Scores & Fixtures 2021-2022 Serie B
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular season | 1 | Fri | 2021-08-20 | 20:30 | Frosinone | 2.0 | 2–2 | 1.4 | Parma | 5,094 | Stadio Benito Stirpe | Massimiliano Irrati | Match Report | |
| Regular season | 1 | Sat | 2021-08-21 | 18:00 | Pordenone | 0.7 | 0–1 | 0.9 | Perugia | 955 | Stadio Comunale G.Teghil | Luca Massimi | Match Report | |
| Regular season | 1 | Sat | 2021-08-21 | 20:30 | Cittadella | 1.9 | 1–0 | 0.5 | Vicenza Virtus | 1,788 | Stadio Pier Cesare Tombolato | Matteo Marcenaro | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 18:00 | US Reggina | 0.9 | 0–0 | 0.4 | Monza | 5,825 | Stadio Oreste Granillo | Antonio Giua | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 18:00 | Ternana | 1.5 | 0–2 | 2.2 | Brescia | 3,359 | Stadio Libero Liberati | Gianpiero Miele | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 20:30 | Pisa | 0.8 | 1–0 | 1.5 | SPAL | 2,933 | Arena Garibaldi - Stadio Romeo Anconetan... | Giacomo Camplone | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 20:30 | Benevento | 2.1 | 4–3 | 2.2 | Alessandria | 2,869 | Stadio Ciro Vigorito | Marco Di Bello | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 20:30 | Cremonese | 2.3 | 3–0 | 1.5 | Lecce | 2,372 | Stadio Giovanni Zini | Niccolò Baroni | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 20:30 | Crotone | 1.6 | 2–2 | 2.5 | Como | 2,500 | Stadio Ezio Scida | Daniele Doveri | Match Report | |
| Regular season | 1 | Sun | 2021-08-22 | 20:30 | Ascoli | 1.1 | 1–0 | 0.4 | Cosenza | 3,852 | Stadio Cino e Lillo Del Duca | Lorenzo Maggioni | Match Report | |
| Regular season | 2 | Fri | 2021-08-27 | 18:00 | Pisa | 2.2 | 2–0 | 0.3 | Alessandria | 3,882 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| Regular season | 2 | Fri | 2021-08-27 | 20:30 | Brescia | 2.7 | 5–1 | 0.9 | Cosenza | 4,000 | Stadio Mario Rigamonti | Francesco Meraviglia | Match Report | |
| Regular season | 2 | Sat | 2021-08-28 | 18:00 | Vicenza Virtus | 0.5 | 0–2 | 2.1 | Frosinone | 2,844 | Stadio Romeo Menti | Daniele Minelli | Match Report | |
| Regular season | 2 | Sat | 2021-08-28 | 20:30 | Perugia | 1.9 | 2–3 | 2.0 | Ascoli | 3,400 | Stadio Renato Curi | Paolo Valeri | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 18:00 | Cittadella | 2.5 | 4–2 | 1.3 | Crotone | 1,200 | Stadio Pier Cesare Tombolato | Luca Zufferli | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 20:30 | Monza | 1.4 | 1–0 | 0.6 | Cremonese | 2,501 | U-Power Stadium | Marco Piccinini | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 20:30 | Parma | 1.2 | 1–0 | 1.7 | Benevento | 3,550 | Stadio Ennio Tardini | Andrea Colombo | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 20:30 | SPAL | 3.1 | 5–0 | 0.3 | Pordenone | 2,537 | Stadio Paolo Mazza | Giovanni Ayroldi | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 20:30 | US Reggina | 3.0 | 3–2 | 1.7 | Ternana | 5,005 | Stadio Oreste Granillo | Antonio Di Martino | Match Report | |
| Regular season | 2 | Sun | 2021-08-29 | 20:30 | Lecce | 1.3 | 1–1 | 1.1 | Como | 6,192 | Stadio Comunale Via Del Mare | Matteo Marchetti | Match Report | |
| Regular season | 3 | Fri | 2021-09-10 | 20:30 | Benevento | 1.3 | 0–0 | 1.7 | Lecce | 5,120 | Stadio Ciro Vigorito | Alberto Santoro | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 14:00 | SPAL | 1.2 | 1–1 | 1.3 | Monza | 3,726 | Stadio Paolo Mazza | Luca Massimi | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 14:00 | Frosinone | 0.6 | 0–0 | 0.6 | Perugia | 5,594 | Stadio Benito Stirpe | Matteo Gariglio | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 14:00 | Como | 1.5 | 0–1 | 1.5 | Ascoli | 2,297 | Stadio Giuseppe Sinigaglia | Antonio Giua | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 14:00 | Alessandria | 1.7 | 1–3 | 1.5 | Brescia | 1,491 | Stadio Giuseppe Moccagatta | Francesco Fourneau | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 16:15 | Ternana | 1.5 | 1–4 | 1.0 | Pisa | 4,003 | Stadio Libero Liberati | Fabio Maresca | Match Report | |
| Regular season | 3 | Sat | 2021-09-11 | 18:30 | Crotone | 0.8 | 1–1 | 0.6 | US Reggina | 2,220 | Stadio Ezio Scida | Michael Fabbri | Match Report | |
| Regular season | 3 | Sun | 2021-09-12 | 14:00 | Cosenza | 0.9 | 2–1 | 1.1 | Vicenza Virtus | 3,026 | Stadio San Vito | Alessandro Prontera | Match Report | |
| Regular season | 3 | Sun | 2021-09-12 | 16:15 | Cremonese | 0.5 | 2–0 | 0.9 | Cittadella | 2,817 | Stadio Giovanni Zini | Daniele Paterna | Match Report | |
| Regular season | 3 | Sun | 2021-09-12 | 20:30 | Pordenone | 0.8 | 0–4 | 1.9 | Parma | 1,830 | Stadio Comunale G.Teghil | Lorenzo Maggioni | Match Report | |
| Regular season | 4 | Fri | 2021-09-17 | 18:00 | Como | 0.9 | 0–2 | 1.6 | Frosinone | 1,645 | Stadio Giuseppe Sinigaglia | Matteo Marcenaro | Match Report | |
| Regular season | 4 | Fri | 2021-09-17 | 20:30 | Brescia | 1.4 | 2–2 | 0.8 | Crotone | 4,250 | Stadio Mario Rigamonti | Giacomo Camplone | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 14:00 | Lecce | 2.2 | 3–2 | 0.7 | Alessandria | 5,003 | Stadio Comunale Via Del Mare | Piero Giacomelli | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 14:00 | Perugia | 1.8 | 1–1 | 0.8 | Cosenza | 3,500 | Stadio Renato Curi | Gianpiero Miele | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 14:00 | US Reggina | 2.2 | 2–1 | 1.6 | SPAL | 4,773 | Stadio Oreste Granillo | Niccolò Baroni | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 14:00 | Ascoli | 0.5 | 0–2 | 1.8 | Benevento | 4,545 | Stadio Cino e Lillo Del Duca | Eugenio Abbattista | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 14:00 | Monza | 1.8 | 1–1 | 0.9 | Ternana | 2,332 | U-Power Stadium | Luca Zufferli | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 16:15 | Vicenza Virtus | 0.5 | 1–3 | 0.9 | Pisa | 3,372 | Stadio Romeo Menti | Davide Massa | Match Report | |
| Regular season | 4 | Sat | 2021-09-18 | 18:30 | Cittadella | 0.9 | 1–0 | 0.6 | Pordenone | 1,326 | Stadio Pier Cesare Tombolato | Andrea Colombo | Match Report | |
| Regular season | 4 | Sun | 2021-09-19 | 20:30 | Parma | 0.5 | 1–2 | 2.4 | Cremonese | 5,581 | Stadio Ennio Tardini | Manuel Volpi | Match Report | |
| Regular season | 5 | Mon | 2021-09-20 | 20:30 | Frosinone | 1.9 | 2–2 | 2.6 | Brescia | 6,213 | Stadio Benito Stirpe | Federico Dionisi | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 18:00 | Benevento | 1.9 | 4–1 | 1.8 | Cittadella | 2,994 | Stadio Ciro Vigorito | Cosso Cosso | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 18:00 | Alessandria | 2.1 | 1–3 | 1.3 | Ascoli | 1,912 | Stadio Giuseppe Moccagatta | Daniele Minelli | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 20:30 | SPAL | 1.4 | 3–2 | 0.6 | Vicenza Virtus | 3,599 | Stadio Paolo Mazza | Antonio Di Martino | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 20:30 | Cosenza | 0.2 | 2–0 | 1.0 | Como | 4,500 | Stadio San Vito | Juan Sacchi | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 20:30 | Crotone | 1.3 | 0–3 | 1.7 | Lecce | 2,277 | Stadio Ezio Scida | Daniele Paterna | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 20:30 | Pisa | 1.7 | 2–1 | 1.1 | Monza | 4,635 | Arena Garibaldi - Stadio Romeo Anconetan... | Luca Pairetto | Match Report | |
| Regular season | 5 | Tue | 2021-09-21 | 20:30 | Pordenone | 0.8 | 1–1 | 1.4 | US Reggina | 815 | Stadio Comunale G.Teghil | Francesco Meraviglia | Match Report | |
| Regular season | 5 | Wed | 2021-09-22 | 18:00 | Ternana | 1.9 | 3–1 | 1.0 | Parma | 4,611 | Stadio Libero Liberati | Marco Serra | Match Report | |
| Regular season | 5 | Wed | 2021-09-22 | 20:30 | Cremonese | 2.5 | 0–3 | 1.3 | Perugia | 3,188 | Stadio Giovanni Zini | Matteo Marchetti | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 14:00 | Monza | 2.4 | 3–1 | 1.3 | Pordenone | 2,011 | U-Power Stadium | Niccolò Baroni | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 14:00 | Cittadella | 1.0 | 1–2 | 1.4 | Lecce | 1,773 | Stadio Pier Cesare Tombolato | Matteo Gariglio | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 14:00 | Como | 1.4 | 1–1 | 1.0 | Benevento | 2,189 | Stadio Giuseppe Sinigaglia | Luca Zufferli | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 14:00 | Ascoli | 1.5 | 2–3 | 2.6 | Brescia | 3,901 | Stadio Cino e Lillo Del Duca | Luca Massimi | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 16:15 | US Reggina | 1.1 | 0–0 | 0.9 | Frosinone | 5,034 | Stadio Oreste Granillo | Simone Sozza | Match Report | |
| Regular season | 6 | Sat | 2021-09-25 | 18:30 | Cosenza | 0.3 | 1–0 | 1.0 | Crotone | 7,554 | Stadio San Vito | Daniele Chiffi | Match Report | |
| Regular season | 6 | Sun | 2021-09-26 | 14:00 | Perugia | 1.3 | 1–1 | 1.1 | Alessandria | 3,179 | Stadio Renato Curi | Valerio Marini | Match Report | |
| Regular season | 6 | Sun | 2021-09-26 | 16:15 | Parma | 2.0 | 1–1 | 1.2 | Pisa | 7,245 | Stadio Ennio Tardini | Alessandro Prontera | Match Report | |
| Regular season | 6 | Sun | 2021-09-26 | 20:30 | Vicenza Virtus | 1.0 | 0–1 | 1.4 | Cremonese | 2,927 | Stadio Romeo Menti | Alberto Santoro | Match Report | |
| Regular season | 6 | Sun | 2021-09-26 | 20:30 | Ternana | 0.7 | 1–0 | 1.3 | SPAL | 4,369 | Stadio Libero Liberati | Matteo Marcenaro | Match Report | |
| Regular season | 7 | Fri | 2021-10-01 | 20:30 | Lecce | 1.8 | 3–0 | 0.3 | Monza | 8,442 | Stadio Comunale Via Del Mare | Eugenio Abbattista | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 14:00 | Cremonese | 1.0 | 2–0 | 1.2 | Ternana | 2,813 | Stadio Giovanni Zini | Cosso Cosso | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 14:00 | Crotone | 1.1 | 2–2 | 1.5 | Ascoli | 1,490 | Stadio Ezio Scida | Antonio Di Martino | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 14:00 | Alessandria | 0.9 | 1–0 | 0.2 | Cosenza | 2,345 | Stadio Giuseppe Moccagatta | Michael Fabbri | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 14:00 | Frosinone | 1.1 | 0–1 | 2.8 | Cittadella | 5,509 | Stadio Benito Stirpe | Francesco Meraviglia | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 16:15 | Pisa | 1.6 | 2–0 | 1.8 | US Reggina | 5,029 | Arena Garibaldi - Stadio Romeo Anconetan... | Andrea Colombo | Match Report | |
| Regular season | 7 | Sat | 2021-10-02 | 18:30 | SPAL | 1.9 | 2–2 | 1.4 | Parma | 3,720 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| Regular season | 7 | Sun | 2021-10-03 | 14:00 | Brescia | 2.1 | 2–4 | 2.2 | Como | 5,000 | Stadio Mario Rigamonti | Gianpiero Miele | Match Report | |
| Regular season | 7 | Sun | 2021-10-03 | 16:15 | Pordenone | 1.3 | 2–4 | 3.3 | Vicenza Virtus | 1,512 | Stadio Comunale G.Teghil | Antonio Rapuano | Match Report | |
| Regular season | 7 | Sun | 2021-10-03 | 20:30 | Benevento | 1.0 | 0–0 | 1.8 | Perugia | 4,326 | Stadio Ciro Vigorito | Livio Marinelli | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 14:00 | Vicenza Virtus | 1.0 | 0–1 | 1.0 | US Reggina | 5,251 | Stadio Romeo Menti | Matteo Gariglio | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 14:00 | Crotone | 1.5 | 2–1 | 2.6 | Pisa | 1,962 | Stadio Ezio Scida | Niccolò Baroni | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 14:00 | Ascoli | 1.0 | 1–1 | 1.5 | Lecce | 4,390 | Stadio Cino e Lillo Del Duca | Federico Dionisi | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 14:00 | Pordenone | 1.4 | 1–3 | 1.7 | Ternana | 857 | Stadio Comunale G.Teghil | Daniele Minelli | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 16:15 | Cosenza | 0.9 | 1–1 | 2.0 | Frosinone | 5,414 | Stadio San Vito | Francesco Fourneau | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 16:15 | Perugia | 1.2 | 1–0 | 0.3 | Brescia | 4,369 | Stadio Renato Curi | Marco Guida | Match Report | |
| Regular season | 8 | Sat | 2021-10-16 | 18:30 | Como | 1.4 | 2–0 | 0.4 | Alessandria | 2,869 | Stadio Giuseppe Sinigaglia | Ivan Pezzuto | Match Report | |
| Regular season | 8 | Sun | 2021-10-17 | 14:00 | Cremonese | 1.4 | 1–1 | 1.2 | Benevento | 4,302 | Stadio Giovanni Zini | Matteo Marcenaro | Match Report | |
| Regular season | 8 | Sun | 2021-10-17 | 16:15 | Parma | 1.3 | 0–0 | 0.8 | Monza | 7,555 | Stadio Ennio Tardini | Fabio Maresca | Match Report | |
| Regular season | 8 | Sun | 2021-10-17 | 20:30 | Cittadella | 0.8 | 0–0 | 0.8 | SPAL | 2,233 | Stadio Pier Cesare Tombolato | Maria Sole Ferrieri Caputi | Match Report | |
| Regular season | 9 | Fri | 2021-10-22 | 20:30 | Alessandria | 2.8 | 1–0 | 0.8 | Crotone | 2,528 | Stadio Giuseppe Moccagatta | Alberto Santoro | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 14:00 | Benevento | 3.2 | 3–0 | 0.7 | Cosenza | 3,930 | Stadio Ciro Vigorito | Davide Ghersini | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 14:00 | Ternana | 2.2 | 5–0 | 1.2 | Vicenza Virtus | 3,723 | Stadio Libero Liberati | Manuel Volpi | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 14:00 | Monza | 0.9 | 1–0 | 1.1 | Cittadella | 2,521 | U-Power Stadium | Gianluca Manganiello | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 14:00 | Lecce | 1.2 | 0–0 | 0.3 | Perugia | 6,665 | Stadio Comunale Via Del Mare | Antonio Giua | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 16:15 | Frosinone | 1.6 | 2–1 | 0.7 | Ascoli | 6,164 | Stadio Benito Stirpe | Lorenzo Maggioni | Match Report | |
| Regular season | 9 | Sat | 2021-10-23 | 18:30 | Brescia | 0.5 | 1–0 | 1.5 | Cremonese | 6,500 | Stadio Mario Rigamonti | Gianluca Aureliano | Match Report | |
| Regular season | 9 | Sun | 2021-10-24 | 14:00 | Pisa | 0.5 | 1–1 | 1.7 | Pordenone | 6,388 | Arena Garibaldi - Stadio Romeo Anconetan... | Paride Tremolada | Match Report | |
| Regular season | 9 | Sun | 2021-10-24 | 16:15 | US Reggina | 2.9 | 2–1 | 0.6 | Parma | 8,693 | Stadio Oreste Granillo | Luca Zufferli | Match Report | |
| Regular season | 9 | Sun | 2021-10-24 | 20:30 | SPAL | 1.5 | 1–1 | 1.6 | Como | 4,915 | Stadio Paolo Mazza | Eugenio Abbattista | Match Report | |
| Regular season | 10 | Wed | 2021-10-27 | 18:00 | Cosenza | 1.0 | 3–1 | 2.6 | Ternana | 3,149 | Stadio San Vito | Andrea Colombo | Match Report | |
