Play-off round (August 17, 2021 to August 25, 2021)
Malmö won on aggregate score over two legs and advance to Group stage.
Aug 18
Young Boys
Ferencváros
Aug 24
Ferencváros
Young Boys
Young Boys won on aggregate score over two legs and advance to Group stage.
Aug 17
RB Salzburg
Brøndby
Aug 25
Brøndby
RB Salzburg
RB Salzburg won on aggregate score over two legs and advance to Group stage.
Aug 18
Benfica
PSV Eindhoven
Aug 24
PSV Eindhoven
Benfica
Benfica won on aggregate score over two legs and advance to Group stage.
Aug 17
Sheriff Tiraspol
Dinamo Zagreb
Aug 25
Dinamo Zagreb
Sheriff Tiraspol
Sheriff Tiraspol won on aggregate score over two legs and advance to Group stage.
Shakhtar won on aggregate score over two legs, after extra time and advance to Group stage.
Third qualifying round (August 3, 2021 to August 10, 2021)
Aug 3
Red Star
Sheriff Tiraspol
Aug 10
Sheriff Tiraspol
Red Star
Sheriff Tiraspol won on aggregate score over two legs and advance to Play-off round.
Aug 4
Ferencváros
Slavia Prague
Aug 10
Slavia Prague
Ferencváros
Ferencváros won on aggregate score over two legs and advance to Play-off round.
Shakhtar won on aggregate score over two legs and advance to Play-off round.
Aug 3
Olympiacos
Ludogorets
Aug 10
Ludogorets
Olympiacos
Ludogorets won on penalty kicks following extra time and advance to Play-off round.
Aug 3
PSV Eindhoven
Midtjylland
Aug 10
Midtjylland
PSV Eindhoven
PSV Eindhoven won on aggregate score over two legs and advance to Play-off round.
Malmö won on aggregate score over two legs and advance to Play-off round.
Aug 4
Spartak Moscow
Benfica
Aug 10
Benfica
Spartak Moscow
Benfica won on aggregate score over two legs and advance to Play-off round.
Aug 4
Dinamo Zagreb
Legia Warsaw
Aug 10
Legia Warsaw
Dinamo Zagreb
Dinamo Zagreb won on aggregate score over two legs and advance to Play-off round.
Aug 3
Sparta Prague
Monaco
Aug 10
Monaco
Sparta Prague
Monaco won on aggregate score over two legs and advance to Play-off round.
Aug 3
CFR Cluj
Young Boys
Aug 10
Young Boys
CFR Cluj
Young Boys won on aggregate score over two legs and advance to Play-off round.
Second qualifying round (July 20, 2021 to July 28, 2021)
Jul 20
Dinamo Zagreb
AC Omonia
Jul 27
AC Omonia
Dinamo Zagreb
Dinamo Zagreb won on aggregate score over two legs and advance to Third qualifying round.
CFR Cluj won on aggregate score over two legs and advance to Third qualifying round.
Jul 21
NŠ Mura
Ludogorets
Jul 28
Ludogorets
NŠ Mura
Ludogorets won on aggregate score over two legs and advance to Third qualifying round.
Jul 20
Ferencváros
Žalgiris
Jul 27
Žalgiris
Ferencváros
Ferencváros won on aggregate score over two legs and advance to Third qualifying round.
Jul 21
Legia Warsaw
Flora
Jul 27
Flora
Legia Warsaw
Legia Warsaw won on aggregate score over two legs and advance to Third qualifying round.
Jul 21
Qaırat Almaty
Red Star
Jul 28
Red Star
Qaırat Almaty
Red Star won on aggregate score over two legs and advance to Third qualifying round.
Jul 20
Rapid Wien
Sparta Prague
Jul 28
Sparta Prague
Rapid Wien
Sparta Prague won on aggregate score over two legs and advance to Third qualifying round.
Jul 21
Slovan Bratislava
Young Boys
Jul 28
Young Boys
Slovan Bratislava
Young Boys won on aggregate score over two legs and advance to Third qualifying round.
Jul 20
Celtic
Midtjylland
Jul 28
Midtjylland
Celtic
Midtjylland won on aggregate score over two legs, after extra time and advance to Third qualifying round.
Olympiacos won on aggregate score over two legs and advance to Third qualifying round.
Malmö won on aggregate score over two legs and advance to Third qualifying round.
Jul 20
Alashkert
Sheriff Tiraspol
Jul 28
Sheriff Tiraspol
Alashkert
Sheriff Tiraspol won on aggregate score over two legs and advance to Third qualifying round.
Jul 21
PSV Eindhoven
Galatasaray
Jul 28
Galatasaray
PSV Eindhoven
PSV Eindhoven won on aggregate score over two legs and advance to Third qualifying round.
First qualifying round (July 6, 2021 to July 14, 2021)
Flora won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Maccabi Haifa
Qaırat Almaty
Jul 14
Qaırat Almaty
Maccabi Haifa
Qaırat Almaty won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Teuta Durrës
Sheriff Tiraspol
Jul 13
Sheriff Tiraspol
Teuta Durrës
Sheriff Tiraspol won on aggregate score over two legs and advance to Second qualifying round.
Žalgiris won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Ludogorets
Shakhtyor
Jul 13
Shakhtyor
Ludogorets
Ludogorets won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Connah's Quay
Alashkert
Jul 14
Alashkert
Connah's Quay
Alashkert won on aggregate score over two legs, after extra time and advance to Second qualifying round.
Jul 6
Ferencváros
FC Prishtina
Jul 13
FC Prishtina
Ferencváros
Ferencváros won on aggregate score over two legs and advance to Second qualifying round.
Malmö won on aggregate score over two legs and advance to Second qualifying round.
Jul 13
Red Imps
Fola Esch
Red Imps won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Dinamo Zagreb
Valur
Jul 13
Valur
Dinamo Zagreb
Dinamo Zagreb won on aggregate score over two legs and advance to Second qualifying round.
Jul 6
CFR Cluj
Borac Banja Luka
Jul 13
Borac Banja Luka
CFR Cluj
CFR Cluj won on aggregate score over two legs, after extra time and advance to Second qualifying round.
Jul 6
Shkëndija 79
NŠ Mura
Jul 13
NŠ Mura
Shkëndija 79
NŠ Mura won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Bodø/Glimt
Legia Warsaw
Jul 14
Legia Warsaw
Bodø/Glimt
Legia Warsaw won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Dinamo Tbilisi
Neftçi
Jul 14
Neftçi
Dinamo Tbilisi
Neftçi won on aggregate score over two legs and advance to Second qualifying round.
Jul 7
Slovan Bratislava
Shamrock Rov
Jul 13
Shamrock Rov
Slovan Bratislava
Slovan Bratislava won on aggregate score over two legs and advance to Second qualifying round.
HJK won on aggregate score over two legs and advance to Second qualifying round.
Preliminary round — Final (June 25, 2021)
FC Prishtina won match in normal time and advance to First qualifying round.
Preliminary round — Semi-finals (June 22, 2021)
FC Prishtina won match in normal time and advance to Preliminary round — Final.
Inter d'Escaldes won match in normal time and advance to Preliminary round — Final.
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