Scores & Fixtures 2021-2022 Segunda División
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Regular season | 1 | Fri | 2021-08-13 | 20:00 | Huesca | 0.5 | 2–0 | 0.8 | Eibar | 2,944 | Estadio El Alcoraz | José López | Match Report | |
| Regular season | 1 | Fri | 2021-08-13 | 22:00 | Zaragoza | 0.5 | 0–0 | 0.6 | Ibiza | 6,745 | Estadio de la Romareda | Iosu Galech | Match Report | |
| Regular season | 1 | Sat | 2021-08-14 | 17:00 | Real Sociedad B | 1.0 | 1–0 | 0.8 | Leganés | 2,597 | Estadio Municipal de Anoeta | Víctor García Verdura | Match Report | |
| Regular season | 1 | Sat | 2021-08-14 | 19:30 | Girona | 1.5 | 2–0 | 0.5 | Amorebieta | 1,817 | Estadi Municipal de Montilivi | David Gálvez | Match Report | |
| Regular season | 1 | Sat | 2021-08-14 | 22:00 | Ponferradina | 1.5 | 1–0 | 0.7 | Alcorcón | 2,743 | Estadio El Toralín | Javier Villanueva | Match Report | |
| Regular season | 1 | Sun | 2021-08-15 | 17:00 | Sporting Gijón | 1.2 | 1–0 | 1.2 | Burgos | 10,170 | Estadio Municipal El Molinón | Gorka Sagues | Match Report | |
| Regular season | 1 | Sun | 2021-08-15 | 19:30 | Oviedo | 1.0 | 2–2 | 1.7 | Lugo | 5,769 | Estadio Carlos Tartiere | Alejandro Quintero | Match Report | |
| Regular season | 1 | Sun | 2021-08-15 | 21:00 | Las Palmas | 0.8 | 1–1 | 1.2 | Valladolid | 7,100 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| Regular season | 1 | Sun | 2021-08-15 | 22:00 | Fuenlabrada | 0.6 | 1–2 | 1.1 | Tenerife | 1,184 | Estadio Fernando Torres | Saúl Ais | Match Report | |
| Regular season | 1 | Mon | 2021-08-16 | 20:00 | Málaga | 1.5 | 0–0 | 0.4 | CD Mirandés | 6,519 | Estadio La Rosaleda | Juan Pulido | Match Report | |
| Regular season | 1 | Mon | 2021-08-16 | 22:00 | Cartagena | 0.9 | 1–3 | 2.0 | Almería | 4,770 | Estadio Municipal Cartagonova | Aitor Gorostegui | Match Report | |
| Regular season | 2 | Fri | 2021-08-20 | 20:00 | Valladolid | 0.9 | 2–0 | 1.8 | Zaragoza | 10,080 | Estadio Municipal José Zorrilla | Eduardo Prieto | Match Report | |
| Regular season | 2 | Fri | 2021-08-20 | 22:00 | Almería | 1.6 | 2–1 | 0.4 | Oviedo | 4,100 | Estadio de los Juegos Mediterráneos | Francisco Hernández | Match Report | |
| Regular season | 2 | Sat | 2021-08-21 | 17:00 | Lugo | 1.1 | 0–0 | 0.6 | Real Sociedad B | 1,657 | Estadio Anxo Carro | Raúl González | Match Report | |
| Regular season | 2 | Sat | 2021-08-21 | 18:30 | Tenerife | 1.2 | 0–0 | 0.2 | Sporting Gijón | 4,999 | Estadio Heliodoro Rodríguez Lopéz | Rubén Ávalos | Match Report | |
| Regular season | 2 | Sat | 2021-08-21 | 22:00 | Alcorcón | 1.4 | 0–2 | 1.4 | Fuenlabrada | 1,044 | Estadio Santo Domingo | Jon González | Match Report | |
| Regular season | 2 | Sun | 2021-08-22 | 17:00 | Ibiza | 1.0 | 2–2 | 1.0 | Málaga | 2,487 | Estadio Municipal de Can Misses | Oliver De La Fuente | Match Report | |
| Regular season | 2 | Sun | 2021-08-22 | 19:30 | Eibar | 1.7 | 0–1 | 0.5 | Ponferradina | 1,146 | Estadio Municipal de Ipurúa | Álvaro Moreno | Match Report | |
| Regular season | 2 | Sun | 2021-08-22 | 19:30 | Girona | 1.0 | 0–0 | 0.2 | Las Palmas | 2,163 | Estadi Municipal de Montilivi | Luis Milla | Match Report | |
| Regular season | 2 | Sun | 2021-08-22 | 22:00 | Huesca | 1.4 | 2–0 | 0.5 | Cartagena | 3,375 | Estadio El Alcoraz | Daniel Trujillo | Match Report | |
| Regular season | 2 | Mon | 2021-08-23 | 20:00 | CD Mirandés | 2.1 | 2–0 | 1.4 | Amorebieta | 2,054 | Estadio Municipal de Anduva | Iván Caparrós | Match Report | |
| Regular season | 2 | Mon | 2021-08-23 | 22:00 | Leganés | 1.8 | 0–0 | 0.3 | Burgos | 3,790 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| Regular season | 3 | Fri | 2021-08-27 | 19:00 | Las Palmas | 1.3 | 2–1 | 0.8 | Huesca | 9,840 | Estadio de Gran Canaria | Javier Villanueva | Match Report | |
| Regular season | 3 | Fri | 2021-08-27 | 22:00 | Málaga | 1.3 | 1–0 | 0.4 | Alcorcón | 6,884 | Estadio La Rosaleda | Aitor Gorostegui | Match Report | |
| Regular season | 3 | Sat | 2021-08-28 | 17:00 | Sporting Gijón | 1.5 | 2–1 | 0.8 | CD Mirandés | 10,240 | Estadio Municipal El Molinón | Dámaso Arcediano | Match Report | |
| Regular season | 3 | Sat | 2021-08-28 | 19:30 | Leganés | 1.4 | 1–2 | 0.9 | Ibiza | 4,454 | Estadio Municipal de Butarque | Alejandro Quintero | Match Report | |
| Regular season | 3 | Sat | 2021-08-28 | 19:30 | Oviedo | 0.8 | 0–0 | 0.4 | Tenerife | 6,381 | Estadio Carlos Tartiere | José López | Match Report | |
| Regular season | 3 | Sat | 2021-08-28 | 22:00 | Ponferradina | 0.7 | 2–1 | 1.3 | Girona | 3,397 | Estadio El Toralín | Juan Pulido | Match Report | |
| Regular season | 3 | Sun | 2021-08-29 | 17:00 | Amorebieta | 1.3 | 2–1 | 1.1 | Almería | 592 | Instalaciones de Lezama Campo 2 | Víctor García Verdura | Match Report | |
| Regular season | 3 | Sun | 2021-08-29 | 19:30 | Lugo | 1.2 | 0–2 | 0.4 | Valladolid | 1,856 | Estadio Anxo Carro | Gorka Sagues | Match Report | |
| Regular season | 3 | Sun | 2021-08-29 | 19:30 | Real Sociedad B | 1.7 | 0–0 | 0.1 | Fuenlabrada | 4,450 | Estadio Municipal de Anoeta | Iosu Galech | Match Report | |
| Regular season | 3 | Sun | 2021-08-29 | 22:00 | Burgos | 1.0 | 0–1 | 0.6 | Eibar | 4,373 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| Regular season | 3 | Mon | 2021-08-30 | 22:00 | Zaragoza | 0.5 | 0–1 | 0.6 | Cartagena | 10,704 | Estadio de la Romareda | Saúl Ais | Match Report | |
| Regular season | 4 | Fri | 2021-09-03 | 21:00 | Girona | 1.6 | 1–2 | 1.8 | Sporting Gijón | 2,141 | Estadi Municipal de Montilivi | Daniel Trujillo | Match Report | |
| Regular season | 4 | Sat | 2021-09-04 | 16:00 | Eibar | 1.6 | 1–1 | 0.6 | Leganés | 1,685 | Estadio Municipal de Ipurúa | Luis Milla | Match Report | |
| Regular season | 4 | Sat | 2021-09-04 | 17:15 | Tenerife | 1.1 | 2–0 | 0.8 | Ponferradina | 6,940 | Estadio Heliodoro Rodríguez Lopéz | Francisco Hernández | Match Report | |
| Regular season | 4 | Sat | 2021-09-04 | 18:15 | Cartagena | 1.2 | 1–0 | 1.1 | Real Sociedad B | 5,108 | Estadio Municipal Cartagonova | Iván Caparrós | Match Report | |
| Regular season | 4 | Sat | 2021-09-04 | 21:00 | Almería | 1.7 | 2–0 | 1.6 | Málaga | 6,353 | Estadio de los Juegos Mediterráneos | Jon González | Match Report | |
| Regular season | 4 | Sat | 2021-09-04 | 21:00 | Fuenlabrada | 1.5 | 1–1 | 0.4 | Lugo | 1,701 | Estadio Fernando Torres | Oliver De La Fuente | Match Report | |
| Regular season | 4 | Sun | 2021-09-05 | 16:00 | Burgos | 1.8 | 3–0 | 0.6 | Valladolid | 5,567 | Estadio Municipal de El Plantío | Álvaro Moreno | Match Report | |
| Regular season | 4 | Sun | 2021-09-05 | 16:00 | Ibiza | 2.6 | 1–1 | 0.7 | Amorebieta | 3,119 | Estadio Municipal de Can Misses | Raúl González | Match Report | |
| Regular season | 4 | Sun | 2021-09-05 | 18:15 | Alcorcón | 1.2 | 1–2 | 1.7 | Zaragoza | 1,744 | Estadio Santo Domingo | Rubén Ávalos | Match Report | |
| Regular season | 4 | Sun | 2021-09-05 | 18:15 | CD Mirandés | 2.1 | 4–2 | 1.3 | Las Palmas | 2,513 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| Regular season | 4 | Mon | 2021-09-06 | 21:00 | Huesca | 2.1 | 1–2 | 0.9 | Oviedo | 5,219 | Estadio El Alcoraz | Eduardo Prieto | Match Report | |
| Regular season | 5 | Fri | 2021-09-10 | 21:00 | Sporting Gijón | 2.2 | 2–1 | 0.8 | Leganés | 11,212 | Estadio Municipal El Molinón | Javier Villanueva | Match Report | |
| Regular season | 5 | Sat | 2021-09-11 | 16:00 | Amorebieta | 1.7 | 2–2 | 1.7 | Burgos | 832 | Instalaciones de Lezama Campo 2 | Alejandro Quintero | Match Report | |
| Regular season | 5 | Sat | 2021-09-11 | 16:00 | Real Sociedad B | 0.7 | 2–3 | 1.6 | Eibar | 6,266 | Estadio Municipal de Anoeta | Juan Pulido | Match Report | |
| Regular season | 5 | Sat | 2021-09-11 | 17:15 | Las Palmas | 0.9 | 1–1 | 0.7 | Ibiza | 11,726 | Estadio de Gran Canaria | Víctor García Verdura | Match Report | |
| Regular season | 5 | Sat | 2021-09-11 | 21:00 | CD Mirandés | 0.9 | 1–3 | 1.8 | Alcorcón | 2,356 | Estadio Municipal de Anduva | Gorka Sagues | Match Report | |
| Regular season | 5 | Sun | 2021-09-12 | 14:00 | Oviedo | 2.5 | 2–0 | 0.9 | Cartagena | 6,823 | Estadio Carlos Tartiere | Iosu Galech | Match Report | |
| Regular season | 5 | Sun | 2021-09-12 | 16:00 | Valladolid | 0.7 | 0–2 | 1.4 | Tenerife | 13,699 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| Regular season | 5 | Sun | 2021-09-12 | 18:15 | Ponferradina | 1.1 | 1–0 | 0.4 | Almería | 3,935 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| Regular season | 5 | Sun | 2021-09-12 | 20:30 | Fuenlabrada | 1.5 | 1–1 | 3.0 | Zaragoza | 2,240 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| Regular season | 5 | Sun | 2021-09-12 | 21:30 | Málaga | 2.0 | 2–0 | 0.7 | Girona | 11,108 | Estadio La Rosaleda | José López | Match Report | |
| Regular season | 5 | Mon | 2021-09-13 | 21:00 | Lugo | 2.8 | 3–2 | 0.5 | Huesca | 1,909 | Estadio Anxo Carro | Saúl Ais | Match Report | |
| Regular season | 6 | Fri | 2021-09-17 | 21:00 | Alcorcón | 1.1 | 0–4 | 3.1 | Almería | 1,559 | Estadio Santo Domingo | Raúl González | Match Report | |
| Regular season | 6 | Sat | 2021-09-18 | 16:00 | Ibiza | 0.8 | 1–1 | 1.8 | Oviedo | 3,119 | Estadio Municipal de Can Misses | Álvaro Moreno | Match Report | |
| Regular season | 6 | Sat | 2021-09-18 | 18:15 | Zaragoza | 2.1 | 1–1 | 0.5 | Real Sociedad B | 14,726 | Estadio de la Romareda | Oliver De La Fuente | Match Report | |
| Regular season | 6 | Sat | 2021-09-18 | 18:15 | Leganés | 1.2 | 1–0 | 0.9 | Amorebieta | 6,342 | Estadio Municipal de Butarque | Daniel Trujillo | Match Report | |
| Regular season | 6 | Sat | 2021-09-18 | 20:30 | Girona | 1.7 | 1–0 | 0.6 | Valladolid | 3,534 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| Regular season | 6 | Sat | 2021-09-18 | 21:00 | Cartagena | 1.8 | 2–1 | 0.7 | Lugo | 5,536 | Estadio Municipal Cartagonova | Eduardo Prieto | Match Report | |
| Regular season | 6 | Sun | 2021-09-19 | 14:00 | Huesca | 0.4 | 0–0 | 1.2 | Fuenlabrada | 5,183 | Estadio El Alcoraz | Dámaso Arcediano | Match Report | |
| Regular season | 6 | Sun | 2021-09-19 | 16:00 | Ponferradina | 2.4 | 4–0 | 0.9 | Málaga | 3,993 | Estadio El Toralín | Rafael Sánchez | Match Report | |
| Regular season | 6 | Sun | 2021-09-19 | 17:15 | Tenerife | 2.1 | 1–2 | 1.4 | CD Mirandés | 9,957 | Estadio Heliodoro Rodríguez Lopéz | Luis Milla | Match Report | |
| Regular season | 6 | Sun | 2021-09-19 | 18:15 | Eibar | 1.3 | 3–2 | 0.9 | Sporting Gijón | 2,462 | Estadio Municipal de Ipurúa | Francisco Hernández | Match Report | |
| Regular season | 6 | Mon | 2021-09-20 | 21:00 | Burgos | 0.5 | 0–0 | 1.2 | Las Palmas | 5,437 | Estadio Municipal de El Plantío | Iván Caparrós | Match Report | |
| Regular season | 7 | Fri | 2021-09-24 | 20:00 | Real Sociedad B | 1.4 | 0–2 | 2.2 | Huesca | 3,171 | Estadio Municipal de Anoeta | José López | Match Report | |
| Regular season | 7 | Fri | 2021-09-24 | 21:00 | Almería | 2.2 | 3–1 | 1.6 | Tenerife | 7,074 | Estadio de los Juegos Mediterráneos | Rubén Ávalos | Match Report | |
| Regular season | 7 | Sat | 2021-09-25 | 16:00 | Ibiza | 1.6 | 2–0 | 1.1 | Burgos | 3,742 | Estadio Municipal de Can Misses | Aitor Gorostegui | Match Report | |
| Regular season | 7 | Sat | 2021-09-25 | 17:15 | Las Palmas | 2.1 | 2–1 | 1.4 | Ponferradina | 10,210 | Estadio de Gran Canaria | Gorka Sagues | Match Report | |
| Regular season | 7 | Sat | 2021-09-25 | 18:15 | Amorebieta | 1.0 | 1–1 | 2.4 | Eibar | 1,236 | Instalaciones de Lezama Campo 2 | Javier Villanueva | Match Report | |
| Regular season | 7 | Sun | 2021-09-26 | 14:00 | CD Mirandés | 1.0 | 1–2 | 2.0 | Leganés | 2,399 | Estadio Municipal de Anduva | Francisco Hernández | Match Report | |
| Regular season | 7 | Sun | 2021-09-26 | 16:00 | Sporting Gijón | 2.3 | 2–1 | 0.2 | Málaga | 13,482 | Estadio Municipal El Molinón | Iosu Galech | Match Report | |
| Regular season | 7 | Sun | 2021-09-26 | 18:15 | Oviedo | 0.7 | 0–0 | 0.6 | Girona | 9,163 | Estadio Carlos Tartiere | David Gálvez | Match Report | |
| Regular season | 7 | Sun | 2021-09-26 | 20:30 | Lugo | 2.0 | 1–1 | 1.9 | Zaragoza | 2,135 | Estadio Anxo Carro | Víctor García Verdura | Match Report | |
| Regular season | 7 | Sun | 2021-09-26 | 21:00 | Valladolid | 1.8 | 2–0 | 0.6 | Alcorcón | 12,395 | Estadio Municipal José Zorrilla | Saúl Ais | Match Report | |
| Regular season | 7 | Mon | 2021-09-27 | 21:00 | Fuenlabrada | 1.5 | 2–1 | 1.5 | Cartagena | 2,109 | Estadio Fernando Torres | Alejandro Quintero | Match Report | |
| Regular season | 8 | Fri | 2021-10-01 | 21:00 | Ponferradina | 1.5 | 2–2 | 1.3 | Valladolid | 4,979 | Estadio El Toralín | José López | Match Report | |
| Regular season | 8 | Sat | 2021-10-02 | 16:00 | Amorebieta | 0.9 | 1–1 | 0.8 | Sporting Gijón | 1,178 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| Regular season | 8 | Sat | 2021-10-02 | 16:00 | Huesca | 1.0 | 1–2 | 1.0 | Tenerife | 6,826 | Estadio El Alcoraz | Jon González | Match Report | |
| Regular season | 8 | Sat | 2021-10-02 | 18:15 | Zaragoza | 1.4 | 0–0 | 0.4 | Oviedo | 16,889 | Estadio de la Romareda | Luis Milla | Match Report | |
| Regular season | 8 | Sat | 2021-10-02 | 21:00 | Alcorcón | 1.3 | 1–4 | 1.8 | Real Sociedad B | 1,357 | Estadio Santo Domingo | Rafael Sánchez | Match Report | |
| Regular season | 8 | Sun | 2021-10-03 | 14:00 | Eibar | 1.5 | 3–1 | 1.7 | Ibiza | 2,719 | Estadio Municipal de Ipurúa | Eduardo Prieto | Match Report | |
| Regular season | 8 | Sun | 2021-10-03 | 16:00 | Málaga | 0.8 | 1–0 | 0.9 | Fuenlabrada | 12,831 | Estadio La Rosaleda | Raúl González | Match Report | |
| Regular season | 8 | Sun | 2021-10-03 | 17:15 | Las Palmas | 3.8 | 4–1 | 0.9 | Cartagena | 11,873 | Estadio de Gran Canaria | Oliver De La Fuente | Match Report | |
| Regular season | 8 | Sun | 2021-10-03 | 18:15 | Burgos | 0.6 | 1–0 | 0.7 | CD Mirandés | 8,600 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report | |
| Regular season | 8 | Sun | 2021-10-03 | 21:00 | Leganés | 0.5 | 1–1 | 0.9 | Lugo | 6,131 | Estadio Municipal de Butarque | Iván Caparrós | Match Report | |
| Regular season | 8 | Mon | 2021-10-04 | 21:00 | Girona | 1.5 | 1–2 | 2.5 | Almería | 4,904 | Estadi Municipal de Montilivi | Juan Pulido | Match Report | |
| Regular season | 9 | Fri | 2021-10-08 | 21:00 | Valladolid | 2.0 | 1–1 | 1.1 | Málaga | 14,408 | Estadio Municipal José Zorrilla | Javier Villanueva | Match Report | |
| Regular season | 9 | Sat | 2021-10-09 | 16:00 | Lugo | 1.2 | 1–0 | 0.7 | Girona | 2,685 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| Regular season | 9 | Sat | 2021-10-09 | 16:00 | CD Mirandés | 1.7 | 3–3 | 3.5 | Eibar | 2,953 | Estadio Municipal de Anduva | Dámaso Arcediano | Match Report | |
| Regular season | 9 | Sat | 2021-10-09 | 18:15 | Almería | 1.7 | 1–1 | 0.7 | Las Palmas | 8,734 | Estadio de los Juegos Mediterráneos | Saúl Ais | Match Report | |
| Regular season | 9 | Sat | 2021-10-09 | 21:00 | Oviedo | 0.6 | 1–1 | 0.9 | Sporting Gijón | 21,053 | Estadio Carlos Tartiere | Rubén Ávalos | Match Report | |
| Regular season | 9 | Sun | 2021-10-10 | 14:00 | Real Sociedad B | 1.0 | 1–1 | 0.5 | Ponferradina | 972 | Estadio Municipal de Anoeta | Alejandro Quintero | Match Report | |
| Regular season | 9 | Sun | 2021-10-10 | 16:00 | Cartagena | 3.0 | 5–1 | 0.8 | Ibiza | 6,000 | Estadio Municipal Cartagonova | David Gálvez | Match Report | |
| Regular season | 9 | Sun | 2021-10-10 | 17:15 | Tenerife | 1.3 | 2–1 | 0.8 | Amorebieta | 12,572 | Estadio Heliodoro Rodríguez Lopéz | Víctor García Verdura | Match Report | |
| Regular season | 9 | Sun | 2021-10-10 | 18:15 | Alcorcón | 1.2 | 1–0 | 0.5 | Burgos | 1,953 | Estadio Santo Domingo | Iosu Galech | Match Report | |
| Regular season | 9 | Sun | 2021-10-10 | 18:15 | Fuenlabrada | 0.9 | 2–1 | 0.9 | Leganés | 3,244 | Estadio Fernando Torres | Gorka Sagues | Match Report | |
| Regular season | 9 | Mon | 2021-10-11 | 21:00 | Zaragoza | 1.3 | 0–0 | 0.8 | Huesca | 25,307 | Estadio de la Romareda | Francisco Hernández | Match Report | |
| Regular season | 10 | Fri | 2021-10-15 | 21:00 | Eibar | 1.0 | 1–0 | 1.4 | Almería | 3,630 | Estadio Municipal de Ipurúa | José López | Match Report | |
| Regular season | 10 | Sat | 2021-10-16 | 16:00 | Girona | 2.6 | 1–3 | 1.7 | Huesca | 6,101 | Estadi Municipal de Montilivi | Álvaro Moreno | Match Report | |
| Regular season | 10 | Sat | 2021-10-16 | 16:00 | Amorebieta | 1.7 | 2–3 | 1.1 | Cartagena | 878 | Instalaciones de Lezama Campo 2 | Juan Pulido | Match Report | |
| Regular season | 10 | Sat | 2021-10-16 | 17:15 | Las Palmas | 1.0 | 2–1 | 0.5 | Tenerife | 25,887 | Estadio de Gran Canaria | Eduardo Prieto | Match Report | |
| Regular season | 10 | Sat | 2021-10-16 | 20:30 | Málaga | 1.7 | 1–1 | 0.4 | Zaragoza | 15,901 | Estadio La Rosaleda | Jon González | Match Report | |
| Regular season | 10 | Sat | 2021-10-16 | 21:00 | Sporting Gijón | 3.2 | 1–0 | 0.4 | Alcorcón | 14,146 | Estadio Municipal El Molinón | Oliver De La Fuente | Match Report | |
| Regular season | 10 | Sun | 2021-10-17 | 14:00 | Ibiza | 1.6 | 0–2 | 0.8 | CD Mirandés | 3,217 | Estadio Municipal de Can Misses | Iván Caparrós | Match Report | |
| Regular season | 10 | Sun | 2021-10-17 | 16:00 | Leganés | 1.0 | 0–2 | 1.0 | Valladolid | 7,436 | Estadio Municipal de Butarque | Luis Milla | Match Report | |
| Regular season | 10 | Sun | 2021-10-17 | 18:15 | Burgos | 2.0 | 1–1 | 1.4 | Lugo | 6,352 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| Regular season | 10 | Sun | 2021-10-17 | 18:15 | Real Sociedad B | 0.8 | 1–1 | 1.9 | Oviedo | 3,028 | Estadio Municipal de Anoeta | Raúl González | Match Report | |
| Regular season | 10 | Sun | 2021-10-17 | 21:00 | Ponferradina | 1.4 | 0–0 | 0.4 | Fuenlabrada | 4,219 | Estadio El Toralín | Daniel Trujillo | Match Report | |
| Regular season | 11 | Tue | 2021-10-19 | 19:00 | Huesca | 0.8 | 0–0 | 0.7 | Málaga | 6,333 | Estadio El Alcoraz | David Gálvez | Match Report | |
