Scores & Fixtures 2021-2022 Eerste Divisie
| Wk | Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-06 | 20:00 | Telstar | 1–1 | Emmen | 1,400 | BUKO Stadion | Marc Nagtegaal | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Excelsior | 0–1 | Oss | 1,500 | Van Donge & De Roo Stadion | Clay Ruperti | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Den Bosch | 2–0 | Helmond Sport | 2,565 | Sportpark De Vliert (BVV) | Laurens Gerrets | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | FC Eindhoven | 2–2 | Volendam | 1,823 | Jan Louwers Stadion | Sam Dröge | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Dordrecht | 1–1 | Jong PSV | 818 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 1 | Sat | 2021-08-07 | 16:30 | De Graafschap | 0–3 | Roda JC | 6,364 | Stadion De Vijverberg | Jochem Kamphuis | Match Report | |
| 1 | Sun | 2021-08-08 | 12:15 | ADO Den Haag | 2–0 | Jong Ajax | 3,057 | Cars Jeans Stadion | Ingmar Oostrom | Match Report | |
| 1 | Sun | 2021-08-08 | 14:30 | VVV-Venlo | 2–2 | NAC Breda | 4,632 | Seacon Stadion De Koel | Rob Dieperink | Match Report | |
| 1 | Mon | 2021-08-09 | 20:00 | Jong Utrecht | 0–1 | MVV Maastricht | 541 | Sportcomplex Zoudenbalch | Erwin Blank | Match Report | |
| 1 | Mon | 2021-08-09 | 20:00 | Jong AZ | 2–1 | Almere City | 270 | AFAS Trainingscomplex | Martijn Vos | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Emmen | 0–1 | FC Eindhoven | 5,556 | De Oude Meerdijk | Sander Van der Eijk | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Volendam | 1–3 | ADO Den Haag | Kras Stadion | Alex Bos | Match Report | ||
| 2 | Fri | 2021-08-13 | 20:00 | Roda JC | 1–2 | Excelsior | 5,200 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Almere City | 1–1 | Jong Utrecht | 1,786 | Yanmar Stadion | Robin Gansner | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Oss | 2–1 | VVV-Venlo | 1,576 | Frans Heesen Stadion | Ingmar Oostrom | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | MVV Maastricht | 1–3 | De Graafschap | 3,248 | De Geusselt | Clay Ruperti | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Helmond Sport | 1–2 | Jong AZ | 1,568 | SolarUnie Stadion | Nick Smit | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | NAC Breda | 2–2 | Telstar | 10,118 | Rat Verlegh Stadion | Laurens Gerrets | Match Report | |
| 2 | Mon | 2021-08-16 | 20:00 | Jong Ajax | 1–2 | Dordrecht | Sportpark De Toekomst | Martijn Vos | Match Report | ||
| 2 | Mon | 2021-08-16 | 20:00 | Jong PSV | 0–1 | Den Bosch | Sportcomplex De Herdgang | Sam Dröge | Match Report | ||
| 3 | Fri | 2021-08-20 | 20:00 | Den Bosch | 2–3 | Jong Ajax | 3,167 | Sportpark De Vliert (BVV) | Martin Perez | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Telstar | 3–4 | Roda JC | 1,824 | BUKO Stadion | Robin Gansner | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Dordrecht | 2–2 | Jong Utrecht | 1,158 | Riwal Hoogwerkers Stadion | Nick Smit | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | MVV Maastricht | 3–2 | Helmond Sport | 3,094 | De Geusselt | Robin Hensgens | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | De Graafschap | 2–0 | NAC Breda | 7,602 | Stadion De Vijverberg | Joey Kooij | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Excelsior | 1–1 | Volendam | 2,010 | Van Donge & De Roo Stadion | Erwin Blank | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | ADO Den Haag | 1–2 | Emmen | 5,453 | Cars Jeans Stadion | Richard Martens | Match Report | |
| 3 | Sat | 2021-08-21 | 16:30 | VVV-Venlo | 2–1 | Almere City | 3,832 | Seacon Stadion De Koel | Jeroen Manschot | Match Report | |
| 3 | Mon | 2021-08-23 | 20:00 | Jong PSV | 3–2 | FC Eindhoven | 1,078 | Sportcomplex De Herdgang | Clay Ruperti | Match Report | |
| 3 | Mon | 2021-08-23 | 20:00 | Jong AZ | 1–0 | Oss | 270 | AFAS Trainingscomplex | Laurens Gerrets | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | VVV-Venlo | 0–1 | Jong AZ | 3,788 | Seacon Stadion De Koel | Robin Gansner | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Jong Utrecht | 3–0 | Telstar | 294 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | FC Eindhoven | 1–0 | Den Bosch | 1,867 | Jan Louwers Stadion | Martijn Vos | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Roda JC | 3–4 | Almere City | 5,793 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Emmen | 0–2 | De Graafschap | 5,566 | De Oude Meerdijk | Pol van Boekel | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Volendam | 5–0 | MVV Maastricht | 3,486 | Kras Stadion | Rob Dieperink | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Helmond Sport | 1–0 | Jong PSV | 1,634 | SolarUnie Stadion | Marc Nagtegaal | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | NAC Breda | 3–0 | ADO Den Haag | 11,871 | Rat Verlegh Stadion | Edwin van de Graaf | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Jong Ajax | 1–2 | Excelsior | Sportpark De Toekomst | Joey Kooij | Match Report | ||
| 4 | Sat | 2021-08-28 | 16:30 | Oss | 3–0 | Dordrecht | 1,375 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 5 | Fri | 2021-09-03 | 18:45 | Den Bosch | 0–5 | Excelsior | 2,927 | Sportpark De Vliert (BVV) | Robin Hensgens | Match Report | |
| 5 | Fri | 2021-09-03 | 21:00 | Helmond Sport | 1–0 | Emmen | 1,802 | SolarUnie Stadion | Jesse Rozendal | Match Report | |
| 5 | Sat | 2021-09-04 | 16:30 | Almere City | 3–0 | Oss | 2,011 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 5 | Sun | 2021-09-05 | 14:30 | MVV Maastricht | 3–0 | Telstar | 3,054 | De Geusselt | Sander Van der Eijk | Match Report | |
| 5 | Sun | 2021-09-05 | 16:45 | ADO Den Haag | 4–2 | FC Eindhoven | 3,633 | Cars Jeans Stadion | Jannick van der Laan | Match Report | |
