Scores & Fixtures 2021 Chilean Primera División
| Wk | Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sat | 2021-03-27 | 11:00 | Curico Unido | 2–0 | Deportes Melipilla | Estadio Bicentenario La Granja | Juan Lara | Match Report | ||
| 1 | Sat | 2021-03-27 | 16:00 | Everton | 1–1 | O'Higgins | Estadio Sausalito | Nicolás Gamboa | Match Report | ||
| 1 | Sat | 2021-03-27 | 18:30 | Colo-Colo | 0–0 | La Calera | Estadio Monumental David Arellano | Julio Bascuñán | Match Report | ||
| 1 | Sun | 2021-03-28 | 10:45 | Palestino | 2–4 | Antofagasta | Estadio Municipal de La Cisterna | Piero Maza | Match Report | ||
| 1 | Sun | 2021-03-28 | 17:00 | Huachipato | 0–0 | Cobresal | Estadio CAP | Benjamín Saravia | Match Report | ||
| 1 | Sun | 2021-03-28 | 19:30 | Ñublense | 0–1 | Univ Católica | Estadio Bicentenario Municipal Nelson Oy... | Rodrigo Carvajal | Match Report | ||
| 1 | Sat | 2021-03-27 | 21:00 | Unión Española | 3–1 | Wanderers | Estadio Santa Laura-Universidad SEK | Angelo Hermosilla | Match Report | ||
| 1 | Tue | 2021-03-30 | 20:00 | Audax Italiano | 2–1 | La Serena | Estadio CODELCO-El Teniente | Eduardo Gamboa Latourniere | Match Report | ||
| 2 | Fri | 2021-04-02 | 16:00 | Antofagasta | 1–2 | Everton | Estadio Regional Calvo y Bascuñán | Cristián Droguett | Match Report | ||
| 2 | Fri | 2021-04-02 | 19:00 | La Calera | 1–0 | Unión Española | Estadio Municipal Nicolás Chahuán Nazar | Felipe González | Match Report | ||
| 2 | Sat | 2021-04-03 | 11:00 | Deportes Melipilla | 1–1 | Ñublense | Estadio Municipal de La Pintana | Manuel Vergara | Match Report | ||
| 2 | Sat | 2021-04-03 | 18:00 | U de Chile | 1–1 | Huachipato | Estadio CODELCO-El Teniente | Cristián Garay | Match Report | ||
| 2 | Sat | 2021-04-03 | 20:30 | Cobresal | 1–2 | Colo-Colo | Estadio El Cobre | Cesar Deischler | Match Report | ||
| 2 | Sun | 2021-04-04 | 17:00 | La Serena | 2–0 | Curico Unido | Estadio La Portada | Christian Rojas | Match Report | ||
| 2 | Sun | 2021-04-04 | 19:15 | Univ Católica | 2–1 | Palestino | Estadio San Carlos de Apoquindo | Fernando Vejar | Match Report | ||
| 2 | Sun | 2021-04-04 | 21:30 | O'Higgins | 0–0 | Audax Italiano | Estadio CODELCO-El Teniente | Héctor Jona | Match Report | ||
| 3 | Sat | 2021-04-10 | 16:00 | Unión Española | 0–2 | Deportes Melipilla | Estadio Santa Laura-Universidad SEK | José Cabero | Match Report | ||
| 3 | Sat | 2021-04-10 | 18:30 | Audax Italiano | 1–0 | Univ Católica | Estadio CODELCO-El Teniente | Julio Bascuñán | Match Report | ||
| 3 | Sun | 2021-04-11 | 17:30 | Wanderers | 1–2 | La Calera | Estadio Elías Figueroa Brander | Eduardo Gamboa Latourniere | Match Report | ||
| 3 | Sun | 2021-04-11 | 21:00 | La Serena | 0–0 | U de Chile | Estadio Romero Cuerda | Angelo Hermosilla | Match Report | ||
| 3 | Mon | 2021-04-12 | 12:00 | Ñublense | 3–1 | Cobresal | Estadio Bicentenario Municipal Nelson Oy... | Gustavo Ahumada | Match Report | ||
| 3 | Mon | 2021-04-12 | 15:00 | Palestino | 1–1 | Everton | Estadio Municipal de La Cisterna | Francisco Gilabert | Match Report | ||
| 3 | Mon | 2021-04-12 | 17:15 | Curico Unido | 1–1 | Antofagasta | Estadio Bicentenario La Granja | Matías Quila | Match Report | ||
| 3 | Sun | 2021-04-11 | 20:00 | Colo-Colo | 1–2 | O'Higgins | Estadio Monumental David Arellano | Rodrigo Carvajal | Match Report | ||
| 4 | Fri | 2021-04-16 | 15:30 | Deportes Melipilla | 0–1 | Palestino | Estadio Municipal de La Pintana | Christian Rojas | Match Report | ||
| 4 | Fri | 2021-04-16 | 18:00 | Huachipato | 5–3 | Ñublense | Estadio CAP | Francisco Gilabert | Match Report | ||
| 4 | Sat | 2021-04-17 | 18:00 | O'Higgins | 0–0 | La Serena | Estadio CODELCO-El Teniente | Cesar Deischler | Match Report | ||
| 4 | Fri | 2021-04-16 | 20:30 | Univ Católica | 2–1 | Curico Unido | Estadio San Carlos de Apoquindo | José Cabero | Match Report | ||
| 4 | Sun | 2021-04-18 | 11:00 | Cobresal | 2–1 | Wanderers | Estadio El Cobre | Cristián Droguett | Match Report | ||
| 4 | Sun | 2021-04-18 | 15:00 | Everton | 0–2 | Colo-Colo | Estadio Sausalito | Juan Lara | Match Report | ||
| 4 | Sat | 2021-04-17 | 20:30 | La Calera | 1–1 | Audax Italiano | Estadio Municipal Nicolás Chahuán Nazar | Benjamín Saravia | Match Report | ||
| 4 | Mon | 2021-04-19 | 20:30 | U de Chile | 2–1 | Unión Española | Estadio Nacional Julio Martínez Prádanos | Fernando Vejar | Match Report | ||
| 5 | Sat | 2021-04-24 | 12:00 | Antofagasta | 2–1 | Cobresal | Estadio Regional Calvo y Bascuñán | Manuel Vergara | Match Report | ||
| 5 | Sat | 2021-04-24 | 15:30 | La Serena | 0–0 | Unión Española | Estadio La Portada | Héctor Jona | Match Report | ||