| Regular season | 11 | Tue | 2021-10-19 | 19:00 | Cartagena | 2.2 | 1–0 | 0.6 | Sporting Gijón | 6,719 | Estadio Municipal Cartagonova | Saúl Ais | Match Report | |
| Regular season | 11 | Tue | 2021-10-19 | 20:00 | Tenerife | 0.6 | 0–1 | 0.5 | Eibar | 9,283 | Estadio Heliodoro Rodríguez Lopéz | Iosu Galech | Match Report | |
| Regular season | 11 | Wed | 2021-10-20 | 19:00 | Fuenlabrada | 0.5 | 0–0 | 0.8 | Amorebieta | 2,087 | Estadio Fernando Torres | Francisco Hernández | Match Report | |
| Regular season | 11 | Wed | 2021-10-20 | 19:00 | Valladolid | 2.4 | 1–1 | 0.9 | Ibiza | 12,991 | Estadio Municipal José Zorrilla | Gorka Sagues | Match Report | |
| Regular season | 11 | Wed | 2021-10-20 | 21:00 | Lugo | 0.3 | 2–0 | 0.6 | Las Palmas | 2,110 | Estadio Anxo Carro | Rubén Ávalos | Match Report | |
| Regular season | 11 | Wed | 2021-10-20 | 21:00 | Alcorcón | 1.1 | 3–3 | 3.1 | Leganés | 1,700 | Estadio Santo Domingo | Dámaso Arcediano | Match Report | |
| Regular season | 11 | Thu | 2021-10-21 | 18:45 | Almería | 3.2 | 3–1 | 0.6 | Real Sociedad B | 7,697 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| Regular season | 11 | Thu | 2021-10-21 | 19:00 | Zaragoza | 2.0 | 1–1 | 1.1 | Ponferradina | 15,676 | Estadio de la Romareda | Aitor Gorostegui | Match Report | |
| Regular season | 11 | Thu | 2021-10-21 | 21:00 | Oviedo | 2.0 | 1–3 | 0.9 | Burgos | 7,411 | Estadio Carlos Tartiere | Víctor García Verdura | Match Report | |
| Regular season | 11 | Thu | 2021-10-21 | 21:00 | CD Mirandés | 0.8 | 1–2 | 1.5 | Girona | 2,307 | Estadio Municipal de Anduva | Alejandro Quintero | Match Report | |
| Regular season | 12 | Fri | 2021-10-22 | 21:00 | Eibar | 1.9 | 2–1 | 0.7 | Cartagena | 21,128 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| Regular season | 12 | Sat | 2021-10-23 | 16:00 | Ibiza | 1.4 | 3–1 | 1.8 | Fuenlabrada | 3,419 | Estadio Municipal de Can Misses | Rafael Sánchez | Match Report | |
| Regular season | 12 | Sat | 2021-10-23 | 18:15 | Sporting Gijón | 1.9 | 1–2 | 0.8 | Valladolid | 16,541 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| Regular season | 12 | Sat | 2021-10-23 | 20:30 | Málaga | 1.7 | 1–0 | 0.5 | Lugo | 14,980 | Estadio La Rosaleda | Álvaro Moreno | Match Report | |
| Regular season | 12 | Sat | 2021-10-23 | 21:00 | Leganés | 0.8 | 1–2 | 1.0 | Tenerife | 6,454 | Estadio Municipal de Butarque | Oliver De La Fuente | Match Report | |
| Regular season | 12 | Sun | 2021-10-24 | 14:00 | CD Mirandés | 1.2 | 1–4 | 2.1 | Almería | 2,365 | Estadio Municipal de Anduva | Jon González | Match Report | |
| Regular season | 12 | Sun | 2021-10-24 | 14:00 | Amorebieta | 0.9 | 1–2 | 1.5 | Real Sociedad B | 996 | Instalaciones de Lezama Campo 2 | Daniel Trujillo | Match Report | |
| Regular season | 12 | Sun | 2021-10-24 | 18:15 | Burgos | 0.8 | 3–1 | 0.9 | Huesca | 6,145 | Estadio Municipal de El Plantío | Luis Milla | Match Report | |
| Regular season | 12 | Sun | 2021-10-24 | 18:15 | Ponferradina | 1.1 | 1–2 | 1.7 | Oviedo | 5,600 | Estadio El Toralín | Eduardo Prieto | Match Report | |
| Regular season | 12 | Sun | 2021-10-24 | 20:00 | Las Palmas | 2.2 | 3–0 | 0.2 | Alcorcón | 8,936 | Estadio de Gran Canaria | Iván Caparrós | Match Report | |
| Regular season | 12 | Mon | 2021-10-25 | 21:00 | Girona | 1.5 | 1–1 | 0.9 | Zaragoza | 5,162 | Estadi Municipal de Montilivi | Raúl González | Match Report | |
| Regular season | 13 | Fri | 2021-10-29 | 21:00 | Real Sociedad B | 1.2 | 0–1 | 1.1 | Las Palmas | 2,320 | Estadio Municipal de Anoeta | Dámaso Arcediano | Match Report | |
| Regular season | 13 | Fri | 2021-10-29 | 21:00 | Almería | 0.8 | 1–0 | 1.4 | Leganés | 8,867 | Estadio de los Juegos Mediterráneos | Iosu Galech | Match Report | |
| Regular season | 13 | Sat | 2021-10-30 | 16:00 | Huesca | 1.1 | 1–1 | 0.6 | Amorebieta | 6,016 | Estadio El Alcoraz | Alejandro Quintero | Match Report | |
| Regular season | 13 | Sat | 2021-10-30 | 18:15 | Lugo | 2.3 | 1–1 | 1.2 | Sporting Gijón | 5,069 | Estadio Anxo Carro | David Gálvez | Match Report | |
| Regular season | 13 | Sat | 2021-10-30 | 21:00 | Cartagena | 0.7 | 0–1 | 2.0 | Ponferradina | 6,242 | Estadio Municipal Cartagonova | Javier Villanueva | Match Report | |
| Regular season | 13 | Sun | 2021-10-31 | 14:00 | Fuenlabrada | 1.6 | 1–2 | 2.3 | Girona | 1,627 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| Regular season | 13 | Sun | 2021-10-31 | 16:00 | Oviedo | 1.4 | 2–1 | 0.9 | Málaga | 8,369 | Estadio Nuevo Carlos Tartiere | Saúl Ais | Match Report | |
| Regular season | 13 | Sun | 2021-10-31 | 18:15 | Valladolid | 1.3 | 2–0 | 1.6 | Eibar | 13,322 | Estadio Municipal José Zorrilla | Francisco Hernández | Match Report | |
| Regular season | 13 | Sun | 2021-10-31 | 20:30 | Zaragoza | 1.4 | 1–1 | 1.6 | CD Mirandés | 13,802 | Estadio de la Romareda | Gorka Sagues | Match Report | |
| Regular season | 13 | Mon | 2021-11-01 | 16:00 | Alcorcón | 0.3 | 0–2 | 0.9 | Ibiza | 1,522 | Estadio Santo Domingo | Víctor García Verdura | Match Report | |
| Regular season | 13 | Mon | 2021-11-01 | 17:15 | Tenerife | 3.0 | 4–0 | 0.6 | Burgos | 12,105 | Estadio Heliodoro Rodríguez Lopéz | José López | Match Report | |
| Regular season | 14 | Tue | 2021-11-02 | 19:00 | Sporting Gijón | 0.9 | 0–1 | 1.8 | Almería | 11,980 | Estadio Municipal El Molinón | Álvaro Moreno | Match Report | |
| Regular season | 14 | Tue | 2021-11-02 | 19:00 | Ponferradina | 1.2 | 1–1 | 1.0 | Huesca | 3,524 | Estadio El Toralín | Rubén Ávalos | Match Report | |
| Regular season | 14 | Tue | 2021-11-02 | 21:15 | Leganés | 1.7 | 1–1 | 0.9 | Cartagena | 4,767 | Estadio Municipal de Butarque | Eduardo Prieto | Match Report | |
| Regular season | 14 | Wed | 2021-11-03 | 19:00 | Amorebieta | 2.9 | 4–1 | 1.5 | Valladolid | 913 | Instalaciones de Lezama Campo 2 | Iván Caparrós | Match Report | |
| Regular season | 14 | Wed | 2021-11-03 | 19:00 | CD Mirandés | 2.3 | 3–2 | 1.2 | Lugo | 2,173 | Estadio Municipal de Anduva | Raúl González | Match Report | |
| Regular season | 14 | Wed | 2021-11-03 | 20:15 | Las Palmas | 2.4 | 2–1 | 0.9 | Fuenlabrada | 8,714 | Estadio de Gran Canaria | Luis Milla | Match Report | |
| Regular season | 14 | Wed | 2021-11-03 | 21:15 | Eibar | 0.6 | 1–0 | 0.5 | Oviedo | 3,551 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | |
| Regular season | 14 | Thu | 2021-11-04 | 19:00 | Girona | 1.8 | 3–1 | 1.6 | Alcorcón | 4,419 | Estadi Municipal de Montilivi | Rafael Sánchez | Match Report | |
| Regular season | 14 | Thu | 2021-11-04 | 19:00 | Burgos | 1.2 | 0–1 | 0.7 | Zaragoza | 9,584 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report | |
| Regular season | 14 | Thu | 2021-11-04 | 21:15 | Málaga | 1.1 | 2–1 | 1.4 | Real Sociedad B | 12,130 | Estadio La Rosaleda | Oliver De La Fuente | Match Report | |
| Regular season | 14 | Thu | 2021-11-04 | 21:15 | Ibiza | 0.5 | 0–0 | 0.8 | Tenerife | 3,501 | Estadio Municipal de Can Misses | Jon González | Match Report | |
| Regular season | 15 | Fri | 2021-11-05 | 21:00 | Huesca | 0.8 | 0–2 | 0.9 | Leganés | 5,504 | Estadio El Alcoraz | José López | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 16:00 | Lugo | 1.4 | 1–2 | 1.8 | Ponferradina | 2,828 | Estadio Anxo Carro | Alejandro Quintero | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 18:15 | Valladolid | 2.1 | 3–1 | 2.1 | CD Mirandés | 14,267 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 18:15 | Oviedo | 1.5 | 1–1 | 1.4 | Las Palmas | 9,139 | Estadio Carlos Tartiere | Francisco Hernández | Match Report | |
| Regular season | 15 | Sat | 2021-11-06 | 21:00 | Fuenlabrada | 1.1 | 0–0 | 1.1 | Eibar | 1,985 | Estadio Fernando Torres | Víctor García Verdura | Match Report | |
| Regular season | 15 | Sun | 2021-11-07 | 14:00 | Alcorcón | 1.8 | 2–2 | 0.2 | Amorebieta | 1,147 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| Regular season | 15 | Sun | 2021-11-07 | 16:00 | Zaragoza | 1.0 | 2–0 | 1.0 | Sporting Gijón | 18,100 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| Regular season | 15 | Sun | 2021-11-07 | 18:15 | Cartagena | 1.5 | 3–1 | 1.0 | Málaga | 7,591 | Estadio Municipal Cartagonova | Dámaso Arcediano | Match Report | |
| Regular season | 15 | Sun | 2021-11-07 | 18:15 | Almería | 1.3 | 2–0 | 0.2 | Burgos | 9,513 | Estadio de los Juegos Mediterráneos | Aitor Gorostegui | Match Report | |
| Regular season | 15 | Sun | 2021-11-07 | 21:00 | Real Sociedad B | 0.4 | 0–1 | 0.8 | Ibiza | 845 | Estadio Municipal de Anoeta | Iosu Galech | Match Report | |
| Regular season | 15 | Mon | 2021-11-08 | 20:00 | Tenerife | 0.8 | 2–1 | 0.9 | Girona | 10,121 | Estadio Heliodoro Rodríguez Lopéz | Gorka Sagues | Match Report | |
| Regular season | 16 | Fri | 2021-11-12 | 21:00 | Sporting Gijón | 1.1 | 0–1 | 1.3 | Real Sociedad B | 12,452 | Estadio Municipal El Molinón | Raúl González | Match Report | |
| Regular season | 16 | Sat | 2021-11-13 | 16:00 | Valladolid | 2.0 | 3–0 | 0.7 | Fuenlabrada | 14,105 | Estadio Municipal José Zorrilla | Rubén Ávalos | Match Report | |
| Regular season | 16 | Sat | 2021-11-13 | 18:15 | CD Mirandés | 0.8 | 0–1 | 1.6 | Huesca | 2,700 | Estadio Municipal de Anduva | Juan Pulido | Match Report | |
| Regular season | 16 | Sat | 2021-11-13 | 18:15 | Eibar | 1.2 | 2–1 | 1.7 | Alcorcón | 4,613 | Estadio Municipal de Ipurúa | Oliver De La Fuente | Match Report | |
| Regular season | 16 | Sat | 2021-11-13 | 19:30 | Las Palmas | 2.0 | 2–3 | 1.7 | Zaragoza | 13,432 | Estadio de Gran Canaria | Álvaro Moreno | Match Report | |
| Regular season | 16 | Sun | 2021-11-14 | 14:00 | Amorebieta | 0.6 | 1–3 | 0.4 | Lugo | 815 | Instalaciones de Lezama Campo 2 | Luis Milla | Match Report | |
| Regular season | 16 | Sun | 2021-11-14 | 16:00 | Ibiza | 1.1 | 0–1 | 2.1 | Almería | 4,937 | Estadio Municipal de Can Misses | Eduardo Prieto | Match Report | |
| Regular season | 16 | Sun | 2021-11-14 | 16:00 | Girona | 3.1 | 2–0 | 0.9 | Cartagena | 6,055 | Estadi Municipal de Montilivi | David Gálvez | Match Report | |
| Regular season | 16 | Sun | 2021-11-14 | 18:15 | Burgos | 0.8 | 1–0 | 1.5 | Ponferradina | 7,495 | Estadio Municipal de El Plantío | Iván Caparrós | Match Report | |
| Regular season | 16 | Sun | 2021-11-14 | 18:15 | Leganés | 1.0 | 0–0 | 0.5 | Oviedo | 7,803 | Estadio Municipal de Butarque | Javier Villanueva | Match Report | |
| Regular season | 16 | Mon | 2021-11-15 | 21:00 | Málaga | 1.3 | 1–0 | 1.1 | Tenerife | 15,700 | Estadio La Rosaleda | Rafael Sánchez | Match Report | |
| Regular season | 17 | Fri | 2021-11-19 | 21:00 | Fuenlabrada | 0.5 | 1–1 | 1.4 | CD Mirandés | 2,607 | Estadio Fernando Torres | Iosu Galech | Match Report | |
| Regular season | 17 | Sat | 2021-11-20 | 16:00 | Oviedo | 2.3 | 2–0 | 0.4 | Amorebieta | 8,473 | Estadio Carlos Tartiere | Víctor García Verdura | Match Report | |
| Regular season | 17 | Sat | 2021-11-20 | 18:15 | Málaga | 1.2 | 2–1 | 1.3 | Las Palmas | 22,128 | Estadio La Rosaleda | Eduardo Prieto | Match Report | |
| Regular season | 17 | Sat | 2021-11-20 | 20:30 | Almería | 1.8 | 3–1 | 0.5 | Valladolid | 9,208 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| Regular season | 17 | Sun | 2021-11-21 | 14:00 | Cartagena | 2.8 | 1–0 | 0.5 | Burgos | 5,476 | Estadio Municipal Cartagonova | Gorka Sagues | Match Report | |
| Regular season | 17 | Sun | 2021-11-21 | 16:00 | Lugo | 0.8 | 2–2 | 2.6 | Eibar | 2,709 | Estadio Anxo Carro | Saúl Ais | Match Report | |
| Regular season | 17 | Sun | 2021-11-21 | 17:15 | Tenerife | 0.6 | 1–0 | 0.5 | Alcorcón | 11,810 | Estadio Heliodoro Rodríguez Lopéz | Alejandro Quintero | Match Report | |
| Regular season | 17 | Sun | 2021-11-21 | 18:15 | Huesca | 1.8 | 0–0 | 1.2 | Ibiza | 6,164 | Estadio El Alcoraz | Aitor Gorostegui | Match Report | |
| Regular season | 17 | Sun | 2021-11-21 | 20:30 | Ponferradina | 2.1 | 4–1 | 0.8 | Sporting Gijón | 5,250 | Estadio El Toralín | José López | Match Report | |
| Regular season | 17 | Mon | 2021-11-22 | 19:00 | Real Sociedad B | 1.2 | 1–2 | 1.3 | Girona | 1,898 | Estadio Municipal de Anoeta | Francisco Hernández | Match Report | |
| Regular season | 17 | Mon | 2021-11-22 | 21:00 | Zaragoza | 0.5 | 0–2 | 0.9 | Leganés | 10,426 | Estadio de la Romareda | Dámaso Arcediano | Match Report | |
| Regular season | 18 | Fri | 2021-11-26 | 21:00 | CD Mirandés | 1.7 | 1–1 | 0.2 | Oviedo | 2,208 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| Regular season | 18 | Fri | 2021-11-26 | 21:00 | Alcorcón | 1.2 | 1–1 | 1.4 | Lugo | 1,042 | Estadio Santo Domingo | Raúl González | Match Report | |
| Regular season | 18 | Sat | 2021-11-27 | 16:00 | Burgos | 2.0 | 3–0 | 0.6 | Málaga | 7,246 | Estadio Municipal de El Plantío | Juan Pulido | Match Report | |
| Regular season | 18 | Sat | 2021-11-27 | 18:15 | Almería | 1.7 | 0–0 | 0.5 | Huesca | 9,486 | Estadio de los Juegos Mediterráneos | David Gálvez | Match Report | |
| Regular season | 18 | Sat | 2021-11-27 | 18:15 | Sporting Gijón | 1.1 | 1–1 | 0.4 | Fuenlabrada | 8,989 | Estadio Municipal El Molinón | Francisco Hernández | Match Report | |
| Regular season | 18 | Sat | 2021-11-27 | 20:30 | Valladolid | 2.5 | 2–0 | 0.7 | Cartagena | 11,314 | Estadio Municipal José Zorrilla | Álvaro Moreno | Match Report | |
| Regular season | 18 | Sun | 2021-11-28 | 14:00 | Leganés | 2.0 | 4–1 | 0.6 | Las Palmas | 7,008 | Estadio Municipal de Butarque | Rubén Ávalos | Match Report | |
| Regular season | 18 | Sun | 2021-11-28 | 16:00 | Amorebieta | 0.4 | 1–1 | 1.2 | Zaragoza | 1,250 | Instalaciones de Lezama Campo 2 | Oliver De La Fuente | Match Report | |
| Regular season | 18 | Sun | 2021-11-28 | 16:00 | Ibiza | 0.8 | 0–1 | 1.6 | Ponferradina | 3,971 | Estadio Municipal de Can Misses | Luis Milla | Match Report | |
| Regular season | 18 | Sun | 2021-11-28 | 17:15 | Tenerife | 1.5 | 2–0 | 1.3 | Real Sociedad B | 9,850 | Estadio Heliodoro Rodríguez Lopéz | José López | Match Report | |
| Regular season | 18 | Mon | 2021-11-29 | 21:00 | Eibar | 1.1 | 4–2 | 1.3 | Girona | 3,200 | Estadio Municipal de Ipurúa | Iván Caparrós | Match Report | |
| Regular season | 19 | Fri | 2021-12-03 | 21:00 | Huesca | 1.3 | 3–2 | 2.2 | Valladolid | 4,218 | Estadio El Alcoraz | Saúl Ais | Match Report | |
| Regular season | 19 | Sat | 2021-12-04 | 18:15 | Fuenlabrada | 0.6 | 1–1 | 0.9 | Almería | 2,052 | Estadio Fernando Torres | Juan Pulido | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 14:00 | Ponferradina | 1.0 | 2–1 | 1.8 | CD Mirandés | 4,098 | Estadio El Toralín | Aitor Gorostegui | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 16:00 | Málaga | 0.5 | 1–2 | 0.8 | Amorebieta | 18,980 | Estadio La Rosaleda | Daniel Trujillo | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 18:15 | Real Sociedad B | 0.7 | 0–1 | 0.9 | Burgos | 3,586 | Estadio Municipal de Anoeta | Alejandro Quintero | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 18:15 | Lugo | 0.9 | 0–0 | 0.3 | Ibiza | 2,360 | Estadio Anxo Carro | Víctor García Verdura | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 18:15 | Oviedo | 1.6 | 3–1 | 0.4 | Alcorcón | 7,102 | Estadio Carlos Tartiere | Gorka Sagues | Match Report | |
| Regular season | 19 | Sun | 2021-12-05 | 19:30 | Las Palmas | 1.7 | 1–0 | 0.6 | Sporting Gijón | 11,539 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| Regular season | 19 | Mon | 2021-12-06 | 16:00 | Zaragoza | 1.1 | 1–0 | 1.4 | Eibar | 16,109 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| Regular season | 19 | Mon | 2021-12-06 | 18:15 | Cartagena | 1.5 | 1–1 | 1.1 | Tenerife | 7,441 | Estadio Municipal Cartagonova | Iosu Galech | Match Report | |
| Regular season | 19 | Mon | 2021-12-06 | 21:00 | Girona | 1.4 | 3–0 | 0.7 | Leganés | 5,190 | Estadi Municipal de Montilivi | Eduardo Prieto | Match Report | |
| Regular season | 20 | Fri | 2021-12-10 | 21:00 | Sporting Gijón | 1.3 | 1–1 | 1.1 | Huesca | 9,680 | Estadio Municipal El Molinón | Daniel Trujillo | Match Report | |
| Regular season | 20 | Sat | 2021-12-11 | 16:00 | Burgos | 1.4 | 2–0 | 0.8 | Fuenlabrada | 8,107 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| Regular season | 20 | Sat | 2021-12-11 | 16:00 | Ibiza | 2.1 | 1–1 | 2.0 | Girona | 4,087 | Estadio Municipal de Can Misses | Oliver De La Fuente | Match Report | |
| Regular season | 20 | Sat | 2021-12-11 | 18:15 | Almería | 3.0 | 3–0 | 0.6 | Zaragoza | 9,258 | Estadio de los Juegos Mediterráneos | Francisco Hernández | Match Report | |
| Regular season | 20 | Sat | 2021-12-11 | 20:00 | Tenerife | 1.1 | 1–1 | 2.1 | Lugo | 9,617 | Estadio Heliodoro Rodríguez Lopéz | David Gálvez | Match Report | |
| Regular season | 20 | Sat | 2021-12-11 | 20:30 | Eibar | 2.1 | 2–2 | 1.4 | Málaga | 3,921 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| Regular season | 20 | Sun | 2021-12-12 | 14:00 | Leganés | 0.6 | 1–1 | 1.7 | Ponferradina | 7,117 | Estadio Municipal de Butarque | Raúl González | Match Report | |
| Regular season | 20 | Sun | 2021-12-12 | 16:00 | Valladolid | 0.9 | 2–1 | 1.7 | Oviedo | 15,309 | Estadio Municipal José Zorrilla | José López | Match Report | |
| Regular season | 20 | Sun | 2021-12-12 | 18:15 | Amorebieta | 1.6 | 1–1 | 1.0 | Las Palmas | 1,097 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| Regular season | 20 | Sun | 2021-12-12 | 18:15 | Alcorcón | 0.7 | 1–1 | 1.5 | Cartagena | 1,427 | Estadio Santo Domingo | Luis Milla | Match Report | |
| Regular season | 20 | Mon | 2021-12-13 | 21:00 | CD Mirandés | 1.8 | 2–0 | 0.4 | Real Sociedad B | 2,170 | Estadio Municipal de Anduva | Iván Caparrós | Match Report | |
| Regular season | 21 | Fri | 2021-12-17 | 21:00 | Girona | 2.4 | 3–1 | 1.3 | Burgos | 4,248 | Estadi Municipal de Montilivi | Saúl Ais | Match Report | |
| Regular season | 21 | Sat | 2021-12-18 | 16:00 | Ibiza | 2.6 | 0–2 | 1.5 | Sporting Gijón | 3,789 | Estadio Municipal de Can Misses | Iosu Galech | Match Report | |