| 5 | Sun | 2021-09-05 | 20:00 | Dordrecht | 0–1 | VVV-Venlo | 1,258 | Riwal Hoogwerkers Stadion | Alex Bos | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Roda JC | 0–0 | NAC Breda | 7,034 | Parkstad Limburg Stadion | Martin van den Kerkhof | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Jong PSV | 3–1 | Jong Ajax | 1,258 | Sportcomplex De Herdgang | Jesse Rozendal | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Emmen | 7–1 | MVV Maastricht | 5,566 | De Oude Meerdijk | Edwin van de Graaf | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Excelsior | 3–1 | Dordrecht | 2,361 | Van Donge & De Roo Stadion | Robin Gansner | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Jong AZ | 0–1 | Jong Utrecht | 270 | AFAS Trainingscomplex | Sam Dröge | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | De Graafschap | 0–3 | Volendam | 8,112 | Stadion De Vijverberg | Dennis Higler | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | VVV-Venlo | 2–1 | Den Bosch | 4,668 | Seacon Stadion De Koel | Kevin Blom | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Oss | 3–3 | ADO Den Haag | 1,553 | Frans Heesen Stadion | Joey Kooij | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Telstar | 1–1 | Almere City | 1,563 | BUKO Stadion | Nick Smit | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong Ajax | 6–3 | NAC Breda | 554 | Sportpark De Toekomst | Ingmar Oostrom | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Volendam | 2–2 | Roda JC | 3,283 | Kras Stadion | Clay Ruperti | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong AZ | 2–1 | De Graafschap | 554 | AFAS Trainingscomplex | Martin Perez | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong Utrecht | 2–1 | Jong PSV | 294 | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | |
| 6 | Mon | 2021-09-13 | 20:00 | FC Eindhoven | 3–2 | Helmond Sport | 1,705 | Jan Louwers Stadion | Richard Martens | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Dordrecht | 0–1 | Telstar | 1,358 | Riwal Hoogwerkers Stadion | Jesse Rozendal | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | De Graafschap | 3–1 | Excelsior | 7,274 | Stadion De Vijverberg | Bas Nijhuis | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Den Bosch | 2–1 | Jong AZ | 2,811 | Sportpark De Vliert (BVV) | Luca Cantineau | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Almere City | 2–4 | Jong Ajax | 2,652 | Yanmar Stadion | Robin Hensgens | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Helmond Sport | 0–3 | Jong Utrecht | 1,687 | SolarUnie Stadion | Robin Gansner | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Volendam | 2–1 | VVV-Venlo | 3,687 | Kras Stadion | Marc Nagtegaal | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Roda JC | 2–0 | Oss | 6,155 | Parkstad Limburg Stadion | Martijn Vos | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | MVV Maastricht | 1–0 | FC Eindhoven | 3,325 | De Geusselt | Erwin Blank | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | NAC Breda | 1–2 | Emmen | 11,861 | Rat Verlegh Stadion | Allard Lindhout | Match Report | |
| 7 | Mon | 2021-09-20 | 20:00 | Jong PSV | 0–1 | ADO Den Haag | 631 | Sportcomplex De Herdgang | Nick Smit | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | VVV-Venlo | 1–0 | Helmond Sport | 5,212 | Seacon Stadion De Koel | Clay Ruperti | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | FC Eindhoven | 2–0 | NAC Breda | 2,670 | Jan Louwers Stadion | Rob Dieperink | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | ADO Den Haag | 2–0 | Roda JC | 6,015 | Cars Jeans Stadion | Serdar Gözübüyük | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | De Graafschap | 2–2 | Jong Utrecht | 7,698 | Stadion De Vijverberg | Jannick van der Laan | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Excelsior | 3–0 | Jong PSV | 2,034 | Van Donge & De Roo Stadion | Erwin Blank | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Telstar | 1–0 | Jong AZ | 2,832 | BUKO Stadion | Robin Gansner | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Almere City | 2–2 | Dordrecht | 2,104 | Yanmar Stadion | Luca Cantineau | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Oss | 2–3 | Volendam | 1,639 | Frans Heesen Stadion | Jesse Rozendal | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Emmen | 2–0 | Den Bosch | 5,566 | De Oude Meerdijk | Richard Martens | Match Report | |
| 8 | Mon | 2021-09-27 | 20:00 | Jong Ajax | 3–1 | MVV Maastricht | 450 | Sportpark De Toekomst | Martin Perez | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Helmond Sport | 3–1 | Jong Ajax | 1,834 | SolarUnie Stadion | Nick Smit | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | NAC Breda | 4–1 | Excelsior | 14,823 | Rat Verlegh Stadion | Danny Makkelie | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Volendam | 3–2 | Almere City | 6,045 | Kras Stadion | Jannick van der Laan | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Oss | 0–3 | De Graafschap | 1,982 | Frans Heesen Stadion | Alex Bos | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong PSV | 2–1 | VVV-Venlo | 911 | Sportcomplex De Herdgang | Robin Hensgens | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | MVV Maastricht | 2–6 | ADO Den Haag | 3,500 | De Geusselt | Marc Nagtegaal | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Den Bosch | 0–1 | Telstar | 2,807 | Sportpark De Vliert (BVV) | Sam Dröge | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong AZ | 2–1 | Dordrecht | 322 | AFAS Trainingscomplex | Martijn Vos | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Roda JC | 2–0 | FC Eindhoven | 6,099 | Parkstad Limburg Stadion | Martin Perez | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong Utrecht | 0–1 | Emmen | 391 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 10 | Sat | 2021-10-09 | 16:30 | VVV-Venlo | 2–0 | MVV Maastricht | 6,024 | Seacon Stadion De Koel | Richard Martens | Match Report | |
| 10 | Sat | 2021-10-09 | 18:45 | Emmen | 0–1 | Excelsior | 7,625 | De Oude Meerdijk | Laurens Gerrets | Match Report | |
| 10 | Sat | 2021-10-09 | 21:00 | FC Eindhoven | 2–1 | Oss | 2,162 | Jan Louwers Stadion | Robin Gansner | Match Report | |
| 10 | Sun | 2021-10-10 | 14:30 | ADO Den Haag | 3–2 | Den Bosch | 5,283 | Cars Jeans Stadion | Robin Hensgens | Match Report | |
