Scores & Fixtures 2021-2022 Eerste Divisie
| Wk | Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Fri | 2021-08-06 | 20:00 | Telstar | 1–1 | Emmen | 1,400 | BUKO Stadion | Marc Nagtegaal | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Excelsior | 0–1 | Oss | 1,500 | Van Donge & De Roo Stadion | Clay Ruperti | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Den Bosch | 2–0 | Helmond Sport | 2,565 | Sportpark De Vliert (BVV) | Laurens Gerrets | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | FC Eindhoven | 2–2 | Volendam | 1,823 | Jan Louwers Stadion | Sam Dröge | Match Report | |
| 1 | Fri | 2021-08-06 | 20:00 | Dordrecht | 1–1 | Jong PSV | 818 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 1 | Sat | 2021-08-07 | 16:30 | De Graafschap | 0–3 | Roda JC | 6,364 | Stadion De Vijverberg | Jochem Kamphuis | Match Report | |
| 1 | Sun | 2021-08-08 | 12:15 | ADO Den Haag | 2–0 | Jong Ajax | 3,057 | Cars Jeans Stadion | Ingmar Oostrom | Match Report | |
| 1 | Sun | 2021-08-08 | 14:30 | VVV-Venlo | 2–2 | NAC Breda | 4,632 | Seacon Stadion De Koel | Rob Dieperink | Match Report | |
| 1 | Mon | 2021-08-09 | 20:00 | Jong Utrecht | 0–1 | MVV Maastricht | 541 | Sportcomplex Zoudenbalch | Erwin Blank | Match Report | |
| 1 | Mon | 2021-08-09 | 20:00 | Jong AZ | 2–1 | Almere City | 270 | AFAS Trainingscomplex | Martijn Vos | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Emmen | 0–1 | FC Eindhoven | 5,556 | De Oude Meerdijk | Sander Van der Eijk | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Volendam | 1–3 | ADO Den Haag | Kras Stadion | Alex Bos | Match Report | ||
| 2 | Fri | 2021-08-13 | 20:00 | Roda JC | 1–2 | Excelsior | 5,200 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Almere City | 1–1 | Jong Utrecht | 1,786 | Yanmar Stadion | Robin Gansner | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Oss | 2–1 | VVV-Venlo | 1,576 | Frans Heesen Stadion | Ingmar Oostrom | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | MVV Maastricht | 1–3 | De Graafschap | 3,248 | De Geusselt | Clay Ruperti | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | Helmond Sport | 1–2 | Jong AZ | 1,568 | SolarUnie Stadion | Nick Smit | Match Report | |
| 2 | Fri | 2021-08-13 | 20:00 | NAC Breda | 2–2 | Telstar | 10,118 | Rat Verlegh Stadion | Laurens Gerrets | Match Report | |
| 2 | Mon | 2021-08-16 | 20:00 | Jong Ajax | 1–2 | Dordrecht | Sportpark De Toekomst | Martijn Vos | Match Report | ||
| 2 | Mon | 2021-08-16 | 20:00 | Jong PSV | 0–1 | Den Bosch | Sportcomplex De Herdgang | Sam Dröge | Match Report | ||
| 3 | Fri | 2021-08-20 | 20:00 | Den Bosch | 2–3 | Jong Ajax | 3,167 | Sportpark De Vliert (BVV) | Martin Perez | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Telstar | 3–4 | Roda JC | 1,824 | BUKO Stadion | Robin Gansner | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Dordrecht | 2–2 | Jong Utrecht | 1,158 | Riwal Hoogwerkers Stadion | Nick Smit | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | MVV Maastricht | 3–2 | Helmond Sport | 3,094 | De Geusselt | Robin Hensgens | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | De Graafschap | 2–0 | NAC Breda | 7,602 | Stadion De Vijverberg | Joey Kooij | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | Excelsior | 1–1 | Volendam | 2,010 | Van Donge & De Roo Stadion | Erwin Blank | Match Report | |
| 3 | Fri | 2021-08-20 | 20:00 | ADO Den Haag | 1–2 | Emmen | 5,453 | Cars Jeans Stadion | Richard Martens | Match Report | |
| 3 | Sat | 2021-08-21 | 16:30 | VVV-Venlo | 2–1 | Almere City | 3,832 | Seacon Stadion De Koel | Jeroen Manschot | Match Report | |
| 3 | Mon | 2021-08-23 | 20:00 | Jong PSV | 3–2 | FC Eindhoven | 1,078 | Sportcomplex De Herdgang | Clay Ruperti | Match Report | |
| 3 | Mon | 2021-08-23 | 20:00 | Jong AZ | 1–0 | Oss | 270 | AFAS Trainingscomplex | Laurens Gerrets | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | VVV-Venlo | 0–1 | Jong AZ | 3,788 | Seacon Stadion De Koel | Robin Gansner | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Jong Utrecht | 3–0 | Telstar | 294 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | FC Eindhoven | 1–0 | Den Bosch | 1,867 | Jan Louwers Stadion | Martijn Vos | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Roda JC | 3–4 | Almere City | 5,793 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Emmen | 0–2 | De Graafschap | 5,566 | De Oude Meerdijk | Pol van Boekel | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Volendam | 5–0 | MVV Maastricht | 3,486 | Kras Stadion | Rob Dieperink | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Helmond Sport | 1–0 | Jong PSV | 1,634 | SolarUnie Stadion | Marc Nagtegaal | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | NAC Breda | 3–0 | ADO Den Haag | 11,871 | Rat Verlegh Stadion | Edwin van de Graaf | Match Report | |
| 4 | Fri | 2021-08-27 | 20:00 | Jong Ajax | 1–2 | Excelsior | Sportpark De Toekomst | Joey Kooij | Match Report | ||
| 4 | Sat | 2021-08-28 | 16:30 | Oss | 3–0 | Dordrecht | 1,375 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 5 | Fri | 2021-09-03 | 18:45 | Den Bosch | 0–5 | Excelsior | 2,927 | Sportpark De Vliert (BVV) | Robin Hensgens | Match Report | |
| 5 | Fri | 2021-09-03 | 21:00 | Helmond Sport | 1–0 | Emmen | 1,802 | SolarUnie Stadion | Jesse Rozendal | Match Report | |
| 5 | Sat | 2021-09-04 | 16:30 | Almere City | 3–0 | Oss | 2,011 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 5 | Sun | 2021-09-05 | 14:30 | MVV Maastricht | 3–0 | Telstar | 3,054 | De Geusselt | Sander Van der Eijk | Match Report | |
| 5 | Sun | 2021-09-05 | 16:45 | ADO Den Haag | 4–2 | FC Eindhoven | 3,633 | Cars Jeans Stadion | Jannick van der Laan | Match Report | |