| Regular season | 21 | Sat | 2021-12-18 | 16:00 | Málaga | 0.3 | 0–2 | 1.9 | Leganés | 14,571 | Estadio La Rosaleda | Javier Villanueva | Match Report | |
| Regular season | 21 | Sat | 2021-12-18 | 17:15 | Las Palmas | 1.2 | 0–1 | 0.8 | Eibar | 10,331 | Estadio de Gran Canaria | Eduardo Prieto | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 14:00 | Fuenlabrada | 0.9 | 0–0 | 1.3 | Oviedo | 2,127 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 16:00 | Ponferradina | 0.9 | 1–1 | 0.8 | Amorebieta | 5,432 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 16:00 | Zaragoza | 1.5 | 0–2 | 0.5 | Tenerife | 15,283 | Estadio de la Romareda | Alejandro Quintero | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 18:15 | Huesca | 0.6 | 0–0 | 0.5 | Alcorcón | 4,588 | Estadio El Alcoraz | Víctor García Verdura | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 18:15 | Real Sociedad B | 0.7 | 0–2 | 3.5 | Valladolid | 2,582 | Estadio Municipal de Anoeta | Alexis Carlos Pulido | Match Report | |
| Regular season | 21 | Sun | 2021-12-19 | 18:15 | Cartagena | 1.6 | 3–0 | 0.7 | CD Mirandés | 5,631 | Estadio Municipal Cartagonova | Jon González | Match Report | |
| Regular season | 22 | Fri | 2021-12-31 | 14:00 | Oviedo | 2.5 | 2–0 | 0.5 | Ponferradina | 7,125 | Estadio Carlos Tartiere | David Gálvez | Match Report | |
| Regular season | 22 | Fri | 2021-12-31 | 16:00 | Burgos | 1.3 | 2–2 | 1.5 | Amorebieta | 10,277 | Estadio Municipal de El Plantío | José López | Match Report | |
| Regular season | 22 | Fri | 2021-12-31 | 16:15 | Eibar | 1.2 | 3–2 | 2.0 | Real Sociedad B | 4,105 | Estadio Municipal de Ipurúa | Oliver De La Fuente | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 14:00 | Almería | 1.1 | 0–1 | 1.5 | Cartagena | 7,058 | Estadio de los Juegos Mediterráneos | Raúl González | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 14:00 | Valladolid | 2.0 | 1–0 | 0.8 | Leganés | 11,700 | Estadio Municipal José Zorrilla | Daniel Trujillo | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 16:00 | Sporting Gijón | 1.1 | 1–1 | 1.5 | Lugo | 12,462 | Estadio Municipal El Molinón | Rubén Ávalos | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 18:15 | CD Mirandés | 1.8 | 2–0 | 0.6 | Zaragoza | 3,076 | Estadio Municipal de Anduva | Luis Milla | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 18:15 | Huesca | 1.3 | 0–1 | 0.6 | Girona | 4,995 | Estadio El Alcoraz | Álvaro Moreno | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 20:30 | Tenerife | 1.1 | 0–1 | 0.7 | Las Palmas | 10,756 | Estadio Heliodoro Rodríguez Lopéz | Jon González | Match Report | |
| Regular season | 22 | Sun | 2022-01-02 | 21:00 | Fuenlabrada | 2.1 | 1–2 | 2.5 | Ibiza | 2,037 | Estadio Fernando Torres | Iván Caparrós | Match Report | |
| Regular season | 22 | Mon | 2022-01-03 | 21:00 | Alcorcón | 0.8 | 0–1 | 0.4 | Málaga | 1,111 | Estadio Santo Domingo | Rafael Sánchez | Match Report | |
| Regular season | 23 | Fri | 2022-01-07 | 21:00 | Amorebieta | 0.3 | 1–1 | 2.6 | Tenerife | 764 | Instalaciones de Lezama Campo 2 | Víctor García Verdura | Match Report | |
| Regular season | 23 | Sat | 2022-01-08 | 16:00 | Cartagena | 1.1 | 0–3 | 2.6 | Huesca | 6,596 | Estadio Municipal Cartagonova | Eduardo Prieto | Match Report | |
| Regular season | 23 | Sat | 2022-01-08 | 16:00 | Ibiza | 3.4 | 6–2 | 1.7 | Alcorcón | 3,337 | Estadio Municipal de Can Misses | Francisco Hernández | Match Report | |
| Regular season | 23 | Sat | 2022-01-08 | 18:15 | Valladolid | 1.7 | 1–0 | 0.3 | Burgos | 15,566 | Estadio Municipal José Zorrilla | Javier Villanueva | Match Report | |
| Regular season | 23 | Sat | 2022-01-08 | 21:00 | Leganés | 1.5 | 1–1 | 0.4 | Real Sociedad B | 4,828 | Estadio Municipal de Butarque | Saúl Ais | Match Report | |
| Regular season | 23 | Sun | 2022-01-09 | 14:00 | Girona | 1.3 | 2–1 | 0.4 | Fuenlabrada | 5,163 | Estadi Municipal de Montilivi | Alejandro Quintero | Match Report | |
| Regular season | 23 | Sun | 2022-01-09 | 16:00 | Lugo | 1.8 | 2–1 | 1.9 | CD Mirandés | 1,896 | Estadio Anxo Carro | Dámaso Arcediano | Match Report | |
| Regular season | 23 | Sun | 2022-01-09 | 18:15 | Málaga | 2.1 | 2–2 | 1.8 | Sporting Gijón | 14,470 | Estadio La Rosaleda | Gorka Sagues | Match Report | |
| Regular season | 23 | Sun | 2022-01-09 | 20:30 | Las Palmas | 1.6 | 1–1 | 0.4 | Almería | 9,827 | Estadio de Gran Canaria | David Gálvez | Match Report | |
| Regular season | 23 | Sun | 2022-01-09 | 20:30 | Ponferradina | 1.0 | 0–0 | 0.5 | Zaragoza | 3,282 | Estadio El Toralín | Iosu Galech | Match Report | |
| Regular season | 23 | Mon | 2022-01-10 | 21:00 | Oviedo | 1.1 | 1–1 | 0.9 | Eibar | 7,614 | Estadio Carlos Tartiere | Juan Pulido | Match Report | |
| Regular season | 21 | Wed | 2022-01-19 | 21:00 | Lugo | 1.4 | 2–1 | 1.5 | Almería | 1,445 | Estadio Anxo Carro | Gorka Sagues | Match Report | |
| Regular season | 24 | Fri | 2022-01-21 | 20:00 | Tenerife | 2.4 | 4–0 | 0.6 | Oviedo | 7,319 | Estadio Heliodoro Rodríguez Lopéz | Oliver De La Fuente | Match Report | |
| Regular season | 24 | Sat | 2022-01-22 | 16:00 | Zaragoza | 0.7 | 0–0 | 0.7 | Valladolid | 14,795 | Estadio de la Romareda | Jon González | Match Report | |
| Regular season | 24 | Sat | 2022-01-22 | 18:15 | Fuenlabrada | 2.1 | 3–2 | 2.1 | Las Palmas | 2,554 | Estadio Fernando Torres | Francisco Hernández | Match Report | |
| Regular season | 24 | Sat | 2022-01-22 | 21:00 | Málaga | 1.8 | 0–5 | 1.4 | Ibiza | 15,003 | Estadio La Rosaleda | Raúl González | Match Report | |
| Regular season | 24 | Sun | 2022-01-23 | 14:00 | Burgos | 1.9 | 4–0 | 0.4 | Leganés | 8,362 | Estadio Municipal de El Plantío | Rubén Ávalos | Match Report | |
| Regular season | 24 | Sun | 2022-01-23 | 16:00 | Sporting Gijón | 1.4 | 2–1 | 1.1 | Amorebieta | 12,970 | Estadio Municipal El Molinón | Rafael Sánchez | Match Report | |
| Regular season | 24 | Sun | 2022-01-23 | 18:15 | Huesca | 1.3 | 1–2 | 1.5 | Ponferradina | 5,109 | Estadio El Alcoraz | Iván Caparrós | Match Report | |
| Regular season | 24 | Sun | 2022-01-23 | 18:15 | Girona | 2.0 | 1–1 | 1.4 | Lugo | 5,580 | Estadi Municipal de Montilivi | Aitor Gorostegui | Match Report | |
| Regular season | 24 | Sun | 2022-01-23 | 21:00 | Alcorcón | 0.8 | 0–0 | 0.5 | CD Mirandés | 820 | Estadio Santo Domingo | José López | Match Report | |
| Regular season | 24 | Mon | 2022-01-24 | 21:00 | Almería | 1.2 | 0–2 | 0.7 | Eibar | 7,843 | Estadio de los Juegos Mediterráneos | Daniel Trujillo | Match Report | |
| Regular season | 24 | Mon | 2022-01-24 | 21:00 | Real Sociedad B | 1.7 | 1–2 | 2.0 | Cartagena | 985 | Estadio Municipal de Anoeta | Álvaro Moreno | Match Report | |
| Regular season | 25 | Fri | 2022-01-28 | 21:00 | Valladolid | 2.3 | 1–0 | 0.3 | Sporting Gijón | 13,221 | Estadio Municipal José Zorrilla | Luis Milla | Match Report | |
| Regular season | 25 | Sat | 2022-01-29 | 16:00 | Amorebieta | 0.8 | 1–0 | 0.4 | Girona | 954 | Instalaciones de Lezama Campo 2 | Eduardo Prieto | Match Report | |
| Regular season | 25 | Sat | 2022-01-29 | 18:15 | Lugo | 1.8 | 1–0 | 0.6 | Burgos | 2,836 | Estadio Anxo Carro | Jon González | Match Report | |
| Regular season | 25 | Sat | 2022-01-29 | 18:15 | Eibar | 1.8 | 2–1 | 1.9 | Huesca | 5,121 | Estadio Municipal de Ipurúa | Dámaso Arcediano | Match Report | |
| Regular season | 25 | Sat | 2022-01-29 | 21:00 | Oviedo | 0.4 | 2–0 | 0.8 | Almería | 10,543 | Estadio Carlos Tartiere | Javier Villanueva | Match Report | |
| Regular season | 25 | Sun | 2022-01-30 | 14:00 | Leganés | 1.2 | 1–0 | 1.2 | Alcorcón | 7,341 | Estadio Municipal de Butarque | Iosu Galech | Match Report | |
| Regular season | 25 | Sun | 2022-01-30 | 16:00 | Cartagena | 2.8 | 3–0 | 0.7 | Fuenlabrada | 7,514 | Estadio Municipal Cartagonova | Juan Pulido | Match Report | |
| Regular season | 25 | Sun | 2022-01-30 | 17:15 | Las Palmas | 1.1 | 0–0 | 1.5 | Real Sociedad B | 11,030 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| Regular season | 25 | Sun | 2022-01-30 | 18:15 | CD Mirandés | 2.0 | 3–0 | 0.6 | Málaga | 2,567 | Estadio Municipal de Anduva | Víctor García Verdura | Match Report | |
| Regular season | 25 | Sun | 2022-01-30 | 21:00 | Ponferradina | 0.9 | 1–2 | 2.1 | Tenerife | 3,963 | Estadio El Toralín | Gorka Sagues | Match Report | |
| Regular season | 25 | Mon | 2022-01-31 | 21:00 | Ibiza | 1.0 | 2–2 | 1.8 | Zaragoza | 4,678 | Estadio Municipal de Can Misses | Saúl Ais | Match Report | |
| Regular season | 26 | Fri | 2022-02-04 | 21:00 | Almería | 3.6 | 2–0 | 0.2 | Ibiza | 7,993 | Estadio de los Juegos Mediterráneos | Álvaro Moreno | Match Report | |
| Regular season | 26 | Fri | 2022-02-04 | 21:00 | Burgos | 1.4 | 3–1 | 0.9 | Alcorcón | 3,380 | Estadio Municipal de El Plantío | Raúl González | Match Report | |
| Regular season | 26 | Sat | 2022-02-05 | 16:00 | Real Sociedad B | 2.2 | 1–1 | 1.3 | Lugo | 5,356 | Estadio Municipal de Anoeta | Daniel Trujillo | Match Report | |
| Regular season | 26 | Sat | 2022-02-05 | 18:15 | Zaragoza | 2.1 | 1–1 | 0.5 | Málaga | 16,178 | Estadio de la Romareda | Francisco Hernández | Match Report | |
| Regular season | 26 | Sat | 2022-02-05 | 20:30 | Girona | 1.0 | 3–0 | 1.0 | Ponferradina | 5,675 | Estadi Municipal de Montilivi | Rafael Sánchez | Match Report | |
| Regular season | 26 | Sat | 2022-02-05 | 20:30 | Sporting Gijón | 0.7 | 0–1 | 1.1 | Eibar | 15,575 | Estadio Municipal El Molinón | José López | Match Report | |
| Regular season | 26 | Sun | 2022-02-06 | 14:00 | Amorebieta | 1.5 | 1–1 | 0.7 | Oviedo | 1,415 | Instalaciones de Lezama Campo 2 | Iván Caparrós | Match Report | |
| Regular season | 26 | Sun | 2022-02-06 | 14:00 | Fuenlabrada | 0.6 | 0–0 | 1.5 | Valladolid | 3,402 | Estadio Fernando Torres | Rubén Ávalos | Match Report | |
| Regular season | 26 | Sun | 2022-02-06 | 18:15 | Cartagena | 0.5 | 0–2 | 2.5 | Las Palmas | 9,382 | Estadio Municipal Cartagonova | Oliver De La Fuente | Match Report | |
| Regular season | 26 | Sun | 2022-02-06 | 18:15 | Huesca | 2.9 | 4–0 | 0.4 | CD Mirandés | 5,434 | Estadio El Alcoraz | David Gálvez | Match Report | |
| Regular season | 26 | Sun | 2022-02-06 | 20:00 | Tenerife | 1.6 | 0–0 | 0.3 | Leganés | 11,040 | Estadio Heliodoro Rodríguez Lopéz | Aitor Gorostegui | Match Report | |
| Regular season | 27 | Fri | 2022-02-11 | 21:00 | Leganés | 0.9 | 2–1 | 1.3 | Zaragoza | 8,244 | Estadio Municipal de Butarque | Dámaso Arcediano | Match Report | |
| Regular season | 27 | Sat | 2022-02-12 | 16:00 | CD Mirandés | 0.8 | 0–3 | 2.1 | Sporting Gijón | 2,795 | Estadio Municipal de Anduva | Eduardo Prieto | Match Report | |
| Regular season | 27 | Sat | 2022-02-12 | 18:15 | Valladolid | 2.6 | 2–2 | 2.1 | Girona | 14,570 | Estadio Municipal José Zorrilla | Juan Pulido | Match Report | |
| Regular season | 27 | Sat | 2022-02-12 | 18:15 | Ibiza | 2.4 | 2–1 | 0.9 | Cartagena | 4,408 | Estadio Municipal de Can Misses | Alejandro Quintero | Match Report | |
| Regular season | 27 | Sat | 2022-02-12 | 20:30 | Málaga | 0.4 | 0–1 | 1.2 | Almería | 17,267 | Estadio La Rosaleda | Jon González | Match Report | |
| Regular season | 27 | Sun | 2022-02-13 | 14:00 | Eibar | 0.9 | 0–0 | 1.0 | Fuenlabrada | 4,633 | Estadio Municipal de Ipurúa | Javier Villanueva | Match Report | |
| Regular season | 27 | Sun | 2022-02-13 | 16:00 | Oviedo | 1.8 | 3–3 | 3.7 | Huesca | 10,608 | Estadio Carlos Tartiere | Iosu Galech | Match Report | |
| Regular season | 27 | Sun | 2022-02-13 | 18:15 | Lugo | 0.6 | 1–1 | 1.1 | Amorebieta | 2,262 | Estadio Anxo Carro | Luis Milla | Match Report | |
| Regular season | 27 | Sun | 2022-02-13 | 18:15 | Alcorcón | 0.5 | 0–2 | 0.3 | Tenerife | 2,425 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| Regular season | 27 | Sun | 2022-02-13 | 20:00 | Las Palmas | 2.0 | 0–2 | 0.7 | Burgos | 9,803 | Estadio de Gran Canaria | Gorka Sagues | Match Report | |
| Regular season | 27 | Mon | 2022-02-14 | 21:00 | Ponferradina | 1.5 | 3–2 | 1.2 | Real Sociedad B | 3,300 | Estadio El Toralín | Víctor García Verdura | Match Report | |
| Regular season | 28 | Fri | 2022-02-18 | 21:00 | Cartagena | 1.3 | 2–3 | 2.2 | Valladolid | 6,963 | Estadio Municipal Cartagonova | Daniel Trujillo | Match Report | |
| Regular season | 28 | Sat | 2022-02-19 | 16:00 | Zaragoza | 0.8 | 2–1 | 2.1 | Las Palmas | 14,989 | Estadio de la Romareda | Iván Caparrós | Match Report | |
| Regular season | 28 | Sat | 2022-02-19 | 17:15 | Tenerife | 1.1 | 2–0 | 1.6 | Ibiza | 13,087 | Estadio Heliodoro Rodríguez Lopéz | Rubén Ávalos | Match Report | |
| Regular season | 28 | Sat | 2022-02-19 | 18:15 | Girona | 0.7 | 0–1 | 0.5 | Eibar | 6,551 | Estadi Municipal de Montilivi | Oliver De La Fuente | Match Report | |
| Regular season | 28 | Sat | 2022-02-19 | 21:00 | Real Sociedad B | 0.8 | 2–0 | 0.9 | Málaga | 4,661 | Estadio Municipal de Anoeta | José López | Match Report | |
| Regular season | 28 | Sun | 2022-02-20 | 14:00 | Fuenlabrada | 2.5 | 2–2 | 1.2 | Alcorcón | 3,328 | Estadio Fernando Torres | Rafael Sánchez | Match Report | |
| Regular season | 28 | Sun | 2022-02-20 | 16:00 | Burgos | 2.0 | 0–1 | 1.5 | Oviedo | 9,935 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| Regular season | 28 | Sun | 2022-02-20 | 18:15 | Huesca | 2.5 | 1–0 | 0.7 | Lugo | 6,097 | Estadio El Alcoraz | Álvaro Moreno | Match Report | |
| Regular season | 28 | Sun | 2022-02-20 | 18:15 | Sporting Gijón | 2.6 | 2–3 | 1.9 | Ponferradina | 16,480 | Estadio Municipal El Molinón | Francisco Hernández | Match Report | |
| Regular season | 28 | Sun | 2022-02-20 | 21:00 | Almería | 2.3 | 2–1 | 2.2 | CD Mirandés | 8,432 | Estadio de los Juegos Mediterráneos | Aitor Gorostegui | Match Report | |
| Regular season | 28 | Mon | 2022-02-21 | 21:00 | Amorebieta | 0.7 | 1–3 | 0.8 | Leganés | 860 | Instalaciones de Lezama Campo 2 | Raúl González | Match Report | |
| Regular season | 29 | Fri | 2022-02-25 | 21:00 | Almería | 3.1 | 3–1 | 0.9 | Fuenlabrada | 8,506 | Estadio de los Juegos Mediterráneos | Víctor García Verdura | Match Report | |
| Regular season | 29 | Sat | 2022-02-26 | 16:00 | Ibiza | 2.0 | 2–1 | 2.0 | Huesca | 4,263 | Estadio Municipal de Can Misses | Gorka Sagues | Match Report | |
| Regular season | 29 | Sat | 2022-02-26 | 16:00 | CD Mirandés | 1.6 | 2–1 | 1.4 | Tenerife | 2,652 | Estadio Municipal de Anduva | Dámaso Arcediano | Match Report | |
| Regular season | 29 | Sat | 2022-02-26 | 18:15 | Oviedo | 1.4 | 0–1 | 1.5 | Real Sociedad B | 10,486 | Estadio Carlos Tartiere | Luis Milla | Match Report | |
| Regular season | 29 | Sat | 2022-02-26 | 20:00 | Las Palmas | 2.0 | 2–2 | 0.9 | Lugo | 6,675 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| Regular season | 29 | Sun | 2022-02-27 | 14:00 | Eibar | 1.2 | 2–0 | 1.2 | Burgos | 5,135 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | |
| Regular season | 29 | Sun | 2022-02-27 | 16:00 | Sporting Gijón | 2.4 | 1–2 | 2.0 | Zaragoza | 15,470 | Estadio Municipal El Molinón | Jon González | Match Report | |
| Regular season | 29 | Sun | 2022-02-27 | 18:15 | Valladolid | 2.3 | 5–1 | 0.7 | Amorebieta | 14,108 | Estadio Municipal José Zorrilla | Iosu Galech | Match Report | |
| Regular season | 29 | Sun | 2022-02-27 | 18:15 | Leganés | 1.3 | 1–1 | 0.8 | Girona | 7,457 | Estadio Municipal de Butarque | Javier Villanueva | Match Report | |
| Regular season | 29 | Sun | 2022-02-27 | 21:00 | Alcorcón | 2.9 | 2–2 | 1.1 | Ponferradina | 1,237 | Estadio Santo Domingo | Eduardo Prieto | Match Report | |
| Regular season | 29 | Mon | 2022-02-28 | 21:00 | Málaga | 1.2 | 1–1 | 1.2 | Cartagena | 13,782 | Estadio La Rosaleda | Saúl Ais | Match Report | |
| Regular season | 30 | Fri | 2022-03-04 | 21:00 | Zaragoza | 0.9 | 2–0 | 1.9 | Almería | 14,000 | Estadio de la Romareda | Daniel Trujillo | Match Report | |
| Regular season | 30 | Sat | 2022-03-05 | 16:00 | Huesca | 1.5 | 0–0 | 1.3 | Las Palmas | 6,084 | Estadio El Alcoraz | Aitor Gorostegui | Match Report | |
| Regular season | 30 | Sat | 2022-03-05 | 16:00 | Fuenlabrada | 1.3 | 1–2 | 1.8 | Burgos | 3,188 | Estadio Fernando Torres | Iván Caparrós | Match Report | |
| Regular season | 30 | Sat | 2022-03-05 | 17:15 | Tenerife | 2.0 | 1–4 | 1.8 | Valladolid | 18,538 | Estadio Heliodoro Rodríguez Lopéz | Francisco Hernández | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 14:00 | Lugo | 1.1 | 1–0 | 1.4 | Alcorcón | 1,861 | Estadio Anxo Carro | José López | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 16:00 | Ponferradina | 0.9 | 1–1 | 2.0 | Ibiza | 4,797 | Estadio El Toralín | David Gálvez | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 18:15 | Leganés | 2.4 | 2–0 | 1.3 | CD Mirandés | 8,213 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 18:15 | Amorebieta | 1.0 | 1–2 | 1.1 | Málaga | 997 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 18:15 | Cartagena | 2.3 | 4–1 | 1.3 | Eibar | 5,097 | Estadio Municipal Cartagonova | Rubén Ávalos | Match Report | |
| Regular season | 30 | Sun | 2022-03-06 | 21:00 | Girona | 1.0 | 2–1 | 1.3 | Oviedo | 4,313 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| Regular season | 30 | Mon | 2022-03-07 | 21:00 | Real Sociedad B | 1.7 | 2–1 | 1.5 | Sporting Gijón | 3,032 | Estadio Municipal de Anoeta | Oliver De La Fuente | Match Report | |
| Regular season | 31 | Fri | 2022-03-11 | 21:00 | Zaragoza | 1.3 | 2–1 | 0.2 | Fuenlabrada | 16,317 | Estadio de la Romareda | Eduardo Prieto | Match Report | |
| Regular season | 31 | Sat | 2022-03-12 | 16:00 | CD Mirandés | 1.2 | 2–1 | 0.7 | Cartagena | 2,784 | Estadio Municipal de Anduva | Gorka Sagues | Match Report | |
| Regular season | 31 | Sat | 2022-03-12 | 16:00 | Ibiza | 1.3 | 1–1 | 0.7 | Leganés | 4,326 | Estadio Municipal de Can Misses | Daniel Trujillo | Match Report | |
| Regular season | 31 | Sat | 2022-03-12 | 17:15 | Las Palmas | 1.4 | 1–3 | 3.9 | Girona | 12,591 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| Regular season | 31 | Sat | 2022-03-12 | 18:15 | Almería | 1.9 | 3–3 | 0.6 | Lugo | 10,053 | Estadio de los Juegos Mediterráneos | Juan Pulido | Match Report | |