| 5 | Sat | 2021-04-24 | 18:00 | O'Higgins | 1–0 | La Calera | Estadio CODELCO-El Teniente | Juan Lara | Match Report | ||
| 5 | Fri | 2021-04-23 | 20:00 | Curico Unido | 1–1 | Everton | Estadio Bicentenario La Granja | Benjamín Saravia | Match Report | ||
| 5 | Sun | 2021-04-25 | 16:00 | Colo-Colo | 1–0 | U de Chile | Estadio Monumental David Arellano | Julio Bascuñán | Match Report | ||
| 5 | Sat | 2021-04-24 | 20:30 | Wanderers | 1–2 | Ñublense | Estadio Elías Figueroa Brander | Rodrigo Carvajal | Match Report | ||
| 5 | Mon | 2021-04-26 | 20:30 | Audax Italiano | 1–0 | Deportes Melipilla | Estadio CODELCO-El Teniente | Matías Quila | Match Report | ||
| 6 | Sat | 2021-05-01 | 12:30 | La Calera | 2–1 | Antofagasta | Estadio Municipal Nicolás Chahuán Nazar | Cesar Deischler | Match Report | ||
| 6 | Sat | 2021-05-01 | 15:30 | Unión Española | 1–1 | Audax Italiano | Estadio Santa Laura-Universidad SEK | Christian Rojas | Match Report | ||
| 6 | Sat | 2021-05-01 | 18:00 | Ñublense | 5–1 | Colo-Colo | Estadio Bicentenario Municipal Nelson Oy... | José Cabero | Match Report | ||
| 6 | Fri | 2021-04-30 | 20:00 | Everton | 0–4 | La Serena | Estadio Sausalito | Gustavo Ahumada | Match Report | ||
| 6 | Sun | 2021-05-02 | 11:00 | Cobresal | 2–0 | Curico Unido | Estadio El Cobre | Fernando Vejar | Match Report | ||
| 6 | Sun | 2021-05-02 | 15:30 | Huachipato | 0–1 | O'Higgins | Estadio CAP | Cristián Droguett | Match Report | ||
| 6 | Sun | 2021-05-02 | 18:00 | Deportes Melipilla | 2–0 | Univ Católica | Estadio Municipal Nicolás Chahuán Nazar | Julio Bascuñán | Match Report | ||
| 6 | Mon | 2021-05-03 | 20:30 | U de Chile | 1–0 | Wanderers | Estadio CODELCO-El Teniente | Juan Lara | Match Report | ||
| 7 | Sat | 2021-05-08 | 12:00 | Univ Católica | 3–0 | La Calera | Estadio San Carlos de Apoquindo | Christian Rojas | Match Report | ||
| 7 | Sat | 2021-05-08 | 15:30 | La Serena | 1–0 | Ñublense | Estadio La Portada | Matías Quila | Match Report | ||
| 7 | Sat | 2021-05-08 | 18:00 | Wanderers | 0–3 | Deportes Melipilla | Estadio Elías Figueroa Brander | Francisco Gilabert | Match Report | ||
| 7 | Fri | 2021-05-07 | 20:00 | O'Higgins | 1–4 | Unión Española | Estadio CODELCO-El Teniente | Manuel Vergara | Match Report | ||
| 7 | Sun | 2021-05-09 | 12:00 | Curico Unido | 2–2 | Huachipato | Estadio Bicentenario La Granja | José Cabero | Match Report | ||
| 7 | Sun | 2021-05-09 | 15:30 | Antofagasta | 1–2 | U de Chile | Estadio Regional Calvo y Bascuñán | Rodrigo Carvajal | Match Report | ||
| 7 | Sun | 2021-05-09 | 18:00 | Audax Italiano | 0–0 | Cobresal | Estadio CODELCO-El Teniente | Felipe González | Match Report | ||
| 7 | Sat | 2021-05-08 | 20:30 | Colo-Colo | 1–2 | Palestino | Estadio Monumental David Arellano | Fernando Vejar | Match Report | ||
| 8 | Sat | 2021-05-22 | 11:00 | Cobresal | 2–0 | La Serena | Estadio El Cobre | Cristián Droguett | Match Report | ||
| 8 | Sat | 2021-05-22 | 15:30 | Ñublense | 2–0 | Curico Unido | Estadio Bicentenario Municipal Nelson Oy... | Héctor Jona | Match Report | ||
| 8 | Sat | 2021-05-22 | 18:00 | Wanderers | 0–0 | O'Higgins | Estadio Elías Figueroa Brander | Julio Bascuñán | Match Report | ||
| 8 | Sun | 2021-05-23 | 12:30 | Deportes Melipilla | 1–1 | Antofagasta | Estadio Municipal de La Pintana | José Cabero | Match Report | ||
| 8 | Sun | 2021-05-23 | 15:00 | Huachipato | 0–2 | Colo-Colo | Estadio CAP | Eduardo Gamboa Latourniere | Match Report | ||
| 8 | Sat | 2021-05-22 | 20:30 | Unión Española | 3–2 | Univ Católica | Estadio Santa Laura-Universidad SEK | Cristián Garay | Match Report | ||
| 8 | Sun | 2021-05-23 | 20:30 | U de Chile | 0–1 | Everton | Estadio CODELCO-El Teniente | Francisco Gilabert | Match Report | ||
| 9 | Sat | 2021-05-29 | 15:00 | La Serena | 5–1 | Deportes Melipilla | Estadio La Portada | Matías Quila | Match Report | ||
| 9 | Sat | 2021-05-29 | 17:30 | O'Higgins | 1–0 | Palestino | Estadio CODELCO-El Teniente | Matías Quila | Match Report | ||
| 9 | Fri | 2021-05-28 | 20:00 | Curico Unido | 1–2 | Unión Española | Estadio Bicentenario La Granja | Cristián Droguett | Match Report | ||
| 9 | Sun | 2021-05-30 | 16:00 | Everton | 1–0 | Wanderers | Estadio Sausalito | Felipe González | Match Report | ||
| 9 | Sun | 2021-05-30 | 19:00 | Univ Católica | 2–1 | Cobresal | Estadio San Carlos de Apoquindo | Cesar Deischler | Match Report | ||
| 9 | Mon | 2021-05-31 | 15:30 | Antofagasta | 1–0 | Huachipato | Estadio Regional Calvo y Bascuñán | Christian Rojas | Match Report | ||
| 9 | Mon | 2021-05-31 | 18:00 | La Calera | 1–0 | Ñublense | Estadio Municipal Nicolás Chahuán Nazar | Rodrigo Carvajal | Match Report | ||
| 9 | Mon | 2021-05-31 | 20:30 | Audax Italiano | 2–1 | U de Chile | Estadio CODELCO-El Teniente | Eduardo Gamboa Latourniere | Match Report | ||
