Scores & Fixtures 2022 Major League Soccer
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-02-26 | 12:30 | LAFC | 2.4 | 3–0 | 0.4 | Colorado Rapids | 22,010 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-02-26 | 13:00 | Philadelphia Union | 1.1 | 1–1 | 1.1 | Minnesota Utd | 17,487 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-02-26 | 15:00 | SJ Earthquakes | 1.1 | 1–3 | 3.0 | NY Red Bulls | 16,146 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-02-26 | 15:30 | Columbus Crew | 3.4 | 4–0 | 0.5 | Vancouver W'caps | 18,939 | Lower.com Field | Nima Saghafi | Match Report | |
| Sat | 2022-02-26 | 16:30 | FC Dallas | 1.9 | 1–1 | 1.5 | Toronto FC | 12,233 | Toyota Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-02-26 | 17:00 | Austin | 2.3 | 5–0 | 1.7 | FC Cincinnati | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-02-26 | 18:00 | D.C. United | 1.6 | 3–0 | 1.2 | Charlotte | 16,412 | Audi Field | Victor Rivas | Match Report | |
| Sat | 2022-02-26 | 18:00 | Inter Miami | 1.6 | 0–0 | 1.1 | Chicago Fire | 15,973 | DRV PNK Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-02-27 | 13:00 | Orlando City | 1.4 | 2–0 | 0.6 | CF Montréal | 21,283 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-02-27 | 14:00 | LA Galaxy | 1.6 | 1–0 | 1.0 | NYCFC | 25,174 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sun | 2022-02-27 | 15:00 | Atlanta Utd | 1.5 | 3–1 | 1.2 | Sporting KC | 67,523 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Sat | 2022-02-26 | 16:30 | Portland Timbers | 2.7 | 2–2 | 1.2 | NE Revolution | 23,411 | Providence Park | Chris Penso | Match Report | |
| Sun | 2022-02-27 | 17:00 | Seattle Sounders FC | 0.5 | 0–1 | 1.0 | Nashville SC | 30,013 | Lumen Field | Alex Chilowicz | Match Report | |
| Sun | 2022-02-27 | 18:00 | Houston Dynamo | 0.5 | 0–0 | 0.4 | Real Salt Lake | 18,561 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-05 | 13:30 | NE Revolution | 1.7 | 1–0 | 1.0 | FC Dallas | 14,554 | Gillette Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-05 | 14:00 | Toronto FC | 0.7 | 1–4 | 2.3 | NY Red Bulls | 23,121 | BMO Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-05 | 14:30 | Sporting KC | 1.5 | 1–0 | 0.2 | Houston Dynamo | 18,872 | Children's Mercy Park | Victor Rivas | Match Report | |
| Sat | 2022-03-05 | 14:30 | SJ Earthquakes | 1.3 | 3–3 | 1.9 | Columbus Crew | 12,888 | PayPal Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-05 | 15:00 | Vancouver W'caps | 0.5 | 0–0 | 1.9 | NYCFC | 18,643 | BC Place Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-03-05 | 16:00 | CF Montréal | 0.7 | 1–2 | 1.1 | Philadelphia Union | 13,067 | Stade Olympique | Drew Fischer | Match Report | |
| Sat | 2022-03-05 | 16:00 | Colorado Rapids | 1.6 | 3–0 | 1.1 | Atlanta Utd | 12,538 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Sat | 2022-03-05 | 16:00 | Real Salt Lake | 2.3 | 1–0 | 0.8 | Seattle Sounders FC | 20,017 | Rio Tinto Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-05 | 17:00 | Minnesota Utd | 1.8 | 1–1 | 1.6 | Nashville SC | 18,107 | Allianz Field | Armando Villarreal | Match Report | |
| Sat | 2022-03-05 | 17:00 | Chicago Fire | 0.5 | 0–0 | 0.2 | Orlando City | 25,477 | Soldier Field | Ismir Pekmic | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-03-05 | 18:00 | FC Cincinnati | 2.4 | 0–1 | 1.7 | D.C. United | 22,183 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-06 | 15:00 | Austin | 1.9 | 5–1 | 0.7 | Inter Miami | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-05 | 19:30 | Charlotte | 0.5 | 0–1 | 2.1 | LA Galaxy | 74,479 | Bank of America Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-03-06 | 19:00 | LAFC | 2.2 | 1–1 | 0.6 | Portland Timbers | 22,102 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 12:30 | Seattle Sounders FC | 2.1 | 3–2 | 2.2 | LA Galaxy | 33,200 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-03-12 | 13:00 | NYCFC | 1.9 | 4–1 | 2.4 | CF Montréal | 21,113 | Yankee Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-03-12 | 13:30 | Columbus Crew | 1.5 | 2–1 | 0.9 | Toronto FC | 16,116 | Lower.com Field | Ismail Elfath | Match Report | |
| Sat | 2022-03-12 | 13:30 | Inter Miami | 0.4 | 0–2 | 0.5 | LAFC | 11,465 | DRV PNK Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-12 | 17:30 | Houston Dynamo | 2.2 | 2–1 | 1.5 | Vancouver W'caps | 13,028 | PNC Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-03-13 | 16:30 | Atlanta Utd | 2.0 | 2–1 | 1.0 | Charlotte | 43,055 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-12 | 19:00 | Portland Timbers | 1.3 | 1–0 | 1.1 | Austin | 22,795 | Providence Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-13 | 19:00 | NY Red Bulls | 2.3 | 0–1 | 0.7 | Minnesota Utd | 14,848 | Red Bull Arena | Lukasz Szpala | Match Report | |
| Sat | 2022-03-12 | 19:00 | Colorado Rapids | 2.4 | 2–0 | 0.8 | Sporting KC | 12,387 | Dick's Sporting Goods Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-12 | 19:30 | Orlando City | 1.4 | 1–2 | 1.2 | FC Cincinnati | 16,512 | Exploria Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-12 | 19:30 | NE Revolution | 1.2 | 2–3 | 2.2 | Real Salt Lake | 10,633 | Gillette Stadium | Drew Fischer | Match Report | |
| Sat | 2022-03-12 | 19:30 | FC Dallas | 1.7 | 2–0 | 0.2 | Nashville SC | 13,448 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-03-12 | 19:30 | Philadelphia Union | 2.7 | 2–0 | 0.3 | SJ Earthquakes | 14,533 | Subaru Park | Victor Rivas | Match Report | |
| Sat | 2022-03-12 | 19:30 | D.C. United | 1.3 | 0–2 | 1.7 | Chicago Fire | 13,795 | Audi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-03-19 | 12:30 | LA Galaxy | 2.3 | 0–1 | 0.5 | Orlando City | 25,174 | Dignity Health Sports Park | Alex Chilowicz | Match Report | |
| Sat | 2022-03-19 | 13:00 | NYCFC | 1.4 | 0–2 | 2.1 | Philadelphia Union | 15,968 | Yankee Stadium | Ted Unkel | Match Report | |
| Sat | 2022-03-19 | 13:00 | FC Cincinnati | 2.5 | 3–1 | 1.4 | Inter Miami | 19,365 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-03-19 | 15:00 | Toronto FC | 1.4 | 2–1 | 1.1 | D.C. United | 21,501 | BMO Field | Ramy Touchan | Match Report | |
| Sat | 2022-03-19 | 16:00 | Atlanta Utd | 0.7 | 3–3 | 2.9 | CF Montréal | 42,578 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sat | 2022-03-19 | 17:00 | Chicago Fire | 1.7 | 3–1 | 0.5 | Sporting KC | 9,352 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-03-19 | 19:00 | Charlotte | 1.3 | 3–1 | 1.8 | NE Revolution | 29,318 | Bank of America Stadium | Marcos de Oliveira | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-03-20 | 14:00 | NY Red Bulls | 1.4 | 1–1 | 2.7 | Columbus Crew | 15,323 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-03-20 | 15:30 | Austin | 2.0 | 1–1 | 1.7 | Seattle Sounders FC | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-03-19 | 19:00 | Minnesota Utd | 1.8 | 1–0 | 0.3 | SJ Earthquakes | 18,685 | Allianz Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-03-19 | 19:30 | Houston Dynamo | 1.1 | 1–1 | 1.2 | Colorado Rapids | 17,007 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-03-19 | 19:30 | FC Dallas | 1.6 | 4–1 | 0.8 | Portland Timbers | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-03-19 | 19:30 | Real Salt Lake | 0.9 | 2–1 | 2.3 | Nashville SC | 20,036 | Rio Tinto Stadium | Tori Penso | Match Report | |
| Sun | 2022-03-20 | 19:00 | LAFC | 1.7 | 3–1 | 1.1 | Vancouver W'caps | 22,065 | Banc of California Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-03-26 | 17:00 | Charlotte | 1.0 | 2–0 | 1.6 | FC Cincinnati | 30,242 | Bank of America Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-03-26 | 18:00 | Sporting KC | 1.0 | 1–0 | 1.0 | Real Salt Lake | 19,107 | Children's Mercy Park | Joe Dickerson | Match Report | |
| Sun | 2022-03-27 | 13:00 | Portland Timbers | 1.9 | 1–1 | 0.8 | Orlando City | 22,948 | Providence Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-04-02 | 14:30 | Chicago Fire | 0.7 | 0–0 | 0.3 | FC Dallas | 11,411 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-02 | 16:00 | Toronto FC | 0.9 | 2–1 | 1.1 | NYCFC | 21,802 | BMO Field | Drew Fischer | Match Report | |
| Sat | 2022-04-02 | 16:00 | FC Cincinnati | 2.6 | 3–4 | 1.7 | CF Montréal | 20,386 | TQL Stadium | Tori Penso | Match Report | |
| Sat | 2022-04-02 | 16:30 | SJ Earthquakes | 2.9 | 2–2 | 2.3 | Austin | 13,062 | PayPal Park | Alex Chilowicz | Match Report | |