| 5 | Sun | 2021-09-05 | 20:00 | Dordrecht | 0–1 | VVV-Venlo | 1,258 | Riwal Hoogwerkers Stadion | Alex Bos | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Roda JC | 0–0 | NAC Breda | 7,034 | Parkstad Limburg Stadion | Martin van den Kerkhof | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Jong PSV | 3–1 | Jong Ajax | 1,258 | Sportcomplex De Herdgang | Jesse Rozendal | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Emmen | 7–1 | MVV Maastricht | 5,566 | De Oude Meerdijk | Edwin van de Graaf | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Excelsior | 3–1 | Dordrecht | 2,361 | Van Donge & De Roo Stadion | Robin Gansner | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Jong AZ | 0–1 | Jong Utrecht | 270 | AFAS Trainingscomplex | Sam Dröge | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | De Graafschap | 0–3 | Volendam | 8,112 | Stadion De Vijverberg | Dennis Higler | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | VVV-Venlo | 2–1 | Den Bosch | 4,668 | Seacon Stadion De Koel | Kevin Blom | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Oss | 3–3 | ADO Den Haag | 1,553 | Frans Heesen Stadion | Joey Kooij | Match Report | |
| 6 | Fri | 2021-09-10 | 20:00 | Telstar | 1–1 | Almere City | 1,563 | BUKO Stadion | Nick Smit | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong Ajax | 6–3 | NAC Breda | 554 | Sportpark De Toekomst | Ingmar Oostrom | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Volendam | 2–2 | Roda JC | 3,283 | Kras Stadion | Clay Ruperti | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong AZ | 2–1 | De Graafschap | 554 | AFAS Trainingscomplex | Martin Perez | Match Report | |
| 5 | Mon | 2021-09-13 | 20:00 | Jong Utrecht | 2–1 | Jong PSV | 294 | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | |
| 6 | Mon | 2021-09-13 | 20:00 | FC Eindhoven | 3–2 | Helmond Sport | 1,705 | Jan Louwers Stadion | Richard Martens | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Dordrecht | 0–1 | Telstar | 1,358 | Riwal Hoogwerkers Stadion | Jesse Rozendal | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | De Graafschap | 3–1 | Excelsior | 7,274 | Stadion De Vijverberg | Bas Nijhuis | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Den Bosch | 2–1 | Jong AZ | 2,811 | Sportpark De Vliert (BVV) | Luca Cantineau | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Almere City | 2–4 | Jong Ajax | 2,652 | Yanmar Stadion | Robin Hensgens | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Helmond Sport | 0–3 | Jong Utrecht | 1,687 | SolarUnie Stadion | Robin Gansner | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Volendam | 2–1 | VVV-Venlo | 3,687 | Kras Stadion | Marc Nagtegaal | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | Roda JC | 2–0 | Oss | 6,155 | Parkstad Limburg Stadion | Martijn Vos | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | MVV Maastricht | 1–0 | FC Eindhoven | 3,325 | De Geusselt | Erwin Blank | Match Report | |
| 7 | Fri | 2021-09-17 | 20:00 | NAC Breda | 1–2 | Emmen | 11,861 | Rat Verlegh Stadion | Allard Lindhout | Match Report | |
| 7 | Mon | 2021-09-20 | 20:00 | Jong PSV | 0–1 | ADO Den Haag | 631 | Sportcomplex De Herdgang | Nick Smit | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | VVV-Venlo | 1–0 | Helmond Sport | 5,212 | Seacon Stadion De Koel | Clay Ruperti | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | FC Eindhoven | 2–0 | NAC Breda | 2,670 | Jan Louwers Stadion | Rob Dieperink | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | ADO Den Haag | 2–0 | Roda JC | 6,015 | Cars Jeans Stadion | Serdar Gözübüyük | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | De Graafschap | 2–2 | Jong Utrecht | 7,698 | Stadion De Vijverberg | Jannick van der Laan | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Excelsior | 3–0 | Jong PSV | 2,034 | Van Donge & De Roo Stadion | Erwin Blank | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Telstar | 1–0 | Jong AZ | 2,832 | BUKO Stadion | Robin Gansner | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Almere City | 2–2 | Dordrecht | 2,104 | Yanmar Stadion | Luca Cantineau | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Oss | 2–3 | Volendam | 1,639 | Frans Heesen Stadion | Jesse Rozendal | Match Report | |
| 8 | Fri | 2021-09-24 | 20:00 | Emmen | 2–0 | Den Bosch | 5,566 | De Oude Meerdijk | Richard Martens | Match Report | |
| 8 | Mon | 2021-09-27 | 20:00 | Jong Ajax | 3–1 | MVV Maastricht | 450 | Sportpark De Toekomst | Martin Perez | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Helmond Sport | 3–1 | Jong Ajax | 1,834 | SolarUnie Stadion | Nick Smit | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | NAC Breda | 4–1 | Excelsior | 14,823 | Rat Verlegh Stadion | Danny Makkelie | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Volendam | 3–2 | Almere City | 6,045 | Kras Stadion | Jannick van der Laan | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Oss | 0–3 | De Graafschap | 1,982 | Frans Heesen Stadion | Alex Bos | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong PSV | 2–1 | VVV-Venlo | 911 | Sportcomplex De Herdgang | Robin Hensgens | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | MVV Maastricht | 2–6 | ADO Den Haag | 3,500 | De Geusselt | Marc Nagtegaal | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Den Bosch | 0–1 | Telstar | 2,807 | Sportpark De Vliert (BVV) | Sam Dröge | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong AZ | 2–1 | Dordrecht | 322 | AFAS Trainingscomplex | Martijn Vos | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Roda JC | 2–0 | FC Eindhoven | 6,099 | Parkstad Limburg Stadion | Martin Perez | Match Report | |
| 9 | Fri | 2021-10-01 | 20:00 | Jong Utrecht | 0–1 | Emmen | 391 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 10 | Sat | 2021-10-09 | 16:30 | VVV-Venlo | 2–0 | MVV Maastricht | 6,024 | Seacon Stadion De Koel | Richard Martens | Match Report | |
| 10 | Sat | 2021-10-09 | 18:45 | Emmen | 0–1 | Excelsior | 7,625 | De Oude Meerdijk | Laurens Gerrets | Match Report | |
| 10 | Sat | 2021-10-09 | 21:00 | FC Eindhoven | 2–1 | Oss | 2,162 | Jan Louwers Stadion | Robin Gansner | Match Report | |
| 10 | Sun | 2021-10-10 | 14:30 | ADO Den Haag | 3–2 | Den Bosch | 5,283 | Cars Jeans Stadion | Robin Hensgens | Match Report | |