| 10 | Sun | 2021-10-10 | 16:45 | Dordrecht | 0–1 | Helmond Sport | 1,458 | Riwal Hoogwerkers Stadion | Sam Dröge | Match Report | |
| 10 | Sun | 2021-10-10 | 20:00 | Almere City | 1–2 | De Graafschap | 3,007 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | MVV Maastricht | 2–1 | Dordrecht | 3,222 | De Geusselt | Laurens Gerrets | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | De Graafschap | 0–0 | FC Eindhoven | 8,734 | Stadion De Vijverberg | Martin van den Kerkhof | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Den Bosch | 1–0 | Almere City | 2,672 | Sportpark De Vliert (BVV) | Ingmar Oostrom | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Roda JC | 2–2 | Jong PSV | 5,878 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | NAC Breda | 1–0 | Jong AZ | 15,254 | Rat Verlegh Stadion | Jannick van der Laan | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Helmond Sport | 0–0 | ADO Den Haag | 2,129 | SolarUnie Stadion | Sander Van der Eijk | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Telstar | 1–5 | Volendam | 2,615 | BUKO Stadion | Edwin van de Graaf | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Excelsior | 3–0 | VVV-Venlo | 2,734 | Van Donge & De Roo Stadion | Rob Dieperink | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Oss | 1–2 | Emmen | 1,532 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Jong Ajax | 3–1 | Jong Utrecht | 592 | Sportpark De Toekomst | Martijn Vos | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong Utrecht | 1–2 | Roda JC | 396 | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong AZ | 1–1 | Jong Ajax | 800 | AFAS Trainingscomplex | Jesse Rozendal | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong PSV | 2–3 | Telstar | 328 | Sportcomplex De Herdgang | Martin Perez | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Volendam | 1–0 | NAC Breda | 4,971 | Kras Stadion | Bas Nijhuis | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | NAC Breda | 3–0 | MVV Maastricht | 14,874 | Rat Verlegh Stadion | Edwin van de Graaf | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | VVV-Venlo | 1–2 | De Graafschap | 5,657 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Almere City | 3–5 | Jong PSV | 2,262 | Yanmar Stadion | Sam Dröge | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | FC Eindhoven | 1–3 | Jong Ajax | 2,106 | Jan Louwers Stadion | Clay Ruperti | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | ADO Den Haag | 0–2 | Excelsior | 7,018 | Cars Jeans Stadion | Joey Kooij | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Dordrecht | 3–3 | Den Bosch | 1,358 | Riwal Hoogwerkers Stadion | Nick Smit | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Jong Utrecht | 2–1 | Oss | 194 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Telstar | 2–2 | Helmond Sport | 1,625 | BUKO Stadion | Luca Cantineau | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Jong AZ | 0–1 | Volendam | 450 | AFAS Trainingscomplex | Ingmar Oostrom | Match Report | |
| 12 | Sat | 2021-10-23 | 16:30 | Roda JC | 1–2 | Emmen | 5,500 | Parkstad Limburg Stadion | Pol van Boekel | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Volendam | 4–2 | Dordrecht | 4,103 | Kras Stadion | Erwin Blank | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Emmen | 1–0 | VVV-Venlo | 7,402 | De Oude Meerdijk | Sander Van der Eijk | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | De Graafschap | 1–0 | ADO Den Haag | 9,454 | Stadion De Vijverberg | Allard Lindhout | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Den Bosch | 2–1 | Jong Utrecht | 2,700 | Sportpark De Vliert (BVV) | Marc Nagtegaal | Match Report | |
| 13 | Sat | 2021-10-30 | 16:30 | Excelsior | 3–4 | FC Eindhoven | 2,534 | Van Donge & De Roo Stadion | Martijn Vos | Match Report | |
| 13 | Sat | 2021-10-30 | 20:00 | Oss | 1–3 | NAC Breda | 1,396 | Frans Heesen Stadion | Jochem Kamphuis | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Helmond Sport | 1–2 | Almere City | 1,935 | SolarUnie Stadion | Laurens Gerrets | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Jong PSV | 2–0 | Jong AZ | 348 | Sportcomplex De Herdgang | Nick Smit | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Jong Ajax | 3–0 | Telstar | 850 | Sportpark De Toekomst | Sam Dröge | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Helmond Sport | 0–3 | Roda JC | 2,102 | SolarUnie Stadion | Jannick van der Laan | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong Utrecht | 0–6 | FC Eindhoven | 325 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Dordrecht | 2–1 | NAC Breda | 1,958 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Volendam | 2–2 | Emmen | 5,578 | Kras Stadion | Serdar Gözübüyük | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong AZ | 0–1 | MVV Maastricht | 300 | AFAS Trainingscomplex | Luuk Timmer | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | VVV-Venlo | 1–3 | Jong Ajax | 4,777 | Seacon Stadion De Koel | Robin Gansner | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong PSV | 2–2 | Oss | 428 | Sportcomplex De Herdgang | Michael Eijgelsheim | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Den Bosch | 2–1 | De Graafschap | 4,378 | Sportpark De Vliert (BVV) | Erwin Blank | Match Report | |
| 14 | Sat | 2021-11-06 | 16:30 | Telstar | 2–5 | Excelsior | 2,763 | BUKO Stadion | Jeroen Manschot | Match Report | |
| 14 | Sun | 2021-11-07 | 12:15 | Almere City | 1–3 | ADO Den Haag | 3,090 | Yanmar Stadion | Martin van den Kerkhof | Match Report | |
| 15 | Fri | 2021-11-12 | 21:00 | Oss | 0–0 | Helmond Sport | 1,163 | Frans Heesen Stadion | Nick Smit | Match Report | |
| 15 | Sat | 2021-11-13 | 16:00 | FC Eindhoven | 5–1 | Dordrecht | 2,038 | Jan Louwers Stadion | R. Vereijken | Match Report | |
| 15 | Sun | 2021-11-14 | 14:30 | De Graafschap | 1–1 | Telstar | Stadion De Vijverberg | Martijn Vos | Match Report | ||
| 15 | Sun | 2021-11-14 | 16:45 | ADO Den Haag | 2–0 | VVV-Venlo | Cars Jeans Stadion | Richard Martens | Match Report | ||