| Regular season | 31 | Sat | 2022-03-12 | 21:00 | Málaga | 1.0 | 0–0 | 0.6 | Ponferradina | 11,378 | Estadio La Rosaleda | Víctor García Verdura | Match Report | |
| Regular season | 31 | Sun | 2022-03-13 | 14:00 | Burgos | 0.6 | 0–0 | 0.7 | Real Sociedad B | 8,678 | Estadio Municipal de El Plantío | Alejandro Quintero | Match Report | |
| Regular season | 31 | Sun | 2022-03-13 | 16:00 | Sporting Gijón | 1.2 | 1–2 | 1.7 | Tenerife | 14,002 | Estadio Municipal El Molinón | Luis Milla | Match Report | |
| Regular season | 31 | Sun | 2022-03-13 | 16:00 | Eibar | 2.6 | 1–0 | 0.7 | Amorebieta | 5,741 | Estadio Municipal de Ipurúa | Saúl Ais | Match Report | |
| Regular season | 31 | Sun | 2022-03-13 | 18:15 | Oviedo | 1.7 | 3–0 | 0.6 | Valladolid | 12,224 | Estadio Carlos Tartiere | Javier Villanueva | Match Report | |
| Regular season | 31 | Sun | 2022-03-13 | 18:15 | Alcorcón | 1.3 | 1–0 | 0.5 | Huesca | 2,636 | Estadio Santo Domingo | Raúl González | Match Report | |
| Regular season | 32 | Fri | 2022-03-18 | 21:00 | Huesca | 1.3 | 1–0 | 0.3 | Burgos | 4,395 | Estadio El Alcoraz | Francisco Hernández | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 14:00 | Real Sociedad B | 2.1 | 1–3 | 1.4 | CD Mirandés | 8,531 | Estadio Municipal de Anoeta | David Gálvez | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 16:00 | Fuenlabrada | 0.7 | 1–0 | 0.7 | Málaga | 2,988 | Estadio Fernando Torres | Jon González | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 16:00 | Cartagena | 1.6 | 3–0 | 0.4 | Zaragoza | 7,056 | Estadio Municipal Cartagonova | José López | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 18:15 | Valladolid | 1.6 | 0–1 | 1.3 | Las Palmas | 15,252 | Estadio Municipal José Zorrilla | Luis Milla | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 18:15 | Lugo | 0.9 | 1–1 | 1.2 | Oviedo | 4,283 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| Regular season | 32 | Sat | 2022-03-19 | 21:00 | Girona | 1.9 | 5–1 | 1.3 | Ibiza | 4,827 | Estadi Municipal de Montilivi | Iosu Galech | Match Report | |
| Regular season | 32 | Sun | 2022-03-20 | 14:00 | Amorebieta | 1.0 | 0–0 | 0.6 | Alcorcón | 688 | Instalaciones de Lezama Campo 2 | Rafael Sánchez | Match Report | |
| Regular season | 32 | Sun | 2022-03-20 | 16:00 | Ponferradina | 1.3 | 2–2 | 1.2 | Eibar | 5,414 | Estadio El Toralín | Álvaro Moreno | Match Report | |
| Regular season | 32 | Sun | 2022-03-20 | 18:15 | Leganés | 0.7 | 1–1 | 0.6 | Sporting Gijón | 8,189 | Estadio Municipal de Butarque | Iván Caparrós | Match Report | |
| Regular season | 32 | Mon | 2022-03-21 | 20:00 | Tenerife | 0.9 | 0–1 | 1.0 | Almería | 15,007 | Estadio Heliodoro Rodríguez Lopéz | Oliver De La Fuente | Match Report | |
| Regular season | 33 | Fri | 2022-03-25 | 21:00 | Zaragoza | 1.2 | 1–1 | 0.8 | Amorebieta | 15,556 | Estadio de la Romareda | Rubén Ávalos | Match Report | |
| Regular season | 33 | Sat | 2022-03-26 | 14:00 | Ibiza | 1.4 | 2–2 | 1.9 | Real Sociedad B | 2,544 | Estadio Municipal de Can Misses | Dámaso Arcediano | Match Report | |
| Regular season | 33 | Sat | 2022-03-26 | 16:00 | Eibar | 1.9 | 1–0 | 0.3 | Lugo | 5,103 | Estadio Municipal de Ipurúa | Víctor García Verdura | Match Report | |
| Regular season | 33 | Sat | 2022-03-26 | 18:00 | Sporting Gijón | 2.0 | 4–1 | 0.9 | Cartagena | 14,182 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| Regular season | 33 | Sat | 2022-03-26 | 21:30 | Oviedo | 2.9 | 3–0 | 1.1 | Fuenlabrada | 11,134 | Estadio Carlos Tartiere | Raúl González | Match Report | |
| Regular season | 33 | Sun | 2022-03-27 | 14:00 | CD Mirandés | 3.5 | 3–1 | 0.7 | Ponferradina | 2,643 | Estadio Municipal de Anduva | Saúl Ais | Match Report | |
| Regular season | 33 | Sun | 2022-03-27 | 16:00 | Burgos | 1.5 | 1–0 | 0.3 | Tenerife | 8,898 | Estadio Municipal de El Plantío | Eduardo Prieto | Match Report | |
| Regular season | 33 | Sun | 2022-03-27 | 18:15 | Málaga | 0.9 | 0–2 | 1.7 | Huesca | 15,537 | Estadio La Rosaleda | Daniel Trujillo | Match Report | |
| Regular season | 33 | Sun | 2022-03-27 | 18:15 | Alcorcón | 1.2 | 1–2 | 0.8 | Valladolid | 2,497 | Estadio Santo Domingo | Alejandro Quintero | Match Report | |
| Regular season | 33 | Sun | 2022-03-27 | 21:00 | Almería | 2.3 | 0–1 | 1.6 | Girona | 9,260 | Estadio de los Juegos Mediterráneos | Gorka Sagues | Match Report | |
| Regular season | 33 | Mon | 2022-03-28 | 20:00 | Las Palmas | 2.2 | 4–2 | 0.9 | Leganés | 6,961 | Estadio de Gran Canaria | Javier Villanueva | Match Report | |
| Regular season | 34 | Fri | 2022-04-01 | 21:00 | Girona | 1.0 | 1–0 | 1.2 | Málaga | 5,863 | Estadi Municipal de Montilivi | Iván Caparrós | Match Report | |
| Regular season | 34 | Sat | 2022-04-02 | 16:00 | Valladolid | 2.0 | 4–1 | 1.0 | Lugo | 13,516 | Estadio Municipal José Zorrilla | Jon González | Match Report | |
| Regular season | 34 | Sat | 2022-04-02 | 16:00 | Real Sociedad B | 1.5 | 2–4 | 3.5 | Alcorcón | 6,866 | Estadio Municipal de Anoeta | Luis Milla | Match Report | |
| Regular season | 34 | Sat | 2022-04-02 | 18:15 | Amorebieta | 2.0 | 3–1 | 0.5 | Ibiza | 902 | Instalaciones de Lezama Campo 2 | Francisco Hernández | Match Report | |
| Regular season | 34 | Sat | 2022-04-02 | 19:30 | Tenerife | 0.5 | 1–1 | 2.3 | Zaragoza | 12,089 | Estadio Heliodoro Rodríguez Lopéz | David Gálvez | Match Report | |
| Regular season | 34 | Sun | 2022-04-03 | 14:00 | Cartagena | 1.4 | 1–2 | 0.9 | Oviedo | 7,181 | Estadio Municipal Cartagonova | Álvaro Moreno | Match Report | |
| Regular season | 34 | Sun | 2022-04-03 | 16:00 | Burgos | 0.7 | 0–0 | 0.6 | Sporting Gijón | 7,246 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| Regular season | 34 | Sun | 2022-04-03 | 16:00 | Ponferradina | 0.7 | 1–2 | 2.4 | Las Palmas | 5,745 | Estadio El Toralín | Aitor Gorostegui | Match Report | |
| Regular season | 34 | Sun | 2022-04-03 | 18:15 | Eibar | 1.3 | 1–1 | 1.0 | CD Mirandés | 5,480 | Estadio Municipal de Ipurúa | Iosu Galech | Match Report | |
| Regular season | 34 | Sun | 2022-04-03 | 18:15 | Huesca | 1.6 | 1–1 | 0.5 | Almería | 5,832 | Estadio El Alcoraz | José López | Match Report | |
| Regular season | 34 | Mon | 2022-04-04 | 21:00 | Leganés | 1.5 | 3–2 | 0.9 | Fuenlabrada | 6,898 | Estadio Municipal de Butarque | Oliver De La Fuente | Match Report | |
| Regular season | 35 | Fri | 2022-04-08 | 21:00 | Lugo | 2.2 | 1–0 | 1.1 | Cartagena | 2,197 | Estadio Anxo Carro | Eduardo Prieto | Match Report | |
| Regular season | 35 | Sat | 2022-04-09 | 16:00 | Real Sociedad B | 1.2 | 1–2 | 1.1 | Tenerife | 4,941 | Estadio Municipal de Anoeta | Rubén Ávalos | Match Report | |
| Regular season | 35 | Sat | 2022-04-09 | 18:15 | Alcorcón | 0.9 | 1–1 | 1.1 | Sporting Gijón | 2,075 | Estadio Santo Domingo | Gorka Sagues | Match Report | |
| Regular season | 35 | Sat | 2022-04-09 | 18:15 | Málaga | 2.1 | 2–2 | 2.5 | Valladolid | 18,004 | Estadio La Rosaleda | Juan Pulido | Match Report | |
| Regular season | 35 | Sat | 2022-04-09 | 20:00 | Las Palmas | 1.0 | 1–0 | 1.1 | Amorebieta | 12,825 | Estadio de Gran Canaria | Víctor García Verdura | Match Report | |
| Regular season | 35 | Sun | 2022-04-10 | 14:00 | Fuenlabrada | 0.9 | 2–3 | 0.9 | Huesca | 2,354 | Estadio Fernando Torres | Alejandro Quintero | Match Report | |
| Regular season | 35 | Sun | 2022-04-10 | 16:00 | Zaragoza | 1.3 | 1–0 | 0.7 | Girona | 17,957 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| Regular season | 35 | Sun | 2022-04-10 | 18:15 | CD Mirandés | 2.1 | 3–1 | 0.2 | Burgos | 4,924 | Estadio Municipal de Anduva | Raúl González | Match Report | |
| Regular season | 35 | Sun | 2022-04-10 | 18:15 | Oviedo | 0.4 | 1–0 | 0.5 | Leganés | 15,510 | Estadio Carlos Tartiere | Dámaso Arcediano | Match Report | |
| Regular season | 35 | Sun | 2022-04-10 | 18:15 | Ibiza | 1.4 | 2–0 | 1.3 | Eibar | 5,012 | Estadio Municipal de Can Misses | Saúl Ais | Match Report | |
| Regular season | 35 | Mon | 2022-04-11 | 21:00 | Almería | 1.4 | 3–0 | 0.3 | Ponferradina | 9,836 | Estadio de los Juegos Mediterráneos | Daniel Trujillo | Match Report | |
| Regular season | 36 | Fri | 2022-04-15 | 18:30 | Eibar | 2.1 | 2–2 | 1.4 | Las Palmas | 4,110 | Estadio Municipal de Ipurúa | José López | Match Report | |
| Regular season | 36 | Fri | 2022-04-15 | 21:00 | Amorebieta | 1.0 | 1–0 | 0.8 | CD Mirandés | 1,291 | Instalaciones de Lezama Campo 2 | David Gálvez | Match Report | |
| Regular season | 36 | Sat | 2022-04-16 | 16:00 | Leganés | 0.6 | 0–3 | 1.8 | Málaga | 5,169 | Estadio Municipal de Butarque | Aitor Gorostegui | Match Report | |
| Regular season | 36 | Sat | 2022-04-16 | 18:15 | Valladolid | 1.1 | 2–2 | 1.8 | Almería | 19,608 | Estadio Municipal José Zorrilla | Francisco Hernández | Match Report | |
| Regular season | 36 | Sat | 2022-04-16 | 20:30 | Sporting Gijón | 1.9 | 0–1 | 0.6 | Oviedo | 23,470 | Estadio Municipal El Molinón | Daniel Trujillo | Match Report | |
| Regular season | 36 | Sat | 2022-04-16 | 21:00 | Cartagena | 1.5 | 3–1 | 1.0 | Alcorcón | 6,801 | Estadio Municipal Cartagonova | Iosu Galech | Match Report | |
| Regular season | 36 | Sun | 2022-04-17 | 14:00 | Ponferradina | 0.5 | 3–1 | 1.5 | Lugo | 4,974 | Estadio El Toralín | Rafael Sánchez | Match Report | |
| Regular season | 36 | Sun | 2022-04-17 | 16:00 | Burgos | 1.5 | 2–1 | 1.5 | Ibiza | 8,624 | Estadio Municipal de El Plantío | Dámaso Arcediano | Match Report | |
| Regular season | 36 | Sun | 2022-04-17 | 17:15 | Tenerife | 1.8 | 3–1 | 0.4 | Fuenlabrada | 11,783 | Estadio Heliodoro Rodríguez Lopéz | Iván Caparrós | Match Report | |
| Regular season | 36 | Sun | 2022-04-17 | 18:15 | Huesca | 1.0 | 1–1 | 1.1 | Zaragoza | 8,143 | Estadio El Alcoraz | Jon González | Match Report | |
| Regular season | 36 | Mon | 2022-04-18 | 19:00 | Girona | 2.1 | 2–0 | 0.5 | Real Sociedad B | 7,432 | Estadi Municipal de Montilivi | Oliver De La Fuente | Match Report | |
| Regular season | 37 | Fri | 2022-04-22 | 20:00 | Tenerife | 1.1 | 0–0 | 0.4 | Huesca | 11,896 | Estadio Heliodoro Rodríguez Lopéz | Víctor García Verdura | Match Report | |
| Regular season | 37 | Sat | 2022-04-23 | 14:00 | Real Sociedad B | 1.5 | 2–1 | 2.2 | Amorebieta | 3,038 | Estadio Municipal de Anoeta | Raúl González | Match Report | |
| Regular season | 37 | Sat | 2022-04-23 | 16:15 | Fuenlabrada | 1.7 | 2–3 | 4.2 | Ponferradina | 2,119 | Estadio Fernando Torres | Rubén Ávalos | Match Report | |
| Regular season | 37 | Sat | 2022-04-23 | 16:15 | Cartagena | 2.2 | 3–0 | 2.0 | Girona | 3,306 | Estadio Municipal Cartagonova | Luis Milla | Match Report | |
| Regular season | 37 | Sat | 2022-04-23 | 18:30 | Málaga | 1.0 | 1–3 | 3.4 | Eibar | 17,667 | Estadio La Rosaleda | Javier Villanueva | Match Report | |
| Regular season | 37 | Sun | 2022-04-24 | 14:00 | Alcorcón | 1.0 | 1–2 | 0.9 | Oviedo | 2,543 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| Regular season | 37 | Sun | 2022-04-24 | 16:15 | Ibiza | 1.4 | 1–1 | 1.2 | Las Palmas | 4,328 | Estadio Municipal de Can Misses | Gorka Sagues | Match Report | |
| Regular season | 37 | Sun | 2022-04-24 | 16:15 | CD Mirandés | 1.5 | 0–1 | 0.7 | Valladolid | 41,040 | Estadio Municipal de Anduva | Álvaro Moreno | Match Report | |
| Regular season | 37 | Sun | 2022-04-24 | 18:30 | Zaragoza | 0.6 | 0–0 | 0.4 | Burgos | 17,987 | Estadio de la Romareda | José López | Match Report | |
| Regular season | 37 | Sun | 2022-04-24 | 18:30 | Lugo | 1.4 | 0–0 | 0.3 | Leganés | 2,261 | Estadio Anxo Carro | Alejandro Quintero | Match Report | |
| Regular season | 37 | Mon | 2022-04-25 | 21:00 | Almería | 2.5 | 1–0 | 0.5 | Sporting Gijón | 9,897 | Estadio de los Juegos Mediterráneos | Jon González | Match Report | |
| Regular season | 38 | Fri | 2022-04-29 | 21:00 | Las Palmas | 1.6 | 2–1 | 1.0 | Málaga | 10,644 | Estadio de Gran Canaria | Oliver De La Fuente | Match Report | |
| Regular season | 38 | Sat | 2022-04-30 | 16:00 | Oviedo | 1.7 | 3–0 | 0.8 | CD Mirandés | 15,108 | Estadio Carlos Tartiere | Iván Caparrós | Match Report | |
| Regular season | 38 | Sat | 2022-04-30 | 18:15 | Eibar | 1.8 | 2–0 | 0.2 | Zaragoza | 5,973 | Estadio Municipal de Ipurúa | Daniel Trujillo | Match Report | |
| Regular season | 38 | Sat | 2022-04-30 | 20:30 | Burgos | 2.0 | 0–2 | 1.2 | Almería | 8,479 | Estadio Municipal de El Plantío | Juan Pulido | Match Report | |
| Regular season | 38 | Sun | 2022-05-01 | 14:00 | Amorebieta | 2.1 | 2–1 | 1.2 | Fuenlabrada | 1,066 | Instalaciones de Lezama Campo 2 | Iosu Galech | Match Report | |
| Regular season | 38 | Sun | 2022-05-01 | 16:00 | Alcorcón | 0.2 | 0–1 | 2.1 | Girona | 951 | Estadio Santo Domingo | Aitor Gorostegui | Match Report | |
| Regular season | 38 | Sun | 2022-05-01 | 16:00 | Sporting Gijón | 1.2 | 0–1 | 0.6 | Ibiza | 11,740 | Estadio Municipal El Molinón | Eduardo Prieto | Match Report | |
| Regular season | 38 | Sun | 2022-05-01 | 18:15 | Ponferradina | 3.1 | 4–2 | 2.3 | Cartagena | 5,658 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| Regular season | 38 | Sun | 2022-05-01 | 18:15 | Lugo | 0.6 | 0–2 | 1.3 | Tenerife | 2,580 | Estadio Anxo Carro | Francisco Hernández | Match Report | |
| Regular season | 38 | Mon | 2022-05-02 | 18:30 | Leganés | 1.3 | 2–1 | 1.2 | Huesca | 4,416 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| Regular season | 38 | Mon | 2022-05-02 | 21:00 | Valladolid | 1.4 | 1–2 | 0.9 | Real Sociedad B | 14,326 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| Regular season | 39 | Fri | 2022-05-06 | 20:00 | Las Palmas | 1.4 | 1–0 | 1.1 | CD Mirandés | 11,299 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| Regular season | 39 | Sat | 2022-05-07 | 16:00 | Fuenlabrada | 1.4 | 1–2 | 2.5 | Real Sociedad B | 1,230 | Estadio Fernando Torres | José López | Match Report | |
| Regular season | 39 | Sat | 2022-05-07 | 16:00 | Huesca | 0.8 | 1–1 | 1.3 | Sporting Gijón | 4,740 | Estadio El Alcoraz | Raúl González | Match Report | |
| Regular season | 39 | Sat | 2022-05-07 | 18:15 | Almería | 3.0 | 3–0 | 0.5 | Amorebieta | 13,478 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| Regular season | 39 | Sat | 2022-05-07 | 18:15 | Málaga | 0.3 | 0–0 | 0.6 | Oviedo | 21,384 | Estadio La Rosaleda | Rubén Ávalos | Match Report | |
| Regular season | 39 | Sat | 2022-05-07 | 21:00 | Ponferradina | 2.0 | 3–1 | 1.8 | Burgos | 5,651 | Estadio El Toralín | Iosu Galech | Match Report | |
| Regular season | 39 | Sun | 2022-05-08 | 14:00 | Cartagena | 0.6 | 0–0 | 0.9 | Leganés | 4,560 | Estadio Municipal Cartagonova | Saúl Ais | Match Report | |
| Regular season | 39 | Sun | 2022-05-08 | 16:00 | Eibar | 0.5 | 0–2 | 1.6 | Valladolid | 7,237 | Estadio Municipal de Ipurúa | Luis Milla | Match Report | |
| Regular season | 39 | Sun | 2022-05-08 | 18:15 | Zaragoza | 1.9 | 0–3 | 1.3 | Alcorcón | 13,125 | Estadio de la Romareda | Gorka Sagues | Match Report | |
| Regular season | 39 | Sun | 2022-05-08 | 18:15 | Ibiza | 1.3 | 1–1 | 0.4 | Lugo | 3,262 | Estadio Municipal de Can Misses | Víctor García Verdura | Match Report | |
| Regular season | 39 | Mon | 2022-05-09 | 21:00 | Girona | 1.6 | 0–1 | 0.9 | Tenerife | 6,587 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| Regular season | 40 | Fri | 2022-05-13 | 21:00 | Real Sociedad B | 0.7 | 0–2 | 1.9 | Almería | 8,140 | Estadio Municipal de Anoeta | Iván Caparrós | Match Report | |
| Regular season | 40 | Sat | 2022-05-14 | 14:00 | Amorebieta | 1.2 | 1–0 | 0.5 | Huesca | 1,007 | Instalaciones de Lezama Campo 2 | Dámaso Arcediano | Match Report | |
| Regular season | 40 | Sat | 2022-05-14 | 16:00 | Lugo | 1.5 | 1–3 | 3.1 | Fuenlabrada | 1,639 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| Regular season | 40 | Sat | 2022-05-14 | 16:00 | Burgos | 1.3 | 1–1 | 1.0 | Cartagena | 7,296 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| Regular season | 40 | Sat | 2022-05-14 | 18:15 | Valladolid | 1.0 | 2–0 | 0.6 | Ponferradina | 20,213 | Estadio Municipal José Zorrilla | Daniel Trujillo | Match Report | |
| Regular season | 40 | Sat | 2022-05-14 | 21:00 | Leganés | 1.9 | 2–3 | 1.0 | Eibar | 5,752 | Estadio Municipal de Butarque | Francisco Hernández | Match Report | |
| Regular season | 40 | Sun | 2022-05-15 | 14:00 | Alcorcón | 1.1 | 0–2 | 1.0 | Las Palmas | 1,557 | Estadio Santo Domingo | Iosu Galech | Match Report | |
| Regular season | 40 | Sun | 2022-05-15 | 16:00 | Sporting Gijón | 1.1 | 2–1 | 0.6 | Girona | 20,140 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| Regular season | 40 | Sun | 2022-05-15 | 16:00 | CD Mirandés | 2.3 | 4–0 | 1.6 | Ibiza | 2,568 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| Regular season | 40 | Sun | 2022-05-15 | 20:00 | Tenerife | 1.4 | 0–2 | 0.8 | Málaga | 14,672 | Estadio Heliodoro Rodríguez Lopéz | Eduardo Prieto | Match Report | |
| Regular season | 40 | Mon | 2022-05-16 | 21:00 | Oviedo | 2.9 | 3–3 | 1.4 | Zaragoza | 13,529 | Estadio Carlos Tartiere | Oliver De La Fuente | Match Report | |
| Regular season | 41 | Fri | 2022-05-20 | 21:00 | Zaragoza | 1.2 | 1–0 | 1.7 | Lugo | 10,256 | Estadio de la Romareda | Álvaro Moreno | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 20:00 | Cartagena | 3.4 | 5–0 | 1.3 | Amorebieta | 4,244 | Estadio Municipal Cartagonova | Víctor García Verdura | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 20:00 | Málaga | 1.2 | 0–1 | 1.0 | Burgos | 25,389 | Estadio La Rosaleda | Jon González | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 20:00 | Huesca | 1.1 | 3–2 | 3.0 | Real Sociedad B | 3,811 | Estadio El Alcoraz | Alejandro Quintero | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 20:00 | Fuenlabrada | 1.1 | 0–0 | 0.6 | Sporting Gijón | 2,439 | Estadio Fernando Torres | Javier Villanueva | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 21:00 | Las Palmas | 0.6 | 2–1 | 0.7 | Oviedo | 30,063 | Estadio de Gran Canaria | Saúl Ais | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 22:00 | Ponferradina | 2.4 | 0–3 | 2.2 | Leganés | 7,361 | Estadio El Toralín | Luis Milla | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 22:00 | Girona | 2.4 | 2–0 | 0.3 | CD Mirandés | 6,925 | Estadi Municipal de Montilivi | Gorka Sagues | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 22:00 | Almería | 1.8 | 1–1 | 1.0 | Alcorcón | 14,759 | Estadio de los Juegos Mediterráneos | Raúl González | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 22:00 | Eibar | 3.2 | 2–0 | 0.3 | Tenerife | 7,135 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| Regular season | 41 | Sat | 2022-05-21 | 22:00 | Ibiza | 2.1 | 1–2 | 2.9 | Valladolid | 4,614 | Estadio Municipal de Can Misses | José López | Match Report | |