| Regular season | 10 | Wed | 2021-10-27 | 20:30 | Vicenza Virtus | 0.7 | 1–1 | 1.0 | Monza | 4,312 | Stadio Romeo Menti | Luca Pairetto | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 18:00 | Brescia | 2.1 | 1–1 | 0.7 | Lecce | 5,938 | Stadio Mario Rigamonti | Massimiliano Irrati | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 18:00 | Alessandria | 0.7 | 1–1 | 1.4 | Frosinone | 2,432 | Stadio Giuseppe Moccagatta | Cosso Cosso | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 18:00 | Ascoli | 0.9 | 0–1 | 0.5 | SPAL | 3,979 | Stadio Cino e Lillo Del Duca | Gianpiero Miele | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 20:30 | Cremonese | 1.6 | 1–1 | 1.2 | Pisa | 5,543 | Stadio Giovanni Zini | Daniele Orsato | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 20:30 | Cittadella | 2.0 | 1–2 | 0.5 | Parma | 3,161 | Stadio Pier Cesare Tombolato | Federico Dionisi | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 20:30 | Crotone | 0.5 | 0–2 | 1.7 | Benevento | 1,949 | Stadio Ezio Scida | Francesco Meraviglia | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 20:30 | Perugia | 1.3 | 0–2 | 0.6 | US Reggina | 4,223 | Stadio Renato Curi | Giacomo Camplone | Match Report | |
| Regular season | 10 | Thu | 2021-10-28 | 20:30 | Como | 1.6 | 1–0 | 1.5 | Pordenone | 2,065 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 12:30 | Benevento | 0.9 | 0–1 | 0.9 | Brescia | 4,453 | Stadio Ciro Vigorito | Piero Giacomelli | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | SPAL | 1.7 | 1–2 | 3.1 | Perugia | 5,134 | Stadio Paolo Mazza | Luca Zufferli | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | Ternana | 2.4 | 1–2 | 0.9 | Como | 3,426 | Stadio Libero Liberati | Rosario Abisso | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | Frosinone | 1.7 | 2–1 | 2.0 | Crotone | 5,673 | Stadio Benito Stirpe | Eugenio Abbattista | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | Monza | 0.6 | 1–0 | 0.6 | Alessandria | 3,145 | U-Power Stadium | Matteo Gariglio | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | US Reggina | 1.8 | 0–1 | 1.6 | Cittadella | 6,292 | Stadio Oreste Granillo | Daniele Minelli | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 15:00 | Lecce | 1.8 | 3–1 | 0.4 | Cosenza | 6,556 | Stadio Comunale Via Del Mare | Alberto Santoro | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 18:00 | Pisa | 0.7 | 1–1 | 1.6 | Ascoli | 4,732 | Arena Garibaldi - Stadio Romeo Anconetan... | Matteo Marcenaro | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 18:00 | Pordenone | 1.0 | 2–2 | 0.9 | Cremonese | 917 | Stadio Comunale G.Teghil | Lorenzo Maggioni | Match Report | |
| Regular season | 11 | Mon | 2021-11-01 | 18:00 | Parma | 0.8 | 1–0 | 0.7 | Vicenza Virtus | 5,116 | Stadio Ennio Tardini | Niccolò Baroni | Match Report | |
| Regular season | 12 | Fri | 2021-11-05 | 20:30 | Cosenza | 1.2 | 0–1 | 0.8 | US Reggina | 8,506 | Stadio San Vito | Antonio Di Martino | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 14:00 | Ascoli | 1.7 | 2–1 | 1.1 | Vicenza Virtus | 3,306 | Stadio Cino e Lillo Del Duca | Daniele Paterna | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 14:00 | Cremonese | 1.5 | 1–1 | 1.1 | SPAL | 3,868 | Stadio Giovanni Zini | Andrea Colombo | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 14:00 | Como | 2.0 | 4–1 | 1.5 | Perugia | 2,471 | Stadio Giuseppe Sinigaglia | Cosso Cosso | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 14:00 | Alessandria | 1.4 | 0–2 | 0.9 | Ternana | 2,198 | Stadio Giuseppe Moccagatta | Giacomo Camplone | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 16:15 | Brescia | 0.6 | 1–0 | 0.7 | Pordenone | 4,900 | Stadio Mario Rigamonti | Manuel Volpi | Match Report | |
| Regular season | 12 | Sat | 2021-11-06 | 18:30 | Benevento | 1.4 | 1–4 | 2.3 | Frosinone | 2,467 | Stadio Ciro Vigorito | Matteo Marchetti | Match Report | |
| Regular season | 12 | Sun | 2021-11-07 | 14:00 | Lecce | 2.5 | 4–0 | 0.7 | Parma | 18,765 | Stadio Comunale Via Del Mare | Davide Ghersini | Match Report | |
| Regular season | 12 | Sun | 2021-11-07 | 16:15 | Crotone | 1.4 | 1–1 | 0.8 | Monza | 2,226 | Stadio Ezio Scida | Marco Di Bello | Match Report | |
| Regular season | 12 | Sun | 2021-11-07 | 20:30 | Cittadella | 1.0 | 2–0 | 0.3 | Pisa | 1,472 | Stadio Pier Cesare Tombolato | Francesco Meraviglia | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 14:00 | Frosinone | 0.8 | 0–0 | 1.2 | Lecce | 7,883 | Stadio Benito Stirpe | Michael Fabbri | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 14:00 | Ternana | 1.6 | 1–1 | 1.7 | Cittadella | 3,350 | Stadio Libero Liberati | Alessandro Prontera | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 14:00 | SPAL | 1.3 | 2–3 | 1.3 | Alessandria | 4,546 | Stadio Paolo Mazza | Matteo Marcenaro | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 14:00 | Pordenone | 0.4 | 0–1 | 1.7 | Ascoli | 994 | Stadio Comunale G.Teghil | Alberto Santoro | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 16:15 | Perugia | 1.2 | 2–0 | 0.8 | Crotone | 3,177 | Stadio Renato Curi | Daniele Minelli | Match Report | |
| Regular season | 13 | Sat | 2021-11-20 | 18:30 | Vicenza Virtus | 2.2 | 2–3 | 1.6 | Brescia | 7,171 | Stadio Romeo Menti | Eugenio Abbattista | Match Report | |
| Regular season | 13 | Sun | 2021-11-21 | 14:00 | US Reggina | 0.7 | 1–2 | 3.8 | Cremonese | 6,335 | Stadio Oreste Granillo | Livio Marinelli | Match Report | |
| Regular season | 13 | Sun | 2021-11-21 | 14:00 | Parma | 0.7 | 1–1 | 1.3 | Cosenza | 6,137 | Stadio Ennio Tardini | Gianpiero Miele | Match Report | |
| Regular season | 13 | Sun | 2021-11-21 | 16:15 | Monza | 1.5 | 3–2 | 1.4 | Como | 6,525 | U-Power Stadium | Marco Serra | Match Report | |
| Regular season | 13 | Sun | 2021-11-21 | 20:30 | Pisa | 0.7 | 1–0 | 1.4 | Benevento | 5,208 | Arena Garibaldi - Stadio Romeo Anconetan... | Maurizio Mariani | Match Report | |
| Regular season | 14 | Fri | 2021-11-26 | 18:00 | Crotone | 0.5 | 0–1 | 1.5 | Vicenza Virtus | 1,856 | Stadio Ezio Scida | Antonio Giua | Match Report | |
| Regular season | 14 | Fri | 2021-11-26 | 20:30 | Lecce | 1.3 | 3–3 | 2.1 | Ternana | 10,314 | Stadio Comunale Via Del Mare | Daniele Paterna | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 14:00 | Alessandria | 1.1 | 1–0 | 1.0 | Cremonese | 2,290 | Stadio Giuseppe Moccagatta | Manuel Volpi | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 14:00 | Ascoli | 2.1 | 1–1 | 1.4 | Monza | 3,948 | Stadio Cino e Lillo Del Duca | Antonio Di Martino | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 14:00 | Benevento | 3.7 | 4–0 | 0.5 | US Reggina | 4,088 | Stadio Ciro Vigorito | Francesco Fourneau | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 14:00 | Frosinone | 2.6 | 2–2 | 2.1 | Pordenone | 4,609 | Stadio Benito Stirpe | Antonio Rapuano | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 14:00 | Cosenza | 0.9 | 0–1 | 0.5 | SPAL | 2,269 | Stadio San Vito | Fabio Maresca | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 16:15 | Brescia | 0.2 | 0–1 | 0.9 | Pisa | 6,211 | Stadio Mario Rigamonti | Simone Sozza | Match Report | |
| Regular season | 14 | Sat | 2021-11-27 | 18:30 | Perugia | 1.1 | 1–1 | 2.2 | Cittadella | 2,544 | Stadio Renato Curi | Alessandro Prontera | Match Report | |
| Regular season | 14 | Sun | 2021-11-28 | 20:30 | Como | 2.1 | 1–1 | 1.7 | Parma | 3,191 | Stadio Giuseppe Sinigaglia | Davide Massa | Match Report | |
| Regular season | 15 | Mon | 2021-11-29 | 20:30 | Ternana | 1.4 | 1–0 | 1.6 | Crotone | 2,077 | Stadio Libero Liberati | Marco Serra | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 18:00 | Cremonese | 2.0 | 1–1 | 0.9 | Frosinone | 2,096 | Stadio Giovanni Zini | Giacomo Camplone | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 18:00 | Pisa | 1.8 | 1–1 | 1.8 | Perugia | 4,127 | Arena Garibaldi - Stadio Romeo Anconetan... | Gianpiero Miele | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 20:30 | Pordenone | 1.5 | 2–0 | 1.0 | Alessandria | 635 | Stadio Comunale G.Teghil | Matteo Marchetti | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 20:30 | US Reggina | 1.5 | 1–2 | 0.8 | Ascoli | 4,229 | Stadio Oreste Granillo | Rosario Abisso | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 20:30 | Monza | 1.0 | 4–1 | 0.6 | Cosenza | 3,450 | U-Power Stadium | Daniele Minelli | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 20:30 | SPAL | 1.1 | 1–3 | 1.3 | Lecce | 4,157 | Stadio Paolo Mazza | Marco Guida | Match Report | |
| Regular season | 15 | Tue | 2021-11-30 | 20:30 | Vicenza Virtus | 1.4 | 2–3 | 1.6 | Benevento | 3,789 | Stadio Romeo Menti | Paolo Valeri | Match Report | |
| Regular season | 15 | Wed | 2021-12-01 | 18:00 | Parma | 0.9 | 0–1 | 1.1 | Brescia | 5,138 | Stadio Ennio Tardini | Cosso Cosso | Match Report | |
| Regular season | 15 | Wed | 2021-12-01 | 20:30 | Cittadella | 1.2 | 2–2 | 2.3 | Como | 1,355 | Stadio Pier Cesare Tombolato | Eugenio Abbattista | Match Report | |
| Regular season | 16 | Fri | 2021-12-03 | 20:30 | Perugia | 0.9 | 1–0 | 1.0 | Vicenza Virtus | 3,114 | Stadio Renato Curi | Gianluca Manganiello | Match Report | |
| Regular season | 16 | Sat | 2021-12-04 | 14:00 | Frosinone | 0.7 | 1–1 | 1.8 | Ternana | 5,409 | Stadio Benito Stirpe | Cosso Cosso | Match Report | |
| Regular season | 16 | Sat | 2021-12-04 | 14:00 | Benevento | 1.9 | 2–1 | 0.8 | Pordenone | 4,168 | Stadio Ciro Vigorito | Antonio Di Martino | Match Report | |
| Regular season | 16 | Sat | 2021-12-04 | 14:00 | Crotone | 1.5 | 1–2 | 1.4 | SPAL | 2,176 | Stadio Ezio Scida | Simone Sozza | Match Report | |
| Regular season | 16 | Sat | 2021-12-04 | 14:00 | Cosenza | 0.6 | 0–2 | 1.7 | Cremonese | 2,728 | Stadio San Vito | Lorenzo Maggioni | Match Report | |
| Regular season | 16 | Sat | 2021-12-04 | 16:15 | Lecce | 1.5 | 2–0 | 0.8 | US Reggina | 9,026 | Stadio Comunale Via Del Mare | Manuel Volpi | Match Report | |
| Regular season | 16 | Sun | 2021-12-05 | 14:00 | Ascoli | 1.1 | 0–0 | 1.0 | Parma | 6,837 | Stadio Cino e Lillo Del Duca | Daniele Minelli | Match Report | |
| Regular season | 16 | Sun | 2021-12-05 | 14:00 | Como | 1.4 | 0–1 | 0.9 | Pisa | 2,471 | Stadio Giuseppe Sinigaglia | Daniele Doveri | Match Report | |
| Regular season | 16 | Sun | 2021-12-05 | 16:15 | Brescia | 1.1 | 0–2 | 1.8 | Monza | 5,080 | Stadio Mario Rigamonti | Luca Pairetto | Match Report | |
| Regular season | 16 | Sun | 2021-12-05 | 20:30 | Alessandria | 1.3 | 0–1 | 1.1 | Cittadella | 1,804 | Stadio Giuseppe Moccagatta | Giovanni Ayroldi | Match Report | |
| Regular season | 17 | Fri | 2021-12-10 | 18:00 | Cremonese | 1.7 | 3–2 | 2.2 | Crotone | 1,495 | Stadio Giovanni Zini | Matteo Marcenaro | Match Report | |
| Regular season | 17 | Fri | 2021-12-10 | 20:30 | Ternana | 1.2 | 0–2 | 2.6 | Benevento | 1,900 | Stadio Libero Liberati | Francesco Meraviglia | Match Report | |
| Regular season | 17 | Sat | 2021-12-11 | 14:00 | Monza | 2.1 | 3–2 | 1.4 | Frosinone | 2,660 | U-Power Stadium | Ivan Pezzuto | Match Report | |
| Regular season | 17 | Sat | 2021-12-11 | 14:00 | SPAL | 0.9 | 0–2 | 2.4 | Brescia | 3,814 | Stadio Paolo Mazza | Piero Giacomelli | Match Report | |
| Regular season | 17 | Sat | 2021-12-11 | 14:00 | Cittadella | 3.3 | 2–0 | 0.3 | Ascoli | 1,429 | Stadio Pier Cesare Tombolato | Andrea Colombo | Match Report | |
| Regular season | 17 | Sat | 2021-12-11 | 14:00 | Pordenone | 1.8 | 1–1 | 0.4 | Cosenza | 847 | Stadio Comunale G.Teghil | Marco Piccinini | Match Report | |
| Regular season | 17 | Sat | 2021-12-11 | 16:15 | Pisa | 0.6 | 1–0 | 1.5 | Lecce | 7,401 | Arena Garibaldi - Stadio Romeo Anconetan... | Daniele Orsato | Match Report | |
| Regular season | 17 | Sun | 2021-12-12 | 14:00 | Parma | 1.5 | 1–1 | 0.5 | Perugia | 4,935 | Stadio Ennio Tardini | Alberto Santoro | Match Report | |
| Regular season | 17 | Sun | 2021-12-12 | 16:15 | Vicenza Virtus | 2.2 | 0–1 | 0.3 | Como | 3,880 | Stadio Romeo Menti | Antonio Rapuano | Match Report | |
| Regular season | 17 | Sun | 2021-12-12 | 20:30 | US Reggina | 0.4 | 0–4 | 2.6 | Alessandria | 3,913 | Stadio Oreste Granillo | Giacomo Camplone | Match Report | |
| Regular season | 18 | Sat | 2021-12-18 | 14:00 | Cosenza | 1.3 | 0–2 | 2.4 | Pisa | 2,079 | Stadio San Vito | Daniele Chiffi | Match Report | |
| Regular season | 18 | Sat | 2021-12-18 | 14:00 | Crotone | 2.0 | 4–1 | 1.2 | Pordenone | 1,529 | Stadio Ezio Scida | Giovanni Ayroldi | Match Report | |
| Regular season | 18 | Sat | 2021-12-18 | 14:00 | Como | 2.3 | 1–1 | 2.5 | US Reggina | 3,098 | Stadio Giuseppe Sinigaglia | Gianpiero Miele | Match Report | |
| Regular season | 18 | Sat | 2021-12-18 | 14:00 | Ascoli | 0.8 | 1–4 | 2.0 | Cremonese | 3,115 | Stadio Cino e Lillo Del Duca | Luca Zufferli | Match Report | |
| Regular season | 18 | Sat | 2021-12-18 | 16:15 | Frosinone | 2.5 | 4–0 | 1.0 | SPAL | 3,208 | Stadio Benito Stirpe | Matteo Marchetti | Match Report | |
| Regular season | 18 | Sun | 2021-12-19 | 14:00 | Alessandria | 0.9 | 0–2 | 2.2 | Parma | 4,097 | Stadio Giuseppe Moccagatta | Gianluca Manganiello | Match Report | |
| Regular season | 18 | Sun | 2021-12-19 | 14:00 | Brescia | 1.0 | 1–1 | 1.1 | Cittadella | 3,275 | Stadio Mario Rigamonti | Daniele Paterna | Match Report | |
| Regular season | 18 | Sun | 2021-12-19 | 16:15 | Perugia | 1.5 | 1–1 | 0.9 | Ternana | 7,556 | Stadio Renato Curi | Marco Guida | Match Report | |
| Regular season | 18 | Thu | 2022-01-13 | 20:30 | Benevento | 2.5 | 3–1 | 1.9 | Monza | 5,502 | Stadio Ciro Vigorito | Paolo Valeri | Match Report | |
| Regular season | 19 | Fri | 2022-01-14 | 20:30 | Ternana | 1.5 | 2–4 | 2.4 | Ascoli | 1,147 | Stadio Libero Liberati | Valerio Marini | Match Report | |
| Regular season | 19 | Sat | 2022-01-15 | 14:00 | Cremonese | 2.5 | 2–0 | 0.9 | Como | 1,580 | Stadio Giovanni Zini | Matteo Gariglio | Match Report | |
| Regular season | 19 | Sat | 2022-01-15 | 14:00 | US Reggina | 0.6 | 0–2 | 1.9 | Brescia | 3,408 | Stadio Oreste Granillo | Alberto Santoro | Match Report | |
| Regular season | 19 | Sat | 2022-01-15 | 16:15 | Pisa | 0.5 | 1–3 | 2.2 | Frosinone | 3,047 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| Regular season | 19 | Sun | 2022-01-16 | 16:15 | Monza | 2.7 | 2–2 | 2.4 | Perugia | 2,493 | U-Power Stadium | Eugenio Abbattista | Match Report | |
| Regular season | 19 | Sun | 2022-01-16 | 16:15 | SPAL | 1.1 | 1–1 | 1.3 | Benevento | 2,546 | Stadio Paolo Mazza | Niccolò Baroni | Match Report | |
| Regular season | 19 | Sun | 2022-01-16 | 16:15 | Pordenone | 0.1 | 0–1 | 1.8 | Lecce | 976 | Stadio Comunale G.Teghil | Andrea Colombo | Match Report | |
