Scores & Fixtures 2021-2022 Ligue 1
| Round | Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligue 1 | 1 | Fri | 2021-08-06 | 21:00 | Monaco | 1.5 | 1–1 | 0.2 | Nantes | 7,500 | Stade Louis II | Antony Gautier | Match Report | |
| Ligue 1 | 1 | Sat | 2021-08-07 | 17:00 | Lyon | 1.4 | 1–1 | 0.8 | Brest | 29,018 | Groupama Stadium | Mikael Lesage | Match Report | |
| Ligue 1 | 1 | Sat | 2021-08-07 | 21:00 | Troyes | 0.9 | 1–2 | 1.2 | Paris S-G | 15,248 | Stade de l'Aube | Amaury Delerue | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 13:00 | Rennes | 0.7 | 1–1 | 2.1 | Lens | 22,567 | Roazhon Park | Bastien Dechepy | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 15:00 | Bordeaux | 0.7 | 0–2 | 3.1 | Clermont Foot | 18,748 | Stade Matmut-Atlantique | Florent Batta | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 15:00 | Strasbourg | 0.3 | 0–2 | 0.9 | Angers | 23,250 | Stade de la Meinau | Jeremy Stinat | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 15:00 | Nice | 0.8 | 0–0 | 0.2 | Reims | 18,030 | Stade de Nice | Johan Hamel | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 15:00 | Saint-Étienne | 1.9 | 1–1 | 0.6 | Lorient | 20,461 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 17:00 | Metz | 0.9 | 3–3 | 1.3 | Lille | 15,551 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| Ligue 1 | 1 | Sun | 2021-08-08 | 20:45 | Montpellier | 0.6 | 2–3 | 1.9 | Marseille | 13,500 | Stade de la Mosson | Jérémie Pignard | Match Report | |
| Ligue 1 | 2 | Fri | 2021-08-13 | 21:00 | Lorient | 0.8 | 1–0 | 1.1 | Monaco | 12,149 | Stade du Moustoir | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 2 | Sat | 2021-08-14 | 17:00 | Lille | 0.8 | 0–4 | 1.9 | Nice | 30,144 | Stade Pierre-Mauroy | Jérôme Brisard | Match Report | |
| Ligue 1 | 2 | Sat | 2021-08-14 | 21:00 | Paris S-G | 3.1 | 4–2 | 0.7 | Strasbourg | 46,962 | Parc des Princes | Willy Delajod | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 13:00 | Angers | 1.8 | 3–0 | 0.9 | Lyon | 6,154 | Stade Raymond Kopa | Clément Turpin | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 15:00 | Clermont Foot | 1.9 | 2–0 | 0.7 | Troyes | 11,005 | Stade Gabriel Montpied | Romain Lissorgue | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 15:00 | Brest | 1.9 | 1–1 | 1.0 | Rennes | 14,271 | Stade Francis-Le Blé | Benoît Bastien | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 15:00 | Nantes | 1.7 | 2–0 | 0.6 | Metz | 12,054 | Stade de la Beaujoire - Louis Fonteneau | Johan Hamel | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 15:00 | Reims | 1.8 | 3–3 | 1.8 | Montpellier | 8,887 | Stade Auguste-Delaune | Jeremy Stinat | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 17:00 | Lens | 1.3 | 2–2 | 0.9 | Saint-Étienne | 35,541 | Stade Bollaert-Delelis | Amaury Delerue | Match Report | |
| Ligue 1 | 2 | Sun | 2021-08-15 | 20:45 | Marseille | 1.0 | 2–2 | 0.3 | Bordeaux | 50,000 | Orange Vélodrome | Ruddy Buquet | Match Report | |
| Ligue 1 | 3 | Fri | 2021-08-20 | 21:00 | Brest | 1.1 | 2–4 | 0.9 | Paris S-G | 14,586 | Stade Francis-Le Blé | Eric Wattellier | Match Report | |
| Ligue 1 | 3 | Sat | 2021-08-21 | 17:00 | Monaco | 0.3 | 0–2 | 0.5 | Lens | 6,483 | Stade Louis II | Jérémie Pignard | Match Report | |
| Ligue 1 | 3 | Sat | 2021-08-21 | 21:00 | Saint-Étienne | 0.5 | 1–1 | 1.0 | Lille | 20,673 | Stade Geoffroy-Guichard | Mikael Lesage | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 13:00 | Lyon | 3.3 | 3–3 | 1.4 | Clermont Foot | 34,713 | Groupama Stadium | Thomas Léonard | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 15:00 | Strasbourg | 2.2 | 1–1 | 1.4 | Troyes | 22,185 | Stade de la Meinau | Jérôme Brisard | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 15:00 | Metz | 0.5 | 1–1 | 0.9 | Reims | 14,799 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 15:00 | Montpellier | 3.0 | 3–1 | 0.6 | Lorient | 6,527 | Stade de la Mosson | Bastien Dechepy | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 15:00 | Bordeaux | 0.5 | 1–1 | 0.9 | Angers | 18,281 | Stade Matmut-Atlantique | Pierre Gaillouste | Match Report | |
| Ligue 1 | 3 | Sun | 2021-08-22 | 17:00 | Rennes | 0.9 | 1–0 | 0.5 | Nantes | 27,569 | Roazhon Park | Stéphanie Frappart | Match Report | |
| Ligue 1 | 4 | Fri | 2021-08-27 | 21:00 | Nantes | 1.4 | 0–1 | 1.2 | Lyon | 23,177 | Stade de la Beaujoire - Louis Fonteneau | Jérôme Brisard | Match Report | |
| Ligue 1 | 4 | Sat | 2021-08-28 | 17:00 | Nice | 3.2 | 4–0 | 1.1 | Bordeaux | Stade de Nice | Jérémie Pignard | Match Report | ||
| Ligue 1 | 4 | Sat | 2021-08-28 | 21:00 | Marseille | 2.1 | 3–1 | 1.1 | Saint-Étienne | 55,039 | Orange Vélodrome | Benoît Millot | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 13:00 | Troyes | 0.7 | 1–2 | 1.9 | Monaco | 9,866 | Stade de l'Aube | Johan Hamel | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 15:00 | Strasbourg | 1.4 | 3–1 | 0.8 | Brest | 22,341 | Stade de la Meinau | Romain Lissorgue | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 15:00 | Angers | 2.2 | 2–0 | 0.9 | Rennes | 6,473 | Stade Raymond Kopa | Antony Gautier | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 15:00 | Lens | 1.3 | 2–2 | 1.2 | Lorient | 35,029 | Stade Bollaert-Delelis | Willy Delajod | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 15:00 | Clermont Foot | 1.6 | 2–2 | 1.4 | Metz | 11,274 | Stade Gabriel Montpied | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 17:00 | Lille | 1.6 | 2–1 | 0.6 | Montpellier | 28,859 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| Ligue 1 | 4 | Sun | 2021-08-29 | 20:45 | Reims | 0.7 | 0–2 | 1.3 | Paris S-G | 20,525 | Stade Auguste-Delaune | François Letexier | Match Report | |
| Ligue 1 | 5 | Fri | 2021-09-10 | 21:00 | Lorient | 1.8 | 2–1 | 1.3 | Lille | 10,271 | Stade du Moustoir | Clément Turpin | Match Report | |
| Ligue 1 | 5 | Sat | 2021-09-11 | 17:00 | Paris S-G | 2.5 | 4–0 | 0.9 | Clermont Foot | 47,329 | Parc des Princes | Mikael Lesage | Match Report | |
| Ligue 1 | 5 | Sat | 2021-09-11 | 21:00 | Monaco | 0.8 | 0–2 | 1.6 | Marseille | 8,615 | Stade Louis II | Stéphanie Frappart | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 13:00 | Montpellier | 1.1 | 2–0 | 0.8 | Saint-Étienne | 10,402 | Stade de la Mosson | Benoît Bastien | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 15:00 | Rennes | 0.6 | 0–2 | 0.5 | Reims | 24,486 | Roazhon Park | Thomas Léonard | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 15:00 | Bordeaux | 0.8 | 2–3 | 2.5 | Lens | 19,763 | Stade Matmut-Atlantique | Luís Godinho | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 15:00 | Brest | 1.3 | 1–1 | 1.2 | Angers | 10,982 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 15:00 | Metz | 0.7 | 0–2 | 0.6 | Troyes | 15,269 | Stade Saint-Symphorien | Pierre Gaillouste | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 17:00 | Nantes | 1.7 | 0–2 | 2.1 | Nice | 14,597 | Stade de la Beaujoire - Louis Fonteneau | Benoît Millot | Match Report | |
| Ligue 1 | 5 | Sun | 2021-09-12 | 20:45 | Lyon | 1.6 | 3–1 | 1.6 | Strasbourg | 33,267 | Groupama Stadium | Ruddy Buquet | Match Report | |
| Ligue 1 | 6 | Fri | 2021-09-17 | 21:00 | Strasbourg | 2.0 | 3–0 | 0.6 | Metz | 25,437 | Stade de la Meinau | Eric Wattellier | Match Report | |
| Ligue 1 | 6 | Sat | 2021-09-18 | 17:00 | Lens | 0.6 | 1–0 | 0.7 | Lille | 36,512 | Stade Bollaert-Delelis | Benoît Millot | Match Report | |
| Ligue 1 | 6 | Sat | 2021-09-18 | 21:00 | Saint-Étienne | 1.4 | 1–2 | 2.3 | Bordeaux | 23,869 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 13:00 | Nice | 1.7 | 2–2 | 2.4 | Monaco | Stade de Nice | François Letexier | Match Report | ||
| Ligue 1 | 6 | Sun | 2021-09-19 | 15:00 | Troyes | 1.1 | 1–1 | 0.2 | Montpellier | 7,405 | Stade de l'Aube | Florent Batta | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 15:00 | Clermont Foot | 1.1 | 1–1 | 0.5 | Brest | 11,224 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 15:00 | Reims | 0.8 | 0–0 | 0.3 | Lorient | 9,443 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 15:00 | Angers | 0.9 | 1–4 | 2.1 | Nantes | 9,046 | Stade Raymond Kopa | Amaury Delerue | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 17:00 | Marseille | 2.1 | 2–0 | 1.5 | Rennes | 54,188 | Orange Vélodrome | Willy Delajod | Match Report | |
| Ligue 1 | 6 | Sun | 2021-09-19 | 20:45 | Paris S-G | 2.0 | 2–1 | 0.8 | Lyon | 47,611 | Parc des Princes | Clément Turpin | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 19:00 | Rennes | 2.4 | 6–0 | 0.3 | Clermont Foot | 24,109 | Roazhon Park | Benoît Bastien | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 19:00 | Nantes | 1.3 | 3–1 | 0.8 | Brest | 19,676 | Stade de la Beaujoire - Louis Fonteneau | Thomas Léonard | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 19:00 | Lille | 0.7 | 2–1 | 1.3 | Reims | 32,604 | Stade Pierre-Mauroy | Johan Hamel | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 19:00 | Montpellier | 1.3 | 3–3 | 1.2 | Bordeaux | 9,585 | Stade de la Mosson | Mikael Lesage | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 19:00 | Monaco | 1.7 | 3–1 | 0.4 | Saint-Étienne | 3,579 | Stade Louis II | Jérôme Brisard | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 21:00 | Lyon | 1.8 | 3–1 | 1.4 | Troyes | 29,714 | Groupama Stadium | Stéphanie Frappart | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 21:00 | Lens | 1.5 | 0–1 | 1.1 | Strasbourg | Stade Bollaert-Delelis | Jeremy Stinat | Match Report | ||
| Ligue 1 | 7 | Wed | 2021-09-22 | 21:00 | Lorient | 0.5 | 1–0 | 2.2 | Nice | 10,687 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 21:00 | Angers | 0.4 | 0–0 | 0.7 | Marseille | 12,458 | Stade Raymond Kopa | Ruddy Buquet | Match Report | |
| Ligue 1 | 7 | Wed | 2021-09-22 | 21:00 | Metz | 0.9 | 1–2 | 1.3 | Paris S-G | 2,661 | Stade Saint-Symphorien | Jérémie Pignard | Match Report | |
| Ligue 1 | 8 | Sat | 2021-09-25 | 17:00 | Saint-Étienne | 0.6 | 0–3 | 2.2 | Nice | 19,980 | Stade Geoffroy-Guichard | Amaury Delerue | Match Report | |
| Ligue 1 | 8 | Sat | 2021-09-25 | 19:00 | Strasbourg | 0.4 | 1–2 | 2.3 | Lille | 23,762 | Stade de la Meinau | François Letexier | Match Report | |
| Ligue 1 | 8 | Sat | 2021-09-25 | 21:00 | Paris S-G | 2.1 | 2–0 | 0.2 | Montpellier | 47,408 | Parc des Princes | Antony Gautier | Match Report | |
| Ligue 1 | 8 | Sat | 2021-09-25 | 21:00 | Lyon | 1.3 | 1–1 | 0.7 | Lorient | 36,424 | Groupama Stadium | Bastien Dechepy | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 13:00 | Bordeaux | 0.7 | 1–1 | 2.0 | Rennes | 16,675 | Stade Matmut-Atlantique | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 15:00 | Troyes | 1.0 | 1–1 | 1.3 | Angers | 6,868 | Stade de l'Aube | Thomas Léonard | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 15:00 | Brest | 1.6 | 1–2 | 0.6 | Metz | 10,398 | Stade Francis-Le Blé | Willy Delajod | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 15:00 | Reims | 1.1 | 3–1 | 0.6 | Nantes | 280 | Stade Auguste-Delaune | Eric Wattellier | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 17:00 | Clermont Foot | 1.1 | 1–3 | 1.6 | Monaco | 11,529 | Stade Gabriel Montpied | Benoît Millot | Match Report | |
| Ligue 1 | 8 | Sun | 2021-09-26 | 20:45 | Marseille | 2.0 | 2–3 | 2.0 | Lens | 50,001 | Orange Vélodrome | Mikael Lesage | Match Report | |
| Ligue 1 | 9 | Fri | 2021-10-01 | 21:00 | Lens | 2.1 | 2–0 | 0.1 | Reims | Stade Bollaert-Delelis | Benoît Bastien | Match Report | ||
| Ligue 1 | 9 | Sat | 2021-10-02 | 17:00 | Montpellier | 1.1 | 1–1 | 0.3 | Strasbourg | 9,851 | Stade de la Mosson | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 9 | Sat | 2021-10-02 | 21:00 | Nice | 3.8 | 2–1 | 0.6 | Brest | 13,503 | Stade de Nice | António Nobre | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 13:00 | Rennes | 1.0 | 2–0 | 1.5 | Paris S-G | 28,092 | Roazhon Park | Ruddy Buquet | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 15:00 | Lorient | 0.5 | 1–1 | 1.1 | Clermont Foot | 12,611 | Stade du Moustoir | Pierre Gaillouste | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 15:00 | Monaco | 1.6 | 3–0 | 0.3 | Bordeaux | 3,667 | Stade Louis II | Clément Turpin | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 15:00 | Angers | 2.3 | 3–2 | 1.1 | Metz | 3,989 | Stade Raymond Kopa | Stéphanie Frappart | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 15:00 | Nantes | 1.9 | 2–0 | 1.3 | Troyes | 15,150 | Stade de la Beaujoire - Louis Fonteneau | Jérôme Brisard | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 17:00 | Lille | 3.0 | 2–0 | 0.4 | Marseille | 44,839 | Stade Pierre-Mauroy | Jérémie Pignard | Match Report | |
| Ligue 1 | 9 | Sun | 2021-10-03 | 20:45 | Saint-Étienne | 2.3 | 1–1 | 1.3 | Lyon | 33,643 | Stade Geoffroy-Guichard | François Letexier | Match Report | |
| Ligue 1 | 10 | Fri | 2021-10-15 | 21:00 | Paris S-G | 2.0 | 2–1 | 1.1 | Angers | 47,646 | Parc des Princes | Bastien Dechepy | Match Report | |