| Regular season | 42 | Fri | 2022-05-27 | 21:00 | Real Sociedad B | 0.6 | 1–2 | 2.5 | Zaragoza | 2,622 | Estadio Municipal de Anoeta | Rafael Sánchez | Match Report | |
| Regular season | 42 | Fri | 2022-05-27 | 21:00 | CD Mirandés | 2.6 | 5–1 | 1.6 | Fuenlabrada | 2,363 | Estadio Municipal de Anduva | Luis Milla | Match Report | |
| Regular season | 42 | Sat | 2022-05-28 | 18:15 | Amorebieta | 1.4 | 1–0 | 1.9 | Ponferradina | 1,218 | Instalaciones de Lezama Campo 2 | David Gálvez | Match Report | |
| Regular season | 42 | Sat | 2022-05-28 | 18:15 | Lugo | 1.5 | 1–0 | 0.5 | Málaga | 3,741 | Estadio Anxo Carro | Oliver De La Fuente | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 19:00 | Tenerife | 2.1 | 1–2 | 1.5 | Cartagena | 14,567 | Estadio Heliodoro Rodríguez Lopéz | Iosu Galech | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Sporting Gijón | 0.3 | 0–1 | 1.4 | Las Palmas | 12,346 | Estadio Municipal El Molinón | Eduardo Prieto | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Oviedo | 2.2 | 3–2 | 1.7 | Ibiza | 21,729 | Estadio Carlos Tartiere | Gorka Sagues | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Leganés | 1.8 | 2–2 | 1.5 | Almería | 8,654 | Estadio Municipal de Butarque | Dámaso Arcediano | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Valladolid | 2.2 | 3–0 | 0.4 | Huesca | 22,397 | Estadio Municipal José Zorrilla | Juan Pulido | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Alcorcón | 0.7 | 1–0 | 1.8 | Eibar | 2,319 | Estadio Santo Domingo | Iván Caparrós | Match Report | |
| Regular season | 42 | Sun | 2022-05-29 | 20:00 | Burgos | 1.0 | 0–0 | 0.3 | Girona | 11,152 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report | |
| Semi-finals | Wed | 2022-06-01 | 20:00 | Tenerife | 1.5 | 1–0 | 0.8 | Las Palmas | 19,732 | Estadio Heliodoro Rodríguez Lopéz | Javier Villanueva | Match Report | Leg 1 of 2 | |
| Semi-finals | Thu | 2022-06-02 | 19:00 | Girona | 0.8 | 0–1 | 0.5 | Eibar | 9,450 | Estadi Municipal de Montilivi | Luis Milla | Match Report | Leg 1 of 2 | |
| Semi-finals | Sat | 2022-06-04 | 20:00 | Las Palmas | 0.7 | 1–2 | 1.5 | Tenerife | 31,502 | Estadio de Gran Canaria | Jon González | Match Report | Leg 2 of 2; Tenerife won | |
| Semi-finals | Sun | 2022-06-05 | 18:30 | Eibar | 1.2 | 0–2 | 0.9 | Girona | 6,846 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | Leg 2 of 2; Girona won | |
| Final | Sat | 2022-06-11 | 21:00 | Girona | 0.9 | 0–0 | 0.2 | Tenerife | 11,303 | Estadi Municipal de Montilivi | Francisco Hernández | Match Report | Leg 1 of 2 | |
| Final | Sun | 2022-06-19 | 20:00 | Tenerife | 0.7 | 1–3 | 1.6 | Girona | 22,077 | Estadio Heliodoro Rodríguez Lopéz | Dámaso Arcediano | Match Report | Leg 2 of 2; Girona won |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-13 | 20:00 | Huesca | 0.5 | 2–0 | 0.8 | Eibar | 2,944 | Estadio El Alcoraz | José López | Match Report | |
| 1 | Fri | 2021-08-13 | 22:00 | Zaragoza | 0.5 | 0–0 | 0.6 | Ibiza | 6,745 | Estadio de la Romareda | Iosu Galech | Match Report | |
| 1 | Sat | 2021-08-14 | 17:00 | Real Sociedad B | 1.0 | 1–0 | 0.8 | Leganés | 2,597 | Estadio Municipal de Anoeta | Víctor García Verdura | Match Report | |
| 1 | Sat | 2021-08-14 | 19:30 | Girona | 1.5 | 2–0 | 0.5 | Amorebieta | 1,817 | Estadi Municipal de Montilivi | David Gálvez | Match Report | |
| 1 | Sat | 2021-08-14 | 22:00 | Ponferradina | 1.5 | 1–0 | 0.7 | Alcorcón | 2,743 | Estadio El Toralín | Javier Villanueva | Match Report | |
| 1 | Sun | 2021-08-15 | 17:00 | Sporting Gijón | 1.2 | 1–0 | 1.2 | Burgos | 10,170 | Estadio Municipal El Molinón | Gorka Sagues | Match Report | |
| 1 | Sun | 2021-08-15 | 19:30 | Oviedo | 1.0 | 2–2 | 1.7 | Lugo | 5,769 | Estadio Carlos Tartiere | Alejandro Quintero | Match Report | |
| 1 | Sun | 2021-08-15 | 21:00 | Las Palmas | 0.8 | 1–1 | 1.2 | Valladolid | 7,100 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| 1 | Sun | 2021-08-15 | 22:00 | Fuenlabrada | 0.6 | 1–2 | 1.1 | Tenerife | 1,184 | Estadio Fernando Torres | Saúl Ais | Match Report | |
| 1 | Mon | 2021-08-16 | 20:00 | Málaga | 1.5 | 0–0 | 0.4 | CD Mirandés | 6,519 | Estadio La Rosaleda | Juan Pulido | Match Report | |
| 1 | Mon | 2021-08-16 | 22:00 | Cartagena | 0.9 | 1–3 | 2.0 | Almería | 4,770 | Estadio Municipal Cartagonova | Aitor Gorostegui | Match Report | |
| 2 | Fri | 2021-08-20 | 20:00 | Valladolid | 0.9 | 2–0 | 1.8 | Zaragoza | 10,080 | Estadio Municipal José Zorrilla | Eduardo Prieto | Match Report | |
| 2 | Fri | 2021-08-20 | 22:00 | Almería | 1.6 | 2–1 | 0.4 | Oviedo | 4,100 | Estadio de los Juegos Mediterráneos | Francisco Hernández | Match Report | |
| 2 | Sat | 2021-08-21 | 17:00 | Lugo | 1.1 | 0–0 | 0.6 | Real Sociedad B | 1,657 | Estadio Anxo Carro | Raúl González | Match Report | |
| 2 | Sat | 2021-08-21 | 18:30 | Tenerife | 1.2 | 0–0 | 0.2 | Sporting Gijón | 4,999 | Estadio Heliodoro Rodríguez Lopéz | Rubén Ávalos | Match Report | |
| 2 | Sat | 2021-08-21 | 22:00 | Alcorcón | 1.4 | 0–2 | 1.4 | Fuenlabrada | 1,044 | Estadio Santo Domingo | Jon González | Match Report | |
| 2 | Sun | 2021-08-22 | 17:00 | Ibiza | 1.0 | 2–2 | 1.0 | Málaga | 2,487 | Estadio Municipal de Can Misses | Oliver De La Fuente | Match Report | |
| 2 | Sun | 2021-08-22 | 19:30 | Eibar | 1.7 | 0–1 | 0.5 | Ponferradina | 1,146 | Estadio Municipal de Ipurúa | Álvaro Moreno | Match Report | |
| 2 | Sun | 2021-08-22 | 19:30 | Girona | 1.0 | 0–0 | 0.2 | Las Palmas | 2,163 | Estadi Municipal de Montilivi | Luis Milla | Match Report | |
| 2 | Sun | 2021-08-22 | 22:00 | Huesca | 1.4 | 2–0 | 0.5 | Cartagena | 3,375 | Estadio El Alcoraz | Daniel Trujillo | Match Report | |
| 2 | Mon | 2021-08-23 | 20:00 | CD Mirandés | 2.1 | 2–0 | 1.4 | Amorebieta | 2,054 | Estadio Municipal de Anduva | Iván Caparrós | Match Report | |
| 2 | Mon | 2021-08-23 | 22:00 | Leganés | 1.8 | 0–0 | 0.3 | Burgos | 3,790 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| 3 | Fri | 2021-08-27 | 19:00 | Las Palmas | 1.3 | 2–1 | 0.8 | Huesca | 9,840 | Estadio de Gran Canaria | Javier Villanueva | Match Report | |
| 3 | Fri | 2021-08-27 | 22:00 | Málaga | 1.3 | 1–0 | 0.4 | Alcorcón | 6,884 | Estadio La Rosaleda | Aitor Gorostegui | Match Report | |
| 3 | Sat | 2021-08-28 | 17:00 | Sporting Gijón | 1.5 | 2–1 | 0.8 | CD Mirandés | 10,240 | Estadio Municipal El Molinón | Dámaso Arcediano | Match Report | |
| 3 | Sat | 2021-08-28 | 19:30 | Leganés | 1.4 | 1–2 | 0.9 | Ibiza | 4,454 | Estadio Municipal de Butarque | Alejandro Quintero | Match Report | |
| 3 | Sat | 2021-08-28 | 19:30 | Oviedo | 0.8 | 0–0 | 0.4 | Tenerife | 6,381 | Estadio Carlos Tartiere | José López | Match Report | |
| 3 | Sat | 2021-08-28 | 22:00 | Ponferradina | 0.7 | 2–1 | 1.3 | Girona | 3,397 | Estadio El Toralín | Juan Pulido | Match Report | |
| 3 | Sun | 2021-08-29 | 17:00 | Amorebieta | 1.3 | 2–1 | 1.1 | Almería | 592 | Instalaciones de Lezama Campo 2 | Víctor García Verdura | Match Report | |
| 3 | Sun | 2021-08-29 | 19:30 | Lugo | 1.2 | 0–2 | 0.4 | Valladolid | 1,856 | Estadio Anxo Carro | Gorka Sagues | Match Report | |
| 3 | Sun | 2021-08-29 | 19:30 | Real Sociedad B | 1.7 | 0–0 | 0.1 | Fuenlabrada | 4,450 | Estadio Municipal de Anoeta | Iosu Galech | Match Report | |
| 3 | Sun | 2021-08-29 | 22:00 | Burgos | 1.0 | 0–1 | 0.6 | Eibar | 4,373 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| 3 | Mon | 2021-08-30 | 22:00 | Zaragoza | 0.5 | 0–1 | 0.6 | Cartagena | 10,704 | Estadio de la Romareda | Saúl Ais | Match Report | |
| 4 | Fri | 2021-09-03 | 21:00 | Girona | 1.6 | 1–2 | 1.8 | Sporting Gijón | 2,141 | Estadi Municipal de Montilivi | Daniel Trujillo | Match Report | |
| 4 | Sat | 2021-09-04 | 16:00 | Eibar | 1.6 | 1–1 | 0.6 | Leganés | 1,685 | Estadio Municipal de Ipurúa | Luis Milla | Match Report | |
| 4 | Sat | 2021-09-04 | 17:15 | Tenerife | 1.1 | 2–0 | 0.8 | Ponferradina | 6,940 | Estadio Heliodoro Rodríguez Lopéz | Francisco Hernández | Match Report | |
| 4 | Sat | 2021-09-04 | 18:15 | Cartagena | 1.2 | 1–0 | 1.1 | Real Sociedad B | 5,108 | Estadio Municipal Cartagonova | Iván Caparrós | Match Report | |
| 4 | Sat | 2021-09-04 | 21:00 | Almería | 1.7 | 2–0 | 1.6 | Málaga | 6,353 | Estadio de los Juegos Mediterráneos | Jon González | Match Report | |
| 4 | Sat | 2021-09-04 | 21:00 | Fuenlabrada | 1.5 | 1–1 | 0.4 | Lugo | 1,701 | Estadio Fernando Torres | Oliver De La Fuente | Match Report | |
| 4 | Sun | 2021-09-05 | 16:00 | Burgos | 1.8 | 3–0 | 0.6 | Valladolid | 5,567 | Estadio Municipal de El Plantío | Álvaro Moreno | Match Report | |
| 4 | Sun | 2021-09-05 | 16:00 | Ibiza | 2.6 | 1–1 | 0.7 | Amorebieta | 3,119 | Estadio Municipal de Can Misses | Raúl González | Match Report | |
| 4 | Sun | 2021-09-05 | 18:15 | Alcorcón | 1.2 | 1–2 | 1.7 | Zaragoza | 1,744 | Estadio Santo Domingo | Rubén Ávalos | Match Report | |
| 4 | Sun | 2021-09-05 | 18:15 | CD Mirandés | 2.1 | 4–2 | 1.3 | Las Palmas | 2,513 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| 4 | Mon | 2021-09-06 | 21:00 | Huesca | 2.1 | 1–2 | 0.9 | Oviedo | 5,219 | Estadio El Alcoraz | Eduardo Prieto | Match Report | |
| 5 | Fri | 2021-09-10 | 21:00 | Sporting Gijón | 2.2 | 2–1 | 0.8 | Leganés | 11,212 | Estadio Municipal El Molinón | Javier Villanueva | Match Report | |
| 5 | Sat | 2021-09-11 | 16:00 | Amorebieta | 1.7 | 2–2 | 1.7 | Burgos | 832 | Instalaciones de Lezama Campo 2 | Alejandro Quintero | Match Report | |
| 5 | Sat | 2021-09-11 | 16:00 | Real Sociedad B | 0.7 | 2–3 | 1.6 | Eibar | 6,266 | Estadio Municipal de Anoeta | Juan Pulido | Match Report | |
| 5 | Sat | 2021-09-11 | 17:15 | Las Palmas | 0.9 | 1–1 | 0.7 | Ibiza | 11,726 | Estadio de Gran Canaria | Víctor García Verdura | Match Report | |
| 5 | Sat | 2021-09-11 | 21:00 | CD Mirandés | 0.9 | 1–3 | 1.8 | Alcorcón | 2,356 | Estadio Municipal de Anduva | Gorka Sagues | Match Report | |
| 5 | Sun | 2021-09-12 | 14:00 | Oviedo | 2.5 | 2–0 | 0.9 | Cartagena | 6,823 | Estadio Carlos Tartiere | Iosu Galech | Match Report | |
| 5 | Sun | 2021-09-12 | 16:00 | Valladolid | 0.7 | 0–2 | 1.4 | Tenerife | 13,699 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| 5 | Sun | 2021-09-12 | 18:15 | Ponferradina | 1.1 | 1–0 | 0.4 | Almería | 3,935 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| 5 | Sun | 2021-09-12 | 20:30 | Fuenlabrada | 1.5 | 1–1 | 3.0 | Zaragoza | 2,240 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| 5 | Sun | 2021-09-12 | 21:30 | Málaga | 2.0 | 2–0 | 0.7 | Girona | 11,108 | Estadio La Rosaleda | José López | Match Report | |
| 5 | Mon | 2021-09-13 | 21:00 | Lugo | 2.8 | 3–2 | 0.5 | Huesca | 1,909 | Estadio Anxo Carro | Saúl Ais | Match Report | |
| 6 | Fri | 2021-09-17 | 21:00 | Alcorcón | 1.1 | 0–4 | 3.1 | Almería | 1,559 | Estadio Santo Domingo | Raúl González | Match Report | |
| 6 | Sat | 2021-09-18 | 16:00 | Ibiza | 0.8 | 1–1 | 1.8 | Oviedo | 3,119 | Estadio Municipal de Can Misses | Álvaro Moreno | Match Report | |
| 6 | Sat | 2021-09-18 | 18:15 | Zaragoza | 2.1 | 1–1 | 0.5 | Real Sociedad B | 14,726 | Estadio de la Romareda | Oliver De La Fuente | Match Report | |
| 6 | Sat | 2021-09-18 | 18:15 | Leganés | 1.2 | 1–0 | 0.9 | Amorebieta | 6,342 | Estadio Municipal de Butarque | Daniel Trujillo | Match Report | |
| 6 | Sat | 2021-09-18 | 20:30 | Girona | 1.7 | 1–0 | 0.6 | Valladolid | 3,534 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| 6 | Sat | 2021-09-18 | 21:00 | Cartagena | 1.8 | 2–1 | 0.7 | Lugo | 5,536 | Estadio Municipal Cartagonova | Eduardo Prieto | Match Report | |
| 6 | Sun | 2021-09-19 | 14:00 | Huesca | 0.4 | 0–0 | 1.2 | Fuenlabrada | 5,183 | Estadio El Alcoraz | Dámaso Arcediano | Match Report | |
| 6 | Sun | 2021-09-19 | 16:00 | Ponferradina | 2.4 | 4–0 | 0.9 | Málaga | 3,993 | Estadio El Toralín | Rafael Sánchez | Match Report | |
| 6 | Sun | 2021-09-19 | 17:15 | Tenerife | 2.1 | 1–2 | 1.4 | CD Mirandés | 9,957 | Estadio Heliodoro Rodríguez Lopéz | Luis Milla | Match Report | |
| 6 | Sun | 2021-09-19 | 18:15 | Eibar | 1.3 | 3–2 | 0.9 | Sporting Gijón | 2,462 | Estadio Municipal de Ipurúa | Francisco Hernández | Match Report | |
| 6 | Mon | 2021-09-20 | 21:00 | Burgos | 0.5 | 0–0 | 1.2 | Las Palmas | 5,437 | Estadio Municipal de El Plantío | Iván Caparrós | Match Report | |
| 7 | Fri | 2021-09-24 | 20:00 | Real Sociedad B | 1.4 | 0–2 | 2.2 | Huesca | 3,171 | Estadio Municipal de Anoeta | José López | Match Report | |
| 7 | Fri | 2021-09-24 | 21:00 | Almería | 2.2 | 3–1 | 1.6 | Tenerife | 7,074 | Estadio de los Juegos Mediterráneos | Rubén Ávalos | Match Report | |
| 7 | Sat | 2021-09-25 | 16:00 | Ibiza | 1.6 | 2–0 | 1.1 | Burgos | 3,742 | Estadio Municipal de Can Misses | Aitor Gorostegui | Match Report | |
| 7 | Sat | 2021-09-25 | 17:15 | Las Palmas | 2.1 | 2–1 | 1.4 | Ponferradina | 10,210 | Estadio de Gran Canaria | Gorka Sagues | Match Report | |
| 7 | Sat | 2021-09-25 | 18:15 | Amorebieta | 1.0 | 1–1 | 2.4 | Eibar | 1,236 | Instalaciones de Lezama Campo 2 | Javier Villanueva | Match Report | |
| 7 | Sun | 2021-09-26 | 14:00 | CD Mirandés | 1.0 | 1–2 | 2.0 | Leganés | 2,399 | Estadio Municipal de Anduva | Francisco Hernández | Match Report | |
| 7 | Sun | 2021-09-26 | 16:00 | Sporting Gijón | 2.3 | 2–1 | 0.2 | Málaga | 13,482 | Estadio Municipal El Molinón | Iosu Galech | Match Report | |
| 7 | Sun | 2021-09-26 | 18:15 | Oviedo | 0.7 | 0–0 | 0.6 | Girona | 9,163 | Estadio Carlos Tartiere | David Gálvez | Match Report | |
| 7 | Sun | 2021-09-26 | 20:30 | Lugo | 2.0 | 1–1 | 1.9 | Zaragoza | 2,135 | Estadio Anxo Carro | Víctor García Verdura | Match Report | |
| 7 | Sun | 2021-09-26 | 21:00 | Valladolid | 1.8 | 2–0 | 0.6 | Alcorcón | 12,395 | Estadio Municipal José Zorrilla | Saúl Ais | Match Report | |
| 7 | Mon | 2021-09-27 | 21:00 | Fuenlabrada | 1.5 | 2–1 | 1.5 | Cartagena | 2,109 | Estadio Fernando Torres | Alejandro Quintero | Match Report | |
| 8 | Fri | 2021-10-01 | 21:00 | Ponferradina | 1.5 | 2–2 | 1.3 | Valladolid | 4,979 | Estadio El Toralín | José López | Match Report | |
| 8 | Sat | 2021-10-02 | 16:00 | Amorebieta | 0.9 | 1–1 | 0.8 | Sporting Gijón | 1,178 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| 8 | Sat | 2021-10-02 | 16:00 | Huesca | 1.0 | 1–2 | 1.0 | Tenerife | 6,826 | Estadio El Alcoraz | Jon González | Match Report | |
| 8 | Sat | 2021-10-02 | 18:15 | Zaragoza | 1.4 | 0–0 | 0.4 | Oviedo | 16,889 | Estadio de la Romareda | Luis Milla | Match Report | |
| 8 | Sat | 2021-10-02 | 21:00 | Alcorcón | 1.3 | 1–4 | 1.8 | Real Sociedad B | 1,357 | Estadio Santo Domingo | Rafael Sánchez | Match Report | |
| 8 | Sun | 2021-10-03 | 14:00 | Eibar | 1.5 | 3–1 | 1.7 | Ibiza | 2,719 | Estadio Municipal de Ipurúa | Eduardo Prieto | Match Report | |
| 8 | Sun | 2021-10-03 | 16:00 | Málaga | 0.8 | 1–0 | 0.9 | Fuenlabrada | 12,831 | Estadio La Rosaleda | Raúl González | Match Report | |
| 8 | Sun | 2021-10-03 | 17:15 | Las Palmas | 3.8 | 4–1 | 0.9 | Cartagena | 11,873 | Estadio de Gran Canaria | Oliver De La Fuente | Match Report | |
| 8 | Sun | 2021-10-03 | 18:15 | Burgos | 0.6 | 1–0 | 0.7 | CD Mirandés | 8,600 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report | |
| 8 | Sun | 2021-10-03 | 21:00 | Leganés | 0.5 | 1–1 | 0.9 | Lugo | 6,131 | Estadio Municipal de Butarque | Iván Caparrós | Match Report | |
| 8 | Mon | 2021-10-04 | 21:00 | Girona | 1.5 | 1–2 | 2.5 | Almería | 4,904 | Estadi Municipal de Montilivi | Juan Pulido | Match Report | |
| 9 | Fri | 2021-10-08 | 21:00 | Valladolid | 2.0 | 1–1 | 1.1 | Málaga | 14,408 | Estadio Municipal José Zorrilla | Javier Villanueva | Match Report | |
| 9 | Sat | 2021-10-09 | 16:00 | Lugo | 1.2 | 1–0 | 0.7 | Girona | 2,685 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| 9 | Sat | 2021-10-09 | 16:00 | CD Mirandés | 1.7 | 3–3 | 3.5 | Eibar | 2,953 | Estadio Municipal de Anduva | Dámaso Arcediano | Match Report | |
| 9 | Sat | 2021-10-09 | 18:15 | Almería | 1.7 | 1–1 | 0.7 | Las Palmas | 8,734 | Estadio de los Juegos Mediterráneos | Saúl Ais | Match Report | |
| 9 | Sat | 2021-10-09 | 21:00 | Oviedo | 0.6 | 1–1 | 0.9 | Sporting Gijón | 21,053 | Estadio Carlos Tartiere | Rubén Ávalos | Match Report | |
| 9 | Sun | 2021-10-10 | 14:00 | Real Sociedad B | 1.0 | 1–1 | 0.5 | Ponferradina | 972 | Estadio Municipal de Anoeta | Alejandro Quintero | Match Report | |
| 9 | Sun | 2021-10-10 | 16:00 | Cartagena | 3.0 | 5–1 | 0.8 | Ibiza | 6,000 | Estadio Municipal Cartagonova | David Gálvez | Match Report | |
| 9 | Sun | 2021-10-10 | 17:15 | Tenerife | 1.3 | 2–1 | 0.8 | Amorebieta | 12,572 | Estadio Heliodoro Rodríguez Lopéz | Víctor García Verdura | Match Report | |
| 9 | Sun | 2021-10-10 | 18:15 | Alcorcón | 1.2 | 1–0 | 0.5 | Burgos | 1,953 | Estadio Santo Domingo | Iosu Galech | Match Report | |
| 9 | Sun | 2021-10-10 | 18:15 | Fuenlabrada | 0.9 | 2–1 | 0.9 | Leganés | 3,244 | Estadio Fernando Torres | Gorka Sagues | Match Report | |
| 9 | Mon | 2021-10-11 | 21:00 | Zaragoza | 1.3 | 0–0 | 0.8 | Huesca | 25,307 | Estadio de la Romareda | Francisco Hernández | Match Report | |
| 10 | Fri | 2021-10-15 | 21:00 | Eibar | 1.0 | 1–0 | 1.4 | Almería | 3,630 | Estadio Municipal de Ipurúa | José López | Match Report | |
