 2.9 | Charleroi | 5,120 | Stade du Pairay | Wesli De Cremer | Match Report | |
| 12 | Sat | 2021-10-23 | 16:15 | Cercle Brugge | 1.5 | 1–1 | 0.7 | Standard Liège | 3,552 | Jan Breydelstadion | Jan Boterberg | Match Report | |
| 12 | Sat | 2021-10-23 | 18:30 | Mechelen | 2.2 | 2–2 | 0.9 | Zulte Waregem | 14,625 | AFAS-stadion Achter de Kazerne | Jasper Vergoote | Match Report | |
| 12 | Sat | 2021-10-23 | 18:30 | Kortrijk | 2.7 | 1–0 | 1.3 | Oostende | 3,357 | Guldensporenstadion | Jonathan Lardot | Match Report | |
| 12 | Sat | 2021-10-23 | 20:45 | Eupen | 1.8 | 2–3 | 1.8 | Union SG | 2,970 | Stadion am Kehrweg | Bram Van Driessche | Match Report | |
| 12 | Sun | 2021-10-24 | 13:30 | Antwerp | 0.8 | 1–1 | 1.4 | Club Brugge | 15,734 | Bosuilstadion | Nathan Verboomen | Match Report | |
| 12 | Sun | 2021-10-24 | 16:00 | Anderlecht | 3.4 | 4–2 | 1.1 | Beerschot | 20,000 | Lotto Park | Christof Dierick | Match Report | |
| 12 | Sun | 2021-10-24 | 18:30 | Genk | 2.3 | 0–3 | 2.6 | Gent | 15,296 | Luminus Arena | Erik Lambrechts | Match Report | |
| 12 | Sun | 2021-10-24 | 21:00 | OH Leuven | 2.2 | 4–1 | 1.0 | Sint-Truiden | 5,100 | King Power at Den Dreef Stadion | Nicolas Laforge | Match Report | |
| 13 | Fri | 2021-10-29 | 20:45 | Oostende | 1.0 | 2–4 | 1.8 | Mechelen | 3,881 | Diaz Arena | Christof Dierick | Match Report | |
| 13 | Sat | 2021-10-30 | 16:15 | Charleroi | 3.4 | 3–0 | 0.9 | Eupen | 5,328 | Stade du Pays de Charleroi | Bert Put | Match Report | |
| 13 | Sat | 2021-10-30 | 18:30 | Beerschot | 2.9 | 3–0 | 0.5 | R.F.C. Seraing | 6,500 | Olympisch Stadion | Kevin Van Damme | Match Report | |
| 13 | Sat | 2021-10-30 | 18:30 | Standard Liège | 0.8 | 1–1 | 0.7 | Kortrijk | 16,852 | Stade Maurice Dufrasne | Erik Lambrechts | Match Report | |
| 13 | Sat | 2021-10-30 | 20:45 | Sint-Truiden | 0.6 | 1–2 | 1.6 | Club Brugge | 6,000 | Stayen | Bram Van Driessche | Match Report | |
| 13 | Sun | 2021-10-31 | 13:30 | Zulte Waregem | 0.4 | 2–6 | 2.8 | Genk | 7,249 | Elindus Arena | Wim Smet | Match Report | |
| 13 | Sun | 2021-10-31 | 16:00 | Cercle Brugge | 0.7 | 0–1 | 1.3 | Antwerp | 3,273 | Jan Breydelstadion | Lothar D'Hondt | Match Report | |
| 13 | Sun | 2021-10-31 | 18:30 | Anderlecht | 1.7 | 2–2 | 1.9 | OH Leuven | 19,000 | Lotto Park | Jasper Vergoote | Match Report | |
| 13 | Sun | 2021-10-31 | 21:00 | Gent | 1.4 | 0–2 | 1.8 | Union SG | 17,541 | GHELAMCO-arena | Lawrence Visser | Match Report | |
| 14 | Fri | 2021-11-05 | 20:45 | OH Leuven | 0.4 | 1–0 | 1.7 | Oostende | 5,540 | King Power at Den Dreef Stadion | Wesli De Cremer | Match Report | |
| 14 | Sat | 2021-11-06 | 16:15 | Eupen | 0.9 | 1–1 | 1.4 | Zulte Waregem | 1,872 | Stadion am Kehrweg | Nathan Verboomen | Match Report | |
| 14 | Sat | 2021-11-06 | 18:30 | Mechelen | 0.4 | 0–1 | 1.0 | Sint-Truiden | 14,668 | AFAS-stadion Achter de Kazerne | Jan Boterberg | Match Report | |
| 14 | Sat | 2021-11-06 | 18:30 | Kortrijk | 1.9 | 1–1 | 2.2 | Beerschot | 5,803 | Guldensporenstadion | Arthur Denil | Match Report | |
| 14 | Sat | 2021-11-06 | 20:45 | Union SG | 1.7 | 4–0 | 1.1 | Charleroi | 8,100 | Stade Joseph Mariën | Nicolas Laforge | Match Report | |
| 14 | Sun | 2021-11-07 | 13:30 | Club Brugge | 1.2 | 2–2 | 1.6 | Standard Liège | 26,305 | Jan Breydelstadion | Lothar D'Hondt | Match Report | |
| 14 | Sun | 2021-11-07 | 16:00 | R.F.C. Seraing | 0.6 | 0–0 | 0.6 | Gent | 1,500 | Stade du Pairay | Alexandre Boucaut | Match Report | |
| 14 | Sun | 2021-11-07 | 18:30 | Antwerp | 2.0 | 2–0 | 1.4 | Anderlecht | 15,000 | Bosuilstadion | Jonathan Lardot | Match Report | |
| 14 | Sun | 2021-11-07 | 21:00 | Genk | 1.4 | 1–1 | 2.1 | Cercle Brugge | 12,831 | Luminus Arena | Jasper Vergoote | Match Report | |
| 15 | Fri | 2021-11-19 | 20:45 | Mechelen | 1.3 | 2–1 | 2.4 | Club Brugge | 16,254 | AFAS-stadion Achter de Kazerne | Nathan Verboomen | Match Report | |
| 15 | Sat | 2021-11-20 | 16:15 | Cercle Brugge | 2.0 | 1–2 | 1.3 | Charleroi | 2,527 | Jan Breydelstadion | Lawrence Visser | Match Report | |