| Ligue 1 | 10 | Sat | 2021-10-16 | 17:00 | Clermont Foot | 0.3 | 1–0 | 0.9 | Lille | 11,537 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| Ligue 1 | 10 | Sat | 2021-10-16 | 21:00 | Lyon | 2.6 | 2–0 | 0.6 | Monaco | 50,585 | Groupama Stadium | Amaury Delerue | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 13:00 | Troyes | 0.9 | 1–0 | 0.6 | Nice | 7,925 | Stade de l'Aube | Johan Hamel | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 15:00 | Brest | 0.5 | 1–1 | 0.8 | Reims | 9,693 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 15:00 | Bordeaux | 0.5 | 1–1 | 1.3 | Nantes | 39,510 | Stade Matmut-Atlantique | Willy Delajod | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 15:00 | Metz | 0.9 | 0–3 | 2.2 | Rennes | 15,679 | Stade Saint-Symphorien | Benoît Millot | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 15:00 | Strasbourg | 2.1 | 5–1 | 1.0 | Saint-Étienne | 25,371 | Stade de la Meinau | Mikael Lesage | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 17:00 | Montpellier | 1.5 | 1–0 | 0.9 | Lens | 12,474 | Stade de la Mosson | Florent Batta | Match Report | |
| Ligue 1 | 10 | Sun | 2021-10-17 | 20:45 | Marseille | 1.8 | 4–1 | 2.2 | Lorient | 57,349 | Orange Vélodrome | Antony Gautier | Match Report | |
| Ligue 1 | 11 | Fri | 2021-10-22 | 21:00 | Saint-Étienne | 1.6 | 2–2 | 0.5 | Angers | 19,836 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| Ligue 1 | 11 | Sat | 2021-10-23 | 17:00 | Nantes | 1.3 | 2–1 | 1.1 | Clermont Foot | 19,968 | Stade de la Beaujoire - Louis Fonteneau | Romain Lissorgue | Match Report | |
| Ligue 1 | 11 | Sat | 2021-10-23 | 21:00 | Lille | 1.7 | 1–1 | 1.2 | Brest | 32,613 | Stade Pierre-Mauroy | Clément Turpin | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 13:00 | Nice | 2.4 | 3–2 | 1.4 | Lyon | 24,519 | Stade de Nice | Jérôme Brisard | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 15:00 | Rennes | 1.2 | 1–0 | 0.9 | Strasbourg | 27,185 | Roazhon Park | Stéphanie Frappart | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 15:00 | Lens | 1.8 | 4–1 | 0.8 | Metz | 35,673 | Stade Bollaert-Delelis | Jérémie Pignard | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 15:00 | Lorient | 1.2 | 1–1 | 1.0 | Bordeaux | 11,678 | Stade du Moustoir | Thomas Léonard | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 15:00 | Reims | 0.8 | 1–2 | 0.9 | Troyes | 12,326 | Stade Auguste-Delaune | Pierre Gaillouste | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 17:00 | Monaco | 1.3 | 3–1 | 1.3 | Montpellier | 4,861 | Stade Louis II | François Letexier | Match Report | |
| Ligue 1 | 11 | Sun | 2021-10-24 | 20:45 | Marseille | 1.1 | 0–0 | 1.4 | Paris S-G | 65,121 | Orange Vélodrome | Benoît Bastien | Match Report | |
| Ligue 1 | 3 | Wed | 2021-10-27 | 21:00 | Nice | 1.5 | 1–1 | 0.5 | Marseille | Stade de l'Aube (Neutral Site) | Clément Turpin | Match Report | ||
| Ligue 1 | 12 | Fri | 2021-10-29 | 21:00 | Paris S-G | 2.1 | 2–1 | 1.8 | Lille | 47,874 | Parc des Princes | Amaury Delerue | Match Report | |
| Ligue 1 | 12 | Sat | 2021-10-30 | 17:00 | Metz | 0.4 | 1–1 | 0.4 | Saint-Étienne | 15,914 | Stade Saint-Symphorien | Stéphanie Frappart | Match Report | |
| Ligue 1 | 12 | Sat | 2021-10-30 | 21:00 | Lyon | 1.9 | 2–1 | 2.1 | Lens | 50,373 | Groupama Stadium | Mikael Lesage | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 13:00 | Angers | 1.2 | 1–2 | 0.8 | Nice | 6,788 | Stade Raymond Kopa | Willy Delajod | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 15:00 | Bordeaux | 1.8 | 3–2 | 1.4 | Reims | 11,020 | Stade Matmut-Atlantique | Eric Wattellier | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 15:00 | Troyes | 1.3 | 2–2 | 1.3 | Rennes | 8,550 | Stade de l'Aube | Jeremy Stinat | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 15:00 | Montpellier | 1.2 | 2–0 | 1.0 | Nantes | 11,267 | Stade de la Mosson | Bastien Dechepy | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 15:00 | Strasbourg | 2.3 | 4–0 | 1.3 | Lorient | 24,002 | Stade de la Meinau | Florent Batta | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 17:00 | Brest | 1.3 | 2–0 | 0.4 | Monaco | 12,463 | Stade Francis-Le Blé | Johan Hamel | Match Report | |
| Ligue 1 | 12 | Sun | 2021-10-31 | 20:45 | Clermont Foot | 0.7 | 0–1 | 1.0 | Marseille | 12,240 | Stade Gabriel Montpied | Benoît Millot | Match Report | |
| Ligue 1 | 13 | Fri | 2021-11-05 | 21:00 | Lens | 3.0 | 4–0 | 0.5 | Troyes | 35,706 | Stade Bollaert-Delelis | Thomas Léonard | Match Report | |
| Ligue 1 | 13 | Sat | 2021-11-06 | 17:00 | Lille | 1.4 | 1–1 | 1.1 | Angers | 33,305 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| Ligue 1 | 13 | Sat | 2021-11-06 | 21:00 | Bordeaux | 1.4 | 2–3 | 1.5 | Paris S-G | 41,172 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 13:00 | Marseille | 1.3 | 0–0 | 1.2 | Metz | 61,539 | Orange Vélodrome | Jérôme Brisard | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 15:00 | Saint-Étienne | 1.3 | 3–2 | 1.1 | Clermont Foot | Stade Geoffroy-Guichard | Pierre Gaillouste | Match Report | ||
| Ligue 1 | 13 | Sun | 2021-11-07 | 15:00 | Lorient | 1.3 | 1–2 | 2.6 | Brest | 14,649 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 15:00 | Reims | 0.3 | 0–0 | 1.0 | Monaco | 12,080 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 15:00 | Nantes | 2.3 | 2–2 | 2.1 | Strasbourg | 18,853 | Stade de la Beaujoire - Louis Fonteneau | Clément Turpin | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 17:00 | Nice | 1.4 | 0–1 | 0.4 | Montpellier | 20,157 | Stade de Nice | Antony Gautier | Match Report | |
| Ligue 1 | 13 | Sun | 2021-11-07 | 20:45 | Rennes | 3.3 | 4–1 | 1.1 | Lyon | 28,222 | Roazhon Park | Benoît Bastien | Match Report | |
| Ligue 1 | 14 | Fri | 2021-11-19 | 21:00 | Monaco | 1.1 | 2–2 | 2.2 | Lille | 3,778 | Stade Louis II | Willy Delajod | Match Report | |
| Ligue 1 | 14 | Sat | 2021-11-20 | 17:00 | Paris S-G | 1.8 | 3–1 | 1.4 | Nantes | 47,777 | Parc des Princes | Jeremy Stinat | Match Report | |
| Ligue 1 | 14 | Sat | 2021-11-20 | 21:00 | Rennes | 2.9 | 2–0 | 0.7 | Montpellier | 27,003 | Roazhon Park | Mikael Lesage | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 13:00 | Brest | 1.3 | 4–0 | 1.5 | Lens | 12,462 | Stade Francis-Le Blé | Eric Wattellier | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 15:00 | Metz | 1.2 | 3–3 | 2.2 | Bordeaux | 16,077 | Stade Saint-Symphorien | Benoît Millot | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 15:00 | Angers | 1.4 | 1–0 | 0.7 | Lorient | 6,971 | Stade Raymond Kopa | Pierre Gaillouste | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 15:00 | Troyes | 1.1 | 0–1 | 1.1 | Saint-Étienne | 10,644 | Stade de l'Aube | Florent Batta | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 15:00 | Strasbourg | 1.7 | 1–1 | 0.9 | Reims | 24,439 | Stade de la Meinau | Amaury Delerue | Match Report | |
| Ligue 1 | 14 | Sun | 2021-11-21 | 17:00 | Clermont Foot | 0.7 | 1–2 | 0.6 | Nice | 11,683 | Stade Gabriel Montpied | Stéphanie Frappart | Match Report | |
| Ligue 1 | 15 | Fri | 2021-11-26 | 21:00 | Lens | 1.3 | 2–2 | 1.5 | Angers | 35,713 | Stade Bollaert-Delelis | Florent Batta | Match Report | |
| Ligue 1 | 15 | Sat | 2021-11-27 | 17:00 | Lille | 1.2 | 1–1 | 0.5 | Nantes | 30,419 | Stade Pierre-Mauroy | Johan Hamel | Match Report | |
| Ligue 1 | 15 | Sat | 2021-11-27 | 21:00 | Nice | 1.2 | 0–1 | 0.4 | Metz | 17,033 | Stade de Nice | François Letexier | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 13:00 | Saint-Étienne | 0.8 | 1–3 | 2.7 | Paris S-G | 24,586 | Stade Geoffroy-Guichard | Jérôme Brisard | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 15:00 | Reims | 0.6 | 1–0 | 0.5 | Clermont Foot | 8,420 | Stade Auguste-Delaune | Benoît Bastien | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 15:00 | Lorient | 0.8 | 0–2 | 1.3 | Rennes | 16,321 | Stade du Moustoir | Bastien Dechepy | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 15:00 | Bordeaux | 1.4 | 1–2 | 2.4 | Brest | 15,280 | Stade Matmut-Atlantique | Pierre Gaillouste | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 15:00 | Monaco | 2.1 | 1–1 | 1.0 | Strasbourg | 3,478 | Stade Louis II | Antony Gautier | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 17:00 | Montpellier | 1.2 | 0–1 | 0.9 | Lyon | 14,747 | Stade de la Mosson | Thomas Léonard | Match Report | |
| Ligue 1 | 15 | Sun | 2021-11-28 | 20:45 | Marseille | 1.6 | 1–0 | 0.1 | Troyes | Orange Vélodrome | Jérémie Pignard | Match Report | ||
| Ligue 1 | 16 | Wed | 2021-12-01 | 19:00 | Angers | 1.3 | 1–3 | 3.1 | Monaco | 8,267 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 19:00 | Troyes | 1.0 | 2–0 | 0.4 | Lorient | 6,506 | Stade de l'Aube | Jeremy Stinat | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 19:00 | Strasbourg | 2.8 | 5–2 | 1.1 | Bordeaux | 24,378 | Stade de la Meinau | Willy Delajod | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 19:00 | Brest | 1.5 | 1–0 | 0.6 | Saint-Étienne | 13,248 | Stade Francis-Le Blé | Mikael Lesage | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 19:00 | Metz | 1.3 | 1–3 | 1.3 | Montpellier | 13,992 | Stade Saint-Symphorien | Ruddy Buquet | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 21:00 | Rennes | 0.8 | 1–2 | 0.7 | Lille | 25,392 | Roazhon Park | Stéphanie Frappart | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 21:00 | Nantes | 0.1 | 0–1 | 1.1 | Marseille | 34,018 | Stade de la Beaujoire - Louis Fonteneau | Eric Wattellier | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 21:00 | Paris S-G | 1.9 | 0–0 | 1.0 | Nice | 47,502 | Parc des Princes | Clément Turpin | Match Report | |
| Ligue 1 | 16 | Wed | 2021-12-01 | 21:00 | Lyon | 2.6 | 1–2 | 1.2 | Reims | Groupama Stadium | Benoît Millot | Match Report | ||
| Ligue 1 | 16 | Wed | 2021-12-01 | 21:00 | Clermont Foot | 1.7 | 2–2 | 0.7 | Lens | 11,948 | Stade Gabriel Montpied | Amaury Delerue | Match Report | |
| Ligue 1 | 17 | Sat | 2021-12-04 | 17:00 | Marseille | 1.5 | 1–2 | 1.3 | Brest | 54,413 | Orange Vélodrome | Antony Gautier | Match Report | |
| Ligue 1 | 17 | Sat | 2021-12-04 | 19:00 | Lille | 1.4 | 2–1 | 0.3 | Troyes | 28,286 | Stade Pierre-Mauroy | Benoît Bastien | Match Report | |
| Ligue 1 | 17 | Sat | 2021-12-04 | 21:00 | Lens | 1.1 | 1–1 | 1.9 | Paris S-G | 36,685 | Stade Bollaert-Delelis | François Letexier | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 13:00 | Saint-Étienne | 0.5 | 0–5 | 2.6 | Rennes | 11,257 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 15:00 | Montpellier | 0.9 | 1–0 | 0.4 | Clermont Foot | 9,643 | Stade de la Mosson | Florent Batta | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 15:00 | Monaco | 1.6 | 4–0 | 0.6 | Metz | 4,923 | Stade Louis II | Bastien Dechepy | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 15:00 | Reims | 1.2 | 1–2 | 2.2 | Angers | 8,238 | Stade Auguste-Delaune | Johan Hamel | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 15:00 | Lorient | 0.9 | 0–1 | 0.2 | Nantes | 16,025 | Stade du Moustoir | Ruddy Buquet | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 17:00 | Nice | 1.3 | 0–3 | 2.6 | Strasbourg | 16,220 | Stade de Nice | Jérémie Pignard | Match Report | |
| Ligue 1 | 17 | Sun | 2021-12-05 | 20:45 | Bordeaux | 2.6 | 2–2 | 2.3 | Lyon | 25,210 | Stade Matmut-Atlantique | Jérôme Brisard | Match Report | |
| Ligue 1 | 18 | Fri | 2021-12-10 | 21:00 | Nantes | 1.4 | 3–2 | 1.0 | Lens | 21,890 | Stade de la Beaujoire - Louis Fonteneau | Stéphanie Frappart | Match Report | |
| Ligue 1 | 18 | Sat | 2021-12-11 | 17:00 | Brest | 0.9 | 0–4 | 1.6 | Montpellier | 13,111 | Stade Francis-Le Blé | Benoît Millot | Match Report | |
| Ligue 1 | 18 | Sat | 2021-12-11 | 21:00 | Reims | 2.3 | 2–0 | 0.1 | Saint-Étienne | 12,019 | Stade Auguste-Delaune | Pierre Gaillouste | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 13:00 | Lille | 1.5 | 0–0 | 0.4 | Lyon | 40,248 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 15:00 | Angers | 1.7 | 0–1 | 1.7 | Clermont Foot | 8,149 | Stade Raymond Kopa | Jeremy Stinat | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 15:00 | Rennes | 1.6 | 1–2 | 1.4 | Nice | 27,892 | Roazhon Park | Willy Delajod | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 15:00 | Troyes | 1.5 | 1–2 | 1.3 | Bordeaux | 7,950 | Stade de l'Aube | Romain Lissorgue | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 15:00 | Metz | 1.1 | 4–1 | 1.4 | Lorient | 14,037 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 17:00 | Strasbourg | 1.9 | 0–2 | 0.7 | Marseille | 26,028 | Stade de la Meinau | Mikael Lesage | Match Report | |
| Ligue 1 | 18 | Sun | 2021-12-12 | 20:45 | Paris S-G | 1.6 | 2–0 | 0.7 | Monaco | 41,154 | Parc des Princes | Benoît Bastien | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Lyon | 2.3 | 1–1 | 0.5 | Metz | 34,867 | Groupama Stadium | Pierre Gaillouste | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Saint-Étienne | 1.0 | 0–1 | 0.9 | Nantes | 23,681 | Stade Geoffroy-Guichard | Clément Turpin | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Lorient | 1.6 | 1–1 | 1.8 | Paris S-G | 16,603 | Stade du Moustoir | Jérémie Pignard | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Nice | 0.9 | 2–1 | 1.0 | Lens | 22,065 | Stade de Nice | Jérôme Brisard | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Monaco | 1.8 | 2–1 | 1.4 | Rennes | 5,354 | Stade Louis II | Ruddy Buquet | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Marseille | 1.4 | 1–1 | 0.8 | Reims | 55,908 | Orange Vélodrome | François Letexier | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Montpellier | 1.1 | 4–1 | 0.6 | Angers | 10,990 | Stade de la Mosson | Hugo Miguel | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Troyes | 1.2 | 1–1 | 0.6 | Brest | 6,872 | Stade de l'Aube | Johan Hamel | Match Report | |