| 10 | Sat | 2021-06-05 | 10:30 | Cobresal | 0–1 | La Calera | Estadio El Cobre | Eduardo Gamboa Latourniere | Match Report | ||
| 10 | Sat | 2021-06-05 | 13:00 | Wanderers | 0–1 | Univ Católica | Estadio Elías Figueroa Brander | Christian Rojas | Match Report | ||
| 10 | Sat | 2021-06-05 | 15:30 | Palestino | 0–0 | U de Chile | Estadio Municipal de La Cisterna | Felipe González | Match Report | ||
| 10 | Sun | 2021-06-06 | 11:30 | Unión Española | 1–1 | Antofagasta | Estadio Santa Laura-Universidad SEK | Francisco Gilabert | Match Report | ||
| 10 | Sun | 2021-06-06 | 18:00 | Colo-Colo | 2–0 | La Serena | Estadio Monumental David Arellano | José Cabero | Match Report | ||
| 10 | Sat | 2021-06-05 | 20:30 | Huachipato | 0–0 | Everton | Estadio CAP | Héctor Jona | Match Report | ||
| 10 | Sun | 2021-06-06 | 20:30 | Deportes Melipilla | 3–1 | O'Higgins | Estadio Municipal de La Pintana | Gustavo Ahumada | Match Report | ||
| 10 | Mon | 2021-06-07 | 20:30 | Ñublense | 1–0 | Audax Italiano | Estadio Bicentenario Municipal Nelson Oy... | Cristián Droguett | Match Report | ||
| 8 | Tue | 2021-06-15 | 12:30 | Palestino | 0–2 | Audax Italiano | Estadio Municipal de La Cisterna | Christian Rojas | Match Report | ||
| 5 | Thu | 2021-07-15 | 12:30 | Palestino | 2–0 | Huachipato | Estadio Municipal de La Cisterna | Gustavo Ahumada | Match Report | ||
| 11 | Fri | 2021-07-16 | 12:30 | Antofagasta | 1–0 | Wanderers | Estadio Regional Calvo y Bascuñán | Cristián Droguett | Match Report | ||
| 11 | Thu | 2021-07-15 | 20:00 | O'Higgins | 1–1 | Cobresal | Estadio CODELCO-El Teniente | Fernando Vejar | Match Report | ||
| 11 | Sat | 2021-07-17 | 16:00 | Univ Católica | 0–0 | Colo-Colo | Estadio San Carlos de Apoquindo | José Cabero | Match Report | ||
| 11 | Fri | 2021-07-16 | 20:30 | La Calera | 1–0 | Curico Unido | Estadio Municipal Nicolás Chahuán Nazar | Manuel Vergara | Match Report | ||
| 11 | Mon | 2021-07-19 | 18:00 | Audax Italiano | 3–3 | Huachipato | Estadio CODELCO-El Teniente | Matías Quila | Match Report | ||
| 11 | Tue | 2021-07-20 | 15:00 | La Serena | 4–3 | Palestino | Estadio La Portada | Francisco Gilabert | Match Report | ||
| 11 | Mon | 2021-07-19 | 20:30 | Everton | 0–0 | Ñublense | Estadio Sausalito | Benjamín Saravia | Match Report | ||
| 11 | Tue | 2021-07-20 | 20:30 | U de Chile | 2–0 | Deportes Melipilla | Estadio CODELCO-El Teniente | Christian Rojas | Match Report | ||
| 12 | Sat | 2021-07-24 | 15:00 | Ñublense | 0–0 | Antofagasta | Estadio Bicentenario Municipal Nelson Oy... | Francisco Gilabert | Match Report | ||
| 12 | Sat | 2021-07-24 | 17:30 | Deportes Melipilla | 3–3 | La Calera | Estadio Municipal de La Pintana | Cesar Deischler | Match Report | ||
| 12 | Fri | 2021-07-23 | 20:30 | Everton | 2–0 | Unión Española | Estadio Sausalito | Héctor Jona | Match Report | ||
| 12 | Sun | 2021-07-25 | 12:30 | Huachipato | 0–0 | La Serena | Estadio CAP | Manuel Vergara | Match Report | ||
| 12 | Sun | 2021-07-25 | 15:00 | Palestino | 2–0 | Wanderers | Estadio Municipal de La Cisterna | Benjamín Saravia | Match Report | ||
| 12 | Sun | 2021-07-25 | 17:30 | Curico Unido | 1–2 | U de Chile | Estadio Bicentenario La Granja | Gustavo Ahumada | Match Report | ||
| 12 | Sat | 2021-07-24 | 20:00 | Colo-Colo | 1–1 | Audax Italiano | Estadio Monumental David Arellano | Rodrigo Carvajal | Match Report | ||
| 12 | Sun | 2021-07-25 | 20:00 | Univ Católica | 3–0 | O'Higgins | Estadio San Carlos de Apoquindo | Cristián Droguett | Match Report | ||
| 13 | Tue | 2021-07-27 | 19:00 | Audax Italiano | 0–2 | Everton | Estadio CODELCO-El Teniente | Angelo Hermosilla | Match Report | ||
| 13 | Wed | 2021-07-28 | 11:00 | Cobresal | 1–1 | Deportes Melipilla | Estadio El Cobre | Cristián Droguett | Match Report | ||
| 13 | Wed | 2021-07-28 | 15:30 | Unión Española | 3–1 | Huachipato | Estadio Santa Laura-Universidad SEK | Christian Rojas | Match Report | ||
| 13 | Wed | 2021-07-28 | 18:00 | O'Higgins | 2–2 | Curico Unido | Estadio CODELCO-El Teniente | José Cabero | Match Report | ||
| 13 | Thu | 2021-07-29 | 12:30 | Antofagasta | 3–2 | Univ Católica | Estadio Regional Calvo y Bascuñán | Héctor Jona | Match Report | ||
| 13 | Thu | 2021-07-29 | 15:00 | Wanderers | 0–4 | Colo-Colo | Estadio Elías Figueroa Brander | Felipe González | Match Report | ||
| 13 | Thu | 2021-07-29 | 19:00 | U de Chile | 1–1 | Ñublense | Estadio CODELCO-El Teniente | Nicolás Gamboa | Match Report | ||
| 13 | Wed | 2021-07-28 | 20:30 | La Calera | 2–1 | Palestino | Estadio Municipal Nicolás Chahuán Nazar | Fernando Vejar | Match Report | ||
| 14 | Sun | 2021-08-01 | 11:00 | Huachipato | 0–0 | La Calera | Estadio CAP | Gustavo Ahumada | Match Report | ||