| 15 | Sat | 2021-11-20 | 18:30 | Zulte Waregem | 0.9 | 1–2 | 2.8 | Gent | 7,476 | Elindus Arena | Bert Put | Match Report | |
| 15 | Sat | 2021-11-20 | 18:30 | OH Leuven | 0.7 | 1–3 | 1.2 | R.F.C. Seraing | 4,767 | King Power at Den Dreef Stadion | Nicolas Laforge | Match Report | |
| 15 | Sat | 2021-11-20 | 20:45 | Standard Liège | 1.6 | 1–0 | 0.7 | Eupen | 16,341 | Stade Maurice Dufrasne | Jasper Vergoote | Match Report | |
| 15 | Sun | 2021-11-21 | 13:30 | Anderlecht | 1.6 | 1–1 | 1.3 | Kortrijk | 18,000 | Lotto Park | Wim Smet | Match Report | |
| 15 | Sun | 2021-11-21 | 16:00 | Sint-Truiden | 1.0 | 2–1 | 1.0 | Antwerp | 5,370 | Stayen | Erik Lambrechts | Match Report | |
| 15 | Sun | 2021-11-21 | 18:30 | Oostende | 0.9 | 1–7 | 4.0 | Union SG | 3,610 | Diaz Arena | Kevin Van Damme | Match Report | |
| 15 | Sun | 2021-11-21 | 21:00 | Beerschot | 1.2 | 2–0 | 1.6 | Genk | 8,000 | Olympisch Stadion | Alexandre Boucaut | Match Report | |
| 16 | Fri | 2021-11-26 | 20:45 | Union SG | 1.0 | 1–3 | 0.8 | OH Leuven | 8,100 | Stade Joseph Mariën | Nathan Verboomen | Match Report | |
| 16 | Sat | 2021-11-27 | 16:15 | R.F.C. Seraing | 0.9 | 2–0 | 1.5 | Sint-Truiden | 1,200 | Stade du Pairay | Lothar D'Hondt | Match Report | |
| 16 | Sat | 2021-11-27 | 18:30 | Cercle Brugge | 3.3 | 3–1 | 0.3 | Mechelen | 2,870 | Jan Breydelstadion | Wesli De Cremer | Match Report | |
| 16 | Sat | 2021-11-27 | 18:30 | Eupen | 1.8 | 2–2 | 1.7 | Kortrijk | 1,650 | Stadion am Kehrweg | Jan Boterberg | Match Report | |
| 16 | Sat | 2021-11-27 | 20:45 | Charleroi | 0.5 | 1–3 | 1.8 | Anderlecht | 10,816 | Stade du Pays de Charleroi | Erik Lambrechts | Match Report | |
| 16 | Sun | 2021-11-28 | 13:30 | Genk | 1.0 | 2–3 | 0.9 | Club Brugge | 16,000 | Luminus Arena | Lawrence Visser | Match Report | |
| 16 | Sun | 2021-11-28 | 16:00 | Zulte Waregem | 1.7 | 2–0 | 1.7 | Beerschot | 4,949 | Elindus Arena | Bram Van Driessche | Match Report | |
| 16 | Sun | 2021-11-28 | 18:30 | Gent | 2.7 | 3–1 | 1.4 | Standard Liège | 18,120 | GHELAMCO-arena | Jonathan Lardot | Match Report | |
| 16 | Sun | 2021-11-28 | 21:00 | Antwerp | 1.9 | 3–0 | 0.1 | Oostende | 15,000 | Bosuilstadion | Christof Dierick | Match Report | |
| 17 | Fri | 2021-12-03 | 20:45 | Sint-Truiden | 0.7 | 1–2 | 2.3 | Union SG | 4,238 | Stayen | Jasper Vergoote | Match Report | |
| 17 | Sat | 2021-12-04 | 16:15 | OH Leuven | 1.6 | 0–1 | 1.4 | Gent | 4,047 | King Power at Den Dreef Stadion | Jan Boterberg | Match Report | |
| 17 | Sat | 2021-12-04 | 18:30 | Kortrijk | 0.7 | 0–2 | 3.5 | Cercle Brugge | 4,311 | Guldensporenstadion | Bert Put | Match Report | |
| 17 | Sat | 2021-12-04 | 18:30 | Oostende | 1.8 | 2–1 | 0.4 | Eupen | 1,730 | Diaz Arena | Wesli De Cremer | Match Report | |
| 17 | Sat | 2021-12-04 | 20:45 | Club Brugge | 3.7 | 3–2 | 2.0 | R.F.C. Seraing | 24,100 | Jan Breydelstadion | Alexandre Boucaut | Match Report | |
| 17 | Sun | 2021-12-05 | 13:30 | Beerschot | 0.9 | 0–1 | 1.0 | Antwerp | 11,000 | Olympisch Stadion | Lothar D'Hondt | Match Report | |
| 17 | Sun | 2021-12-05 | 16:00 | Anderlecht | 2.0 | 3–2 | 1.9 | Zulte Waregem | 18,000 | Lotto Park | Lawrence Visser | Match Report | |
| 17 | Sun | 2021-12-05 | 18:30 | Standard Liège | 1.4 | 0–3 | 2.4 | Charleroi | 22,512 | Stade Maurice Dufrasne | Nicolas Laforge | Match Report | |
| 17 | Sun | 2021-12-05 | 21:00 | Mechelen | 1.4 | 1–1 | 1.5 | Genk | 15,000 | AFAS-stadion Achter de Kazerne | Jonathan Lardot | Match Report | |
| 18 | Fri | 2021-12-10 | 20:45 | Charleroi | 2.1 | 1–0 | 1.1 | Oostende | 4,315 | Stade du Pays de Charleroi | Bert Put | Match Report | |
| 18 | Sat | 2021-12-11 | 16:15 | Kortrijk | 0.6 | 2–1 | 1.2 | OH Leuven | 4,321 | Guldensporenstadion | Jasper Vergoote | Match Report | |
| 18 | Sat | 2021-12-11 | 18:30 | Eupen | 1.5 | 1–0 | 1.4 | Beerschot | 1,200 | Stadion am Kehrweg | Erik Lambrechts | Match Report | |
| 18 | Sat | 2021-12-11 | 18:30 | Sint-Truiden | 1.2 | 1–2 | 1.3 | Cercle Brugge | 3,004 | Stayen | Kevin Van Damme | Match Report | |
| 18 | Sat | 2021-12-11 | 20:45 | R.F.C. Seraing | 0.2 | 0–5 | 3.3 | Anderlecht | 3,500 | Stade du Pairay | Jan Boterberg | Match Report | |