| Ligue 1 | 19 | Wed | 2021-12-22 | 21:00 | Bordeaux | 1.2 | 2–3 | 1.3 | Lille | 39,967 | Stade Matmut-Atlantique | Mikael Lesage | Match Report | |
| Ligue 1 | 20 | Fri | 2022-01-07 | 21:00 | Bordeaux | 0.5 | 0–1 | 2.4 | Marseille | Stade Matmut-Atlantique | Eric Wattellier | Match Report | ||
| Ligue 1 | 20 | Sat | 2022-01-08 | 21:00 | Lens | 0.8 | 1–0 | 0.5 | Rennes | 5,000 | Stade Bollaert-Delelis | Benoît Bastien | Match Report | |
| Ligue 1 | 20 | Sun | 2022-01-09 | 13:00 | Brest | 1.6 | 0–3 | 1.2 | Nice | 5,102 | Stade Francis-Le Blé | Stéphanie Frappart | Match Report | |
| Ligue 1 | 20 | Sun | 2022-01-09 | 15:00 | Metz | 0.3 | 0–2 | 2.6 | Strasbourg | 5,000 | Stade Saint-Symphorien | Antony Gautier | Match Report | |
| Ligue 1 | 20 | Sun | 2022-01-09 | 15:00 | Clermont Foot | 0.9 | 0–0 | 0.9 | Reims | 4,923 | Stade Gabriel Montpied | Romain Lissorgue | Match Report | |
| Ligue 1 | 20 | Sun | 2022-01-09 | 17:05 | Nantes | 0.4 | 0–0 | 0.8 | Monaco | 4,133 | Stade de la Beaujoire - Louis Fonteneau | Thomas Léonard | Match Report | |
| Ligue 1 | 20 | Sun | 2022-01-09 | 20:45 | Lyon | 1.0 | 1–1 | 1.0 | Paris S-G | 4,977 | Groupama Stadium | François Letexier | Match Report | |
| Ligue 1 | 21 | Fri | 2022-01-14 | 21:00 | Nice | 1.7 | 2–1 | 0.4 | Nantes | 5,000 | Stade de Nice | Ruddy Buquet | Match Report | |
| Ligue 1 | 21 | Sat | 2022-01-15 | 17:00 | Saint-Étienne | 1.3 | 1–2 | 0.9 | Lens | 5,000 | Stade Geoffroy-Guichard | François Letexier | Match Report | |
| Ligue 1 | 21 | Sat | 2022-01-15 | 21:00 | Paris S-G | 2.0 | 2–0 | 1.0 | Brest | 4,925 | Parc des Princes | Mikael Lesage | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 13:00 | Rennes | 3.1 | 6–0 | 0.3 | Bordeaux | 4,951 | Roazhon Park | Bastien Dechepy | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 15:00 | Reims | 0.6 | 0–1 | 0.8 | Metz | 3,923 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 15:00 | Monaco | 3.6 | 4–0 | 0.4 | Clermont Foot | 2,633 | Stade Louis II | Jeremy Stinat | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 15:00 | Lorient | 0.5 | 0–0 | 0.4 | Angers | 4,387 | Stade du Moustoir | Johan Hamel | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 15:00 | Strasbourg | 1.6 | 3–1 | 0.6 | Montpellier | 5,217 | Stade de la Meinau | Pierre Gaillouste | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 17:05 | Troyes | 0.4 | 0–1 | 2.8 | Lyon | 4,224 | Stade de l'Aube | Jérôme Brisard | Match Report | |
| Ligue 1 | 21 | Sun | 2022-01-16 | 20:45 | Marseille | 1.7 | 1–1 | 0.7 | Lille | 5,034 | Orange Vélodrome | Amaury Delerue | Match Report | |
| Ligue 1 | 19 | Wed | 2022-01-19 | 19:00 | Clermont Foot | 0.6 | 0–2 | 1.5 | Strasbourg | 4,219 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| Ligue 1 | 20 | Wed | 2022-01-19 | 19:00 | Montpellier | 0.9 | 0–1 | 0.8 | Troyes | 4,943 | Stade de la Mosson | Jeremy Stinat | Match Report | |
| Ligue 1 | 20 | Wed | 2022-01-19 | 19:00 | Lille | 1.7 | 3–1 | 1.1 | Lorient | 4,834 | Stade Pierre-Mauroy | Florent Batta | Match Report | |
| Ligue 1 | 22 | Fri | 2022-01-21 | 21:00 | Lyon | 1.8 | 1–0 | 0.3 | Saint-Étienne | 5,000 | Groupama Stadium | Antony Gautier | Match Report | |
| Ligue 1 | 22 | Sat | 2022-01-22 | 17:00 | Brest | 1.2 | 2–0 | 1.2 | Lille | 4,358 | Stade Francis-Le Blé | Jérôme Brisard | Match Report | |
| Ligue 1 | 22 | Sat | 2022-01-22 | 21:00 | Lens | 0.8 | 0–2 | 1.3 | Marseille | 5,000 | Stade Bollaert-Delelis | Stéphanie Frappart | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 13:00 | Metz | 0.4 | 0–2 | 1.9 | Nice | 5,000 | Stade Saint-Symphorien | Amaury Delerue | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 15:00 | Clermont Foot | 1.1 | 2–1 | 1.7 | Rennes | 4,535 | Stade Gabriel Montpied | Thomas Léonard | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 15:00 | Nantes | 0.9 | 4–2 | 2.1 | Lorient | 4,275 | Stade de la Beaujoire - Louis Fonteneau | Pierre Gaillouste | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 15:00 | Angers | 2.4 | 2–1 | 1.7 | Troyes | 5,000 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 15:00 | Bordeaux | 1.9 | 4–3 | 1.9 | Strasbourg | 3,308 | Stade Matmut-Atlantique | Mikael Lesage | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 17:05 | Montpellier | 1.7 | 3–2 | 1.2 | Monaco | 5,000 | Stade de la Mosson | Jérémie Pignard | Match Report | |
| Ligue 1 | 22 | Sun | 2022-01-23 | 20:45 | Paris S-G | 2.3 | 4–0 | 0.5 | Reims | 5,000 | Parc des Princes | Eric Wattellier | Match Report | |
| Ligue 1 | 20 | Wed | 2022-01-26 | 19:00 | Angers | 0.4 | 0–1 | 0.4 | Saint-Étienne | Stade Raymond Kopa | Clément Turpin | Match Report | ||
| Ligue 1 | 14 | Tue | 2022-02-01 | 21:00 | Lyon | 1.2 | 2–1 | 0.4 | Marseille | Groupama Stadium | Benoît Bastien | Match Report | ||
| Ligue 1 | 23 | Fri | 2022-02-04 | 21:00 | Marseille | 2.6 | 5–2 | 0.4 | Angers | 60,000 | Orange Vélodrome | Jeremy Stinat | Match Report | |
| Ligue 1 | 23 | Sat | 2022-02-05 | 17:00 | Saint-Étienne | 2.0 | 3–1 | 0.6 | Montpellier | 20,000 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| Ligue 1 | 23 | Sat | 2022-02-05 | 21:00 | Monaco | 2.3 | 2–0 | 1.3 | Lyon | 6,550 | Stade Louis II | Ruddy Buquet | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 13:00 | Lorient | 1.5 | 2–0 | 0.4 | Lens | 10,687 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 15:00 | Reims | 2.0 | 5–0 | 0.1 | Bordeaux | 8,858 | Stade Auguste-Delaune | Antony Gautier | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 15:00 | Nice | 1.0 | 0–1 | 1.5 | Clermont Foot | 18,022 | Stade de Nice | Jérôme Brisard | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 15:00 | Troyes | 0.6 | 0–0 | 0.5 | Metz | 7,227 | Stade de l'Aube | Pierre Gaillouste | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 15:00 | Strasbourg | 1.4 | 1–0 | 0.4 | Nantes | 22,240 | Stade de la Meinau | Amaury Delerue | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 17:00 | Rennes | 2.1 | 2–0 | 0.4 | Brest | 25,409 | Roazhon Park | Johan Hamel | Match Report | |
| Ligue 1 | 23 | Sun | 2022-02-06 | 20:45 | Lille | 1.0 | 1–5 | 3.9 | Paris S-G | 48,437 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| Ligue 1 | 24 | Fri | 2022-02-11 | 21:00 | Paris S-G | 0.9 | 1–0 | 0.8 | Rennes | 47,000 | Parc des Princes | Benoît Bastien | Match Report | |
| Ligue 1 | 24 | Sat | 2022-02-12 | 17:00 | Montpellier | 1.0 | 0–1 | 1.3 | Lille | 11,784 | Stade de la Mosson | Stéphanie Frappart | Match Report | |
| Ligue 1 | 24 | Sat | 2022-02-12 | 21:00 | Lyon | 2.4 | 2–0 | 0.1 | Nice | 41,974 | Groupama Stadium | Benoît Millot | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 13:00 | Monaco | 1.2 | 0–0 | 0.1 | Lorient | 3,963 | Stade Louis II | Bastien Dechepy | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 15:00 | Angers | 0.5 | 0–1 | 0.3 | Strasbourg | 6,521 | Stade Raymond Kopa | Pierre Gaillouste | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 15:00 | Brest | 2.7 | 5–1 | 0.5 | Troyes | 10,600 | Stade Francis-Le Blé | Florent Batta | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 15:00 | Nantes | 0.5 | 1–0 | 0.4 | Reims | 14,304 | Stade de la Beaujoire - Louis Fonteneau | Johan Hamel | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 15:00 | Clermont Foot | 0.9 | 1–2 | 0.7 | Saint-Étienne | 12,131 | Stade Gabriel Montpied | Ruddy Buquet | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 17:05 | Lens | 2.1 | 3–2 | 0.9 | Bordeaux | 32,662 | Stade Bollaert-Delelis | François Letexier | Match Report | |
| Ligue 1 | 24 | Sun | 2022-02-13 | 20:45 | Metz | 0.9 | 1–2 | 1.2 | Marseille | 25,482 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| Ligue 1 | 25 | Fri | 2022-02-18 | 21:00 | Lille | 1.1 | 0–0 | 0.4 | Metz | 30,384 | Stade Pierre-Mauroy | Bastien Dechepy | Match Report | |
| Ligue 1 | 25 | Sat | 2022-02-19 | 17:00 | Lens | 1.2 | 1–1 | 1.4 | Lyon | 36,624 | Stade Bollaert-Delelis | Jérôme Brisard | Match Report | |
| Ligue 1 | 25 | Sat | 2022-02-19 | 21:00 | Nantes | 2.4 | 3–1 | 3.4 | Paris S-G | 35,500 | Stade de la Beaujoire - Louis Fonteneau | Mikael Lesage | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 13:00 | Nice | 0.8 | 1–0 | 0.8 | Angers | 18,257 | Stade de Nice | Romain Lissorgue | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 15:00 | Saint-Étienne | 1.1 | 2–2 | 0.8 | Strasbourg | 24,897 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 15:00 | Reims | 0.7 | 1–1 | 1.7 | Brest | 9,307 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 15:00 | Rennes | 2.8 | 4–1 | 0.6 | Troyes | 22,967 | Roazhon Park | Clément Turpin | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 15:00 | Lorient | 0.8 | 0–1 | 0.4 | Montpellier | 10,135 | Stade du Moustoir | Jeremy Stinat | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 17:05 | Bordeaux | 0.5 | 1–1 | 1.8 | Monaco | 29,557 | Stade Matmut-Atlantique | Jérémie Pignard | Match Report | |
| Ligue 1 | 25 | Sun | 2022-02-20 | 20:45 | Marseille | 1.2 | 0–2 | 0.8 | Clermont Foot | 53,840 | Orange Vélodrome | Willy Delajod | Match Report | |
| Ligue 1 | 26 | Fri | 2022-02-25 | 21:00 | Montpellier | 1.2 | 2–4 | 1.9 | Rennes | 10,000 | Stade de la Mosson | Amaury Delerue | Match Report | |
| Ligue 1 | 26 | Sat | 2022-02-26 | 17:00 | Strasbourg | 0.8 | 0–0 | 0.2 | Nice | 25,150 | Stade de la Meinau | Stéphanie Frappart | Match Report | |
| Ligue 1 | 26 | Sat | 2022-02-26 | 21:00 | Paris S-G | 2.1 | 3–1 | 0.8 | Saint-Étienne | 45,000 | Parc des Princes | Pierre Gaillouste | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 13:00 | Monaco | 1.2 | 1–2 | 1.4 | Reims | 3,982 | Stade Louis II | Benoît Millot | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 15:00 | Angers | 0.6 | 1–2 | 0.6 | Lens | 9,499 | Stade Raymond Kopa | Thomas Léonard | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 15:00 | Metz | 0.5 | 0–0 | 0.6 | Nantes | 15,851 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 15:00 | Clermont Foot | 0.7 | 1–1 | 0.8 | Bordeaux | 12,032 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 15:00 | Brest | 0.2 | 0–1 | 2.5 | Lorient | 14,050 | Stade Francis-Le Blé | Benoît Bastien | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 17:05 | Troyes | 1.5 | 1–1 | 1.2 | Marseille | 16,871 | Stade de l'Aube | François Letexier | Match Report | |
| Ligue 1 | 26 | Sun | 2022-02-27 | 20:45 | Lyon | 1.4 | 0–1 | 0.7 | Lille | 42,647 | Groupama Stadium | Clément Turpin | Match Report | |
| Ligue 1 | 27 | Fri | 2022-03-04 | 21:00 | Lorient | 1.5 | 1–4 | 2.1 | Lyon | 13,497 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| Ligue 1 | 27 | Sat | 2022-03-05 | 17:00 | Lens | 2.0 | 0–1 | 0.5 | Brest | 36,305 | Stade Bollaert-Delelis | Johan Hamel | Match Report | |
| Ligue 1 | 27 | Sat | 2022-03-05 | 21:00 | Nice | 0.9 | 1–0 | 0.4 | Paris S-G | 31,949 | Stade de Nice | Willy Delajod | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 13:00 | Saint-Étienne | 1.4 | 1–0 | 0.5 | Metz | 35,706 | Stade Geoffroy-Guichard | Jeremy Stinat | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 15:00 | Nantes | 1.7 | 2–0 | 0.2 | Montpellier | 21,589 | Stade de la Beaujoire - Louis Fonteneau | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 15:00 | Reims | 0.9 | 1–1 | 0.7 | Strasbourg | 10,405 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 15:00 | Rennes | 1.6 | 2–0 | 0.6 | Angers | 27,693 | Roazhon Park | Benoît Millot | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 15:00 | Bordeaux | 0.7 | 0–2 | 2.2 | Troyes | 20,287 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 17:05 | Lille | 2.0 | 4–0 | 0.9 | Clermont Foot | 33,515 | Stade Pierre-Mauroy | Thomas Léonard | Match Report | |
| Ligue 1 | 27 | Sun | 2022-03-06 | 20:45 | Marseille | 0.7 | 0–1 | 0.8 | Monaco | 56,510 | Orange Vélodrome | Antony Gautier | Match Report | |
| Ligue 1 | 28 | Fri | 2022-03-11 | 21:00 | Lille | 1.0 | 0–0 | 0.4 | Saint-Étienne | 40,146 | Stade Pierre-Mauroy | Florent Batta | Match Report | |
| Ligue 1 | 28 | Sat | 2022-03-12 | 17:00 | Montpellier | 2.9 | 0–0 | 0.8 | Nice | 11,658 | Stade de la Mosson | Clément Turpin | Match Report | |
| Ligue 1 | 28 | Sat | 2022-03-12 | 21:00 | Troyes | 1.6 | 1–0 | 0.4 | Nantes | 7,400 | Stade de l'Aube | Stéphanie Frappart | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 13:00 | Paris S-G | 1.2 | 3–0 | 0.8 | Bordeaux | 44,000 | Parc des Princes | François Letexier | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 15:00 | Strasbourg | 0.8 | 1–0 | 0.8 | Monaco | 25,231 | Stade de la Meinau | Eric Wattellier | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 15:00 | Clermont Foot | 1.0 | 0–2 | 1.0 | Lorient | 11,359 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 15:00 | Metz | 0.7 | 0–0 | 0.5 | Lens | 15,687 | Stade Saint-Symphorien | Amaury Delerue | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 15:00 | Angers | 2.1 | 0–1 | 1.5 | Reims | 5,960 | Stade Raymond Kopa | Mikael Lesage | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 17:05 | Lyon | 1.3 | 2–4 | 1.5 | Rennes | 46,597 | Groupama Stadium | Antony Gautier | Match Report | |
| Ligue 1 | 28 | Sun | 2022-03-13 | 20:45 | Brest | 0.6 | 1–4 | 2.2 | Marseille | 14,611 | Stade Francis-Le Blé | Ruddy Buquet | Match Report | |
| Ligue 1 | 29 | Fri | 2022-03-18 | 21:00 | Saint-Étienne | 1.3 | 1–1 | 1.0 | Troyes | 32,193 | Stade Geoffroy-Guichard | Romain Lissorgue | Match Report | |