| Sat | 2022-04-02 | 18:00 | Columbus Crew | 1.7 | 0–1 | 0.9 | Nashville SC | 20,371 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-02 | 19:30 | NE Revolution | 1.1 | 0–1 | 0.8 | NY Red Bulls | 16,265 | Gillette Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-02 | 19:30 | Philadelphia Union | 1.0 | 2–0 | 0.6 | Charlotte | 18,136 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-04-02 | 19:30 | Orlando City | 1.4 | 2–4 | 2.7 | LAFC | 16,753 | Exploria Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-04-02 | 19:30 | D.C. United | 0.5 | 0–1 | 1.0 | Atlanta Utd | 17,289 | Audi Field | Armando Villarreal | Match Report | |
| Sun | 2022-04-03 | 13:30 | Portland Timbers | 1.1 | 1–3 | 1.5 | LA Galaxy | 24,534 | Providence Park | Nima Saghafi | Match Report | |
| Sat | 2022-04-02 | 17:00 | Vancouver W'caps | 1.0 | 1–0 | 0.6 | Sporting KC | 16,772 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-04-02 | 19:00 | Minnesota Utd | 2.1 | 1–2 | 1.5 | Seattle Sounders FC | 19,615 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-04-02 | 19:00 | Colorado Rapids | 1.7 | 1–1 | 1.1 | Real Salt Lake | 13,380 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-04-02 | 20:00 | Inter Miami | 1.8 | 1–3 | 2.5 | Houston Dynamo | 13,083 | DRV PNK Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 13:00 | Orlando City | 3.4 | 1–0 | 0.5 | Chicago Fire | 16,051 | Exploria Stadium | Victor Rivas | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-09 | 15:00 | Inter Miami | 1.3 | 3–2 | 1.2 | NE Revolution | 11,472 | DRV PNK Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-09 | 16:00 | NY Red Bulls | 1.4 | 1–2 | 1.7 | CF Montréal | 15,734 | Red Bull Arena | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-04-09 | 16:30 | LA Galaxy | 1.0 | 2–1 | 2.0 | LAFC | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-04-09 | 18:00 | Philadelphia Union | 1.8 | 1–0 | 1.4 | Columbus Crew | 18,321 | Subaru Park | Armando Villarreal | Match Report | |
| Sun | 2022-04-10 | 13:30 | Charlotte | 0.9 | 1–0 | 1.3 | Atlanta Utd | 32,496 | Bank of America Stadium | Allen Chapman | Match Report | |
| Sat | 2022-04-09 | 18:00 | Real Salt Lake | 1.3 | 2–2 | 0.9 | Toronto FC | 20,136 | Rio Tinto Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-10 | 18:30 | Austin | 1.2 | 1–0 | 0.5 | Minnesota Utd | 20,738 | Q2 Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-09 | 19:00 | Vancouver W'caps | 2.5 | 2–3 | 1.3 | Portland Timbers | 16,772 | BC Place Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-04-09 | 19:30 | Houston Dynamo | 1.4 | 4–3 | 1.4 | SJ Earthquakes | 15,414 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-04-09 | 19:30 | Sporting KC | 1.2 | 1–2 | 2.8 | Nashville SC | 18,852 | Children's Mercy Park | Ismail Elfath | Match Report | |
| Sat | 2022-04-09 | 19:30 | FC Dallas | 1.4 | 3–1 | 2.1 | Colorado Rapids | 15,893 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-04-16 | 12:30 | SJ Earthquakes | 1.3 | 2–2 | 1.8 | Nashville SC | 10,394 | PayPal Park | Tim Ford | Match Report | |
| Sat | 2022-04-16 | 15:00 | CF Montréal | 1.5 | 2–1 | 0.3 | Vancouver W'caps | 12,042 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-04-16 | 17:00 | Houston Dynamo | 1.5 | 0–0 | 1.5 | Portland Timbers | 13,650 | PNC Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-16 | 18:00 | Atlanta Utd | 2.8 | 0–0 | 1.3 | FC Cincinnati | 42,948 | Mercedes-Benz Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-16 | 19:00 | NY Red Bulls | 1.6 | 0–0 | 0.5 | FC Dallas | 14,456 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Sat | 2022-04-16 | 19:30 | D.C. United | 1.5 | 2–3 | 2.8 | Austin | 16,840 | Audi Field | Tori Penso | Match Report | |
| Sat | 2022-04-16 | 19:30 | Toronto FC | 0.4 | 2–1 | 1.7 | Philadelphia Union | 20,809 | BMO Field | Alex Chilowicz | Match Report | |
| Sat | 2022-04-16 | 19:30 | Columbus Crew | 1.3 | 0–2 | 1.3 | Orlando City | 18,030 | Lower.com Field | Drew Fischer | Match Report | |
| Sat | 2022-04-16 | 19:30 | NE Revolution | 1.3 | 2–1 | 0.5 | Charlotte | 15,344 | Gillette Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-04-17 | 13:00 | LAFC | 2.0 | 3–1 | 1.0 | Sporting KC | 22,097 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-04-17 | 13:00 | NYCFC | 3.3 | 6–0 | 1.2 | Real Salt Lake | 14,513 | Yankee Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-16 | 19:00 | Seattle Sounders FC | 1.1 | 0–1 | 0.7 | Inter Miami | 32,126 | Lumen Field | Joe Dickerson | Match Report | |
| Sat | 2022-04-16 | 19:00 | Minnesota Utd | 1.9 | 3–1 | 2.0 | Colorado Rapids | 19,629 | Allianz Field | Chris Penso | Match Report | |
| Sat | 2022-04-16 | 19:00 | Chicago Fire | 0.4 | 0–0 | 0.4 | LA Galaxy | 30,282 | Soldier Field | Ted Unkel | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-23 | 14:00 | FC Dallas | 2.2 | 2–1 | 1.0 | Houston Dynamo | 15,792 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-04-23 | 15:00 | Philadelphia Union | 1.2 | 1–1 | 0.5 | CF Montréal | 18,476 | Subaru Park | Lukasz Szpala | Match Report | |
| Sat | 2022-04-23 | 16:00 | Minnesota Utd | 0.9 | 3–0 | 1.0 | Chicago Fire | 19,658 | Allianz Field | Silviu Petrescu | Match Report | |
| Sat | 2022-04-23 | 19:30 | D.C. United | 1.5 | 3–2 | 2.0 | NE Revolution | 17,131 | Audi Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-04-24 | 13:00 | Inter Miami | 1.9 | 2–1 | 2.1 | Atlanta Utd | 13,433 | DRV PNK Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-04-24 | 15:30 | Orlando City | 0.1 | 0–3 | 2.3 | NY Red Bulls | 17,503 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-04-24 | 17:00 | FC Cincinnati | 1.5 | 1–2 | 1.8 | LAFC | 20,883 | TQL Stadium | Ismail Elfath | Match Report | |
| Sun | 2022-04-24 | 17:00 | NYCFC | 4.2 | 5–4 | 1.2 | Toronto FC | 17,626 | Citi Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-04-23 | 19:00 | Colorado Rapids | 0.6 | 0–0 | 1.2 | Charlotte | 13,160 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-04-23 | 19:00 | SJ Earthquakes | 2.7 | 4–3 | 2.5 | Seattle Sounders FC | 12,467 | PayPal Park | Ted Unkel | Match Report | |
| Sat | 2022-04-23 | 19:00 | Portland Timbers | 0.5 | 0–0 | 0.9 | Real Salt Lake | 24,206 | Providence Park | Chris Penso | Match Report | |
| Sat | 2022-04-23 | 19:30 | Austin | 0.9 | 3–0 | 0.7 | Vancouver W'caps | 20,738 | Q2 Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-04-23 | 19:30 | LA Galaxy | 0.9 | 1–0 | 0.4 | Nashville SC | 26,674 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Sat | 2022-04-23 | 19:30 | Sporting KC | 0.3 | 0–0 | 0.7 | Columbus Crew | 18,483 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-04-30 | 12:30 | Houston Dynamo | 1.8 | 1–2 | 0.7 | Austin | 16,296 | PNC Stadium | Ted Unkel | Match Report | |
| Sat | 2022-04-30 | 13:30 | Real Salt Lake | 0.6 | 1–0 | 1.0 | LA Galaxy | 20,775 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Sat | 2022-04-30 | 15:00 | Toronto FC | 1.0 | 1–2 | 0.8 | FC Cincinnati | 23,591 | BMO Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-04-30 | 16:00 | CF Montréal | 1.9 | 2–1 | 0.8 | Atlanta Utd | 15,060 | Stade Saputo | Alex Chilowicz | Match Report | |
| Sat | 2022-04-30 | 19:30 | NE Revolution | 1.8 | 2–0 | 0.5 | Inter Miami | 25,509 | Gillette Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-04-30 | 19:30 | Columbus Crew | 1.5 | 3–0 | 1.4 | D.C. United | 19,402 | Lower.com Field | Tim Ford | Match Report | |
| Sat | 2022-04-30 | 19:30 | Orlando City | 1.5 | 2–1 | 1.2 | Charlotte | 17,012 | Exploria Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-01 | 13:00 | NYCFC | 3.3 | 3–0 | 0.4 | SJ Earthquakes | 17,174 | Yankee Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-05-01 | 15:00 | Nashville SC | 2.0 | 1–1 | 1.1 | Philadelphia Union | 30,109 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-04-30 | 19:00 | Chicago Fire | 1.3 | 1–2 | 2.0 | NY Red Bulls | 11,108 | Soldier Field | Jon Freemon | Match Report | |
| Sat | 2022-04-30 | 19:00 | Colorado Rapids | 1.6 | 2–0 | 1.0 | Portland Timbers | 14,038 | Dick's Sporting Goods Park | Armando Villarreal | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-04-30 | 19:30 | Sporting KC | 1.8 | 2–2 | 1.0 | FC Dallas | 17,334 | Children's Mercy Park | Nima Saghafi | Match Report | |
| Sun | 2022-05-01 | 19:00 | LAFC | 2.3 | 2–0 | 0.7 | Minnesota Utd | 22,010 | Banc of California Stadium | Allen Chapman | Match Report | |