| 18 | Sun | 2021-12-12 | 13:30 | Antwerp | 1.3 | 2–3 | 1.2 | Standard Liège | 10,980 | Bosuilstadion | Lawrence Visser | Match Report | |
| 18 | Sun | 2021-12-12 | 16:00 | Union SG | 1.3 | 2–0 | 1.8 | Mechelen | 8,100 | Stade Joseph Mariën | Christof Dierick | Match Report | |
| 18 | Sun | 2021-12-12 | 18:30 | Gent | 0.9 | 1–0 | 1.2 | Genk | 16,448 | GHELAMCO-arena | Nathan Verboomen | Match Report | |
| 18 | Sun | 2021-12-12 | 21:00 | Club Brugge | 2.9 | 3–0 | 0.8 | Zulte Waregem | 16,323 | Jan Breydelstadion | Wim Smet | Match Report | |
| 19 | Tue | 2021-12-14 | 18:45 | Cercle Brugge | 0.8 | 2–0 | 0.7 | R.F.C. Seraing | 2,368 | Jan Breydelstadion | Brent Staessens | Match Report | |
| 19 | Tue | 2021-12-14 | 21:00 | Oostende | 0.8 | 0–2 | 0.8 | Kortrijk | 1,756 | Diaz Arena | Lothar D'Hondt | Match Report | |
| 19 | Tue | 2021-12-14 | 21:00 | Anderlecht | 3.0 | 2–0 | 0.6 | Sint-Truiden | 13,500 | Lotto Park | Jonathan Lardot | Match Report | |
| 19 | Wed | 2021-12-15 | 18:45 | Mechelen | 1.4 | 4–3 | 2.6 | Gent | 12,385 | AFAS-stadion Achter de Kazerne | Erik Lambrechts | Match Report | |
| 19 | Wed | 2021-12-15 | 18:45 | Zulte Waregem | 1.0 | 0–2 | 1.5 | Union SG | 5,804 | Elindus Arena | Nicolas Laforge | Match Report | |
| 19 | Wed | 2021-12-15 | 21:00 | OH Leuven | 1.3 | 1–4 | 2.1 | Club Brugge | 8,643 | King Power at Den Dreef Stadion | Lawrence Visser | Match Report | |
| 19 | Thu | 2021-12-16 | 18:45 | Antwerp | 1.5 | 4–2 | 1.4 | Eupen | 8,664 | Bosuilstadion | Alexandre Boucaut | Match Report | |
| 19 | Thu | 2021-12-16 | 21:00 | Genk | 2.0 | 4–2 | 0.8 | Charleroi | 10,043 | Luminus Arena | Bram Van Driessche | Match Report | |
| 20 | Fri | 2021-12-17 | 20:45 | R.F.C. Seraing | 0.4 | 0–2 | 1.2 | Kortrijk | 1,400 | Stade du Pairay | Wim Smet | Match Report | |
| 20 | Sat | 2021-12-18 | 16:15 | Beerschot | 1.3 | 0–2 | 1.6 | Oostende | 6,000 | Olympisch Stadion | Christof Dierick | Match Report | |
| 20 | Sat | 2021-12-18 | 18:30 | Zulte Waregem | 1.4 | 3–2 | 0.8 | Mechelen | 6,333 | Elindus Arena | Kevin Van Damme | Match Report | |
| 20 | Sat | 2021-12-18 | 18:30 | Union SG | 3.7 | 3–2 | 1.2 | Cercle Brugge | 7,114 | Stade Joseph Mariën | Jan Boterberg | Match Report | |
| 20 | Sat | 2021-12-18 | 20:45 | Gent | 1.2 | 2–1 | 0.9 | Sint-Truiden | 16,485 | GHELAMCO-arena | Lothar D'Hondt | Match Report | |
| 20 | Sun | 2021-12-19 | 13:30 | Club Brugge | 1.5 | 2–2 | 1.7 | Anderlecht | 28,000 | Jan Breydelstadion | Nathan Verboomen | Match Report | |
| 20 | Sun | 2021-12-19 | 16:00 | Eupen | 2.2 | 0–4 | 1.6 | Charleroi | 3,000 | Stadion am Kehrweg | Arthur Denil | Match Report | |
| 20 | Sun | 2021-12-19 | 18:30 | Genk | 1.6 | 1–1 | 0.7 | Antwerp | 14,253 | Luminus Arena | Nicolas Laforge | Match Report | |
| 20 | Sun | 2021-12-19 | 21:00 | OH Leuven | 0.9 | 2–1 | 1.7 | Standard Liège | 4,820 | King Power at Den Dreef Stadion | Alexandre Boucaut | Match Report | |
| 21 | Sun | 2021-12-26 | 13:30 | Cercle Brugge | 1.5 | 2–0 | 1.6 | Club Brugge | Jan Breydelstadion | Nicolas Laforge | Match Report | ||
| 21 | Sun | 2021-12-26 | 16:00 | Standard Liège | 2.6 | 0–1 | 0.5 | Zulte Waregem | Stade Maurice Dufrasne | Bert Put | Match Report | ||
| 21 | Sun | 2021-12-26 | 18:30 | Union SG | 0.9 | 0–0 | 0.8 | Gent | Stade Joseph Mariën | Lawrence Visser | Match Report | ||
| 21 | Sun | 2021-12-26 | 21:00 | Oostende | 0.3 | 0–4 | 3.4 | Genk | Diaz Arena | Jan Boterberg | Match Report | ||
| 21 | Mon | 2021-12-27 | 18:45 | Charleroi | 1.6 | 0–3 | 1.7 | OH Leuven | Stade du Pays de Charleroi | Kevin Van Damme | Match Report | ||
| 21 | Mon | 2021-12-27 | 18:45 | Mechelen | 1.6 | 2–0 | 1.6 | R.F.C. Seraing | AFAS-stadion Achter de Kazerne | Jasper Vergoote | Match Report | ||
| 21 | Mon | 2021-12-27 | 21:00 | Sint-Truiden | 1.3 | 2–0 | 0.6 | Eupen | Stayen | Bram Van Driessche | Match Report | ||
| 21 | Mon | 2021-12-27 | 21:00 | Beerschot | 0.5 | 0–7 | 3.7 | Anderlecht | Olympisch Stadion | Wim Smet | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:45 | Gent | 2.1 | 2–2 | 1.5 | Kortrijk | GHELAMCO-arena | Wim Smet | Match Report | ||