| Ligue 1 | 29 | Sat | 2022-03-19 | 17:00 | Lens | 1.2 | 3–1 | 1.4 | Clermont Foot | 36,182 | Stade Bollaert-Delelis | Jeremy Stinat | Match Report | |
| Ligue 1 | 29 | Sat | 2022-03-19 | 21:00 | Nantes | 0.8 | 0–1 | 1.1 | Lille | 25,977 | Stade de la Beaujoire - Louis Fonteneau | Pierre Gaillouste | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 13:00 | Monaco | 1.9 | 3–0 | 1.0 | Paris S-G | 16,642 | Stade Louis II | Benoît Bastien | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 15:00 | Angers | 1.8 | 1–0 | 1.2 | Brest | 7,734 | Stade Raymond Kopa | Jérémie Pignard | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 15:00 | Rennes | 3.5 | 6–1 | 0.7 | Metz | 27,966 | Roazhon Park | Willy Delajod | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 15:00 | Bordeaux | 3.5 | 0–2 | 0.4 | Montpellier | 15,000 | Stade Matmut-Atlantique | Thomas Léonard | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 15:00 | Lorient | 0.3 | 0–0 | 1.1 | Strasbourg | 9,806 | Stade du Moustoir | Benoît Millot | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 17:05 | Reims | 0.5 | 0–0 | 1.5 | Lyon | 14,091 | Stade Auguste-Delaune | Johan Hamel | Match Report | |
| Ligue 1 | 29 | Sun | 2022-03-20 | 20:45 | Marseille | 1.5 | 2–1 | 1.4 | Nice | 64,722 | Orange Vélodrome | Jérôme Brisard | Match Report | |
| Ligue 1 | 30 | Sat | 2022-04-02 | 17:00 | Nice | 0.8 | 1–1 | 1.1 | Rennes | 24,086 | Stade de Nice | Benoît Bastien | Match Report | |
| Ligue 1 | 30 | Sat | 2022-04-02 | 19:00 | Lille | 2.7 | 0–0 | 0.0 | Bordeaux | 36,351 | Stade Pierre-Mauroy | Bastien Dechepy | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 13:00 | Strasbourg | 2.5 | 1–0 | 0.9 | Lens | 26,005 | Stade de la Meinau | François Letexier | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 15:00 | Metz | 0.9 | 1–2 | 1.5 | Monaco | 19,812 | Stade Saint-Symphorien | Jérôme Brisard | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 15:00 | Saint-Étienne | 0.2 | 2–4 | 3.9 | Marseille | 41,278 | Stade Geoffroy-Guichard | Clément Turpin | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 15:00 | Troyes | 1.1 | 1–0 | 0.6 | Reims | 9,482 | Stade de l'Aube | Ruddy Buquet | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 15:00 | Montpellier | 1.4 | 1–2 | 0.7 | Brest | 10,929 | Stade de la Mosson | Florent Batta | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 15:00 | Clermont Foot | 0.9 | 2–3 | 2.0 | Nantes | 11,785 | Stade Gabriel Montpied | Mikael Lesage | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 17:05 | Lyon | 1.7 | 3–2 | 1.8 | Angers | 34,376 | Groupama Stadium | Eric Wattellier | Match Report | |
| Ligue 1 | 30 | Sun | 2022-04-03 | 20:45 | Paris S-G | 1.9 | 5–1 | 0.6 | Lorient | 40,000 | Parc des Princes | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 31 | Fri | 2022-04-08 | 21:00 | Lorient | 3.7 | 6–2 | 0.9 | Saint-Étienne | 15,407 | Stade du Moustoir | Ruddy Buquet | Match Report | |
| Ligue 1 | 31 | Sat | 2022-04-09 | 17:00 | Reims | 2.6 | 2–3 | 1.5 | Rennes | 10,243 | Stade Auguste-Delaune | Romain Lissorgue | Match Report | |
| Ligue 1 | 31 | Sat | 2022-04-09 | 21:00 | Clermont Foot | 1.4 | 1–6 | 3.7 | Paris S-G | 12,264 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 13:00 | Bordeaux | 2.0 | 3–1 | 0.5 | Metz | 21,652 | Stade Matmut-Atlantique | Jérémie Pignard | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 15:00 | Monaco | 0.4 | 2–1 | 1.0 | Troyes | 4,786 | Stade Louis II | Mikael Lesage | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 15:00 | Angers | 0.5 | 1–1 | 1.2 | Lille | 9,286 | Stade Raymond Kopa | Thomas Léonard | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 15:00 | Brest | 1.1 | 1–1 | 0.7 | Nantes | 13,145 | Stade Francis-Le Blé | Johan Hamel | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 17:05 | Lens | 0.9 | 3–0 | 1.4 | Nice | 36,668 | Stade Bollaert-Delelis | Willy Delajod | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 19:00 | Strasbourg | 1.0 | 1–1 | 1.5 | Lyon | 26,073 | Stade de la Meinau | Clément Turpin | Match Report | |
| Ligue 1 | 31 | Sun | 2022-04-10 | 21:00 | Marseille | 3.4 | 2–0 | 0.4 | Montpellier | 51,131 | Orange Vélodrome | Jeremy Stinat | Match Report | |
| Ligue 1 | 32 | Fri | 2022-04-15 | 21:00 | Rennes | 2.2 | 2–3 | 2.7 | Monaco | 28,336 | Roazhon Park | Stéphanie Frappart | Match Report | |
| Ligue 1 | 32 | Sat | 2022-04-16 | 17:00 | Saint-Étienne | 1.0 | 2–1 | 0.4 | Brest | 27,227 | Stade Geoffroy-Guichard | Eric Wattellier | Match Report | |
| Ligue 1 | 32 | Sat | 2022-04-16 | 21:00 | Lille | 0.8 | 1–2 | 1.2 | Lens | 48,169 | Stade Pierre-Mauroy | Jérôme Brisard | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 13:00 | Nice | 2.2 | 2–1 | 0.2 | Lorient | 17,212 | Stade de Nice | Amaury Delerue | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 15:00 | Nantes | 2.9 | 1–1 | 0.8 | Angers | 25,102 | Stade de la Beaujoire - Louis Fonteneau | Bastien Dechepy | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 15:00 | Metz | 0.3 | 1–1 | 2.4 | Clermont Foot | 14,335 | Stade Saint-Symphorien | Pierre Gaillouste | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 15:00 | Montpellier | 1.5 | 0–0 | 1.0 | Reims | 10,170 | Stade de la Mosson | Antony Gautier | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 15:00 | Troyes | 1.7 | 1–1 | 1.7 | Strasbourg | 10,000 | Stade de l'Aube | Benoît Millot | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 17:05 | Lyon | 1.7 | 6–1 | 2.2 | Bordeaux | 38,713 | Groupama Stadium | Florent Batta | Match Report | |
| Ligue 1 | 32 | Sun | 2022-04-17 | 20:45 | Paris S-G | 1.5 | 2–1 | 0.9 | Marseille | 46,000 | Parc des Princes | François Letexier | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 19:00 | Reims | 1.0 | 2–1 | 1.2 | Lille | 10,910 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 19:00 | Monaco | 1.7 | 1–0 | 0.7 | Nice | 10,247 | Stade Louis II | Benoît Millot | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 19:00 | Bordeaux | 0.9 | 2–2 | 0.9 | Saint-Étienne | 38,515 | Stade Matmut-Atlantique | Benoît Bastien | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 19:00 | Lorient | 1.8 | 1–0 | 1.4 | Metz | 13,544 | Stade du Moustoir | Mikael Lesage | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 19:00 | Troyes | 1.1 | 0–1 | 0.2 | Clermont Foot | 7,800 | Stade de l'Aube | Jérémie Pignard | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 21:00 | Angers | 0.8 | 0–3 | 1.7 | Paris S-G | 13,000 | Stade Raymond Kopa | Johan Hamel | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 21:00 | Strasbourg | 2.4 | 2–1 | 0.7 | Rennes | 25,148 | Stade de la Meinau | Willy Delajod | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 21:00 | Lens | 1.4 | 2–0 | 0.7 | Montpellier | 36,250 | Stade Bollaert-Delelis | Romain Lissorgue | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 21:00 | Brest | 1.2 | 2–1 | 2.7 | Lyon | 14,028 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| Ligue 1 | 33 | Wed | 2022-04-20 | 21:00 | Marseille | 3.3 | 3–2 | 0.6 | Nantes | 55,890 | Orange Vélodrome | Ruddy Buquet | Match Report | |
| Ligue 1 | 34 | Sat | 2022-04-23 | 17:00 | Lyon | 3.6 | 5–2 | 2.0 | Montpellier | 46,608 | Groupama Stadium | François Letexier | Match Report | |
| Ligue 1 | 34 | Sat | 2022-04-23 | 19:00 | Saint-Étienne | 1.1 | 1–4 | 3.3 | Monaco | 30,018 | Stade Geoffroy-Guichard | Bastien Dechepy | Match Report | |
| Ligue 1 | 34 | Sat | 2022-04-23 | 21:00 | Paris S-G | 2.0 | 1–1 | 0.8 | Lens | 47,000 | Parc des Princes | Amaury Delerue | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 13:00 | Rennes | 1.6 | 5–0 | 0.6 | Lorient | 28,324 | Roazhon Park | Benoît Millot | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 15:00 | Metz | 0.4 | 0–1 | 1.7 | Brest | 19,874 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 15:00 | Nantes | 2.5 | 5–3 | 2.8 | Bordeaux | 30,000 | Stade de la Beaujoire - Louis Fonteneau | Clément Turpin | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 15:00 | Nice | 2.0 | 1–0 | 0.4 | Troyes | 17,065 | Stade de Nice | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 15:00 | Clermont Foot | 2.1 | 2–2 | 1.3 | Angers | 11,531 | Stade Gabriel Montpied | Stéphanie Frappart | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 17:05 | Lille | 0.5 | 1–0 | 1.0 | Strasbourg | 30,211 | Stade Pierre-Mauroy | Jérémie Pignard | Match Report | |
| Ligue 1 | 34 | Sun | 2022-04-24 | 20:45 | Reims | 0.6 | 0–1 | 0.6 | Marseille | 20,835 | Stade Auguste-Delaune | Jérôme Brisard | Match Report | |
| Ligue 1 | 35 | Fri | 2022-04-29 | 21:00 | Strasbourg | 1.7 | 3–3 | 2.3 | Paris S-G | 26,052 | Stade de la Meinau | Ruddy Buquet | Match Report | |
| Ligue 1 | 35 | Sat | 2022-04-30 | 17:00 | Lens | 2.3 | 2–2 | 1.4 | Nantes | 36,727 | Stade Bollaert-Delelis | Thomas Léonard | Match Report | |
| Ligue 1 | 35 | Sat | 2022-04-30 | 21:00 | Rennes | 1.6 | 2–0 | 0.7 | Saint-Étienne | 27,390 | Roazhon Park | Jeremy Stinat | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 13:00 | Troyes | 2.9 | 3–0 | 0.5 | Lille | 10,497 | Stade de l'Aube | Willy Delajod | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 15:00 | Brest | 1.3 | 2–0 | 1.1 | Clermont Foot | 10,592 | Stade Francis-Le Blé | Romain Lissorgue | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 15:00 | Monaco | 2.6 | 2–0 | 0.7 | Angers | 4,616 | Stade Louis II | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 15:00 | Montpellier | 2.1 | 2–2 | 1.1 | Metz | 10,446 | Stade de la Mosson | Clément Turpin | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 15:00 | Lorient | 1.9 | 1–2 | 1.6 | Reims | 12,216 | Stade du Moustoir | Pierre Gaillouste | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 17:05 | Bordeaux | 0.3 | 0–1 | 2.7 | Nice | 23,552 | Stade Matmut-Atlantique | Johan Hamel | Match Report | |
| Ligue 1 | 35 | Sun | 2022-05-01 | 20:45 | Marseille | 1.4 | 0–3 | 2.4 | Lyon | 68,784 | Orange Vélodrome | Antony Gautier | Match Report | |
| Ligue 1 | 36 | Fri | 2022-05-06 | 21:00 | Lille | 1.0 | 1–2 | 0.3 | Monaco | 39,088 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| Ligue 1 | 36 | Sat | 2022-05-07 | 17:00 | Brest | 0.4 | 0–1 | 2.2 | Strasbourg | 12,093 | Stade Francis-Le Blé | Mikael Lesage | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 13:00 | Metz | 2.0 | 3–2 | 2.0 | Lyon | 20,405 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 15:00 | Clermont Foot | 2.2 | 2–1 | 1.2 | Montpellier | 11,587 | Stade Gabriel Montpied | Benoît Bastien | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 15:00 | Angers | 2.9 | 4–1 | 0.8 | Bordeaux | 10,852 | Stade Raymond Kopa | Benoît Millot | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 15:00 | Reims | 0.5 | 1–2 | 1.8 | Lens | 16,962 | Stade Auguste-Delaune | Vitor Ferreira Fernandes | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 17:05 | Lorient | 0.2 | 0–3 | 1.6 | Marseille | 16,210 | Stade du Moustoir | Bastien Dechepy | Match Report | |
| Ligue 1 | 36 | Sun | 2022-05-08 | 20:45 | Paris S-G | 2.4 | 2–2 | 1.7 | Troyes | 45,000 | Parc des Princes | Jérôme Brisard | Match Report | |
| Ligue 1 | 36 | Wed | 2022-05-11 | 19:00 | Nice | 1.4 | 4–2 | 2.1 | Saint-Étienne | 17,704 | Stade de Nice | Ruddy Buquet | Match Report | |
| Ligue 1 | 36 | Wed | 2022-05-11 | 21:00 | Nantes | 1.2 | 2–1 | 2.0 | Rennes | 26,359 | Stade de la Beaujoire - Louis Fonteneau | Antony Gautier | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Nice | 1.4 | 1–3 | 2.0 | Lille | 24,232 | Stade de Nice | Thomas Léonard | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Bordeaux | 1.0 | 0–0 | 0.6 | Lorient | 23,191 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Montpellier | 0.7 | 0–4 | 2.7 | Paris S-G | 19,586 | Stade de la Mosson | Jeremy Stinat | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Rennes | 1.6 | 2–0 | 0.4 | Marseille | 28,811 | Roazhon Park | Benoît Bastien | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Monaco | 3.1 | 4–2 | 1.9 | Brest | 6,000 | Stade Louis II | Jérôme Brisard | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Troyes | 0.3 | 1–3 | 0.8 | Lens | 19,000 | Stade de l'Aube | François Letexier | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Strasbourg | 0.9 | 1–0 | 0.7 | Clermont Foot | 25,231 | Stade de la Meinau | Benoît Millot | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Metz | 0.4 | 1–0 | 0.7 | Angers | 17,213 | Stade Saint-Symphorien | Jérémie Pignard | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Lyon | 2.2 | 3–2 | 2.0 | Nantes | 54,404 | Groupama Stadium | Florent Batta | Match Report | |
| Ligue 1 | 37 | Sat | 2022-05-14 | 21:00 | Saint-Étienne | 1.6 | 1–2 | 2.0 | Reims | Stade Geoffroy-Guichard | Clément Turpin | Match Report | ||
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Lille | 1.8 | 2–2 | 1.2 | Rennes | 40,116 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Brest | 0.9 | 2–4 | 2.8 | Bordeaux | 14,484 | Stade Francis-Le Blé | Hakim Ben El Hadj Salem | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Nantes | 2.0 | 1–1 | 1.6 | Saint-Étienne | 28,636 | Stade de la Beaujoire - Louis Fonteneau | François Letexier | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Clermont Foot | 2.3 | 1–2 | 2.0 | Lyon | 12,000 | Stade Gabriel Montpied | Mikael Lesage | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Angers | 2.5 | 2–0 | 1.6 | Montpellier | 11,249 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Lorient | 1.2 | 1–1 | 0.4 | Troyes | 15,131 | Stade du Moustoir | Johan Hamel | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Paris S-G | 5.4 | 5–0 | 0.7 | Metz | 45,000 | Parc des Princes | Antony Gautier | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Reims | 0.7 | 2–3 | 1.8 | Nice | 12,589 | Stade Auguste-Delaune | Eric Wattellier | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Marseille | 2.3 | 4–0 | 1.1 | Strasbourg | 63,873 | Orange Vélodrome | Stéphanie Frappart | Match Report | |
