Qualifying stages

Third qualifying stage (March 8, 2022 to March 17, 2022)

Club Crest The Strongest
2–1
Univ Católica Club Crest
Mar 10
Univ Católica
0–0
The Strongest
Mar 17
The Strongest
2–1
Univ Católica
The Strongest won on aggregate score over two legs and advance to Group stage.
Club Crest Estudiantes
2–0
Everton Club Crest
Mar 9
Everton
0–1
Estudiantes
Mar 16
Estudiantes
1–0
Everton
Estudiantes won on aggregate score over two legs and advance to Group stage.
Club Crest Olimpia
3–3
Fluminense Club Crest
Mar 9
Fluminense
3–1
Olimpia
Mar 16
Olimpia
2–0
Fluminense
Olimpia won on penalty kicks following extra time and advance to Group stage.
Club Crest América (MG)
0–0
Barcelona Club Crest
Mar 8
América (MG)
0–0
Barcelona
Mar 15
Barcelona
0–0
América (MG)
América (MG) won on penalty kicks following extra time and advance to Group stage.

Second qualifying stage (February 22, 2022 to March 3, 2022)

Club Crest Estudiantes
2–1
Audax Italiano Club Crest
Feb 23
Audax Italiano
1–0
Estudiantes
Mar 2
Estudiantes
2–0
Audax Italiano
Estudiantes won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest Fluminense
4–1
Millonarios Club Crest
Feb 22
Millonarios
1–2
Fluminense
Mar 1
Fluminense
2–0
Millonarios
Fluminense won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest América (MG)
3–3
Guaraní Club Crest
Feb 23
América (MG)
0–1
Guaraní
Mar 2
Guaraní
2–3
América (MG)
América (MG) won on penalty kicks following extra time and advance to Third qualifying stage.
Club Crest Everton
3–1
Monagas Club Crest
Feb 22
Everton
3–0
Monagas
Mar 1
Monagas
1–0
Everton
Everton won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest Olimpia
4–2
Nacional Club Crest
Feb 24
Olimpia
3–1
Nacional
Mar 3
Nacional
1–1
Olimpia
Olimpia won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest Barcelona
3–0
Universitario Club Crest
Feb 23
Barcelona
2–0
Universitario
Mar 2
Universitario
0–1
Barcelona
Barcelona won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest The Strongest
3–2
Plaza Colonia Club Crest
Feb 22
Plaza Colonia
2–0
The Strongest
Mar 1
The Strongest
3–0
Plaza Colonia
The Strongest won on aggregate score over two legs and advance to Third qualifying stage.
Club Crest Univ Católica
3–1
Bolívar Club Crest
Feb 23
Bolívar
1–1
Univ Católica
Mar 2
Univ Católica
2–0
Bolívar
Univ Católica won on aggregate score over two legs and advance to Third qualifying stage.

First qualifying stage (February 8, 2022 to February 16, 2022)

Club Crest Barcelona
1–1
Torque Club Crest
Feb 8
Torque
1–1
Barcelona
Feb 15
Barcelona
0–0
Torque
Barcelona won on penalty kicks following extra time and advance to Second qualifying stage.
Club Crest Bolívar
7–2
Deportivo Lara Club Crest
Feb 9
Deportivo Lara
2–3
Bolívar
Feb 16
Bolívar
4–0
Deportivo Lara
Bolívar won on aggregate score over two legs and advance to Second qualifying stage.
Club Crest Olimpia
3–0
U César Vallejo Club Crest
Feb 9
U César Vallejo
0–1
Olimpia
Feb 16
Olimpia
2–0
U César Vallejo
Olimpia won on aggregate score over two legs and advance to Second qualifying stage.

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