| 22 | Sat | 2022-01-15 | 16:15 | OH Leuven | 5–0 | Mechelen | King Power at Den Dreef Stadion | Nathan Verboomen | Match Report | Match awarded to OH Leuven | |||
| 22 | Sat | 2022-01-15 | 20:45 | Club Brugge | 2.7 | 2–0 | 0.2 | Sint-Truiden | Jan Breydelstadion | Erik Lambrechts | Match Report | ||
| 22 | Sun | 2022-01-16 | 13:30 | Antwerp | 3.0 | 3–0 | 1.1 | Charleroi | Bosuilstadion | Nicolas Laforge | Match Report | ||
| 22 | Sun | 2022-01-16 | 16:00 | Eupen | 0.2 | 0–2 | 2.3 | Cercle Brugge | Stadion am Kehrweg | Christof Dierick | Match Report | ||
| 22 | Sun | 2022-01-16 | 18:30 | Anderlecht | 1.6 | 1–1 | 0.5 | Standard Liège | Lotto Park | Bram Van Driessche | Match Report | ||
| 22 | Sun | 2022-01-16 | 21:00 | Genk | 4.0 | 4–1 | 0.9 | Beerschot | Luminus Arena | Lothar D'Hondt | Match Report | ||
| 22 | Tue | 2022-01-18 | 20:00 | R.F.C. Seraing | 1.3 | 0–4 | 2.6 | Union SG | Stade du Pairay | Wesli De Cremer | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:45 | Oostende | 0.9 | 1–2 | 1.8 | Antwerp | Diaz Arena | Bert Put | Match Report | ||
| 23 | Sat | 2022-01-22 | 16:15 | Kortrijk | 1.6 | 1–1 | 1.3 | Eupen | Guldensporenstadion | Lawrence Visser | Match Report | ||
| 23 | Sat | 2022-01-22 | 18:30 | Beerschot | 1.3 | 3–1 | 1.4 | OH Leuven | Olympisch Stadion | Kevin Van Damme | Match Report | ||
| 23 | Sat | 2022-01-22 | 18:30 | Sint-Truiden | 1.9 | 3–1 | 0.6 | R.F.C. Seraing | Stayen | Arthur Denil | Match Report | ||
| 23 | Sat | 2022-01-22 | 20:45 | Charleroi | 0.8 | 0–0 | 0.6 | Gent | Stade du Pays de Charleroi | Jasper Vergoote | Match Report | ||
| 23 | Sun | 2022-01-23 | 13:30 | Standard Liège | 1.0 | 2–2 | 2.4 | Club Brugge | Stade Maurice Dufrasne | Jonathan Lardot | Match Report | ||
| 23 | Sun | 2022-01-23 | 16:00 | Union SG | 1.4 | 2–1 | 1.1 | Genk | Stade Joseph Mariën | Nathan Verboomen | Match Report | ||
| 23 | Sun | 2022-01-23 | 18:30 | Mechelen | 0.1 | 0–1 | 1.1 | Anderlecht | AFAS-stadion Achter de Kazerne | Jan Boterberg | Match Report | ||
| 23 | Sun | 2022-01-23 | 21:00 | Cercle Brugge | 1.7 | 3–1 | 1.0 | Zulte Waregem | Jan Breydelstadion | Alexandre Boucaut | Match Report | ||
| 24 | Tue | 2022-01-25 | 18:45 | Antwerp | 1.1 | 1–1 | 1.0 | Sint-Truiden | Bosuilstadion | Kevin Van Damme | Match Report | ||
| 24 | Tue | 2022-01-25 | 21:00 | Charleroi | 1.6 | 1–1 | 0.4 | Kortrijk | Stade du Pays de Charleroi | Lothar D'Hondt | Match Report | ||
| 24 | Tue | 2022-01-25 | 21:00 | Gent | 2.0 | 1–1 | 1.1 | Oostende | GHELAMCO-arena | Brent Staessens | Match Report | ||
| 24 | Wed | 2022-01-26 | 18:45 | Zulte Waregem | 1.0 | 1–1 | 1.3 | OH Leuven | Elindus Arena | Nicolas Laforge | Match Report | ||
| 24 | Wed | 2022-01-26 | 18:45 | Eupen | 0.9 | 0–2 | 1.7 | Standard Liège | Stadion am Kehrweg | Wim Smet | Match Report | ||
| 24 | Wed | 2022-01-26 | 21:00 | Anderlecht | 0.5 | 0–2 | 1.4 | Cercle Brugge | Lotto Park | Wesli De Cremer | Match Report | ||
| 24 | Wed | 2022-01-26 | 21:00 | R.F.C. Seraing | 2.3 | 2–1 | 0.8 | Beerschot | Stade du Pairay | Bram Van Driessche | Match Report | ||
| 24 | Thu | 2022-01-27 | 20:45 | Club Brugge | 0.7 | 0–0 | 1.3 | Union SG | Jan Breydelstadion | Lawrence Visser | Match Report | ||
| 25 | Fri | 2022-01-28 | 20:45 | Sint-Truiden | 0.9 | 0–1 | 1.2 | Charleroi | 2,000 | Stayen | Jonathan Lardot | Match Report | |
| 25 | Sat | 2022-01-29 | 16:15 | Beerschot | 2.5 | 3–3 | 1.9 | Zulte Waregem | 2,500 | Olympisch Stadion | Bert Put | Match Report | |
| 25 | Sat | 2022-01-29 | 18:30 | R.F.C. Seraing | 2.1 | 0–0 | 1.1 | Eupen | 1,200 | Stade du Pairay | Kevin Van Damme | Match Report | |
| 25 | Sat | 2022-01-29 | 20:45 | Cercle Brugge | 0.6 | 0–1 | 0.5 | Oostende | 3,200 | Jan Breydelstadion | Arthur Denil | Match Report | |
| 25 | Sun | 2022-01-30 | 13:30 | Union SG | 0.4 | 1–0 | 0.6 | Anderlecht | 6,491 | Stade Joseph Mariën | Erik Lambrechts | Match Report | |
| 25 | Sun | 2022-01-30 | 16:00 | Gent | 1.6 | 0–1 | 0.9 | Antwerp | 15,954 | GHELAMCO-arena | Lothar D'Hondt | Match Report | |