| Wed | 2022-05-04 | 19:30 | FC Cincinnati | 4.4 | 2–0 | 0.5 | Toronto FC | 19,563 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-07 | 15:30 | Charlotte | 1.7 | 1–0 | 1.2 | Inter Miami | 32,018 | Bank of America Stadium | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-07 | 16:00 | CF Montréal | 3.3 | 4–1 | 0.2 | Orlando City | 14,068 | Stade Saputo | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-07 | 18:00 | Atlanta Utd | 2.5 | 4–1 | 1.8 | Chicago Fire | 42,547 | Mercedes-Benz Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-07 | 19:00 | NYCFC | 1.4 | 0–0 | 0.3 | Sporting KC | 15,031 | Citi Field | Tim Ford | Match Report | |
| Sat | 2022-05-07 | 19:00 | NY Red Bulls | 1.2 | 1–1 | 0.5 | Portland Timbers | 17,107 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sat | 2022-05-07 | 19:30 | D.C. United | 0.9 | 2–0 | 0.7 | Houston Dynamo | 15,194 | Audi Field | Jon Freemon | Match Report | |
| Sat | 2022-05-07 | 19:30 | NE Revolution | 1.0 | 2–2 | 1.1 | Columbus Crew | 26,421 | Gillette Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-08 | 13:00 | Vancouver W'caps | 2.3 | 1–0 | 1.8 | Toronto FC | 17,709 | BC Place Stadium | Victor Rivas | Match Report | |
| Sun | 2022-05-08 | 16:00 | Nashville SC | 2.4 | 2–0 | 0.3 | Real Salt Lake | 28,226 | Geodis Park | Fotis Bazakos | Match Report | |
| Sun | 2022-05-08 | 18:00 | Austin | 1.2 | 0–1 | 1.3 | LA Galaxy | 20,738 | Q2 Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-07 | 19:00 | Minnesota Utd | 1.0 | 0–1 | 2.0 | FC Cincinnati | 19,662 | Allianz Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-07 | 19:00 | SJ Earthquakes | 1.1 | 1–0 | 0.8 | Colorado Rapids | 14,077 | PayPal Park | Tori Penso | Match Report | |
| Sat | 2022-05-07 | 19:30 | FC Dallas | 2.6 | 2–0 | 0.7 | Seattle Sounders FC | 19,096 | Toyota Stadium | Allen Chapman | Match Report | |
| Sat | 2022-05-07 | 20:00 | LAFC | 1.4 | 2–2 | 1.1 | Philadelphia Union | 22,022 | Banc of California Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-05-14 | 15:00 | Toronto FC | 0.7 | 0–1 | 1.5 | Orlando City | 26,146 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-05-14 | 15:30 | Colorado Rapids | 3.1 | 2–0 | 1.3 | LAFC | 15,022 | Dick's Sporting Goods Park | Ted Unkel | Match Report | |
| Sat | 2022-05-14 | 16:00 | Vancouver W'caps | 1.3 | 3–3 | 1.7 | SJ Earthquakes | 15,087 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-05-14 | 19:00 | NYCFC | 2.6 | 2–0 | 0.5 | Columbus Crew | 18,813 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sat | 2022-05-14 | 19:00 | Charlotte | 1.3 | 0–2 | 1.8 | CF Montréal | 33,323 | Bank of America Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-14 | 19:30 | Philadelphia Union | 2.5 | 1–1 | 1.1 | NY Red Bulls | 18,579 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-05-15 | 13:00 | Seattle Sounders FC | 2.8 | 3–1 | 1.5 | Minnesota Utd | 32,613 | Lumen Field | Joe Dickerson | Match Report | |
| Sun | 2022-05-15 | 13:30 | Atlanta Utd | 2.2 | 2–2 | 1.3 | NE Revolution | 42,516 | Mercedes-Benz Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-05-14 | 19:00 | Chicago Fire | 1.5 | 1–2 | 0.9 | FC Cincinnati | 14,049 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-05-14 | 19:00 | Portland Timbers | 3.1 | 7–2 | 1.7 | Sporting KC | 23,503 | Providence Park | Victor Rivas | Match Report | |
| Sat | 2022-05-14 | 19:30 | LA Galaxy | 1.6 | 1–3 | 3.1 | FC Dallas | 25,174 | Dignity Health Sports Park | Chris Penso | Match Report | |
| Sat | 2022-05-14 | 19:30 | Real Salt Lake | 1.8 | 2–1 | 0.9 | Austin | 20,122 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-05-14 | 19:30 | Houston Dynamo | 1.7 | 2–0 | 1.4 | Nashville SC | 16,035 | PNC Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-05-14 | 20:00 | Inter Miami | 0.8 | 2–2 | 1.1 | D.C. United | 13,317 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-05-18 | 19:30 | Philadelphia Union | 1.6 | 0–0 | 0.9 | Inter Miami | 15,747 | Subaru Park | Fotis Bazakos | Match Report | |
| Wed | 2022-05-18 | 19:30 | NY Red Bulls | 2.2 | 3–3 | 1.7 | Chicago Fire | 13,257 | Red Bull Arena | Ted Unkel | Match Report | |
| Wed | 2022-05-18 | 19:30 | D.C. United | 0.6 | 0–2 | 1.5 | NYCFC | 16,072 | Audi Field | Chris Penso | Match Report | |
| Wed | 2022-05-18 | 19:00 | Minnesota Utd | 2.7 | 1–1 | 2.4 | LA Galaxy | 19,645 | Allianz Field | Jair Marrufo | Match Report | |
| Wed | 2022-05-18 | 19:00 | Vancouver W'caps | 1.2 | 2–1 | 1.0 | FC Dallas | 12,716 | BC Place Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-05-18 | 19:30 | SJ Earthquakes | 2.0 | 3–2 | 1.1 | Portland Timbers | 11,788 | PayPal Park | Lukasz Szpala | Match Report | |
| Wed | 2022-05-18 | 19:30 | Nashville SC | 0.6 | 2–1 | 0.8 | CF Montréal | 26,003 | Geodis Park | Jon Freemon | Match Report | |
| Wed | 2022-05-18 | 19:30 | Houston Dynamo | 1.2 | 0–1 | 1.3 | Seattle Sounders FC | 11,093 | PNC Stadium | Rubiel Vazquez | Match Report | |
| Wed | 2022-05-18 | 19:30 | Sporting KC | 0.5 | 2–1 | 1.3 | Colorado Rapids | 17,233 | Children's Mercy Park | Drew Fischer | Match Report | |
| Wed | 2022-05-18 | 19:30 | LAFC | 1.9 | 1–2 | 0.7 | Austin | 22,034 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-21 | 15:30 | Columbus Crew | 0.9 | 0–2 | 1.8 | LAFC | 19,649 | Lower.com Field | Victor Rivas | Match Report | |
| Sat | 2022-05-21 | 18:00 | FC Cincinnati | 0.9 | 2–3 | 0.8 | NE Revolution | 22,844 | TQL Stadium | Silviu Petrescu | Match Report | |
| Sat | 2022-05-21 | 18:30 | Nashville SC | 1.5 | 2–2 | 1.9 | Atlanta Utd | 30,109 | Geodis Park | Ted Unkel | Match Report | |
| Sat | 2022-05-21 | 18:30 | D.C. United | 3.0 | 2–2 | 2.0 | Toronto FC | 18,320 | Audi Field | Ismir Pekmic | Match Report | |
| Sun | 2022-05-22 | 16:00 | CF Montréal | 0.6 | 1–2 | 2.0 | Real Salt Lake | 14,205 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-05-22 | 16:30 | SJ Earthquakes | 1.0 | 1–1 | 1.3 | Sporting KC | 14,233 | PayPal Park | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-05-22 | 17:00 | Charlotte | 1.9 | 2–1 | 1.0 | Vancouver W'caps | 32,034 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sun | 2022-05-22 | 17:00 | NYCFC | 2.0 | 1–0 | 1.3 | Chicago Fire | 18,823 | Yankee Stadium | Fotis Bazakos | Match Report | |
| Sun | 2022-05-22 | 18:00 | Inter Miami | 1.9 | 2–0 | 1.3 | NY Red Bulls | 11,007 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-05-22 | 18:00 | FC Dallas | 1.3 | 1–2 | 0.8 | Minnesota Utd | 15,280 | Toyota Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-05-22 | 17:00 | LA Galaxy | 1.3 | 0–3 | 1.5 | Houston Dynamo | 22,471 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-22 | 18:00 | Colorado Rapids | 1.7 | 1–0 | 0.7 | Seattle Sounders FC | 14,923 | Dick's Sporting Goods Park | Tim Ford | Match Report | |
| Sun | 2022-05-22 | 19:00 | Portland Timbers | 0.8 | 0–2 | 1.1 | Philadelphia Union | 22,288 | Providence Park | Allen Chapman | Match Report | |
| Sun | 2022-05-22 | 19:00 | Austin | 3.1 | 2–2 | 1.8 | Orlando City | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 15:00 | LAFC | 2.1 | 3–2 | 1.9 | SJ Earthquakes | 22,007 | Banc of California Stadium | Ismail Elfath | Match Report | |
| Sat | 2022-05-28 | 19:00 | NY Red Bulls | 1.0 | 4–1 | 0.7 | D.C. United | 13,678 | Red Bull Arena | Allen Chapman | Match Report | |
| Sat | 2022-05-28 | 19:00 | Atlanta Utd | 2.0 | 1–2 | 0.8 | Columbus Crew | 42,504 | Mercedes-Benz Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-05-28 | 19:00 | Toronto FC | 1.1 | 3–2 | 3.2 | Chicago Fire | 25,906 | BMO Field | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-05-28 | 19:30 | CF Montréal | 2.8 | 4–3 | 0.9 | FC Cincinnati | 14,225 | Stade Saputo | Fotis Bazakos | Match Report | |
| Sat | 2022-05-28 | 19:30 | NE Revolution | 2.9 | 1–1 | 0.7 | Philadelphia Union | 20,398 | Gillette Stadium | Jon Freemon | Match Report | |
| Sat | 2022-05-28 | 19:30 | Orlando City | 1.2 | 1–3 | 1.5 | FC Dallas | 17,380 | Exploria Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-05-29 | 15:00 | LA Galaxy | 3.6 | 4–1 | 0.9 | Austin | 20,433 | Dignity Health Sports Park | Rubiel Vazquez | Match Report | |
| Sat | 2022-05-28 | 19:00 | Minnesota Utd | 1.1 | 0–1 | 0.6 | NYCFC | 19,695 | Allianz Field | Michael Radchuk | Match Report | |
| Sat | 2022-05-28 | 19:00 | Colorado Rapids | 0.9 | 1–3 | 1.7 | Nashville SC | 15,465 | Dick's Sporting Goods Park | Nima Saghafi | Match Report | |