| 14 | Sun | 2021-08-01 | 13:30 | Palestino | 3–2 | Unión Española | Estadio Municipal de La Cisterna | Nicolás Gamboa | Match Report | ||
| 14 | Sun | 2021-08-01 | 16:00 | U de Chile | 2–1 | Univ Católica | Estadio CODELCO-El Teniente | Roberto Tobar | Match Report | ||
| 14 | Mon | 2021-08-02 | 14:30 | La Serena | 1–1 | Antofagasta | Estadio La Portada | Eduardo Gamboa Latourniere | Match Report | ||
| 14 | Mon | 2021-08-02 | 18:00 | Ñublense | 0–0 | O'Higgins | Estadio Bicentenario Municipal Nelson Oy... | Felipe González Alveal | Match Report | ||
| 14 | Sun | 2021-08-01 | 20:00 | Deportes Melipilla | 2–4 | Colo-Colo | Estadio Municipal Nicolás Chahuán Nazar | Piero Maza | Match Report | ||
| 14 | Mon | 2021-08-02 | 20:30 | Curico Unido | 2–1 | Wanderers | Estadio Bicentenario La Granja | Angelo Hermosilla | Match Report | ||
| 14 | Tue | 2021-08-03 | 20:30 | Everton | 3–0 | Cobresal | Estadio Sausalito | Julio Bascuñán | Match Report | ||
| 15 | Sat | 2021-08-07 | 15:00 | O'Higgins | 1–3 | U de Chile | Estadio CODELCO-El Teniente | Julio Bascuñán | Match Report | ||
| 15 | Sat | 2021-08-07 | 17:30 | Unión Española | 3–2 | Ñublense | Estadio Santa Laura-Universidad SEK | Matías Quila | Match Report | ||
| 15 | Sun | 2021-08-08 | 12:30 | Wanderers | 1–4 | Huachipato | Estadio Elías Figueroa Brander | Fernando Vejar | Match Report | ||
| 15 | Sun | 2021-08-08 | 15:00 | Antofagasta | 0–1 | Audax Italiano | Estadio Regional Calvo y Bascuñán | Roberto Tobar | Match Report | ||
| 15 | Sun | 2021-08-08 | 17:30 | Colo-Colo | 2–0 | Curico Unido | Estadio Monumental David Arellano | Cristián Droguett | Match Report | ||
| 15 | Sat | 2021-08-07 | 20:00 | Univ Católica | 4–3 | La Serena | Estadio San Carlos de Apoquindo | Felipe González | Match Report | ||
| 15 | Mon | 2021-08-09 | 11:00 | Cobresal | 3–1 | Palestino | Estadio El Cobre | Juan Lara | Match Report | ||
| 15 | Sun | 2021-08-08 | 20:00 | La Calera | 1–0 | Everton | Estadio Municipal Nicolás Chahuán Nazar | Piero Maza | Match Report | ||
| 16 | Fri | 2021-08-13 | 19:00 | Audax Italiano | 1–0 | Wanderers | Estadio CODELCO-El Teniente | Eduardo Gamboa Latourniere | Match Report | ||
| 16 | Sat | 2021-08-14 | 11:30 | Antofagasta | 2–1 | O'Higgins | Estadio Regional Calvo y Bascuñán | Benjamín Saravia | Match Report | ||
| 16 | Sat | 2021-08-14 | 14:00 | La Serena | 1–2 | La Calera | Estadio La Portada | Cesar Deischler | Match Report | ||
| 16 | Sat | 2021-08-14 | 16:30 | Unión Española | 0–1 | Colo-Colo | Estadio Santa Laura-Universidad SEK | Gustavo Ahumada | Match Report | ||
| 16 | Sat | 2021-08-14 | 19:00 | Everton | 1–2 | Deportes Melipilla | Estadio Sausalito | Rodrigo Carvajal | Match Report | ||
| 16 | Sun | 2021-08-15 | 14:00 | Palestino | 0–2 | Curico Unido | Estadio Municipal de La Cisterna | Roberto Tobar | Match Report | ||
| 16 | Sun | 2021-08-15 | 16:30 | U de Chile | 0–2 | Cobresal | Estadio CODELCO-El Teniente | Piero Maza | Match Report | ||
| 16 | Sun | 2021-08-15 | 19:00 | Huachipato | 2–1 | Univ Católica | Estadio CAP | Manuel Vergara | Match Report | ||
| 17 | Sat | 2021-08-21 | 11:30 | Wanderers | 2–2 | La Serena | Estadio Elías Figueroa Brander | Rodrigo Carvajal | Match Report | ||
| 17 | Sat | 2021-08-21 | 14:00 | Ñublense | 2–2 | Palestino | Estadio Bicentenario Municipal Nelson Oy... | Francisco Gilabert | Match Report | ||
| 17 | Sat | 2021-08-21 | 16:30 | Colo-Colo | 2–0 | Antofagasta | Estadio Monumental David Arellano | Héctor Jona | Match Report | ||
| 17 | Sat | 2021-08-21 | 19:00 | Curico Unido | 2–2 | Audax Italiano | Estadio Bicentenario La Granja | José Cabero | Match Report | ||
| 17 | Sun | 2021-08-22 | 11:00 | Cobresal | 2–0 | Unión Española | Estadio El Cobre | Benjamín Saravia | Match Report | ||
| 17 | Sun | 2021-08-22 | 14:00 | Deportes Melipilla | 1–2 | Huachipato | Estadio Municipal de La Pintana | Christian Rojas | Match Report | ||
| 17 | Sun | 2021-08-22 | 16:30 | La Calera | 1–4 | U de Chile | Estadio Municipal Nicolás Chahuán Nazar | Cristián Droguett | Match Report | ||
| 17 | Sun | 2021-08-22 | 19:00 | Univ Católica | 2–0 | Everton | Estadio San Carlos de Apoquindo | Nicolás Gamboa | Match Report | ||
| 18 | Wed | 2021-08-25 | 11:30 | Deportes Melipilla | 1–1 | Curico Unido | Estadio Municipal de La Pintana | Juan Lara | Match Report | ||
| 18 | Wed | 2021-08-25 | 14:00 | Antofagasta | 2–1 | Palestino | Estadio Regional Calvo y Bascuñán | Manuel Vergara | Match Report | ||
| 18 | Wed | 2021-08-25 | 16:30 | La Calera | 1–1 | Colo-Colo | Estadio Municipal Nicolás Chahuán Nazar | Julio Bascuñán | Match Report | ||