| Regular season | 20 | Fri | 2022-01-21 | 20:30 | Parma | 1.1 | 0–1 | 1.3 | Frosinone | 4,056 | Stadio Ennio Tardini | Antonio Di Martino | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | Cosenza | 0.4 | 1–3 | 2.0 | Ascoli | 892 | Stadio San Vito | Francesco Meraviglia | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | SPAL | 0.9 | 0–0 | 1.0 | Pisa | 2,859 | Stadio Paolo Mazza | Giovanni Ayroldi | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | Brescia | 1.3 | 1–1 | 0.7 | Ternana | 3,596 | Stadio Mario Rigamonti | Federico Dionisi | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | Alessandria | 1.2 | 2–0 | 1.0 | Benevento | 1,803 | Stadio Giuseppe Moccagatta | Antonio Rapuano | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | Como | 1.4 | 1–1 | 1.1 | Crotone | 1,540 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 14:00 | Monza | 1.9 | 1–0 | 0.1 | US Reggina | 3,387 | U-Power Stadium | Giacomo Camplone | Match Report | |
| Regular season | 20 | Sat | 2022-01-22 | 16:15 | Perugia | 1.1 | 0–1 | 0.8 | Pordenone | 2,798 | Stadio Renato Curi | Gianpiero Miele | Match Report | |
| Regular season | 20 | Sun | 2022-01-23 | 16:15 | Vicenza Virtus | 2.8 | 3–3 | 2.8 | Cittadella | 4,038 | Stadio Romeo Menti | Valerio Marini | Match Report | |
| Regular season | 20 | Sun | 2022-01-23 | 18:30 | Lecce | 0.8 | 2–1 | 0.5 | Cremonese | 3,080 | Stadio Comunale Via Del Mare | Daniele Chiffi | Match Report | |
| Regular season | 18 | Wed | 2022-01-26 | 20:00 | Lecce | 2.8 | 2–1 | 0.8 | Vicenza Virtus | 6,422 | Stadio Comunale Via Del Mare | Marco Guida | Match Report | |
| Regular season | 19 | Sun | 2022-01-30 | 14:30 | Vicenza Virtus | 1.3 | 2–1 | 0.7 | Alessandria | 4,613 | Stadio Romeo Menti | Davide Ghersini | Match Report | |
| Regular season | 19 | Sun | 2022-01-30 | 14:30 | Cittadella | 1.2 | 1–1 | 1.0 | Cosenza | 1,730 | Stadio Pier Cesare Tombolato | Niccolò Baroni | Match Report | |
| Regular season | 19 | Sun | 2022-01-30 | 14:30 | Parma | 1.2 | 1–1 | 0.8 | Crotone | 4,934 | Stadio Ennio Tardini | Francesco Meraviglia | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Alessandria | 1.3 | 1–1 | 1.8 | Pisa | 2,099 | Stadio Giuseppe Moccagatta | Ivan Pezzuto | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Benevento | 1.5 | 0–0 | 1.2 | Parma | 3,135 | Stadio Ciro Vigorito | Livio Marinelli | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Crotone | 1.1 | 0–0 | 0.5 | Cittadella | 1,809 | Stadio Ezio Scida | Eugenio Abbattista | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Cosenza | 1.1 | 0–0 | 1.4 | Brescia | 1,649 | Stadio San Vito | Gianluca Aureliano | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Como | 2.1 | 1–1 | 2.6 | Lecce | 2,499 | Stadio Giuseppe Sinigaglia | Marco Piccinini | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 14:00 | Ternana | 2.1 | 2–0 | 0.5 | US Reggina | 2,361 | Stadio Libero Liberati | Andrea Colombo | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 16:15 | Frosinone | 3.6 | 2–0 | 1.4 | Vicenza Virtus | 4,337 | Stadio Benito Stirpe | Piero Giacomelli | Match Report | |
| Regular season | 21 | Sat | 2022-02-05 | 18:30 | Ascoli | 0.5 | 0–1 | 0.9 | Perugia | 3,374 | Stadio Cino e Lillo Del Duca | Matteo Marcenaro | Match Report | |
| Regular season | 21 | Sun | 2022-02-06 | 16:15 | Pordenone | 2.1 | 1–1 | 2.1 | SPAL | 1,213 | Stadio Comunale G.Teghil | Alberto Santoro | Match Report | |
| Regular season | 21 | Sun | 2022-02-06 | 16:15 | Cremonese | 1.1 | 3–2 | 1.2 | Monza | 4,062 | Stadio Giovanni Zini | Davide Massa | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 14:00 | Parma | 2.4 | 4–1 | 0.6 | Pordenone | 4,614 | Stadio Ennio Tardini | Giacomo Camplone | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 14:00 | Monza | 2.8 | 4–0 | 0.1 | SPAL | 3,212 | U-Power Stadium | Gianpiero Miele | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 14:00 | Cittadella | 0.6 | 0–2 | 1.2 | Cremonese | 1,526 | Stadio Pier Cesare Tombolato | Daniele Minelli | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 14:00 | Pisa | 1.8 | 0–0 | 0.4 | Ternana | 4,446 | Arena Garibaldi - Stadio Romeo Anconetan... | Davide Ghersini | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 14:00 | Vicenza Virtus | 0.6 | 0–0 | 1.3 | Cosenza | 4,748 | Stadio Romeo Menti | Lorenzo Maggioni | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 16:15 | Perugia | 2.6 | 3–0 | 1.3 | Frosinone | 3,497 | Stadio Renato Curi | Marco Serra | Match Report | |
| Regular season | 22 | Sat | 2022-02-12 | 16:15 | US Reggina | 0.5 | 1–0 | 0.7 | Crotone | 5,882 | Stadio Oreste Granillo | Matteo Gariglio | Match Report | |
| Regular season | 22 | Sun | 2022-02-13 | 15:30 | Lecce | 1.3 | 1–1 | 1.2 | Benevento | 9,580 | Stadio Comunale Via Del Mare | Luca Pairetto | Match Report | |
| Regular season | 22 | Sun | 2022-02-13 | 15:30 | Ascoli | 1.8 | 1–1 | 1.0 | Como | 3,673 | Stadio Cino e Lillo Del Duca | Giovanni Ayroldi | Match Report | |
| Regular season | 22 | Sun | 2022-02-13 | 15:30 | Brescia | 0.8 | 1–1 | 1.2 | Alessandria | 4,151 | Stadio Mario Rigamonti | Daniele Paterna | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | Ternana | 0.9 | 0–1 | 1.9 | Monza | 1,713 | Stadio Libero Liberati | Francesco Meraviglia | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | Cremonese | 1.1 | 3–1 | 2.5 | Parma | 4,847 | Stadio Giovanni Zini | Cosso Cosso | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | Pordenone | 0.9 | 0–1 | 2.0 | Cittadella | 468 | Stadio Comunale G.Teghil | Simone Sozza | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | SPAL | 0.5 | 1–3 | 1.3 | US Reggina | 3,885 | Stadio Paolo Mazza | Niccolò Baroni | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | Cosenza | 1.1 | 1–2 | 2.1 | Perugia | 1,489 | Stadio San Vito | Juan Sacchi | Match Report | |
| Regular season | 23 | Tue | 2022-02-15 | 18:30 | Pisa | 2.9 | 2–2 | 1.3 | Vicenza Virtus | 3,057 | Arena Garibaldi - Stadio Romeo Anconetan... | Antonio Di Martino | Match Report | |
| Regular season | 23 | Wed | 2022-02-16 | 18:30 | Frosinone | 1.8 | 1–2 | 0.4 | Como | 4,293 | Stadio Benito Stirpe | Valerio Marini | Match Report | |
| Regular season | 23 | Wed | 2022-02-16 | 18:30 | Benevento | 0.8 | 0–2 | 1.5 | Ascoli | 1,980 | Stadio Ciro Vigorito | Alberto Santoro | Match Report | |
| Regular season | 23 | Wed | 2022-02-16 | 18:30 | Alessandria | 1.3 | 1–1 | 0.6 | Lecce | 2,109 | Stadio Giuseppe Moccagatta | Gianluca Manganiello | Match Report | |
| Regular season | 23 | Wed | 2022-02-16 | 18:30 | Crotone | 0.2 | 0–1 | 2.0 | Brescia | 1,595 | Stadio Ezio Scida | Manuel Volpi | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 14:00 | US Reggina | 0.9 | 2–0 | 0.7 | Pordenone | 3,685 | Stadio Oreste Granillo | Lorenzo Maggioni | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 14:00 | Vicenza Virtus | 1.0 | 1–1 | 0.6 | SPAL | 4,522 | Stadio Romeo Menti | Gianluca Aureliano | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 14:00 | Monza | 0.9 | 1–2 | 1.2 | Pisa | 4,572 | U-Power Stadium | Fabio Maresca | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 14:00 | Parma | 3.1 | 2–3 | 2.4 | Ternana | 4,629 | Stadio Ennio Tardini | Daniele Minelli | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 14:00 | Ascoli | 1.1 | 3–0 | 0.5 | Alessandria | 3,609 | Stadio Cino e Lillo Del Duca | Gianpiero Miele | Match Report | |
| Regular season | 24 | Sat | 2022-02-19 | 16:15 | Perugia | 0.2 | 0–0 | 0.7 | Cremonese | 4,521 | Stadio Renato Curi | Ivan Pezzuto | Match Report | |
| Regular season | 24 | Sun | 2022-02-20 | 15:30 | Brescia | 1.7 | 2–2 | 1.8 | Frosinone | 3,844 | Stadio Mario Rigamonti | Eugenio Abbattista | Match Report | |
| Regular season | 24 | Sun | 2022-02-20 | 15:30 | Como | 1.9 | 2–1 | 0.2 | Cosenza | 2,680 | Stadio Giuseppe Sinigaglia | Alessandro Prontera | Match Report | |
| Regular season | 24 | Sun | 2022-02-20 | 15:30 | Cittadella | 0.5 | 0–1 | 1.1 | Benevento | 1,565 | Stadio Pier Cesare Tombolato | Matteo Gariglio | Match Report | |
| Regular season | 24 | Sun | 2022-02-20 | 15:30 | Lecce | 3.8 | 3–0 | 0.4 | Crotone | 8,196 | Stadio Comunale Via Del Mare | Davide Ghersini | Match Report | |
| Regular season | 25 | Tue | 2022-02-22 | 18:30 | Pordenone | 1.3 | 1–4 | 2.8 | Monza | 618 | Stadio Comunale G.Teghil | Marco Serra | Match Report | |
| Regular season | 25 | Tue | 2022-02-22 | 18:30 | Cremonese | 2.1 | 0–0 | 1.4 | Vicenza Virtus | 3,207 | Stadio Giovanni Zini | Andrea Colombo | Match Report | |
| Regular season | 25 | Tue | 2022-02-22 | 18:30 | Alessandria | 1.2 | 1–2 | 1.3 | Perugia | 1,745 | Stadio Giuseppe Moccagatta | Marco Piccinini | Match Report | |
| Regular season | 25 | Tue | 2022-02-22 | 18:30 | Pisa | 0.8 | 0–0 | 1.3 | Parma | 5,560 | Arena Garibaldi - Stadio Romeo Anconetan... | Rosario Abisso | Match Report | |
| Regular season | 25 | Tue | 2022-02-22 | 18:30 | SPAL | 2.2 | 5–1 | 1.8 | Ternana | 3,474 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| Regular season | 25 | Wed | 2022-02-23 | 18:30 | Frosinone | 1.6 | 3–0 | 0.0 | US Reggina | 4,004 | Stadio Benito Stirpe | Francesco Meraviglia | Match Report | |
| Regular season | 25 | Wed | 2022-02-23 | 18:30 | Crotone | 2.9 | 3–3 | 2.5 | Cosenza | 3,704 | Stadio Ezio Scida | Davide Massa | Match Report | |
| Regular season | 25 | Wed | 2022-02-23 | 18:30 | Benevento | 2.8 | 5–0 | 0.2 | Como | 2,195 | Stadio Ciro Vigorito | Valerio Marini | Match Report | |
| Regular season | 25 | Wed | 2022-02-23 | 18:30 | Brescia | 1.7 | 2–0 | 0.8 | Ascoli | 3,051 | Stadio Mario Rigamonti | Antonio Di Martino | Match Report | |
| Regular season | 25 | Wed | 2022-02-23 | 18:30 | Lecce | 2.0 | 1–2 | 0.5 | Cittadella | 6,235 | Stadio Comunale Via Del Mare | Giacomo Camplone | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 14:00 | Como | 0.6 | 1–1 | 1.4 | Brescia | 2,588 | Stadio Giuseppe Sinigaglia | Massimiliano Irrati | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 14:00 | Cosenza | 1.1 | 2–1 | 0.4 | Alessandria | 3,051 | Stadio San Vito | Maurizio Mariani | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 14:00 | Parma | 1.4 | 4–0 | 1.3 | SPAL | 5,286 | Stadio Ennio Tardini | Valerio Marini | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 14:00 | Ternana | 0.5 | 1–2 | 1.4 | Cremonese | 2,022 | Stadio Libero Liberati | Antonio Giua | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 14:00 | Vicenza Virtus | 0.6 | 1–0 | 0.6 | Pordenone | 5,125 | Stadio Romeo Menti | Gianluca Manganiello | Match Report | |
| Regular season | 26 | Sat | 2022-02-26 | 16:15 | Perugia | 1.1 | 0–1 | 1.1 | Benevento | 4,130 | Stadio Renato Curi | Eugenio Abbattista | Match Report | |
| Regular season | 26 | Sun | 2022-02-27 | 15:30 | Cittadella | 1.2 | 3–0 | 0.6 | Frosinone | 1,294 | Stadio Pier Cesare Tombolato | Alberto Santoro | Match Report | |
| Regular season | 26 | Sun | 2022-02-27 | 15:30 | Ascoli | 1.6 | 2–1 | 0.8 | Crotone | 2,720 | Stadio Cino e Lillo Del Duca | Niccolò Baroni | Match Report | |
| Regular season | 26 | Sun | 2022-02-27 | 15:30 | Monza | 1.0 | 0–1 | 1.2 | Lecce | 6,858 | U-Power Stadium | Daniele Doveri | Match Report | |
| Regular season | 26 | Sun | 2022-02-27 | 15:30 | US Reggina | 0.7 | 1–0 | 1.4 | Pisa | 3,597 | Stadio Oreste Granillo | Luca Massimi | Match Report | |
| Regular season | 27 | Tue | 2022-03-01 | 18:30 | Ternana | 0.5 | 1–0 | 1.0 | Pordenone | 1,163 | Stadio Libero Liberati | Davide Ghersini | Match Report | |
| Regular season | 27 | Tue | 2022-03-01 | 18:30 | Benevento | 0.7 | 1–1 | 2.1 | Cremonese | 3,099 | Stadio Ciro Vigorito | Daniele Minelli | Match Report | |
| Regular season | 27 | Tue | 2022-03-01 | 18:30 | Brescia | 2.8 | 2–1 | 0.6 | Perugia | 2,924 | Stadio Mario Rigamonti | Gianpiero Miele | Match Report | |
| Regular season | 27 | Tue | 2022-03-01 | 20:30 | Alessandria | 2.7 | 1–1 | 1.1 | Como | 1,857 | Stadio Giuseppe Moccagatta | Francesco Meraviglia | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | Monza | 1.5 | 1–1 | 0.2 | Parma | 3,789 | U-Power Stadium | Paolo Valeri | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | Frosinone | 1.7 | 1–0 | 0.4 | Cosenza | 4,115 | Stadio Benito Stirpe | Lorenzo Maggioni | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | US Reggina | 1.6 | 3–1 | 2.0 | Vicenza Virtus | 3,401 | Stadio Oreste Granillo | Antonio Di Martino | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | Pisa | 2.7 | 3–2 | 0.6 | Crotone | 3,623 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | SPAL | 1.0 | 0–0 | 0.5 | Cittadella | 4,132 | Stadio Paolo Mazza | Ivan Pezzuto | Match Report | |
| Regular season | 27 | Wed | 2022-03-02 | 18:30 | Lecce | 2.8 | 3–1 | 0.9 | Ascoli | 5,359 | Stadio Comunale Via Del Mare | Rosario Abisso | Match Report | |
| Regular season | 28 | Sat | 2022-03-05 | 14:00 | Como | 0.4 | 0–2 | 2.7 | SPAL | 2,317 | Stadio Giuseppe Sinigaglia | Matteo Gariglio | Match Report | |
| Regular season | 28 | Sat | 2022-03-05 | 14:00 | Parma | 1.1 | 1–1 | 0.4 | US Reggina | 6,125 | Stadio Ennio Tardini | Eugenio Abbattista | Match Report | |
| Regular season | 28 | Sat | 2022-03-05 | 14:00 | Pordenone | 0.6 | 0–1 | 1.2 | Pisa | 717 | Stadio Comunale G.Teghil | Matteo Marcenaro | Match Report | |
| Regular season | 28 | Sat | 2022-03-05 | 14:00 | Cittadella | 1.8 | 1–2 | 1.3 | Monza | 1,657 | Stadio Pier Cesare Tombolato | Marco Piccinini | Match Report | |
| Regular season | 28 | Sat | 2022-03-05 | 16:15 | Cremonese | 1.1 | 2–1 | 0.4 | Brescia | 9,098 | Stadio Giovanni Zini | Giovanni Ayroldi | Match Report | |
| Regular season | 28 | Sun | 2022-03-06 | 15:30 | Perugia | 0.9 | 1–1 | 2.1 | Lecce | 4,663 | Stadio Renato Curi | Alberto Santoro | Match Report | |
| Regular season | 28 | Sun | 2022-03-06 | 15:30 | Vicenza Virtus | 1.9 | 3–1 | 1.1 | Ternana | 5,062 | Stadio Romeo Menti | Juan Sacchi | Match Report | |
| Regular season | 28 | Sun | 2022-03-06 | 15:30 | Crotone | 1.4 | 0–0 | 0.4 | Alessandria | 1,918 | Stadio Ezio Scida | Valerio Marini | Match Report | |
| Regular season | 28 | Sun | 2022-03-06 | 15:30 | Ascoli | 0.9 | 1–1 | 0.8 | Frosinone | 3,901 | Stadio Cino e Lillo Del Duca | Marco Serra | Match Report | |
| Regular season | 29 | Fri | 2022-03-11 | 20:30 | Parma | 2.0 | 1–1 | 0.9 | Cittadella | 4,733 | Stadio Ennio Tardini | Matteo Marchetti | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 14:00 | Lecce | 1.0 | 1–1 | 1.3 | Brescia | 12,316 | Stadio Comunale Via Del Mare | Michael Fabbri | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 14:00 | Ternana | 0.9 | 2–0 | 1.5 | Cosenza | 2,698 | Stadio Libero Liberati | Niccolò Baroni | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 14:00 | US Reggina | 0.9 | 0–1 | 0.7 | Perugia | 3,956 | Stadio Oreste Granillo | Antonio Rapuano | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 16:15 | Frosinone | 2.0 | 3–0 | 1.1 | Alessandria | 4,205 | Stadio Benito Stirpe | Andrea Colombo | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 16:15 | SPAL | 0.4 | 1–2 | 1.3 | Ascoli | 4,688 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 16:15 | Pordenone | 1.4 | 1–1 | 1.6 | Como | 678 | Stadio Comunale G.Teghil | Gianpiero Miele | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 16:15 | Benevento | 2.2 | 3–1 | 0.4 | Crotone | 2,936 | Stadio Ciro Vigorito | Antonio Giua | Match Report | |