| 10 | Sun | 2021-10-10 | 16:45 | Dordrecht | 0–1 | Helmond Sport | 1,458 | Riwal Hoogwerkers Stadion | Sam Dröge | Match Report | |
| 10 | Sun | 2021-10-10 | 20:00 | Almere City | 1–2 | De Graafschap | 3,007 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | MVV Maastricht | 2–1 | Dordrecht | 3,222 | De Geusselt | Laurens Gerrets | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | De Graafschap | 0–0 | FC Eindhoven | 8,734 | Stadion De Vijverberg | Martin van den Kerkhof | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Den Bosch | 1–0 | Almere City | 2,672 | Sportpark De Vliert (BVV) | Ingmar Oostrom | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Roda JC | 2–2 | Jong PSV | 5,878 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | NAC Breda | 1–0 | Jong AZ | 15,254 | Rat Verlegh Stadion | Jannick van der Laan | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Helmond Sport | 0–0 | ADO Den Haag | 2,129 | SolarUnie Stadion | Sander Van der Eijk | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Telstar | 1–5 | Volendam | 2,615 | BUKO Stadion | Edwin van de Graaf | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Excelsior | 3–0 | VVV-Venlo | 2,734 | Van Donge & De Roo Stadion | Rob Dieperink | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Oss | 1–2 | Emmen | 1,532 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 11 | Fri | 2021-10-15 | 20:00 | Jong Ajax | 3–1 | Jong Utrecht | 592 | Sportpark De Toekomst | Martijn Vos | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong Utrecht | 1–2 | Roda JC | 396 | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong AZ | 1–1 | Jong Ajax | 800 | AFAS Trainingscomplex | Jesse Rozendal | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Jong PSV | 2–3 | Telstar | 328 | Sportcomplex De Herdgang | Martin Perez | Match Report | |
| 10 | Mon | 2021-10-18 | 20:00 | Volendam | 1–0 | NAC Breda | 4,971 | Kras Stadion | Bas Nijhuis | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | NAC Breda | 3–0 | MVV Maastricht | 14,874 | Rat Verlegh Stadion | Edwin van de Graaf | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | VVV-Venlo | 1–2 | De Graafschap | 5,657 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Almere City | 3–5 | Jong PSV | 2,262 | Yanmar Stadion | Sam Dröge | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | FC Eindhoven | 1–3 | Jong Ajax | 2,106 | Jan Louwers Stadion | Clay Ruperti | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | ADO Den Haag | 0–2 | Excelsior | 7,018 | Cars Jeans Stadion | Joey Kooij | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Dordrecht | 3–3 | Den Bosch | 1,358 | Riwal Hoogwerkers Stadion | Nick Smit | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Jong Utrecht | 2–1 | Oss | 194 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Telstar | 2–2 | Helmond Sport | 1,625 | BUKO Stadion | Luca Cantineau | Match Report | |
| 12 | Fri | 2021-10-22 | 20:00 | Jong AZ | 0–1 | Volendam | 450 | AFAS Trainingscomplex | Ingmar Oostrom | Match Report | |
| 12 | Sat | 2021-10-23 | 16:30 | Roda JC | 1–2 | Emmen | 5,500 | Parkstad Limburg Stadion | Pol van Boekel | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Volendam | 4–2 | Dordrecht | 4,103 | Kras Stadion | Erwin Blank | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Emmen | 1–0 | VVV-Venlo | 7,402 | De Oude Meerdijk | Sander Van der Eijk | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | De Graafschap | 1–0 | ADO Den Haag | 9,454 | Stadion De Vijverberg | Allard Lindhout | Match Report | |
| 13 | Fri | 2021-10-29 | 20:00 | Den Bosch | 2–1 | Jong Utrecht | 2,700 | Sportpark De Vliert (BVV) | Marc Nagtegaal | Match Report | |
| 13 | Sat | 2021-10-30 | 16:30 | Excelsior | 3–4 | FC Eindhoven | 2,534 | Van Donge & De Roo Stadion | Martijn Vos | Match Report | |
| 13 | Sat | 2021-10-30 | 20:00 | Oss | 1–3 | NAC Breda | 1,396 | Frans Heesen Stadion | Jochem Kamphuis | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Helmond Sport | 1–2 | Almere City | 1,935 | SolarUnie Stadion | Laurens Gerrets | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Jong PSV | 2–0 | Jong AZ | 348 | Sportcomplex De Herdgang | Nick Smit | Match Report | |
| 13 | Mon | 2021-11-01 | 20:00 | Jong Ajax | 3–0 | Telstar | 850 | Sportpark De Toekomst | Sam Dröge | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Helmond Sport | 0–3 | Roda JC | 2,102 | SolarUnie Stadion | Jannick van der Laan | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong Utrecht | 0–6 | FC Eindhoven | 325 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Dordrecht | 2–1 | NAC Breda | 1,958 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Volendam | 2–2 | Emmen | 5,578 | Kras Stadion | Serdar Gözübüyük | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong AZ | 0–1 | MVV Maastricht | 300 | AFAS Trainingscomplex | Luuk Timmer | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | VVV-Venlo | 1–3 | Jong Ajax | 4,777 | Seacon Stadion De Koel | Robin Gansner | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Jong PSV | 2–2 | Oss | 428 | Sportcomplex De Herdgang | Michael Eijgelsheim | Match Report | |
| 14 | Fri | 2021-11-05 | 20:00 | Den Bosch | 2–1 | De Graafschap | 4,378 | Sportpark De Vliert (BVV) | Erwin Blank | Match Report | |
| 14 | Sat | 2021-11-06 | 16:30 | Telstar | 2–5 | Excelsior | 2,763 | BUKO Stadion | Jeroen Manschot | Match Report | |
| 14 | Sun | 2021-11-07 | 12:15 | Almere City | 1–3 | ADO Den Haag | 3,090 | Yanmar Stadion | Martin van den Kerkhof | Match Report | |
| 15 | Fri | 2021-11-12 | 21:00 | Oss | 0–0 | Helmond Sport | 1,163 | Frans Heesen Stadion | Nick Smit | Match Report | |
| 15 | Sat | 2021-11-13 | 16:00 | FC Eindhoven | 5–1 | Dordrecht | 2,038 | Jan Louwers Stadion | R. Vereijken | Match Report | |
| 15 | Sun | 2021-11-14 | 14:30 | De Graafschap | 1–1 | Telstar | Stadion De Vijverberg | Martijn Vos | Match Report | ||