| 18 | Wed | 2021-08-25 | 19:00 | Univ Católica | 2–2 | Ñublense | Estadio San Carlos de Apoquindo | Héctor Jona | Match Report | ||
| 18 | Thu | 2021-08-26 | 14:00 | La Serena | 0–2 | Audax Italiano | Estadio La Portada | Matías Quila | Match Report | ||
| 18 | Thu | 2021-08-26 | 16:30 | Wanderers | 1–2 | Unión Española | Estadio Elías Figueroa Brander | Cristián Garay | Match Report | ||
| 18 | Thu | 2021-08-26 | 19:00 | O'Higgins | 1–0 | Everton | Estadio CODELCO-El Teniente | Cesar Deischler | Match Report | ||
| 19 | Sat | 2021-08-28 | 15:00 | Palestino | 3–0 | Univ Católica | Estadio Municipal de La Cisterna | Piero Maza | Match Report | ||
| 19 | Sun | 2021-08-29 | 11:30 | Everton | 1–1 | Antofagasta | Estadio Sausalito | Fernando Vejar | Match Report | ||
| 19 | Sun | 2021-08-29 | 14:00 | Huachipato | 1–1 | U de Chile | Estadio CAP | Julio Bascuñán | Match Report | ||
| 19 | Sun | 2021-08-29 | 16:30 | Colo-Colo | 0–1 | Cobresal | Estadio Monumental David Arellano | Cristián Garay | Match Report | ||
| 19 | Sun | 2021-08-29 | 19:00 | Unión Española | 2–1 | La Calera | Estadio Santa Laura-Universidad SEK | Eduardo Gamboa Latourniere | Match Report | ||
| 19 | Sat | 2021-08-28 | 20:00 | Ñublense | 3–0 | Deportes Melipilla | Estadio Bicentenario Municipal Nelson Oy... | Angelo Hermosilla | Match Report | ||
| 19 | Mon | 2021-08-30 | 18:30 | Audax Italiano | 1–0 | O'Higgins | Estadio Municipal de La Pintana | Nicolás Gamboa | Match Report | ||
| 19 | Mon | 2021-08-30 | 21:00 | Curico Unido | 2–0 | La Serena | Estadio Bicentenario La Granja | Benjamín Saravia | Match Report | ||
| 20 | Mon | 2021-09-06 | 11:00 | Cobresal | 4–1 | Ñublense | Estadio El Cobre | José Cabero | Match Report | ||
| 20 | Mon | 2021-09-06 | 20:00 | U de Chile | 1–1 | La Serena | Estadio CODELCO-El Teniente | Cesar Deischler | Match Report | ||
| 20 | Tue | 2021-09-07 | 15:00 | Deportes Melipilla | 0–3 | Unión Española | Estadio Municipal de La Pintana | Matías Quila | Match Report | ||
| 20 | Tue | 2021-09-07 | 17:30 | Antofagasta | 1–1 | Curico Unido | Estadio Regional Calvo y Bascuñán | Rodrigo Carvajal | Match Report | ||
| 20 | Tue | 2021-09-07 | 20:00 | Univ Católica | 3–1 | Audax Italiano | Estadio San Carlos de Apoquindo | Francisco Gilabert | Match Report | ||
| 20 | Wed | 2021-09-08 | 15:30 | La Calera | 0–1 | Wanderers | 1,246 | Estadio Municipal Nicolás Chahuán Nazar | Gustavo Ahumada | Match Report | |
| 20 | Wed | 2021-09-08 | 18:00 | O'Higgins | 2–3 | Colo-Colo | Estadio CODELCO-El Teniente | Cristián Droguett | Match Report | ||
| 20 | Wed | 2021-09-08 | 20:30 | Everton | 1–0 | Palestino | Estadio Sausalito | Julio Bascuñán | Match Report | ||
| 21 | Sun | 2021-09-12 | 15:00 | Wanderers | 2–1 | Cobresal | 3,053 | Estadio Elías Figueroa Brander | Angelo Hermosilla | Match Report | |
| 21 | Sun | 2021-09-12 | 17:30 | Audax Italiano | 2–3 | La Calera | Estadio CODELCO-El Teniente | Cristián Garay | Match Report | ||
| 21 | Sun | 2021-09-12 | 20:00 | Curico Unido | 2–4 | Univ Católica | Estadio Bicentenario La Granja | Julio Bascuñán | Match Report | ||
| 21 | Mon | 2021-09-13 | 16:30 | Ñublense | 2–2 | Huachipato | 2,337 | Estadio Bicentenario Municipal Nelson Oy... | Eduardo Gamboa Latourniere | Match Report | |
| 21 | Mon | 2021-09-13 | 19:00 | Unión Española | 2–3 | U de Chile | 2,269 | Estadio Santa Laura-Universidad SEK | Manuel Vergara | Match Report | |
| 21 | Tue | 2021-09-14 | 14:00 | La Serena | 2–0 | O'Higgins | Estadio La Portada | Fernando Vejar | Match Report | ||
| 21 | Tue | 2021-09-14 | 19:00 | Colo-Colo | 2–0 | Everton | 9,390 | Estadio Monumental David Arellano | Benjamín Saravia | Match Report | |
| 21 | Wed | 2021-09-15 | 16:00 | Palestino | 3–1 | Deportes Melipilla | Estadio Municipal de La Cisterna | Héctor Jona | Match Report | ||
| 18 | Fri | 2021-09-17 | 11:00 | Cobresal | 1–1 | Huachipato | Estadio El Cobre | Felipe González | Match Report | ||
| 22 | Fri | 2021-09-24 | 18:30 | Huachipato | 1–1 | Palestino | 1,994 | Estadio CAP | Benjamín Saravia | Match Report | |
| 22 | Sat | 2021-09-25 | 12:00 | Cobresal | 2–0 | Antofagasta | 417 | Estadio El Cobre | Cristián Garay | Match Report | |
| 22 | Sat | 2021-09-25 | 15:00 | Unión Española | 2–1 | La Serena | 2,194 | Estadio Santa Laura-Universidad SEK | Cristián Droguett | Match Report | |
| 22 | Sat | 2021-09-25 | 17:30 | Deportes Melipilla | 1–1 | Audax Italiano | 243 | Estadio Municipal de La Pintana | Gustavo Ahumada | Match Report | |
| 22 | Sat | 2021-09-25 | 20:00 | Everton | 0–0 | Curico Unido | Estadio Sausalito | Nicolás Gamboa | Match Report | ||
| 22 | Fri | 2021-09-24 | 21:00 | La Calera | 2–0 | O'Higgins | 1,912 | Estadio Municipal Nicolás Chahuán Nazar | Manuel Vergara | Match Report | |