| Ligue 1 | 38 | Sat | 2022-05-21 | 21:00 | Lens | 1.6 | 2–2 | 1.4 | Monaco | 37,764 | Stade Bollaert-Delelis | Benoît Bastien | Match Report | |
| French 1/2 Relegation/Promotion Play-off | Thu | 2022-05-26 | 19:00 | Auxerre | 1–1 | Saint-Étienne | 17,479 | Stade de l'Abbé Deschamps | Match Report | Leg 1 of 2 | ||||
| French 1/2 Relegation/Promotion Play-off | Sun | 2022-05-29 | 19:00 | Saint-Étienne | (4) 1–1 (5) | Auxerre | 24,489 | Stade Geoffroy-Guichard | Match Report | Leg 2 of 2; Auxerre won; Auxerre won on penalty kicks following extra time |
| Wk | Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-06 | 21:00 | Monaco | 1.5 | 1–1 | 0.2 | Nantes | 7,500 | Stade Louis II | Antony Gautier | Match Report | |
| 1 | Sat | 2021-08-07 | 17:00 | Lyon | 1.4 | 1–1 | 0.8 | Brest | 29,018 | Groupama Stadium | Mikael Lesage | Match Report | |
| 1 | Sat | 2021-08-07 | 21:00 | Troyes | 0.9 | 1–2 | 1.2 | Paris S-G | 15,248 | Stade de l'Aube | Amaury Delerue | Match Report | |
| 1 | Sun | 2021-08-08 | 13:00 | Rennes | 0.7 | 1–1 | 2.1 | Lens | 22,567 | Roazhon Park | Bastien Dechepy | Match Report | |
| 1 | Sun | 2021-08-08 | 15:00 | Bordeaux | 0.7 | 0–2 | 3.1 | Clermont Foot | 18,748 | Stade Matmut-Atlantique | Florent Batta | Match Report | |
| 1 | Sun | 2021-08-08 | 15:00 | Strasbourg | 0.3 | 0–2 | 0.9 | Angers | 23,250 | Stade de la Meinau | Jeremy Stinat | Match Report | |
| 1 | Sun | 2021-08-08 | 15:00 | Nice | 0.8 | 0–0 | 0.2 | Reims | 18,030 | Stade de Nice | Johan Hamel | Match Report | |
| 1 | Sun | 2021-08-08 | 15:00 | Saint-Étienne | 1.9 | 1–1 | 0.6 | Lorient | 20,461 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| 1 | Sun | 2021-08-08 | 17:00 | Metz | 0.9 | 3–3 | 1.3 | Lille | 15,551 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| 1 | Sun | 2021-08-08 | 20:45 | Montpellier | 0.6 | 2–3 | 1.9 | Marseille | 13,500 | Stade de la Mosson | Jérémie Pignard | Match Report | |
| 2 | Fri | 2021-08-13 | 21:00 | Lorient | 0.8 | 1–0 | 1.1 | Monaco | 12,149 | Stade du Moustoir | Hakim Ben El Hadj Salem | Match Report | |
| 2 | Sat | 2021-08-14 | 17:00 | Lille | 0.8 | 0–4 | 1.9 | Nice | 30,144 | Stade Pierre-Mauroy | Jérôme Brisard | Match Report | |
| 2 | Sat | 2021-08-14 | 21:00 | Paris S-G | 3.1 | 4–2 | 0.7 | Strasbourg | 46,962 | Parc des Princes | Willy Delajod | Match Report | |
| 2 | Sun | 2021-08-15 | 13:00 | Angers | 1.8 | 3–0 | 0.9 | Lyon | 6,154 | Stade Raymond Kopa | Clément Turpin | Match Report | |
| 2 | Sun | 2021-08-15 | 15:00 | Clermont Foot | 1.9 | 2–0 | 0.7 | Troyes | 11,005 | Stade Gabriel Montpied | Romain Lissorgue | Match Report | |
| 2 | Sun | 2021-08-15 | 15:00 | Brest | 1.9 | 1–1 | 1.0 | Rennes | 14,271 | Stade Francis-Le Blé | Benoît Bastien | Match Report | |
| 2 | Sun | 2021-08-15 | 15:00 | Nantes | 1.7 | 2–0 | 0.6 | Metz | 12,054 | Stade de la Beaujoire - Louis Fonteneau | Johan Hamel | Match Report | |
| 2 | Sun | 2021-08-15 | 15:00 | Reims | 1.8 | 3–3 | 1.8 | Montpellier | 8,887 | Stade Auguste-Delaune | Jeremy Stinat | Match Report | |
| 2 | Sun | 2021-08-15 | 17:00 | Lens | 1.3 | 2–2 | 0.9 | Saint-Étienne | 35,541 | Stade Bollaert-Delelis | Amaury Delerue | Match Report | |
| 2 | Sun | 2021-08-15 | 20:45 | Marseille | 1.0 | 2–2 | 0.3 | Bordeaux | 50,000 | Orange Vélodrome | Ruddy Buquet | Match Report | |
| 3 | Fri | 2021-08-20 | 21:00 | Brest | 1.1 | 2–4 | 0.9 | Paris S-G | 14,586 | Stade Francis-Le Blé | Eric Wattellier | Match Report | |
| 3 | Sat | 2021-08-21 | 17:00 | Monaco | 0.3 | 0–2 | 0.5 | Lens | 6,483 | Stade Louis II | Jérémie Pignard | Match Report | |
| 3 | Sat | 2021-08-21 | 21:00 | Saint-Étienne | 0.5 | 1–1 | 1.0 | Lille | 20,673 | Stade Geoffroy-Guichard | Mikael Lesage | Match Report | |
| 3 | Sun | 2021-08-22 | 13:00 | Lyon | 3.3 | 3–3 | 1.4 | Clermont Foot | 34,713 | Groupama Stadium | Thomas Léonard | Match Report | |
| 3 | Sun | 2021-08-22 | 15:00 | Strasbourg | 2.2 | 1–1 | 1.4 | Troyes | 22,185 | Stade de la Meinau | Jérôme Brisard | Match Report | |
| 3 | Sun | 2021-08-22 | 15:00 | Metz | 0.5 | 1–1 | 0.9 | Reims | 14,799 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| 3 | Sun | 2021-08-22 | 15:00 | Montpellier | 3.0 | 3–1 | 0.6 | Lorient | 6,527 | Stade de la Mosson | Bastien Dechepy | Match Report | |
| 3 | Sun | 2021-08-22 | 15:00 | Bordeaux | 0.5 | 1–1 | 0.9 | Angers | 18,281 | Stade Matmut-Atlantique | Pierre Gaillouste | Match Report | |
| 3 | Sun | 2021-08-22 | 17:00 | Rennes | 0.9 | 1–0 | 0.5 | Nantes | 27,569 | Roazhon Park | Stéphanie Frappart | Match Report | |
| 4 | Fri | 2021-08-27 | 21:00 | Nantes | 1.4 | 0–1 | 1.2 | Lyon | 23,177 | Stade de la Beaujoire - Louis Fonteneau | Jérôme Brisard | Match Report | |
| 4 | Sat | 2021-08-28 | 17:00 | Nice | 3.2 | 4–0 | 1.1 | Bordeaux | Stade de Nice | Jérémie Pignard | Match Report | ||
| 4 | Sat | 2021-08-28 | 21:00 | Marseille | 2.1 | 3–1 | 1.1 | Saint-Étienne | 55,039 | Orange Vélodrome | Benoît Millot | Match Report | |
| 4 | Sun | 2021-08-29 | 13:00 | Troyes | 0.7 | 1–2 | 1.9 | Monaco | 9,866 | Stade de l'Aube | Johan Hamel | Match Report | |
| 4 | Sun | 2021-08-29 | 15:00 | Strasbourg | 1.4 | 3–1 | 0.8 | Brest | 22,341 | Stade de la Meinau | Romain Lissorgue | Match Report | |
| 4 | Sun | 2021-08-29 | 15:00 | Angers | 2.2 | 2–0 | 0.9 | Rennes | 6,473 | Stade Raymond Kopa | Antony Gautier | Match Report | |
| 4 | Sun | 2021-08-29 | 15:00 | Lens | 1.3 | 2–2 | 1.2 | Lorient | 35,029 | Stade Bollaert-Delelis | Willy Delajod | Match Report | |
| 4 | Sun | 2021-08-29 | 15:00 | Clermont Foot | 1.6 | 2–2 | 1.4 | Metz | 11,274 | Stade Gabriel Montpied | Hakim Ben El Hadj Salem | Match Report | |
| 4 | Sun | 2021-08-29 | 17:00 | Lille | 1.6 | 2–1 | 0.6 | Montpellier | 28,859 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| 4 | Sun | 2021-08-29 | 20:45 | Reims | 0.7 | 0–2 | 1.3 | Paris S-G | 20,525 | Stade Auguste-Delaune | François Letexier | Match Report | |
| 5 | Fri | 2021-09-10 | 21:00 | Lorient | 1.8 | 2–1 | 1.3 | Lille | 10,271 | Stade du Moustoir | Clément Turpin | Match Report | |
| 5 | Sat | 2021-09-11 | 17:00 | Paris S-G | 2.5 | 4–0 | 0.9 | Clermont Foot | 47,329 | Parc des Princes | Mikael Lesage | Match Report | |
| 5 | Sat | 2021-09-11 | 21:00 | Monaco | 0.8 | 0–2 | 1.6 | Marseille | 8,615 | Stade Louis II | Stéphanie Frappart | Match Report | |
| 5 | Sun | 2021-09-12 | 13:00 | Montpellier | 1.1 | 2–0 | 0.8 | Saint-Étienne | 10,402 | Stade de la Mosson | Benoît Bastien | Match Report | |
| 5 | Sun | 2021-09-12 | 15:00 | Rennes | 0.6 | 0–2 | 0.5 | Reims | 24,486 | Roazhon Park | Thomas Léonard | Match Report | |
| 5 | Sun | 2021-09-12 | 15:00 | Bordeaux | 0.8 | 2–3 | 2.5 | Lens | 19,763 | Stade Matmut-Atlantique | Luís Godinho | Match Report | |
| 5 | Sun | 2021-09-12 | 15:00 | Brest | 1.3 | 1–1 | 1.2 | Angers | 10,982 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| 5 | Sun | 2021-09-12 | 15:00 | Metz | 0.7 | 0–2 | 0.6 | Troyes | 15,269 | Stade Saint-Symphorien | Pierre Gaillouste | Match Report | |
| 5 | Sun | 2021-09-12 | 17:00 | Nantes | 1.7 | 0–2 | 2.1 | Nice | 14,597 | Stade de la Beaujoire - Louis Fonteneau | Benoît Millot | Match Report | |
| 5 | Sun | 2021-09-12 | 20:45 | Lyon | 1.6 | 3–1 | 1.6 | Strasbourg | 33,267 | Groupama Stadium | Ruddy Buquet | Match Report | |
| 6 | Fri | 2021-09-17 | 21:00 | Strasbourg | 2.0 | 3–0 | 0.6 | Metz | 25,437 | Stade de la Meinau | Eric Wattellier | Match Report | |
| 6 | Sat | 2021-09-18 | 17:00 | Lens | 0.6 | 1–0 | 0.7 | Lille | 36,512 | Stade Bollaert-Delelis | Benoît Millot | Match Report | |
| 6 | Sat | 2021-09-18 | 21:00 | Saint-Étienne | 1.4 | 1–2 | 2.3 | Bordeaux | 23,869 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| 6 | Sun | 2021-09-19 | 13:00 | Nice | 1.7 | 2–2 | 2.4 | Monaco | Stade de Nice | François Letexier | Match Report | ||
| 6 | Sun | 2021-09-19 | 15:00 | Troyes | 1.1 | 1–1 | 0.2 | Montpellier | 7,405 | Stade de l'Aube | Florent Batta | Match Report | |
| 6 | Sun | 2021-09-19 | 15:00 | Clermont Foot | 1.1 | 1–1 | 0.5 | Brest | 11,224 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| 6 | Sun | 2021-09-19 | 15:00 | Reims | 0.8 | 0–0 | 0.3 | Lorient | 9,443 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| 6 | Sun | 2021-09-19 | 15:00 | Angers | 0.9 | 1–4 | 2.1 | Nantes | 9,046 | Stade Raymond Kopa | Amaury Delerue | Match Report | |
| 6 | Sun | 2021-09-19 | 17:00 | Marseille | 2.1 | 2–0 | 1.5 | Rennes | 54,188 | Orange Vélodrome | Willy Delajod | Match Report | |
| 6 | Sun | 2021-09-19 | 20:45 | Paris S-G | 2.0 | 2–1 | 0.8 | Lyon | 47,611 | Parc des Princes | Clément Turpin | Match Report | |
| 7 | Wed | 2021-09-22 | 19:00 | Rennes | 2.4 | 6–0 | 0.3 | Clermont Foot | 24,109 | Roazhon Park | Benoît Bastien | Match Report | |
| 7 | Wed | 2021-09-22 | 19:00 | Nantes | 1.3 | 3–1 | 0.8 | Brest | 19,676 | Stade de la Beaujoire - Louis Fonteneau | Thomas Léonard | Match Report | |
| 7 | Wed | 2021-09-22 | 19:00 | Lille | 0.7 | 2–1 | 1.3 | Reims | 32,604 | Stade Pierre-Mauroy | Johan Hamel | Match Report | |
| 7 | Wed | 2021-09-22 | 19:00 | Montpellier | 1.3 | 3–3 | 1.2 | Bordeaux | 9,585 | Stade de la Mosson | Mikael Lesage | Match Report | |
| 7 | Wed | 2021-09-22 | 19:00 | Monaco | 1.7 | 3–1 | 0.4 | Saint-Étienne | 3,579 | Stade Louis II | Jérôme Brisard | Match Report | |
| 7 | Wed | 2021-09-22 | 21:00 | Lyon | 1.8 | 3–1 | 1.4 | Troyes | 29,714 | Groupama Stadium | Stéphanie Frappart | Match Report | |
| 7 | Wed | 2021-09-22 | 21:00 | Lens | 1.5 | 0–1 | 1.1 | Strasbourg | Stade Bollaert-Delelis | Jeremy Stinat | Match Report | ||
| 7 | Wed | 2021-09-22 | 21:00 | Lorient | 0.5 | 1–0 | 2.2 | Nice | 10,687 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| 7 | Wed | 2021-09-22 | 21:00 | Angers | 0.4 | 0–0 | 0.7 | Marseille | 12,458 | Stade Raymond Kopa | Ruddy Buquet | Match Report | |
| 7 | Wed | 2021-09-22 | 21:00 | Metz | 0.9 | 1–2 | 1.3 | Paris S-G | 2,661 | Stade Saint-Symphorien | Jérémie Pignard | Match Report | |
| 8 | Sat | 2021-09-25 | 17:00 | Saint-Étienne | 0.6 | 0–3 | 2.2 | Nice | 19,980 | Stade Geoffroy-Guichard | Amaury Delerue | Match Report | |
| 8 | Sat | 2021-09-25 | 19:00 | Strasbourg | 0.4 | 1–2 | 2.3 | Lille | 23,762 | Stade de la Meinau | François Letexier | Match Report | |
| 8 | Sat | 2021-09-25 | 21:00 | Paris S-G | 2.1 | 2–0 | 0.2 | Montpellier | 47,408 | Parc des Princes | Antony Gautier | Match Report | |
| 8 | Sat | 2021-09-25 | 21:00 | Lyon | 1.3 | 1–1 | 0.7 | Lorient | 36,424 | Groupama Stadium | Bastien Dechepy | Match Report | |
| 8 | Sun | 2021-09-26 | 13:00 | Bordeaux | 0.7 | 1–1 | 2.0 | Rennes | 16,675 | Stade Matmut-Atlantique | Hakim Ben El Hadj Salem | Match Report | |
| 8 | Sun | 2021-09-26 | 15:00 | Troyes | 1.0 | 1–1 | 1.3 | Angers | 6,868 | Stade de l'Aube | Thomas Léonard | Match Report | |
| 8 | Sun | 2021-09-26 | 15:00 | Brest | 1.6 | 1–2 | 0.6 | Metz | 10,398 | Stade Francis-Le Blé | Willy Delajod | Match Report | |
| 8 | Sun | 2021-09-26 | 15:00 | Reims | 1.1 | 3–1 | 0.6 | Nantes | 280 | Stade Auguste-Delaune | Eric Wattellier | Match Report | |
| 8 | Sun | 2021-09-26 | 17:00 | Clermont Foot | 1.1 | 1–3 | 1.6 | Monaco | 11,529 | Stade Gabriel Montpied | Benoît Millot | Match Report | |
| 8 | Sun | 2021-09-26 | 20:45 | Marseille | 2.0 | 2–3 | 2.0 | Lens | 50,001 | Orange Vélodrome | Mikael Lesage | Match Report | |
| 9 | Fri | 2021-10-01 | 21:00 | Lens | 2.1 | 2–0 | 0.1 | Reims | Stade Bollaert-Delelis | Benoît Bastien | Match Report | ||
| 9 | Sat | 2021-10-02 | 17:00 | Montpellier | 1.1 | 1–1 | 0.3 | Strasbourg | 9,851 | Stade de la Mosson | Hakim Ben El Hadj Salem | Match Report | |
| 9 | Sat | 2021-10-02 | 21:00 | Nice | 3.8 | 2–1 | 0.6 | Brest | 13,503 | Stade de Nice | António Nobre | Match Report | |
| 9 | Sun | 2021-10-03 | 13:00 | Rennes | 1.0 | 2–0 | 1.5 | Paris S-G | 28,092 | Roazhon Park | Ruddy Buquet | Match Report | |
| 9 | Sun | 2021-10-03 | 15:00 | Lorient | 0.5 | 1–1 | 1.1 | Clermont Foot | 12,611 | Stade du Moustoir | Pierre Gaillouste | Match Report | |
| 9 | Sun | 2021-10-03 | 15:00 | Monaco | 1.6 | 3–0 | 0.3 | Bordeaux | 3,667 | Stade Louis II | Clément Turpin | Match Report | |
| 9 | Sun | 2021-10-03 | 15:00 | Angers | 2.3 | 3–2 | 1.1 | Metz | 3,989 | Stade Raymond Kopa | Stéphanie Frappart | Match Report | |
| 9 | Sun | 2021-10-03 | 15:00 | Nantes | 1.9 | 2–0 | 1.3 | Troyes | 15,150 | Stade de la Beaujoire - Louis Fonteneau | Jérôme Brisard | Match Report | |
| 9 | Sun | 2021-10-03 | 17:00 | Lille | 3.0 | 2–0 | 0.4 | Marseille | 44,839 | Stade Pierre-Mauroy | Jérémie Pignard | Match Report | |
| 9 | Sun | 2021-10-03 | 20:45 | Saint-Étienne | 2.3 | 1–1 | 1.3 | Lyon | 33,643 | Stade Geoffroy-Guichard | François Letexier | Match Report | |
| 10 | Fri | 2021-10-15 | 21:00 | Paris S-G | 2.0 | 2–1 | 1.1 | Angers | 47,646 | Parc des Princes | Bastien Dechepy | Match Report | |