| Sat | 2022-05-28 | 19:30 | Real Salt Lake | 2.7 | 3–0 | 1.1 | Houston Dynamo | 20,489 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-05-28 | 20:00 | Sporting KC | 1.1 | 0–1 | 1.3 | Vancouver W'caps | 19,206 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-05-28 | 20:00 | Inter Miami | 1.8 | 2–1 | 1.3 | Portland Timbers | 11,161 | DRV PNK Stadium | Chris Penso | Match Report | |
| Sun | 2022-05-29 | 18:30 | Seattle Sounders FC | 1.4 | 2–1 | 1.0 | Charlotte | 32,763 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-04 | 16:00 | Vancouver W'caps | 1.4 | 2–1 | 0.8 | Real Salt Lake | 17,134 | BC Place Stadium | Jon Freemon | Match Report | |
| Sat | 2022-06-11 | 15:00 | Charlotte | 2.1 | 2–0 | 0.6 | NY Red Bulls | 32,064 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-06-12 | 14:00 | Sporting KC | 1.0 | 1–2 | 1.3 | NE Revolution | 18,703 | Children's Mercy Park | Chris Penso | Match Report | |
| Sat | 2022-06-11 | 19:00 | Nashville SC | 1.3 | 0–0 | 0.6 | SJ Earthquakes | 28,672 | Geodis Park | Allen Chapman | Match Report | |
| Tue | 2022-06-14 | 19:30 | Seattle Sounders FC | 2.5 | 4–0 | 0.9 | Vancouver W'caps | 31,165 | Lumen Field | Lukasz Szpala | Match Report | |
| Wed | 2022-06-15 | 19:30 | NE Revolution | 1.1 | 1–1 | 0.8 | Orlando City | 15,308 | Gillette Stadium | Ramy Touchan | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-18 | 12:00 | Seattle Sounders FC | 1.2 | 1–1 | 1.3 | LAFC | 34,642 | Lumen Field | Allen Chapman | Match Report | |
| Sat | 2022-06-18 | 14:00 | LA Galaxy | 1.5 | 1–1 | 0.9 | Portland Timbers | 21,414 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-06-18 | 19:00 | NY Red Bulls | 1.7 | 2–0 | 1.4 | Toronto FC | 19,142 | Red Bull Arena | Ramy Touchan | Match Report | |
| Sat | 2022-06-18 | 19:30 | Columbus Crew | 1.1 | 1–1 | 0.7 | Charlotte | 20,446 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-06-18 | 19:30 | Philadelphia Union | 1.3 | 1–1 | 1.0 | FC Cincinnati | 18,717 | Subaru Park | Tim Ford | Match Report | |
| Sat | 2022-06-18 | 19:30 | CF Montréal | 1.4 | 0–1 | 1.5 | Austin | 15,045 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-06-18 | 19:30 | Orlando City | 3.0 | 2–1 | 0.7 | Houston Dynamo | 16,333 | Exploria Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-06-19 | 15:00 | Atlanta Utd | 2.1 | 2–0 | 0.9 | Inter Miami | 42,539 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-06-19 | 17:00 | NYCFC | 1.3 | 1–1 | 0.3 | Colorado Rapids | 19,812 | Yankee Stadium | Marcos de Oliveira | Match Report | |
| Sun | 2022-06-19 | 17:00 | Nashville SC | 0.9 | 1–2 | 0.4 | Sporting KC | 29,269 | Geodis Park | Victor Rivas | Match Report | |
| Sun | 2022-06-19 | 17:00 | NE Revolution | 0.5 | 2–1 | 1.3 | Minnesota Utd | 21,289 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-18 | 19:00 | Chicago Fire | 1.3 | 1–0 | 0.9 | D.C. United | 17,650 | Soldier Field | Nima Saghafi | Match Report | |
| Sat | 2022-06-18 | 19:30 | Real Salt Lake | 2.6 | 2–0 | 0.6 | SJ Earthquakes | 20,517 | Rio Tinto Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-06-18 | 20:00 | FC Dallas | 1.0 | 0–2 | 0.5 | Vancouver W'caps | 19,096 | Toyota Stadium | Tori Penso | Match Report | |
| Fri | 2022-06-24 | 19:30 | FC Cincinnati | 1.2 | 1–0 | 0.3 | Orlando City | 24,263 | TQL Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-06-25 | 12:00 | Seattle Sounders FC | 2.6 | 3–0 | 0.6 | Sporting KC | 33,380 | Lumen Field | Alex Chilowicz | Match Report | |
| Sat | 2022-06-25 | 17:00 | D.C. United | 0.8 | 1–3 | 1.1 | Nashville SC | 19,325 | Audi Field | Lukasz Szpala | Match Report | |
| Sat | 2022-06-25 | 19:30 | CF Montréal | 0.8 | 2–1 | 1.2 | Charlotte | 13,520 | Stade Saputo | Nima Saghafi | Match Report | |
| Sat | 2022-06-25 | 19:30 | Toronto FC | 2.0 | 2–1 | 1.4 | Atlanta Utd | 25,527 | BMO Field | Jon Freemon | Match Report | |
| Sun | 2022-06-26 | 12:00 | LAFC | 1.7 | 2–0 | 0.6 | NY Red Bulls | Banc of California Stadium | Joe Dickerson | Match Report | ||
| Sun | 2022-06-26 | 18:00 | Philadelphia Union | 1.8 | 2–1 | 1.4 | NYCFC | 18,589 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-06-25 | 19:00 | Houston Dynamo | 1.6 | 2–0 | 2.0 | Chicago Fire | 13,081 | PNC Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-06-25 | 19:30 | Portland Timbers | 3.1 | 3–0 | 1.5 | Colorado Rapids | 23,448 | Providence Park | Rosendo Mendoza | Match Report | |
| Sat | 2022-06-25 | 20:00 | Inter Miami | 1.6 | 2–1 | 0.8 | Minnesota Utd | 12,147 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sat | 2022-06-25 | 20:00 | Austin | 1.6 | 2–2 | 2.0 | FC Dallas | 20,738 | Q2 Stadium | Allen Chapman | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-06-25 | 20:00 | Real Salt Lake | 0.7 | 0–0 | 0.5 | Columbus Crew | 20,311 | Rio Tinto Stadium | Mark Allatin | Match Report | |
| Sun | 2022-06-26 | 17:00 | Vancouver W'caps | 1.2 | 0–0 | 1.2 | NE Revolution | 15,084 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-06-29 | 19:30 | Toronto FC | 1.7 | 1–2 | 0.8 | Columbus Crew | 21,289 | BMO Field | Armando Villarreal | Match Report | |
| Wed | 2022-06-29 | 19:30 | FC Cincinnati | 2.2 | 4–4 | 2.7 | NYCFC | 21,258 | TQL Stadium | Ismir Pekmic | Match Report | |
| Thu | 2022-06-30 | 19:00 | Charlotte | 0.5 | 0–1 | 0.4 | Austin | 31,661 | Bank of America Stadium | Tim Ford | Match Report | |
| Wed | 2022-06-29 | 19:00 | Chicago Fire | 0.7 | 1–0 | 0.5 | Philadelphia Union | 10,384 | Soldier Field | Michael Radchuk | Match Report | |
| Wed | 2022-06-29 | 19:00 | Seattle Sounders FC | 0.9 | 1–2 | 1.4 | CF Montréal | 32,375 | Lumen Field | Joe Dickerson | Match Report | |
| Wed | 2022-06-29 | 19:30 | LAFC | 1.9 | 3–1 | 0.6 | FC Dallas | 22,014 | Banc of California Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-06-29 | 19:30 | Portland Timbers | 1.4 | 2–1 | 2.2 | Houston Dynamo | 22,932 | Providence Park | Lukasz Szpala | Match Report | |
| Wed | 2022-06-29 | 19:30 | LA Galaxy | 2.4 | 2–3 | 1.2 | Minnesota Utd | 18,337 | Dignity Health Sports Park | Ted Unkel | Match Report | |
| Thu | 2022-06-30 | 20:00 | NY Red Bulls | 1.8 | 2–1 | 1.3 | Atlanta Utd | 14,122 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-07-02 | 19:30 | Toronto FC | 1.2 | 0–2 | 1.9 | Seattle Sounders FC | 23,594 | BMO Field | Silviu Petrescu | Match Report | |
| Sun | 2022-07-03 | 17:00 | NYCFC | 2.2 | 2–2 | 1.5 | Atlanta Utd | 17,704 | Yankee Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-02 | 19:00 | Vancouver W'caps | 0.9 | 1–0 | 0.4 | LAFC | 18,292 | BC Place Stadium | Guido Gonzalez Jr. | Match Report | |
| Sun | 2022-07-03 | 19:30 | NE Revolution | 1.5 | 2–2 | 1.5 | FC Cincinnati | 20,193 | Gillette Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-03 | 19:30 | Columbus Crew | 1.3 | 0–0 | 0.3 | Philadelphia Union | 20,469 | Lower.com Field | Nima Saghafi | Match Report | |
| Sun | 2022-07-03 | 18:00 | SJ Earthquakes | 2.5 | 2–1 | 1.6 | Chicago Fire | 13,224 | PayPal Park | Victor Rivas | Match Report | |
| Sun | 2022-07-03 | 19:00 | Minnesota Utd | 2.7 | 3–2 | 1.5 | Real Salt Lake | Allianz Field | Ramy Touchan | Match Report | ||
| Sun | 2022-07-03 | 19:00 | Sporting KC | 0.6 | 0–1 | 0.6 | NY Red Bulls | 19,065 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Mon | 2022-07-04 | 19:00 | Orlando City | 2.4 | 3–5 | 1.4 | D.C. United | 16 | Exploria Stadium | Allen Chapman | Match Report | |
| Sun | 2022-07-03 | 19:30 | Houston Dynamo | 1.1 | 1–2 | 1.7 | Charlotte | 19,242 | PNC Stadium | Jair Marrufo | Match Report | |
| Sun | 2022-07-03 | 19:30 | Nashville SC | 1.2 | 2–2 | 1.9 | Portland Timbers | 28,387 | Geodis Park | Armando Villarreal | Match Report | |
| Mon | 2022-07-04 | 19:00 | Colorado Rapids | 1.8 | 2–3 | 1.8 | Austin | 18,084 | Dick's Sporting Goods Park | Joe Dickerson | Match Report | |
| Mon | 2022-07-04 | 19:30 | LA Galaxy | 3.2 | 4–0 | 0.9 | CF Montréal | 23,855 | Dignity Health Sports Park | Tim Ford | Match Report | |
| Mon | 2022-07-04 | 20:00 | FC Dallas | 1.1 | 1–1 | 2.6 | Inter Miami | 19,096 | Toyota Stadium | Alex Chilowicz | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Fri | 2022-07-08 | 19:30 | Philadelphia Union | 5.6 | 7–0 | 0.7 | D.C. United | 19,007 | Subaru Park | Ted Unkel | Match Report | |
| Sat | 2022-07-09 | 13:00 | NYCFC | 5.3 | 4–2 | 1.6 | NE Revolution | 17,991 | Yankee Stadium | Tim Ford | Match Report | |
| Sat | 2022-07-09 | 13:30 | Seattle Sounders FC | 1.4 | 0–3 | 2.8 | Portland Timbers | 47,722 | Lumen Field | Chris Penso | Match Report | |
| Sat | 2022-07-09 | 19:00 | Atlanta Utd | 1.2 | 0–3 | 2.4 | Austin | 67,516 | Mercedes-Benz Stadium | Jair Marrufo | Match Report | |