| 22 | Sun | 2021-09-26 | 12:00 | Ñublense | 1–2 | Wanderers | Estadio Bicentenario Municipal Nelson Oy... | José Cabero | Match Report | ||
| 22 | Sun | 2021-09-26 | 16:30 | U de Chile | 1–3 | Colo-Colo | 2,035 | Estadio CODELCO-El Teniente | Roberto Tobar | Match Report | |
| 23 | Tue | 2021-09-28 | 16:00 | La Serena | 0–2 | Everton | Estadio La Portada | Francisco Gilabert | Match Report | ||
| 23 | Wed | 2021-09-29 | 16:00 | Wanderers | 2–1 | U de Chile | 4,326 | Estadio Elías Figueroa Brander | Felipe González Alveal | Match Report | |
| 23 | Wed | 2021-09-29 | 18:30 | Antofagasta | 1–3 | La Calera | 1,759 | Estadio Regional Calvo y Bascuñán | Héctor Jona | Match Report | |
| 23 | Tue | 2021-09-28 | 21:00 | O'Higgins | 2–0 | Huachipato | 1,989 | Estadio CODELCO-El Teniente | José Cabero | Match Report | |
| 23 | Thu | 2021-09-30 | 16:00 | Curico Unido | 1–0 | Cobresal | Estadio Bicentenario La Granja | Benjamín Saravia | Match Report | ||
| 23 | Thu | 2021-09-30 | 18:30 | Colo-Colo | 0–1 | Ñublense | 9,949 | Estadio Monumental David Arellano | Christian Rojas | Match Report | |
| 23 | Wed | 2021-09-29 | 21:00 | Univ Católica | 4–0 | Deportes Melipilla | 3,360 | Estadio San Carlos de Apoquindo | Fernando Vejar | Match Report | |
| 23 | Thu | 2021-09-30 | 21:00 | Audax Italiano | 2–0 | Unión Española | 312 | Estadio CODELCO-El Teniente | Rodrigo Carvajal | Match Report | |
| 24 | Sat | 2021-10-02 | 20:30 | La Calera | 0–2 | Univ Católica | 1,427 | Estadio Municipal Nicolás Chahuán Nazar | Roberto Tobar | Match Report | |
| 24 | Sun | 2021-10-03 | 15:30 | Palestino | 1–2 | Colo-Colo | Estadio Municipal de La Cisterna | José Cabero | Match Report | ||
| 24 | Sun | 2021-10-03 | 18:00 | U de Chile | 2–2 | Antofagasta | 2,286 | Estadio CODELCO-El Teniente | Piero Maza | Match Report | |
| 24 | Sun | 2021-10-03 | 20:30 | Unión Española | 3–2 | O'Higgins | 2,182 | Estadio Santa Laura-Universidad SEK | Cesar Deischler | Match Report | |
| 24 | Mon | 2021-10-04 | 11:00 | Cobresal | 1–2 | Audax Italiano | 312 | Estadio El Cobre | Felipe González Alveal | Match Report | |
| 24 | Mon | 2021-10-04 | 18:30 | Deportes Melipilla | 1–1 | Wanderers | 486 | Estadio Municipal de La Pintana | Cristián Garay | Match Report | |
| 24 | Tue | 2021-10-05 | 20:30 | Ñublense | 0–1 | La Serena | Estadio Bicentenario Municipal Nelson Oy... | Julio Bascuñán | Match Report | ||
| 24 | Mon | 2021-10-04 | 21:00 | Huachipato | 1–4 | Curico Unido | 1,876 | Estadio CAP | Nicolás Gamboa | Match Report | |
| 25 | Wed | 2021-10-06 | 20:30 | Univ Católica | 2–1 | Unión Española | 8,663 | Estadio San Carlos de Apoquindo | Angelo Hermosilla | Match Report | |
| 25 | Sat | 2021-10-09 | 12:30 | Audax Italiano | 2–3 | Palestino | 722 | Estadio CODELCO-El Teniente | Manuel Vergara | Match Report | |
| 25 | Sat | 2021-10-09 | 15:30 | Everton | 1–0 | U de Chile | Estadio Sausalito | José Cabero | Match Report | ||
| 25 | Sat | 2021-10-09 | 18:00 | Antofagasta | 1–0 | Deportes Melipilla | 1,800 | Estadio Regional Calvo y Bascuñán | Rodrigo Carvajal | Match Report | |
| 25 | Sat | 2021-10-09 | 20:30 | Colo-Colo | 2–0 | Huachipato | Estadio Monumental David Arellano | Felipe González Alveal | Match Report | ||
| 25 | Sun | 2021-10-10 | 14:00 | La Serena | 2–1 | Cobresal | Estadio La Portada | Fernando Vejar | Match Report | ||
| 25 | Mon | 2021-10-11 | 16:00 | O'Higgins | 1–0 | Wanderers | 3,750 | Estadio CODELCO-El Teniente | Francisco Gilabert | Match Report | |
| 25 | Mon | 2021-10-11 | 20:30 | Curico Unido | 0–0 | Ñublense | Estadio Bicentenario La Granja | Héctor Jona | Match Report | ||
| 26 | Fri | 2021-10-15 | 12:30 | Huachipato | 0–1 | Antofagasta | 1,847 | Estadio CAP | José Cabero | Match Report | |
| 26 | Fri | 2021-10-15 | 16:00 | Palestino | 2–2 | O'Higgins | 786 | Estadio Municipal de La Cisterna | Nicolás Gamboa | Match Report | |
| 26 | Fri | 2021-10-15 | 18:30 | U de Chile | 0–1 | Audax Italiano | 3,126 | Estadio CODELCO-El Teniente | Felipe González Alveal | Match Report | |
| 26 | Sat | 2021-10-16 | 11:00 | Cobresal | 1–3 | Univ Católica | Estadio El Cobre | Cristián Garay | Match Report | ||
| 26 | Sat | 2021-10-16 | 15:00 | Wanderers | 2–1 | Everton | 7,332 | Estadio Elías Figueroa Brander | Julio Bascuñán | Match Report | |
| 26 | Sat | 2021-10-16 | 17:30 | Unión Española | 2–1 | Curico Unido | 2,915 | Estadio Santa Laura-Universidad SEK | Roberto Tobar | Match Report | |
| 26 | Sat | 2021-10-16 | 20:00 | Deportes Melipilla | 1–1 | La Serena | 583 | Estadio Municipal de La Pintana | Piero Maza | Match Report | |
| 26 | Fri | 2021-10-15 | 21:00 | Ñublense | 0–2 | La Calera | 2,653 | Estadio Bicentenario Municipal Nelson Oy... | Juan Lara | Match Report | |