| 15 | Sun | 2021-11-14 | 20:00 | Excelsior | 4–4 | Almere City | Van Donge & De Roo Stadion | Luca Cantineau | Match Report | ||
| 15 | Mon | 2021-11-15 | 20:00 | MVV Maastricht | 0–1 | Den Bosch | De Geusselt | Martin Perez | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | NAC Breda | 1–1 | Jong Utrecht | Rat Verlegh Stadion | Rob Dieperink | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Telstar | 0–2 | ADO Den Haag | BUKO Stadion | Erwin Blank | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | VVV-Venlo | 2–0 | FC Eindhoven | Seacon Stadion De Koel | Ingmar Oostrom | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Dordrecht | 0–4 | De Graafschap | Riwal Hoogwerkers Stadion | Laurens Gerrets | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Helmond Sport | 1–5 | Excelsior | SolarUnie Stadion | Alex Bos | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Jong Ajax | 4–4 | Volendam | Sportpark De Toekomst | Robin Hensgens | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Emmen | 2–0 | Jong PSV | De Oude Meerdijk | Clay Ruperti | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Den Bosch | 1–0 | Oss | Sportpark De Vliert (BVV) | Pol van Boekel | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Almere City | 0–2 | MVV Maastricht | Yanmar Stadion | Jannick van der Laan | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Roda JC | 2–2 | Jong AZ | Parkstad Limburg Stadion | Marc Nagtegaal | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong AZ | 0–0 | Emmen | AFAS Trainingscomplex | Sam Dröge | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong Utrecht | 0–1 | Volendam | Sportcomplex Zoudenbalch | Joey Kooij | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong PSV | 0–0 | NAC Breda | Sportcomplex De Herdgang | Robin Gansner | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong Ajax | 2–1 | Roda JC | Sportpark De Toekomst | Jesse Rozendal | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Excelsior | 2–1 | Jong Utrecht | Van Donge & De Roo Stadion | Martin Perez | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Volendam | 3–0 | Den Bosch | Kras Stadion | Richard Martens | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | ADO Den Haag | 5–1 | Dordrecht | Cars Jeans Stadion | Martijn Vos | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | FC Eindhoven | 1–0 | Jong AZ | Jan Louwers Stadion | Michael Eijgelsheim | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Oss | 1–1 | Telstar | Frans Heesen Stadion | R. Vereijken | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | De Graafschap | 1–3 | Jong Ajax | Stadion De Vijverberg | Alex Bos | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | MVV Maastricht | 1–2 | Jong PSV | De Geusselt | Robin Hensgens | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Roda JC | 0–0 | VVV-Venlo | Parkstad Limburg Stadion | Erwin Blank | Match Report | ||
| 17 | Sat | 2021-11-27 | 16:30 | NAC Breda | 1–0 | Helmond Sport | Rat Verlegh Stadion | Marc Nagtegaal | Match Report | ||
| 13 | Mon | 2021-11-29 | 13:00 | MVV Maastricht | 1–1 | Roda JC | De Geusselt | Joey Kooij | Match Report | ||
| 17 | Mon | 2021-11-29 | 20:00 | Emmen | 3–0 | Almere City | De Oude Meerdijk | Ingmar Oostrom | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Dordrecht | 2–5 | Roda JC | Riwal Hoogwerkers Stadion | Luuk Timmer | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Helmond Sport | 1–1 | Volendam | SolarUnie Stadion | Martin van den Kerkhof | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | MVV Maastricht | 1–1 | Oss | De Geusselt | Sam Dröge | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Telstar | 1–3 | VVV-Venlo | BUKO Stadion | Martin Perez | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Den Bosch | 0–5 | NAC Breda | Sportpark De Vliert (BVV) | Luca Cantineau | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Almere City | 2–0 | FC Eindhoven | Yanmar Stadion | Joey Kooij | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong Ajax | 1–0 | Emmen | Sportpark De Toekomst | Jannick van der Laan | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong PSV | 2–3 | De Graafschap | Sportcomplex De Herdgang | Jesse Rozendal | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong AZ | 0–2 | Excelsior | AFAS Trainingscomplex | Robin Gansner | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong Utrecht | 1–4 | ADO Den Haag | Sportcomplex Zoudenbalch | Clay Ruperti | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | NAC Breda | 1–1 | Almere City | Rat Verlegh Stadion | Alex Bos | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | De Graafschap | 0–1 | Helmond Sport | Stadion De Vijverberg | Ingmar Oostrom | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Volendam | 3–2 | Jong PSV | Kras Stadion | Sander Van der Eijk | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Emmen | 2–1 | Dordrecht | De Oude Meerdijk | Martin Perez | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Roda JC | 3–2 | Den Bosch | Parkstad Limburg Stadion | Laurens Gerrets | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Excelsior | 2–1 | MVV Maastricht | Van Donge & De Roo Stadion | Dennis Higler | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | ADO Den Haag | 3–2 | Jong AZ | Cars Jeans Stadion | Jesse Rozendal | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | FC Eindhoven | 1–1 | Telstar | Jan Louwers Stadion | Marc Nagtegaal | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | VVV-Venlo | 1–2 | Jong Utrecht | Seacon Stadion De Koel | Michael Eijgelsheim | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Oss | 1–1 | Jong Ajax | Frans Heesen Stadion | Martijn Vos | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | VVV-Venlo | 2–3 | Oss | Seacon Stadion De Koel | Jesse Rozendal | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | Almere City | 2–3 | Volendam | Yanmar Stadion | Laurens Gerrets | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | Telstar | 0–0 | Jong PSV | BUKO Stadion | Sam Dröge | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | ADO Den Haag | 4–1 | NAC Breda | Cars Jeans Stadion | Jannick van der Laan | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | MVV Maastricht | 0–1 | Emmen | De Geusselt | Sander Van der Eijk | Match Report | ||