| Sat | 2022-07-09 | 19:00 | Charlotte | 2.1 | 4–1 | 2.4 | Nashville SC | 36,244 | Bank of America Stadium | Joe Dickerson | Match Report | |
| Fri | 2022-07-08 | 19:00 | LAFC | 1.5 | 3–2 | 1.7 | LA Galaxy | 22,231 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-09 | 19:30 | FC Cincinnati | 1.5 | 1–1 | 1.2 | NY Red Bulls | 24,476 | TQL Stadium | Rosendo Mendoza | Match Report | |
| Fri | 2022-07-08 | 19:30 | Vancouver W'caps | 0.7 | 1–3 | 0.9 | Minnesota Utd | 14,201 | BC Place Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-09 | 19:30 | CF Montréal | 1.9 | 1–2 | 0.5 | Sporting KC | 14,127 | Stade Saputo | Ismir Pekmic | Match Report | |
| Sat | 2022-07-09 | 19:30 | Toronto FC | 1.8 | 2–2 | 1.3 | SJ Earthquakes | 27,149 | BMO Field | Fotis Bazakos | Match Report | |
| Sat | 2022-07-09 | 19:00 | Chicago Fire | 2.1 | 2–3 | 1.7 | Columbus Crew | 15,157 | Soldier Field | Ramy Touchan | Match Report | |
| Sat | 2022-07-09 | 19:30 | Houston Dynamo | 2.5 | 2–2 | 1.4 | FC Dallas | 21,284 | PNC Stadium | Jon Freemon | Match Report | |
| Sat | 2022-07-09 | 20:00 | Real Salt Lake | 1.3 | 2–2 | 2.9 | Colorado Rapids | 20,242 | Rio Tinto Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-07-09 | 22:00 | Orlando City | 0.9 | 1–0 | 0.8 | Inter Miami | 20,052 | Exploria Stadium | Nima Saghafi | Match Report | |
| Wed | 2022-07-13 | 19:30 | Atlanta Utd | 1.3 | 2–1 | 0.8 | Real Salt Lake | 42,509 | Mercedes-Benz Stadium | Drew Fischer | Match Report | |
| Tue | 2022-07-12 | 20:00 | Austin | 2.1 | 3–1 | 0.7 | Houston Dynamo | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-07-13 | 19:00 | Minnesota Utd | 1.1 | 1–1 | 0.9 | Sporting KC | 19,657 | Allianz Field | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-07-13 | 19:00 | LA Galaxy | 2.2 | 2–3 | 1.7 | SJ Earthquakes | 18,453 | Dignity Health Sports Park | Allen Chapman | Match Report | |
| Wed | 2022-07-13 | 19:00 | Chicago Fire | 1.3 | 2–0 | 0.4 | Toronto FC | 10,450 | Soldier Field | Lukasz Szpala | Match Report | |
| Wed | 2022-07-13 | 19:00 | Colorado Rapids | 2.4 | 1–1 | 0.7 | Orlando City | 12,538 | Dick's Sporting Goods Park | Fotis Bazakos | Match Report | |
| Wed | 2022-07-13 | 19:30 | Nashville SC | 1.3 | 1–0 | 0.8 | Seattle Sounders FC | 26,927 | Geodis Park | Rubiel Vazquez | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Cincinnati | 1.7 | 2–2 | 1.6 | Vancouver W'caps | 21,078 | TQL Stadium | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-07-13 | 20:00 | FC Dallas | 1.3 | 0–1 | 0.9 | NYCFC | 13,656 | Toyota Stadium | Victor Rivas | Match Report | |
| Wed | 2022-07-13 | 20:00 | Inter Miami | 0.8 | 1–2 | 1.4 | Philadelphia Union | 10,027 | DRV PNK Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-07-13 | 20:00 | D.C. United | 3.0 | 2–2 | 0.3 | Columbus Crew | 10,128 | Audi Field | Rosendo Mendoza | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-16 | 19:30 | CF Montréal | 2.2 | 1–0 | 0.3 | Toronto FC | 19,619 | Stade Saputo | Ted Unkel | Match Report | |
| Sat | 2022-07-16 | 19:30 | Philadelphia Union | 1.4 | 2–1 | 1.3 | NE Revolution | 18,257 | Subaru Park | Rubiel Vazquez | Match Report | |
| Sun | 2022-07-17 | 15:00 | Atlanta Utd | 2.2 | 1–1 | 0.2 | Orlando City | 42,526 | Mercedes-Benz Stadium | Victor Rivas | Match Report | |
| Sun | 2022-07-17 | 17:00 | NY Red Bulls | 0.9 | 0–1 | 1.4 | NYCFC | 25,219 | Red Bull Arena | Chris Penso | Match Report | |
| Sat | 2022-07-16 | 19:00 | Colorado Rapids | 1.6 | 2–0 | 1.0 | LA Galaxy | 17,975 | Dick's Sporting Goods Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-16 | 19:00 | Chicago Fire | 1.0 | 1–0 | 0.9 | Seattle Sounders FC | 13,601 | Soldier Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-16 | 19:00 | Minnesota Utd | 1.9 | 2–0 | 0.3 | D.C. United | 19,718 | Allianz Field | Jair Marrufo | Match Report | |
| Sun | 2022-07-17 | 19:30 | Columbus Crew | 2.2 | 2–0 | 1.0 | FC Cincinnati | 20,741 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-16 | 20:00 | FC Dallas | 2.1 | 1–1 | 0.7 | Austin | 16,833 | Toyota Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-07-16 | 20:30 | Inter Miami | 1.4 | 3–2 | 0.5 | Charlotte | 12,274 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Sun | 2022-07-17 | 18:30 | SJ Earthquakes | 2.2 | 1–2 | 1.3 | Houston Dynamo | 13,445 | PayPal Park | Tim Ford | Match Report | |
| Sun | 2022-07-17 | 19:30 | Nashville SC | 2.0 | 1–2 | 1.6 | LAFC | 30,109 | Geodis Park | Drew Fischer | Match Report | |
| Sun | 2022-07-17 | 19:30 | Real Salt Lake | 2.0 | 3–0 | 0.3 | Sporting KC | 20,132 | Rio Tinto Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-17 | 19:30 | Portland Timbers | 2.3 | 1–1 | 1.7 | Vancouver W'caps | 24,337 | Providence Park | Ramy Touchan | Match Report | |
| Sat | 2022-07-23 | 19:00 | NYCFC | 1.8 | 2–0 | 0.7 | Inter Miami | 23,277 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-07-23 | 19:30 | Columbus Crew | 1.0 | 0–0 | 0.2 | NE Revolution | 20,383 | Lower.com Field | Silviu Petrescu | Match Report | |
| Sat | 2022-07-23 | 19:30 | Orlando City | 0.7 | 0–1 | 0.8 | Philadelphia Union | 16,031 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-07-23 | 19:30 | Toronto FC | 1.2 | 4–0 | 0.7 | Charlotte | 29,067 | BMO Field | Filip Dujic | Match Report | |
| Sat | 2022-07-23 | 19:30 | FC Cincinnati | 1.4 | 1–1 | 1.6 | Nashville SC | 23,420 | TQL Stadium | Chris Penso | Match Report | |
| Sat | 2022-07-23 | 19:00 | Vancouver W'caps | 1.3 | 1–3 | 1.1 | Chicago Fire | 14,984 | BC Place Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-07-23 | 19:00 | Seattle Sounders FC | 2.8 | 2–1 | 1.3 | Colorado Rapids | 32,476 | Lumen Field | Rosendo Mendoza | Match Report | |
| Sat | 2022-07-23 | 19:30 | Portland Timbers | 1.7 | 2–1 | 1.3 | SJ Earthquakes | 23,795 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-07-23 | 19:30 | Sporting KC | 0.5 | 0–2 | 1.0 | LAFC | 20,142 | Children's Mercy Park | Lukasz Szpala | Match Report | |
| Sat | 2022-07-23 | 19:30 | Houston Dynamo | 1.5 | 1–2 | 1.3 | Minnesota Utd | 15,223 | PNC Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-07-23 | 20:00 | D.C. United | 1.5 | 1–2 | 1.5 | CF Montréal | 15,734 | Audi Field | Rubiel Vazquez | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-07-23 | 20:00 | Real Salt Lake | 2.1 | 0–1 | 0.7 | FC Dallas | 20,437 | Rio Tinto Stadium | Matt Conger | Match Report | |
| Sun | 2022-07-24 | 18:30 | LA Galaxy | 1.9 | 2–0 | 1.2 | Atlanta Utd | 24,122 | Dignity Health Sports Park | Marcos de Oliveira | Match Report | |
| Sun | 2022-07-24 | 19:00 | Austin | 1.6 | 3–4 | 0.9 | NY Red Bulls | 20,738 | Q2 Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-07-30 | 14:00 | Minnesota Utd | 2.3 | 4–4 | 1.3 | Portland Timbers | 19,792 | Allianz Field | Victor Rivas | Match Report | |
| Sat | 2022-07-30 | 16:00 | Chicago Fire | 1.0 | 0–0 | 1.3 | Atlanta Utd | 23,951 | Soldier Field | Tim Ford | Match Report | |
| Sat | 2022-07-30 | 19:30 | Philadelphia Union | 2.6 | 6–0 | 0.6 | Houston Dynamo | 19,089 | Subaru Park | Kevin Stott | Match Report | |
| Sat | 2022-07-30 | 19:30 | CF Montréal | 0.8 | 0–0 | 0.1 | NYCFC | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Fri | 2022-07-29 | 20:00 | LAFC | 1.6 | 2–1 | 0.9 | Seattle Sounders FC | 22,111 | Banc of California Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-07-31 | 17:00 | D.C. United | 1.0 | 2–1 | 1.6 | Orlando City | 15,805 | Audi Field | Armando Villarreal | Match Report | |
| Sat | 2022-07-30 | 19:00 | SJ Earthquakes | 1.5 | 2–2 | 1.6 | Real Salt Lake | 12,411 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-07-30 | 19:00 | Nashville SC | 1.8 | 1–1 | 1.3 | Vancouver W'caps | 26,578 | Geodis Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-07-30 | 19:30 | Sporting KC | 1.5 | 0–2 | 0.8 | Austin | 17,287 | Children's Mercy Park | Fotis Bazakos | Match Report | |
| Sat | 2022-07-30 | 20:00 | Inter Miami | 2.5 | 4–4 | 2.6 | FC Cincinnati | DRV PNK Stadium | Tori Penso | Match Report | ||
| Sat | 2022-07-30 | 20:00 | FC Dallas | 1.1 | 1–0 | 1.4 | LA Galaxy | 19,096 | Toyota Stadium | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-07-30 | 20:00 | NE Revolution | 0.6 | 0–0 | 1.7 | Toronto FC | 29,097 | Gillette Stadium | Ismir Pekmic | Match Report | |
| Tue | 2022-08-02 | 19:30 | NY Red Bulls | 2.4 | 4–5 | 1.5 | Colorado Rapids | 13,812 | Red Bull Arena | Drew Fischer | Match Report | |