| 15 | Sun | 2021-11-14 | 16:45 | ADO Den Haag | 2–0 | VVV-Venlo | Cars Jeans Stadion | Richard Martens | Match Report | ||
| 15 | Sun | 2021-11-14 | 20:00 | Excelsior | 4–4 | Almere City | Van Donge & De Roo Stadion | Luca Cantineau | Match Report | ||
| 15 | Mon | 2021-11-15 | 20:00 | MVV Maastricht | 0–1 | Den Bosch | De Geusselt | Martin Perez | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | NAC Breda | 1–1 | Jong Utrecht | Rat Verlegh Stadion | Rob Dieperink | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Telstar | 0–2 | ADO Den Haag | BUKO Stadion | Erwin Blank | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | VVV-Venlo | 2–0 | FC Eindhoven | Seacon Stadion De Koel | Ingmar Oostrom | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Dordrecht | 0–4 | De Graafschap | Riwal Hoogwerkers Stadion | Laurens Gerrets | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Helmond Sport | 1–5 | Excelsior | SolarUnie Stadion | Alex Bos | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Jong Ajax | 4–4 | Volendam | Sportpark De Toekomst | Robin Hensgens | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Emmen | 2–0 | Jong PSV | De Oude Meerdijk | Clay Ruperti | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Den Bosch | 1–0 | Oss | Sportpark De Vliert (BVV) | Pol van Boekel | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Almere City | 0–2 | MVV Maastricht | Yanmar Stadion | Jannick van der Laan | Match Report | ||
| 16 | Fri | 2021-11-19 | 20:00 | Roda JC | 2–2 | Jong AZ | Parkstad Limburg Stadion | Marc Nagtegaal | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong AZ | 0–0 | Emmen | AFAS Trainingscomplex | Sam Dröge | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong Utrecht | 0–1 | Volendam | Sportcomplex Zoudenbalch | Joey Kooij | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong PSV | 0–0 | NAC Breda | Sportcomplex De Herdgang | Robin Gansner | Match Report | ||
| 15 | Mon | 2021-11-22 | 20:00 | Jong Ajax | 2–1 | Roda JC | Sportpark De Toekomst | Jesse Rozendal | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Excelsior | 2–1 | Jong Utrecht | Van Donge & De Roo Stadion | Martin Perez | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Volendam | 3–0 | Den Bosch | Kras Stadion | Richard Martens | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | ADO Den Haag | 5–1 | Dordrecht | Cars Jeans Stadion | Martijn Vos | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | FC Eindhoven | 1–0 | Jong AZ | Jan Louwers Stadion | Michael Eijgelsheim | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Oss | 1–1 | Telstar | Frans Heesen Stadion | R. Vereijken | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | De Graafschap | 1–3 | Jong Ajax | Stadion De Vijverberg | Alex Bos | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | MVV Maastricht | 1–2 | Jong PSV | De Geusselt | Robin Hensgens | Match Report | ||
| 17 | Fri | 2021-11-26 | 20:00 | Roda JC | 0–0 | VVV-Venlo | Parkstad Limburg Stadion | Erwin Blank | Match Report | ||
| 17 | Sat | 2021-11-27 | 16:30 | NAC Breda | 1–0 | Helmond Sport | Rat Verlegh Stadion | Marc Nagtegaal | Match Report | ||
| 13 | Mon | 2021-11-29 | 13:00 | MVV Maastricht | 1–1 | Roda JC | De Geusselt | Joey Kooij | Match Report | ||
| 17 | Mon | 2021-11-29 | 20:00 | Emmen | 3–0 | Almere City | De Oude Meerdijk | Ingmar Oostrom | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Dordrecht | 2–5 | Roda JC | Riwal Hoogwerkers Stadion | Luuk Timmer | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Helmond Sport | 1–1 | Volendam | SolarUnie Stadion | Martin van den Kerkhof | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | MVV Maastricht | 1–1 | Oss | De Geusselt | Sam Dröge | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Telstar | 1–3 | VVV-Venlo | BUKO Stadion | Martin Perez | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Den Bosch | 0–5 | NAC Breda | Sportpark De Vliert (BVV) | Luca Cantineau | Match Report | ||
| 18 | Fri | 2021-12-03 | 20:00 | Almere City | 2–0 | FC Eindhoven | Yanmar Stadion | Joey Kooij | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong Ajax | 1–0 | Emmen | Sportpark De Toekomst | Jannick van der Laan | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong PSV | 2–3 | De Graafschap | Sportcomplex De Herdgang | Jesse Rozendal | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong AZ | 0–2 | Excelsior | AFAS Trainingscomplex | Robin Gansner | Match Report | ||
| 18 | Mon | 2021-12-06 | 20:00 | Jong Utrecht | 1–4 | ADO Den Haag | Sportcomplex Zoudenbalch | Clay Ruperti | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | NAC Breda | 1–1 | Almere City | Rat Verlegh Stadion | Alex Bos | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | De Graafschap | 0–1 | Helmond Sport | Stadion De Vijverberg | Ingmar Oostrom | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Volendam | 3–2 | Jong PSV | Kras Stadion | Sander Van der Eijk | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Emmen | 2–1 | Dordrecht | De Oude Meerdijk | Martin Perez | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Roda JC | 3–2 | Den Bosch | Parkstad Limburg Stadion | Laurens Gerrets | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Excelsior | 2–1 | MVV Maastricht | Van Donge & De Roo Stadion | Dennis Higler | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | ADO Den Haag | 3–2 | Jong AZ | Cars Jeans Stadion | Jesse Rozendal | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | FC Eindhoven | 1–1 | Telstar | Jan Louwers Stadion | Marc Nagtegaal | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | VVV-Venlo | 1–2 | Jong Utrecht | Seacon Stadion De Koel | Michael Eijgelsheim | Match Report | ||