| 25 | Sun | 2022-01-30 | 18:30 | Standard Liège | 1.2 | 1–2 | 0.8 | Mechelen | 10,286 | Stade Maurice Dufrasne | Bram Van Driessche | Match Report | |
| 25 | Sun | 2022-01-30 | 21:00 | Kortrijk | 0.9 | 0–1 | 3.2 | Club Brugge | 6,214 | Guldensporenstadion | Alexandre Boucaut | Match Report | |
| 21 | Wed | 2022-02-02 | 18:45 | Kortrijk | 2.7 | 0–2 | 0.8 | Antwerp | Guldensporenstadion | Jasper Vergoote | Match Report | ||
| 26 | Fri | 2022-02-04 | 20:45 | Charleroi | 1.2 | 2–0 | 0.5 | R.F.C. Seraing | 4,063 | Stade du Pays de Charleroi | Jan Boterberg | Match Report | |
| 26 | Sat | 2022-02-05 | 16:15 | Kortrijk | 1.6 | 1–3 | 1.8 | Sint-Truiden | 4,176 | Guldensporenstadion | Erik Lambrechts | Match Report | |
| 26 | Sat | 2022-02-05 | 18:30 | Standard Liège | 1.1 | 1–1 | 0.7 | Cercle Brugge | Stade Maurice Dufrasne | Lawrence Visser | Match Report | ||
| 26 | Sat | 2022-02-05 | 18:30 | Oostende | 0.6 | 1–3 | 1.5 | OH Leuven | 2,221 | Diaz Arena | Wim Smet | Match Report | |
| 26 | Sat | 2022-02-05 | 20:45 | Antwerp | 0.8 | 0–2 | 2.2 | Union SG | 10,000 | Bosuilstadion | Bram Van Driessche | Match Report | |
| 26 | Sun | 2022-02-06 | 13:30 | Club Brugge | 1.5 | 1–2 | 2.1 | Gent | 14,647 | Jan Breydelstadion | Nicolas Laforge | Match Report | |
| 26 | Sun | 2022-02-06 | 16:00 | Mechelen | 1.3 | 3–2 | 0.6 | Beerschot | 8,137 | AFAS-stadion Achter de Kazerne | Alexandre Boucaut | Match Report | |
| 26 | Sun | 2022-02-06 | 18:30 | Anderlecht | 4.7 | 4–1 | 2.2 | Eupen | 12,000 | Lotto Park | Nathan Verboomen | Match Report | |
| 26 | Sun | 2022-02-06 | 21:00 | Genk | 1.0 | 2–0 | 1.3 | Zulte Waregem | 10,012 | Luminus Arena | Jasper Vergoote | Match Report | |
| 22 | Wed | 2022-02-09 | 18:45 | Zulte Waregem | 1.2 | 0–0 | 2.2 | Oostende | 6,070 | Elindus Arena | Jonathan Lardot | Match Report | |
| 25 | Wed | 2022-02-09 | 21:00 | OH Leuven | 2.3 | 2–1 | 1.3 | Genk | 4,042 | King Power at Den Dreef Stadion | Bert Put | Match Report | |
| 27 | Fri | 2022-02-11 | 20:45 | R.F.C. Seraing | 0.6 | 0–1 | 2.6 | Antwerp | 2,544 | Stade du Pairay | Arthur Denil | Match Report | |
| 27 | Sat | 2022-02-12 | 16:15 | Eupen | 0.7 | 0–1 | 1.2 | Gent | 2,000 | Stadion am Kehrweg | Lawrence Visser | Match Report | |
| 27 | Sat | 2022-02-12 | 18:30 | Mechelen | 1.0 | 3–0 | 0.2 | Oostende | 8,000 | AFAS-stadion Achter de Kazerne | Nicolas Laforge | Match Report | |
| 27 | Sat | 2022-02-12 | 18:30 | OH Leuven | 1.6 | 3–2 | 2.1 | Cercle Brugge | 3,898 | King Power at Den Dreef Stadion | Alexandre Boucaut | Match Report | |
| 27 | Sat | 2022-02-12 | 20:45 | Zulte Waregem | 1.0 | 1–2 | 1.9 | Anderlecht | 7,445 | Elindus Arena | Jan Boterberg | Match Report | |
| 27 | Sun | 2022-02-13 | 13:30 | Genk | 1.7 | 2–0 | 1.4 | Standard Liège | 13,581 | Luminus Arena | Nathan Verboomen | Match Report | |
| 27 | Sun | 2022-02-13 | 16:00 | Union SG | 2.0 | 0–1 | 1.4 | Sint-Truiden | 7,491 | Stade Joseph Mariën | Bert Put | Match Report | |
| 27 | Sun | 2022-02-13 | 18:30 | Club Brugge | 1.8 | 2–0 | 1.2 | Charleroi | 15,000 | Jan Breydelstadion | Erik Lambrechts | Match Report | |
| 27 | Sun | 2022-02-13 | 21:00 | Beerschot | 0.8 | 2–1 | 1.0 | Kortrijk | 3,200 | Olympisch Stadion | Wesli De Cremer | Match Report | |
| 24 | Wed | 2022-02-16 | 18:45 | Genk | 3.5 | 4–1 | 0.5 | Mechelen | 10,719 | Luminus Arena | Jonathan Lardot | Match Report | |
| 28 | Sat | 2022-02-19 | 16:15 | Cercle Brugge | 2.7 | 2–0 | 0.3 | Beerschot | 3,872 | Jan Breydelstadion | Bert Put | Match Report | |
| 28 | Sat | 2022-02-19 | 18:30 | Oostende | 1.7 | 1–0 | 0.4 | Standard Liège | 3,267 | Diaz Arena | Erik Lambrechts | Match Report | |
| 28 | Sat | 2022-02-19 | 18:30 | Kortrijk | 3.7 | 5–0 | 1.3 | Zulte Waregem | 6,226 | Guldensporenstadion | Lawrence Visser | Match Report | |
| 28 | Sat | 2022-02-19 | 20:45 | Charleroi | 0.8 | 0–3 | 1.7 | Union SG | 7,118 | Stade du Pays de Charleroi | Nicolas Laforge | Match Report | |
| 28 | Sun | 2022-02-20 | 13:30 | Antwerp | 3.3 | 1–2 | 2.4 | Mechelen | 11,353 | Bosuilstadion | Lothar D'Hondt | Match Report | |