| 20 | Sat | 2021-12-18 | 16:30 | FC Eindhoven | 1–1 | Roda JC | Jan Louwers Stadion | Clay Ruperti | Match Report | ||
| 20 | Sat | 2021-12-18 | 20:00 | Dordrecht | 1–1 | Excelsior | Riwal Hoogwerkers Stadion | Ingmar Oostrom | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong Ajax | 1–1 | Helmond Sport | Sportpark De Toekomst | Robin Gansner | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong Utrecht | 0–2 | De Graafschap | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong AZ | 3–3 | Den Bosch | AFAS Trainingscomplex | Martijn Vos | Match Report | ||
| 21 | Fri | 2022-01-07 | 18:45 | Helmond Sport | 1–2 | Dordrecht | SolarUnie Stadion | R. Vereijken | Match Report | ||
| 21 | Fri | 2022-01-07 | 21:00 | Roda JC | 1–0 | MVV Maastricht | Parkstad Limburg Stadion | Rob Dieperink | Match Report | ||
| 21 | Sat | 2022-01-08 | 18:45 | Den Bosch | 0–2 | Emmen | Sportpark De Vliert (BVV) | Ingmar Oostrom | Match Report | ||
| 21 | Sat | 2022-01-08 | 21:00 | NAC Breda | 0–0 | FC Eindhoven | Rat Verlegh Stadion | Robin Hensgens | Match Report | ||
| 21 | Sun | 2022-01-09 | 12:15 | Volendam | 2–1 | Telstar | Kras Stadion | Joey Kooij | Match Report | ||
| 21 | Sun | 2022-01-09 | 16:45 | De Graafschap | 1–2 | VVV-Venlo | Stadion De Vijverberg | Clay Ruperti | Match Report | ||
| 21 | Mon | 2022-01-10 | 18:45 | Jong Utrecht | 0–2 | Jong Ajax | Sportcomplex Zoudenbalch | Laurens Gerrets | Match Report | ||
| 21 | Mon | 2022-01-10 | 21:00 | Jong PSV | 5–1 | Almere City | Sportcomplex De Herdgang | Erwin Blank | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | VVV-Venlo | 1–4 | Jong PSV | Seacon Stadion De Koel | Luca Cantineau | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Telstar | 2–1 | MVV Maastricht | BUKO Stadion | Robin Gansner | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | FC Eindhoven | 4–0 | Jong Utrecht | Jan Louwers Stadion | Sam Dröge | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Excelsior | 0–0 | De Graafschap | Van Donge & De Roo Stadion | Jannick van der Laan | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | NAC Breda | 0–0 | Volendam | Rat Verlegh Stadion | Marc Nagtegaal | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Almere City | 0–4 | Roda JC | Yanmar Stadion | Martijn Vos | Match Report | ||
| 22 | Sat | 2022-01-15 | 16:30 | ADO Den Haag | 2–0 | Oss | Cars Jeans Stadion | Martin Perez | Match Report | ||
| 22 | Mon | 2022-01-17 | 20:00 | Dordrecht | 2–0 | Jong AZ | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | ||
| 22 | Mon | 2022-01-17 | 20:00 | Jong Ajax | 2–1 | Den Bosch | Sportpark De Toekomst | Jesse Rozendal | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong PSV | 3–0 | Excelsior | Sportcomplex De Herdgang | Laurens Gerrets | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Roda JC | 5–0 | ADO Den Haag | Parkstad Limburg Stadion | Alex Bos | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Den Bosch | 0–2 | FC Eindhoven | Sportpark De Vliert (BVV) | Luuk Timmer | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | De Graafschap | 1–0 | Almere City | Stadion De Vijverberg | Richard Martens | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong AZ | 2–0 | VVV-Venlo | AFAS Trainingscomplex | Sam Dröge | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong Utrecht | 0–4 | Dordrecht | Sportcomplex Zoudenbalch | Martijn Vos | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | MVV Maastricht | 0–1 | Volendam | De Geusselt | Ingmar Oostrom | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Helmond Sport | 1–3 | Oss | SolarUnie Stadion | Michael Eijgelsheim | Match Report | ||
| 23 | Sat | 2022-01-22 | 16:30 | Emmen | 2–0 | NAC Breda | De Oude Meerdijk | Allard Lindhout | Match Report | ||
| 23 | Sun | 2022-01-23 | 14:30 | Telstar | 1–0 | Jong Ajax | BUKO Stadion | R. Vereijken | Match Report | ||
| 21 | Mon | 2022-01-24 | 20:00 | Oss | 1–0 | Jong AZ | Frans Heesen Stadion | Luca Cantineau | Match Report | ||
| 21 | Tue | 2022-01-25 | 20:00 | Excelsior | 2–3 | ADO Den Haag | Van Donge & De Roo Stadion | Sander Van der Eijk | Match Report | ||
| 24 | Fri | 2022-01-28 | 20:00 | Oss | 2–1 | Den Bosch | 1,520 | Frans Heesen Stadion | Alex Bos | Match Report | |
| 24 | Sat | 2022-01-29 | 16:30 | Excelsior | 0–1 | Emmen | 1,334 | Van Donge & De Roo Stadion | Richard Martens | Match Report | |
| 24 | Sat | 2022-01-29 | 18:45 | FC Eindhoven | 1–0 | MVV Maastricht | 1,400 | Jan Louwers Stadion | Martijn Vos | Match Report | |
| 24 | Sun | 2022-01-30 | 12:15 | VVV-Venlo | 4–2 | Dordrecht | 2,200 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 24 | Sun | 2022-01-30 | 14:30 | Almere City | 0–0 | Telstar | 1,523 | Yanmar Stadion | Michael Eijgelsheim | Match Report | |
| 24 | Sun | 2022-01-30 | 16:45 | ADO Den Haag | 0–0 | De Graafschap | 4,467 | Cars Jeans Stadion | Marc Nagtegaal | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Telstar | 0–3 | De Graafschap | 1,000 | BUKO Stadion | Ingmar Oostrom | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Jong PSV | 2–0 | Helmond Sport | 287 | Sportcomplex De Herdgang | Sam Dröge | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Dordrecht | 2–2 | Almere City | 1,150 | Riwal Hoogwerkers Stadion | Jesse Rozendal | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Volendam | 2–0 | Jong Utrecht | 2,166 | Kras Stadion | Clay Ruperti | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | MVV Maastricht | 0–5 | VVV-Venlo | 3,200 | De Geusselt | Erwin Blank | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Jong Ajax | 2–1 | Jong AZ | 473 | Sportpark De Toekomst | Robin Gansner | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Emmen | 3–1 | Oss | 2,770 | De Oude Meerdijk | Robin Hensgens | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | NAC Breda | 2–2 | Roda JC | 3,122 | Rat Verlegh Stadion | Luca Cantineau | Match Report | |