| 19 | Fri | 2021-12-10 | 20:00 | Oss | 1–1 | Jong Ajax | Frans Heesen Stadion | Martijn Vos | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | VVV-Venlo | 2–3 | Oss | Seacon Stadion De Koel | Jesse Rozendal | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | Almere City | 2–3 | Volendam | Yanmar Stadion | Laurens Gerrets | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | Telstar | 0–0 | Jong PSV | BUKO Stadion | Sam Dröge | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | ADO Den Haag | 4–1 | NAC Breda | Cars Jeans Stadion | Jannick van der Laan | Match Report | ||
| 20 | Fri | 2021-12-17 | 20:00 | MVV Maastricht | 0–1 | Emmen | De Geusselt | Sander Van der Eijk | Match Report | ||
| 20 | Sat | 2021-12-18 | 16:30 | FC Eindhoven | 1–1 | Roda JC | Jan Louwers Stadion | Clay Ruperti | Match Report | ||
| 20 | Sat | 2021-12-18 | 20:00 | Dordrecht | 1–1 | Excelsior | Riwal Hoogwerkers Stadion | Ingmar Oostrom | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong Ajax | 1–1 | Helmond Sport | Sportpark De Toekomst | Robin Gansner | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong Utrecht | 0–2 | De Graafschap | Sportcomplex Zoudenbalch | Luca Cantineau | Match Report | ||
| 20 | Mon | 2021-12-20 | 20:00 | Jong AZ | 3–3 | Den Bosch | AFAS Trainingscomplex | Martijn Vos | Match Report | ||
| 21 | Fri | 2022-01-07 | 18:45 | Helmond Sport | 1–2 | Dordrecht | SolarUnie Stadion | R. Vereijken | Match Report | ||
| 21 | Fri | 2022-01-07 | 21:00 | Roda JC | 1–0 | MVV Maastricht | Parkstad Limburg Stadion | Rob Dieperink | Match Report | ||
| 21 | Sat | 2022-01-08 | 18:45 | Den Bosch | 0–2 | Emmen | Sportpark De Vliert (BVV) | Ingmar Oostrom | Match Report | ||
| 21 | Sat | 2022-01-08 | 21:00 | NAC Breda | 0–0 | FC Eindhoven | Rat Verlegh Stadion | Robin Hensgens | Match Report | ||
| 21 | Sun | 2022-01-09 | 12:15 | Volendam | 2–1 | Telstar | Kras Stadion | Joey Kooij | Match Report | ||
| 21 | Sun | 2022-01-09 | 16:45 | De Graafschap | 1–2 | VVV-Venlo | Stadion De Vijverberg | Clay Ruperti | Match Report | ||
| 21 | Mon | 2022-01-10 | 18:45 | Jong Utrecht | 0–2 | Jong Ajax | Sportcomplex Zoudenbalch | Laurens Gerrets | Match Report | ||
| 21 | Mon | 2022-01-10 | 21:00 | Jong PSV | 5–1 | Almere City | Sportcomplex De Herdgang | Erwin Blank | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | VVV-Venlo | 1–4 | Jong PSV | Seacon Stadion De Koel | Luca Cantineau | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Telstar | 2–1 | MVV Maastricht | BUKO Stadion | Robin Gansner | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | FC Eindhoven | 4–0 | Jong Utrecht | Jan Louwers Stadion | Sam Dröge | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Excelsior | 0–0 | De Graafschap | Van Donge & De Roo Stadion | Jannick van der Laan | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | NAC Breda | 0–0 | Volendam | Rat Verlegh Stadion | Marc Nagtegaal | Match Report | ||
| 22 | Fri | 2022-01-14 | 20:00 | Almere City | 0–4 | Roda JC | Yanmar Stadion | Martijn Vos | Match Report | ||
| 22 | Sat | 2022-01-15 | 16:30 | ADO Den Haag | 2–0 | Oss | Cars Jeans Stadion | Martin Perez | Match Report | ||
| 22 | Mon | 2022-01-17 | 20:00 | Dordrecht | 2–0 | Jong AZ | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | ||
| 22 | Mon | 2022-01-17 | 20:00 | Jong Ajax | 2–1 | Den Bosch | Sportpark De Toekomst | Jesse Rozendal | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong PSV | 3–0 | Excelsior | Sportcomplex De Herdgang | Laurens Gerrets | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Roda JC | 5–0 | ADO Den Haag | Parkstad Limburg Stadion | Alex Bos | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Den Bosch | 0–2 | FC Eindhoven | Sportpark De Vliert (BVV) | Luuk Timmer | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | De Graafschap | 1–0 | Almere City | Stadion De Vijverberg | Richard Martens | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong AZ | 2–0 | VVV-Venlo | AFAS Trainingscomplex | Sam Dröge | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Jong Utrecht | 0–4 | Dordrecht | Sportcomplex Zoudenbalch | Martijn Vos | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | MVV Maastricht | 0–1 | Volendam | De Geusselt | Ingmar Oostrom | Match Report | ||
| 23 | Fri | 2022-01-21 | 20:00 | Helmond Sport | 1–3 | Oss | SolarUnie Stadion | Michael Eijgelsheim | Match Report | ||
| 23 | Sat | 2022-01-22 | 16:30 | Emmen | 2–0 | NAC Breda | De Oude Meerdijk | Allard Lindhout | Match Report | ||
| 23 | Sun | 2022-01-23 | 14:30 | Telstar | 1–0 | Jong Ajax | BUKO Stadion | R. Vereijken | Match Report | ||
| 21 | Mon | 2022-01-24 | 20:00 | Oss | 1–0 | Jong AZ | Frans Heesen Stadion | Luca Cantineau | Match Report | ||
| 21 | Tue | 2022-01-25 | 20:00 | Excelsior | 2–3 | ADO Den Haag | Van Donge & De Roo Stadion | Sander Van der Eijk | Match Report | ||
| 24 | Fri | 2022-01-28 | 20:00 | Oss | 2–1 | Den Bosch | 1,520 | Frans Heesen Stadion | Alex Bos | Match Report | |
| 24 | Sat | 2022-01-29 | 16:30 | Excelsior | 0–1 | Emmen | 1,334 | Van Donge & De Roo Stadion | Richard Martens | Match Report | |
| 24 | Sat | 2022-01-29 | 18:45 | FC Eindhoven | 1–0 | MVV Maastricht | 1,400 | Jan Louwers Stadion | Martijn Vos | Match Report | |
| 24 | Sun | 2022-01-30 | 12:15 | VVV-Venlo | 4–2 | Dordrecht | 2,200 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 24 | Sun | 2022-01-30 | 14:30 | Almere City | 0–0 | Telstar | 1,523 | Yanmar Stadion | Michael Eijgelsheim | Match Report | |
| 24 | Sun | 2022-01-30 | 16:45 | ADO Den Haag | 0–0 | De Graafschap | 4,467 | Cars Jeans Stadion | Marc Nagtegaal | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Telstar | 0–3 | De Graafschap | 1,000 | BUKO Stadion | Ingmar Oostrom | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Jong PSV | 2–0 | Helmond Sport | 287 | Sportcomplex De Herdgang | Sam Dröge | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Dordrecht | 2–2 | Almere City | 1,150 | Riwal Hoogwerkers Stadion | Jesse Rozendal | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Volendam | 2–0 | Jong Utrecht | 2,166 | Kras Stadion | Clay Ruperti | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | MVV Maastricht | 0–5 | VVV-Venlo | 3,200 | De Geusselt | Erwin Blank | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Jong Ajax | 2–1 | Jong AZ | 473 | Sportpark De Toekomst | Robin Gansner | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | Emmen | 3–1 | Oss | 2,770 | De Oude Meerdijk | Robin Hensgens | Match Report | |