| Regular season | 29 | Sat | 2022-03-12 | 16:15 | Monza | 3.0 | 4–0 | 0.2 | Vicenza Virtus | 3,524 | U-Power Stadium | Daniele Minelli | Match Report | |
| Regular season | 29 | Sun | 2022-03-13 | 15:30 | Pisa | 2.5 | 3–0 | 1.7 | Cremonese | 7,374 | Arena Garibaldi - Stadio Romeo Anconetan... | Alessandro Prontera | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Vicenza Virtus | 0.9 | 0–1 | 1.3 | Parma | 5,859 | Stadio Romeo Menti | Ivan Pezzuto | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Cittadella | 0.9 | 0–0 | 0.5 | US Reggina | 1,105 | Stadio Pier Cesare Tombolato | Lorenzo Maggioni | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Crotone | 1.8 | 2–0 | 1.1 | Frosinone | 1,311 | Stadio Ezio Scida | Matteo Gariglio | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Brescia | 2.0 | 2–2 | 0.5 | Benevento | 3,729 | Stadio Mario Rigamonti | Marco Piccinini | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Cosenza | 1.0 | 2–2 | 1.9 | Lecce | 2,477 | Stadio San Vito | Livio Marinelli | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 18:30 | Como | 0.6 | 1–1 | 2.2 | Ternana | 1,476 | Stadio Giuseppe Sinigaglia | Cosso Cosso | Match Report | |
| Regular season | 30 | Tue | 2022-03-15 | 20:30 | Alessandria | 0.2 | 0–3 | 1.0 | Monza | 2,050 | Stadio Giuseppe Moccagatta | Giacomo Camplone | Match Report | |
| Regular season | 30 | Wed | 2022-03-16 | 18:30 | Ascoli | 1.6 | 2–0 | 0.7 | Pisa | 4,027 | Stadio Cino e Lillo Del Duca | Valerio Marini | Match Report | |
| Regular season | 30 | Wed | 2022-03-16 | 18:30 | Perugia | 1.3 | 1–1 | 0.4 | SPAL | 3,009 | Stadio Renato Curi | Antonio Di Martino | Match Report | |
| Regular season | 30 | Wed | 2022-03-16 | 18:30 | Cremonese | 0.9 | 2–1 | 0.8 | Pordenone | 3,474 | Stadio Giovanni Zini | Francesco Meraviglia | Match Report | |
| Regular season | 31 | Sat | 2022-03-19 | 14:00 | US Reggina | 1.2 | 1–0 | 1.2 | Cosenza | 4,932 | Stadio Oreste Granillo | Antonio Giua | Match Report | |
| Regular season | 31 | Sat | 2022-03-19 | 14:00 | Parma | 0.8 | 0–0 | 1.0 | Lecce | 7,916 | Stadio Ennio Tardini | Antonio Rapuano | Match Report | |
| Regular season | 31 | Sat | 2022-03-19 | 14:00 | Monza | 1.0 | 1–0 | 0.6 | Crotone | 3,601 | U-Power Stadium | Daniele Paterna | Match Report | |
| Regular season | 31 | Sat | 2022-03-19 | 14:00 | Ternana | 1.1 | 3–0 | 0.6 | Alessandria | 2,538 | Stadio Libero Liberati | Eugenio Abbattista | Match Report | |
| Regular season | 31 | Sat | 2022-03-19 | 16:15 | Frosinone | 1.6 | 2–0 | 0.5 | Benevento | 5,372 | Stadio Benito Stirpe | Davide Ghersini | Match Report | |
| Regular season | 31 | Sun | 2022-03-20 | 14:00 | Pisa | 0.9 | 1–0 | 0.3 | Cittadella | 5,441 | Arena Garibaldi - Stadio Romeo Anconetan... | Gianluca Aureliano | Match Report | |
| Regular season | 31 | Sun | 2022-03-20 | 14:00 | Perugia | 1.3 | 0–1 | 0.5 | Como | 3,406 | Stadio Renato Curi | Marco Serra | Match Report | |
| Regular season | 31 | Sun | 2022-03-20 | 14:00 | Vicenza Virtus | 1.7 | 2–0 | 0.6 | Ascoli | 5,041 | Stadio Romeo Menti | Alberto Santoro | Match Report | |
| Regular season | 31 | Sun | 2022-03-20 | 16:15 | Pordenone | 1.6 | 1–1 | 1.5 | Brescia | 1,008 | Stadio Comunale G.Teghil | Niccolò Baroni | Match Report | |
| Regular season | 31 | Sun | 2022-03-20 | 16:15 | SPAL | 1.1 | 0–2 | 1.5 | Cremonese | 4,961 | Stadio Paolo Mazza | Luca Pairetto | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Lecce | 0.9 | 1–0 | 0.1 | Frosinone | 9,327 | Stadio Comunale Via Del Mare | Marco Guida | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Ascoli | 0.9 | 1–0 | 0.2 | Pordenone | 3,564 | Stadio Cino e Lillo Del Duca | Cosso Cosso | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Cittadella | 0.7 | 1–2 | 1.4 | Ternana | 1,185 | Stadio Pier Cesare Tombolato | Gianpiero Miele | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Cosenza | 2.3 | 1–3 | 0.7 | Parma | 2,252 | Stadio San Vito | Valerio Marini | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Cremonese | 0.9 | 1–1 | 1.6 | US Reggina | 7,255 | Stadio Giovanni Zini | Eugenio Abbattista | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 14:00 | Alessandria | 1.7 | 2–2 | 1.6 | SPAL | 3,198 | Stadio Giuseppe Moccagatta | Simone Sozza | Match Report | |
| Regular season | 32 | Sat | 2022-04-02 | 16:15 | Benevento | 2.0 | 5–1 | 1.2 | Pisa | 3,409 | Stadio Ciro Vigorito | Antonio Di Martino | Match Report | |
| Regular season | 32 | Sun | 2022-04-03 | 15:30 | Como | 0.6 | 2–0 | 1.2 | Monza | 4,904 | Stadio Giuseppe Sinigaglia | Alessandro Prontera | Match Report | |
| Regular season | 32 | Sun | 2022-04-03 | 15:30 | Brescia | 2.5 | 2–0 | 0.4 | Vicenza Virtus | 5,439 | Stadio Mario Rigamonti | Matteo Gariglio | Match Report | |
| Regular season | 32 | Sun | 2022-04-03 | 15:30 | Crotone | 1.6 | 1–1 | 1.1 | Perugia | 1,877 | Stadio Ezio Scida | Giacomo Camplone | Match Report | |
| Regular season | 33 | Tue | 2022-04-05 | 19:00 | US Reggina | 0.6 | 0–3 | 1.4 | Benevento | 4,237 | Stadio Oreste Granillo | Andrea Colombo | Match Report | |
| Regular season | 33 | Tue | 2022-04-05 | 19:00 | Pordenone | 2.0 | 2–0 | 1.5 | Frosinone | 456 | Stadio Comunale G.Teghil | Marco Serra | Match Report | |
| Regular season | 33 | Tue | 2022-04-05 | 19:00 | SPAL | 1.5 | 2–2 | 1.3 | Cosenza | 4,338 | Stadio Paolo Mazza | Daniele Minelli | Match Report | |
| Regular season | 33 | Tue | 2022-04-05 | 19:00 | Cremonese | 1.8 | 2–1 | 0.9 | Alessandria | 6,311 | Stadio Giovanni Zini | Ivan Pezzuto | Match Report | |
| Regular season | 33 | Tue | 2022-04-05 | 19:00 | Ternana | 1.0 | 1–4 | 0.9 | Lecce | 3,827 | Stadio Libero Liberati | Matteo Marcenaro | Match Report | |
| Regular season | 33 | Wed | 2022-04-06 | 14:00 | Parma | 1.4 | 4–3 | 2.3 | Como | 5,310 | Stadio Ennio Tardini | Francesco Meraviglia | Match Report | |
| Regular season | 33 | Wed | 2022-04-06 | 19:00 | Vicenza Virtus | 1.5 | 1–1 | 0.6 | Crotone | 5,259 | Stadio Romeo Menti | Niccolò Baroni | Match Report | |
| Regular season | 33 | Wed | 2022-04-06 | 19:00 | Cittadella | 1.1 | 0–0 | 0.6 | Perugia | 1,191 | Stadio Pier Cesare Tombolato | Ivan Robilotta | Match Report | |
| Regular season | 33 | Wed | 2022-04-06 | 19:00 | Pisa | 0.5 | 0–0 | 1.2 | Brescia | 7,271 | Arena Garibaldi - Stadio Romeo Anconetan... | Alberto Santoro | Match Report | |
| Regular season | 33 | Wed | 2022-04-06 | 19:00 | Monza | 1.5 | 2–0 | 1.2 | Ascoli | 4,633 | U-Power Stadium | Matteo Gariglio | Match Report | |
| Regular season | 34 | Sat | 2022-04-09 | 14:00 | Como | 0.7 | 1–2 | 0.9 | Cittadella | 1,999 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| Regular season | 34 | Sat | 2022-04-09 | 14:00 | Alessandria | 1.2 | 2–0 | 0.3 | Pordenone | 2,330 | Stadio Giuseppe Moccagatta | Valerio Marini | Match Report | |
| Regular season | 34 | Sat | 2022-04-09 | 14:00 | Lecce | 1.8 | 1–0 | 0.9 | SPAL | 11,578 | Stadio Comunale Via Del Mare | Matteo Marchetti | Match Report | |
| Regular season | 34 | Sat | 2022-04-09 | 16:15 | Frosinone | 1.8 | 2–1 | 1.1 | Cremonese | 5,067 | Stadio Benito Stirpe | Rosario Abisso | Match Report | |
| Regular season | 34 | Sun | 2022-04-10 | 14:30 | Benevento | 1.0 | 1–0 | 0.2 | Vicenza Virtus | 3,214 | Stadio Ciro Vigorito | Lorenzo Maggioni | Match Report | |
| Regular season | 34 | Sun | 2022-04-10 | 15:30 | Crotone | 0.7 | 1–2 | 1.0 | Ternana | 2,024 | Stadio Ezio Scida | Eugenio Abbattista | Match Report | |
| Regular season | 34 | Sun | 2022-04-10 | 15:30 | Ascoli | 1.8 | 2–0 | 0.2 | US Reggina | 4,891 | Stadio Cino e Lillo Del Duca | Antonio Di Martino | Match Report | |
| Regular season | 34 | Sun | 2022-04-10 | 15:30 | Cosenza | 0.6 | 0–2 | 2.5 | Monza | 2,592 | Stadio San Vito | Fabio Maresca | Match Report | |
| Regular season | 34 | Sun | 2022-04-10 | 18:00 | Perugia | 2.6 | 1–1 | 1.2 | Pisa | 5,042 | Stadio Renato Curi | Davide Massa | Match Report | |
| Regular season | 34 | Mon | 2022-04-11 | 20:30 | Brescia | 0.7 | 1–0 | 0.8 | Parma | 6,715 | Stadio Mario Rigamonti | Davide Ghersini | Match Report | |
| Regular season | 28 | Thu | 2022-04-14 | 20:00 | Cosenza | 0.5 | 1–0 | 1.8 | Benevento | 3,001 | Stadio San Vito | Antonio Rapuano | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 12:30 | SPAL | 1.4 | 1–1 | 1.6 | Crotone | 4,110 | Stadio Paolo Mazza | Massimiliano Irrati | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 15:00 | Cremonese | 1.0 | 3–1 | 1.5 | Cosenza | 6,287 | Stadio Giovanni Zini | Francesco Meraviglia | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 15:00 | Pordenone | 0.6 | 1–4 | 2.6 | Benevento | 718 | Stadio Comunale G.Teghil | Giacomo Camplone | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 15:00 | Vicenza Virtus | 1.1 | 1–2 | 0.2 | Perugia | 5,307 | Stadio Romeo Menti | Giovanni Ayroldi | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 15:00 | US Reggina | 1.4 | 1–0 | 0.9 | Lecce | 3,682 | Stadio Oreste Granillo | Francesco Fourneau | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 18:00 | Pisa | 2.3 | 3–1 | 1.3 | Como | 6,218 | Arena Garibaldi - Stadio Romeo Anconetan... | Ivan Pezzuto | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 18:00 | Cittadella | 1.1 | 1–2 | 1.6 | Alessandria | 1,497 | Stadio Pier Cesare Tombolato | Antonio Giua | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 18:00 | Ternana | 1.0 | 4–4 | 2.2 | Frosinone | 3,605 | Stadio Libero Liberati | Ivan Robilotta | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 18:00 | Parma | 1.4 | 0–1 | 0.7 | Ascoli | 7,309 | Stadio Ennio Tardini | Matteo Marcenaro | Match Report | |
| Regular season | 35 | Mon | 2022-04-18 | 20:30 | Monza | 1.0 | 1–1 | 1.8 | Brescia | 7,504 | U-Power Stadium | Livio Marinelli | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 12:30 | Ascoli | 1.3 | 0–0 | 0.8 | Cittadella | 6,164 | Stadio Cino e Lillo Del Duca | Daniele Minelli | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 15:00 | Alessandria | 0.9 | 0–0 | 0.3 | US Reggina | 4,783 | Stadio Giuseppe Moccagatta | Matteo Gariglio | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 15:00 | Crotone | 0.9 | 3–1 | 1.1 | Cremonese | 1,546 | Stadio Ezio Scida | Michael Fabbri | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 15:00 | Lecce | 2.1 | 2–0 | 0.3 | Pisa | 23,933 | Stadio Comunale Via Del Mare | Luca Pairetto | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 15:00 | Frosinone | 1.0 | 4–1 | 0.7 | Monza | 6,631 | Stadio Benito Stirpe | Daniele Chiffi | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 15:00 | Cosenza | 2.2 | 3–1 | 1.5 | Pordenone | 5,824 | Stadio San Vito | Luca Massimi | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 18:00 | Como | 1.5 | 0–2 | 1.5 | Vicenza Virtus | 2,491 | Stadio Giuseppe Sinigaglia | Marco Serra | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 18:00 | Benevento | 1.7 | 1–2 | 2.4 | Ternana | 6,823 | Stadio Ciro Vigorito | Niccolò Baroni | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 18:00 | Brescia | 1.2 | 1–1 | 0.9 | SPAL | 8,710 | Stadio Mario Rigamonti | Antonio Rapuano | Match Report | |
| Regular season | 36 | Mon | 2022-04-25 | 20:30 | Perugia | 3.1 | 2–1 | 1.4 | Parma | 4,750 | Stadio Renato Curi | Antonio Di Martino | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Pordenone | 2.3 | 3–3 | 3.1 | Crotone | 615 | Stadio Comunale G.Teghil | Gianpiero Miele | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Pisa | 1.0 | 1–1 | 1.3 | Cosenza | 7,674 | Arena Garibaldi - Stadio Romeo Anconetan... | Eugenio Abbattista | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Monza | 2.5 | 3–0 | 0.5 | Benevento | 8,402 | U-Power Stadium | Marco Di Bello | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Ternana | 2.3 | 1–0 | 0.9 | Perugia | 10,354 | Stadio Libero Liberati | Davide Massa | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Cremonese | 0.5 | 0–1 | 0.7 | Ascoli | 12,119 | Stadio Giovanni Zini | Gianluca Manganiello | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | SPAL | 0.8 | 3–0 | 0.9 | Frosinone | 7,033 | Stadio Paolo Mazza | Gianluca Aureliano | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Vicenza Virtus | 1.2 | 2–1 | 0.8 | Lecce | 10,019 | Stadio Romeo Menti | Maurizio Mariani | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Cittadella | 0.6 | 1–0 | 1.0 | Brescia | 2,454 | Stadio Pier Cesare Tombolato | Valerio Marini | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 14:00 | Parma | 0.8 | 2–2 | 0.8 | Alessandria | 6,566 | Stadio Ennio Tardini | Daniele Paterna | Match Report | |
| Regular season | 37 | Sat | 2022-04-30 | 16:15 | US Reggina | 0.8 | 1–4 | 1.9 | Como | 3,832 | Stadio Oreste Granillo | Ivan Robilotta | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 18:15 | Crotone | 0.7 | 0–1 | 0.7 | Parma | 1,362 | Stadio Ezio Scida | Andrea Colombo | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Perugia | 1.9 | 1–0 | 1.7 | Monza | 6,828 | Stadio Renato Curi | Michael Fabbri | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Frosinone | 0.8 | 1–2 | 0.6 | Pisa | 8,927 | Stadio Benito Stirpe | Antonio Rapuano | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Como | 1.4 | 1–2 | 2.0 | Cremonese | 11,454 | Stadio Giuseppe Sinigaglia | Gianluca Aureliano | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Benevento | 1.9 | 1–2 | 2.4 | SPAL | 5,155 | Stadio Ciro Vigorito | Antonio Giua | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Cosenza | 0.4 | 1–0 | 0.3 | Cittadella | 11,454 | Stadio San Vito | Davide Ghersini | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Brescia | 2.6 | 3–0 | 0.4 | US Reggina | 3,742 | Stadio Mario Rigamonti | Matteo Marchetti | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Lecce | 3.1 | 1–0 | 0.1 | Pordenone | 26,904 | Stadio Comunale Via Del Mare | Marco Piccinini | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Ascoli | 2.5 | 4–1 | 0.9 | Ternana | 7,651 | Stadio Cino e Lillo Del Duca | Lorenzo Maggioni | Match Report | |