| 10 | Sat | 2021-10-16 | 16:00 | Girona | 2.6 | 1–3 | 1.7 | Huesca | 6,101 | Estadi Municipal de Montilivi | Álvaro Moreno | Match Report | |
| 10 | Sat | 2021-10-16 | 16:00 | Amorebieta | 1.7 | 2–3 | 1.1 | Cartagena | 878 | Instalaciones de Lezama Campo 2 | Juan Pulido | Match Report | |
| 10 | Sat | 2021-10-16 | 17:15 | Las Palmas | 1.0 | 2–1 | 0.5 | Tenerife | 25,887 | Estadio de Gran Canaria | Eduardo Prieto | Match Report | |
| 10 | Sat | 2021-10-16 | 20:30 | Málaga | 1.7 | 1–1 | 0.4 | Zaragoza | 15,901 | Estadio La Rosaleda | Jon González | Match Report | |
| 10 | Sat | 2021-10-16 | 21:00 | Sporting Gijón | 3.2 | 1–0 | 0.4 | Alcorcón | 14,146 | Estadio Municipal El Molinón | Oliver De La Fuente | Match Report | |
| 10 | Sun | 2021-10-17 | 14:00 | Ibiza | 1.6 | 0–2 | 0.8 | CD Mirandés | 3,217 | Estadio Municipal de Can Misses | Iván Caparrós | Match Report | |
| 10 | Sun | 2021-10-17 | 16:00 | Leganés | 1.0 | 0–2 | 1.0 | Valladolid | 7,436 | Estadio Municipal de Butarque | Luis Milla | Match Report | |
| 10 | Sun | 2021-10-17 | 18:15 | Burgos | 2.0 | 1–1 | 1.4 | Lugo | 6,352 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| 10 | Sun | 2021-10-17 | 18:15 | Real Sociedad B | 0.8 | 1–1 | 1.9 | Oviedo | 3,028 | Estadio Municipal de Anoeta | Raúl González | Match Report | |
| 10 | Sun | 2021-10-17 | 21:00 | Ponferradina | 1.4 | 0–0 | 0.4 | Fuenlabrada | 4,219 | Estadio El Toralín | Daniel Trujillo | Match Report | |
| 11 | Tue | 2021-10-19 | 19:00 | Huesca | 0.8 | 0–0 | 0.7 | Málaga | 6,333 | Estadio El Alcoraz | David Gálvez | Match Report | |
| 11 | Tue | 2021-10-19 | 19:00 | Cartagena | 2.2 | 1–0 | 0.6 | Sporting Gijón | 6,719 | Estadio Municipal Cartagonova | Saúl Ais | Match Report | |
| 11 | Tue | 2021-10-19 | 20:00 | Tenerife | 0.6 | 0–1 | 0.5 | Eibar | 9,283 | Estadio Heliodoro Rodríguez Lopéz | Iosu Galech | Match Report | |
| 11 | Wed | 2021-10-20 | 19:00 | Fuenlabrada | 0.5 | 0–0 | 0.8 | Amorebieta | 2,087 | Estadio Fernando Torres | Francisco Hernández | Match Report | |
| 11 | Wed | 2021-10-20 | 19:00 | Valladolid | 2.4 | 1–1 | 0.9 | Ibiza | 12,991 | Estadio Municipal José Zorrilla | Gorka Sagues | Match Report | |
| 11 | Wed | 2021-10-20 | 21:00 | Lugo | 0.3 | 2–0 | 0.6 | Las Palmas | 2,110 | Estadio Anxo Carro | Rubén Ávalos | Match Report | |
| 11 | Wed | 2021-10-20 | 21:00 | Alcorcón | 1.1 | 3–3 | 3.1 | Leganés | 1,700 | Estadio Santo Domingo | Dámaso Arcediano | Match Report | |
| 11 | Thu | 2021-10-21 | 18:45 | Almería | 3.2 | 3–1 | 0.6 | Real Sociedad B | 7,697 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| 11 | Thu | 2021-10-21 | 19:00 | Zaragoza | 2.0 | 1–1 | 1.1 | Ponferradina | 15,676 | Estadio de la Romareda | Aitor Gorostegui | Match Report | |
| 11 | Thu | 2021-10-21 | 21:00 | Oviedo | 2.0 | 1–3 | 0.9 | Burgos | 7,411 | Estadio Carlos Tartiere | Víctor García Verdura | Match Report | |
| 11 | Thu | 2021-10-21 | 21:00 | CD Mirandés | 0.8 | 1–2 | 1.5 | Girona | 2,307 | Estadio Municipal de Anduva | Alejandro Quintero | Match Report | |
| 12 | Fri | 2021-10-22 | 21:00 | Eibar | 1.9 | 2–1 | 0.7 | Cartagena | 21,128 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| 12 | Sat | 2021-10-23 | 16:00 | Ibiza | 1.4 | 3–1 | 1.8 | Fuenlabrada | 3,419 | Estadio Municipal de Can Misses | Rafael Sánchez | Match Report | |
| 12 | Sat | 2021-10-23 | 18:15 | Sporting Gijón | 1.9 | 1–2 | 0.8 | Valladolid | 16,541 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| 12 | Sat | 2021-10-23 | 20:30 | Málaga | 1.7 | 1–0 | 0.5 | Lugo | 14,980 | Estadio La Rosaleda | Álvaro Moreno | Match Report | |
| 12 | Sat | 2021-10-23 | 21:00 | Leganés | 0.8 | 1–2 | 1.0 | Tenerife | 6,454 | Estadio Municipal de Butarque | Oliver De La Fuente | Match Report | |
| 12 | Sun | 2021-10-24 | 14:00 | CD Mirandés | 1.2 | 1–4 | 2.1 | Almería | 2,365 | Estadio Municipal de Anduva | Jon González | Match Report | |
| 12 | Sun | 2021-10-24 | 14:00 | Amorebieta | 0.9 | 1–2 | 1.5 | Real Sociedad B | 996 | Instalaciones de Lezama Campo 2 | Daniel Trujillo | Match Report | |
| 12 | Sun | 2021-10-24 | 18:15 | Burgos | 0.8 | 3–1 | 0.9 | Huesca | 6,145 | Estadio Municipal de El Plantío | Luis Milla | Match Report | |
| 12 | Sun | 2021-10-24 | 18:15 | Ponferradina | 1.1 | 1–2 | 1.7 | Oviedo | 5,600 | Estadio El Toralín | Eduardo Prieto | Match Report | |
| 12 | Sun | 2021-10-24 | 20:00 | Las Palmas | 2.2 | 3–0 | 0.2 | Alcorcón | 8,936 | Estadio de Gran Canaria | Iván Caparrós | Match Report | |
| 12 | Mon | 2021-10-25 | 21:00 | Girona | 1.5 | 1–1 | 0.9 | Zaragoza | 5,162 | Estadi Municipal de Montilivi | Raúl González | Match Report | |
| 13 | Fri | 2021-10-29 | 21:00 | Real Sociedad B | 1.2 | 0–1 | 1.1 | Las Palmas | 2,320 | Estadio Municipal de Anoeta | Dámaso Arcediano | Match Report | |
| 13 | Fri | 2021-10-29 | 21:00 | Almería | 0.8 | 1–0 | 1.4 | Leganés | 8,867 | Estadio de los Juegos Mediterráneos | Iosu Galech | Match Report | |
| 13 | Sat | 2021-10-30 | 16:00 | Huesca | 1.1 | 1–1 | 0.6 | Amorebieta | 6,016 | Estadio El Alcoraz | Alejandro Quintero | Match Report | |
| 13 | Sat | 2021-10-30 | 18:15 | Lugo | 2.3 | 1–1 | 1.2 | Sporting Gijón | 5,069 | Estadio Anxo Carro | David Gálvez | Match Report | |
| 13 | Sat | 2021-10-30 | 21:00 | Cartagena | 0.7 | 0–1 | 2.0 | Ponferradina | 6,242 | Estadio Municipal Cartagonova | Javier Villanueva | Match Report | |
| 13 | Sun | 2021-10-31 | 14:00 | Fuenlabrada | 1.6 | 1–2 | 2.3 | Girona | 1,627 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| 13 | Sun | 2021-10-31 | 16:00 | Oviedo | 1.4 | 2–1 | 0.9 | Málaga | 8,369 | Estadio Nuevo Carlos Tartiere | Saúl Ais | Match Report | |
| 13 | Sun | 2021-10-31 | 18:15 | Valladolid | 1.3 | 2–0 | 1.6 | Eibar | 13,322 | Estadio Municipal José Zorrilla | Francisco Hernández | Match Report | |
| 13 | Sun | 2021-10-31 | 20:30 | Zaragoza | 1.4 | 1–1 | 1.6 | CD Mirandés | 13,802 | Estadio de la Romareda | Gorka Sagues | Match Report | |
| 13 | Mon | 2021-11-01 | 16:00 | Alcorcón | 0.3 | 0–2 | 0.9 | Ibiza | 1,522 | Estadio Santo Domingo | Víctor García Verdura | Match Report | |
| 13 | Mon | 2021-11-01 | 17:15 | Tenerife | 3.0 | 4–0 | 0.6 | Burgos | 12,105 | Estadio Heliodoro Rodríguez Lopéz | José López | Match Report | |
| 14 | Tue | 2021-11-02 | 19:00 | Sporting Gijón | 0.9 | 0–1 | 1.8 | Almería | 11,980 | Estadio Municipal El Molinón | Álvaro Moreno | Match Report | |
| 14 | Tue | 2021-11-02 | 19:00 | Ponferradina | 1.2 | 1–1 | 1.0 | Huesca | 3,524 | Estadio El Toralín | Rubén Ávalos | Match Report | |
| 14 | Tue | 2021-11-02 | 21:15 | Leganés | 1.7 | 1–1 | 0.9 | Cartagena | 4,767 | Estadio Municipal de Butarque | Eduardo Prieto | Match Report | |
| 14 | Wed | 2021-11-03 | 19:00 | Amorebieta | 2.9 | 4–1 | 1.5 | Valladolid | 913 | Instalaciones de Lezama Campo 2 | Iván Caparrós | Match Report | |
| 14 | Wed | 2021-11-03 | 19:00 | CD Mirandés | 2.3 | 3–2 | 1.2 | Lugo | 2,173 | Estadio Municipal de Anduva | Raúl González | Match Report | |
| 14 | Wed | 2021-11-03 | 20:15 | Las Palmas | 2.4 | 2–1 | 0.9 | Fuenlabrada | 8,714 | Estadio de Gran Canaria | Luis Milla | Match Report | |
| 14 | Wed | 2021-11-03 | 21:15 | Eibar | 0.6 | 1–0 | 0.5 | Oviedo | 3,551 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | |
| 14 | Thu | 2021-11-04 | 19:00 | Girona | 1.8 | 3–1 | 1.6 | Alcorcón | 4,419 | Estadi Municipal de Montilivi | Rafael Sánchez | Match Report | |
| 14 | Thu | 2021-11-04 | 19:00 | Burgos | 1.2 | 0–1 | 0.7 | Zaragoza | 9,584 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report | |
| 14 | Thu | 2021-11-04 | 21:15 | Málaga | 1.1 | 2–1 | 1.4 | Real Sociedad B | 12,130 | Estadio La Rosaleda | Oliver De La Fuente | Match Report | |
| 14 | Thu | 2021-11-04 | 21:15 | Ibiza | 0.5 | 0–0 | 0.8 | Tenerife | 3,501 | Estadio Municipal de Can Misses | Jon González | Match Report | |
| 15 | Fri | 2021-11-05 | 21:00 | Huesca | 0.8 | 0–2 | 0.9 | Leganés | 5,504 | Estadio El Alcoraz | José López | Match Report | |
| 15 | Sat | 2021-11-06 | 16:00 | Lugo | 1.4 | 1–2 | 1.8 | Ponferradina | 2,828 | Estadio Anxo Carro | Alejandro Quintero | Match Report | |
| 15 | Sat | 2021-11-06 | 18:15 | Valladolid | 2.1 | 3–1 | 2.1 | CD Mirandés | 14,267 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| 15 | Sat | 2021-11-06 | 18:15 | Oviedo | 1.5 | 1–1 | 1.4 | Las Palmas | 9,139 | Estadio Carlos Tartiere | Francisco Hernández | Match Report | |
| 15 | Sat | 2021-11-06 | 21:00 | Fuenlabrada | 1.1 | 0–0 | 1.1 | Eibar | 1,985 | Estadio Fernando Torres | Víctor García Verdura | Match Report | |
| 15 | Sun | 2021-11-07 | 14:00 | Alcorcón | 1.8 | 2–2 | 0.2 | Amorebieta | 1,147 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| 15 | Sun | 2021-11-07 | 16:00 | Zaragoza | 1.0 | 2–0 | 1.0 | Sporting Gijón | 18,100 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| 15 | Sun | 2021-11-07 | 18:15 | Cartagena | 1.5 | 3–1 | 1.0 | Málaga | 7,591 | Estadio Municipal Cartagonova | Dámaso Arcediano | Match Report | |
| 15 | Sun | 2021-11-07 | 18:15 | Almería | 1.3 | 2–0 | 0.2 | Burgos | 9,513 | Estadio de los Juegos Mediterráneos | Aitor Gorostegui | Match Report | |
| 15 | Sun | 2021-11-07 | 21:00 | Real Sociedad B | 0.4 | 0–1 | 0.8 | Ibiza | 845 | Estadio Municipal de Anoeta | Iosu Galech | Match Report | |
| 15 | Mon | 2021-11-08 | 20:00 | Tenerife | 0.8 | 2–1 | 0.9 | Girona | 10,121 | Estadio Heliodoro Rodríguez Lopéz | Gorka Sagues | Match Report | |
| 16 | Fri | 2021-11-12 | 21:00 | Sporting Gijón | 1.1 | 0–1 | 1.3 | Real Sociedad B | 12,452 | Estadio Municipal El Molinón | Raúl González | Match Report | |
| 16 | Sat | 2021-11-13 | 16:00 | Valladolid | 2.0 | 3–0 | 0.7 | Fuenlabrada | 14,105 | Estadio Municipal José Zorrilla | Rubén Ávalos | Match Report | |
| 16 | Sat | 2021-11-13 | 18:15 | CD Mirandés | 0.8 | 0–1 | 1.6 | Huesca | 2,700 | Estadio Municipal de Anduva | Juan Pulido | Match Report | |
| 16 | Sat | 2021-11-13 | 18:15 | Eibar | 1.2 | 2–1 | 1.7 | Alcorcón | 4,613 | Estadio Municipal de Ipurúa | Oliver De La Fuente | Match Report | |
| 16 | Sat | 2021-11-13 | 19:30 | Las Palmas | 2.0 | 2–3 | 1.7 | Zaragoza | 13,432 | Estadio de Gran Canaria | Álvaro Moreno | Match Report | |
| 16 | Sun | 2021-11-14 | 14:00 | Amorebieta | 0.6 | 1–3 | 0.4 | Lugo | 815 | Instalaciones de Lezama Campo 2 | Luis Milla | Match Report | |
| 16 | Sun | 2021-11-14 | 16:00 | Ibiza | 1.1 | 0–1 | 2.1 | Almería | 4,937 | Estadio Municipal de Can Misses | Eduardo Prieto | Match Report | |
| 16 | Sun | 2021-11-14 | 16:00 | Girona | 3.1 | 2–0 | 0.9 | Cartagena | 6,055 | Estadi Municipal de Montilivi | David Gálvez | Match Report | |
| 16 | Sun | 2021-11-14 | 18:15 | Burgos | 0.8 | 1–0 | 1.5 | Ponferradina | 7,495 | Estadio Municipal de El Plantío | Iván Caparrós | Match Report | |
| 16 | Sun | 2021-11-14 | 18:15 | Leganés | 1.0 | 0–0 | 0.5 | Oviedo | 7,803 | Estadio Municipal de Butarque | Javier Villanueva | Match Report | |
| 16 | Mon | 2021-11-15 | 21:00 | Málaga | 1.3 | 1–0 | 1.1 | Tenerife | 15,700 | Estadio La Rosaleda | Rafael Sánchez | Match Report | |
| 17 | Fri | 2021-11-19 | 21:00 | Fuenlabrada | 0.5 | 1–1 | 1.4 | CD Mirandés | 2,607 | Estadio Fernando Torres | Iosu Galech | Match Report | |
| 17 | Sat | 2021-11-20 | 16:00 | Oviedo | 2.3 | 2–0 | 0.4 | Amorebieta | 8,473 | Estadio Carlos Tartiere | Víctor García Verdura | Match Report | |
| 17 | Sat | 2021-11-20 | 18:15 | Málaga | 1.2 | 2–1 | 1.3 | Las Palmas | 22,128 | Estadio La Rosaleda | Eduardo Prieto | Match Report | |
| 17 | Sat | 2021-11-20 | 20:30 | Almería | 1.8 | 3–1 | 0.5 | Valladolid | 9,208 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| 17 | Sun | 2021-11-21 | 14:00 | Cartagena | 2.8 | 1–0 | 0.5 | Burgos | 5,476 | Estadio Municipal Cartagonova | Gorka Sagues | Match Report | |
| 17 | Sun | 2021-11-21 | 16:00 | Lugo | 0.8 | 2–2 | 2.6 | Eibar | 2,709 | Estadio Anxo Carro | Saúl Ais | Match Report | |
| 17 | Sun | 2021-11-21 | 17:15 | Tenerife | 0.6 | 1–0 | 0.5 | Alcorcón | 11,810 | Estadio Heliodoro Rodríguez Lopéz | Alejandro Quintero | Match Report | |
| 17 | Sun | 2021-11-21 | 18:15 | Huesca | 1.8 | 0–0 | 1.2 | Ibiza | 6,164 | Estadio El Alcoraz | Aitor Gorostegui | Match Report | |
| 17 | Sun | 2021-11-21 | 20:30 | Ponferradina | 2.1 | 4–1 | 0.8 | Sporting Gijón | 5,250 | Estadio El Toralín | José López | Match Report | |
| 17 | Mon | 2021-11-22 | 19:00 | Real Sociedad B | 1.2 | 1–2 | 1.3 | Girona | 1,898 | Estadio Municipal de Anoeta | Francisco Hernández | Match Report | |
| 17 | Mon | 2021-11-22 | 21:00 | Zaragoza | 0.5 | 0–2 | 0.9 | Leganés | 10,426 | Estadio de la Romareda | Dámaso Arcediano | Match Report | |
| 18 | Fri | 2021-11-26 | 21:00 | CD Mirandés | 1.7 | 1–1 | 0.2 | Oviedo | 2,208 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| 18 | Fri | 2021-11-26 | 21:00 | Alcorcón | 1.2 | 1–1 | 1.4 | Lugo | 1,042 | Estadio Santo Domingo | Raúl González | Match Report | |
| 18 | Sat | 2021-11-27 | 16:00 | Burgos | 2.0 | 3–0 | 0.6 | Málaga | 7,246 | Estadio Municipal de El Plantío | Juan Pulido | Match Report | |
| 18 | Sat | 2021-11-27 | 18:15 | Almería | 1.7 | 0–0 | 0.5 | Huesca | 9,486 | Estadio de los Juegos Mediterráneos | David Gálvez | Match Report | |
| 18 | Sat | 2021-11-27 | 18:15 | Sporting Gijón | 1.1 | 1–1 | 0.4 | Fuenlabrada | 8,989 | Estadio Municipal El Molinón | Francisco Hernández | Match Report | |
| 18 | Sat | 2021-11-27 | 20:30 | Valladolid | 2.5 | 2–0 | 0.7 | Cartagena | 11,314 | Estadio Municipal José Zorrilla | Álvaro Moreno | Match Report | |
| 18 | Sun | 2021-11-28 | 14:00 | Leganés | 2.0 | 4–1 | 0.6 | Las Palmas | 7,008 | Estadio Municipal de Butarque | Rubén Ávalos | Match Report | |
| 18 | Sun | 2021-11-28 | 16:00 | Amorebieta | 0.4 | 1–1 | 1.2 | Zaragoza | 1,250 | Instalaciones de Lezama Campo 2 | Oliver De La Fuente | Match Report | |
| 18 | Sun | 2021-11-28 | 16:00 | Ibiza | 0.8 | 0–1 | 1.6 | Ponferradina | 3,971 | Estadio Municipal de Can Misses | Luis Milla | Match Report | |
| 18 | Sun | 2021-11-28 | 17:15 | Tenerife | 1.5 | 2–0 | 1.3 | Real Sociedad B | 9,850 | Estadio Heliodoro Rodríguez Lopéz | José López | Match Report | |
| 18 | Mon | 2021-11-29 | 21:00 | Eibar | 1.1 | 4–2 | 1.3 | Girona | 3,200 | Estadio Municipal de Ipurúa | Iván Caparrós | Match Report | |
| 19 | Fri | 2021-12-03 | 21:00 | Huesca | 1.3 | 3–2 | 2.2 | Valladolid | 4,218 | Estadio El Alcoraz | Saúl Ais | Match Report | |
| 19 | Sat | 2021-12-04 | 18:15 | Fuenlabrada | 0.6 | 1–1 | 0.9 | Almería | 2,052 | Estadio Fernando Torres | Juan Pulido | Match Report | |
| 19 | Sun | 2021-12-05 | 14:00 | Ponferradina | 1.0 | 2–1 | 1.8 | CD Mirandés | 4,098 | Estadio El Toralín | Aitor Gorostegui | Match Report | |
| 19 | Sun | 2021-12-05 | 16:00 | Málaga | 0.5 | 1–2 | 0.8 | Amorebieta | 18,980 | Estadio La Rosaleda | Daniel Trujillo | Match Report | |
| 19 | Sun | 2021-12-05 | 18:15 | Real Sociedad B | 0.7 | 0–1 | 0.9 | Burgos | 3,586 | Estadio Municipal de Anoeta | Alejandro Quintero | Match Report | |
| 19 | Sun | 2021-12-05 | 18:15 | Lugo | 0.9 | 0–0 | 0.3 | Ibiza | 2,360 | Estadio Anxo Carro | Víctor García Verdura | Match Report | |
| 19 | Sun | 2021-12-05 | 18:15 | Oviedo | 1.6 | 3–1 | 0.4 | Alcorcón | 7,102 | Estadio Carlos Tartiere | Gorka Sagues | Match Report | |
| 19 | Sun | 2021-12-05 | 19:30 | Las Palmas | 1.7 | 1–0 | 0.6 | Sporting Gijón | 11,539 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| 19 | Mon | 2021-12-06 | 16:00 | Zaragoza | 1.1 | 1–0 | 1.4 | Eibar | 16,109 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| 19 | Mon | 2021-12-06 | 18:15 | Cartagena | 1.5 | 1–1 | 1.1 | Tenerife | 7,441 | Estadio Municipal Cartagonova | Iosu Galech | Match Report | |
| 19 | Mon | 2021-12-06 | 21:00 | Girona | 1.4 | 3–0 | 0.7 | Leganés | 5,190 | Estadi Municipal de Montilivi | Eduardo Prieto | Match Report | |
| 20 | Fri | 2021-12-10 | 21:00 | Sporting Gijón | 1.3 | 1–1 | 1.1 | Huesca | 9,680 | Estadio Municipal El Molinón | Daniel Trujillo | Match Report | |
| 20 | Sat | 2021-12-11 | 16:00 | Burgos | 1.4 | 2–0 | 0.8 | Fuenlabrada | 8,107 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| 20 | Sat | 2021-12-11 | 16:00 | Ibiza | 2.1 | 1–1 | 2.0 | Girona | 4,087 | Estadio Municipal de Can Misses | Oliver De La Fuente | Match Report | |
| 20 | Sat | 2021-12-11 | 18:15 | Almería | 3.0 | 3–0 | 0.6 | Zaragoza | 9,258 | Estadio de los Juegos Mediterráneos | Francisco Hernández | Match Report | |
| 20 | Sat | 2021-12-11 | 20:00 | Tenerife | 1.1 | 1–1 | 2.1 | Lugo | 9,617 | Estadio Heliodoro Rodríguez Lopéz | David Gálvez | Match Report | |
| 20 | Sat | 2021-12-11 | 20:30 | Eibar | 2.1 | 2–2 | 1.4 | Málaga | 3,921 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| 20 | Sun | 2021-12-12 | 14:00 | Leganés | 0.6 | 1–1 | 1.7 | Ponferradina | 7,117 | Estadio Municipal de Butarque | Raúl González | Match Report | |
| 20 | Sun | 2021-12-12 | 16:00 | Valladolid | 0.9 | 2–1 | 1.7 | Oviedo | 15,309 | Estadio Municipal José Zorrilla | José López | Match Report | |
| 20 | Sun | 2021-12-12 | 18:15 | Amorebieta | 1.6 | 1–1 | 1.0 | Las Palmas | 1,097 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| 20 | Sun | 2021-12-12 | 18:15 | Alcorcón | 0.7 | 1–1 | 1.5 | Cartagena | 1,427 | Estadio Santo Domingo | Luis Milla | Match Report | |
| 20 | Mon | 2021-12-13 | 21:00 | CD Mirandés | 1.8 | 2–0 | 0.4 | Real Sociedad B | 2,170 | Estadio Municipal de Anduva | Iván Caparrós | Match Report | |
| 21 | Fri | 2021-12-17 | 21:00 | Girona | 2.4 | 3–1 | 1.3 | Burgos | 4,248 | Estadi Municipal de Montilivi | Saúl Ais | Match Report | |
| 21 | Sat | 2021-12-18 | 16:00 | Ibiza | 2.6 | 0–2 | 1.5 | Sporting Gijón | 3,789 | Estadio Municipal de Can Misses | Iosu Galech | Match Report | |
| 21 | Sat | 2021-12-18 | 16:00 | Málaga | 0.3 | 0–2 | 1.9 | Leganés | 14,571 | Estadio La Rosaleda | Javier Villanueva | Match Report | |
| 21 | Sat | 2021-12-18 | 17:15 | Las Palmas | 1.2 | 0–1 | 0.8 | Eibar | 10,331 | Estadio de Gran Canaria | Eduardo Prieto | Match Report | |