| 25 | Fri | 2022-02-04 | 20:00 | NAC Breda | 2–2 | Roda JC | 3,122 | Rat Verlegh Stadion | Luca Cantineau | Match Report | |
| 25 | Sun | 2022-02-06 | 12:15 | Den Bosch | 0–1 | ADO Den Haag | 1,698 | Sportpark De Vliert (BVV) | Laurens Gerrets | Match Report | |
| 24 | Mon | 2022-02-07 | 20:00 | Roda JC | 1–1 | Volendam | Parkstad Limburg Stadion | Richard Martens | Match Report | ||
| 24 | Mon | 2022-02-07 | 20:00 | Jong Ajax | 2–0 | Jong PSV | 480 | Sportpark De Toekomst | Michael Eijgelsheim | Match Report | |
| 24 | Mon | 2022-02-07 | 20:00 | Jong Utrecht | 3–2 | Helmond Sport | 140 | Sportcomplex Zoudenbalch | Luuk Timmer | Match Report | |
| 25 | Mon | 2022-02-07 | 20:00 | FC Eindhoven | 4–1 | Excelsior | 1,400 | Jan Louwers Stadion | Marc Nagtegaal | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Oss | 1–2 | FC Eindhoven | Frans Heesen Stadion | Sander Van der Eijk | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | Almere City | 0–0 | Emmen | Yanmar Stadion | Robin Gansner | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | ADO Den Haag | 2–3 | MVV Maastricht | Cars Jeans Stadion | Clay Ruperti | Match Report | ||
| 26 | Fri | 2022-02-11 | 20:00 | De Graafschap | 2–2 | Dordrecht | 3,742 | Stadion De Vijverberg | Joey Kooij | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Volendam | 2–1 | Jong AZ | 2,020 | Kras Stadion | Jannick van der Laan | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Helmond Sport | 2–2 | Telstar | 1,339 | SolarUnie Stadion | Jesse Rozendal | Match Report | |
| 26 | Fri | 2022-02-11 | 20:00 | Excelsior | 6–2 | Jong Ajax | 2,020 | Van Donge & De Roo Stadion | Robin Hensgens | Match Report | |
| 26 | Sun | 2022-02-13 | 12:15 | NAC Breda | 2–0 | Den Bosch | 6,314 | Rat Verlegh Stadion | Erwin Blank | Match Report | |
| 26 | Sun | 2022-02-13 | 14:30 | VVV-Venlo | 1–1 | Roda JC | Seacon Stadion De Koel | Jochem Kamphuis | Match Report | ||
| 26 | Mon | 2022-02-14 | 20:00 | Jong PSV | 0–2 | Jong Utrecht | Sportcomplex De Herdgang | R. Vereijken | Match Report | ||
| 24 | Mon | 2022-02-21 | 20:00 | Jong AZ | 0–2 | NAC Breda | AFAS Trainingscomplex | Luuk Timmer | Match Report | ||
| 27 | Mon | 2022-02-21 | 20:00 | Jong Utrecht | 0–1 | Excelsior | 263 | Sportcomplex Zoudenbalch | Jesse Rozendal | Match Report | |
| 27 | Mon | 2022-02-21 | 20:00 | Jong Ajax | 1–3 | Almere City | 728 | Sportpark De Toekomst | Luca Cantineau | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Excelsior | 2–0 | Roda JC | 3,130 | Van Donge & De Roo Stadion | Rob Dieperink | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Emmen | 2–1 | Jong Ajax | 7,303 | De Oude Meerdijk | Clay Ruperti | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Jong AZ | 1–3 | FC Eindhoven | 300 | AFAS Trainingscomplex | R. Vereijken | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | NAC Breda | 3–1 | Jong PSV | 10,024 | Rat Verlegh Stadion | Laurens Gerrets | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | De Graafschap | 0–0 | Den Bosch | 8,944 | Stadion De Vijverberg | Bas Nijhuis | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Oss | 4–1 | Jong Utrecht | 1,226 | Frans Heesen Stadion | Martijn Vos | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Almere City | 0–1 | VVV-Venlo | 2,467 | Yanmar Stadion | Marc Nagtegaal | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Volendam | 4–1 | Helmond Sport | 3,900 | Kras Stadion | Robin Hensgens | Match Report | |
| 28 | Fri | 2022-02-25 | 20:00 | Dordrecht | 3–1 | MVV Maastricht | 1,275 | Riwal Hoogwerkers Stadion | Richard Martens | Match Report | |
| 22 | Tue | 2022-03-01 | 20:00 | Emmen | 1–2 | Helmond Sport | De Oude Meerdijk | Alex Bos | Match Report | ||
| 29 | Fri | 2022-03-04 | 20:00 | MVV Maastricht | 1–2 | NAC Breda | 3,251 | De Geusselt | Martin Perez | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Helmond Sport | 1–2 | FC Eindhoven | 2,839 | SolarUnie Stadion | Erwin Blank | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | VVV-Venlo | 0–0 | Volendam | 5,100 | Seacon Stadion De Koel | Allard Lindhout | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | De Graafschap | 0–0 | Jong AZ | 8,869 | Stadion De Vijverberg | Martijn Vos | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Roda JC | 4–0 | Dordrecht | 5,123 | Parkstad Limburg Stadion | Alex Bos | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Excelsior | 4–0 | Den Bosch | 2,950 | Van Donge & De Roo Stadion | Ingmar Oostrom | Match Report | |
| 29 | Fri | 2022-03-04 | 20:00 | Telstar | 2–2 | Oss | 2,218 | BUKO Stadion | Clay Ruperti | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong Ajax | 6–3 | ADO Den Haag | 1,014 | Sportpark De Toekomst | Robin Gansner | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong Utrecht | 1–2 | Almere City | 1,014 | Sportcomplex Zoudenbalch | Sam Dröge | Match Report | |
| 29 | Mon | 2022-03-07 | 20:00 | Jong PSV | 1–3 | Emmen | 437 | Sportcomplex De Herdgang | Marc Nagtegaal | Match Report | |
| 30 | Mon | 2022-03-07 | 20:00 | Jong AZ | 3–2 | Telstar | 400 | AFAS Trainingscomplex | Luca Cantineau | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | NAC Breda | 2–0 | De Graafschap | 17,131 | Rat Verlegh Stadion | Jannick van der Laan | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Dordrecht | 3–3 | Jong Ajax | 2,054 | Riwal Hoogwerkers Stadion | R. Vereijken | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Den Bosch | 3–1 | MVV Maastricht | Sportpark De Vliert (BVV) | Robin Hensgens | Match Report | ||