| 10 | Sat | 2021-10-16 | 17:00 | Clermont Foot | 0.3 | 1–0 | 0.9 | Lille | 11,537 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| 10 | Sat | 2021-10-16 | 21:00 | Lyon | 2.6 | 2–0 | 0.6 | Monaco | 50,585 | Groupama Stadium | Amaury Delerue | Match Report | |
| 10 | Sun | 2021-10-17 | 13:00 | Troyes | 0.9 | 1–0 | 0.6 | Nice | 7,925 | Stade de l'Aube | Johan Hamel | Match Report | |
| 10 | Sun | 2021-10-17 | 15:00 | Brest | 0.5 | 1–1 | 0.8 | Reims | 9,693 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| 10 | Sun | 2021-10-17 | 15:00 | Bordeaux | 0.5 | 1–1 | 1.3 | Nantes | 39,510 | Stade Matmut-Atlantique | Willy Delajod | Match Report | |
| 10 | Sun | 2021-10-17 | 15:00 | Metz | 0.9 | 0–3 | 2.2 | Rennes | 15,679 | Stade Saint-Symphorien | Benoît Millot | Match Report | |
| 10 | Sun | 2021-10-17 | 15:00 | Strasbourg | 2.1 | 5–1 | 1.0 | Saint-Étienne | 25,371 | Stade de la Meinau | Mikael Lesage | Match Report | |
| 10 | Sun | 2021-10-17 | 17:00 | Montpellier | 1.5 | 1–0 | 0.9 | Lens | 12,474 | Stade de la Mosson | Florent Batta | Match Report | |
| 10 | Sun | 2021-10-17 | 20:45 | Marseille | 1.8 | 4–1 | 2.2 | Lorient | 57,349 | Orange Vélodrome | Antony Gautier | Match Report | |
| 11 | Fri | 2021-10-22 | 21:00 | Saint-Étienne | 1.6 | 2–2 | 0.5 | Angers | 19,836 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| 11 | Sat | 2021-10-23 | 17:00 | Nantes | 1.3 | 2–1 | 1.1 | Clermont Foot | 19,968 | Stade de la Beaujoire - Louis Fonteneau | Romain Lissorgue | Match Report | |
| 11 | Sat | 2021-10-23 | 21:00 | Lille | 1.7 | 1–1 | 1.2 | Brest | 32,613 | Stade Pierre-Mauroy | Clément Turpin | Match Report | |
| 11 | Sun | 2021-10-24 | 13:00 | Nice | 2.4 | 3–2 | 1.4 | Lyon | 24,519 | Stade de Nice | Jérôme Brisard | Match Report | |
| 11 | Sun | 2021-10-24 | 15:00 | Rennes | 1.2 | 1–0 | 0.9 | Strasbourg | 27,185 | Roazhon Park | Stéphanie Frappart | Match Report | |
| 11 | Sun | 2021-10-24 | 15:00 | Lens | 1.8 | 4–1 | 0.8 | Metz | 35,673 | Stade Bollaert-Delelis | Jérémie Pignard | Match Report | |
| 11 | Sun | 2021-10-24 | 15:00 | Lorient | 1.2 | 1–1 | 1.0 | Bordeaux | 11,678 | Stade du Moustoir | Thomas Léonard | Match Report | |
| 11 | Sun | 2021-10-24 | 15:00 | Reims | 0.8 | 1–2 | 0.9 | Troyes | 12,326 | Stade Auguste-Delaune | Pierre Gaillouste | Match Report | |
| 11 | Sun | 2021-10-24 | 17:00 | Monaco | 1.3 | 3–1 | 1.3 | Montpellier | 4,861 | Stade Louis II | François Letexier | Match Report | |
| 11 | Sun | 2021-10-24 | 20:45 | Marseille | 1.1 | 0–0 | 1.4 | Paris S-G | 65,121 | Orange Vélodrome | Benoît Bastien | Match Report | |
| 3 | Wed | 2021-10-27 | 21:00 | Nice | 1.5 | 1–1 | 0.5 | Marseille | Stade de l'Aube (Neutral Site) | Clément Turpin | Match Report | ||
| 12 | Fri | 2021-10-29 | 21:00 | Paris S-G | 2.1 | 2–1 | 1.8 | Lille | 47,874 | Parc des Princes | Amaury Delerue | Match Report | |
| 12 | Sat | 2021-10-30 | 17:00 | Metz | 0.4 | 1–1 | 0.4 | Saint-Étienne | 15,914 | Stade Saint-Symphorien | Stéphanie Frappart | Match Report | |
| 12 | Sat | 2021-10-30 | 21:00 | Lyon | 1.9 | 2–1 | 2.1 | Lens | 50,373 | Groupama Stadium | Mikael Lesage | Match Report | |
| 12 | Sun | 2021-10-31 | 13:00 | Angers | 1.2 | 1–2 | 0.8 | Nice | 6,788 | Stade Raymond Kopa | Willy Delajod | Match Report | |
| 12 | Sun | 2021-10-31 | 15:00 | Bordeaux | 1.8 | 3–2 | 1.4 | Reims | 11,020 | Stade Matmut-Atlantique | Eric Wattellier | Match Report | |
| 12 | Sun | 2021-10-31 | 15:00 | Troyes | 1.3 | 2–2 | 1.3 | Rennes | 8,550 | Stade de l'Aube | Jeremy Stinat | Match Report | |
| 12 | Sun | 2021-10-31 | 15:00 | Montpellier | 1.2 | 2–0 | 1.0 | Nantes | 11,267 | Stade de la Mosson | Bastien Dechepy | Match Report | |
| 12 | Sun | 2021-10-31 | 15:00 | Strasbourg | 2.3 | 4–0 | 1.3 | Lorient | 24,002 | Stade de la Meinau | Florent Batta | Match Report | |
| 12 | Sun | 2021-10-31 | 17:00 | Brest | 1.3 | 2–0 | 0.4 | Monaco | 12,463 | Stade Francis-Le Blé | Johan Hamel | Match Report | |
| 12 | Sun | 2021-10-31 | 20:45 | Clermont Foot | 0.7 | 0–1 | 1.0 | Marseille | 12,240 | Stade Gabriel Montpied | Benoît Millot | Match Report | |
| 13 | Fri | 2021-11-05 | 21:00 | Lens | 3.0 | 4–0 | 0.5 | Troyes | 35,706 | Stade Bollaert-Delelis | Thomas Léonard | Match Report | |
| 13 | Sat | 2021-11-06 | 17:00 | Lille | 1.4 | 1–1 | 1.1 | Angers | 33,305 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| 13 | Sat | 2021-11-06 | 21:00 | Bordeaux | 1.4 | 2–3 | 1.5 | Paris S-G | 41,172 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| 13 | Sun | 2021-11-07 | 13:00 | Marseille | 1.3 | 0–0 | 1.2 | Metz | 61,539 | Orange Vélodrome | Jérôme Brisard | Match Report | |
| 13 | Sun | 2021-11-07 | 15:00 | Saint-Étienne | 1.3 | 3–2 | 1.1 | Clermont Foot | Stade Geoffroy-Guichard | Pierre Gaillouste | Match Report | ||
| 13 | Sun | 2021-11-07 | 15:00 | Lorient | 1.3 | 1–2 | 2.6 | Brest | 14,649 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| 13 | Sun | 2021-11-07 | 15:00 | Reims | 0.3 | 0–0 | 1.0 | Monaco | 12,080 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| 13 | Sun | 2021-11-07 | 15:00 | Nantes | 2.3 | 2–2 | 2.1 | Strasbourg | 18,853 | Stade de la Beaujoire - Louis Fonteneau | Clément Turpin | Match Report | |
| 13 | Sun | 2021-11-07 | 17:00 | Nice | 1.4 | 0–1 | 0.4 | Montpellier | 20,157 | Stade de Nice | Antony Gautier | Match Report | |
| 13 | Sun | 2021-11-07 | 20:45 | Rennes | 3.3 | 4–1 | 1.1 | Lyon | 28,222 | Roazhon Park | Benoît Bastien | Match Report | |
| 14 | Fri | 2021-11-19 | 21:00 | Monaco | 1.1 | 2–2 | 2.2 | Lille | 3,778 | Stade Louis II | Willy Delajod | Match Report | |
| 14 | Sat | 2021-11-20 | 17:00 | Paris S-G | 1.8 | 3–1 | 1.4 | Nantes | 47,777 | Parc des Princes | Jeremy Stinat | Match Report | |
| 14 | Sat | 2021-11-20 | 21:00 | Rennes | 2.9 | 2–0 | 0.7 | Montpellier | 27,003 | Roazhon Park | Mikael Lesage | Match Report | |
| 14 | Sun | 2021-11-21 | 13:00 | Brest | 1.3 | 4–0 | 1.5 | Lens | 12,462 | Stade Francis-Le Blé | Eric Wattellier | Match Report | |
| 14 | Sun | 2021-11-21 | 15:00 | Metz | 1.2 | 3–3 | 2.2 | Bordeaux | 16,077 | Stade Saint-Symphorien | Benoît Millot | Match Report | |
| 14 | Sun | 2021-11-21 | 15:00 | Angers | 1.4 | 1–0 | 0.7 | Lorient | 6,971 | Stade Raymond Kopa | Pierre Gaillouste | Match Report | |
| 14 | Sun | 2021-11-21 | 15:00 | Troyes | 1.1 | 0–1 | 1.1 | Saint-Étienne | 10,644 | Stade de l'Aube | Florent Batta | Match Report | |
| 14 | Sun | 2021-11-21 | 15:00 | Strasbourg | 1.7 | 1–1 | 0.9 | Reims | 24,439 | Stade de la Meinau | Amaury Delerue | Match Report | |
| 14 | Sun | 2021-11-21 | 17:00 | Clermont Foot | 0.7 | 1–2 | 0.6 | Nice | 11,683 | Stade Gabriel Montpied | Stéphanie Frappart | Match Report | |
| 15 | Fri | 2021-11-26 | 21:00 | Lens | 1.3 | 2–2 | 1.5 | Angers | 35,713 | Stade Bollaert-Delelis | Florent Batta | Match Report | |
| 15 | Sat | 2021-11-27 | 17:00 | Lille | 1.2 | 1–1 | 0.5 | Nantes | 30,419 | Stade Pierre-Mauroy | Johan Hamel | Match Report | |
| 15 | Sat | 2021-11-27 | 21:00 | Nice | 1.2 | 0–1 | 0.4 | Metz | 17,033 | Stade de Nice | François Letexier | Match Report | |
| 15 | Sun | 2021-11-28 | 13:00 | Saint-Étienne | 0.8 | 1–3 | 2.7 | Paris S-G | 24,586 | Stade Geoffroy-Guichard | Jérôme Brisard | Match Report | |
| 15 | Sun | 2021-11-28 | 15:00 | Reims | 0.6 | 1–0 | 0.5 | Clermont Foot | 8,420 | Stade Auguste-Delaune | Benoît Bastien | Match Report | |
| 15 | Sun | 2021-11-28 | 15:00 | Lorient | 0.8 | 0–2 | 1.3 | Rennes | 16,321 | Stade du Moustoir | Bastien Dechepy | Match Report | |
| 15 | Sun | 2021-11-28 | 15:00 | Bordeaux | 1.4 | 1–2 | 2.4 | Brest | 15,280 | Stade Matmut-Atlantique | Pierre Gaillouste | Match Report | |
| 15 | Sun | 2021-11-28 | 15:00 | Monaco | 2.1 | 1–1 | 1.0 | Strasbourg | 3,478 | Stade Louis II | Antony Gautier | Match Report | |
| 15 | Sun | 2021-11-28 | 17:00 | Montpellier | 1.2 | 0–1 | 0.9 | Lyon | 14,747 | Stade de la Mosson | Thomas Léonard | Match Report | |
| 15 | Sun | 2021-11-28 | 20:45 | Marseille | 1.6 | 1–0 | 0.1 | Troyes | Orange Vélodrome | Jérémie Pignard | Match Report | ||
| 16 | Wed | 2021-12-01 | 19:00 | Angers | 1.3 | 1–3 | 3.1 | Monaco | 8,267 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| 16 | Wed | 2021-12-01 | 19:00 | Troyes | 1.0 | 2–0 | 0.4 | Lorient | 6,506 | Stade de l'Aube | Jeremy Stinat | Match Report | |
| 16 | Wed | 2021-12-01 | 19:00 | Strasbourg | 2.8 | 5–2 | 1.1 | Bordeaux | 24,378 | Stade de la Meinau | Willy Delajod | Match Report | |
| 16 | Wed | 2021-12-01 | 19:00 | Brest | 1.5 | 1–0 | 0.6 | Saint-Étienne | 13,248 | Stade Francis-Le Blé | Mikael Lesage | Match Report | |
| 16 | Wed | 2021-12-01 | 19:00 | Metz | 1.3 | 1–3 | 1.3 | Montpellier | 13,992 | Stade Saint-Symphorien | Ruddy Buquet | Match Report | |
| 16 | Wed | 2021-12-01 | 21:00 | Rennes | 0.8 | 1–2 | 0.7 | Lille | 25,392 | Roazhon Park | Stéphanie Frappart | Match Report | |
| 16 | Wed | 2021-12-01 | 21:00 | Nantes | 0.1 | 0–1 | 1.1 | Marseille | 34,018 | Stade de la Beaujoire - Louis Fonteneau | Eric Wattellier | Match Report | |
| 16 | Wed | 2021-12-01 | 21:00 | Paris S-G | 1.9 | 0–0 | 1.0 | Nice | 47,502 | Parc des Princes | Clément Turpin | Match Report | |
| 16 | Wed | 2021-12-01 | 21:00 | Lyon | 2.6 | 1–2 | 1.2 | Reims | Groupama Stadium | Benoît Millot | Match Report | ||
| 16 | Wed | 2021-12-01 | 21:00 | Clermont Foot | 1.7 | 2–2 | 0.7 | Lens | 11,948 | Stade Gabriel Montpied | Amaury Delerue | Match Report | |
| 17 | Sat | 2021-12-04 | 17:00 | Marseille | 1.5 | 1–2 | 1.3 | Brest | 54,413 | Orange Vélodrome | Antony Gautier | Match Report | |
| 17 | Sat | 2021-12-04 | 19:00 | Lille | 1.4 | 2–1 | 0.3 | Troyes | 28,286 | Stade Pierre-Mauroy | Benoît Bastien | Match Report | |
| 17 | Sat | 2021-12-04 | 21:00 | Lens | 1.1 | 1–1 | 1.9 | Paris S-G | 36,685 | Stade Bollaert-Delelis | François Letexier | Match Report | |
| 17 | Sun | 2021-12-05 | 13:00 | Saint-Étienne | 0.5 | 0–5 | 2.6 | Rennes | 11,257 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| 17 | Sun | 2021-12-05 | 15:00 | Montpellier | 0.9 | 1–0 | 0.4 | Clermont Foot | 9,643 | Stade de la Mosson | Florent Batta | Match Report | |
| 17 | Sun | 2021-12-05 | 15:00 | Monaco | 1.6 | 4–0 | 0.6 | Metz | 4,923 | Stade Louis II | Bastien Dechepy | Match Report | |
| 17 | Sun | 2021-12-05 | 15:00 | Reims | 1.2 | 1–2 | 2.2 | Angers | 8,238 | Stade Auguste-Delaune | Johan Hamel | Match Report | |
| 17 | Sun | 2021-12-05 | 15:00 | Lorient | 0.9 | 0–1 | 0.2 | Nantes | 16,025 | Stade du Moustoir | Ruddy Buquet | Match Report | |
| 17 | Sun | 2021-12-05 | 17:00 | Nice | 1.3 | 0–3 | 2.6 | Strasbourg | 16,220 | Stade de Nice | Jérémie Pignard | Match Report | |
| 17 | Sun | 2021-12-05 | 20:45 | Bordeaux | 2.6 | 2–2 | 2.3 | Lyon | 25,210 | Stade Matmut-Atlantique | Jérôme Brisard | Match Report | |
| 18 | Fri | 2021-12-10 | 21:00 | Nantes | 1.4 | 3–2 | 1.0 | Lens | 21,890 | Stade de la Beaujoire - Louis Fonteneau | Stéphanie Frappart | Match Report | |
| 18 | Sat | 2021-12-11 | 17:00 | Brest | 0.9 | 0–4 | 1.6 | Montpellier | 13,111 | Stade Francis-Le Blé | Benoît Millot | Match Report | |
| 18 | Sat | 2021-12-11 | 21:00 | Reims | 2.3 | 2–0 | 0.1 | Saint-Étienne | 12,019 | Stade Auguste-Delaune | Pierre Gaillouste | Match Report | |
| 18 | Sun | 2021-12-12 | 13:00 | Lille | 1.5 | 0–0 | 0.4 | Lyon | 40,248 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| 18 | Sun | 2021-12-12 | 15:00 | Angers | 1.7 | 0–1 | 1.7 | Clermont Foot | 8,149 | Stade Raymond Kopa | Jeremy Stinat | Match Report | |
| 18 | Sun | 2021-12-12 | 15:00 | Rennes | 1.6 | 1–2 | 1.4 | Nice | 27,892 | Roazhon Park | Willy Delajod | Match Report | |
| 18 | Sun | 2021-12-12 | 15:00 | Troyes | 1.5 | 1–2 | 1.3 | Bordeaux | 7,950 | Stade de l'Aube | Romain Lissorgue | Match Report | |
| 18 | Sun | 2021-12-12 | 15:00 | Metz | 1.1 | 4–1 | 1.4 | Lorient | 14,037 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| 18 | Sun | 2021-12-12 | 17:00 | Strasbourg | 1.9 | 0–2 | 0.7 | Marseille | 26,028 | Stade de la Meinau | Mikael Lesage | Match Report | |
| 18 | Sun | 2021-12-12 | 20:45 | Paris S-G | 1.6 | 2–0 | 0.7 | Monaco | 41,154 | Parc des Princes | Benoît Bastien | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Lyon | 2.3 | 1–1 | 0.5 | Metz | 34,867 | Groupama Stadium | Pierre Gaillouste | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Saint-Étienne | 1.0 | 0–1 | 0.9 | Nantes | 23,681 | Stade Geoffroy-Guichard | Clément Turpin | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Lorient | 1.6 | 1–1 | 1.8 | Paris S-G | 16,603 | Stade du Moustoir | Jérémie Pignard | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Nice | 0.9 | 2–1 | 1.0 | Lens | 22,065 | Stade de Nice | Jérôme Brisard | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Monaco | 1.8 | 2–1 | 1.4 | Rennes | 5,354 | Stade Louis II | Ruddy Buquet | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Marseille | 1.4 | 1–1 | 0.8 | Reims | 55,908 | Orange Vélodrome | François Letexier | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Montpellier | 1.1 | 4–1 | 0.6 | Angers | 10,990 | Stade de la Mosson | Hugo Miguel | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Troyes | 1.2 | 1–1 | 0.6 | Brest | 6,872 | Stade de l'Aube | Johan Hamel | Match Report | |
| 19 | Wed | 2021-12-22 | 21:00 | Bordeaux | 1.2 | 2–3 | 1.3 | Lille | 39,967 | Stade Matmut-Atlantique | Mikael Lesage | Match Report | |
| 20 | Fri | 2022-01-07 | 21:00 | Bordeaux | 0.5 | 0–1 | 2.4 | Marseille | Stade Matmut-Atlantique | Eric Wattellier | Match Report | ||