| 21 | Sun | 2021-12-19 | 14:00 | Fuenlabrada | 0.9 | 0–0 | 1.3 | Oviedo | 2,127 | Estadio Fernando Torres | Aitor Gorostegui | Match Report | |
| 21 | Sun | 2021-12-19 | 16:00 | Ponferradina | 0.9 | 1–1 | 0.8 | Amorebieta | 5,432 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| 21 | Sun | 2021-12-19 | 16:00 | Zaragoza | 1.5 | 0–2 | 0.5 | Tenerife | 15,283 | Estadio de la Romareda | Alejandro Quintero | Match Report | |
| 21 | Sun | 2021-12-19 | 18:15 | Huesca | 0.6 | 0–0 | 0.5 | Alcorcón | 4,588 | Estadio El Alcoraz | Víctor García Verdura | Match Report | |
| 21 | Sun | 2021-12-19 | 18:15 | Real Sociedad B | 0.7 | 0–2 | 3.5 | Valladolid | 2,582 | Estadio Municipal de Anoeta | Alexis Carlos Pulido | Match Report | |
| 21 | Sun | 2021-12-19 | 18:15 | Cartagena | 1.6 | 3–0 | 0.7 | CD Mirandés | 5,631 | Estadio Municipal Cartagonova | Jon González | Match Report | |
| 22 | Fri | 2021-12-31 | 14:00 | Oviedo | 2.5 | 2–0 | 0.5 | Ponferradina | 7,125 | Estadio Carlos Tartiere | David Gálvez | Match Report | |
| 22 | Fri | 2021-12-31 | 16:00 | Burgos | 1.3 | 2–2 | 1.5 | Amorebieta | 10,277 | Estadio Municipal de El Plantío | José López | Match Report | |
| 22 | Fri | 2021-12-31 | 16:15 | Eibar | 1.2 | 3–2 | 2.0 | Real Sociedad B | 4,105 | Estadio Municipal de Ipurúa | Oliver De La Fuente | Match Report | |
| 22 | Sun | 2022-01-02 | 14:00 | Almería | 1.1 | 0–1 | 1.5 | Cartagena | 7,058 | Estadio de los Juegos Mediterráneos | Raúl González | Match Report | |
| 22 | Sun | 2022-01-02 | 14:00 | Valladolid | 2.0 | 1–0 | 0.8 | Leganés | 11,700 | Estadio Municipal José Zorrilla | Daniel Trujillo | Match Report | |
| 22 | Sun | 2022-01-02 | 16:00 | Sporting Gijón | 1.1 | 1–1 | 1.5 | Lugo | 12,462 | Estadio Municipal El Molinón | Rubén Ávalos | Match Report | |
| 22 | Sun | 2022-01-02 | 18:15 | CD Mirandés | 1.8 | 2–0 | 0.6 | Zaragoza | 3,076 | Estadio Municipal de Anduva | Luis Milla | Match Report | |
| 22 | Sun | 2022-01-02 | 18:15 | Huesca | 1.3 | 0–1 | 0.6 | Girona | 4,995 | Estadio El Alcoraz | Álvaro Moreno | Match Report | |
| 22 | Sun | 2022-01-02 | 20:30 | Tenerife | 1.1 | 0–1 | 0.7 | Las Palmas | 10,756 | Estadio Heliodoro Rodríguez Lopéz | Jon González | Match Report | |
| 22 | Sun | 2022-01-02 | 21:00 | Fuenlabrada | 2.1 | 1–2 | 2.5 | Ibiza | 2,037 | Estadio Fernando Torres | Iván Caparrós | Match Report | |
| 22 | Mon | 2022-01-03 | 21:00 | Alcorcón | 0.8 | 0–1 | 0.4 | Málaga | 1,111 | Estadio Santo Domingo | Rafael Sánchez | Match Report | |
| 23 | Fri | 2022-01-07 | 21:00 | Amorebieta | 0.3 | 1–1 | 2.6 | Tenerife | 764 | Instalaciones de Lezama Campo 2 | Víctor García Verdura | Match Report | |
| 23 | Sat | 2022-01-08 | 16:00 | Cartagena | 1.1 | 0–3 | 2.6 | Huesca | 6,596 | Estadio Municipal Cartagonova | Eduardo Prieto | Match Report | |
| 23 | Sat | 2022-01-08 | 16:00 | Ibiza | 3.4 | 6–2 | 1.7 | Alcorcón | 3,337 | Estadio Municipal de Can Misses | Francisco Hernández | Match Report | |
| 23 | Sat | 2022-01-08 | 18:15 | Valladolid | 1.7 | 1–0 | 0.3 | Burgos | 15,566 | Estadio Municipal José Zorrilla | Javier Villanueva | Match Report | |
| 23 | Sat | 2022-01-08 | 21:00 | Leganés | 1.5 | 1–1 | 0.4 | Real Sociedad B | 4,828 | Estadio Municipal de Butarque | Saúl Ais | Match Report | |
| 23 | Sun | 2022-01-09 | 14:00 | Girona | 1.3 | 2–1 | 0.4 | Fuenlabrada | 5,163 | Estadi Municipal de Montilivi | Alejandro Quintero | Match Report | |
| 23 | Sun | 2022-01-09 | 16:00 | Lugo | 1.8 | 2–1 | 1.9 | CD Mirandés | 1,896 | Estadio Anxo Carro | Dámaso Arcediano | Match Report | |
| 23 | Sun | 2022-01-09 | 18:15 | Málaga | 2.1 | 2–2 | 1.8 | Sporting Gijón | 14,470 | Estadio La Rosaleda | Gorka Sagues | Match Report | |
| 23 | Sun | 2022-01-09 | 20:30 | Las Palmas | 1.6 | 1–1 | 0.4 | Almería | 9,827 | Estadio de Gran Canaria | David Gálvez | Match Report | |
| 23 | Sun | 2022-01-09 | 20:30 | Ponferradina | 1.0 | 0–0 | 0.5 | Zaragoza | 3,282 | Estadio El Toralín | Iosu Galech | Match Report | |
| 23 | Mon | 2022-01-10 | 21:00 | Oviedo | 1.1 | 1–1 | 0.9 | Eibar | 7,614 | Estadio Carlos Tartiere | Juan Pulido | Match Report | |
| 21 | Wed | 2022-01-19 | 21:00 | Lugo | 1.4 | 2–1 | 1.5 | Almería | 1,445 | Estadio Anxo Carro | Gorka Sagues | Match Report | |
| 24 | Fri | 2022-01-21 | 20:00 | Tenerife | 2.4 | 4–0 | 0.6 | Oviedo | 7,319 | Estadio Heliodoro Rodríguez Lopéz | Oliver De La Fuente | Match Report | |
| 24 | Sat | 2022-01-22 | 16:00 | Zaragoza | 0.7 | 0–0 | 0.7 | Valladolid | 14,795 | Estadio de la Romareda | Jon González | Match Report | |
| 24 | Sat | 2022-01-22 | 18:15 | Fuenlabrada | 2.1 | 3–2 | 2.1 | Las Palmas | 2,554 | Estadio Fernando Torres | Francisco Hernández | Match Report | |
| 24 | Sat | 2022-01-22 | 21:00 | Málaga | 1.8 | 0–5 | 1.4 | Ibiza | 15,003 | Estadio La Rosaleda | Raúl González | Match Report | |
| 24 | Sun | 2022-01-23 | 14:00 | Burgos | 1.9 | 4–0 | 0.4 | Leganés | 8,362 | Estadio Municipal de El Plantío | Rubén Ávalos | Match Report | |
| 24 | Sun | 2022-01-23 | 16:00 | Sporting Gijón | 1.4 | 2–1 | 1.1 | Amorebieta | 12,970 | Estadio Municipal El Molinón | Rafael Sánchez | Match Report | |
| 24 | Sun | 2022-01-23 | 18:15 | Huesca | 1.3 | 1–2 | 1.5 | Ponferradina | 5,109 | Estadio El Alcoraz | Iván Caparrós | Match Report | |
| 24 | Sun | 2022-01-23 | 18:15 | Girona | 2.0 | 1–1 | 1.4 | Lugo | 5,580 | Estadi Municipal de Montilivi | Aitor Gorostegui | Match Report | |
| 24 | Sun | 2022-01-23 | 21:00 | Alcorcón | 0.8 | 0–0 | 0.5 | CD Mirandés | 820 | Estadio Santo Domingo | José López | Match Report | |
| 24 | Mon | 2022-01-24 | 21:00 | Almería | 1.2 | 0–2 | 0.7 | Eibar | 7,843 | Estadio de los Juegos Mediterráneos | Daniel Trujillo | Match Report | |
| 24 | Mon | 2022-01-24 | 21:00 | Real Sociedad B | 1.7 | 1–2 | 2.0 | Cartagena | 985 | Estadio Municipal de Anoeta | Álvaro Moreno | Match Report | |
| 25 | Fri | 2022-01-28 | 21:00 | Valladolid | 2.3 | 1–0 | 0.3 | Sporting Gijón | 13,221 | Estadio Municipal José Zorrilla | Luis Milla | Match Report | |
| 25 | Sat | 2022-01-29 | 16:00 | Amorebieta | 0.8 | 1–0 | 0.4 | Girona | 954 | Instalaciones de Lezama Campo 2 | Eduardo Prieto | Match Report | |
| 25 | Sat | 2022-01-29 | 18:15 | Lugo | 1.8 | 1–0 | 0.6 | Burgos | 2,836 | Estadio Anxo Carro | Jon González | Match Report | |
| 25 | Sat | 2022-01-29 | 18:15 | Eibar | 1.8 | 2–1 | 1.9 | Huesca | 5,121 | Estadio Municipal de Ipurúa | Dámaso Arcediano | Match Report | |
| 25 | Sat | 2022-01-29 | 21:00 | Oviedo | 0.4 | 2–0 | 0.8 | Almería | 10,543 | Estadio Carlos Tartiere | Javier Villanueva | Match Report | |
| 25 | Sun | 2022-01-30 | 14:00 | Leganés | 1.2 | 1–0 | 1.2 | Alcorcón | 7,341 | Estadio Municipal de Butarque | Iosu Galech | Match Report | |
| 25 | Sun | 2022-01-30 | 16:00 | Cartagena | 2.8 | 3–0 | 0.7 | Fuenlabrada | 7,514 | Estadio Municipal Cartagonova | Juan Pulido | Match Report | |
| 25 | Sun | 2022-01-30 | 17:15 | Las Palmas | 1.1 | 0–0 | 1.5 | Real Sociedad B | 11,030 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| 25 | Sun | 2022-01-30 | 18:15 | CD Mirandés | 2.0 | 3–0 | 0.6 | Málaga | 2,567 | Estadio Municipal de Anduva | Víctor García Verdura | Match Report | |
| 25 | Sun | 2022-01-30 | 21:00 | Ponferradina | 0.9 | 1–2 | 2.1 | Tenerife | 3,963 | Estadio El Toralín | Gorka Sagues | Match Report | |
| 25 | Mon | 2022-01-31 | 21:00 | Ibiza | 1.0 | 2–2 | 1.8 | Zaragoza | 4,678 | Estadio Municipal de Can Misses | Saúl Ais | Match Report | |
| 26 | Fri | 2022-02-04 | 21:00 | Almería | 3.6 | 2–0 | 0.2 | Ibiza | 7,993 | Estadio de los Juegos Mediterráneos | Álvaro Moreno | Match Report | |
| 26 | Fri | 2022-02-04 | 21:00 | Burgos | 1.4 | 3–1 | 0.9 | Alcorcón | 3,380 | Estadio Municipal de El Plantío | Raúl González | Match Report | |
| 26 | Sat | 2022-02-05 | 16:00 | Real Sociedad B | 2.2 | 1–1 | 1.3 | Lugo | 5,356 | Estadio Municipal de Anoeta | Daniel Trujillo | Match Report | |
| 26 | Sat | 2022-02-05 | 18:15 | Zaragoza | 2.1 | 1–1 | 0.5 | Málaga | 16,178 | Estadio de la Romareda | Francisco Hernández | Match Report | |
| 26 | Sat | 2022-02-05 | 20:30 | Girona | 1.0 | 3–0 | 1.0 | Ponferradina | 5,675 | Estadi Municipal de Montilivi | Rafael Sánchez | Match Report | |
| 26 | Sat | 2022-02-05 | 20:30 | Sporting Gijón | 0.7 | 0–1 | 1.1 | Eibar | 15,575 | Estadio Municipal El Molinón | José López | Match Report | |
| 26 | Sun | 2022-02-06 | 14:00 | Amorebieta | 1.5 | 1–1 | 0.7 | Oviedo | 1,415 | Instalaciones de Lezama Campo 2 | Iván Caparrós | Match Report | |
| 26 | Sun | 2022-02-06 | 14:00 | Fuenlabrada | 0.6 | 0–0 | 1.5 | Valladolid | 3,402 | Estadio Fernando Torres | Rubén Ávalos | Match Report | |
| 26 | Sun | 2022-02-06 | 18:15 | Cartagena | 0.5 | 0–2 | 2.5 | Las Palmas | 9,382 | Estadio Municipal Cartagonova | Oliver De La Fuente | Match Report | |
| 26 | Sun | 2022-02-06 | 18:15 | Huesca | 2.9 | 4–0 | 0.4 | CD Mirandés | 5,434 | Estadio El Alcoraz | David Gálvez | Match Report | |
| 26 | Sun | 2022-02-06 | 20:00 | Tenerife | 1.6 | 0–0 | 0.3 | Leganés | 11,040 | Estadio Heliodoro Rodríguez Lopéz | Aitor Gorostegui | Match Report | |
| 27 | Fri | 2022-02-11 | 21:00 | Leganés | 0.9 | 2–1 | 1.3 | Zaragoza | 8,244 | Estadio Municipal de Butarque | Dámaso Arcediano | Match Report | |
| 27 | Sat | 2022-02-12 | 16:00 | CD Mirandés | 0.8 | 0–3 | 2.1 | Sporting Gijón | 2,795 | Estadio Municipal de Anduva | Eduardo Prieto | Match Report | |
| 27 | Sat | 2022-02-12 | 18:15 | Valladolid | 2.6 | 2–2 | 2.1 | Girona | 14,570 | Estadio Municipal José Zorrilla | Juan Pulido | Match Report | |
| 27 | Sat | 2022-02-12 | 18:15 | Ibiza | 2.4 | 2–1 | 0.9 | Cartagena | 4,408 | Estadio Municipal de Can Misses | Alejandro Quintero | Match Report | |
| 27 | Sat | 2022-02-12 | 20:30 | Málaga | 0.4 | 0–1 | 1.2 | Almería | 17,267 | Estadio La Rosaleda | Jon González | Match Report | |
| 27 | Sun | 2022-02-13 | 14:00 | Eibar | 0.9 | 0–0 | 1.0 | Fuenlabrada | 4,633 | Estadio Municipal de Ipurúa | Javier Villanueva | Match Report | |
| 27 | Sun | 2022-02-13 | 16:00 | Oviedo | 1.8 | 3–3 | 3.7 | Huesca | 10,608 | Estadio Carlos Tartiere | Iosu Galech | Match Report | |
| 27 | Sun | 2022-02-13 | 18:15 | Lugo | 0.6 | 1–1 | 1.1 | Amorebieta | 2,262 | Estadio Anxo Carro | Luis Milla | Match Report | |
| 27 | Sun | 2022-02-13 | 18:15 | Alcorcón | 0.5 | 0–2 | 0.3 | Tenerife | 2,425 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| 27 | Sun | 2022-02-13 | 20:00 | Las Palmas | 2.0 | 0–2 | 0.7 | Burgos | 9,803 | Estadio de Gran Canaria | Gorka Sagues | Match Report | |
| 27 | Mon | 2022-02-14 | 21:00 | Ponferradina | 1.5 | 3–2 | 1.2 | Real Sociedad B | 3,300 | Estadio El Toralín | Víctor García Verdura | Match Report | |
| 28 | Fri | 2022-02-18 | 21:00 | Cartagena | 1.3 | 2–3 | 2.2 | Valladolid | 6,963 | Estadio Municipal Cartagonova | Daniel Trujillo | Match Report | |
| 28 | Sat | 2022-02-19 | 16:00 | Zaragoza | 0.8 | 2–1 | 2.1 | Las Palmas | 14,989 | Estadio de la Romareda | Iván Caparrós | Match Report | |
| 28 | Sat | 2022-02-19 | 17:15 | Tenerife | 1.1 | 2–0 | 1.6 | Ibiza | 13,087 | Estadio Heliodoro Rodríguez Lopéz | Rubén Ávalos | Match Report | |
| 28 | Sat | 2022-02-19 | 18:15 | Girona | 0.7 | 0–1 | 0.5 | Eibar | 6,551 | Estadi Municipal de Montilivi | Oliver De La Fuente | Match Report | |
| 28 | Sat | 2022-02-19 | 21:00 | Real Sociedad B | 0.8 | 2–0 | 0.9 | Málaga | 4,661 | Estadio Municipal de Anoeta | José López | Match Report | |
| 28 | Sun | 2022-02-20 | 14:00 | Fuenlabrada | 2.5 | 2–2 | 1.2 | Alcorcón | 3,328 | Estadio Fernando Torres | Rafael Sánchez | Match Report | |
| 28 | Sun | 2022-02-20 | 16:00 | Burgos | 2.0 | 0–1 | 1.5 | Oviedo | 9,935 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| 28 | Sun | 2022-02-20 | 18:15 | Huesca | 2.5 | 1–0 | 0.7 | Lugo | 6,097 | Estadio El Alcoraz | Álvaro Moreno | Match Report | |
| 28 | Sun | 2022-02-20 | 18:15 | Sporting Gijón | 2.6 | 2–3 | 1.9 | Ponferradina | 16,480 | Estadio Municipal El Molinón | Francisco Hernández | Match Report | |
| 28 | Sun | 2022-02-20 | 21:00 | Almería | 2.3 | 2–1 | 2.2 | CD Mirandés | 8,432 | Estadio de los Juegos Mediterráneos | Aitor Gorostegui | Match Report | |
| 28 | Mon | 2022-02-21 | 21:00 | Amorebieta | 0.7 | 1–3 | 0.8 | Leganés | 860 | Instalaciones de Lezama Campo 2 | Raúl González | Match Report | |
| 29 | Fri | 2022-02-25 | 21:00 | Almería | 3.1 | 3–1 | 0.9 | Fuenlabrada | 8,506 | Estadio de los Juegos Mediterráneos | Víctor García Verdura | Match Report | |
| 29 | Sat | 2022-02-26 | 16:00 | Ibiza | 2.0 | 2–1 | 2.0 | Huesca | 4,263 | Estadio Municipal de Can Misses | Gorka Sagues | Match Report | |
| 29 | Sat | 2022-02-26 | 16:00 | CD Mirandés | 1.6 | 2–1 | 1.4 | Tenerife | 2,652 | Estadio Municipal de Anduva | Dámaso Arcediano | Match Report | |
| 29 | Sat | 2022-02-26 | 18:15 | Oviedo | 1.4 | 0–1 | 1.5 | Real Sociedad B | 10,486 | Estadio Carlos Tartiere | Luis Milla | Match Report | |
| 29 | Sat | 2022-02-26 | 20:00 | Las Palmas | 2.0 | 2–2 | 0.9 | Lugo | 6,675 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| 29 | Sun | 2022-02-27 | 14:00 | Eibar | 1.2 | 2–0 | 1.2 | Burgos | 5,135 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | |
| 29 | Sun | 2022-02-27 | 16:00 | Sporting Gijón | 2.4 | 1–2 | 2.0 | Zaragoza | 15,470 | Estadio Municipal El Molinón | Jon González | Match Report | |
| 29 | Sun | 2022-02-27 | 18:15 | Valladolid | 2.3 | 5–1 | 0.7 | Amorebieta | 14,108 | Estadio Municipal José Zorrilla | Iosu Galech | Match Report | |
| 29 | Sun | 2022-02-27 | 18:15 | Leganés | 1.3 | 1–1 | 0.8 | Girona | 7,457 | Estadio Municipal de Butarque | Javier Villanueva | Match Report | |
| 29 | Sun | 2022-02-27 | 21:00 | Alcorcón | 2.9 | 2–2 | 1.1 | Ponferradina | 1,237 | Estadio Santo Domingo | Eduardo Prieto | Match Report | |
| 29 | Mon | 2022-02-28 | 21:00 | Málaga | 1.2 | 1–1 | 1.2 | Cartagena | 13,782 | Estadio La Rosaleda | Saúl Ais | Match Report | |
| 30 | Fri | 2022-03-04 | 21:00 | Zaragoza | 0.9 | 2–0 | 1.9 | Almería | 14,000 | Estadio de la Romareda | Daniel Trujillo | Match Report | |
| 30 | Sat | 2022-03-05 | 16:00 | Huesca | 1.5 | 0–0 | 1.3 | Las Palmas | 6,084 | Estadio El Alcoraz | Aitor Gorostegui | Match Report | |
| 30 | Sat | 2022-03-05 | 16:00 | Fuenlabrada | 1.3 | 1–2 | 1.8 | Burgos | 3,188 | Estadio Fernando Torres | Iván Caparrós | Match Report | |
| 30 | Sat | 2022-03-05 | 17:15 | Tenerife | 2.0 | 1–4 | 1.8 | Valladolid | 18,538 | Estadio Heliodoro Rodríguez Lopéz | Francisco Hernández | Match Report | |
| 30 | Sun | 2022-03-06 | 14:00 | Lugo | 1.1 | 1–0 | 1.4 | Alcorcón | 1,861 | Estadio Anxo Carro | José López | Match Report | |
| 30 | Sun | 2022-03-06 | 16:00 | Ponferradina | 0.9 | 1–1 | 2.0 | Ibiza | 4,797 | Estadio El Toralín | David Gálvez | Match Report | |
| 30 | Sun | 2022-03-06 | 18:15 | Leganés | 2.4 | 2–0 | 1.3 | CD Mirandés | 8,213 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| 30 | Sun | 2022-03-06 | 18:15 | Amorebieta | 1.0 | 1–2 | 1.1 | Málaga | 997 | Instalaciones de Lezama Campo 2 | Álvaro Moreno | Match Report | |
| 30 | Sun | 2022-03-06 | 18:15 | Cartagena | 2.3 | 4–1 | 1.3 | Eibar | 5,097 | Estadio Municipal Cartagonova | Rubén Ávalos | Match Report | |
| 30 | Sun | 2022-03-06 | 21:00 | Girona | 1.0 | 2–1 | 1.3 | Oviedo | 4,313 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| 30 | Mon | 2022-03-07 | 21:00 | Real Sociedad B | 1.7 | 2–1 | 1.5 | Sporting Gijón | 3,032 | Estadio Municipal de Anoeta | Oliver De La Fuente | Match Report | |
| 31 | Fri | 2022-03-11 | 21:00 | Zaragoza | 1.3 | 2–1 | 0.2 | Fuenlabrada | 16,317 | Estadio de la Romareda | Eduardo Prieto | Match Report | |
| 31 | Sat | 2022-03-12 | 16:00 | CD Mirandés | 1.2 | 2–1 | 0.7 | Cartagena | 2,784 | Estadio Municipal de Anduva | Gorka Sagues | Match Report | |
| 31 | Sat | 2022-03-12 | 16:00 | Ibiza | 1.3 | 1–1 | 0.7 | Leganés | 4,326 | Estadio Municipal de Can Misses | Daniel Trujillo | Match Report | |
| 31 | Sat | 2022-03-12 | 17:15 | Las Palmas | 1.4 | 1–3 | 3.9 | Girona | 12,591 | Estadio de Gran Canaria | Dámaso Arcediano | Match Report | |
| 31 | Sat | 2022-03-12 | 18:15 | Almería | 1.9 | 3–3 | 0.6 | Lugo | 10,053 | Estadio de los Juegos Mediterráneos | Juan Pulido | Match Report | |
| 31 | Sat | 2022-03-12 | 21:00 | Málaga | 1.0 | 0–0 | 0.6 | Ponferradina | 11,378 | Estadio La Rosaleda | Víctor García Verdura | Match Report | |
| 31 | Sun | 2022-03-13 | 14:00 | Burgos | 0.6 | 0–0 | 0.7 | Real Sociedad B | 8,678 | Estadio Municipal de El Plantío | Alejandro Quintero | Match Report | |
| 31 | Sun | 2022-03-13 | 16:00 | Sporting Gijón | 1.2 | 1–2 | 1.7 | Tenerife | 14,002 | Estadio Municipal El Molinón | Luis Milla | Match Report | |
| 31 | Sun | 2022-03-13 | 16:00 | Eibar | 2.6 | 1–0 | 0.7 | Amorebieta | 5,741 | Estadio Municipal de Ipurúa | Saúl Ais | Match Report | |
| 31 | Sun | 2022-03-13 | 18:15 | Oviedo | 1.7 | 3–0 | 0.6 | Valladolid | 12,224 | Estadio Carlos Tartiere | Javier Villanueva | Match Report | |
| 31 | Sun | 2022-03-13 | 18:15 | Alcorcón | 1.3 | 1–0 | 0.5 | Huesca | 2,636 | Estadio Santo Domingo | Raúl González | Match Report | |
| 32 | Fri | 2022-03-18 | 21:00 | Huesca | 1.3 | 1–0 | 0.3 | Burgos | 4,395 | Estadio El Alcoraz | Francisco Hernández | Match Report | |
| 32 | Sat | 2022-03-19 | 14:00 | Real Sociedad B | 2.1 | 1–3 | 1.4 | CD Mirandés | 8,531 | Estadio Municipal de Anoeta | David Gálvez | Match Report | |
| 32 | Sat | 2022-03-19 | 16:00 | Fuenlabrada | 0.7 | 1–0 | 0.7 | Málaga | 2,988 | Estadio Fernando Torres | Jon González | Match Report | |
| 32 | Sat | 2022-03-19 | 16:00 | Cartagena | 1.6 | 3–0 | 0.4 | Zaragoza | 7,056 | Estadio Municipal Cartagonova | José López | Match Report | |
| 32 | Sat | 2022-03-19 | 18:15 | Valladolid | 1.6 | 0–1 | 1.3 | Las Palmas | 15,252 | Estadio Municipal José Zorrilla | Luis Milla | Match Report | |
| 32 | Sat | 2022-03-19 | 18:15 | Lugo | 0.9 | 1–1 | 1.2 | Oviedo | 4,283 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| 32 | Sat | 2022-03-19 | 21:00 | Girona | 1.9 | 5–1 | 1.3 | Ibiza | 4,827 | Estadi Municipal de Montilivi | Iosu Galech | Match Report | |