| Regular season | 38 | Fri | 2022-05-06 | 20:30 | Alessandria | 0.6 | 0–1 | 0.6 | Vicenza Virtus | 4,838 | Stadio Giuseppe Moccagatta | Daniele Chiffi | Match Report | |
| Relegation play-out | Thu | 2022-05-12 | 20:30 | Vicenza Virtus | 2.3 | 1–0 | 0.6 | Cosenza | 10,659 | Stadio Romeo Menti | Fabio Maresca | Match Report | Leg 1 of 2 | |
| Preliminary round | Fri | 2022-05-13 | 20:30 | Ascoli | 0.9 | 0–1 | 0.4 | Benevento | 10,797 | Stadio Cino e Lillo Del Duca | Gianluca Manganiello | Match Report | ||
| Preliminary round | Sat | 2022-05-14 | 18:00 | Brescia | 2.7 | 3–2 | 1.0 | Perugia | 10,740 | Stadio Mario Rigamonti | Francesco Fourneau | Match Report | Required Extra Time | |
| Semi-finals | Tue | 2022-05-17 | 20:30 | Benevento | 1.7 | 1–0 | 0.7 | Pisa | 10,979 | Stadio Ciro Vigorito | Alessandro Prontera | Match Report | Leg 1 of 2 | |
| Semi-finals | Wed | 2022-05-18 | 20:00 | Brescia | 1.3 | 1–2 | 2.5 | Monza | 13,600 | Stadio Mario Rigamonti | Gianluca Aureliano | Match Report | Leg 1 of 2 | |
| Relegation play-out | Fri | 2022-05-20 | 20:30 | Cosenza | 1.7 | 2–0 | 0.7 | Vicenza Virtus | 17,771 | Stadio San Vito | Davide Massa | Match Report | Leg 2 of 2; Cosenza won | |
| Semi-finals | Sat | 2022-05-21 | 18:00 | Pisa | 1.0 | 1–0 | 0.2 | Benevento | 9,942 | Arena Garibaldi - Stadio Romeo Anconetan... | Simone Sozza | Match Report | Leg 2 of 2; Pisa won | |
| Semi-finals | Sun | 2022-05-22 | 21:00 | Monza | 1.6 | 2–1 | 1.0 | Brescia | 8,559 | U-Power Stadium | Paolo Valeri | Match Report | Leg 2 of 2; Monza won | |
| Finals | Thu | 2022-05-26 | 20:30 | Monza | 1.6 | 2–1 | 1.6 | Pisa | 9,649 | U-Power Stadium | Marco Guida | Match Report | Leg 1 of 2 | |
| Finals | Sun | 2022-05-29 | 20:30 | Pisa | 1.4 | 3–4 | 2.4 | Monza | 9,500 | Arena Garibaldi - Stadio Romeo Anconetan... | Maurizio Mariani | Match Report | Leg 2 of 2; Monza won |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-20 | 20:30 | Frosinone | 2.0 | 2–2 | 1.4 | Parma | 5,094 | Stadio Benito Stirpe | Massimiliano Irrati | Match Report | |
| 1 | Sat | 2021-08-21 | 18:00 | Pordenone | 0.7 | 0–1 | 0.9 | Perugia | 955 | Stadio Comunale G.Teghil | Luca Massimi | Match Report | |
| 1 | Sat | 2021-08-21 | 20:30 | Cittadella | 1.9 | 1–0 | 0.5 | Vicenza Virtus | 1,788 | Stadio Pier Cesare Tombolato | Matteo Marcenaro | Match Report | |
| 1 | Sun | 2021-08-22 | 18:00 | US Reggina | 0.9 | 0–0 | 0.4 | Monza | 5,825 | Stadio Oreste Granillo | Antonio Giua | Match Report | |
| 1 | Sun | 2021-08-22 | 18:00 | Ternana | 1.5 | 0–2 | 2.2 | Brescia | 3,359 | Stadio Libero Liberati | Gianpiero Miele | Match Report | |
| 1 | Sun | 2021-08-22 | 20:30 | Pisa | 0.8 | 1–0 | 1.5 | SPAL | 2,933 | Arena Garibaldi - Stadio Romeo Anconetan... | Giacomo Camplone | Match Report | |
| 1 | Sun | 2021-08-22 | 20:30 | Benevento | 2.1 | 4–3 | 2.2 | Alessandria | 2,869 | Stadio Ciro Vigorito | Marco Di Bello | Match Report | |
| 1 | Sun | 2021-08-22 | 20:30 | Cremonese | 2.3 | 3–0 | 1.5 | Lecce | 2,372 | Stadio Giovanni Zini | Niccolò Baroni | Match Report | |
| 1 | Sun | 2021-08-22 | 20:30 | Crotone | 1.6 | 2–2 | 2.5 | Como | 2,500 | Stadio Ezio Scida | Daniele Doveri | Match Report | |
| 1 | Sun | 2021-08-22 | 20:30 | Ascoli | 1.1 | 1–0 | 0.4 | Cosenza | 3,852 | Stadio Cino e Lillo Del Duca | Lorenzo Maggioni | Match Report | |
| 2 | Fri | 2021-08-27 | 18:00 | Pisa | 2.2 | 2–0 | 0.3 | Alessandria | 3,882 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| 2 | Fri | 2021-08-27 | 20:30 | Brescia | 2.7 | 5–1 | 0.9 | Cosenza | 4,000 | Stadio Mario Rigamonti | Francesco Meraviglia | Match Report | |
| 2 | Sat | 2021-08-28 | 18:00 | Vicenza Virtus | 0.5 | 0–2 | 2.1 | Frosinone | 2,844 | Stadio Romeo Menti | Daniele Minelli | Match Report | |
| 2 | Sat | 2021-08-28 | 20:30 | Perugia | 1.9 | 2–3 | 2.0 | Ascoli | 3,400 | Stadio Renato Curi | Paolo Valeri | Match Report | |
| 2 | Sun | 2021-08-29 | 18:00 | Cittadella | 2.5 | 4–2 | 1.3 | Crotone | 1,200 | Stadio Pier Cesare Tombolato | Luca Zufferli | Match Report | |
| 2 | Sun | 2021-08-29 | 20:30 | Monza | 1.4 | 1–0 | 0.6 | Cremonese | 2,501 | U-Power Stadium | Marco Piccinini | Match Report | |
| 2 | Sun | 2021-08-29 | 20:30 | Parma | 1.2 | 1–0 | 1.7 | Benevento | 3,550 | Stadio Ennio Tardini | Andrea Colombo | Match Report | |
| 2 | Sun | 2021-08-29 | 20:30 | SPAL | 3.1 | 5–0 | 0.3 | Pordenone | 2,537 | Stadio Paolo Mazza | Giovanni Ayroldi | Match Report | |
| 2 | Sun | 2021-08-29 | 20:30 | US Reggina | 3.0 | 3–2 | 1.7 | Ternana | 5,005 | Stadio Oreste Granillo | Antonio Di Martino | Match Report | |
| 2 | Sun | 2021-08-29 | 20:30 | Lecce | 1.3 | 1–1 | 1.1 | Como | 6,192 | Stadio Comunale Via Del Mare | Matteo Marchetti | Match Report | |
| 3 | Fri | 2021-09-10 | 20:30 | Benevento | 1.3 | 0–0 | 1.7 | Lecce | 5,120 | Stadio Ciro Vigorito | Alberto Santoro | Match Report | |
| 3 | Sat | 2021-09-11 | 14:00 | SPAL | 1.2 | 1–1 | 1.3 | Monza | 3,726 | Stadio Paolo Mazza | Luca Massimi | Match Report | |
| 3 | Sat | 2021-09-11 | 14:00 | Frosinone | 0.6 | 0–0 | 0.6 | Perugia | 5,594 | Stadio Benito Stirpe | Matteo Gariglio | Match Report | |
| 3 | Sat | 2021-09-11 | 14:00 | Como | 1.5 | 0–1 | 1.5 | Ascoli | 2,297 | Stadio Giuseppe Sinigaglia | Antonio Giua | Match Report | |
| 3 | Sat | 2021-09-11 | 14:00 | Alessandria | 1.7 | 1–3 | 1.5 | Brescia | 1,491 | Stadio Giuseppe Moccagatta | Francesco Fourneau | Match Report | |
| 3 | Sat | 2021-09-11 | 16:15 | Ternana | 1.5 | 1–4 | 1.0 | Pisa | 4,003 | Stadio Libero Liberati | Fabio Maresca | Match Report | |
| 3 | Sat | 2021-09-11 | 18:30 | Crotone | 0.8 | 1–1 | 0.6 | US Reggina | 2,220 | Stadio Ezio Scida | Michael Fabbri | Match Report | |
| 3 | Sun | 2021-09-12 | 14:00 | Cosenza | 0.9 | 2–1 | 1.1 | Vicenza Virtus | 3,026 | Stadio San Vito | Alessandro Prontera | Match Report | |
| 3 | Sun | 2021-09-12 | 16:15 | Cremonese | 0.5 | 2–0 | 0.9 | Cittadella | 2,817 | Stadio Giovanni Zini | Daniele Paterna | Match Report | |
| 3 | Sun | 2021-09-12 | 20:30 | Pordenone | 0.8 | 0–4 | 1.9 | Parma | 1,830 | Stadio Comunale G.Teghil | Lorenzo Maggioni | Match Report | |
| 4 | Fri | 2021-09-17 | 18:00 | Como | 0.9 | 0–2 | 1.6 | Frosinone | 1,645 | Stadio Giuseppe Sinigaglia | Matteo Marcenaro | Match Report | |
| 4 | Fri | 2021-09-17 | 20:30 | Brescia | 1.4 | 2–2 | 0.8 | Crotone | 4,250 | Stadio Mario Rigamonti | Giacomo Camplone | Match Report | |
| 4 | Sat | 2021-09-18 | 14:00 | Lecce | 2.2 | 3–2 | 0.7 | Alessandria | 5,003 | Stadio Comunale Via Del Mare | Piero Giacomelli | Match Report | |
| 4 | Sat | 2021-09-18 | 14:00 | Perugia | 1.8 | 1–1 | 0.8 | Cosenza | 3,500 | Stadio Renato Curi | Gianpiero Miele | Match Report | |
| 4 | Sat | 2021-09-18 | 14:00 | US Reggina | 2.2 | 2–1 | 1.6 | SPAL | 4,773 | Stadio Oreste Granillo | Niccolò Baroni | Match Report | |
| 4 | Sat | 2021-09-18 | 14:00 | Ascoli | 0.5 | 0–2 | 1.8 | Benevento | 4,545 | Stadio Cino e Lillo Del Duca | Eugenio Abbattista | Match Report | |
| 4 | Sat | 2021-09-18 | 14:00 | Monza | 1.8 | 1–1 | 0.9 | Ternana | 2,332 | U-Power Stadium | Luca Zufferli | Match Report | |
| 4 | Sat | 2021-09-18 | 16:15 | Vicenza Virtus | 0.5 | 1–3 | 0.9 | Pisa | 3,372 | Stadio Romeo Menti | Davide Massa | Match Report | |
| 4 | Sat | 2021-09-18 | 18:30 | Cittadella | 0.9 | 1–0 | 0.6 | Pordenone | 1,326 | Stadio Pier Cesare Tombolato | Andrea Colombo | Match Report | |
| 4 | Sun | 2021-09-19 | 20:30 | Parma | 0.5 | 1–2 | 2.4 | Cremonese | 5,581 | Stadio Ennio Tardini | Manuel Volpi | Match Report | |
| 5 | Mon | 2021-09-20 | 20:30 | Frosinone | 1.9 | 2–2 | 2.6 | Brescia | 6,213 | Stadio Benito Stirpe | Federico Dionisi | Match Report | |
| 5 | Tue | 2021-09-21 | 18:00 | Benevento | 1.9 | 4–1 | 1.8 | Cittadella | 2,994 | Stadio Ciro Vigorito | Cosso Cosso | Match Report | |
| 5 | Tue | 2021-09-21 | 18:00 | Alessandria | 2.1 | 1–3 | 1.3 | Ascoli | 1,912 | Stadio Giuseppe Moccagatta | Daniele Minelli | Match Report | |
| 5 | Tue | 2021-09-21 | 20:30 | SPAL | 1.4 | 3–2 | 0.6 | Vicenza Virtus | 3,599 | Stadio Paolo Mazza | Antonio Di Martino | Match Report | |
| 5 | Tue | 2021-09-21 | 20:30 | Cosenza | 0.2 | 2–0 | 1.0 | Como | 4,500 | Stadio San Vito | Juan Sacchi | Match Report | |
| 5 | Tue | 2021-09-21 | 20:30 | Crotone | 1.3 | 0–3 | 1.7 | Lecce | 2,277 | Stadio Ezio Scida | Daniele Paterna | Match Report | |
| 5 | Tue | 2021-09-21 | 20:30 | Pisa | 1.7 | 2–1 | 1.1 | Monza | 4,635 | Arena Garibaldi - Stadio Romeo Anconetan... | Luca Pairetto | Match Report | |
| 5 | Tue | 2021-09-21 | 20:30 | Pordenone | 0.8 | 1–1 | 1.4 | US Reggina | 815 | Stadio Comunale G.Teghil | Francesco Meraviglia | Match Report | |
| 5 | Wed | 2021-09-22 | 18:00 | Ternana | 1.9 | 3–1 | 1.0 | Parma | 4,611 | Stadio Libero Liberati | Marco Serra | Match Report | |
| 5 | Wed | 2021-09-22 | 20:30 | Cremonese | 2.5 | 0–3 | 1.3 | Perugia | 3,188 | Stadio Giovanni Zini | Matteo Marchetti | Match Report | |
| 6 | Sat | 2021-09-25 | 14:00 | Monza | 2.4 | 3–1 | 1.3 | Pordenone | 2,011 | U-Power Stadium | Niccolò Baroni | Match Report | |
| 6 | Sat | 2021-09-25 | 14:00 | Cittadella | 1.0 | 1–2 | 1.4 | Lecce | 1,773 | Stadio Pier Cesare Tombolato | Matteo Gariglio | Match Report | |
| 6 | Sat | 2021-09-25 | 14:00 | Como | 1.4 | 1–1 | 1.0 | Benevento | 2,189 | Stadio Giuseppe Sinigaglia | Luca Zufferli | Match Report | |
| 6 | Sat | 2021-09-25 | 14:00 | Ascoli | 1.5 | 2–3 | 2.6 | Brescia | 3,901 | Stadio Cino e Lillo Del Duca | Luca Massimi | Match Report | |
| 6 | Sat | 2021-09-25 | 16:15 | US Reggina | 1.1 | 0–0 | 0.9 | Frosinone | 5,034 | Stadio Oreste Granillo | Simone Sozza | Match Report | |
| 6 | Sat | 2021-09-25 | 18:30 | Cosenza | 0.3 | 1–0 | 1.0 | Crotone | 7,554 | Stadio San Vito | Daniele Chiffi | Match Report | |
| 6 | Sun | 2021-09-26 | 14:00 | Perugia | 1.3 | 1–1 | 1.1 | Alessandria | 3,179 | Stadio Renato Curi | Valerio Marini | Match Report | |
| 6 | Sun | 2021-09-26 | 16:15 | Parma | 2.0 | 1–1 | 1.2 | Pisa | 7,245 | Stadio Ennio Tardini | Alessandro Prontera | Match Report | |
| 6 | Sun | 2021-09-26 | 20:30 | Vicenza Virtus | 1.0 | 0–1 | 1.4 | Cremonese | 2,927 | Stadio Romeo Menti | Alberto Santoro | Match Report | |
| 6 | Sun | 2021-09-26 | 20:30 | Ternana | 0.7 | 1–0 | 1.3 | SPAL | 4,369 | Stadio Libero Liberati | Matteo Marcenaro | Match Report | |
| 7 | Fri | 2021-10-01 | 20:30 | Lecce | 1.8 | 3–0 | 0.3 | Monza | 8,442 | Stadio Comunale Via Del Mare | Eugenio Abbattista | Match Report | |
| 7 | Sat | 2021-10-02 | 14:00 | Cremonese | 1.0 | 2–0 | 1.2 | Ternana | 2,813 | Stadio Giovanni Zini | Cosso Cosso | Match Report | |
| 7 | Sat | 2021-10-02 | 14:00 | Crotone | 1.1 | 2–2 | 1.5 | Ascoli | 1,490 | Stadio Ezio Scida | Antonio Di Martino | Match Report | |
| 7 | Sat | 2021-10-02 | 14:00 | Alessandria | 0.9 | 1–0 | 0.2 | Cosenza | 2,345 | Stadio Giuseppe Moccagatta | Michael Fabbri | Match Report | |
| 7 | Sat | 2021-10-02 | 14:00 | Frosinone | 1.1 | 0–1 | 2.8 | Cittadella | 5,509 | Stadio Benito Stirpe | Francesco Meraviglia | Match Report | |
| 7 | Sat | 2021-10-02 | 16:15 | Pisa | 1.6 | 2–0 | 1.8 | US Reggina | 5,029 | Arena Garibaldi - Stadio Romeo Anconetan... | Andrea Colombo | Match Report | |
| 7 | Sat | 2021-10-02 | 18:30 | SPAL | 1.9 | 2–2 | 1.4 | Parma | 3,720 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| 7 | Sun | 2021-10-03 | 14:00 | Brescia | 2.1 | 2–4 | 2.2 | Como | 5,000 | Stadio Mario Rigamonti | Gianpiero Miele | Match Report | |
| 7 | Sun | 2021-10-03 | 16:15 | Pordenone | 1.3 | 2–4 | 3.3 | Vicenza Virtus | 1,512 | Stadio Comunale G.Teghil | Antonio Rapuano | Match Report | |
| 7 | Sun | 2021-10-03 | 20:30 | Benevento | 1.0 | 0–0 | 1.8 | Perugia | 4,326 | Stadio Ciro Vigorito | Livio Marinelli | Match Report | |
| 8 | Sat | 2021-10-16 | 14:00 | Vicenza Virtus | 1.0 | 0–1 | 1.0 | US Reggina | 5,251 | Stadio Romeo Menti | Matteo Gariglio | Match Report | |
| 8 | Sat | 2021-10-16 | 14:00 | Crotone | 1.5 | 2–1 | 2.6 | Pisa | 1,962 | Stadio Ezio Scida | Niccolò Baroni | Match Report | |
| 8 | Sat | 2021-10-16 | 14:00 | Ascoli | 1.0 | 1–1 | 1.5 | Lecce | 4,390 | Stadio Cino e Lillo Del Duca | Federico Dionisi | Match Report | |
| 8 | Sat | 2021-10-16 | 14:00 | Pordenone | 1.4 | 1–3 | 1.7 | Ternana | 857 | Stadio Comunale G.Teghil | Daniele Minelli | Match Report | |
| 8 | Sat | 2021-10-16 | 16:15 | Cosenza | 0.9 | 1–1 | 2.0 | Frosinone | 5,414 | Stadio San Vito | Francesco Fourneau | Match Report | |
| 8 | Sat | 2021-10-16 | 16:15 | Perugia | 1.2 | 1–0 | 0.3 | Brescia | 4,369 | Stadio Renato Curi | Marco Guida | Match Report | |
| 8 | Sat | 2021-10-16 | 18:30 | Como | 1.4 | 2–0 | 0.4 | Alessandria | 2,869 | Stadio Giuseppe Sinigaglia | Ivan Pezzuto | Match Report | |
| 8 | Sun | 2021-10-17 | 14:00 | Cremonese | 1.4 | 1–1 | 1.2 | Benevento | 4,302 | Stadio Giovanni Zini | Matteo Marcenaro | Match Report | |
| 8 | Sun | 2021-10-17 | 16:15 | Parma | 1.3 | 0–0 | 0.8 | Monza | 7,555 | Stadio Ennio Tardini | Fabio Maresca | Match Report | |
| 8 | Sun | 2021-10-17 | 20:30 | Cittadella | 0.8 | 0–0 | 0.8 | SPAL | 2,233 | Stadio Pier Cesare Tombolato | Maria Sole Ferrieri Caputi | Match Report | |
| 9 | Fri | 2021-10-22 | 20:30 | Alessandria | 2.8 | 1–0 | 0.8 | Crotone | 2,528 | Stadio Giuseppe Moccagatta | Alberto Santoro | Match Report | |
| 9 | Sat | 2021-10-23 | 14:00 | Benevento | 3.2 | 3–0 | 0.7 | Cosenza | 3,930 | Stadio Ciro Vigorito | Davide Ghersini | Match Report | |
| 9 | Sat | 2021-10-23 | 14:00 | Ternana | 2.2 | 5–0 | 1.2 | Vicenza Virtus | 3,723 | Stadio Libero Liberati | Manuel Volpi | Match Report | |
| 9 | Sat | 2021-10-23 | 14:00 | Monza | 0.9 | 1–0 | 1.1 | Cittadella | 2,521 | U-Power Stadium | Gianluca Manganiello | Match Report | |
| 9 | Sat | 2021-10-23 | 14:00 | Lecce | 1.2 | 0–0 | 0.3 | Perugia | 6,665 | Stadio Comunale Via Del Mare | Antonio Giua | Match Report | |
| 9 | Sat | 2021-10-23 | 16:15 | Frosinone | 1.6 | 2–1 | 0.7 | Ascoli | 6,164 | Stadio Benito Stirpe | Lorenzo Maggioni | Match Report | |
| 9 | Sat | 2021-10-23 | 18:30 | Brescia | 0.5 | 1–0 | 1.5 | Cremonese | 6,500 | Stadio Mario Rigamonti | Gianluca Aureliano | Match Report | |
| 9 | Sun | 2021-10-24 | 14:00 | Pisa | 0.5 | 1–1 | 1.7 | Pordenone | 6,388 | Arena Garibaldi - Stadio Romeo Anconetan... | Paride Tremolada | Match Report | |
| 9 | Sun | 2021-10-24 | 16:15 | US Reggina | 2.9 | 2–1 | 0.6 | Parma | 8,693 | Stadio Oreste Granillo | Luca Zufferli | Match Report | |
| 9 | Sun | 2021-10-24 | 20:30 | SPAL | 1.5 | 1–1 | 1.6 | Como | 4,915 | Stadio Paolo Mazza | Eugenio Abbattista | Match Report | |