| Wed | 2022-08-03 | 19:00 | Charlotte | 2.2 | 3–0 | 0.5 | D.C. United | 31,520 | Bank of America Stadium | Guido Gonzalez Jr. | Match Report | |
| Tue | 2022-08-02 | 19:00 | Seattle Sounders FC | 1.3 | 1–0 | 0.5 | FC Dallas | 32,207 | Lumen Field | Allen Chapman | Match Report | |
| Wed | 2022-08-03 | 19:30 | Columbus Crew | 1.3 | 1–2 | 1.2 | CF Montréal | 19,010 | Lower.com Field | Lukasz Szpala | Match Report | |
| Wed | 2022-08-03 | 19:30 | SJ Earthquakes | 1.3 | 0–1 | 1.4 | Inter Miami | 11,806 | PayPal Park | Mark Allatin | Match Report | |
| Wed | 2022-08-03 | 19:30 | Portland Timbers | 1.5 | 1–1 | 1.3 | Nashville SC | 23,101 | Providence Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-06 | 15:00 | Atlanta Utd | 1.0 | 2–1 | 1.2 | Seattle Sounders FC | 68,586 | Mercedes-Benz Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-08-06 | 19:00 | Charlotte | 1.3 | 2–3 | 2.2 | Chicago Fire | 32,538 | Bank of America Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-06 | 19:30 | Columbus Crew | 0.6 | 3–2 | 1.5 | NYCFC | 18,609 | Lower.com Field | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-06 | 19:30 | CF Montréal | 1.7 | 2–2 | 0.6 | Inter Miami | 18,007 | Stade Saputo | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-06 | 19:30 | D.C. United | 0.3 | 0–0 | 0.7 | NY Red Bulls | 16,258 | Audi Field | Pierre-Luc Lauziere | Match Report | |
| Sat | 2022-08-06 | 19:30 | FC Cincinnati | 1.7 | 3–1 | 1.3 | Philadelphia Union | 23,443 | TQL Stadium | Drew Fischer | Match Report | |
| Fri | 2022-08-05 | 19:30 | Vancouver W'caps | 1.0 | 2–1 | 0.9 | Houston Dynamo | 14,668 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-06 | 19:30 | Orlando City | 1.2 | 0–3 | 1.0 | NE Revolution | Exploria Stadium | Ramy Touchan | Match Report | ||
| Sat | 2022-08-06 | 19:00 | Colorado Rapids | 3.2 | 4–3 | 1.4 | Minnesota Utd | 14,738 | Dick's Sporting Goods Park | Ismir Pekmic | Match Report | |
| Sat | 2022-08-06 | 19:00 | Nashville SC | 2.4 | 3–4 | 1.8 | Toronto FC | 26,326 | Geodis Park | Allen Chapman | Match Report | |
| Sat | 2022-08-06 | 19:30 | Portland Timbers | 1.2 | 1–1 | 0.8 | FC Dallas | 24,114 | Providence Park | Ted Unkel | Match Report | |
| Sat | 2022-08-06 | 19:30 | Sporting KC | 3.3 | 4–2 | 1.5 | LA Galaxy | 18,101 | Children's Mercy Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-06 | 20:00 | Real Salt Lake | 0.7 | 1–4 | 1.4 | LAFC | 21,810 | Rio Tinto Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-06 | 20:00 | Austin | 2.6 | 3–3 | 0.8 | SJ Earthquakes | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-13 | 18:00 | NY Red Bulls | 0.5 | 0–1 | 0.2 | Orlando City | 18,218 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sat | 2022-08-13 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 1.3 | Atlanta Utd | 25,037 | TQL Stadium | Fotis Bazakos | Match Report | |
| Sat | 2022-08-13 | 19:30 | NE Revolution | 2.4 | 1–0 | 0.7 | D.C. United | 24,240 | Gillette Stadium | Malik Badawi | Match Report | |
| Sat | 2022-08-13 | 19:30 | Philadelphia Union | 2.6 | 4–1 | 1.3 | Chicago Fire | 18,682 | Subaru Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-13 | 19:30 | Toronto FC | 2.5 | 3–1 | 0.5 | Portland Timbers | 28,598 | BMO Field | Nima Saghafi | Match Report | |
| Sat | 2022-08-13 | 19:00 | Colorado Rapids | 1.2 | 1–1 | 1.3 | Columbus Crew | 13,254 | Dick's Sporting Goods Park | Jon Freemon | Match Report | |
| Sat | 2022-08-13 | 19:00 | LA Galaxy | 2.9 | 5–2 | 1.0 | Vancouver W'caps | 21,465 | Dignity Health Sports Park | Silviu Petrescu | Match Report | |
| Sat | 2022-08-13 | 19:30 | LAFC | 2.6 | 5–0 | 0.2 | Charlotte | 22,140 | Banc of California Stadium | Chris Penso | Match Report | |
| Sat | 2022-08-13 | 20:00 | Inter Miami | 1.9 | 3–2 | 2.2 | NYCFC | 11,419 | DRV PNK Stadium | Drew Fischer | Match Report | |
| Sat | 2022-08-13 | 20:00 | Houston Dynamo | 0.7 | 2–3 | 2.1 | CF Montréal | 21,284 | PNC Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-13 | 20:00 | FC Dallas | 1.6 | 4–1 | 0.6 | SJ Earthquakes | 15,106 | Toyota Stadium | Victor Rivas | Match Report | |
| Sat | 2022-08-13 | 20:00 | Austin | 1.3 | 4–3 | 2.6 | Sporting KC | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-14 | 19:00 | Seattle Sounders FC | 1.9 | 1–2 | 1.2 | Real Salt Lake | 33,093 | Lumen Field | Tim Ford | Match Report | |
| Sun | 2022-08-14 | 20:00 | Nashville SC | 1.5 | 1–2 | 1.0 | Minnesota Utd | 25,240 | Geodis Park | Alex Chilowicz | Match Report | |
| Wed | 2022-08-17 | 19:30 | Toronto FC | 1.7 | 2–2 | 1.1 | NE Revolution | 28,464 | BMO Field | Fotis Bazakos | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-08-16 | 19:30 | LAFC | 2.0 | 1–0 | 0.6 | D.C. United | 22,063 | Banc of California Stadium | Ramy Touchan | Match Report | |
| Wed | 2022-08-17 | 19:30 | Atlanta Utd | 0.9 | 1–2 | 0.9 | NY Red Bulls | 42,555 | Mercedes-Benz Stadium | Ted Unkel | Match Report | |
| Wed | 2022-08-17 | 19:00 | Vancouver W'caps | 1.0 | 2–1 | 2.4 | Colorado Rapids | 14,682 | BC Place Stadium | Filip Dujic | Match Report | |
| Wed | 2022-08-17 | 20:00 | NYCFC | 1.2 | 1–3 | 1.7 | Charlotte | 8,531 | Red Bull Arena | Jon Freemon | Match Report | |
| Wed | 2022-08-17 | 20:00 | FC Dallas | 0.9 | 1–0 | 0.5 | Philadelphia Union | 12,479 | Toyota Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-20 | 18:00 | NY Red Bulls | 1.6 | 1–1 | 0.4 | FC Cincinnati | 16,525 | Red Bull Arena | Ismail Elfath | Match Report | |
| Fri | 2022-08-19 | 19:00 | LA Galaxy | 1.5 | 3–3 | 2.5 | Seattle Sounders FC | 23,278 | Dignity Health Sports Park | Victor Rivas | Match Report | |
| Sat | 2022-08-20 | 19:30 | CF Montréal | 3.1 | 4–0 | 1.0 | NE Revolution | 19,619 | Stade Saputo | Chris Penso | Match Report | |
| Sat | 2022-08-20 | 19:30 | D.C. United | 1.5 | 0–6 | 3.6 | Philadelphia Union | 17,941 | Audi Field | Ted Unkel | Match Report | |
| Sun | 2022-08-21 | 17:00 | Chicago Fire | 1.7 | 0–2 | 1.0 | NYCFC | 11,720 | Soldier Field | Rosendo Mendoza | Match Report | |
| Sun | 2022-08-21 | 17:30 | Columbus Crew | 0.7 | 2–2 | 2.0 | Atlanta Utd | 17,461 | Lower.com Field | Joe Dickerson | Match Report | |
| Sun | 2022-08-21 | 18:30 | Sporting KC | 1.3 | 4–1 | 1.3 | Portland Timbers | 17,348 | Children's Mercy Park | Armando Villarreal | Match Report | |
| Sat | 2022-08-20 | 19:00 | Minnesota Utd | 2.1 | 2–1 | 1.4 | Austin | 19,829 | Allianz Field | Allen Chapman | Match Report | |
| Sun | 2022-08-21 | 19:00 | Charlotte | 0.7 | 1–2 | 1.4 | Orlando City | 30,855 | Bank of America Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-08-20 | 19:00 | Colorado Rapids | 0.7 | 1–1 | 0.4 | Houston Dynamo | 15,380 | Dick's Sporting Goods Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-08-20 | 19:00 | SJ Earthquakes | 0.9 | 2–1 | 1.3 | LAFC | 18,000 | PayPal Park | Michael Radchuk | Match Report | |
| Sat | 2022-08-20 | 20:00 | Real Salt Lake | 1.0 | 1–1 | 0.7 | Vancouver W'caps | 20,567 | Rio Tinto Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-08-20 | 20:00 | Inter Miami | 0.8 | 2–1 | 0.8 | Toronto FC | 14,388 | DRV PNK Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-08-21 | 19:30 | Nashville SC | 1.8 | 4–0 | 0.2 | FC Dallas | 25,571 | Geodis Park | Kevin Stott | Match Report | |
| Sat | 2022-08-27 | 14:30 | Minnesota Utd | 0.9 | 2–1 | 0.7 | Houston Dynamo | 19,624 | Allianz Field | Rosendo Mendoza | Match Report | |
| Fri | 2022-08-26 | 19:00 | Austin | 0.6 | 4–1 | 1.5 | LAFC | 20,738 | Q2 Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-08-27 | 19:00 | Charlotte | 1.1 | 0–2 | 0.7 | Toronto FC | 32,495 | Bank of America Stadium | Tim Ford | Match Report | |
| Sat | 2022-08-27 | 19:00 | NY Red Bulls | 1.2 | 3–1 | 1.9 | Inter Miami | 21,374 | Red Bull Arena | Fotis Bazakos | Match Report | |
| Fri | 2022-08-26 | 19:00 | Portland Timbers | 2.6 | 2–1 | 0.7 | Seattle Sounders FC | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sat | 2022-08-27 | 19:30 | FC Cincinnati | 1.4 | 2–2 | 0.4 | Columbus Crew | 25,037 | TQL Stadium | Kevin Stott | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-08-27 | 19:30 | Philadelphia Union | 5.7 | 6–0 | 0.8 | Colorado Rapids | 18,005 | Subaru Park | Allen Chapman | Match Report | |
| Sun | 2022-08-28 | 16:00 | Atlanta Utd | 2.1 | 3–2 | 1.1 | D.C. United | 42,561 | Mercedes-Benz Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-08-27 | 19:00 | Chicago Fire | 0.9 | 0–2 | 1.1 | CF Montréal | 13,907 | Soldier Field | Michael Radchuk | Match Report | |