| 20 | Sat | 2022-01-08 | 21:00 | Lens | 0.8 | 1–0 | 0.5 | Rennes | 5,000 | Stade Bollaert-Delelis | Benoît Bastien | Match Report | |
| 20 | Sun | 2022-01-09 | 13:00 | Brest | 1.6 | 0–3 | 1.2 | Nice | 5,102 | Stade Francis-Le Blé | Stéphanie Frappart | Match Report | |
| 20 | Sun | 2022-01-09 | 15:00 | Metz | 0.3 | 0–2 | 2.6 | Strasbourg | 5,000 | Stade Saint-Symphorien | Antony Gautier | Match Report | |
| 20 | Sun | 2022-01-09 | 15:00 | Clermont Foot | 0.9 | 0–0 | 0.9 | Reims | 4,923 | Stade Gabriel Montpied | Romain Lissorgue | Match Report | |
| 20 | Sun | 2022-01-09 | 17:05 | Nantes | 0.4 | 0–0 | 0.8 | Monaco | 4,133 | Stade de la Beaujoire - Louis Fonteneau | Thomas Léonard | Match Report | |
| 20 | Sun | 2022-01-09 | 20:45 | Lyon | 1.0 | 1–1 | 1.0 | Paris S-G | 4,977 | Groupama Stadium | François Letexier | Match Report | |
| 21 | Fri | 2022-01-14 | 21:00 | Nice | 1.7 | 2–1 | 0.4 | Nantes | 5,000 | Stade de Nice | Ruddy Buquet | Match Report | |
| 21 | Sat | 2022-01-15 | 17:00 | Saint-Étienne | 1.3 | 1–2 | 0.9 | Lens | 5,000 | Stade Geoffroy-Guichard | François Letexier | Match Report | |
| 21 | Sat | 2022-01-15 | 21:00 | Paris S-G | 2.0 | 2–0 | 1.0 | Brest | 4,925 | Parc des Princes | Mikael Lesage | Match Report | |
| 21 | Sun | 2022-01-16 | 13:00 | Rennes | 3.1 | 6–0 | 0.3 | Bordeaux | 4,951 | Roazhon Park | Bastien Dechepy | Match Report | |
| 21 | Sun | 2022-01-16 | 15:00 | Reims | 0.6 | 0–1 | 0.8 | Metz | 3,923 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| 21 | Sun | 2022-01-16 | 15:00 | Monaco | 3.6 | 4–0 | 0.4 | Clermont Foot | 2,633 | Stade Louis II | Jeremy Stinat | Match Report | |
| 21 | Sun | 2022-01-16 | 15:00 | Lorient | 0.5 | 0–0 | 0.4 | Angers | 4,387 | Stade du Moustoir | Johan Hamel | Match Report | |
| 21 | Sun | 2022-01-16 | 15:00 | Strasbourg | 1.6 | 3–1 | 0.6 | Montpellier | 5,217 | Stade de la Meinau | Pierre Gaillouste | Match Report | |
| 21 | Sun | 2022-01-16 | 17:05 | Troyes | 0.4 | 0–1 | 2.8 | Lyon | 4,224 | Stade de l'Aube | Jérôme Brisard | Match Report | |
| 21 | Sun | 2022-01-16 | 20:45 | Marseille | 1.7 | 1–1 | 0.7 | Lille | 5,034 | Orange Vélodrome | Amaury Delerue | Match Report | |
| 19 | Wed | 2022-01-19 | 19:00 | Clermont Foot | 0.6 | 0–2 | 1.5 | Strasbourg | 4,219 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| 20 | Wed | 2022-01-19 | 19:00 | Montpellier | 0.9 | 0–1 | 0.8 | Troyes | 4,943 | Stade de la Mosson | Jeremy Stinat | Match Report | |
| 20 | Wed | 2022-01-19 | 19:00 | Lille | 1.7 | 3–1 | 1.1 | Lorient | 4,834 | Stade Pierre-Mauroy | Florent Batta | Match Report | |
| 22 | Fri | 2022-01-21 | 21:00 | Lyon | 1.8 | 1–0 | 0.3 | Saint-Étienne | 5,000 | Groupama Stadium | Antony Gautier | Match Report | |
| 22 | Sat | 2022-01-22 | 17:00 | Brest | 1.2 | 2–0 | 1.2 | Lille | 4,358 | Stade Francis-Le Blé | Jérôme Brisard | Match Report | |
| 22 | Sat | 2022-01-22 | 21:00 | Lens | 0.8 | 0–2 | 1.3 | Marseille | 5,000 | Stade Bollaert-Delelis | Stéphanie Frappart | Match Report | |
| 22 | Sun | 2022-01-23 | 13:00 | Metz | 0.4 | 0–2 | 1.9 | Nice | 5,000 | Stade Saint-Symphorien | Amaury Delerue | Match Report | |
| 22 | Sun | 2022-01-23 | 15:00 | Clermont Foot | 1.1 | 2–1 | 1.7 | Rennes | 4,535 | Stade Gabriel Montpied | Thomas Léonard | Match Report | |
| 22 | Sun | 2022-01-23 | 15:00 | Nantes | 0.9 | 4–2 | 2.1 | Lorient | 4,275 | Stade de la Beaujoire - Louis Fonteneau | Pierre Gaillouste | Match Report | |
| 22 | Sun | 2022-01-23 | 15:00 | Angers | 2.4 | 2–1 | 1.7 | Troyes | 5,000 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| 22 | Sun | 2022-01-23 | 15:00 | Bordeaux | 1.9 | 4–3 | 1.9 | Strasbourg | 3,308 | Stade Matmut-Atlantique | Mikael Lesage | Match Report | |
| 22 | Sun | 2022-01-23 | 17:05 | Montpellier | 1.7 | 3–2 | 1.2 | Monaco | 5,000 | Stade de la Mosson | Jérémie Pignard | Match Report | |
| 22 | Sun | 2022-01-23 | 20:45 | Paris S-G | 2.3 | 4–0 | 0.5 | Reims | 5,000 | Parc des Princes | Eric Wattellier | Match Report | |
| 20 | Wed | 2022-01-26 | 19:00 | Angers | 0.4 | 0–1 | 0.4 | Saint-Étienne | Stade Raymond Kopa | Clément Turpin | Match Report | ||
| 14 | Tue | 2022-02-01 | 21:00 | Lyon | 1.2 | 2–1 | 0.4 | Marseille | Groupama Stadium | Benoît Bastien | Match Report | ||
| 23 | Fri | 2022-02-04 | 21:00 | Marseille | 2.6 | 5–2 | 0.4 | Angers | 60,000 | Orange Vélodrome | Jeremy Stinat | Match Report | |
| 23 | Sat | 2022-02-05 | 17:00 | Saint-Étienne | 2.0 | 3–1 | 0.6 | Montpellier | 20,000 | Stade Geoffroy-Guichard | Thomas Léonard | Match Report | |
| 23 | Sat | 2022-02-05 | 21:00 | Monaco | 2.3 | 2–0 | 1.3 | Lyon | 6,550 | Stade Louis II | Ruddy Buquet | Match Report | |
| 23 | Sun | 2022-02-06 | 13:00 | Lorient | 1.5 | 2–0 | 0.4 | Lens | 10,687 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| 23 | Sun | 2022-02-06 | 15:00 | Reims | 2.0 | 5–0 | 0.1 | Bordeaux | 8,858 | Stade Auguste-Delaune | Antony Gautier | Match Report | |
| 23 | Sun | 2022-02-06 | 15:00 | Nice | 1.0 | 0–1 | 1.5 | Clermont Foot | 18,022 | Stade de Nice | Jérôme Brisard | Match Report | |
| 23 | Sun | 2022-02-06 | 15:00 | Troyes | 0.6 | 0–0 | 0.5 | Metz | 7,227 | Stade de l'Aube | Pierre Gaillouste | Match Report | |
| 23 | Sun | 2022-02-06 | 15:00 | Strasbourg | 1.4 | 1–0 | 0.4 | Nantes | 22,240 | Stade de la Meinau | Amaury Delerue | Match Report | |
| 23 | Sun | 2022-02-06 | 17:00 | Rennes | 2.1 | 2–0 | 0.4 | Brest | 25,409 | Roazhon Park | Johan Hamel | Match Report | |
| 23 | Sun | 2022-02-06 | 20:45 | Lille | 1.0 | 1–5 | 3.9 | Paris S-G | 48,437 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| 24 | Fri | 2022-02-11 | 21:00 | Paris S-G | 0.9 | 1–0 | 0.8 | Rennes | 47,000 | Parc des Princes | Benoît Bastien | Match Report | |
| 24 | Sat | 2022-02-12 | 17:00 | Montpellier | 1.0 | 0–1 | 1.3 | Lille | 11,784 | Stade de la Mosson | Stéphanie Frappart | Match Report | |
| 24 | Sat | 2022-02-12 | 21:00 | Lyon | 2.4 | 2–0 | 0.1 | Nice | 41,974 | Groupama Stadium | Benoît Millot | Match Report | |
| 24 | Sun | 2022-02-13 | 13:00 | Monaco | 1.2 | 0–0 | 0.1 | Lorient | 3,963 | Stade Louis II | Bastien Dechepy | Match Report | |
| 24 | Sun | 2022-02-13 | 15:00 | Angers | 0.5 | 0–1 | 0.3 | Strasbourg | 6,521 | Stade Raymond Kopa | Pierre Gaillouste | Match Report | |
| 24 | Sun | 2022-02-13 | 15:00 | Brest | 2.7 | 5–1 | 0.5 | Troyes | 10,600 | Stade Francis-Le Blé | Florent Batta | Match Report | |
| 24 | Sun | 2022-02-13 | 15:00 | Nantes | 0.5 | 1–0 | 0.4 | Reims | 14,304 | Stade de la Beaujoire - Louis Fonteneau | Johan Hamel | Match Report | |
| 24 | Sun | 2022-02-13 | 15:00 | Clermont Foot | 0.9 | 1–2 | 0.7 | Saint-Étienne | 12,131 | Stade Gabriel Montpied | Ruddy Buquet | Match Report | |
| 24 | Sun | 2022-02-13 | 17:05 | Lens | 2.1 | 3–2 | 0.9 | Bordeaux | 32,662 | Stade Bollaert-Delelis | François Letexier | Match Report | |
| 24 | Sun | 2022-02-13 | 20:45 | Metz | 0.9 | 1–2 | 1.2 | Marseille | 25,482 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| 25 | Fri | 2022-02-18 | 21:00 | Lille | 1.1 | 0–0 | 0.4 | Metz | 30,384 | Stade Pierre-Mauroy | Bastien Dechepy | Match Report | |
| 25 | Sat | 2022-02-19 | 17:00 | Lens | 1.2 | 1–1 | 1.4 | Lyon | 36,624 | Stade Bollaert-Delelis | Jérôme Brisard | Match Report | |
| 25 | Sat | 2022-02-19 | 21:00 | Nantes | 2.4 | 3–1 | 3.4 | Paris S-G | 35,500 | Stade de la Beaujoire - Louis Fonteneau | Mikael Lesage | Match Report | |
| 25 | Sun | 2022-02-20 | 13:00 | Nice | 0.8 | 1–0 | 0.8 | Angers | 18,257 | Stade de Nice | Romain Lissorgue | Match Report | |
| 25 | Sun | 2022-02-20 | 15:00 | Saint-Étienne | 1.1 | 2–2 | 0.8 | Strasbourg | 24,897 | Stade Geoffroy-Guichard | Antony Gautier | Match Report | |
| 25 | Sun | 2022-02-20 | 15:00 | Reims | 0.7 | 1–1 | 1.7 | Brest | 9,307 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| 25 | Sun | 2022-02-20 | 15:00 | Rennes | 2.8 | 4–1 | 0.6 | Troyes | 22,967 | Roazhon Park | Clément Turpin | Match Report | |
| 25 | Sun | 2022-02-20 | 15:00 | Lorient | 0.8 | 0–1 | 0.4 | Montpellier | 10,135 | Stade du Moustoir | Jeremy Stinat | Match Report | |
| 25 | Sun | 2022-02-20 | 17:05 | Bordeaux | 0.5 | 1–1 | 1.8 | Monaco | 29,557 | Stade Matmut-Atlantique | Jérémie Pignard | Match Report | |
| 25 | Sun | 2022-02-20 | 20:45 | Marseille | 1.2 | 0–2 | 0.8 | Clermont Foot | 53,840 | Orange Vélodrome | Willy Delajod | Match Report | |
| 26 | Fri | 2022-02-25 | 21:00 | Montpellier | 1.2 | 2–4 | 1.9 | Rennes | 10,000 | Stade de la Mosson | Amaury Delerue | Match Report | |
| 26 | Sat | 2022-02-26 | 17:00 | Strasbourg | 0.8 | 0–0 | 0.2 | Nice | 25,150 | Stade de la Meinau | Stéphanie Frappart | Match Report | |
| 26 | Sat | 2022-02-26 | 21:00 | Paris S-G | 2.1 | 3–1 | 0.8 | Saint-Étienne | 45,000 | Parc des Princes | Pierre Gaillouste | Match Report | |
| 26 | Sun | 2022-02-27 | 13:00 | Monaco | 1.2 | 1–2 | 1.4 | Reims | 3,982 | Stade Louis II | Benoît Millot | Match Report | |
| 26 | Sun | 2022-02-27 | 15:00 | Angers | 0.6 | 1–2 | 0.6 | Lens | 9,499 | Stade Raymond Kopa | Thomas Léonard | Match Report | |
| 26 | Sun | 2022-02-27 | 15:00 | Metz | 0.5 | 0–0 | 0.6 | Nantes | 15,851 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| 26 | Sun | 2022-02-27 | 15:00 | Clermont Foot | 0.7 | 1–1 | 0.8 | Bordeaux | 12,032 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| 26 | Sun | 2022-02-27 | 15:00 | Brest | 0.2 | 0–1 | 2.5 | Lorient | 14,050 | Stade Francis-Le Blé | Benoît Bastien | Match Report | |
| 26 | Sun | 2022-02-27 | 17:05 | Troyes | 1.5 | 1–1 | 1.2 | Marseille | 16,871 | Stade de l'Aube | François Letexier | Match Report | |
| 26 | Sun | 2022-02-27 | 20:45 | Lyon | 1.4 | 0–1 | 0.7 | Lille | 42,647 | Groupama Stadium | Clément Turpin | Match Report | |
| 27 | Fri | 2022-03-04 | 21:00 | Lorient | 1.5 | 1–4 | 2.1 | Lyon | 13,497 | Stade du Moustoir | Romain Lissorgue | Match Report | |
| 27 | Sat | 2022-03-05 | 17:00 | Lens | 2.0 | 0–1 | 0.5 | Brest | 36,305 | Stade Bollaert-Delelis | Johan Hamel | Match Report | |
| 27 | Sat | 2022-03-05 | 21:00 | Nice | 0.9 | 1–0 | 0.4 | Paris S-G | 31,949 | Stade de Nice | Willy Delajod | Match Report | |
| 27 | Sun | 2022-03-06 | 13:00 | Saint-Étienne | 1.4 | 1–0 | 0.5 | Metz | 35,706 | Stade Geoffroy-Guichard | Jeremy Stinat | Match Report | |
| 27 | Sun | 2022-03-06 | 15:00 | Nantes | 1.7 | 2–0 | 0.2 | Montpellier | 21,589 | Stade de la Beaujoire - Louis Fonteneau | Hakim Ben El Hadj Salem | Match Report | |
| 27 | Sun | 2022-03-06 | 15:00 | Reims | 0.9 | 1–1 | 0.7 | Strasbourg | 10,405 | Stade Auguste-Delaune | Jérémie Pignard | Match Report | |
| 27 | Sun | 2022-03-06 | 15:00 | Rennes | 1.6 | 2–0 | 0.6 | Angers | 27,693 | Roazhon Park | Benoît Millot | Match Report | |
| 27 | Sun | 2022-03-06 | 15:00 | Bordeaux | 0.7 | 0–2 | 2.2 | Troyes | 20,287 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| 27 | Sun | 2022-03-06 | 17:05 | Lille | 2.0 | 4–0 | 0.9 | Clermont Foot | 33,515 | Stade Pierre-Mauroy | Thomas Léonard | Match Report | |
| 27 | Sun | 2022-03-06 | 20:45 | Marseille | 0.7 | 0–1 | 0.8 | Monaco | 56,510 | Orange Vélodrome | Antony Gautier | Match Report | |
| 28 | Fri | 2022-03-11 | 21:00 | Lille | 1.0 | 0–0 | 0.4 | Saint-Étienne | 40,146 | Stade Pierre-Mauroy | Florent Batta | Match Report | |
| 28 | Sat | 2022-03-12 | 17:00 | Montpellier | 2.9 | 0–0 | 0.8 | Nice | 11,658 | Stade de la Mosson | Clément Turpin | Match Report | |
| 28 | Sat | 2022-03-12 | 21:00 | Troyes | 1.6 | 1–0 | 0.4 | Nantes | 7,400 | Stade de l'Aube | Stéphanie Frappart | Match Report | |
| 28 | Sun | 2022-03-13 | 13:00 | Paris S-G | 1.2 | 3–0 | 0.8 | Bordeaux | 44,000 | Parc des Princes | François Letexier | Match Report | |
| 28 | Sun | 2022-03-13 | 15:00 | Strasbourg | 0.8 | 1–0 | 0.8 | Monaco | 25,231 | Stade de la Meinau | Eric Wattellier | Match Report | |
| 28 | Sun | 2022-03-13 | 15:00 | Clermont Foot | 1.0 | 0–2 | 1.0 | Lorient | 11,359 | Stade Gabriel Montpied | Bastien Dechepy | Match Report | |
| 28 | Sun | 2022-03-13 | 15:00 | Metz | 0.7 | 0–0 | 0.5 | Lens | 15,687 | Stade Saint-Symphorien | Amaury Delerue | Match Report | |
| 28 | Sun | 2022-03-13 | 15:00 | Angers | 2.1 | 0–1 | 1.5 | Reims | 5,960 | Stade Raymond Kopa | Mikael Lesage | Match Report | |
| 28 | Sun | 2022-03-13 | 17:05 | Lyon | 1.3 | 2–4 | 1.5 | Rennes | 46,597 | Groupama Stadium | Antony Gautier | Match Report | |
| 28 | Sun | 2022-03-13 | 20:45 | Brest | 0.6 | 1–4 | 2.2 | Marseille | 14,611 | Stade Francis-Le Blé | Ruddy Buquet | Match Report | |
| 29 | Fri | 2022-03-18 | 21:00 | Saint-Étienne | 1.3 | 1–1 | 1.0 | Troyes | 32,193 | Stade Geoffroy-Guichard | Romain Lissorgue | Match Report | |
| 29 | Sat | 2022-03-19 | 17:00 | Lens | 1.2 | 3–1 | 1.4 | Clermont Foot | 36,182 | Stade Bollaert-Delelis | Jeremy Stinat | Match Report | |
| 29 | Sat | 2022-03-19 | 21:00 | Nantes | 0.8 | 0–1 | 1.1 | Lille | 25,977 | Stade de la Beaujoire - Louis Fonteneau | Pierre Gaillouste | Match Report | |
| 29 | Sun | 2022-03-20 | 13:00 | Monaco | 1.9 | 3–0 | 1.0 | Paris S-G | 16,642 | Stade Louis II | Benoît Bastien | Match Report | |
| 29 | Sun | 2022-03-20 | 15:00 | Angers | 1.8 | 1–0 | 1.2 | Brest | 7,734 | Stade Raymond Kopa | Jérémie Pignard | Match Report | |
| 29 | Sun | 2022-03-20 | 15:00 | Rennes | 3.5 | 6–1 | 0.7 | Metz | 27,966 | Roazhon Park | Willy Delajod | Match Report | |