| 10 | Wed | 2021-10-27 | 18:00 | Cosenza | 1.0 | 3–1 | 2.6 | Ternana | 3,149 | Stadio San Vito | Andrea Colombo | Match Report | |
| 10 | Wed | 2021-10-27 | 20:30 | Vicenza Virtus | 0.7 | 1–1 | 1.0 | Monza | 4,312 | Stadio Romeo Menti | Luca Pairetto | Match Report | |
| 10 | Thu | 2021-10-28 | 18:00 | Brescia | 2.1 | 1–1 | 0.7 | Lecce | 5,938 | Stadio Mario Rigamonti | Massimiliano Irrati | Match Report | |
| 10 | Thu | 2021-10-28 | 18:00 | Alessandria | 0.7 | 1–1 | 1.4 | Frosinone | 2,432 | Stadio Giuseppe Moccagatta | Cosso Cosso | Match Report | |
| 10 | Thu | 2021-10-28 | 18:00 | Ascoli | 0.9 | 0–1 | 0.5 | SPAL | 3,979 | Stadio Cino e Lillo Del Duca | Gianpiero Miele | Match Report | |
| 10 | Thu | 2021-10-28 | 20:30 | Cremonese | 1.6 | 1–1 | 1.2 | Pisa | 5,543 | Stadio Giovanni Zini | Daniele Orsato | Match Report | |
| 10 | Thu | 2021-10-28 | 20:30 | Cittadella | 2.0 | 1–2 | 0.5 | Parma | 3,161 | Stadio Pier Cesare Tombolato | Federico Dionisi | Match Report | |
| 10 | Thu | 2021-10-28 | 20:30 | Crotone | 0.5 | 0–2 | 1.7 | Benevento | 1,949 | Stadio Ezio Scida | Francesco Meraviglia | Match Report | |
| 10 | Thu | 2021-10-28 | 20:30 | Perugia | 1.3 | 0–2 | 0.6 | US Reggina | 4,223 | Stadio Renato Curi | Giacomo Camplone | Match Report | |
| 10 | Thu | 2021-10-28 | 20:30 | Como | 1.6 | 1–0 | 1.5 | Pordenone | 2,065 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| 11 | Mon | 2021-11-01 | 12:30 | Benevento | 0.9 | 0–1 | 0.9 | Brescia | 4,453 | Stadio Ciro Vigorito | Piero Giacomelli | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | SPAL | 1.7 | 1–2 | 3.1 | Perugia | 5,134 | Stadio Paolo Mazza | Luca Zufferli | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | Ternana | 2.4 | 1–2 | 0.9 | Como | 3,426 | Stadio Libero Liberati | Rosario Abisso | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | Frosinone | 1.7 | 2–1 | 2.0 | Crotone | 5,673 | Stadio Benito Stirpe | Eugenio Abbattista | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | Monza | 0.6 | 1–0 | 0.6 | Alessandria | 3,145 | U-Power Stadium | Matteo Gariglio | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | US Reggina | 1.8 | 0–1 | 1.6 | Cittadella | 6,292 | Stadio Oreste Granillo | Daniele Minelli | Match Report | |
| 11 | Mon | 2021-11-01 | 15:00 | Lecce | 1.8 | 3–1 | 0.4 | Cosenza | 6,556 | Stadio Comunale Via Del Mare | Alberto Santoro | Match Report | |
| 11 | Mon | 2021-11-01 | 18:00 | Pisa | 0.7 | 1–1 | 1.6 | Ascoli | 4,732 | Arena Garibaldi - Stadio Romeo Anconetan... | Matteo Marcenaro | Match Report | |
| 11 | Mon | 2021-11-01 | 18:00 | Pordenone | 1.0 | 2–2 | 0.9 | Cremonese | 917 | Stadio Comunale G.Teghil | Lorenzo Maggioni | Match Report | |
| 11 | Mon | 2021-11-01 | 18:00 | Parma | 0.8 | 1–0 | 0.7 | Vicenza Virtus | 5,116 | Stadio Ennio Tardini | Niccolò Baroni | Match Report | |
| 12 | Fri | 2021-11-05 | 20:30 | Cosenza | 1.2 | 0–1 | 0.8 | US Reggina | 8,506 | Stadio San Vito | Antonio Di Martino | Match Report | |
| 12 | Sat | 2021-11-06 | 14:00 | Ascoli | 1.7 | 2–1 | 1.1 | Vicenza Virtus | 3,306 | Stadio Cino e Lillo Del Duca | Daniele Paterna | Match Report | |
| 12 | Sat | 2021-11-06 | 14:00 | Cremonese | 1.5 | 1–1 | 1.1 | SPAL | 3,868 | Stadio Giovanni Zini | Andrea Colombo | Match Report | |
| 12 | Sat | 2021-11-06 | 14:00 | Como | 2.0 | 4–1 | 1.5 | Perugia | 2,471 | Stadio Giuseppe Sinigaglia | Cosso Cosso | Match Report | |
| 12 | Sat | 2021-11-06 | 14:00 | Alessandria | 1.4 | 0–2 | 0.9 | Ternana | 2,198 | Stadio Giuseppe Moccagatta | Giacomo Camplone | Match Report | |
| 12 | Sat | 2021-11-06 | 16:15 | Brescia | 0.6 | 1–0 | 0.7 | Pordenone | 4,900 | Stadio Mario Rigamonti | Manuel Volpi | Match Report | |
| 12 | Sat | 2021-11-06 | 18:30 | Benevento | 1.4 | 1–4 | 2.3 | Frosinone | 2,467 | Stadio Ciro Vigorito | Matteo Marchetti | Match Report | |
| 12 | Sun | 2021-11-07 | 14:00 | Lecce | 2.5 | 4–0 | 0.7 | Parma | 18,765 | Stadio Comunale Via Del Mare | Davide Ghersini | Match Report | |
| 12 | Sun | 2021-11-07 | 16:15 | Crotone | 1.4 | 1–1 | 0.8 | Monza | 2,226 | Stadio Ezio Scida | Marco Di Bello | Match Report | |
| 12 | Sun | 2021-11-07 | 20:30 | Cittadella | 1.0 | 2–0 | 0.3 | Pisa | 1,472 | Stadio Pier Cesare Tombolato | Francesco Meraviglia | Match Report | |
| 13 | Sat | 2021-11-20 | 14:00 | Frosinone | 0.8 | 0–0 | 1.2 | Lecce | 7,883 | Stadio Benito Stirpe | Michael Fabbri | Match Report | |
| 13 | Sat | 2021-11-20 | 14:00 | Ternana | 1.6 | 1–1 | 1.7 | Cittadella | 3,350 | Stadio Libero Liberati | Alessandro Prontera | Match Report | |
| 13 | Sat | 2021-11-20 | 14:00 | SPAL | 1.3 | 2–3 | 1.3 | Alessandria | 4,546 | Stadio Paolo Mazza | Matteo Marcenaro | Match Report | |
| 13 | Sat | 2021-11-20 | 14:00 | Pordenone | 0.4 | 0–1 | 1.7 | Ascoli | 994 | Stadio Comunale G.Teghil | Alberto Santoro | Match Report | |
| 13 | Sat | 2021-11-20 | 16:15 | Perugia | 1.2 | 2–0 | 0.8 | Crotone | 3,177 | Stadio Renato Curi | Daniele Minelli | Match Report | |
| 13 | Sat | 2021-11-20 | 18:30 | Vicenza Virtus | 2.2 | 2–3 | 1.6 | Brescia | 7,171 | Stadio Romeo Menti | Eugenio Abbattista | Match Report | |
| 13 | Sun | 2021-11-21 | 14:00 | US Reggina | 0.7 | 1–2 | 3.8 | Cremonese | 6,335 | Stadio Oreste Granillo | Livio Marinelli | Match Report | |
| 13 | Sun | 2021-11-21 | 14:00 | Parma | 0.7 | 1–1 | 1.3 | Cosenza | 6,137 | Stadio Ennio Tardini | Gianpiero Miele | Match Report | |
| 13 | Sun | 2021-11-21 | 16:15 | Monza | 1.5 | 3–2 | 1.4 | Como | 6,525 | U-Power Stadium | Marco Serra | Match Report | |
| 13 | Sun | 2021-11-21 | 20:30 | Pisa | 0.7 | 1–0 | 1.4 | Benevento | 5,208 | Arena Garibaldi - Stadio Romeo Anconetan... | Maurizio Mariani | Match Report | |
| 14 | Fri | 2021-11-26 | 18:00 | Crotone | 0.5 | 0–1 | 1.5 | Vicenza Virtus | 1,856 | Stadio Ezio Scida | Antonio Giua | Match Report | |
| 14 | Fri | 2021-11-26 | 20:30 | Lecce | 1.3 | 3–3 | 2.1 | Ternana | 10,314 | Stadio Comunale Via Del Mare | Daniele Paterna | Match Report | |
| 14 | Sat | 2021-11-27 | 14:00 | Alessandria | 1.1 | 1–0 | 1.0 | Cremonese | 2,290 | Stadio Giuseppe Moccagatta | Manuel Volpi | Match Report | |
| 14 | Sat | 2021-11-27 | 14:00 | Ascoli | 2.1 | 1–1 | 1.4 | Monza | 3,948 | Stadio Cino e Lillo Del Duca | Antonio Di Martino | Match Report | |
| 14 | Sat | 2021-11-27 | 14:00 | Benevento | 3.7 | 4–0 | 0.5 | US Reggina | 4,088 | Stadio Ciro Vigorito | Francesco Fourneau | Match Report | |
| 14 | Sat | 2021-11-27 | 14:00 | Frosinone | 2.6 | 2–2 | 2.1 | Pordenone | 4,609 | Stadio Benito Stirpe | Antonio Rapuano | Match Report | |
| 14 | Sat | 2021-11-27 | 14:00 | Cosenza | 0.9 | 0–1 | 0.5 | SPAL | 2,269 | Stadio San Vito | Fabio Maresca | Match Report | |
| 14 | Sat | 2021-11-27 | 16:15 | Brescia | 0.2 | 0–1 | 0.9 | Pisa | 6,211 | Stadio Mario Rigamonti | Simone Sozza | Match Report | |
| 14 | Sat | 2021-11-27 | 18:30 | Perugia | 1.1 | 1–1 | 2.2 | Cittadella | 2,544 | Stadio Renato Curi | Alessandro Prontera | Match Report | |
| 14 | Sun | 2021-11-28 | 20:30 | Como | 2.1 | 1–1 | 1.7 | Parma | 3,191 | Stadio Giuseppe Sinigaglia | Davide Massa | Match Report | |
| 15 | Mon | 2021-11-29 | 20:30 | Ternana | 1.4 | 1–0 | 1.6 | Crotone | 2,077 | Stadio Libero Liberati | Marco Serra | Match Report | |
| 15 | Tue | 2021-11-30 | 18:00 | Cremonese | 2.0 | 1–1 | 0.9 | Frosinone | 2,096 | Stadio Giovanni Zini | Giacomo Camplone | Match Report | |
| 15 | Tue | 2021-11-30 | 18:00 | Pisa | 1.8 | 1–1 | 1.8 | Perugia | 4,127 | Arena Garibaldi - Stadio Romeo Anconetan... | Gianpiero Miele | Match Report | |
| 15 | Tue | 2021-11-30 | 20:30 | Pordenone | 1.5 | 2–0 | 1.0 | Alessandria | 635 | Stadio Comunale G.Teghil | Matteo Marchetti | Match Report | |
| 15 | Tue | 2021-11-30 | 20:30 | US Reggina | 1.5 | 1–2 | 0.8 | Ascoli | 4,229 | Stadio Oreste Granillo | Rosario Abisso | Match Report | |
| 15 | Tue | 2021-11-30 | 20:30 | Monza | 1.0 | 4–1 | 0.6 | Cosenza | 3,450 | U-Power Stadium | Daniele Minelli | Match Report | |
| 15 | Tue | 2021-11-30 | 20:30 | SPAL | 1.1 | 1–3 | 1.3 | Lecce | 4,157 | Stadio Paolo Mazza | Marco Guida | Match Report | |
| 15 | Tue | 2021-11-30 | 20:30 | Vicenza Virtus | 1.4 | 2–3 | 1.6 | Benevento | 3,789 | Stadio Romeo Menti | Paolo Valeri | Match Report | |
| 15 | Wed | 2021-12-01 | 18:00 | Parma | 0.9 | 0–1 | 1.1 | Brescia | 5,138 | Stadio Ennio Tardini | Cosso Cosso | Match Report | |
| 15 | Wed | 2021-12-01 | 20:30 | Cittadella | 1.2 | 2–2 | 2.3 | Como | 1,355 | Stadio Pier Cesare Tombolato | Eugenio Abbattista | Match Report | |
| 16 | Fri | 2021-12-03 | 20:30 | Perugia | 0.9 | 1–0 | 1.0 | Vicenza Virtus | 3,114 | Stadio Renato Curi | Gianluca Manganiello | Match Report | |
| 16 | Sat | 2021-12-04 | 14:00 | Frosinone | 0.7 | 1–1 | 1.8 | Ternana | 5,409 | Stadio Benito Stirpe | Cosso Cosso | Match Report | |
| 16 | Sat | 2021-12-04 | 14:00 | Benevento | 1.9 | 2–1 | 0.8 | Pordenone | 4,168 | Stadio Ciro Vigorito | Antonio Di Martino | Match Report | |
| 16 | Sat | 2021-12-04 | 14:00 | Crotone | 1.5 | 1–2 | 1.4 | SPAL | 2,176 | Stadio Ezio Scida | Simone Sozza | Match Report | |
| 16 | Sat | 2021-12-04 | 14:00 | Cosenza | 0.6 | 0–2 | 1.7 | Cremonese | 2,728 | Stadio San Vito | Lorenzo Maggioni | Match Report | |
| 16 | Sat | 2021-12-04 | 16:15 | Lecce | 1.5 | 2–0 | 0.8 | US Reggina | 9,026 | Stadio Comunale Via Del Mare | Manuel Volpi | Match Report | |
| 16 | Sun | 2021-12-05 | 14:00 | Ascoli | 1.1 | 0–0 | 1.0 | Parma | 6,837 | Stadio Cino e Lillo Del Duca | Daniele Minelli | Match Report | |
| 16 | Sun | 2021-12-05 | 14:00 | Como | 1.4 | 0–1 | 0.9 | Pisa | 2,471 | Stadio Giuseppe Sinigaglia | Daniele Doveri | Match Report | |
| 16 | Sun | 2021-12-05 | 16:15 | Brescia | 1.1 | 0–2 | 1.8 | Monza | 5,080 | Stadio Mario Rigamonti | Luca Pairetto | Match Report | |
| 16 | Sun | 2021-12-05 | 20:30 | Alessandria | 1.3 | 0–1 | 1.1 | Cittadella | 1,804 | Stadio Giuseppe Moccagatta | Giovanni Ayroldi | Match Report | |
| 17 | Fri | 2021-12-10 | 18:00 | Cremonese | 1.7 | 3–2 | 2.2 | Crotone | 1,495 | Stadio Giovanni Zini | Matteo Marcenaro | Match Report | |
| 17 | Fri | 2021-12-10 | 20:30 | Ternana | 1.2 | 0–2 | 2.6 | Benevento | 1,900 | Stadio Libero Liberati | Francesco Meraviglia | Match Report | |
| 17 | Sat | 2021-12-11 | 14:00 | Monza | 2.1 | 3–2 | 1.4 | Frosinone | 2,660 | U-Power Stadium | Ivan Pezzuto | Match Report | |
| 17 | Sat | 2021-12-11 | 14:00 | SPAL | 0.9 | 0–2 | 2.4 | Brescia | 3,814 | Stadio Paolo Mazza | Piero Giacomelli | Match Report | |
| 17 | Sat | 2021-12-11 | 14:00 | Cittadella | 3.3 | 2–0 | 0.3 | Ascoli | 1,429 | Stadio Pier Cesare Tombolato | Andrea Colombo | Match Report | |
| 17 | Sat | 2021-12-11 | 14:00 | Pordenone | 1.8 | 1–1 | 0.4 | Cosenza | 847 | Stadio Comunale G.Teghil | Marco Piccinini | Match Report | |
| 17 | Sat | 2021-12-11 | 16:15 | Pisa | 0.6 | 1–0 | 1.5 | Lecce | 7,401 | Arena Garibaldi - Stadio Romeo Anconetan... | Daniele Orsato | Match Report | |
| 17 | Sun | 2021-12-12 | 14:00 | Parma | 1.5 | 1–1 | 0.5 | Perugia | 4,935 | Stadio Ennio Tardini | Alberto Santoro | Match Report | |
| 17 | Sun | 2021-12-12 | 16:15 | Vicenza Virtus | 2.2 | 0–1 | 0.3 | Como | 3,880 | Stadio Romeo Menti | Antonio Rapuano | Match Report | |
| 17 | Sun | 2021-12-12 | 20:30 | US Reggina | 0.4 | 0–4 | 2.6 | Alessandria | 3,913 | Stadio Oreste Granillo | Giacomo Camplone | Match Report | |
| 18 | Sat | 2021-12-18 | 14:00 | Cosenza | 1.3 | 0–2 | 2.4 | Pisa | 2,079 | Stadio San Vito | Daniele Chiffi | Match Report | |
| 18 | Sat | 2021-12-18 | 14:00 | Crotone | 2.0 | 4–1 | 1.2 | Pordenone | 1,529 | Stadio Ezio Scida | Giovanni Ayroldi | Match Report | |
| 18 | Sat | 2021-12-18 | 14:00 | Como | 2.3 | 1–1 | 2.5 | US Reggina | 3,098 | Stadio Giuseppe Sinigaglia | Gianpiero Miele | Match Report | |
| 18 | Sat | 2021-12-18 | 14:00 | Ascoli | 0.8 | 1–4 | 2.0 | Cremonese | 3,115 | Stadio Cino e Lillo Del Duca | Luca Zufferli | Match Report | |
| 18 | Sat | 2021-12-18 | 16:15 | Frosinone | 2.5 | 4–0 | 1.0 | SPAL | 3,208 | Stadio Benito Stirpe | Matteo Marchetti | Match Report | |
| 18 | Sun | 2021-12-19 | 14:00 | Alessandria | 0.9 | 0–2 | 2.2 | Parma | 4,097 | Stadio Giuseppe Moccagatta | Gianluca Manganiello | Match Report | |
| 18 | Sun | 2021-12-19 | 14:00 | Brescia | 1.0 | 1–1 | 1.1 | Cittadella | 3,275 | Stadio Mario Rigamonti | Daniele Paterna | Match Report | |
| 18 | Sun | 2021-12-19 | 16:15 | Perugia | 1.5 | 1–1 | 0.9 | Ternana | 7,556 | Stadio Renato Curi | Marco Guida | Match Report | |
| 18 | Thu | 2022-01-13 | 20:30 | Benevento | 2.5 | 3–1 | 1.9 | Monza | 5,502 | Stadio Ciro Vigorito | Paolo Valeri | Match Report | |
| 19 | Fri | 2022-01-14 | 20:30 | Ternana | 1.5 | 2–4 | 2.4 | Ascoli | 1,147 | Stadio Libero Liberati | Valerio Marini | Match Report | |
| 19 | Sat | 2022-01-15 | 14:00 | Cremonese | 2.5 | 2–0 | 0.9 | Como | 1,580 | Stadio Giovanni Zini | Matteo Gariglio | Match Report | |
| 19 | Sat | 2022-01-15 | 14:00 | US Reggina | 0.6 | 0–2 | 1.9 | Brescia | 3,408 | Stadio Oreste Granillo | Alberto Santoro | Match Report | |
| 19 | Sat | 2022-01-15 | 16:15 | Pisa | 0.5 | 1–3 | 2.2 | Frosinone | 3,047 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| 19 | Sun | 2022-01-16 | 16:15 | Monza | 2.7 | 2–2 | 2.4 | Perugia | 2,493 | U-Power Stadium | Eugenio Abbattista | Match Report | |
| 19 | Sun | 2022-01-16 | 16:15 | SPAL | 1.1 | 1–1 | 1.3 | Benevento | 2,546 | Stadio Paolo Mazza | Niccolò Baroni | Match Report | |
| 19 | Sun | 2022-01-16 | 16:15 | Pordenone | 0.1 | 0–1 | 1.8 | Lecce | 976 | Stadio Comunale G.Teghil | Andrea Colombo | Match Report | |
| 20 | Fri | 2022-01-21 | 20:30 | Parma | 1.1 | 0–1 | 1.3 | Frosinone | 4,056 | Stadio Ennio Tardini | Antonio Di Martino | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | Cosenza | 0.4 | 1–3 | 2.0 | Ascoli | 892 | Stadio San Vito | Francesco Meraviglia | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | SPAL | 0.9 | 0–0 | 1.0 | Pisa | 2,859 | Stadio Paolo Mazza | Giovanni Ayroldi | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | Brescia | 1.3 | 1–1 | 0.7 | Ternana | 3,596 | Stadio Mario Rigamonti | Federico Dionisi | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | Alessandria | 1.2 | 2–0 | 1.0 | Benevento | 1,803 | Stadio Giuseppe Moccagatta | Antonio Rapuano | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | Como | 1.4 | 1–1 | 1.1 | Crotone | 1,540 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| 20 | Sat | 2022-01-22 | 14:00 | Monza | 1.9 | 1–0 | 0.1 | US Reggina | 3,387 | U-Power Stadium | Giacomo Camplone | Match Report | |
| 20 | Sat | 2022-01-22 | 16:15 | Perugia | 1.1 | 0–1 | 0.8 | Pordenone | 2,798 | Stadio Renato Curi | Gianpiero Miele | Match Report | |