| Sat | 2022-08-27 | 19:00 | Vancouver W'caps | 0.5 | 0–3 | 1.5 | Nashville SC | 16,351 | BC Place Stadium | Jon Freemon | Match Report | |
| Sun | 2022-08-28 | 19:30 | Orlando City | 1.2 | 2–1 | 0.5 | NYCFC | Exploria Stadium | Chris Penso | Match Report | ||
| Sat | 2022-08-27 | 19:30 | Sporting KC | 1.5 | 1–0 | 1.0 | SJ Earthquakes | 18,241 | Children's Mercy Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-08-27 | 20:00 | FC Dallas | 0.8 | 1–1 | 1.3 | Real Salt Lake | 15,573 | Toyota Stadium | Ramy Touchan | Match Report | |
| Sun | 2022-08-28 | 20:00 | NE Revolution | 1.9 | 1–2 | 0.9 | LA Galaxy | 21,517 | Gillette Stadium | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:00 | Philadelphia Union | 2.9 | 4–1 | 1.5 | Atlanta Utd | 18,214 | Subaru Park | Lukasz Szpala | Match Report | |
| Wed | 2022-08-31 | 19:30 | CF Montréal | 0.9 | 0–1 | 0.7 | NY Red Bulls | 15,075 | Stade Saputo | Victor Rivas | Match Report | |
| Wed | 2022-08-31 | 19:30 | Columbus Crew | 0.8 | 1–0 | 0.3 | Inter Miami | 18,034 | Lower.com Field | Armando Villarreal | Match Report | |
| Wed | 2022-08-31 | 19:30 | Toronto FC | 1.9 | 2–2 | 0.5 | LA Galaxy | 29,130 | BMO Field | Ted Unkel | Match Report | |
| Wed | 2022-08-31 | 19:30 | NE Revolution | 1.3 | 0–0 | 1.5 | Chicago Fire | 13,325 | Gillette Stadium | Marcos de Oliveira | Match Report | |
| Wed | 2022-08-31 | 19:30 | Nashville SC | 2.7 | 4–1 | 0.8 | Colorado Rapids | 24,127 | Geodis Park | Mark Allatin | Match Report | |
| Wed | 2022-08-31 | 19:30 | Houston Dynamo | 1.4 | 2–1 | 2.7 | LAFC | 21,284 | PNC Stadium | Matt Conger | Match Report | |
| Wed | 2022-08-31 | 19:30 | Real Salt Lake | 1.7 | 3–0 | 0.3 | Minnesota Utd | 20,358 | Rio Tinto Stadium | Drew Fischer | Match Report | |
| Wed | 2022-08-31 | 20:00 | NYCFC | 0.4 | 1–2 | 1.2 | D.C. United | 8,113 | Yankee Stadium | Ismir Pekmic | Match Report | |
| Wed | 2022-08-31 | 20:00 | Austin | 2.2 | 1–2 | 2.0 | Portland Timbers | 20,738 | Q2 Stadium | Chris Penso | Match Report | |
| Wed | 2022-08-31 | 22:00 | Orlando City | 3.4 | 3–2 | 0.5 | Seattle Sounders FC | 14,483 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sat | 2022-09-03 | 14:30 | Minnesota Utd | 1.2 | 0–3 | 0.9 | FC Dallas | 19,761 | Allianz Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-03 | 17:30 | Columbus Crew | 1.1 | 0–0 | 0.2 | Chicago Fire | 18,189 | Lower.com Field | Ismir Pekmic | Match Report | |
| Sat | 2022-09-03 | 19:00 | NY Red Bulls | 1.2 | 0–2 | 0.8 | Philadelphia Union | 16,247 | Red Bull Arena | Tim Ford | Match Report | |
| Sat | 2022-09-03 | 19:30 | FC Cincinnati | 1.1 | 2–0 | 0.9 | Charlotte | 21,165 | TQL Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-09-04 | 14:30 | Portland Timbers | 2.6 | 2–1 | 1.2 | Atlanta Utd | 24,438 | Providence Park | Jon Freemon | Match Report | |
| Sat | 2022-09-03 | 19:30 | Nashville SC | 1.8 | 3–0 | 0.9 | Austin | 25,293 | Geodis Park | Nima Saghafi | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-09-04 | 19:30 | Toronto FC | 1.7 | 3–4 | 2.1 | CF Montréal | 28,793 | BMO Field | Allen Chapman | Match Report | |
| Sun | 2022-09-04 | 19:30 | D.C. United | 1.7 | 0–0 | 1.0 | Colorado Rapids | 16,502 | Audi Field | Tori Penso | Match Report | |
| Sun | 2022-09-04 | 17:00 | LA Galaxy | 2.5 | 2–2 | 1.5 | Sporting KC | 20,104 | Dignity Health Sports Park | Ramy Touchan | Match Report | |
| Sun | 2022-09-04 | 18:00 | Seattle Sounders FC | 2.3 | 2–1 | 0.4 | Houston Dynamo | 33,621 | Lumen Field | Silviu Petrescu | Match Report | |
| Sun | 2022-09-04 | 18:30 | SJ Earthquakes | 0.7 | 2–0 | 1.4 | Vancouver W'caps | 13,211 | PayPal Park | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-04 | 19:30 | LAFC | 3.1 | 2–0 | 0.3 | Real Salt Lake | 22,199 | Banc of California Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-04 | 20:00 | NE Revolution | 0.4 | 3–0 | 2.1 | NYCFC | 17,793 | Gillette Stadium | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-09-07 | 20:00 | NYCFC | 1.5 | 1–1 | 0.2 | FC Cincinnati | 14,248 | Citi Field | Ted Unkel | Match Report | |
| Fri | 2022-09-09 | 19:30 | CF Montréal | 2.3 | 2–2 | 0.7 | Columbus Crew | 19,619 | Stade Saputo | Lukasz Szpala | Match Report | |
| Sat | 2022-09-10 | 13:00 | Charlotte | 0.7 | 1–0 | 0.8 | NYCFC | 30,159 | Bank of America Stadium | Victor Rivas | Match Report | |
| Sat | 2022-09-10 | 14:30 | Nashville SC | 1.4 | 1–1 | 2.6 | LA Galaxy | 28,753 | Geodis Park | Chris Penso | Match Report | |
| Sat | 2022-09-10 | 18:00 | NY Red Bulls | 1.6 | 2–1 | 0.5 | NE Revolution | 16,301 | Red Bull Arena | Alex Chilowicz | Match Report | |
| Sat | 2022-09-10 | 19:30 | Philadelphia Union | 2.8 | 5–1 | 0.4 | Orlando City | 19,079 | Subaru Park | Armando Villarreal | Match Report | |
| Sat | 2022-09-10 | 19:30 | Atlanta Utd | 4.1 | 4–2 | 2.4 | Toronto FC | 42,670 | Mercedes-Benz Stadium | Rosendo Mendoza | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Cincinnati | 3.8 | 6–0 | 0.9 | SJ Earthquakes | 22,557 | TQL Stadium | Ismir Pekmic | Match Report | |
| Sat | 2022-09-10 | 17:00 | Seattle Sounders FC | 1.1 | 3–0 | 1.1 | Austin | 34,721 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-10 | 19:00 | Chicago Fire | 1.7 | 3–1 | 1.1 | Inter Miami | 15,104 | SeatGeek Stadium | Matt Conger | Match Report | |
| Sat | 2022-09-10 | 19:00 | Portland Timbers | 1.1 | 1–0 | 2.4 | Minnesota Utd | 25,019 | Providence Park | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-10 | 19:30 | Real Salt Lake | 0.5 | 0–0 | 0.6 | D.C. United | 20,487 | Rio Tinto Stadium | Kevin Broadley | Match Report | |
| Sat | 2022-09-10 | 19:30 | Colorado Rapids | 2.2 | 3–1 | 0.9 | Vancouver W'caps | 14,036 | Dick's Sporting Goods Park | Kevin Stott | Match Report | |
| Sat | 2022-09-10 | 19:30 | Houston Dynamo | 1.3 | 0–0 | 1.3 | Sporting KC | 15,169 | PNC Stadium | Tori Penso | Match Report | |
| Sat | 2022-09-10 | 19:30 | FC Dallas | 0.9 | 2–1 | 1.1 | LAFC | 19,096 | Toyota Stadium | Jon Freemon | Match Report | |
| Tue | 2022-09-13 | 19:30 | CF Montréal | 0.9 | 3–2 | 1.7 | Chicago Fire | 11,535 | Stade Saputo | Ted Unkel | Match Report | |
| Wed | 2022-09-14 | 18:00 | Orlando City | 1.3 | 0–1 | 2.0 | Atlanta Utd | 15,340 | Exploria Stadium | Rubiel Vazquez | Match Report | |
| Tue | 2022-09-13 | 19:00 | Minnesota Utd | 1.6 | 1–1 | 1.1 | LAFC | 19,861 | Allianz Field | Tim Ford | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Tue | 2022-09-13 | 19:30 | Houston Dynamo | 4.4 | 3–1 | 2.1 | NE Revolution | 10,305 | PNC Stadium | Ismail Elfath | Match Report | |
| Tue | 2022-09-13 | 19:30 | Sporting KC | 1.9 | 3–0 | 0.4 | D.C. United | 15,106 | Children's Mercy Park | Rosendo Mendoza | Match Report | |
| Tue | 2022-09-13 | 20:00 | Inter Miami | 0.9 | 2–1 | 1.0 | Columbus Crew | 9,778 | DRV PNK Stadium | Jon Freemon | Match Report | |
| Wed | 2022-09-14 | 19:00 | Vancouver W'caps | 1.6 | 3–0 | 0.7 | LA Galaxy | 16,681 | BC Place Stadium | Fotis Bazakos | Match Report | |
| Wed | 2022-09-14 | 20:00 | Colorado Rapids | 0.7 | 2–1 | 1.2 | SJ Earthquakes | 11,938 | Dick's Sporting Goods Park | Pierre-Luc Lauziere | Match Report | |
| Wed | 2022-09-14 | 20:15 | Austin | 1.9 | 3–0 | 1.2 | Real Salt Lake | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 13:00 | NYCFC | 1.0 | 2–0 | 0.7 | NY Red Bulls | 30,151 | Yankee Stadium | Allen Chapman | Match Report | |
| Sat | 2022-09-17 | 15:30 | Atlanta Utd | 1.3 | 0–0 | 0.2 | Philadelphia Union | 42,521 | Mercedes-Benz Stadium | Guido Gonzalez Jr. | Match Report | |
| Sat | 2022-09-17 | 19:30 | Orlando City | 1.0 | 4–0 | 0.7 | Toronto FC | 17,189 | Exploria Stadium | Nima Saghafi | Match Report | |
| Sat | 2022-09-17 | 19:30 | NE Revolution | 0.8 | 0–1 | 1.3 | CF Montréal | 35,455 | Gillette Stadium | Rosendo Mendoza | Match Report | |
| Sun | 2022-09-18 | 13:00 | Columbus Crew | 1.1 | 1–1 | 0.8 | Portland Timbers | 20,421 | Lower.com Field | Victor Rivas | Match Report | |
| Sun | 2022-09-18 | 17:00 | D.C. United | 0.8 | 2–3 | 1.2 | Inter Miami | 14,284 | Audi Field | Ismail Elfath | Match Report | |
| Sat | 2022-09-17 | 19:00 | Vancouver W'caps | 1.2 | 2–1 | 0.6 | Seattle Sounders FC | 19,722 | BC Place Stadium | Ramy Touchan | Match Report | |
| Sat | 2022-09-17 | 19:00 | Chicago Fire | 1.6 | 2–3 | 2.1 | Charlotte | 21,450 | Soldier Field | Tori Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | Sporting KC | 1.6 | 4–1 | 0.4 | Minnesota Utd | 19,680 | Children's Mercy Park | Marcos de Oliveira | Match Report | |