| 25 | Sun | 2022-02-06 | 12:15 | Den Bosch | 0–1 | ADO Den Haag | 1,698 | Sportpark De Vliert (BVV) | Laurens Gerrets | Match Report | |
| 24 | Mon | 2022-02-07 | 20:00 | Roda JC | 1–1 | Volendam | Parkstad Limburg Stadion | Richard Martens | Match Report | ||
| 24 | Mon | 2022-02-07 | 20:00 | Jong Ajax | 2–0 | Jong PSV | 480 | Sportpark De Toekomst | Michael Eijgelsheim | Match Report | |
| 24 | Mon | 2022-02-07 | 20:00 | Jong Utrecht | 3–2 | Helmond Sport | 140 | Sportcomplex Zoudenbalch | Luuk Timmer | Match Report | |
| 25 | Mon | 2022-02-07 | 20:00 | FC Eindhoven | 4–1 | Excelsior | 1,400 | Jan Louwers Stadion | Marc Nagtegaal | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Oss | 1–2 | FC Eindhoven | Frans Heesen Stadion | Sander Van der Eijk | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | Almere City | 0–0 | Emmen | Yanmar Stadion | Robin Gansner | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | ADO Den Haag | 2–3 | MVV Maastricht | Cars Jeans Stadion | Clay Ruperti | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | De Graafschap | 2–2 | Dordrecht | 3,742 | Stadion De Vijverberg | Joey Kooij | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Volendam | 2–1 | Jong AZ | 2,020 | Kras Stadion | Jannick van der Laan | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Helmond Sport | 2–2 | Telstar | 1,339 | SolarUnie Stadion | Jesse Rozendal | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Excelsior | 6–2 | Jong Ajax | 2,020 | Van Donge & De Roo Stadion | Robin Hensgens | Match Report | |
| 26 | Sun | 2022-02-13 | 12:15 | NAC Breda | 2–0 | Den Bosch | 6,314 | Rat Verlegh Stadion | Erwin Blank | Match Report | |
| 26 | Sun | 2022-02-13 | 14:30 | VVV-Venlo | 1–1 | Roda JC | Seacon Stadion De Koel | Jochem Kamphuis | Match Report | ||
| 26 | Mon | 2022-02-14 | 20:00 | Jong PSV | 0–2 | Jong Utrecht | Sportcomplex De Herdgang | R. Vereijken | Match Report | ||
| 24 | Mon | 2022-02-21 | 20:00 | Jong AZ | 0–2 | NAC Breda | AFAS Trainingscomplex | Luuk Timmer | Match Report | ||
| 27 | Mon | 2022-02-21 | 20:00 | Jong Utrecht | 0–1 | Excelsior | 263 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 27 | Mon | 2022-02-21 | 20:00 | Jong Ajax | 1–3 | Almere City | 728 | Sportpark De Toekomst | Luca Cantineau | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Excelsior | 2–0 | Roda JC | 3,130 | Van Donge & De Roo Stadion | Rob Dieperink | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Emmen | 2–1 | Jong Ajax | 7,303 | De Oude Meerdijk | Clay Ruperti | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Jong AZ | 1–3 | FC Eindhoven | 300 | AFAS Trainingscomplex | R. Vereijken | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | NAC Breda | 3–1 | Jong PSV | 10,024 | Rat Verlegh Stadion | Laurens Gerrets | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | De Graafschap | 0–0 | Den Bosch | 8,944 | Stadion De Vijverberg | Bas Nijhuis | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Oss | 4–1 | Jong Utrecht | 1,226 | Frans Heesen Stadion | Martijn Vos | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Almere City | 0–1 | VVV-Venlo | 2,467 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Volendam | 4–1 | Helmond Sport | 3,900 | Kras Stadion | Robin Hensgens | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Dordrecht | 3–1 | MVV Maastricht | 1,275 | Riwal Hoogwerkers Stadion | Richard Martens | Match Report | |
| 22 | Tue | 2022-03-01 | 20:00 | Emmen | 1–2 | Helmond Sport | De Oude Meerdijk | Alex Bos | Match Report | ||
| 29 | Fri | 2022-03-04 | 20:00 | MVV Maastricht | 1–2 | NAC Breda | 3,251 | De Geusselt | Martin Perez | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Helmond Sport | 1–2 | FC Eindhoven | 2,839 | SolarUnie Stadion | Erwin Blank | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | VVV-Venlo | 0–0 | Volendam | 5,100 | Seacon Stadion De Koel | Allard Lindhout | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | De Graafschap | 0–0 | Jong AZ | 8,869 | Stadion De Vijverberg | Martijn Vos | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Roda JC | 4–0 | Dordrecht | 5,123 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Excelsior | 4–0 | Den Bosch | 2,950 | Van Donge & De Roo Stadion | Ingmar Oostrom | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Telstar | 2–2 | Oss | 2,218 | BUKO Stadion | Clay Ruperti | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong Ajax | 6–3 | ADO Den Haag | 1,014 | Sportpark De Toekomst | Robin Gansner | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong Utrecht | 1–2 | Almere City | 1,014 | Sportcomplex Zoudenbalch | Sam Dröge | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong PSV | 1–3 | Emmen | 437 | Sportcomplex De Herdgang | Marc Nagtegaal | Match Report | |
| 30 | Mon | 2022-03-07 | 20:00 | Jong AZ | 3–2 | Telstar | 400 | AFAS Trainingscomplex | Luca Cantineau | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | NAC Breda | 2–0 | De Graafschap | 17,131 | Rat Verlegh Stadion | Jannick van der Laan | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Dordrecht | 3–3 | Jong Ajax | 2,054 | Riwal Hoogwerkers Stadion | R. Vereijken | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Den Bosch | 3–1 | MVV Maastricht | Sportpark De Vliert (BVV) | Robin Hensgens | Match Report | ||
| 30 | Fri | 2022-03-11 | 20:00 | Emmen | 2–0 | Jong Utrecht | 7,085 | De Oude Meerdijk | Rob Dieperink | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | FC Eindhoven | 4–0 | VVV-Venlo | 2,731 | Jan Louwers Stadion | Alex Bos | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Almere City | 3–0 | Helmond Sport | 2,381 | Yanmar Stadion | Martijn Vos | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Oss | 1–2 | Roda JC | 1,321 | Frans Heesen Stadion | Ingmar Oostrom | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Volendam | 2–5 | Excelsior | 5,012 | Kras Stadion | Marc Nagtegaal | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | MVV Maastricht | 2–3 | Jong AZ | De Geusselt | Alex Bos | Match Report | ||