| 20 | Sun | 2022-01-23 | 16:15 | Vicenza Virtus | 2.8 | 3–3 | 2.8 | Cittadella | 4,038 | Stadio Romeo Menti | Valerio Marini | Match Report | |
| 20 | Sun | 2022-01-23 | 18:30 | Lecce | 0.8 | 2–1 | 0.5 | Cremonese | 3,080 | Stadio Comunale Via Del Mare | Daniele Chiffi | Match Report | |
| 18 | Wed | 2022-01-26 | 20:00 | Lecce | 2.8 | 2–1 | 0.8 | Vicenza Virtus | 6,422 | Stadio Comunale Via Del Mare | Marco Guida | Match Report | |
| 19 | Sun | 2022-01-30 | 14:30 | Vicenza Virtus | 1.3 | 2–1 | 0.7 | Alessandria | 4,613 | Stadio Romeo Menti | Davide Ghersini | Match Report | |
| 19 | Sun | 2022-01-30 | 14:30 | Cittadella | 1.2 | 1–1 | 1.0 | Cosenza | 1,730 | Stadio Pier Cesare Tombolato | Niccolò Baroni | Match Report | |
| 19 | Sun | 2022-01-30 | 14:30 | Parma | 1.2 | 1–1 | 0.8 | Crotone | 4,934 | Stadio Ennio Tardini | Francesco Meraviglia | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Alessandria | 1.3 | 1–1 | 1.8 | Pisa | 2,099 | Stadio Giuseppe Moccagatta | Ivan Pezzuto | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Benevento | 1.5 | 0–0 | 1.2 | Parma | 3,135 | Stadio Ciro Vigorito | Livio Marinelli | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Crotone | 1.1 | 0–0 | 0.5 | Cittadella | 1,809 | Stadio Ezio Scida | Eugenio Abbattista | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Cosenza | 1.1 | 0–0 | 1.4 | Brescia | 1,649 | Stadio San Vito | Gianluca Aureliano | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Como | 2.1 | 1–1 | 2.6 | Lecce | 2,499 | Stadio Giuseppe Sinigaglia | Marco Piccinini | Match Report | |
| 21 | Sat | 2022-02-05 | 14:00 | Ternana | 2.1 | 2–0 | 0.5 | US Reggina | 2,361 | Stadio Libero Liberati | Andrea Colombo | Match Report | |
| 21 | Sat | 2022-02-05 | 16:15 | Frosinone | 3.6 | 2–0 | 1.4 | Vicenza Virtus | 4,337 | Stadio Benito Stirpe | Piero Giacomelli | Match Report | |
| 21 | Sat | 2022-02-05 | 18:30 | Ascoli | 0.5 | 0–1 | 0.9 | Perugia | 3,374 | Stadio Cino e Lillo Del Duca | Matteo Marcenaro | Match Report | |
| 21 | Sun | 2022-02-06 | 16:15 | Pordenone | 2.1 | 1–1 | 2.1 | SPAL | 1,213 | Stadio Comunale G.Teghil | Alberto Santoro | Match Report | |
| 21 | Sun | 2022-02-06 | 16:15 | Cremonese | 1.1 | 3–2 | 1.2 | Monza | 4,062 | Stadio Giovanni Zini | Davide Massa | Match Report | |
| 22 | Sat | 2022-02-12 | 14:00 | Parma | 2.4 | 4–1 | 0.6 | Pordenone | 4,614 | Stadio Ennio Tardini | Giacomo Camplone | Match Report | |
| 22 | Sat | 2022-02-12 | 14:00 | Monza | 2.8 | 4–0 | 0.1 | SPAL | 3,212 | U-Power Stadium | Gianpiero Miele | Match Report | |
| 22 | Sat | 2022-02-12 | 14:00 | Cittadella | 0.6 | 0–2 | 1.2 | Cremonese | 1,526 | Stadio Pier Cesare Tombolato | Daniele Minelli | Match Report | |
| 22 | Sat | 2022-02-12 | 14:00 | Pisa | 1.8 | 0–0 | 0.4 | Ternana | 4,446 | Arena Garibaldi - Stadio Romeo Anconetan... | Davide Ghersini | Match Report | |
| 22 | Sat | 2022-02-12 | 14:00 | Vicenza Virtus | 0.6 | 0–0 | 1.3 | Cosenza | 4,748 | Stadio Romeo Menti | Lorenzo Maggioni | Match Report | |
| 22 | Sat | 2022-02-12 | 16:15 | Perugia | 2.6 | 3–0 | 1.3 | Frosinone | 3,497 | Stadio Renato Curi | Marco Serra | Match Report | |
| 22 | Sat | 2022-02-12 | 16:15 | US Reggina | 0.5 | 1–0 | 0.7 | Crotone | 5,882 | Stadio Oreste Granillo | Matteo Gariglio | Match Report | |
| 22 | Sun | 2022-02-13 | 15:30 | Lecce | 1.3 | 1–1 | 1.2 | Benevento | 9,580 | Stadio Comunale Via Del Mare | Luca Pairetto | Match Report | |
| 22 | Sun | 2022-02-13 | 15:30 | Ascoli | 1.8 | 1–1 | 1.0 | Como | 3,673 | Stadio Cino e Lillo Del Duca | Giovanni Ayroldi | Match Report | |
| 22 | Sun | 2022-02-13 | 15:30 | Brescia | 0.8 | 1–1 | 1.2 | Alessandria | 4,151 | Stadio Mario Rigamonti | Daniele Paterna | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | Ternana | 0.9 | 0–1 | 1.9 | Monza | 1,713 | Stadio Libero Liberati | Francesco Meraviglia | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | Cremonese | 1.1 | 3–1 | 2.5 | Parma | 4,847 | Stadio Giovanni Zini | Cosso Cosso | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | Pordenone | 0.9 | 0–1 | 2.0 | Cittadella | 468 | Stadio Comunale G.Teghil | Simone Sozza | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | SPAL | 0.5 | 1–3 | 1.3 | US Reggina | 3,885 | Stadio Paolo Mazza | Niccolò Baroni | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | Cosenza | 1.1 | 1–2 | 2.1 | Perugia | 1,489 | Stadio San Vito | Juan Sacchi | Match Report | |
| 23 | Tue | 2022-02-15 | 18:30 | Pisa | 2.9 | 2–2 | 1.3 | Vicenza Virtus | 3,057 | Arena Garibaldi - Stadio Romeo Anconetan... | Antonio Di Martino | Match Report | |
| 23 | Wed | 2022-02-16 | 18:30 | Frosinone | 1.8 | 1–2 | 0.4 | Como | 4,293 | Stadio Benito Stirpe | Valerio Marini | Match Report | |
| 23 | Wed | 2022-02-16 | 18:30 | Benevento | 0.8 | 0–2 | 1.5 | Ascoli | 1,980 | Stadio Ciro Vigorito | Alberto Santoro | Match Report | |
| 23 | Wed | 2022-02-16 | 18:30 | Alessandria | 1.3 | 1–1 | 0.6 | Lecce | 2,109 | Stadio Giuseppe Moccagatta | Gianluca Manganiello | Match Report | |
| 23 | Wed | 2022-02-16 | 18:30 | Crotone | 0.2 | 0–1 | 2.0 | Brescia | 1,595 | Stadio Ezio Scida | Manuel Volpi | Match Report | |
| 24 | Sat | 2022-02-19 | 14:00 | US Reggina | 0.9 | 2–0 | 0.7 | Pordenone | 3,685 | Stadio Oreste Granillo | Lorenzo Maggioni | Match Report | |
| 24 | Sat | 2022-02-19 | 14:00 | Vicenza Virtus | 1.0 | 1–1 | 0.6 | SPAL | 4,522 | Stadio Romeo Menti | Gianluca Aureliano | Match Report | |
| 24 | Sat | 2022-02-19 | 14:00 | Monza | 0.9 | 1–2 | 1.2 | Pisa | 4,572 | U-Power Stadium | Fabio Maresca | Match Report | |
| 24 | Sat | 2022-02-19 | 14:00 | Parma | 3.1 | 2–3 | 2.4 | Ternana | 4,629 | Stadio Ennio Tardini | Daniele Minelli | Match Report | |
| 24 | Sat | 2022-02-19 | 14:00 | Ascoli | 1.1 | 3–0 | 0.5 | Alessandria | 3,609 | Stadio Cino e Lillo Del Duca | Gianpiero Miele | Match Report | |
| 24 | Sat | 2022-02-19 | 16:15 | Perugia | 0.2 | 0–0 | 0.7 | Cremonese | 4,521 | Stadio Renato Curi | Ivan Pezzuto | Match Report | |
| 24 | Sun | 2022-02-20 | 15:30 | Brescia | 1.7 | 2–2 | 1.8 | Frosinone | 3,844 | Stadio Mario Rigamonti | Eugenio Abbattista | Match Report | |
| 24 | Sun | 2022-02-20 | 15:30 | Como | 1.9 | 2–1 | 0.2 | Cosenza | 2,680 | Stadio Giuseppe Sinigaglia | Alessandro Prontera | Match Report | |
| 24 | Sun | 2022-02-20 | 15:30 | Cittadella | 0.5 | 0–1 | 1.1 | Benevento | 1,565 | Stadio Pier Cesare Tombolato | Matteo Gariglio | Match Report | |
| 24 | Sun | 2022-02-20 | 15:30 | Lecce | 3.8 | 3–0 | 0.4 | Crotone | 8,196 | Stadio Comunale Via Del Mare | Davide Ghersini | Match Report | |
| 25 | Tue | 2022-02-22 | 18:30 | Pordenone | 1.3 | 1–4 | 2.8 | Monza | 618 | Stadio Comunale G.Teghil | Marco Serra | Match Report | |
| 25 | Tue | 2022-02-22 | 18:30 | Cremonese | 2.1 | 0–0 | 1.4 | Vicenza Virtus | 3,207 | Stadio Giovanni Zini | Andrea Colombo | Match Report | |
| 25 | Tue | 2022-02-22 | 18:30 | Alessandria | 1.2 | 1–2 | 1.3 | Perugia | 1,745 | Stadio Giuseppe Moccagatta | Marco Piccinini | Match Report | |
| 25 | Tue | 2022-02-22 | 18:30 | Pisa | 0.8 | 0–0 | 1.3 | Parma | 5,560 | Arena Garibaldi - Stadio Romeo Anconetan... | Rosario Abisso | Match Report | |
| 25 | Tue | 2022-02-22 | 18:30 | SPAL | 2.2 | 5–1 | 1.8 | Ternana | 3,474 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| 25 | Wed | 2022-02-23 | 18:30 | Frosinone | 1.6 | 3–0 | 0.0 | US Reggina | 4,004 | Stadio Benito Stirpe | Francesco Meraviglia | Match Report | |
| 25 | Wed | 2022-02-23 | 18:30 | Crotone | 2.9 | 3–3 | 2.5 | Cosenza | 3,704 | Stadio Ezio Scida | Davide Massa | Match Report | |
| 25 | Wed | 2022-02-23 | 18:30 | Benevento | 2.8 | 5–0 | 0.2 | Como | 2,195 | Stadio Ciro Vigorito | Valerio Marini | Match Report | |
| 25 | Wed | 2022-02-23 | 18:30 | Brescia | 1.7 | 2–0 | 0.8 | Ascoli | 3,051 | Stadio Mario Rigamonti | Antonio Di Martino | Match Report | |
| 25 | Wed | 2022-02-23 | 18:30 | Lecce | 2.0 | 1–2 | 0.5 | Cittadella | 6,235 | Stadio Comunale Via Del Mare | Giacomo Camplone | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Como | 0.6 | 1–1 | 1.4 | Brescia | 2,588 | Stadio Giuseppe Sinigaglia | Massimiliano Irrati | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Cosenza | 1.1 | 2–1 | 0.4 | Alessandria | 3,051 | Stadio San Vito | Maurizio Mariani | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Parma | 1.4 | 4–0 | 1.3 | SPAL | 5,286 | Stadio Ennio Tardini | Valerio Marini | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Ternana | 0.5 | 1–2 | 1.4 | Cremonese | 2,022 | Stadio Libero Liberati | Antonio Giua | Match Report | |
| 26 | Sat | 2022-02-26 | 14:00 | Vicenza Virtus | 0.6 | 1–0 | 0.6 | Pordenone | 5,125 | Stadio Romeo Menti | Gianluca Manganiello | Match Report | |
| 26 | Sat | 2022-02-26 | 16:15 | Perugia | 1.1 | 0–1 | 1.1 | Benevento | 4,130 | Stadio Renato Curi | Eugenio Abbattista | Match Report | |
| 26 | Sun | 2022-02-27 | 15:30 | Cittadella | 1.2 | 3–0 | 0.6 | Frosinone | 1,294 | Stadio Pier Cesare Tombolato | Alberto Santoro | Match Report | |
| 26 | Sun | 2022-02-27 | 15:30 | Ascoli | 1.6 | 2–1 | 0.8 | Crotone | 2,720 | Stadio Cino e Lillo Del Duca | Niccolò Baroni | Match Report | |
| 26 | Sun | 2022-02-27 | 15:30 | Monza | 1.0 | 0–1 | 1.2 | Lecce | 6,858 | U-Power Stadium | Daniele Doveri | Match Report | |
| 26 | Sun | 2022-02-27 | 15:30 | US Reggina | 0.7 | 1–0 | 1.4 | Pisa | 3,597 | Stadio Oreste Granillo | Luca Massimi | Match Report | |
| 27 | Tue | 2022-03-01 | 18:30 | Ternana | 0.5 | 1–0 | 1.0 | Pordenone | 1,163 | Stadio Libero Liberati | Davide Ghersini | Match Report | |
| 27 | Tue | 2022-03-01 | 18:30 | Benevento | 0.7 | 1–1 | 2.1 | Cremonese | 3,099 | Stadio Ciro Vigorito | Daniele Minelli | Match Report | |
| 27 | Tue | 2022-03-01 | 18:30 | Brescia | 2.8 | 2–1 | 0.6 | Perugia | 2,924 | Stadio Mario Rigamonti | Gianpiero Miele | Match Report | |
| 27 | Tue | 2022-03-01 | 20:30 | Alessandria | 2.7 | 1–1 | 1.1 | Como | 1,857 | Stadio Giuseppe Moccagatta | Francesco Meraviglia | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | Monza | 1.5 | 1–1 | 0.2 | Parma | 3,789 | U-Power Stadium | Paolo Valeri | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | Frosinone | 1.7 | 1–0 | 0.4 | Cosenza | 4,115 | Stadio Benito Stirpe | Lorenzo Maggioni | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | US Reggina | 1.6 | 3–1 | 2.0 | Vicenza Virtus | 3,401 | Stadio Oreste Granillo | Antonio Di Martino | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | Pisa | 2.7 | 3–2 | 0.6 | Crotone | 3,623 | Arena Garibaldi - Stadio Romeo Anconetan... | Cosso Cosso | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | SPAL | 1.0 | 0–0 | 0.5 | Cittadella | 4,132 | Stadio Paolo Mazza | Ivan Pezzuto | Match Report | |
| 27 | Wed | 2022-03-02 | 18:30 | Lecce | 2.8 | 3–1 | 0.9 | Ascoli | 5,359 | Stadio Comunale Via Del Mare | Rosario Abisso | Match Report | |
| 28 | Sat | 2022-03-05 | 14:00 | Como | 0.4 | 0–2 | 2.7 | SPAL | 2,317 | Stadio Giuseppe Sinigaglia | Matteo Gariglio | Match Report | |
| 28 | Sat | 2022-03-05 | 14:00 | Parma | 1.1 | 1–1 | 0.4 | US Reggina | 6,125 | Stadio Ennio Tardini | Eugenio Abbattista | Match Report | |
| 28 | Sat | 2022-03-05 | 14:00 | Pordenone | 0.6 | 0–1 | 1.2 | Pisa | 717 | Stadio Comunale G.Teghil | Matteo Marcenaro | Match Report | |
| 28 | Sat | 2022-03-05 | 14:00 | Cittadella | 1.8 | 1–2 | 1.3 | Monza | 1,657 | Stadio Pier Cesare Tombolato | Marco Piccinini | Match Report | |
| 28 | Sat | 2022-03-05 | 16:15 | Cremonese | 1.1 | 2–1 | 0.4 | Brescia | 9,098 | Stadio Giovanni Zini | Giovanni Ayroldi | Match Report | |
| 28 | Sun | 2022-03-06 | 15:30 | Perugia | 0.9 | 1–1 | 2.1 | Lecce | 4,663 | Stadio Renato Curi | Alberto Santoro | Match Report | |
| 28 | Sun | 2022-03-06 | 15:30 | Vicenza Virtus | 1.9 | 3–1 | 1.1 | Ternana | 5,062 | Stadio Romeo Menti | Juan Sacchi | Match Report | |
| 28 | Sun | 2022-03-06 | 15:30 | Crotone | 1.4 | 0–0 | 0.4 | Alessandria | 1,918 | Stadio Ezio Scida | Valerio Marini | Match Report | |
| 28 | Sun | 2022-03-06 | 15:30 | Ascoli | 0.9 | 1–1 | 0.8 | Frosinone | 3,901 | Stadio Cino e Lillo Del Duca | Marco Serra | Match Report | |
| 29 | Fri | 2022-03-11 | 20:30 | Parma | 2.0 | 1–1 | 0.9 | Cittadella | 4,733 | Stadio Ennio Tardini | Matteo Marchetti | Match Report | |
| 29 | Sat | 2022-03-12 | 14:00 | Lecce | 1.0 | 1–1 | 1.3 | Brescia | 12,316 | Stadio Comunale Via Del Mare | Michael Fabbri | Match Report | |
| 29 | Sat | 2022-03-12 | 14:00 | Ternana | 0.9 | 2–0 | 1.5 | Cosenza | 2,698 | Stadio Libero Liberati | Niccolò Baroni | Match Report | |
| 29 | Sat | 2022-03-12 | 14:00 | US Reggina | 0.9 | 0–1 | 0.7 | Perugia | 3,956 | Stadio Oreste Granillo | Antonio Rapuano | Match Report | |
| 29 | Sat | 2022-03-12 | 16:15 | Frosinone | 2.0 | 3–0 | 1.1 | Alessandria | 4,205 | Stadio Benito Stirpe | Andrea Colombo | Match Report | |
| 29 | Sat | 2022-03-12 | 16:15 | SPAL | 0.4 | 1–2 | 1.3 | Ascoli | 4,688 | Stadio Paolo Mazza | Daniele Paterna | Match Report | |
| 29 | Sat | 2022-03-12 | 16:15 | Pordenone | 1.4 | 1–1 | 1.6 | Como | 678 | Stadio Comunale G.Teghil | Gianpiero Miele | Match Report | |
| 29 | Sat | 2022-03-12 | 16:15 | Benevento | 2.2 | 3–1 | 0.4 | Crotone | 2,936 | Stadio Ciro Vigorito | Antonio Giua | Match Report | |
| 29 | Sat | 2022-03-12 | 16:15 | Monza | 3.0 | 4–0 | 0.2 | Vicenza Virtus | 3,524 | U-Power Stadium | Daniele Minelli | Match Report | |
| 29 | Sun | 2022-03-13 | 15:30 | Pisa | 2.5 | 3–0 | 1.7 | Cremonese | 7,374 | Arena Garibaldi - Stadio Romeo Anconetan... | Alessandro Prontera | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Vicenza Virtus | 0.9 | 0–1 | 1.3 | Parma | 5,859 | Stadio Romeo Menti | Ivan Pezzuto | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Cittadella | 0.9 | 0–0 | 0.5 | US Reggina | 1,105 | Stadio Pier Cesare Tombolato | Lorenzo Maggioni | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Crotone | 1.8 | 2–0 | 1.1 | Frosinone | 1,311 | Stadio Ezio Scida | Matteo Gariglio | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Brescia | 2.0 | 2–2 | 0.5 | Benevento | 3,729 | Stadio Mario Rigamonti | Marco Piccinini | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Cosenza | 1.0 | 2–2 | 1.9 | Lecce | 2,477 | Stadio San Vito | Livio Marinelli | Match Report | |
| 30 | Tue | 2022-03-15 | 18:30 | Como | 0.6 | 1–1 | 2.2 | Ternana | 1,476 | Stadio Giuseppe Sinigaglia | Cosso Cosso | Match Report | |
| 30 | Tue | 2022-03-15 | 20:30 | Alessandria | 0.2 | 0–3 | 1.0 | Monza | 2,050 | Stadio Giuseppe Moccagatta | Giacomo Camplone | Match Report | |