| 30 | Fri | 2022-03-11 | 20:00 | Emmen | 2–0 | Jong Utrecht | 7,085 | De Oude Meerdijk | Rob Dieperink | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | FC Eindhoven | 4–0 | VVV-Venlo | 2,731 | Jan Louwers Stadion | Alex Bos | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Almere City | 3–0 | Helmond Sport | 2,381 | Yanmar Stadion | Martijn Vos | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Oss | 1–2 | Roda JC | 1,321 | Frans Heesen Stadion | Ingmar Oostrom | Match Report | |
| 30 | Fri | 2022-03-11 | 20:00 | Volendam | 2–5 | Excelsior | 5,012 | Kras Stadion | Marc Nagtegaal | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | MVV Maastricht | 2–3 | Jong AZ | De Geusselt | Alex Bos | Match Report | ||
| 27 | Mon | 2022-03-14 | 20:00 | Roda JC | 2–0 | De Graafschap | 9,350 | Parkstad Limburg Stadion | Martin Perez | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Den Bosch | 3–2 | Jong PSV | 2,382 | Sportpark De Vliert (BVV) | Robin Gansner | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Emmen | 4–1 | Volendam | 8,309 | De Oude Meerdijk | Edwin van de Graaf | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Helmond Sport | 0–3 | VVV-Venlo | 1,906 | SolarUnie Stadion | Laurens Gerrets | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | FC Eindhoven | 1–1 | ADO Den Haag | 3,111 | Jan Louwers Stadion | Joey Kooij | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Dordrecht | 1–0 | Oss | 1,015 | Riwal Hoogwerkers Stadion | Sam Dröge | Match Report | |
| 27 | Mon | 2022-03-14 | 20:00 | Telstar | 1–4 | NAC Breda | 2,268 | BUKO Stadion | Martijn Vos | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Almere City | 2–0 | Den Bosch | 2,406 | Yanmar Stadion | Clay Ruperti | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | ADO Den Haag | 1–1 | Volendam | 8,156 | Cars Jeans Stadion | Jeroen Manschot | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Telstar | 1–0 | Dordrecht | 1,823 | BUKO Stadion | Luuk Timmer | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Oss | 1–1 | Excelsior | 1,246 | Frans Heesen Stadion | Erwin Blank | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | De Graafschap | 1–3 | MVV Maastricht | 9,265 | Stadion De Vijverberg | Laurens Gerrets | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Helmond Sport | 4–0 | NAC Breda | 2,368 | SolarUnie Stadion | Marc Nagtegaal | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong Ajax | 2–2 | FC Eindhoven | 953 | Sportpark De Toekomst | Jannick van der Laan | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong PSV | 3–3 | Roda JC | 716 | Sportcomplex De Herdgang | Richard Martens | Match Report | |
| 31 | Fri | 2022-03-18 | 20:00 | Jong Utrecht | 0–1 | Jong AZ | 192 | Sportcomplex Zoudenbalch | Nick Smit | Match Report | |
| 31 | Sat | 2022-03-19 | 16:30 | VVV-Venlo | 0–2 | Emmen | 7,856 | Seacon Stadion De Koel | Martin Perez | Match Report | |
| 28 | Mon | 2022-03-21 | 20:00 | ADO Den Haag | 2–1 | Telstar | 4,123 | Cars Jeans Stadion | Robin Hensgens | Match Report | |
| 32 | Fri | 2022-03-25 | 21:00 | FC Eindhoven | 1–2 | De Graafschap | 2,802 | Jan Louwers Stadion | Sander van der Eijk | Match Report | |
| 32 | Fri | 2022-03-25 | 21:00 | Dordrecht | 3–1 | ADO Den Haag | 2,524 | Riwal Hoogwerkers Stadion | Martijn Vos | Match Report | |
| 32 | Sat | 2022-03-26 | 16:30 | Den Bosch | 0–0 | VVV-Venlo | 3,782 | Sportpark De Vliert (BVV) | R. Vereijken | Match Report | |
| 32 | Sat | 2022-03-26 | 18:45 | Excelsior | 3–0 | Helmond Sport | 3,345 | Van Donge & De Roo Stadion | Clay Ruperti | Match Report | |
| 32 | Sun | 2022-03-27 | 14:30 | MVV Maastricht | 0–3 | Almere City | 2,300 | De Geusselt | Robin Gansner | Match Report | |
| 32 | Sun | 2022-03-27 | 16:45 | Emmen | 2–1 | Telstar | 7,704 | De Oude Meerdijk | Sam Dröge | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | De Graafschap | 1–1 | Emmen | 14,022 | Stadion De Vijverberg | Jochem Kamphuis | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | VVV-Venlo | 0–5 | ADO Den Haag | 5,259 | Seacon Stadion De Koel | Rob Dieperink | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Roda JC | 2–1 | Jong Utrecht | 4,523 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Dordrecht | 0–1 | FC Eindhoven | 1,557 | Riwal Hoogwerkers Stadion | Laurens Gerrets | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Telstar | 1–2 | Den Bosch | 1,435 | BUKO Stadion | Martin Perez | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Helmond Sport | 1–2 | MVV Maastricht | 2,344 | SolarUnie Stadion | Nick Smit | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Almere City | 3–0 | Excelsior | 2,847 | Yanmar Stadion | Dennis Higler | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Jong AZ | 2–0 | Jong PSV | 250 | AFAS Trainingscomplex | Luuk Timmer | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | Volendam | 1–2 | Oss | 4,418 | Kras Stadion | Joey Kooij | Match Report | |
| 33 | Fri | 2022-04-01 | 20:00 | NAC Breda | 0–0 | Jong Ajax | 17,231 | Rat Verlegh Stadion | Erwin Blank | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong AZ | 0–1 | Roda JC | 337 | AFAS Trainingscomplex | Clay Ruperti | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong Utrecht | 1–0 | NAC Breda | 583 | Sportcomplex Zoudenbalch | Robin Hensgens | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong PSV | 2–2 | Volendam | 367 | Sportcomplex De Herdgang | Alex Bos | Match Report | |
| 32 | Mon | 2022-04-04 | 20:00 | Jong Ajax | 4–1 | Oss | 888 | Sportpark De Toekomst | Martijn Vos | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Emmen | 3–0 | Jong AZ | 8,155 | De Oude Meerdijk | Ingmar Oostrom | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Den Bosch | 3–0 | Dordrecht | 3,287 | Sportpark De Vliert (BVV) | Nick Smit | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Excelsior | 1–4 | Telstar | 3,063 | Van Donge & De Roo Stadion | Alex Bos | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | FC Eindhoven | 3–1 | Almere City | 2,236 | Jan Louwers Stadion | Richard Martens | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Roda JC | 2–2 | Jong Ajax | 13,001 | Parkstad Limburg Stadion | Robin Gansner | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Volendam | 3–1 | De Graafschap | 5,859 | Kras Stadion | Martin van den Kerkhof | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | Oss | 2–0 | Jong PSV | 1,164 | Frans Heesen Stadion | R. Vereijken | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | MVV Maastricht | 2–4 | Jong Utrecht | 2,000 | De Geusselt | Sam Dröge | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | ADO Den Haag | 2–1 | Helmond Sport | 5,743 | Cars Jeans Stadion | Jannick van der Laan | Match Report | |