| 32 | Sun | 2022-03-20 | 14:00 | Amorebieta | 1.0 | 0–0 | 0.6 | Alcorcón | 688 | Instalaciones de Lezama Campo 2 | Rafael Sánchez | Match Report | |
| 32 | Sun | 2022-03-20 | 16:00 | Ponferradina | 1.3 | 2–2 | 1.2 | Eibar | 5,414 | Estadio El Toralín | Álvaro Moreno | Match Report | |
| 32 | Sun | 2022-03-20 | 18:15 | Leganés | 0.7 | 1–1 | 0.6 | Sporting Gijón | 8,189 | Estadio Municipal de Butarque | Iván Caparrós | Match Report | |
| 32 | Mon | 2022-03-21 | 20:00 | Tenerife | 0.9 | 0–1 | 1.0 | Almería | 15,007 | Estadio Heliodoro Rodríguez Lopéz | Oliver De La Fuente | Match Report | |
| 33 | Fri | 2022-03-25 | 21:00 | Zaragoza | 1.2 | 1–1 | 0.8 | Amorebieta | 15,556 | Estadio de la Romareda | Rubén Ávalos | Match Report | |
| 33 | Sat | 2022-03-26 | 14:00 | Ibiza | 1.4 | 2–2 | 1.9 | Real Sociedad B | 2,544 | Estadio Municipal de Can Misses | Dámaso Arcediano | Match Report | |
| 33 | Sat | 2022-03-26 | 16:00 | Eibar | 1.9 | 1–0 | 0.3 | Lugo | 5,103 | Estadio Municipal de Ipurúa | Víctor García Verdura | Match Report | |
| 33 | Sat | 2022-03-26 | 18:00 | Sporting Gijón | 2.0 | 4–1 | 0.9 | Cartagena | 14,182 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| 33 | Sat | 2022-03-26 | 21:30 | Oviedo | 2.9 | 3–0 | 1.1 | Fuenlabrada | 11,134 | Estadio Carlos Tartiere | Raúl González | Match Report | |
| 33 | Sun | 2022-03-27 | 14:00 | CD Mirandés | 3.5 | 3–1 | 0.7 | Ponferradina | 2,643 | Estadio Municipal de Anduva | Saúl Ais | Match Report | |
| 33 | Sun | 2022-03-27 | 16:00 | Burgos | 1.5 | 1–0 | 0.3 | Tenerife | 8,898 | Estadio Municipal de El Plantío | Eduardo Prieto | Match Report | |
| 33 | Sun | 2022-03-27 | 18:15 | Málaga | 0.9 | 0–2 | 1.7 | Huesca | 15,537 | Estadio La Rosaleda | Daniel Trujillo | Match Report | |
| 33 | Sun | 2022-03-27 | 18:15 | Alcorcón | 1.2 | 1–2 | 0.8 | Valladolid | 2,497 | Estadio Santo Domingo | Alejandro Quintero | Match Report | |
| 33 | Sun | 2022-03-27 | 21:00 | Almería | 2.3 | 0–1 | 1.6 | Girona | 9,260 | Estadio de los Juegos Mediterráneos | Gorka Sagues | Match Report | |
| 33 | Mon | 2022-03-28 | 20:00 | Las Palmas | 2.2 | 4–2 | 0.9 | Leganés | 6,961 | Estadio de Gran Canaria | Javier Villanueva | Match Report | |
| 34 | Fri | 2022-04-01 | 21:00 | Girona | 1.0 | 1–0 | 1.2 | Málaga | 5,863 | Estadi Municipal de Montilivi | Iván Caparrós | Match Report | |
| 34 | Sat | 2022-04-02 | 16:00 | Valladolid | 2.0 | 4–1 | 1.0 | Lugo | 13,516 | Estadio Municipal José Zorrilla | Jon González | Match Report | |
| 34 | Sat | 2022-04-02 | 16:00 | Real Sociedad B | 1.5 | 2–4 | 3.5 | Alcorcón | 6,866 | Estadio Municipal de Anoeta | Luis Milla | Match Report | |
| 34 | Sat | 2022-04-02 | 18:15 | Amorebieta | 2.0 | 3–1 | 0.5 | Ibiza | 902 | Instalaciones de Lezama Campo 2 | Francisco Hernández | Match Report | |
| 34 | Sat | 2022-04-02 | 19:30 | Tenerife | 0.5 | 1–1 | 2.3 | Zaragoza | 12,089 | Estadio Heliodoro Rodríguez Lopéz | David Gálvez | Match Report | |
| 34 | Sun | 2022-04-03 | 14:00 | Cartagena | 1.4 | 1–2 | 0.9 | Oviedo | 7,181 | Estadio Municipal Cartagonova | Álvaro Moreno | Match Report | |
| 34 | Sun | 2022-04-03 | 16:00 | Burgos | 0.7 | 0–0 | 0.6 | Sporting Gijón | 7,246 | Estadio Municipal de El Plantío | Rafael Sánchez | Match Report | |
| 34 | Sun | 2022-04-03 | 16:00 | Ponferradina | 0.7 | 1–2 | 2.4 | Las Palmas | 5,745 | Estadio El Toralín | Aitor Gorostegui | Match Report | |
| 34 | Sun | 2022-04-03 | 18:15 | Eibar | 1.3 | 1–1 | 1.0 | CD Mirandés | 5,480 | Estadio Municipal de Ipurúa | Iosu Galech | Match Report | |
| 34 | Sun | 2022-04-03 | 18:15 | Huesca | 1.6 | 1–1 | 0.5 | Almería | 5,832 | Estadio El Alcoraz | José López | Match Report | |
| 34 | Mon | 2022-04-04 | 21:00 | Leganés | 1.5 | 3–2 | 0.9 | Fuenlabrada | 6,898 | Estadio Municipal de Butarque | Oliver De La Fuente | Match Report | |
| 35 | Fri | 2022-04-08 | 21:00 | Lugo | 2.2 | 1–0 | 1.1 | Cartagena | 2,197 | Estadio Anxo Carro | Eduardo Prieto | Match Report | |
| 35 | Sat | 2022-04-09 | 16:00 | Real Sociedad B | 1.2 | 1–2 | 1.1 | Tenerife | 4,941 | Estadio Municipal de Anoeta | Rubén Ávalos | Match Report | |
| 35 | Sat | 2022-04-09 | 18:15 | Alcorcón | 0.9 | 1–1 | 1.1 | Sporting Gijón | 2,075 | Estadio Santo Domingo | Gorka Sagues | Match Report | |
| 35 | Sat | 2022-04-09 | 18:15 | Málaga | 2.1 | 2–2 | 2.5 | Valladolid | 18,004 | Estadio La Rosaleda | Juan Pulido | Match Report | |
| 35 | Sat | 2022-04-09 | 20:00 | Las Palmas | 1.0 | 1–0 | 1.1 | Amorebieta | 12,825 | Estadio de Gran Canaria | Víctor García Verdura | Match Report | |
| 35 | Sun | 2022-04-10 | 14:00 | Fuenlabrada | 0.9 | 2–3 | 0.9 | Huesca | 2,354 | Estadio Fernando Torres | Alejandro Quintero | Match Report | |
| 35 | Sun | 2022-04-10 | 16:00 | Zaragoza | 1.3 | 1–0 | 0.7 | Girona | 17,957 | Estadio de la Romareda | Javier Villanueva | Match Report | |
| 35 | Sun | 2022-04-10 | 18:15 | CD Mirandés | 2.1 | 3–1 | 0.2 | Burgos | 4,924 | Estadio Municipal de Anduva | Raúl González | Match Report | |
| 35 | Sun | 2022-04-10 | 18:15 | Oviedo | 0.4 | 1–0 | 0.5 | Leganés | 15,510 | Estadio Carlos Tartiere | Dámaso Arcediano | Match Report | |
| 35 | Sun | 2022-04-10 | 18:15 | Ibiza | 1.4 | 2–0 | 1.3 | Eibar | 5,012 | Estadio Municipal de Can Misses | Saúl Ais | Match Report | |
| 35 | Mon | 2022-04-11 | 21:00 | Almería | 1.4 | 3–0 | 0.3 | Ponferradina | 9,836 | Estadio de los Juegos Mediterráneos | Daniel Trujillo | Match Report | |
| 36 | Fri | 2022-04-15 | 18:30 | Eibar | 2.1 | 2–2 | 1.4 | Las Palmas | 4,110 | Estadio Municipal de Ipurúa | José López | Match Report | |
| 36 | Fri | 2022-04-15 | 21:00 | Amorebieta | 1.0 | 1–0 | 0.8 | CD Mirandés | 1,291 | Instalaciones de Lezama Campo 2 | David Gálvez | Match Report | |
| 36 | Sat | 2022-04-16 | 16:00 | Leganés | 0.6 | 0–3 | 1.8 | Málaga | 5,169 | Estadio Municipal de Butarque | Aitor Gorostegui | Match Report | |
| 36 | Sat | 2022-04-16 | 18:15 | Valladolid | 1.1 | 2–2 | 1.8 | Almería | 19,608 | Estadio Municipal José Zorrilla | Francisco Hernández | Match Report | |
| 36 | Sat | 2022-04-16 | 20:30 | Sporting Gijón | 1.9 | 0–1 | 0.6 | Oviedo | 23,470 | Estadio Municipal El Molinón | Daniel Trujillo | Match Report | |
| 36 | Sat | 2022-04-16 | 21:00 | Cartagena | 1.5 | 3–1 | 1.0 | Alcorcón | 6,801 | Estadio Municipal Cartagonova | Iosu Galech | Match Report | |
| 36 | Sun | 2022-04-17 | 14:00 | Ponferradina | 0.5 | 3–1 | 1.5 | Lugo | 4,974 | Estadio El Toralín | Rafael Sánchez | Match Report | |
| 36 | Sun | 2022-04-17 | 16:00 | Burgos | 1.5 | 2–1 | 1.5 | Ibiza | 8,624 | Estadio Municipal de El Plantío | Dámaso Arcediano | Match Report | |
| 36 | Sun | 2022-04-17 | 17:15 | Tenerife | 1.8 | 3–1 | 0.4 | Fuenlabrada | 11,783 | Estadio Heliodoro Rodríguez Lopéz | Iván Caparrós | Match Report | |
| 36 | Sun | 2022-04-17 | 18:15 | Huesca | 1.0 | 1–1 | 1.1 | Zaragoza | 8,143 | Estadio El Alcoraz | Jon González | Match Report | |
| 36 | Mon | 2022-04-18 | 19:00 | Girona | 2.1 | 2–0 | 0.5 | Real Sociedad B | 7,432 | Estadi Municipal de Montilivi | Oliver De La Fuente | Match Report | |
| 37 | Fri | 2022-04-22 | 20:00 | Tenerife | 1.1 | 0–0 | 0.4 | Huesca | 11,896 | Estadio Heliodoro Rodríguez Lopéz | Víctor García Verdura | Match Report | |
| 37 | Sat | 2022-04-23 | 14:00 | Real Sociedad B | 1.5 | 2–1 | 2.2 | Amorebieta | 3,038 | Estadio Municipal de Anoeta | Raúl González | Match Report | |
| 37 | Sat | 2022-04-23 | 16:15 | Fuenlabrada | 1.7 | 2–3 | 4.2 | Ponferradina | 2,119 | Estadio Fernando Torres | Rubén Ávalos | Match Report | |
| 37 | Sat | 2022-04-23 | 16:15 | Cartagena | 2.2 | 3–0 | 2.0 | Girona | 3,306 | Estadio Municipal Cartagonova | Luis Milla | Match Report | |
| 37 | Sat | 2022-04-23 | 18:30 | Málaga | 1.0 | 1–3 | 3.4 | Eibar | 17,667 | Estadio La Rosaleda | Javier Villanueva | Match Report | |
| 37 | Sun | 2022-04-24 | 14:00 | Alcorcón | 1.0 | 1–2 | 0.9 | Oviedo | 2,543 | Estadio Santo Domingo | Saúl Ais | Match Report | |
| 37 | Sun | 2022-04-24 | 16:15 | Ibiza | 1.4 | 1–1 | 1.2 | Las Palmas | 4,328 | Estadio Municipal de Can Misses | Gorka Sagues | Match Report | |
| 37 | Sun | 2022-04-24 | 16:15 | CD Mirandés | 1.5 | 0–1 | 0.7 | Valladolid | 41,040 | Estadio Municipal de Anduva | Álvaro Moreno | Match Report | |
| 37 | Sun | 2022-04-24 | 18:30 | Zaragoza | 0.6 | 0–0 | 0.4 | Burgos | 17,987 | Estadio de la Romareda | José López | Match Report | |
| 37 | Sun | 2022-04-24 | 18:30 | Lugo | 1.4 | 0–0 | 0.3 | Leganés | 2,261 | Estadio Anxo Carro | Alejandro Quintero | Match Report | |
| 37 | Mon | 2022-04-25 | 21:00 | Almería | 2.5 | 1–0 | 0.5 | Sporting Gijón | 9,897 | Estadio de los Juegos Mediterráneos | Jon González | Match Report | |
| 38 | Fri | 2022-04-29 | 21:00 | Las Palmas | 1.6 | 2–1 | 1.0 | Málaga | 10,644 | Estadio de Gran Canaria | Oliver De La Fuente | Match Report | |
| 38 | Sat | 2022-04-30 | 16:00 | Oviedo | 1.7 | 3–0 | 0.8 | CD Mirandés | 15,108 | Estadio Carlos Tartiere | Iván Caparrós | Match Report | |
| 38 | Sat | 2022-04-30 | 18:15 | Eibar | 1.8 | 2–0 | 0.2 | Zaragoza | 5,973 | Estadio Municipal de Ipurúa | Daniel Trujillo | Match Report | |
| 38 | Sat | 2022-04-30 | 20:30 | Burgos | 2.0 | 0–2 | 1.2 | Almería | 8,479 | Estadio Municipal de El Plantío | Juan Pulido | Match Report | |
| 38 | Sun | 2022-05-01 | 14:00 | Amorebieta | 2.1 | 2–1 | 1.2 | Fuenlabrada | 1,066 | Instalaciones de Lezama Campo 2 | Iosu Galech | Match Report | |
| 38 | Sun | 2022-05-01 | 16:00 | Alcorcón | 0.2 | 0–1 | 2.1 | Girona | 951 | Estadio Santo Domingo | Aitor Gorostegui | Match Report | |
| 38 | Sun | 2022-05-01 | 16:00 | Sporting Gijón | 1.2 | 0–1 | 0.6 | Ibiza | 11,740 | Estadio Municipal El Molinón | Eduardo Prieto | Match Report | |
| 38 | Sun | 2022-05-01 | 18:15 | Ponferradina | 3.1 | 4–2 | 2.3 | Cartagena | 5,658 | Estadio El Toralín | Dámaso Arcediano | Match Report | |
| 38 | Sun | 2022-05-01 | 18:15 | Lugo | 0.6 | 0–2 | 1.3 | Tenerife | 2,580 | Estadio Anxo Carro | Francisco Hernández | Match Report | |
| 38 | Mon | 2022-05-02 | 18:30 | Leganés | 1.3 | 2–1 | 1.2 | Huesca | 4,416 | Estadio Municipal de Butarque | Rafael Sánchez | Match Report | |
| 38 | Mon | 2022-05-02 | 21:00 | Valladolid | 1.4 | 1–2 | 0.9 | Real Sociedad B | 14,326 | Estadio Municipal José Zorrilla | David Gálvez | Match Report | |
| 39 | Fri | 2022-05-06 | 20:00 | Las Palmas | 1.4 | 1–0 | 1.1 | CD Mirandés | 11,299 | Estadio de Gran Canaria | Alejandro Quintero | Match Report | |
| 39 | Sat | 2022-05-07 | 16:00 | Fuenlabrada | 1.4 | 1–2 | 2.5 | Real Sociedad B | 1,230 | Estadio Fernando Torres | José López | Match Report | |
| 39 | Sat | 2022-05-07 | 16:00 | Huesca | 0.8 | 1–1 | 1.3 | Sporting Gijón | 4,740 | Estadio El Alcoraz | Raúl González | Match Report | |
| 39 | Sat | 2022-05-07 | 18:15 | Almería | 3.0 | 3–0 | 0.5 | Amorebieta | 13,478 | Estadio de los Juegos Mediterráneos | Javier Villanueva | Match Report | |
| 39 | Sat | 2022-05-07 | 18:15 | Málaga | 0.3 | 0–0 | 0.6 | Oviedo | 21,384 | Estadio La Rosaleda | Rubén Ávalos | Match Report | |
| 39 | Sat | 2022-05-07 | 21:00 | Ponferradina | 2.0 | 3–1 | 1.8 | Burgos | 5,651 | Estadio El Toralín | Iosu Galech | Match Report | |
| 39 | Sun | 2022-05-08 | 14:00 | Cartagena | 0.6 | 0–0 | 0.9 | Leganés | 4,560 | Estadio Municipal Cartagonova | Saúl Ais | Match Report | |
| 39 | Sun | 2022-05-08 | 16:00 | Eibar | 0.5 | 0–2 | 1.6 | Valladolid | 7,237 | Estadio Municipal de Ipurúa | Luis Milla | Match Report | |
| 39 | Sun | 2022-05-08 | 18:15 | Zaragoza | 1.9 | 0–3 | 1.3 | Alcorcón | 13,125 | Estadio de la Romareda | Gorka Sagues | Match Report | |
| 39 | Sun | 2022-05-08 | 18:15 | Ibiza | 1.3 | 1–1 | 0.4 | Lugo | 3,262 | Estadio Municipal de Can Misses | Víctor García Verdura | Match Report | |
| 39 | Mon | 2022-05-09 | 21:00 | Girona | 1.6 | 0–1 | 0.9 | Tenerife | 6,587 | Estadi Municipal de Montilivi | Jon González | Match Report | |
| 40 | Fri | 2022-05-13 | 21:00 | Real Sociedad B | 0.7 | 0–2 | 1.9 | Almería | 8,140 | Estadio Municipal de Anoeta | Iván Caparrós | Match Report | |
| 40 | Sat | 2022-05-14 | 14:00 | Amorebieta | 1.2 | 1–0 | 0.5 | Huesca | 1,007 | Instalaciones de Lezama Campo 2 | Dámaso Arcediano | Match Report | |
| 40 | Sat | 2022-05-14 | 16:00 | Lugo | 1.5 | 1–3 | 3.1 | Fuenlabrada | 1,639 | Estadio Anxo Carro | Aitor Gorostegui | Match Report | |
| 40 | Sat | 2022-05-14 | 16:00 | Burgos | 1.3 | 1–1 | 1.0 | Cartagena | 7,296 | Estadio Municipal de El Plantío | David Gálvez | Match Report | |
| 40 | Sat | 2022-05-14 | 18:15 | Valladolid | 1.0 | 2–0 | 0.6 | Ponferradina | 20,213 | Estadio Municipal José Zorrilla | Daniel Trujillo | Match Report | |
| 40 | Sat | 2022-05-14 | 21:00 | Leganés | 1.9 | 2–3 | 1.0 | Eibar | 5,752 | Estadio Municipal de Butarque | Francisco Hernández | Match Report | |
| 40 | Sun | 2022-05-15 | 14:00 | Alcorcón | 1.1 | 0–2 | 1.0 | Las Palmas | 1,557 | Estadio Santo Domingo | Iosu Galech | Match Report | |
| 40 | Sun | 2022-05-15 | 16:00 | Sporting Gijón | 1.1 | 2–1 | 0.6 | Girona | 20,140 | Estadio Municipal El Molinón | Juan Pulido | Match Report | |
| 40 | Sun | 2022-05-15 | 16:00 | CD Mirandés | 2.3 | 4–0 | 1.6 | Ibiza | 2,568 | Estadio Municipal de Anduva | Rafael Sánchez | Match Report | |
| 40 | Sun | 2022-05-15 | 20:00 | Tenerife | 1.4 | 0–2 | 0.8 | Málaga | 14,672 | Estadio Heliodoro Rodríguez Lopéz | Eduardo Prieto | Match Report | |
| 40 | Mon | 2022-05-16 | 21:00 | Oviedo | 2.9 | 3–3 | 1.4 | Zaragoza | 13,529 | Estadio Carlos Tartiere | Oliver De La Fuente | Match Report | |
| 41 | Fri | 2022-05-20 | 21:00 | Zaragoza | 1.2 | 1–0 | 1.7 | Lugo | 10,256 | Estadio de la Romareda | Álvaro Moreno | Match Report | |
| 41 | Sat | 2022-05-21 | 20:00 | Cartagena | 3.4 | 5–0 | 1.3 | Amorebieta | 4,244 | Estadio Municipal Cartagonova | Víctor García Verdura | Match Report | |
| 41 | Sat | 2022-05-21 | 20:00 | Málaga | 1.2 | 0–1 | 1.0 | Burgos | 25,389 | Estadio La Rosaleda | Jon González | Match Report | |
| 41 | Sat | 2022-05-21 | 20:00 | Huesca | 1.1 | 3–2 | 3.0 | Real Sociedad B | 3,811 | Estadio El Alcoraz | Alejandro Quintero | Match Report | |
| 41 | Sat | 2022-05-21 | 20:00 | Fuenlabrada | 1.1 | 0–0 | 0.6 | Sporting Gijón | 2,439 | Estadio Fernando Torres | Javier Villanueva | Match Report | |
| 41 | Sat | 2022-05-21 | 21:00 | Las Palmas | 0.6 | 2–1 | 0.7 | Oviedo | 30,063 | Estadio de Gran Canaria | Saúl Ais | Match Report | |
| 41 | Sat | 2022-05-21 | 22:00 | Ponferradina | 2.4 | 0–3 | 2.2 | Leganés | 7,361 | Estadio El Toralín | Luis Milla | Match Report | |
| 41 | Sat | 2022-05-21 | 22:00 | Girona | 2.4 | 2–0 | 0.3 | CD Mirandés | 6,925 | Estadi Municipal de Montilivi | Gorka Sagues | Match Report | |
| 41 | Sat | 2022-05-21 | 22:00 | Almería | 1.8 | 1–1 | 1.0 | Alcorcón | 14,759 | Estadio de los Juegos Mediterráneos | Raúl González | Match Report | |
| 41 | Sat | 2022-05-21 | 22:00 | Eibar | 3.2 | 2–0 | 0.3 | Tenerife | 7,135 | Estadio Municipal de Ipurúa | Rubén Ávalos | Match Report | |
| 41 | Sat | 2022-05-21 | 22:00 | Ibiza | 2.1 | 1–2 | 2.9 | Valladolid | 4,614 | Estadio Municipal de Can Misses | José López | Match Report | |
| 42 | Fri | 2022-05-27 | 21:00 | Real Sociedad B | 0.6 | 1–2 | 2.5 | Zaragoza | 2,622 | Estadio Municipal de Anoeta | Rafael Sánchez | Match Report | |
| 42 | Fri | 2022-05-27 | 21:00 | CD Mirandés | 2.6 | 5–1 | 1.6 | Fuenlabrada | 2,363 | Estadio Municipal de Anduva | Luis Milla | Match Report | |
| 42 | Sat | 2022-05-28 | 18:15 | Amorebieta | 1.4 | 1–0 | 1.9 | Ponferradina | 1,218 | Instalaciones de Lezama Campo 2 | David Gálvez | Match Report | |
| 42 | Sat | 2022-05-28 | 18:15 | Lugo | 1.5 | 1–0 | 0.5 | Málaga | 3,741 | Estadio Anxo Carro | Oliver De La Fuente | Match Report | |
| 42 | Sun | 2022-05-29 | 19:00 | Tenerife | 2.1 | 1–2 | 1.5 | Cartagena | 14,567 | Estadio Heliodoro Rodríguez Lopéz | Iosu Galech | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Sporting Gijón | 0.3 | 0–1 | 1.4 | Las Palmas | 12,346 | Estadio Municipal El Molinón | Eduardo Prieto | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Oviedo | 2.2 | 3–2 | 1.7 | Ibiza | 21,729 | Estadio Carlos Tartiere | Gorka Sagues | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Leganés | 1.8 | 2–2 | 1.5 | Almería | 8,654 | Estadio Municipal de Butarque | Dámaso Arcediano | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Valladolid | 2.2 | 3–0 | 0.4 | Huesca | 22,397 | Estadio Municipal José Zorrilla | Juan Pulido | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Alcorcón | 0.7 | 1–0 | 1.8 | Eibar | 2,319 | Estadio Santo Domingo | Iván Caparrós | Match Report | |
| 42 | Sun | 2022-05-29 | 20:00 | Burgos | 1.0 | 0–0 | 0.3 | Girona | 11,152 | Estadio Municipal de El Plantío | Daniel Trujillo | Match Report |
| Round | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Semi-finals | Wed | 2022-06-01 | 20:00 | Tenerife | 1.5 | 1–0 | 0.8 | Las Palmas | 19,732 | Estadio Heliodoro Rodríguez Lopéz | Javier Villanueva | Match Report | Leg 1 of 2 |
| Semi-finals | Thu | 2022-06-02 | 19:00 | Girona | 0.8 | 0–1 | 0.5 | Eibar | 9,450 | Estadi Municipal de Montilivi | Luis Milla | Match Report | Leg 1 of 2 |
| Semi-finals | Sat | 2022-06-04 | 20:00 | Las Palmas | 0.7 | 1–2 | 1.5 | Tenerife | 31,502 | Estadio de Gran Canaria | Jon González | Match Report | Leg 2 of 2; Tenerife won |
| Semi-finals | Sun | 2022-06-05 | 18:30 | Eibar | 1.2 | 0–2 | 0.9 | Girona | 6,846 | Estadio Municipal de Ipurúa | Juan Pulido | Match Report | Leg 2 of 2; Girona won |
| Final | Sat | 2022-06-11 | 21:00 | Girona | 0.9 | 0–0 | 0.2 | Tenerife | 11,303 | Estadi Municipal de Montilivi | Francisco Hernández | Match Report | Leg 1 of 2 |
| Final | Sun | 2022-06-19 | 20:00 | Tenerife | 0.7 | 1–3 | 1.6 | Girona | 22,077 | Estadio Heliodoro Rodríguez Lopéz | Dámaso Arcediano | Match Report | Leg 2 of 2; Girona won |
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