| 28 | Sun | 2022-02-20 | 16:00 | Eupen | 2.0 | 1–3 | 2.4 | Club Brugge | 3,087 | Stadion am Kehrweg | Jan Boterberg | Match Report | |
| 28 | Sun | 2022-02-20 | 18:30 | Anderlecht | 2.2 | 2–0 | 0.8 | Genk | 17,000 | Lotto Park | Bram Van Driessche | Match Report | |
| 28 | Sun | 2022-02-20 | 21:00 | Sint-Truiden | 1.4 | 2–0 | 0.9 | OH Leuven | 2,471 | Stayen | Jasper Vergoote | Match Report | |
| 28 | Wed | 2022-02-23 | 18:45 | Gent | 3.4 | 4–0 | 0.6 | R.F.C. Seraing | 16,469 | GHELAMCO-arena | Jasper Vergoote | Match Report | |
| 29 | Fri | 2022-02-25 | 20:45 | Beerschot | 1.3 | 2–3 | 1.7 | Charleroi | 3,500 | Olympisch Stadion | Alexandre Boucaut | Match Report | |
| 29 | Sat | 2022-02-26 | 16:15 | Union SG | 1.5 | 0–0 | 0.2 | Eupen | 7,600 | Stade Joseph Mariën | Wesli De Cremer | Match Report | |
| 29 | Sat | 2022-02-26 | 18:30 | Mechelen | 2.5 | 2–2 | 1.6 | Cercle Brugge | 9,889 | AFAS-stadion Achter de Kazerne | Bram Van Driessche | Match Report | |
| 29 | Sat | 2022-02-26 | 18:30 | Oostende | 0.9 | 0–0 | 0.6 | Sint-Truiden | 3,360 | Diaz Arena | Kevin Van Damme | Match Report | |
| 29 | Sat | 2022-02-26 | 20:45 | OH Leuven | 1.4 | 0–0 | 2.4 | Anderlecht | 7,801 | King Power at Den Dreef Stadion | Erik Lambrechts | Match Report | |
| 29 | Sun | 2022-02-27 | 13:30 | Club Brugge | 2.2 | 4–1 | 0.8 | Antwerp | 23,157 | Jan Breydelstadion | Lawrence Visser | Match Report | |
| 29 | Sun | 2022-02-27 | 16:00 | Genk | 3.7 | 2–0 | 1.1 | Kortrijk | 13,834 | Luminus Arena | Lothar D'Hondt | Match Report | |
| 29 | Sun | 2022-02-27 | 18:30 | Standard Liège | 0.9 | 0–1 | 1.4 | Gent | Stade Maurice Dufrasne | Jonathan Lardot | Match Report | ||
| 29 | Sun | 2022-02-27 | 21:00 | Zulte Waregem | 1.6 | 1–0 | 1.9 | R.F.C. Seraing | 6,640 | Elindus Arena | Nathan Verboomen | Match Report | |
| 19 | Wed | 2022-03-02 | 18:45 | Standard Liège | 1.3 | 1–0 | 1.1 | Beerschot | 9,423 | Stade Maurice Dufrasne | Christof Dierick | Match Report | |
| 30 | Fri | 2022-03-04 | 20:45 | Sint-Truiden | 0.7 | 1–1 | 0.8 | Mechelen | 4,628 | Stayen | Bert Put | Match Report | |
| 30 | Sat | 2022-03-05 | 16:15 | Cercle Brugge | 2.4 | 2–2 | 1.9 | Genk | 4,205 | Jan Breydelstadion | Erik Lambrechts | Match Report | |
| 30 | Sat | 2022-03-05 | 18:30 | Kortrijk | 0.8 | 2–3 | 2.2 | Union SG | 6,682 | Guldensporenstadion | Jan Boterberg | Match Report | |
| 30 | Sat | 2022-03-05 | 20:45 | R.F.C. Seraing | 0.3 | 0–5 | 2.1 | Club Brugge | 2,400 | Stade du Pairay | Bram Van Driessche | Match Report | |
| 30 | Sun | 2022-03-06 | 13:30 | Antwerp | 0.8 | 2–1 | 0.5 | Beerschot | 16,144 | Bosuilstadion | Nathan Verboomen | Match Report | |
| 30 | Sun | 2022-03-06 | 16:00 | Anderlecht | 1.6 | 3–0 | 0.9 | Oostende | 9,000 | Lotto Park | Wesli De Cremer | Match Report | |
| 30 | Sun | 2022-03-06 | 18:30 | Charleroi | 0.8 | 0–0 | 0.9 | Standard Liège | 11,503 | Stade du Pays de Charleroi | Jasper Vergoote | Match Report | |
| 30 | Sun | 2022-03-06 | 21:00 | Eupen | 2.0 | 3–1 | 1.3 | OH Leuven | 1,200 | Stadion am Kehrweg | Kevin Van Damme | Match Report | |
| 30 | Sun | 2022-03-06 | 21:00 | Gent | 3.1 | 2–1 | 0.8 | Zulte Waregem | 15,000 | GHELAMCO-arena | Nicolas Laforge | Match Report | |
| 31 | Fri | 2022-03-11 | 20:45 | OH Leuven | 1.5 | 1–4 | 3.0 | Union SG | 7,123 | King Power at Den Dreef Stadion | Jonathan Lardot | Match Report | |
| 31 | Sat | 2022-03-12 | 16:15 | Mechelen | 1.3 | 2–2 | 2.0 | Charleroi | 10,125 | AFAS-stadion Achter de Kazerne | Jan Boterberg | Match Report | |
| 31 | Sat | 2022-03-12 | 18:30 | Cercle Brugge | 3.1 | 2–0 | 0.4 | Kortrijk | 4,000 | Jan Breydelstadion | Nathan Verboomen | Match Report | |
| 31 | Sat | 2022-03-12 | 18:30 | Zulte Waregem | 1.5 | 3–0 | 2.3 | Eupen | 6,506 | Elindus Arena | Bert Put | Match Report | |
| 31 | Sat | 2022-03-12 | 20:45 | Oostende | 2.1 | 1–3 | 2.3 | Club Brugge | 6,402 | Diaz Arena | Alexandre Boucaut | Match Report | |
| 31 | Sun | 2022-03-13 | 13:30 | Anderlecht | 3.7 | 2–1 | 1.3 | Antwerp | 19,000 | Lotto Park | Lawrence Visser | Match Report | |
| 31 | Sun | 2022-03-13 | 16:00 | Genk | 1.7 | 0–1 | 0.6 | Sint-Truiden | 19,436 | Luminus Arena | Christof Dierick | Match Report | |