| 34 | Fri | 2022-04-08 | 20:00 | NAC Breda | 3–1 | VVV-Venlo | 16,632 | Rat Verlegh Stadion | Joey Kooij | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Jong AZ | 0–1 | ADO Den Haag | 475 | AFAS Trainingscomplex | Robin Gansner | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Dordrecht | 0–1 | Emmen | 3,315 | Riwal Hoogwerkers Stadion | Erwin Blank | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | VVV-Venlo | 3–2 | Telstar | 5,562 | Seacon Stadion De Koel | Michael Eijgelsheim | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | De Graafschap | 1–2 | Oss | 10,084 | Stadion De Vijverberg | Marc Nagtegaal | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | FC Eindhoven | 1–3 | Jong PSV | 4,031 | Jan Louwers Stadion | Martin Perez | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | MVV Maastricht | 1–1 | Excelsior | 2,112 | De Geusselt | Robin Hensgens | Match Report | |
| 35 | Fri | 2022-04-15 | 20:00 | Roda JC | 5–3 | Helmond Sport | 8,427 | Parkstad Limburg Stadion | Laurens Gerrets | Match Report | |
| 35 | Sat | 2022-04-16 | 16:30 | Volendam | 3–1 | Jong Ajax | 6,500 | Kras Stadion | Sander van der Eijk | Match Report | |
| 35 | Sat | 2022-04-16 | 21:00 | Almere City | 1–2 | NAC Breda | 3,160 | Yanmar Stadion | Rob Dieperink | Match Report | |
| 35 | Mon | 2022-04-18 | 20:00 | Jong Utrecht | 0–1 | Den Bosch | 406 | Sportcomplex Zoudenbalch | Luuk Timmer | Match Report | |
| 30 | Tue | 2022-04-19 | 20:00 | ADO Den Haag | 2–2 | Jong PSV | 3,724 | Cars Jeans Stadion | Clay Ruperti | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Oss | 2–3 | Almere City | 1,583 | Frans Heesen Stadion | Martin Perez | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Telstar | 0–1 | FC Eindhoven | 2,746 | BUKO Stadion | Martijn Vos | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | NAC Breda | 1–2 | Dordrecht | 16,576 | Rat Verlegh Stadion | Alex Bos | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Emmen | 2–0 | Roda JC | 8,309 | De Oude Meerdijk | Pol van Boekel | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Helmond Sport | 0–4 | De Graafschap | 2,319 | SolarUnie Stadion | Richard Martens | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Excelsior | 3–3 | Jong AZ | 2,934 | Van Donge & De Roo Stadion | Sam Dröge | Match Report | |
| 36 | Fri | 2022-04-22 | 20:00 | Den Bosch | 1–2 | Volendam | 5,328 | Sportpark De Vliert (BVV) | Jannick van der Laan | Match Report | |
| 36 | Sun | 2022-04-24 | 12:15 | ADO Den Haag | 1–1 | Jong Utrecht | 6,338 | Cars Jeans Stadion | Ingmar Oostrom | Match Report | |
| 36 | Mon | 2022-04-25 | 20:00 | Jong PSV | 2–2 | MVV Maastricht | 648 | Sportcomplex De Herdgang | Michael Eijgelsheim | Match Report | |
| 36 | Mon | 2022-04-25 | 20:00 | Jong Ajax | 6–1 | VVV-Venlo | 1,247 | Sportpark De Toekomst | Nick Smit | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | ADO Den Haag | 1–0 | Almere City | Cars Jeans Stadion | Alex Bos | Match Report | ||
| 37 | Fri | 2022-04-29 | 20:00 | FC Eindhoven | 1–0 | Emmen | 3,706 | Jan Louwers Stadion | Joey Kooij | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Dordrecht | 3–2 | Volendam | 2,022 | Riwal Hoogwerkers Stadion | Robin Hensgens | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | De Graafschap | 1–1 | Jong PSV | Stadion De Vijverberg | Robin Gansner | Match Report | ||
| 37 | Fri | 2022-04-29 | 20:00 | VVV-Venlo | 2–2 | Excelsior | 6,223 | Seacon Stadion De Koel | Martijn Vos | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | NAC Breda | 3–0 | Oss | 15,814 | Rat Verlegh Stadion | Clay Ruperti | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Jong AZ | 0–1 | Helmond Sport | 280 | AFAS Trainingscomplex | Luca Cantineau | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | MVV Maastricht | 1–0 | Jong Ajax | 3,856 | De Geusselt | R. Vereijken | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Den Bosch | 1–0 | Roda JC | 4,869 | Sportpark De Vliert (BVV) | Erwin Blank | Match Report | |
| 37 | Fri | 2022-04-29 | 20:00 | Telstar | 1–3 | Jong Utrecht | BUKO Stadion | Jesse Rozendal | Match Report | ||
| 38 | Fri | 2022-05-06 | 20:00 | Helmond Sport | 1–1 | Den Bosch | 3,643 | SolarUnie Stadion | Sam Dröge | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Roda JC | 4–3 | Telstar | 8,487 | Parkstad Limburg Stadion | Jannick van der Laan | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Excelsior | 2–2 | NAC Breda | 3,744 | Van Donge & De Roo Stadion | Luca Cantineau | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Oss | 0–1 | MVV Maastricht | 2,198 | Frans Heesen Stadion | Jesse Rozendal | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong PSV | 1–1 | Dordrecht | 783 | Sportcomplex De Herdgang | Luuk Timmer | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Almere City | 0–3 | Jong AZ | 3,028 | Yanmar Stadion | Erwin Blank | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Emmen | 3–0 | ADO Den Haag | 8,205 | De Oude Meerdijk | Sander van der Eijk | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Volendam | 2–2 | FC Eindhoven | 5,818 | Kras Stadion | Rob Dieperink | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong Utrecht | 2–3 | VVV-Venlo | 402 | Sportcomplex Zoudenbalch | Laurens Gerrets | Match Report | |
| 38 | Fri | 2022-05-06 | 20:00 | Jong Ajax | 1–1 | De Graafschap | 1,358 | Sportpark De Toekomst | Martin Perez | Match Report |
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