| 27 | Mon | 2022-03-14 | 20:00 | Roda JC | 2–0 | De Graafschap | 9,350 | Parkstad Limburg Stadion | Martin Perez | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Den Bosch | 3–2 | Jong PSV | 2,382 | Sportpark De Vliert (BVV) | Robin Gansner | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Emmen | 4–1 | Volendam | 8,309 | De Oude Meerdijk | Edwin van de Graaf | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Helmond Sport | 0–3 | VVV-Venlo | 1,906 | SolarUnie Stadion | Laurens Gerrets | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | FC Eindhoven | 1–1 | ADO Den Haag | 3,111 | Jan Louwers Stadion | Joey Kooij | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Dordrecht | 1–0 | Oss | 1,015 | Riwal Hoogwerkers Stadion | Sam Dröge | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Telstar | 1–4 | NAC Breda | 2,268 | BUKO Stadion | Martijn Vos | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Almere City | 2–0 | Den Bosch | 2,406 | Yanmar Stadion | Clay Ruperti | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | ADO Den Haag | 1–1 | Volendam | 8,156 | Cars Jeans Stadion | Jeroen Manschot | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Telstar | 1–0 | Dordrecht | 1,823 | BUKO Stadion | Luuk Timmer | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Oss | 1–1 | Excelsior | 1,246 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | De Graafschap | 1–3 | MVV Maastricht | 9,265 | Stadion De Vijverberg | Laurens Gerrets | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Helmond Sport | 4–0 | NAC Breda | 2,368 | SolarUnie Stadion | Marc Nagtegaal | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong Ajax | 2–2 | FC Eindhoven | 953 | Sportpark De Toekomst | Jannick van der Laan | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong PSV | 3–3 | Roda JC | 716 | Sportcomplex De Herdgang | Richard Martens | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong Utrecht | 0–1 | Jong AZ | 192 | Sportcomplex Zoudenbalch | Nick Smit | Match Report | |
| 31 | Sat | 2022-03-19 | 16:30 | VVV-Venlo | 0–2 | Emmen | 7,856 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 28 | Mon | 2022-03-21 | 20:00 | ADO Den Haag | 2–1 | Telstar | 4,123 | Cars Jeans Stadion | Robin Hensgens | Match Report | |
| 32 | Fri | 2022-03-25 | 21:00 | FC Eindhoven | 1–2 | De Graafschap | 2,802 | Jan Louwers Stadion | Sander van der Eijk | Match Report | |
| 32 | Fri | 2022-03-25 | 21:00 | Dordrecht | 3–1 | ADO Den Haag | 2,524 | Riwal Hoogwerkers Stadion | Martijn Vos | Match Report | |
| 32 | Sat | 2022-03-26 | 16:30 | Den Bosch | 0–0 | VVV-Venlo | 3,782 | Sportpark De Vliert (BVV) | R. Vereijken | Match Report | |
| 32 | Sat | 2022-03-26 | 18:45 | Excelsior | 3–0 | Helmond Sport | 3,345 | Van Donge & De Roo Stadion | Clay Ruperti | Match Report | |
| 32 | Sun | 2022-03-27 | 14:30 | MVV Maastricht | 0–3 | Almere City | 2,300 | De Geusselt | Robin Gansner | Match Report | |
| 32 | Sun | 2022-03-27 | 16:45 | Emmen | 2–1 | Telstar | 7,704 | De Oude Meerdijk | Sam Dröge | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | De Graafschap | 1–1 | Emmen | 14,022 | Stadion De Vijverberg | Jochem Kamphuis | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | VVV-Venlo | 0–5 | ADO Den Haag | 5,259 | Seacon Stadion De Koel | Rob Dieperink | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Roda JC | 2–1 | Jong Utrecht | 4,523 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Dordrecht | 0–1 | FC Eindhoven | 1,557 | Riwal Hoogwerkers Stadion | Laurens Gerrets | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Telstar | 1–2 | Den Bosch | 1,435 | BUKO Stadion | Martin Perez | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Helmond Sport | 1–2 | MVV Maastricht | 2,344 | SolarUnie Stadion | Nick Smit | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Almere City | 3–0 | Excelsior | 2,847 | Yanmar Stadion | Dennis Higler | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Jong AZ | 2–0 | Jong PSV | 250 | AFAS Trainingscomplex | Luuk Timmer | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Volendam | 1–2 | Oss | 4,418 | Kras Stadion | Joey Kooij | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | NAC Breda | 0–0 | Jong Ajax | 17,231 | Rat Verlegh Stadion | Erwin Blank | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong AZ | 0–1 | Roda JC | 337 | AFAS Trainingscomplex | Clay Ruperti | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong Utrecht | 1–0 | NAC Breda | 583 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong PSV | 2–2 | Volendam | 367 | Sportcomplex De Herdgang | Alex Bos | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong Ajax | 4–1 | Oss | 888 | Sportpark De Toekomst | Martijn Vos | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Emmen | 3–0 | Jong AZ | 8,155 | De Oude Meerdijk | Ingmar Oostrom | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Den Bosch | 3–0 | Dordrecht | 3,287 | Sportpark De Vliert (BVV) | Nick Smit | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Excelsior | 1–4 | Telstar | 3,063 | Van Donge & De Roo Stadion | Alex Bos | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | FC Eindhoven | 3–1 | Almere City | 2,236 | Jan Louwers Stadion | Richard Martens | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Roda JC | 2–2 | Jong Ajax | 13,001 | Parkstad Limburg Stadion | Robin Gansner | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Volendam | 3–1 | De Graafschap | 5,859 | Kras Stadion | Martin van den Kerkhof | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Oss | 2–0 | Jong PSV | 1,164 | Frans Heesen Stadion | R. Vereijken | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | MVV Maastricht | 2–4 | Jong Utrecht | 2,000 | De Geusselt | Sam Dröge | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | ADO Den Haag | 2–1 | Helmond Sport | 5,743 | Cars Jeans Stadion | Jannick van der Laan | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | NAC Breda | 3–1 | VVV-Venlo | 16,632 | Rat Verlegh Stadion | Joey Kooij | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Jong AZ | 0–1 | ADO Den Haag | 475 | AFAS Trainingscomplex | Robin Gansner | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Dordrecht | 0–1 | Emmen | 3,315 | Riwal Hoogwerkers Stadion | Erwin Blank | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | VVV-Venlo | 3–2 | Telstar | 5,562 | Seacon Stadion De Koel | Michael Eijgelsheim | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | De Graafschap | 1–2 | Oss | 10,084 | Stadion De Vijverberg | Marc Nagtegaal | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | FC Eindhoven | 1–3 | Jong PSV | 4,031 | Jan Louwers Stadion | Martin Perez | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | MVV Maastricht | 1–1 | Excelsior | 2,112 | De Geusselt | Robin Hensgens | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Roda JC | 5–3 | Helmond Sport | 8,427 | Parkstad Limburg Stadion | Laurens Gerrets | Match Report | |
| 35 | Sat | 2022-04-16 | 16:30 | Volendam | 3–1 | Jong Ajax | 6,500 | Kras Stadion | Sander van der Eijk | Match Report | |
| 35 | Sat | 2022-04-16 | 21:00 | Almere City | 1–2 | NAC Breda | 3,160 | Yanmar Stadion | Rob Dieperink | Match Report | |
| 35 | Mon | 2022-04-18 | 20:00 | Jong Utrecht | 0–1 | Den Bosch | 406 | Sportcomplex Zoudenbalch | Luuk Timmer | Match Report | |
| 30 | Tue | 2022-04-19 | 20:00 | ADO Den Haag | 2–2 | Jong PSV | 3,724 | Cars Jeans Stadion | Clay Ruperti | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Oss | 2–3 | Almere City | 1,583 | Frans Heesen Stadion | Martin Perez | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Telstar | 0–1 | FC Eindhoven | 2,746 | BUKO Stadion | Martijn Vos | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | NAC Breda | 1–2 | Dordrecht | 16,576 | Rat Verlegh Stadion | Alex Bos | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Emmen | 2–0 | Roda JC | 8,309 | De Oude Meerdijk | Pol van Boekel | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Helmond Sport | 0–4 | De Graafschap | 2,319 | SolarUnie Stadion | Richard Martens | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Excelsior | 3–3 | Jong AZ | 2,934 | Van Donge & De Roo Stadion | Sam Dröge | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Den Bosch | 1–2 | Volendam | 5,328 | Sportpark De Vliert (BVV) | Jannick van der Laan | Match Report | |
| 36 | Sun | 2022-04-24 | 12:15 | ADO Den Haag | 1–1 | Jong Utrecht | 6,338 | Cars Jeans Stadion | Ingmar Oostrom | Match Report | |
| 36 | Mon | 2022-04-25 | 20:00 | Jong PSV | 2–2 | MVV Maastricht | 648 | Sportcomplex De Herdgang | Michael Eijgelsheim | Match Report | |
| 36 | Mon | 2022-04-25 | 20:00 | Jong Ajax | 6–1 | VVV-Venlo | 1,247 | Sportpark De Toekomst | Nick Smit | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | ADO Den Haag | 1–0 | Almere City | Cars Jeans Stadion | Alex Bos | Match Report | ||
| 37 | Fri | 2022-04-29 | 20:00 | FC Eindhoven | 1–0 | Emmen | 3,706 | Jan Louwers Stadion | Joey Kooij | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Dordrecht | 3–2 | Volendam | 2,022 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | De Graafschap | 1–1 | Jong PSV | Stadion De Vijverberg | Robin Gansner | Match Report | ||
| 37 | Fri | 2022-04-29 | 20:00 | VVV-Venlo | 2–2 | Excelsior | 6,223 | Seacon Stadion De Koel | Martijn Vos | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | NAC Breda | 3–0 | Oss | 15,814 | Rat Verlegh Stadion | Clay Ruperti | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Jong AZ | 0–1 | Helmond Sport | 280 | AFAS Trainingscomplex | Luca Cantineau | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | MVV Maastricht | 1–0 | Jong Ajax | 3,856 | De Geusselt | R. Vereijken | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Den Bosch | 1–0 | Roda JC | 4,869 | Sportpark De Vliert (BVV) | Erwin Blank | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Telstar | 1–3 | Jong Utrecht | BUKO Stadion | Jesse Rozendal | Match Report | ||
| 38 | Fri | 2022-05-06 | 20:00 | Helmond Sport | 1–1 | Den Bosch | 3,643 | SolarUnie Stadion | Sam Dröge | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Roda JC | 4–3 | Telstar | 8,487 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Excelsior | 2–2 | NAC Breda | 3,744 | Van Donge & De Roo Stadion | Luca Cantineau | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Oss | 0–1 | MVV Maastricht | 2,198 | Frans Heesen Stadion | Jesse Rozendal | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong PSV | 1–1 | Dordrecht | 783 | Sportcomplex De Herdgang | Luuk Timmer | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Almere City | 0–3 | Jong AZ | 3,028 | Yanmar Stadion | Erwin Blank | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Emmen | 3–0 | ADO Den Haag | 8,205 | De Oude Meerdijk | Sander van der Eijk | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Volendam | 2–2 | FC Eindhoven | 5,818 | Kras Stadion | Rob Dieperink | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong Utrecht | 2–3 | VVV-Venlo | 402 | Sportcomplex Zoudenbalch | Laurens Gerrets | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong Ajax | 1–1 | De Graafschap | 1,358 | Sportpark De Toekomst | Martin Perez | Match Report |
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FBref.com launched (June 13, 2018) with domestic league coverage for England, France, Germany, Italy, Spain, and United States. Since then we have been steadily expanding our coverage to include domestic leagues from over 40 countries as well as domestic cup, super cup and youth leagues from top European countries. We have also added coverage for major international cups such as the UEFA Champions League and Copa Libertadores.
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