| 29 | Sun | 2022-03-20 | 15:00 | Bordeaux | 3.5 | 0–2 | 0.4 | Montpellier | 15,000 | Stade Matmut-Atlantique | Thomas Léonard | Match Report | |
| 29 | Sun | 2022-03-20 | 15:00 | Lorient | 0.3 | 0–0 | 1.1 | Strasbourg | 9,806 | Stade du Moustoir | Benoît Millot | Match Report | |
| 29 | Sun | 2022-03-20 | 17:05 | Reims | 0.5 | 0–0 | 1.5 | Lyon | 14,091 | Stade Auguste-Delaune | Johan Hamel | Match Report | |
| 29 | Sun | 2022-03-20 | 20:45 | Marseille | 1.5 | 2–1 | 1.4 | Nice | 64,722 | Orange Vélodrome | Jérôme Brisard | Match Report | |
| 30 | Sat | 2022-04-02 | 17:00 | Nice | 0.8 | 1–1 | 1.1 | Rennes | 24,086 | Stade de Nice | Benoît Bastien | Match Report | |
| 30 | Sat | 2022-04-02 | 19:00 | Lille | 2.7 | 0–0 | 0.0 | Bordeaux | 36,351 | Stade Pierre-Mauroy | Bastien Dechepy | Match Report | |
| 30 | Sun | 2022-04-03 | 13:00 | Strasbourg | 2.5 | 1–0 | 0.9 | Lens | 26,005 | Stade de la Meinau | François Letexier | Match Report | |
| 30 | Sun | 2022-04-03 | 15:00 | Metz | 0.9 | 1–2 | 1.5 | Monaco | 19,812 | Stade Saint-Symphorien | Jérôme Brisard | Match Report | |
| 30 | Sun | 2022-04-03 | 15:00 | Saint-Étienne | 0.2 | 2–4 | 3.9 | Marseille | 41,278 | Stade Geoffroy-Guichard | Clément Turpin | Match Report | |
| 30 | Sun | 2022-04-03 | 15:00 | Troyes | 1.1 | 1–0 | 0.6 | Reims | 9,482 | Stade de l'Aube | Ruddy Buquet | Match Report | |
| 30 | Sun | 2022-04-03 | 15:00 | Montpellier | 1.4 | 1–2 | 0.7 | Brest | 10,929 | Stade de la Mosson | Florent Batta | Match Report | |
| 30 | Sun | 2022-04-03 | 15:00 | Clermont Foot | 0.9 | 2–3 | 2.0 | Nantes | 11,785 | Stade Gabriel Montpied | Mikael Lesage | Match Report | |
| 30 | Sun | 2022-04-03 | 17:05 | Lyon | 1.7 | 3–2 | 1.8 | Angers | 34,376 | Groupama Stadium | Eric Wattellier | Match Report | |
| 30 | Sun | 2022-04-03 | 20:45 | Paris S-G | 1.9 | 5–1 | 0.6 | Lorient | 40,000 | Parc des Princes | Hakim Ben El Hadj Salem | Match Report | |
| 31 | Fri | 2022-04-08 | 21:00 | Lorient | 3.7 | 6–2 | 0.9 | Saint-Étienne | 15,407 | Stade du Moustoir | Ruddy Buquet | Match Report | |
| 31 | Sat | 2022-04-09 | 17:00 | Reims | 2.6 | 2–3 | 1.5 | Rennes | 10,243 | Stade Auguste-Delaune | Romain Lissorgue | Match Report | |
| 31 | Sat | 2022-04-09 | 21:00 | Clermont Foot | 1.4 | 1–6 | 3.7 | Paris S-G | 12,264 | Stade Gabriel Montpied | Eric Wattellier | Match Report | |
| 31 | Sun | 2022-04-10 | 13:00 | Bordeaux | 2.0 | 3–1 | 0.5 | Metz | 21,652 | Stade Matmut-Atlantique | Jérémie Pignard | Match Report | |
| 31 | Sun | 2022-04-10 | 15:00 | Monaco | 0.4 | 2–1 | 1.0 | Troyes | 4,786 | Stade Louis II | Mikael Lesage | Match Report | |
| 31 | Sun | 2022-04-10 | 15:00 | Angers | 0.5 | 1–1 | 1.2 | Lille | 9,286 | Stade Raymond Kopa | Thomas Léonard | Match Report | |
| 31 | Sun | 2022-04-10 | 15:00 | Brest | 1.1 | 1–1 | 0.7 | Nantes | 13,145 | Stade Francis-Le Blé | Johan Hamel | Match Report | |
| 31 | Sun | 2022-04-10 | 17:05 | Lens | 0.9 | 3–0 | 1.4 | Nice | 36,668 | Stade Bollaert-Delelis | Willy Delajod | Match Report | |
| 31 | Sun | 2022-04-10 | 19:00 | Strasbourg | 1.0 | 1–1 | 1.5 | Lyon | 26,073 | Stade de la Meinau | Clément Turpin | Match Report | |
| 31 | Sun | 2022-04-10 | 21:00 | Marseille | 3.4 | 2–0 | 0.4 | Montpellier | 51,131 | Orange Vélodrome | Jeremy Stinat | Match Report | |
| 32 | Fri | 2022-04-15 | 21:00 | Rennes | 2.2 | 2–3 | 2.7 | Monaco | 28,336 | Roazhon Park | Stéphanie Frappart | Match Report | |
| 32 | Sat | 2022-04-16 | 17:00 | Saint-Étienne | 1.0 | 2–1 | 0.4 | Brest | 27,227 | Stade Geoffroy-Guichard | Eric Wattellier | Match Report | |
| 32 | Sat | 2022-04-16 | 21:00 | Lille | 0.8 | 1–2 | 1.2 | Lens | 48,169 | Stade Pierre-Mauroy | Jérôme Brisard | Match Report | |
| 32 | Sun | 2022-04-17 | 13:00 | Nice | 2.2 | 2–1 | 0.2 | Lorient | 17,212 | Stade de Nice | Amaury Delerue | Match Report | |
| 32 | Sun | 2022-04-17 | 15:00 | Nantes | 2.9 | 1–1 | 0.8 | Angers | 25,102 | Stade de la Beaujoire - Louis Fonteneau | Bastien Dechepy | Match Report | |
| 32 | Sun | 2022-04-17 | 15:00 | Metz | 0.3 | 1–1 | 2.4 | Clermont Foot | 14,335 | Stade Saint-Symphorien | Pierre Gaillouste | Match Report | |
| 32 | Sun | 2022-04-17 | 15:00 | Montpellier | 1.5 | 0–0 | 1.0 | Reims | 10,170 | Stade de la Mosson | Antony Gautier | Match Report | |
| 32 | Sun | 2022-04-17 | 15:00 | Troyes | 1.7 | 1–1 | 1.7 | Strasbourg | 10,000 | Stade de l'Aube | Benoît Millot | Match Report | |
| 32 | Sun | 2022-04-17 | 17:05 | Lyon | 1.7 | 6–1 | 2.2 | Bordeaux | 38,713 | Groupama Stadium | Florent Batta | Match Report | |
| 32 | Sun | 2022-04-17 | 20:45 | Paris S-G | 1.5 | 2–1 | 0.9 | Marseille | 46,000 | Parc des Princes | François Letexier | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Reims | 1.0 | 2–1 | 1.2 | Lille | 10,910 | Stade Auguste-Delaune | Hakim Ben El Hadj Salem | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Monaco | 1.7 | 1–0 | 0.7 | Nice | 10,247 | Stade Louis II | Benoît Millot | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Bordeaux | 0.9 | 2–2 | 0.9 | Saint-Étienne | 38,515 | Stade Matmut-Atlantique | Benoît Bastien | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Lorient | 1.8 | 1–0 | 1.4 | Metz | 13,544 | Stade du Moustoir | Mikael Lesage | Match Report | |
| 33 | Wed | 2022-04-20 | 19:00 | Troyes | 1.1 | 0–1 | 0.2 | Clermont Foot | 7,800 | Stade de l'Aube | Jérémie Pignard | Match Report | |
| 33 | Wed | 2022-04-20 | 21:00 | Angers | 0.8 | 0–3 | 1.7 | Paris S-G | 13,000 | Stade Raymond Kopa | Johan Hamel | Match Report | |
| 33 | Wed | 2022-04-20 | 21:00 | Strasbourg | 2.4 | 2–1 | 0.7 | Rennes | 25,148 | Stade de la Meinau | Willy Delajod | Match Report | |
| 33 | Wed | 2022-04-20 | 21:00 | Lens | 1.4 | 2–0 | 0.7 | Montpellier | 36,250 | Stade Bollaert-Delelis | Romain Lissorgue | Match Report | |
| 33 | Wed | 2022-04-20 | 21:00 | Brest | 1.2 | 2–1 | 2.7 | Lyon | 14,028 | Stade Francis-Le Blé | Jeremy Stinat | Match Report | |
| 33 | Wed | 2022-04-20 | 21:00 | Marseille | 3.3 | 3–2 | 0.6 | Nantes | 55,890 | Orange Vélodrome | Ruddy Buquet | Match Report | |
| 34 | Sat | 2022-04-23 | 17:00 | Lyon | 3.6 | 5–2 | 2.0 | Montpellier | 46,608 | Groupama Stadium | François Letexier | Match Report | |
| 34 | Sat | 2022-04-23 | 19:00 | Saint-Étienne | 1.1 | 1–4 | 3.3 | Monaco | 30,018 | Stade Geoffroy-Guichard | Bastien Dechepy | Match Report | |
| 34 | Sat | 2022-04-23 | 21:00 | Paris S-G | 2.0 | 1–1 | 0.8 | Lens | 47,000 | Parc des Princes | Amaury Delerue | Match Report | |
| 34 | Sun | 2022-04-24 | 13:00 | Rennes | 1.6 | 5–0 | 0.6 | Lorient | 28,324 | Roazhon Park | Benoît Millot | Match Report | |
| 34 | Sun | 2022-04-24 | 15:00 | Metz | 0.4 | 0–1 | 1.7 | Brest | 19,874 | Stade Saint-Symphorien | Florent Batta | Match Report | |
| 34 | Sun | 2022-04-24 | 15:00 | Nantes | 2.5 | 5–3 | 2.8 | Bordeaux | 30,000 | Stade de la Beaujoire - Louis Fonteneau | Clément Turpin | Match Report | |
| 34 | Sun | 2022-04-24 | 15:00 | Nice | 2.0 | 1–0 | 0.4 | Troyes | 17,065 | Stade de Nice | Hakim Ben El Hadj Salem | Match Report | |
| 34 | Sun | 2022-04-24 | 15:00 | Clermont Foot | 2.1 | 2–2 | 1.3 | Angers | 11,531 | Stade Gabriel Montpied | Stéphanie Frappart | Match Report | |
| 34 | Sun | 2022-04-24 | 17:05 | Lille | 0.5 | 1–0 | 1.0 | Strasbourg | 30,211 | Stade Pierre-Mauroy | Jérémie Pignard | Match Report | |
| 34 | Sun | 2022-04-24 | 20:45 | Reims | 0.6 | 0–1 | 0.6 | Marseille | 20,835 | Stade Auguste-Delaune | Jérôme Brisard | Match Report | |
| 35 | Fri | 2022-04-29 | 21:00 | Strasbourg | 1.7 | 3–3 | 2.3 | Paris S-G | 26,052 | Stade de la Meinau | Ruddy Buquet | Match Report | |
| 35 | Sat | 2022-04-30 | 17:00 | Lens | 2.3 | 2–2 | 1.4 | Nantes | 36,727 | Stade Bollaert-Delelis | Thomas Léonard | Match Report | |
| 35 | Sat | 2022-04-30 | 21:00 | Rennes | 1.6 | 2–0 | 0.7 | Saint-Étienne | 27,390 | Roazhon Park | Jeremy Stinat | Match Report | |
| 35 | Sun | 2022-05-01 | 13:00 | Troyes | 2.9 | 3–0 | 0.5 | Lille | 10,497 | Stade de l'Aube | Willy Delajod | Match Report | |
| 35 | Sun | 2022-05-01 | 15:00 | Brest | 1.3 | 2–0 | 1.1 | Clermont Foot | 10,592 | Stade Francis-Le Blé | Romain Lissorgue | Match Report | |
| 35 | Sun | 2022-05-01 | 15:00 | Monaco | 2.6 | 2–0 | 0.7 | Angers | 4,616 | Stade Louis II | Hakim Ben El Hadj Salem | Match Report | |
| 35 | Sun | 2022-05-01 | 15:00 | Montpellier | 2.1 | 2–2 | 1.1 | Metz | 10,446 | Stade de la Mosson | Clément Turpin | Match Report | |
| 35 | Sun | 2022-05-01 | 15:00 | Lorient | 1.9 | 1–2 | 1.6 | Reims | 12,216 | Stade du Moustoir | Pierre Gaillouste | Match Report | |
| 35 | Sun | 2022-05-01 | 17:05 | Bordeaux | 0.3 | 0–1 | 2.7 | Nice | 23,552 | Stade Matmut-Atlantique | Johan Hamel | Match Report | |
| 35 | Sun | 2022-05-01 | 20:45 | Marseille | 1.4 | 0–3 | 2.4 | Lyon | 68,784 | Orange Vélodrome | Antony Gautier | Match Report | |
| 36 | Fri | 2022-05-06 | 21:00 | Lille | 1.0 | 1–2 | 0.3 | Monaco | 39,088 | Stade Pierre-Mauroy | François Letexier | Match Report | |
| 36 | Sat | 2022-05-07 | 17:00 | Brest | 0.4 | 0–1 | 2.2 | Strasbourg | 12,093 | Stade Francis-Le Blé | Mikael Lesage | Match Report | |
| 36 | Sun | 2022-05-08 | 13:00 | Metz | 2.0 | 3–2 | 2.0 | Lyon | 20,405 | Stade Saint-Symphorien | Eric Wattellier | Match Report | |
| 36 | Sun | 2022-05-08 | 15:00 | Clermont Foot | 2.2 | 2–1 | 1.2 | Montpellier | 11,587 | Stade Gabriel Montpied | Benoît Bastien | Match Report | |
| 36 | Sun | 2022-05-08 | 15:00 | Angers | 2.9 | 4–1 | 0.8 | Bordeaux | 10,852 | Stade Raymond Kopa | Benoît Millot | Match Report | |
| 36 | Sun | 2022-05-08 | 15:00 | Reims | 0.5 | 1–2 | 1.8 | Lens | 16,962 | Stade Auguste-Delaune | Vitor Ferreira Fernandes | Match Report | |
| 36 | Sun | 2022-05-08 | 17:05 | Lorient | 0.2 | 0–3 | 1.6 | Marseille | 16,210 | Stade du Moustoir | Bastien Dechepy | Match Report | |
| 36 | Sun | 2022-05-08 | 20:45 | Paris S-G | 2.4 | 2–2 | 1.7 | Troyes | 45,000 | Parc des Princes | Jérôme Brisard | Match Report | |
| 36 | Wed | 2022-05-11 | 19:00 | Nice | 1.4 | 4–2 | 2.1 | Saint-Étienne | 17,704 | Stade de Nice | Ruddy Buquet | Match Report | |
| 36 | Wed | 2022-05-11 | 21:00 | Nantes | 1.2 | 2–1 | 2.0 | Rennes | 26,359 | Stade de la Beaujoire - Louis Fonteneau | Antony Gautier | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Nice | 1.4 | 1–3 | 2.0 | Lille | 24,232 | Stade de Nice | Thomas Léonard | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Bordeaux | 1.0 | 0–0 | 0.6 | Lorient | 23,191 | Stade Matmut-Atlantique | Ruddy Buquet | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Montpellier | 0.7 | 0–4 | 2.7 | Paris S-G | 19,586 | Stade de la Mosson | Jeremy Stinat | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Rennes | 1.6 | 2–0 | 0.4 | Marseille | 28,811 | Roazhon Park | Benoît Bastien | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Monaco | 3.1 | 4–2 | 1.9 | Brest | 6,000 | Stade Louis II | Jérôme Brisard | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Troyes | 0.3 | 1–3 | 0.8 | Lens | 19,000 | Stade de l'Aube | François Letexier | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Strasbourg | 0.9 | 1–0 | 0.7 | Clermont Foot | 25,231 | Stade de la Meinau | Benoît Millot | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Metz | 0.4 | 1–0 | 0.7 | Angers | 17,213 | Stade Saint-Symphorien | Jérémie Pignard | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Lyon | 2.2 | 3–2 | 2.0 | Nantes | 54,404 | Groupama Stadium | Florent Batta | Match Report | |
| 37 | Sat | 2022-05-14 | 21:00 | Saint-Étienne | 1.6 | 1–2 | 2.0 | Reims | Stade Geoffroy-Guichard | Clément Turpin | Match Report | ||
| 38 | Sat | 2022-05-21 | 21:00 | Lille | 1.8 | 2–2 | 1.2 | Rennes | 40,116 | Stade Pierre-Mauroy | Amaury Delerue | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Brest | 0.9 | 2–4 | 2.8 | Bordeaux | 14,484 | Stade Francis-Le Blé | Hakim Ben El Hadj Salem | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Nantes | 2.0 | 1–1 | 1.6 | Saint-Étienne | 28,636 | Stade de la Beaujoire - Louis Fonteneau | François Letexier | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Clermont Foot | 2.3 | 1–2 | 2.0 | Lyon | 12,000 | Stade Gabriel Montpied | Mikael Lesage | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Angers | 2.5 | 2–0 | 1.6 | Montpellier | 11,249 | Stade Raymond Kopa | Romain Lissorgue | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Lorient | 1.2 | 1–1 | 0.4 | Troyes | 15,131 | Stade du Moustoir | Johan Hamel | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Paris S-G | 5.4 | 5–0 | 0.7 | Metz | 45,000 | Parc des Princes | Antony Gautier | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Reims | 0.7 | 2–3 | 1.8 | Nice | 12,589 | Stade Auguste-Delaune | Eric Wattellier | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Marseille | 2.3 | 4–0 | 1.1 | Strasbourg | 63,873 | Orange Vélodrome | Stéphanie Frappart | Match Report | |
| 38 | Sat | 2022-05-21 | 21:00 | Lens | 1.6 | 2–2 | 1.4 | Monaco | 37,764 | Stade Bollaert-Delelis | Benoît Bastien | Match Report |
| Day | Date | Time | Home | xG | Score | xG | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thu | 2022-05-26 | 19:00 | Auxerre | 1–1 | Saint-Étienne | 17,479 | Stade de l'Abbé Deschamps | Match Report | Leg 1 of 2 | |||
| Sun | 2022-05-29 | 19:00 | Saint-Étienne | (4) 1–1 (5) | Auxerre | 24,489 | Stade Geoffroy-Guichard | Match Report | Leg 2 of 2; Auxerre won; Auxerre won on penalty kicks following extra time |
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