| 27 | Tue | 2021-10-19 | 18:30 | Audax Italiano | 0–3 | Ñublense | 843 | Estadio CODELCO-El Teniente | Benjamín Saravia | Match Report | |
| 27 | Wed | 2021-10-20 | 14:00 | La Serena | 1–4 | Colo-Colo | 6,000 | Estadio La Portada | Manuel Vergara | Match Report | |
| 27 | Wed | 2021-10-20 | 18:30 | Univ Católica | 3–2 | Wanderers | 9,454 | Estadio San Carlos de Apoquindo | Roberto Tobar | Match Report | |
| 27 | Tue | 2021-10-19 | 21:00 | O'Higgins | 1–2 | Deportes Melipilla | 4,016 | Estadio CODELCO-El Teniente | Julio Bascuñán | Match Report | |
| 27 | Thu | 2021-10-21 | 16:00 | Antofagasta | 1–2 | Unión Española | 1,500 | Estadio Regional Calvo y Bascuñán | Nicolás Gamboa | Match Report | |
| 27 | Thu | 2021-10-21 | 18:30 | U de Chile | 0–1 | Palestino | 3,083 | Estadio CODELCO-El Teniente | Matías Quila | Match Report | |
| 27 | Wed | 2021-10-20 | 21:00 | Everton | 1–0 | Huachipato | 3,000 | Estadio Sausalito | Héctor Jona | Match Report | |
| 27 | Thu | 2021-10-21 | 21:00 | La Calera | 1–2 | Cobresal | Estadio Municipal Nicolás Chahuán Nazar | José Cabero | Match Report | ||
| 28 | Sat | 2021-10-23 | 18:00 | Ñublense | 1–1 | Everton | 2,710 | Estadio Bicentenario Municipal Nelson Oy... | Cristián Droguett | Match Report | |
| 28 | Sun | 2021-10-24 | 12:00 | Deportes Melipilla | 3–0 | U de Chile | 3,728 | Estadio Municipal de La Pintana | Benjamín Saravia | Match Report | |
| 28 | Sun | 2021-10-24 | 16:30 | Colo-Colo | 2–1 | Univ Católica | 27,090 | Estadio Monumental David Arellano | Julio Bascuñán | Match Report | |
| 28 | Sun | 2021-10-24 | 20:00 | Huachipato | 0–0 | Audax Italiano | 2,547 | Estadio CAP | Francisco Gilabert | Match Report | |
| 28 | Mon | 2021-10-25 | 12:30 | Wanderers | 0–1 | Antofagasta | 3,070 | Estadio Elías Figueroa Brander | Angelo Hermosilla | Match Report | |
| 28 | Mon | 2021-10-25 | 16:00 | Palestino | 3–3 | La Serena | Estadio Municipal de La Cisterna | Gustavo Ahumada | Match Report | ||
| 28 | Tue | 2021-10-26 | 11:00 | Cobresal | 2–3 | O'Higgins | 323 | Estadio El Cobre | Rodrigo Carvajal | Match Report | |
| 28 | Mon | 2021-10-25 | 21:00 | Curico Unido | 1–1 | La Calera | 4,500 | Estadio Bicentenario La Granja | Héctor Jona | Match Report | |
| 29 | Thu | 2021-10-28 | 18:00 | Audax Italiano | 2–0 | Colo-Colo | 352 | Estadio CODELCO-El Teniente | Cristián Garay | Match Report | |
| 29 | Fri | 2021-10-29 | 15:30 | Wanderers | 1–1 | Palestino | 4,057 | Estadio Elías Figueroa Brander | José Cabero | Match Report | |
| 29 | Fri | 2021-10-29 | 17:50 | La Serena | 2–2 | Huachipato | 2,996 | Estadio La Portada | Felipe González Alveal | Match Report | |
| 29 | Sat | 2021-10-30 | 16:00 | U de Chile | 1–2 | Curico Unido | 4,477 | Estadio CODELCO-El Teniente | Francisco Gilabert | Match Report | |
| 29 | Sat | 2021-10-30 | 18:30 | Unión Española | 3–2 | Everton | 2,698 | Estadio Santa Laura-Universidad SEK | Roberto Tobar | Match Report | |
| 29 | Sun | 2021-10-31 | 12:30 | Antofagasta | 2–1 | Ñublense | 1,500 | Estadio Regional Calvo y Bascuñán | Manuel Vergara | Match Report | |
| 29 | Sun | 2021-10-31 | 18:00 | O'Higgins | 1–3 | Univ Católica | 5,370 | Estadio CODELCO-El Teniente | Fernando Vejar | Match Report | |
| 29 | Sun | 2021-10-31 | 20:30 | La Calera | 2–3 | Deportes Melipilla | 1,921 | Estadio Municipal Nicolás Chahuán Nazar | Julio Bascuñán | Match Report | |
| 30 | Wed | 2021-11-03 | 16:00 | Deportes Melipilla | 2–1 | Cobresal | 450 | Estadio Municipal de La Pintana | Gustavo Ahumada | Match Report | |
| 30 | Wed | 2021-11-03 | 18:30 | Huachipato | 1–0 | Unión Española | 2,727 | Estadio CAP | Francisco Gilabert | Match Report | |
| 30 | Tue | 2021-11-02 | 21:00 | Everton | 1–2 | Audax Italiano | 3,000 | Estadio Sausalito | Angelo Hermosilla | Match Report | |
| 30 | Thu | 2021-11-04 | 15:30 | Palestino | 1–2 | La Calera | 400 | Estadio Municipal de La Cisterna | Cristián Droguett | Match Report | |
| 30 | Thu | 2021-11-04 | 18:00 | Univ Católica | 4–0 | Antofagasta | 7,931 | Estadio San Carlos de Apoquindo | Cristián Garay | Match Report | |
| 30 | Thu | 2021-11-04 | 20:30 | Ñublense | 1–0 | U de Chile | 6,295 | Estadio Bicentenario Municipal Nelson Oy... | Héctor Jona | Match Report | |
| 30 | Wed | 2021-11-03 | 21:00 | Curico Unido | 0–2 | O'Higgins | 4,000 | Estadio Bicentenario La Granja | Roberto Tobar | Match Report | |
| 30 | Sat | 2021-11-06 | 18:00 | Colo-Colo | 3–0 | Wanderers | 21,264 | Estadio Monumental David Arellano | Felipe González Alveal | Match Report | |
| 31 | Sun | 2021-11-07 | 12:00 | Univ Católica | 1–0 | U de Chile | 8,506 | Estadio San Carlos de Apoquindo | Julio Bascuñán | Match Report | |