| 31 | Sun | 2022-03-13 | 18:30 | Beerschot | 0.9 | 0–2 | 2.2 | Gent | Olympisch Stadion | Kevin Van Damme | Match Report | ||
| 31 | Sun | 2022-03-13 | 21:00 | Standard Liège | 0.5 | 0–1 | 2.3 | R.F.C. Seraing | 16,167 | Stade Maurice Dufrasne | Lothar D'Hondt | Match Report | |
| 32 | Fri | 2022-03-18 | 20:45 | Union SG | 1.8 | 1–1 | 0.3 | Oostende | 7,850 | Stade Joseph Mariën | Lothar D'Hondt | Match Report | |
| 32 | Sat | 2022-03-19 | 16:15 | Eupen | 1.1 | 1–1 | 2.6 | Mechelen | 2,487 | Stadion am Kehrweg | Jasper Vergoote | Match Report | |
| 32 | Sat | 2022-03-19 | 18:30 | R.F.C. Seraing | 0.8 | 1–1 | 0.9 | OH Leuven | 2,000 | Stade du Pairay | Bert Put | Match Report | |
| 32 | Sat | 2022-03-19 | 18:30 | Charleroi | 1.8 | 5–0 | 0.9 | Cercle Brugge | 5,636 | Stade du Pays de Charleroi | Bram Van Driessche | Match Report | |
| 32 | Sat | 2022-03-19 | 20:45 | Antwerp | 2.4 | 1–0 | 0.3 | Zulte Waregem | 12,330 | Bosuilstadion | Alexandre Boucaut | Match Report | |
| 32 | Sun | 2022-03-20 | 13:30 | Club Brugge | 1.5 | 3–1 | 0.7 | Genk | 21,496 | Jan Breydelstadion | Nicolas Laforge | Match Report | |
| 32 | Sun | 2022-03-20 | 16:00 | Kortrijk | 0.8 | 0–1 | 0.8 | Standard Liège | 6,576 | Guldensporenstadion | Kevin Van Damme | Match Report | |
| 32 | Sun | 2022-03-20 | 18:30 | Gent | 0.4 | 1–0 | 1.3 | Anderlecht | 19,990 | GHELAMCO-arena | Jonathan Lardot | Match Report | |
| 32 | Sun | 2022-03-20 | 21:00 | Sint-Truiden | 3.2 | 3–2 | 1.7 | Beerschot | 2,000 | Stayen | Wesli De Cremer | Match Report | |
| 33 | Fri | 2022-04-01 | 20:45 | Beerschot | 1.0 | 1–3 | 4.0 | Club Brugge | Olympisch Stadion | Brent Staessens | Match Report | ||
| 33 | Sat | 2022-04-02 | 16:15 | Zulte Waregem | 1.3 | 0–2 | 1.5 | Sint-Truiden | 8,763 | Elindus Arena | Lawrence Visser | Match Report | |
| 33 | Sat | 2022-04-02 | 18:30 | Oostende | 2.0 | 2–2 | 1.6 | R.F.C. Seraing | 4,086 | Diaz Arena | Jan Boterberg | Match Report | |
| 33 | Sat | 2022-04-02 | 18:30 | Mechelen | 1.5 | 3–2 | 2.3 | Kortrijk | 9,679 | AFAS-stadion Achter de Kazerne | Christof Dierick | Match Report | |
| 33 | Sat | 2022-04-02 | 20:45 | OH Leuven | 1.6 | 0–1 | 1.2 | Antwerp | 6,491 | King Power at Den Dreef Stadion | Jonathan Lardot | Match Report | |
| 33 | Sun | 2022-04-03 | 13:30 | Standard Liège | 0.3 | 1–3 | 1.2 | Union SG | 21,367 | Stade Maurice Dufrasne | Nathan Verboomen | Match Report | |
| 33 | Sun | 2022-04-03 | 16:00 | Cercle Brugge | 2.1 | 2–2 | 1.4 | Gent | 6,572 | Jan Breydelstadion | Nicolas Laforge | Match Report | |
| 33 | Sun | 2022-04-03 | 18:30 | Anderlecht | 3.8 | 4–0 | 0.1 | Charleroi | 19,000 | Lotto Park | Erik Lambrechts | Match Report | |
| 33 | Sun | 2022-04-03 | 21:00 | Genk | 3.8 | 5–0 | 0.3 | Eupen | 10,318 | Luminus Arena | Alexandre Boucaut | Match Report | |
| 34 | Sat | 2022-04-09 | 18:30 | Eupen | 0.9 | 0–2 | 1.0 | Oostende | 2,000 | Stadion am Kehrweg | Brent Staessens | Match Report | |
| 34 | Sat | 2022-04-09 | 20:45 | Antwerp | 1.6 | 1–1 | 0.7 | Cercle Brugge | 12,336 | Bosuilstadion | Kevin Van Damme | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Sint-Truiden | 3.2 | 3–0 | 0.9 | Standard Liège | 10,076 | Stayen | Lothar D'Hondt | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Club Brugge | 2.6 | 2–0 | 0.5 | Mechelen | 21,802 | Jan Breydelstadion | Bram Van Driessche | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | R.F.C. Seraing | 0.2 | 0–2 | 1.4 | Genk | 2,500 | Stade du Pairay | Arthur Denil | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Charleroi | 1.8 | 3–0 | 1.0 | Zulte Waregem | 7,866 | Stade du Pays de Charleroi | Wesli De Cremer | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Kortrijk | 1.9 | 2–3 | 1.4 | Anderlecht | 8,950 | Guldensporenstadion | Jan Boterberg | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Gent | 2.8 | 5–0 | 0.3 | OH Leuven | 19,524 | GHELAMCO-arena | Jasper Vergoote | Match Report | |
| 34 | Sun | 2022-04-10 | 18:30 | Union SG | 5–0 | Beerschot | 6,763 | Stade Joseph Mariën | Alexandre Boucaut | Match Report | Match awarded to Union SG |