| Sat | 2022-09-17 | 19:30 | Real Salt Lake | 1.6 | 1–2 | 0.6 | FC Cincinnati | 20,222 | Rio Tinto Stadium | Chris Penso | Match Report | |
| Sat | 2022-09-17 | 19:30 | SJ Earthquakes | 1.8 | 1–1 | 1.1 | FC Dallas | 12,355 | PayPal Park | Drew Fischer | Match Report | |
| Sat | 2022-09-17 | 19:30 | LA Galaxy | 1.9 | 4–1 | 1.1 | Colorado Rapids | 20,325 | Dignity Health Sports Park | Joe Dickerson | Match Report | |
| Sat | 2022-09-17 | 20:00 | Austin | 0.8 | 1–1 | 1.4 | Nashville SC | 20,738 | Q2 Stadium | Lukasz Szpala | Match Report | |
| Sun | 2022-09-18 | 19:30 | LAFC | 3.0 | 3–1 | 0.9 | Houston Dynamo | 22,131 | Banc of California Stadium | Kevin Stott | Match Report | |
| Sat | 2022-09-24 | 19:00 | SJ Earthquakes | 1.8 | 2–3 | 1.5 | LA Galaxy | 44,200 | Stanford Stadium | Alex Chilowicz | Match Report | |
| Tue | 2022-09-27 | 19:00 | Seattle Sounders FC | 0.4 | 1–1 | 2.0 | FC Cincinnati | 31,291 | Lumen Field | Rubiel Vazquez | Match Report | |
| Fri | 2022-09-30 | 19:30 | Toronto FC | 0.9 | 0–1 | 1.1 | Inter Miami | 27,703 | BMO Field | Silviu Petrescu | Match Report | |
| Sat | 2022-10-01 | 13:30 | NE Revolution | 2.4 | 2–1 | 1.3 | Atlanta Utd | 33,421 | Gillette Stadium | Armando Villarreal | Match Report | |
| Sat | 2022-10-01 | 15:30 | Colorado Rapids | 0.6 | 1–0 | 0.8 | FC Dallas | 17,193 | Dick's Sporting Goods Park | Chris Penso | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sat | 2022-10-01 | 17:30 | Charlotte | 2.9 | 4–0 | 0.8 | Philadelphia Union | 43,860 | Bank of America Stadium | Jon Freemon | Match Report | |
| Sat | 2022-10-01 | 19:30 | Columbus Crew | 1.1 | 2–1 | 0.5 | NY Red Bulls | 20,757 | Lower.com Field | Marcos de Oliveira | Match Report | |
| Sat | 2022-10-01 | 19:30 | FC Cincinnati | 2.5 | 2–3 | 1.6 | Chicago Fire | 25,316 | TQL Stadium | Lukasz Szpala | Match Report | |
| Sat | 2022-10-01 | 19:30 | CF Montréal | 2.0 | 1–0 | 0.6 | D.C. United | 19,619 | Stade Saputo | Ramy Touchan | Match Report | |
| Sun | 2022-10-02 | 12:00 | Portland Timbers | 1.2 | 1–2 | 1.0 | LAFC | 25,218 | Providence Park | Ismail Elfath | Match Report | |
| Sun | 2022-10-02 | 13:00 | NYCFC | 1.9 | 2–1 | 1.0 | Orlando City | 13,169 | Red Bull Arena | Joe Dickerson | Match Report | |
| Sun | 2022-10-02 | 16:00 | Sporting KC | 1.7 | 1–0 | 1.1 | Seattle Sounders FC | 19,439 | Children's Mercy Park | Ted Unkel | Match Report | |
| Sat | 2022-10-01 | 19:00 | Vancouver W'caps | 1.5 | 2–0 | 1.4 | Austin | 19,292 | BC Place Stadium | Tim Ford | Match Report | |
| Sat | 2022-10-01 | 19:00 | SJ Earthquakes | 1.6 | 2–0 | 1.2 | Minnesota Utd | 15,709 | PayPal Park | Nima Saghafi | Match Report | |
| Sat | 2022-10-01 | 19:30 | LA Galaxy | 2.4 | 1–1 | 1.6 | Real Salt Lake | 26,674 | Dignity Health Sports Park | Kevin Stott | Match Report | |
| Sun | 2022-10-02 | 19:30 | Nashville SC | 1.3 | 1–2 | 1.9 | Houston Dynamo | 28,720 | Geodis Park | Guido Gonzalez Jr. | Match Report | |
| Wed | 2022-10-05 | 19:00 | Charlotte | 2.4 | 2–2 | 1.2 | Columbus Crew | 34,122 | Bank of America Stadium | Matt Conger | Match Report | |
| Wed | 2022-10-05 | 20:00 | Inter Miami | 2.0 | 4–1 | 0.8 | Orlando City | 15,228 | DRV PNK Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 13:30 | Chicago Fire | 2.1 | 1–1 | 1.5 | NE Revolution | 14,357 | SeatGeek Stadium | Michael Radchuk | Match Report | |
| Sun | 2022-10-09 | 14:00 | LAFC | 4.5 | 0–1 | 1.2 | Nashville SC | 22,205 | Banc of California Stadium | Ted Unkel | Match Report | |
| Sun | 2022-10-09 | 14:00 | Seattle Sounders FC | 1.3 | 2–2 | 1.5 | SJ Earthquakes | 33,910 | Lumen Field | Marcos de Oliveira | Match Report | |
| Sun | 2022-10-09 | 14:30 | Philadelphia Union | 2.0 | 4–0 | 0.4 | Toronto FC | 19,228 | Subaru Park | Lukasz Szpala | Match Report | |
| Sun | 2022-10-09 | 14:30 | Inter Miami | 0.8 | 1–3 | 2.4 | CF Montréal | 15,635 | DRV PNK Stadium | Joe Dickerson | Match Report | |
| Sun | 2022-10-09 | 14:30 | Atlanta Utd | 1.5 | 1–2 | 1.4 | NYCFC | 43,312 | Mercedes-Benz Stadium | Chris Penso | Match Report | |
| Sun | 2022-10-09 | 14:30 | NY Red Bulls | 0.9 | 2–0 | 1.0 | Charlotte | 23,672 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| Sun | 2022-10-09 | 14:30 | D.C. United | 0.4 | 2–5 | 2.1 | FC Cincinnati | 19,325 | Audi Field | Tim Ford | Match Report | |
| Sun | 2022-10-09 | 14:30 | Orlando City | 1.1 | 2–1 | 0.9 | Columbus Crew | 21,693 | Exploria Stadium | Alex Chilowicz | Match Report | |
| Sun | 2022-10-09 | 15:00 | Real Salt Lake | 1.7 | 3–1 | 0.8 | Portland Timbers | 21,333 | Rio Tinto Stadium | Armando Villarreal | Match Report | |
| Sun | 2022-10-09 | 16:00 | FC Dallas | 1.3 | 2–1 | 0.9 | Sporting KC | 19,096 | Toyota Stadium | Victor Rivas | Match Report | |
| Sun | 2022-10-09 | 16:00 | Houston Dynamo | 0.6 | 1–3 | 2.3 | LA Galaxy | 21,284 | PNC Stadium | Drew Fischer | Match Report | |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
| Sun | 2022-10-09 | 16:00 | Austin | 1.6 | 1–1 | 1.2 | Colorado Rapids | 20,738 | Q2 Stadium | Pierre-Luc Lauziere | Match Report | |
| Sun | 2022-10-09 | 16:00 | Minnesota Utd | 0.9 | 2–0 | 0.6 | Vancouver W'caps | 19,941 | Allianz Field | Allen Chapman | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Round | Sat | 2022-10-15 | 12:00 | NY Red Bulls | 1.1 | 1–2 | 2.1 | FC Cincinnati | 17,113 | Red Bull Arena | Alex Chilowicz | Match Report | |
| First Round | Sat | 2022-10-15 | 12:00 | LA Galaxy | 1.2 | 1–0 | 0.8 | Nashville SC | 22,280 | Dignity Health Sports Park | Armando Villarreal | Match Report | |
| First Round | Sun | 2022-10-16 | 14:00 | Austin | 4.2 | (3) 2–2 (1) | 1.5 | Real Salt Lake | 20,738 | Q2 Stadium | Victor Rivas | Match Report | Austin won on penalty kicks following extra time |
| First Round | Mon | 2022-10-17 | 19:00 | NYCFC | 2.9 | 3–0 | 0.6 | Inter Miami | 18,066 | Red Bull Arena | Rubiel Vazquez | Match Report | |
| First Round | Sun | 2022-10-16 | 20:00 | CF Montréal | 1.6 | 2–0 | 0.7 | Orlando City | 19,619 | Stade Saputo | Ismail Elfath | Match Report | |
| First Round | Mon | 2022-10-17 | 20:30 | FC Dallas | 1.5 | (5) 1–1 (4) | 0.4 | Minnesota Utd | 19,096 | Toyota Stadium | Ted Unkel | Match Report | FC Dallas won on penalty kicks following extra time |
| Conference Semifinals | Thu | 2022-10-20 | 19:00 | LAFC | 2.5 | 3–2 | 0.4 | LA Galaxy | 22,305 | Banc of California Stadium | Allen Chapman | Match Report | |
| Conference Semifinals | Thu | 2022-10-20 | 20:00 | Philadelphia Union | 1.8 | 1–0 | 0.8 | FC Cincinnati | 19,289 | Subaru Park | Tim Ford | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 13:00 | CF Montréal | 2.6 | 1–3 | 1.8 | NYCFC | 19,619 | Stade Saputo | Drew Fischer | Match Report | |
| Conference Semifinals | Sun | 2022-10-23 | 19:00 | Austin | 1.4 | 2–1 | 0.6 | FC Dallas | 20,738 | Q2 Stadium | Joe Dickerson | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 12:00 | LAFC | 2.1 | 3–0 | 0.3 | Austin | 22,175 | Banc of California Stadium | Armando Villarreal | Match Report | |
| Conference Finals | Sun | 2022-10-30 | 20:00 | Philadelphia Union | 1.7 | 3–1 | 0.6 | NYCFC | 19,770 | Subaru Park | Allen Chapman | Match Report | |
| MLS Cup | Sat | 2022-11-05 | 13:00 | LAFC | 1.0 | (3) 3–3 (0) | 1.6 | Philadelphia Union | 22,384 | Banc of California Stadium | Ismail Elfath | Match Report | LAFC won on penalty kicks following extra time |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
Note that player records are likely not complete for their careers. Players may come from or move to leagues we don't currently cover. This issue will go down over time, as we add new leagues and seasons. We will never in the future have less data than we do today.
You can sign up to receive an e-mail when new countries and features launch.
For more information, see our Launch Blog Post, the overall leagues/competition page with details on leagues and seasons we include, or our About Page. Let us know if you find an issue or have a suggestion.
FBref is one of seven Sports-Reference.com sites.
We're Social...for Statheads
Every Sports Reference Social Media Account
Site Last Updated: Saturday, February 1, 1:17PM
Question, Comment, Feedback, or Correction?
Subscribe to our Free Email Newsletter
Subscribe to Stathead FBref: Get your first month FREE
Your All-Access Ticket to the FBref Database
Do you have a sports website? Or write about sports? We have tools and resources that can help you use sports data. Find out more.