| 31 | Sun | 2021-11-07 | 16:00 | O'Higgins | 1–1 | Ñublense | 3,938 | Estadio CODELCO-El Teniente | Piero Maza | Match Report | |
| 31 | Sun | 2021-11-07 | 18:30 | Cobresal | 2–2 | Everton | 687 | Estadio El Cobre | José Cabero | Match Report | |
| 31 | Mon | 2021-11-08 | 18:00 | Antofagasta | 0–0 | La Serena | 1,800 | Estadio Regional Calvo y Bascuñán | Matías Quila | Match Report | |
| 31 | Mon | 2021-11-08 | 20:30 | Unión Española | 1–3 | Palestino | Estadio Santa Laura-Universidad SEK | Rodrigo Carvajal | Match Report | ||
| 31 | Sun | 2021-11-07 | 21:00 | La Calera | 0–2 | Huachipato | 1,681 | Estadio Municipal Nicolás Chahuán Nazar | Manuel Vergara | Match Report | |
| 31 | Tue | 2021-11-09 | 19:00 | Wanderers | 0–3 | Curico Unido | 5,399 | Estadio Elías Figueroa Brander | Benjamín Saravia | Match Report | |
| 31 | Wed | 2021-11-10 | 19:00 | Colo-Colo | 1–0 | Deportes Melipilla | Estadio Monumental David Arellano | Angelo Hermosilla | Match Report | ||
| 32 | Sat | 2021-11-13 | 12:30 | Ñublense | 6–1 | Unión Española | 3,820 | Estadio Bicentenario Municipal Nelson Oy... | Felipe González Alveal | Match Report | |
| 32 | Sat | 2021-11-13 | 15:30 | La Serena | 0–2 | Univ Católica | Estadio La Portada | José Cabero | Match Report | ||
| 32 | Sun | 2021-11-14 | 12:30 | Audax Italiano | 0–0 | Antofagasta | 470 | Estadio CODELCO-El Teniente | Fernando Vejar | Match Report | |
| 32 | Sun | 2021-11-14 | 16:00 | Palestino | 2–1 | Cobresal | 300 | Estadio Municipal de La Cisterna | Juan Lara | Match Report | |
| 32 | Sun | 2021-11-14 | 18:30 | Curico Unido | 0–0 | Colo-Colo | 4,330 | Estadio Bicentenario La Granja | Roberto Tobar | Match Report | |
| 32 | Sat | 2021-11-13 | 21:00 | Everton | 1–2 | La Calera | Estadio Sausalito | Francisco Gilabert | Match Report | ||
| 32 | Mon | 2021-11-15 | 17:30 | Huachipato | 2–0 | Wanderers | 3,206 | Estadio CAP | Julio Bascuñán | Match Report | |
| 32 | Mon | 2021-11-15 | 20:00 | U de Chile | 0–0 | O'Higgins | Estadio CODELCO-El Teniente | Benjamín Saravia | Match Report | ||
| 33 | Sat | 2021-11-27 | 18:00 | Cobresal | 0–0 | U de Chile | Estadio El Cobre | Cristián Garay | Match Report | ||
| 33 | Sat | 2021-11-27 | 18:00 | Deportes Melipilla | 1–0 | Everton | 2,398 | Estadio Municipal de La Pintana | Juan Lara | Match Report | |
| 33 | Sat | 2021-11-27 | 18:00 | O'Higgins | 0–0 | Antofagasta | Estadio CODELCO-El Teniente | Francisco Gilabert | Match Report | ||
| 33 | Sun | 2021-11-28 | 12:00 | Wanderers | 2–2 | Audax Italiano | Estadio Elías Figueroa Brander | Angelo Hermosilla | Match Report | ||
| 33 | Sun | 2021-11-28 | 18:00 | Colo-Colo | 0–1 | Unión Española | Estadio Monumental David Arellano | Piero Maza | Match Report | ||
| 33 | Sun | 2021-11-28 | 18:00 | Univ Católica | 2–0 | Huachipato | 8,348 | Estadio San Carlos de Apoquindo | Felipe González Alveal | Match Report | |
| 33 | Sun | 2021-11-28 | 18:00 | Curico Unido | 1–1 | Palestino | Estadio Bicentenario La Granja | José Cabero | Match Report | ||
| 33 | Sun | 2021-11-28 | 18:00 | La Calera | 1–2 | La Serena | 2,683 | Estadio Municipal Nicolás Chahuán Nazar | Fernando Vejar | Match Report | |
| 34 | Sat | 2021-12-04 | 18:00 | Antofagasta | 1–0 | Colo-Colo | Estadio Regional Calvo y Bascuñán | Felipe González Alveal | Match Report | ||
| 34 | Sat | 2021-12-04 | 18:00 | Everton | 0–3 | Univ Católica | Estadio Sausalito | Julio Bascuñán | Match Report | ||
| 34 | Sat | 2021-12-04 | 18:00 | Palestino | 1–4 | Ñublense | Estadio Municipal de La Cisterna | Cristián Garay | Match Report | ||
| 34 | Sat | 2021-12-04 | 18:00 | La Serena | 0–0 | Wanderers | 3,962 | Estadio La Portada | María Carvajal | Match Report | |
| 34 | Sun | 2021-12-05 | 18:00 | U de Chile | 3–2 | La Calera | Estadio CODELCO-El Teniente | Benjamín Saravia | Match Report | ||
| 34 | Sun | 2021-12-05 | 18:00 | Unión Española | 0–1 | Cobresal | Estadio Santa Laura-Universidad SEK | Fernando Vejar | Match Report | ||
| 34 | Sun | 2021-12-05 | 18:00 | Huachipato | 3–1 | Deportes Melipilla | Estadio CAP | Francisco Gilabert | Match Report | ||
| 34 | Sun | 2021-12-05 | 18:00 | Audax Italiano | 1–1 | Curico Unido | Estadio CODELCO-El Teniente | Juan Lara | Match Report |
| Day | Date | Time | Home | Score | Away | Attendance | Venue | Referee | Match Report | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
| Sat | 2022-01-22 | 18:00 | Deportes Copiapó | 2–3 | Huachipato | Estadio Luis Valenzuela Hermosilla | Felipe González Alveal | Match Report | Leg 1 of 2 | |
| Wed | 2022-01-26 | 19:00 | Huachipato | 1–0 | Deportes Copiapó | Estadio CAP | Francisco Gilabert | Match Report | Leg 2 of 2; Huachipato won |
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