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Play-off II | 1 | Sat | 2022-04-23 | 20:45 | Mechelen | 0.4 | 1–0 | 1.8 | Charleroi | 9,068 | AFAS-stadion Achter de Kazerne | Nicolas Laforge | Match Report | |
| Play-off I | 1 | Sun | 2022-04-24 | 13:30 | Club Brugge | 0.7 | 1–0 | 0.6 | Antwerp | 24,616 | Jan Breydelstadion | Erik Lambrechts | Match Report | |
| Play-off II | 1 | Sun | 2022-04-24 | 16:00 | Gent | 0.3 | 0–1 | 2.8 | Genk | 18,474 | GHELAMCO-arena | Nathan Verboomen | Match Report | |
| Play-off I | 1 | Sun | 2022-04-24 | 18:30 | Union SG | 2.7 | 3–1 | 1.9 | Anderlecht | 8,700 | Stade Joseph Mariën | Jonathan Lardot | Match Report | |
| Play-off II | 2 | Fri | 2022-04-29 | 20:45 | Genk | 1.8 | 4–2 | 1.8 | Mechelen | 14,021 | Luminus Arena | Lawrence Visser | Match Report | |
| Play-off II | 2 | Sat | 2022-04-30 | 18:30 | Charleroi | 1.7 | 1–3 | 2.2 | Gent | 4,985 | Stade du Pays de Charleroi | Erik Lambrechts | Match Report | |
| Play-off I | 2 | Sun | 2022-05-01 | 13:30 | Antwerp | 0.5 | 0–0 | 1.8 | Union SG | 11,781 | Bosuilstadion | Nicolas Laforge | Match Report | |
| Play-off I | 2 | Sun | 2022-05-01 | 18:30 | Anderlecht | 1.1 | 0–0 | 0.5 | Club Brugge | 19,000 | Lotto Park | Nathan Verboomen | Match Report | |
| Play-off II | 3 | Fri | 2022-05-06 | 20:45 | Charleroi | 1.3 | 2–2 | 1.4 | Genk | 4,614 | Stade du Pays de Charleroi | Lothar D'Hondt | Match Report | |
| Play-off II | 3 | Sat | 2022-05-07 | 20:45 | Gent | 0.6 | 1–0 | 1.0 | Mechelen | 8,363 | GHELAMCO-arena | Alexandre Boucaut | Match Report | |
| Play-off I | 3 | Sun | 2022-05-08 | 13:30 | Union SG | 1.9 | 0–2 | 1.6 | Club Brugge | 9,000 | Stade Joseph Mariën | Lawrence Visser | Match Report | |
| Play-off I | 3 | Sun | 2022-05-08 | 18:30 | Antwerp | 0.6 | 0–4 | 1.3 | Anderlecht | 13,800 | Bosuilstadion | Jonathan Lardot | Match Report | |
| Play-off II | 4 | Tue | 2022-05-10 | 18:45 | Mechelen | 2.6 | 1–2 | 1.8 | Gent | 8,213 | AFAS-stadion Achter de Kazerne | Jan Boterberg | Match Report | |
| Play-off II | 4 | Tue | 2022-05-10 | 21:00 | Genk | 4.1 | 3–2 | 1.1 | Charleroi | 10,000 | Luminus Arena | Jasper Vergoote | Match Report | |
| Play-off I | 4 | Wed | 2022-05-11 | 20:30 | Club Brugge | 2.1 | 1–0 | 1.3 | Union SG | 25,856 | Jan Breydelstadion | Erik Lambrechts | Match Report | |
| Play-off I | 4 | Thu | 2022-05-12 | 20:30 | Anderlecht | 1.8 | 2–1 | 0.6 | Antwerp | 19,000 | Lotto Park | Nicolas Laforge | Match Report | |
| Play-off II | 5 | Sat | 2022-05-14 | 20:45 | Charleroi | 2.3 | 3–2 | 2.5 | Mechelen | 4,111 | Stade du Pays de Charleroi | Wim Smet | Match Report | |
| Play-off I | 5 | Sun | 2022-05-15 | 13:30 | Antwerp | 1.4 | 1–3 | 1.3 | Club Brugge | 15,126 | Bosuilstadion | Lawrence Visser | Match Report | |
| Play-off II | 5 | Sun | 2022-05-15 | 16:00 | Genk | 1.3 | 0–2 | 1.4 | Gent | 12,000 | Luminus Arena | Nicolas Laforge | Match Report | |
| Play-off I | 5 | Sun | 2022-05-15 | 18:30 | Anderlecht | 0.7 | 0–2 | 1.8 | Union SG | 19,000 | Lotto Park | Bram Van Driessche | Match Report | |
| Play-off II | 6 | Sat | 2022-05-21 | 20:45 | Gent | 3.3 | 1–2 | 1.5 | Charleroi | 8,747 | GHELAMCO-arena | Wesli De Cremer | Match Report | |
| Play-off II | 6 | Sat | 2022-05-21 | 20:45 | Mechelen | 1.3 | 0–0 | 2.5 | Genk | 11,278 | AFAS-stadion Achter de Kazerne | Christof Dierick | Match Report | |
| Play-off I | 6 | Sun | 2022-05-22 | 16:00 | Union SG | 1.6 | 0–1 | 1.2 | Antwerp | 8,500 | Stade Joseph Mariën | Jasper Vergoote | Match Report | |
| Play-off I | 6 | Sun | 2022-05-22 | 18:30 | Club Brugge | 1.6 | 1–1 | 1.7 | Anderlecht | 26,000 | Jan Breydelstadion | Lothar D'Hondt | Match Report |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-04-23 | 18:30 | RWD Molenbeek | 0–1 | R.F.C. Seraing | 10,000 | Stade Edmond Machtens | Bram Van Driessche | Match Report | Leg 1 of 2 | ||
| Sat | 2022-04-30 | 20:45 | R.F.C. Seraing | 0–0 | RWD Molenbeek | Stade du Pairay | Jonathan Lardot | Match Report | Leg 2 of 2; R.F.C. Seraing won |
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