| 30 | Wed | 2022-03-16 | 18:30 | Ascoli | 1.6 | 2–0 | 0.7 | Pisa | 4,027 | Stadio Cino e Lillo Del Duca | Valerio Marini | Match Report | |
| 30 | Wed | 2022-03-16 | 18:30 | Perugia | 1.3 | 1–1 | 0.4 | SPAL | 3,009 | Stadio Renato Curi | Antonio Di Martino | Match Report | |
| 30 | Wed | 2022-03-16 | 18:30 | Cremonese | 0.9 | 2–1 | 0.8 | Pordenone | 3,474 | Stadio Giovanni Zini | Francesco Meraviglia | Match Report | |
| 31 | Sat | 2022-03-19 | 14:00 | US Reggina | 1.2 | 1–0 | 1.2 | Cosenza | 4,932 | Stadio Oreste Granillo | Antonio Giua | Match Report | |
| 31 | Sat | 2022-03-19 | 14:00 | Parma | 0.8 | 0–0 | 1.0 | Lecce | 7,916 | Stadio Ennio Tardini | Antonio Rapuano | Match Report | |
| 31 | Sat | 2022-03-19 | 14:00 | Monza | 1.0 | 1–0 | 0.6 | Crotone | 3,601 | U-Power Stadium | Daniele Paterna | Match Report | |
| 31 | Sat | 2022-03-19 | 14:00 | Ternana | 1.1 | 3–0 | 0.6 | Alessandria | 2,538 | Stadio Libero Liberati | Eugenio Abbattista | Match Report | |
| 31 | Sat | 2022-03-19 | 16:15 | Frosinone | 1.6 | 2–0 | 0.5 | Benevento | 5,372 | Stadio Benito Stirpe | Davide Ghersini | Match Report | |
| 31 | Sun | 2022-03-20 | 14:00 | Pisa | 0.9 | 1–0 | 0.3 | Cittadella | 5,441 | Arena Garibaldi - Stadio Romeo Anconetan... | Gianluca Aureliano | Match Report | |
| 31 | Sun | 2022-03-20 | 14:00 | Perugia | 1.3 | 0–1 | 0.5 | Como | 3,406 | Stadio Renato Curi | Marco Serra | Match Report | |
| 31 | Sun | 2022-03-20 | 14:00 | Vicenza Virtus | 1.7 | 2–0 | 0.6 | Ascoli | 5,041 | Stadio Romeo Menti | Alberto Santoro | Match Report | |
| 31 | Sun | 2022-03-20 | 16:15 | Pordenone | 1.6 | 1–1 | 1.5 | Brescia | 1,008 | Stadio Comunale G.Teghil | Niccolò Baroni | Match Report | |
| 31 | Sun | 2022-03-20 | 16:15 | SPAL | 1.1 | 0–2 | 1.5 | Cremonese | 4,961 | Stadio Paolo Mazza | Luca Pairetto | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Lecce | 0.9 | 1–0 | 0.1 | Frosinone | 9,327 | Stadio Comunale Via Del Mare | Marco Guida | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Ascoli | 0.9 | 1–0 | 0.2 | Pordenone | 3,564 | Stadio Cino e Lillo Del Duca | Cosso Cosso | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Cittadella | 0.7 | 1–2 | 1.4 | Ternana | 1,185 | Stadio Pier Cesare Tombolato | Gianpiero Miele | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Cosenza | 2.3 | 1–3 | 0.7 | Parma | 2,252 | Stadio San Vito | Valerio Marini | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Cremonese | 0.9 | 1–1 | 1.6 | US Reggina | 7,255 | Stadio Giovanni Zini | Eugenio Abbattista | Match Report | |
| 32 | Sat | 2022-04-02 | 14:00 | Alessandria | 1.7 | 2–2 | 1.6 | SPAL | 3,198 | Stadio Giuseppe Moccagatta | Simone Sozza | Match Report | |
| 32 | Sat | 2022-04-02 | 16:15 | Benevento | 2.0 | 5–1 | 1.2 | Pisa | 3,409 | Stadio Ciro Vigorito | Antonio Di Martino | Match Report | |
| 32 | Sun | 2022-04-03 | 15:30 | Como | 0.6 | 2–0 | 1.2 | Monza | 4,904 | Stadio Giuseppe Sinigaglia | Alessandro Prontera | Match Report | |
| 32 | Sun | 2022-04-03 | 15:30 | Brescia | 2.5 | 2–0 | 0.4 | Vicenza Virtus | 5,439 | Stadio Mario Rigamonti | Matteo Gariglio | Match Report | |
| 32 | Sun | 2022-04-03 | 15:30 | Crotone | 1.6 | 1–1 | 1.1 | Perugia | 1,877 | Stadio Ezio Scida | Giacomo Camplone | Match Report | |
| 33 | Tue | 2022-04-05 | 19:00 | US Reggina | 0.6 | 0–3 | 1.4 | Benevento | 4,237 | Stadio Oreste Granillo | Andrea Colombo | Match Report | |
| 33 | Tue | 2022-04-05 | 19:00 | Pordenone | 2.0 | 2–0 | 1.5 | Frosinone | 456 | Stadio Comunale G.Teghil | Marco Serra | Match Report | |
| 33 | Tue | 2022-04-05 | 19:00 | SPAL | 1.5 | 2–2 | 1.3 | Cosenza | 4,338 | Stadio Paolo Mazza | Daniele Minelli | Match Report | |
| 33 | Tue | 2022-04-05 | 19:00 | Cremonese | 1.8 | 2–1 | 0.9 | Alessandria | 6,311 | Stadio Giovanni Zini | Ivan Pezzuto | Match Report | |
| 33 | Tue | 2022-04-05 | 19:00 | Ternana | 1.0 | 1–4 | 0.9 | Lecce | 3,827 | Stadio Libero Liberati | Matteo Marcenaro | Match Report | |
| 33 | Wed | 2022-04-06 | 14:00 | Parma | 1.4 | 4–3 | 2.3 | Como | 5,310 | Stadio Ennio Tardini | Francesco Meraviglia | Match Report | |
| 33 | Wed | 2022-04-06 | 19:00 | Vicenza Virtus | 1.5 | 1–1 | 0.6 | Crotone | 5,259 | Stadio Romeo Menti | Niccolò Baroni | Match Report | |
| 33 | Wed | 2022-04-06 | 19:00 | Cittadella | 1.1 | 0–0 | 0.6 | Perugia | 1,191 | Stadio Pier Cesare Tombolato | Ivan Robilotta | Match Report | |
| 33 | Wed | 2022-04-06 | 19:00 | Pisa | 0.5 | 0–0 | 1.2 | Brescia | 7,271 | Arena Garibaldi - Stadio Romeo Anconetan... | Alberto Santoro | Match Report | |
| 33 | Wed | 2022-04-06 | 19:00 | Monza | 1.5 | 2–0 | 1.2 | Ascoli | 4,633 | U-Power Stadium | Matteo Gariglio | Match Report | |
| 34 | Sat | 2022-04-09 | 14:00 | Como | 0.7 | 1–2 | 0.9 | Cittadella | 1,999 | Stadio Giuseppe Sinigaglia | Daniele Paterna | Match Report | |
| 34 | Sat | 2022-04-09 | 14:00 | Alessandria | 1.2 | 2–0 | 0.3 | Pordenone | 2,330 | Stadio Giuseppe Moccagatta | Valerio Marini | Match Report | |
| 34 | Sat | 2022-04-09 | 14:00 | Lecce | 1.8 | 1–0 | 0.9 | SPAL | 11,578 | Stadio Comunale Via Del Mare | Matteo Marchetti | Match Report | |
| 34 | Sat | 2022-04-09 | 16:15 | Frosinone | 1.8 | 2–1 | 1.1 | Cremonese | 5,067 | Stadio Benito Stirpe | Rosario Abisso | Match Report | |
| 34 | Sun | 2022-04-10 | 14:30 | Benevento | 1.0 | 1–0 | 0.2 | Vicenza Virtus | 3,214 | Stadio Ciro Vigorito | Lorenzo Maggioni | Match Report | |
| 34 | Sun | 2022-04-10 | 15:30 | Crotone | 0.7 | 1–2 | 1.0 | Ternana | 2,024 | Stadio Ezio Scida | Eugenio Abbattista | Match Report | |
| 34 | Sun | 2022-04-10 | 15:30 | Ascoli | 1.8 | 2–0 | 0.2 | US Reggina | 4,891 | Stadio Cino e Lillo Del Duca | Antonio Di Martino | Match Report | |
| 34 | Sun | 2022-04-10 | 15:30 | Cosenza | 0.6 | 0–2 | 2.5 | Monza | 2,592 | Stadio San Vito | Fabio Maresca | Match Report | |
| 34 | Sun | 2022-04-10 | 18:00 | Perugia | 2.6 | 1–1 | 1.2 | Pisa | 5,042 | Stadio Renato Curi | Davide Massa | Match Report | |
| 34 | Mon | 2022-04-11 | 20:30 | Brescia | 0.7 | 1–0 | 0.8 | Parma | 6,715 | Stadio Mario Rigamonti | Davide Ghersini | Match Report | |
| 28 | Thu | 2022-04-14 | 20:00 | Cosenza | 0.5 | 1–0 | 1.8 | Benevento | 3,001 | Stadio San Vito | Antonio Rapuano | Match Report | |
| 35 | Mon | 2022-04-18 | 12:30 | SPAL | 1.4 | 1–1 | 1.6 | Crotone | 4,110 | Stadio Paolo Mazza | Massimiliano Irrati | Match Report | |
| 35 | Mon | 2022-04-18 | 15:00 | Cremonese | 1.0 | 3–1 | 1.5 | Cosenza | 6,287 | Stadio Giovanni Zini | Francesco Meraviglia | Match Report | |
| 35 | Mon | 2022-04-18 | 15:00 | Pordenone | 0.6 | 1–4 | 2.6 | Benevento | 718 | Stadio Comunale G.Teghil | Giacomo Camplone | Match Report | |
| 35 | Mon | 2022-04-18 | 15:00 | Vicenza Virtus | 1.1 | 1–2 | 0.2 | Perugia | 5,307 | Stadio Romeo Menti | Giovanni Ayroldi | Match Report | |
| 35 | Mon | 2022-04-18 | 15:00 | US Reggina | 1.4 | 1–0 | 0.9 | Lecce | 3,682 | Stadio Oreste Granillo | Francesco Fourneau | Match Report | |
| 35 | Mon | 2022-04-18 | 18:00 | Pisa | 2.3 | 3–1 | 1.3 | Como | 6,218 | Arena Garibaldi - Stadio Romeo Anconetan... | Ivan Pezzuto | Match Report | |
| 35 | Mon | 2022-04-18 | 18:00 | Cittadella | 1.1 | 1–2 | 1.6 | Alessandria | 1,497 | Stadio Pier Cesare Tombolato | Antonio Giua | Match Report | |
| 35 | Mon | 2022-04-18 | 18:00 | Ternana | 1.0 | 4–4 | 2.2 | Frosinone | 3,605 | Stadio Libero Liberati | Ivan Robilotta | Match Report | |
| 35 | Mon | 2022-04-18 | 18:00 | Parma | 1.4 | 0–1 | 0.7 | Ascoli | 7,309 | Stadio Ennio Tardini | Matteo Marcenaro | Match Report | |
| 35 | Mon | 2022-04-18 | 20:30 | Monza | 1.0 | 1–1 | 1.8 | Brescia | 7,504 | U-Power Stadium | Livio Marinelli | Match Report | |
| 36 | Mon | 2022-04-25 | 12:30 | Ascoli | 1.3 | 0–0 | 0.8 | Cittadella | 6,164 | Stadio Cino e Lillo Del Duca | Daniele Minelli | Match Report | |
| 36 | Mon | 2022-04-25 | 15:00 | Alessandria | 0.9 | 0–0 | 0.3 | US Reggina | 4,783 | Stadio Giuseppe Moccagatta | Matteo Gariglio | Match Report | |
| 36 | Mon | 2022-04-25 | 15:00 | Crotone | 0.9 | 3–1 | 1.1 | Cremonese | 1,546 | Stadio Ezio Scida | Michael Fabbri | Match Report | |
| 36 | Mon | 2022-04-25 | 15:00 | Lecce | 2.1 | 2–0 | 0.3 | Pisa | 23,933 | Stadio Comunale Via Del Mare | Luca Pairetto | Match Report | |
| 36 | Mon | 2022-04-25 | 15:00 | Frosinone | 1.0 | 4–1 | 0.7 | Monza | 6,631 | Stadio Benito Stirpe | Daniele Chiffi | Match Report | |
| 36 | Mon | 2022-04-25 | 15:00 | Cosenza | 2.2 | 3–1 | 1.5 | Pordenone | 5,824 | Stadio San Vito | Luca Massimi | Match Report | |
| 36 | Mon | 2022-04-25 | 18:00 | Como | 1.5 | 0–2 | 1.5 | Vicenza Virtus | 2,491 | Stadio Giuseppe Sinigaglia | Marco Serra | Match Report | |
| 36 | Mon | 2022-04-25 | 18:00 | Benevento | 1.7 | 1–2 | 2.4 | Ternana | 6,823 | Stadio Ciro Vigorito | Niccolò Baroni | Match Report | |
| 36 | Mon | 2022-04-25 | 18:00 | Brescia | 1.2 | 1–1 | 0.9 | SPAL | 8,710 | Stadio Mario Rigamonti | Antonio Rapuano | Match Report | |
| 36 | Mon | 2022-04-25 | 20:30 | Perugia | 3.1 | 2–1 | 1.4 | Parma | 4,750 | Stadio Renato Curi | Antonio Di Martino | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Pordenone | 2.3 | 3–3 | 3.1 | Crotone | 615 | Stadio Comunale G.Teghil | Gianpiero Miele | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Pisa | 1.0 | 1–1 | 1.3 | Cosenza | 7,674 | Arena Garibaldi - Stadio Romeo Anconetan... | Eugenio Abbattista | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Monza | 2.5 | 3–0 | 0.5 | Benevento | 8,402 | U-Power Stadium | Marco Di Bello | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Ternana | 2.3 | 1–0 | 0.9 | Perugia | 10,354 | Stadio Libero Liberati | Davide Massa | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Cremonese | 0.5 | 0–1 | 0.7 | Ascoli | 12,119 | Stadio Giovanni Zini | Gianluca Manganiello | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | SPAL | 0.8 | 3–0 | 0.9 | Frosinone | 7,033 | Stadio Paolo Mazza | Gianluca Aureliano | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Vicenza Virtus | 1.2 | 2–1 | 0.8 | Lecce | 10,019 | Stadio Romeo Menti | Maurizio Mariani | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Cittadella | 0.6 | 1–0 | 1.0 | Brescia | 2,454 | Stadio Pier Cesare Tombolato | Valerio Marini | Match Report | |
| 37 | Sat | 2022-04-30 | 14:00 | Parma | 0.8 | 2–2 | 0.8 | Alessandria | 6,566 | Stadio Ennio Tardini | Daniele Paterna | Match Report | |
| 37 | Sat | 2022-04-30 | 16:15 | US Reggina | 0.8 | 1–4 | 1.9 | Como | 3,832 | Stadio Oreste Granillo | Ivan Robilotta | Match Report | |
| 38 | Fri | 2022-05-06 | 18:15 | Crotone | 0.7 | 0–1 | 0.7 | Parma | 1,362 | Stadio Ezio Scida | Andrea Colombo | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Perugia | 1.9 | 1–0 | 1.7 | Monza | 6,828 | Stadio Renato Curi | Michael Fabbri | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Frosinone | 0.8 | 1–2 | 0.6 | Pisa | 8,927 | Stadio Benito Stirpe | Antonio Rapuano | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Como | 1.4 | 1–2 | 2.0 | Cremonese | 11,454 | Stadio Giuseppe Sinigaglia | Gianluca Aureliano | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Benevento | 1.9 | 1–2 | 2.4 | SPAL | 5,155 | Stadio Ciro Vigorito | Antonio Giua | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Cosenza | 0.4 | 1–0 | 0.3 | Cittadella | 11,454 | Stadio San Vito | Davide Ghersini | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Brescia | 2.6 | 3–0 | 0.4 | US Reggina | 3,742 | Stadio Mario Rigamonti | Matteo Marchetti | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Lecce | 3.1 | 1–0 | 0.1 | Pordenone | 26,904 | Stadio Comunale Via Del Mare | Marco Piccinini | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Ascoli | 2.5 | 4–1 | 0.9 | Ternana | 7,651 | Stadio Cino e Lillo Del Duca | Lorenzo Maggioni | Match Report | |
| 38 | Fri | 2022-05-06 | 20:30 | Alessandria | 0.6 | 0–1 | 0.6 | Vicenza Virtus | 4,838 | Stadio Giuseppe Moccagatta | Daniele Chiffi | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Preliminary round | Fri | 2022-05-13 | 20:30 | Ascoli | 0.9 | 0–1 | 0.4 | Benevento | 10,797 | Stadio Cino e Lillo Del Duca | Gianluca Manganiello | Match Report | |
| Preliminary round | Sat | 2022-05-14 | 18:00 | Brescia | 2.7 | 3–2 | 1.0 | Perugia | 10,740 | Stadio Mario Rigamonti | Francesco Fourneau | Match Report | Required Extra Time |
| Semi-finals | Tue | 2022-05-17 | 20:30 | Benevento | 1.7 | 1–0 | 0.7 | Pisa | 10,979 | Stadio Ciro Vigorito | Alessandro Prontera | Match Report | Leg 1 of 2 |
| Semi-finals | Wed | 2022-05-18 | 20:00 | Brescia | 1.3 | 1–2 | 2.5 | Monza | 13,600 | Stadio Mario Rigamonti | Gianluca Aureliano | Match Report | Leg 1 of 2 |
| Semi-finals | Sat | 2022-05-21 | 18:00 | Pisa | 1.0 | 1–0 | 0.2 | Benevento | 9,942 | Arena Garibaldi - Stadio Romeo Anconetan... | Simone Sozza | Match Report | Leg 2 of 2; Pisa won |
| Semi-finals | Sun | 2022-05-22 | 21:00 | Monza | 1.6 | 2–1 | 1.0 | Brescia | 8,559 | U-Power Stadium | Paolo Valeri | Match Report | Leg 2 of 2; Monza won |
| Finals | Thu | 2022-05-26 | 20:30 | Monza | 1.6 | 2–1 | 1.6 | Pisa | 9,649 | U-Power Stadium | Marco Guida | Match Report | Leg 1 of 2 |
| Finals | Sun | 2022-05-29 | 20:30 | Pisa | 1.4 | 3–4 | 2.4 | Monza | 9,500 | Arena Garibaldi - Stadio Romeo Anconetan... | Maurizio Mariani | Match Report | Leg 2 of 2; Monza won |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thu | 2022-05-12 | 20:30 | Vicenza Virtus | 2.3 | 1–0 | 0.6 | Cosenza | 10,659 | Stadio Romeo Menti | Fabio Maresca | Match Report | Leg 1 of 2 |
| Fri | 2022-05-20 | 20:30 | Cosenza | 1.7 | 2–0 | 0.7 | Vicenza Virtus | 17,771 | Stadio San Vito | Davide Massa | Match Report | Leg 2 of 2; Cosenza won |
About FBref.com
FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
FBref is the most complete sources for women's football data on the internet. This includes the entire history of the FIFA Women's World Cup as well as recent domestic league seasons from nine countries, including advanced stats like xG for most of those nine.
In collaboration with Opta, we are including advanced analytical data such as xG, xA, progressive passing, duels and more for over twenty competitions. For more information on the expected goals model and which competitions have advanced data, see our xG explainer.
Note that player records are likely not complete for their careers. Players may come from or move to leagues we don't currently cover. This issue will go down over time, as we add new leagues and seasons. We will never in the future have less data than we do today.
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